1. Rhabdomyosarcoma targeting with tuned porous silicon nanoparticles
- Author
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Sofia Dominguez‐Gil, Rita Sala, Victoria Judith Morel, Christophe Nguyen, Khaled El Cheikh, Alain Morère, Jean‐Olivier Durand, Jochen Rössler, Michele Bernasconi, Frédérique Cunin, and Magali Gary‐Bobo
- Subjects
mannose 6‐phosphate receptor ,porous silicon nanoparticles ,Rhabdomyosarcoma targeting ,two‐photon excitation photodynamic therapy ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Abstract We describe porous silicon nanoparticles (pSiNP) chemically functionalized with an analog of mannose 6‐phosphate (AMFA) and a porphyrin derivative to target aggressive pediatric Rhabdomyosarcoma (RMS) tumor cells. Our findings demonstrate that the pSiNP@AMFA@porphyrin nanosystems are efficiently internalized by RMS cells, which overexpress mannose 6‐phosphate receptors, and induce cytotoxicity and phototoxicity when exposed to two‐photon excitation light. These results provide an interesting potential for targeting and treating RMS pediatric tumors.
- Published
- 2024
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