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Your search keyword '"Chua, Yong Wei"' showing total 11 results
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11 results on '"Chua, Yong Wei"'

1. Pro-metastatic and mesenchymal gene expression signatures characterize circulating tumor cells of neuroblastoma patients with bone marrow metastases and relapse

Author

Loh, Amos H. P., primary, Angelina, Clara, additional, Wong, Meng Kang, additional, Tan, Sheng Hui, additional, Sukhatme, Sarvesh A., additional, Yeo, Trifanny, additional, Lim, Su Bin, additional, Lee, York Tien, additional, Soh, Shui Yen, additional, Leung, Wing, additional, Chang, Kenneth T. E., additional, Chua, Yong Wei, additional, Alkaff, Syed M. F., additional, Lim, Tony K. H., additional, Lim, Chwee Teck, additional, and Chen, Zhi Xiong, additional

Published
2022
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3. Complementary Sequential Circulating Tumor Cell (CTC) and Cell-Free Tumor DNA (ctDNA) Profiling Reveals Metastatic Heterogeneity and Genomic Changes in Lung Cancer and Breast Cancer

Author

Kong, Say Li, primary, Liu, Xingliang, additional, Tan, Swee Jin, additional, Tai, Joyce A., additional, Phua, Ler Yee, additional, Poh, Huay Mei, additional, Yeo, Trifanny, additional, Chua, Yong Wei, additional, Haw, Yu Xuan, additional, Ling, Wen Huan, additional, Ng, Raymond Chee Hui, additional, Tan, Tira J., additional, Loh, Kiley Wei Jen, additional, Tan, Daniel Shao-Weng, additional, Ng, Quan Sing, additional, Ang, Mei Kim, additional, Toh, Chee Keong, additional, Lee, Yi Fang, additional, Lim, Chwee Teck, additional, Lim, Tony Kiat Hon, additional, Hillmer, Axel M., additional, Yap, Yoon Sim, additional, and Lim, Wan-Teck, additional

Published
2021
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4. Complementary Sequential Circulating Tumor Cell (CTC) and Cell-Free Tumor DNA (ctDNA) Profiling Reveals Metastatic Heterogeneity and Genomic Changes in Lung Cancer and Breast Cancer

Author

Kong, Say Li, Liu, Xingliang, Tan, Swee Jin, Tai, Joyce A., Phua, Ler Yee, Poh, Huay Mei, Yeo, Trifanny, Chua, Yong Wei, Haw, Yu Xuan, Ling, Wen Huan, Ng, Raymond Chee Hui, Tan, Tira J., Loh, Kiley Wei Jen, Tan, Daniel Shao-Weng, Ng, Quan Sing, Ang, Mei Kim, Toh, Chee Keong, Lee, Yi Fang, Lim, Chwee Teck, Lim, Tony Kiat Hon, Hillmer, Axel M., Yap, Yoon Sim, Lim, Wan-Teck, Kong, Say Li, Liu, Xingliang, Tan, Swee Jin, Tai, Joyce A., Phua, Ler Yee, Poh, Huay Mei, Yeo, Trifanny, Chua, Yong Wei, Haw, Yu Xuan, Ling, Wen Huan, Ng, Raymond Chee Hui, Tan, Tira J., Loh, Kiley Wei Jen, Tan, Daniel Shao-Weng, Ng, Quan Sing, Ang, Mei Kim, Toh, Chee Keong, Lee, Yi Fang, Lim, Chwee Teck, Lim, Tony Kiat Hon, Hillmer, Axel M., Yap, Yoon Sim, and Lim, Wan-Teck

