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7 results on '"Chu, Qingxia"'

4. Drug loading strategy of modular self‐assembly mode: Curcumin pyrimidine derivatives mediated by pH‐sensitive materials

Author

Feng, Jiankang, primary, Wang, Shuo, additional, Liu, Ying, additional, Zhou, Meng, additional, Chai, Tiantian, additional, Zhang, Mengtong, additional, Hu, Jingnan, additional, Feng, Xibing, additional, Chu, Qingxia, additional, Shao, Shihe, additional, Shi, Junhua, additional, Lu, Chichong, additional, and Jin, Guofan, additional

Published
2024
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5. Based on Eudragit® encapsulated ionic polymer IR775@nido-carborane strategy: release, bioactivity and tumor cell imaging studies in simulated gastrointestinal environment.

Author

Wang, Shuo, Liu, Ying, Zhou, Meng, Feng, Jiankang, Chai, Tiantian, Hu, Jingnan, Chu, Qingxia, Shao, Shihe, Lu, Chichong, and Jin, Guofan

Abstract

To enhance the bioavailability of carborane as a potential pharmacophore for BNCT, we labeled the modified o-carborane with the near-infrared dye IR775 and encapsulated it using two types of Eudragit® (pH-sensitive and osmotic). Consequently, four separate fluorescent complexes containing carborane were acquired. To confirm the nido-carborane presence within these complexes, the distinct peak at 2510 cm−1 was detected using infrared spectroscopy as a first step. The photophysical properties were observed in phosphate buffer with different pH. The UV and fluorescence spectra of the four fluorescent complexes were very similar, with the maximum absorption wavelengths centered in the range of 773–789 nm and the emission wavelengths centered in the range of 796–811 nm. Subsequently, a stable and releasing complex L100-C-IR775 was screened through zeta potential testing and simulated release experiments in the gastrointestinal environment, and spherical shape was observed by transmission electron microscopy. AFM imaging showed a relatively smooth surface with a uniform distribution of protrusions. The L100-C-IR775 was then applied to tumor cell imaging, and it was observed that it could enter into three kinds of tumor cells, A549, HCT116 and HeLa, and distribute around the nucleus. Finally, it was shown by a cell proliferation toxicity assay (CCK8) that the compound inhibited HeLa and PC-3 cells by 50 and 51% at concentrations up to 10 µg/mL. In conclusion, the carborane fluorescent complexes prepared in this paper have good biocompatibility and demonstrate toxicity toward tumor cell proliferation. Furthermore, they have the potential to serve as a carbon borane anti-tumor prodrug. An acrylic encapsulated ionic polymer IR775@nido-carborane simulates release in the gastrointestinal environment, tumor cells imaging, and schematics of therapeutic mechanisms. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Long Noncoding RNA HEIH Promotes Proliferation, Migration and Invasion of Retinoblastoma Cells Through miR-194-5p/WEE1 Axis

Author

Gao,Sheng, Chu,Qingxia, Liu,Xia, Zhao,Xia, Qin,Libao, Li,Guoliang, and Liu,Qinghuai

Subjects
OncoTargets and Therapy
Abstract

Sheng Gao,1 Qingxia Chu,1 Xia Liu,1 Xia Zhao,2 Libao Qin,1 Guoliang Li,1 Qinghuai Liu3 1Department of Ophthalmology, Nanjing Pukou Central Hospital, Nanjing 211800, People’s Republic of China; 2Department of Ophthalmology, Tangshan Eye Hospital, Tangshan 063000, People’s Republic of China; 3Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of ChinaCorrespondence: Qinghuai LiuDepartment of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, 300# Guangzhou Road, Gulou District, Nanjing 210029, People’s Republic of ChinaEmail liuqinghuai6304@hotmail.comBackground: Abnormally expressed long noncoding RNA (lncRNA) high expression in hepatocellular carcinoma (HEIH) has been implicated in many types of human cancer, and plays crucial roles in tumor development and progression. However, little is known about its function in retinoblastoma.Methods: qRT-PCR was used to determine the expression levels of HEIH, miR-194-5p and WEE1 in retinoblastoma tissues and cell lines. The trypan blue exclusion method, colony formation assay, wound-healing assay and transwell invasion assay were performed to evaluate the effects of HEIH, miR-194-5p and WEE1 on cell proliferation, migration and invasion. Bioinformatics analysis, dual-luciferase reporter assay and Western blot were employed to investigate the regulatory relationship among HEIH, miR-194-5p and WEE1.Results: We found that HEIH was up-regulated in retinoblastoma tissues and cell lines. Furthermore, high level of HEIH was associated with TNM stage, optic nerve invasion and choroidal invasion of patients with retinoblastoma. Functional studies showed that HEIH knockdown significantly suppressed retinoblastoma cell proliferation, migration and invasion. Mechanistically, HEIH promoted retinoblastoma progression by serving as a sponge of miR-194-5p to regulate WEE1 expression.Conclusion: Our work suggests that HEIH acts as an oncogenic lncRNA to promote retinoblastoma proliferation and metastasis, providing a new insight into the retinoblastoma treatment.Keywords: retinoblastoma, HEIH, miR-194-5p, WEE1, metastasis

Published
2020

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