Abstract

Introduction Circulating tumor cells (CTCs) and cell-free tumor DNA (ctDNA) are tumor components present in circulation. Due to the limited access to both CTC enrichment platforms and ctDNA sequencing in most laboratories, they are rarely analyzed together. Methods Concurrent isolation of ctDNA and single CTCs were isolated from lung cancer and breast cancer patients using the combination of size-based and CD45-negative selection method via DropCell platform. We performed targeted amplicon sequencing to evaluate the genomic heterogeneity of CTCs and ctDNA in lung cancer and breast cancer patients. Results Higher degrees of genomic heterogeneity were observed in CTCs as compared to ctDNA. Several shared alterations present in CTCs and ctDNA were undetected in the primary tumor, highlighting the intra-tumoral heterogeneity of tumor components that were shed into systemic circulation. Accordingly, CTCs and ctDNA displayed higher degree of concordance with the metastatic tumor than the primary tumor. The alterations detected in circulation correlated with worse survival outcome for both lung and breast cancer patients emphasizing the impact of the metastatic phenotype. Notably, evolving genetic signatures were detected in the CTCs and ctDNA samples during the course of treatment and disease progression. Conclusions A standardized sample processing and data analysis workflow for concurrent analysis of CTCs and ctDNA successfully dissected the heterogeneity of metastatic tumor in circulation as well as the progressive genomic changes that may potentially guide the selection of appropriate therapy against evolving tumor clonality.

Published
2021

5. Neuroblastoma patient‐derived cultures are enriched for a mesenchymal gene signature and reflect individual drug response

Author

Hee, Esther, primary, Wong, Meng Kang, additional, Tan, Sheng Hui, additional, Choo, Zhang’E, additional, Kuick, Chik Hong, additional, Ling, Sharon, additional, Yong, Min Hwee, additional, Jain, Sudhanshi, additional, Lian, Derrick W. Q., additional, Ng, Eileen H. Q., additional, Yong, Yvonne F. L., additional, Ren, Mee Hiong, additional, Syed Sulaiman, Nurfarhanah, additional, Low, Sharon Y. Y., additional, Chua, Yong Wei, additional, Syed, Muhammad Fahmy, additional, Lim, Tony K. H., additional, Soh, Shui Yen, additional, Iyer, Prasad, additional, Seng, Michaela S. F., additional, Lam, Joyce C. M., additional, Tan, Enrica E. K., additional, Chan, Mei Yoke, additional, Tan, Ah Moy, additional, Chen, Yong, additional, Chen, Zhixiong, additional, Chang, Kenneth T. E., additional, and Loh, Amos Hong Pheng, additional

Published
2020
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6. Detection and prognostic relevance of circulating tumour cells (CTCs) in Asian breast cancers using a label-free microfluidic platform

Author

Yap, Yoon-Sim, primary, Leong, Man Chun, additional, Chua, Yong Wei, additional, Loh, Kiley Wei Jen, additional, Lee, Guek Eng, additional, Lim, Elaine Hsuen, additional, Dent, Rebecca, additional, Ng, Raymond Chee Hui, additional, Lim, John Heng-Chi, additional, Singh, Garima, additional, Tan, Angela, additional, Guan, Guofeng, additional, Wu, Andrew, additional, Lee, Yi Fang, additional, Bhagat, Ali Asgar S., additional, and Lim, Darren Wan-Teck, additional

Published
2019
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8. Abstract 5008: Elucidating HER2 molecular heterogeneity of circulating tumor cells among breast cancer patients

Author

Leong, Man Chun, primary, Lim, Tse Hui, additional, Tan, Chye Ling, additional, Chua, Yong Wei, additional, Lim, Elaine Hsuen, additional, Loh, Kiley Wei Jen, additional, Lee, Guek Eng, additional, Dent, Rebecca, additional, Ng, Raymond Chee Hui, additional, Wu, Andrew, additional, Lim, Wan-Teck, additional, Lim, Alvin Soon-Tiong, additional, and Yap, Yoon-Sim, additional

Published
2016
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10. Concordance of anaplastic lymphoma kinase (ALK) gene rearrangements between circulating tumor cells and tumor in non-small cell lung cancer

Author

Tan, Chye Ling, primary, Lim, Tse Hui, additional, Lim, Tony KH, additional, Tan, Daniel Shao-Weng, additional, Chua, Yong Wei, additional, Ang, Mei Kim, additional, Pang, Brendan, additional, Lim, Chwee Teck, additional, Takano, Angela, additional, Lim, Alvin Soon-Tiong, additional, Leong, Man Chun, additional, and Lim, Wan-Teck, additional

Published
2016
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