20 results on '"Chuanqi Peng"'
Search Results
2. Control of occlusion of middle cerebral artery in perinatal and neonatal mice with magnetic force
- Author
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Jie-Min Jia, Chuanqi Peng, Yihui Wang, Jie Zheng, and Woo-Ping Ge
- Subjects
Magnetic force ,Magnetic nanoparticles ,Ischemic perinatal stroke ,Ischemic neonatal stroke ,SIMPLE ,Distal MCA ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Ischemic perinatal stroke (IPS) is common, resulting in significant mortality and morbidity. In such cases, the incidence of unilateral arterial cerebral infarction is often occluded in the middle cerebral artery (MCA), leading to focal ischemia. In adult rodents, blockage of MCA is the most frequently used strategy for ischemic stroke study. However, modeling MCA occlusion (MCAo) in postnatal day 0–7 (P0–7) mouse pups for IPS study has not been accomplished. Here we occluded the dMCA by inducing the accumulation of magnetic particles (MPs) administered through the superficial temporal vein of mice between P0 and P7, which we called neonatal or perinatal SIMPLE (Stroke Induced with Magnetic Particles). SIMPLE produced either permanent or transient occlusion in the dMCA of perinatal and neonatal mice. Permanent MCA occlusion with SIMPLE resulted in cerebral infarction and neuronal death in the brain. SIMPLE can also be used to reliably produce focal ischemic stroke in neonatal or perinatal mouse brains. As a result, SIMPLE allows the modeling of IPS or focal ischemic stroke for further mechanistic studies in mice, with particular utility for mimicking transient focal ischemia in human pre-term babies, which for the first time here has been accomplished in mice.
- Published
- 2018
- Full Text
- View/download PDF
3. Biphenyl Wrinkled Mesoporous Silica Nanoparticles for pH-Responsive Doxorubicin Drug Delivery
- Author
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Jason Lin, Chuanqi Peng, Sanjana Ravi, A. K. M. Nur Alam Siddiki, Jie Zheng, and Kenneth J. Balkus
- Subjects
wrinkled mesoporous silica ,drug delivery ,pH selective ,doxorubicin ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
Biphenyl wrinkled mesoporous silica nanoparticles with controlled particle size and high surface area were evaluated for the storage and delivery of doxorubicin. The average particle size and surface area were ~70 nm and ~1100 m2/g. The doxorubicin loading efficiency was 38.2 ± 1.5 (w/w)% and the release was pH dependent. The breast cancer cell line, MCF-7 (Michigan Cancer Foundation-7) was used for the in vitro drug release study. The cytotoxicity of doxorubicin-loaded nanoparticles was significantly higher than free doxorubicin. Fluorescence images showed biphenyl wrinkled mesoporous silica (BPWS) uptake by the MCF-7 cells. The biphenyl bridged wrinkled silica nanoparticles appear promising for hydrophobic drug loading and delivery.
- Published
- 2020
- Full Text
- View/download PDF
4. Physiological stability and renal clearance of ultrasmall zwitterionic gold nanoparticles: Ligand length matters
- Author
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Xuhui Ning, Chuanqi Peng, Eric S. Li, Jing Xu, Rodrigo D. Vinluan III, Mengxiao Yu, and Jie Zheng
- Subjects
Biotechnology ,TP248.13-248.65 ,Physics ,QC1-999 - Abstract
Efficient renal clearance has been observed from ultrasmall zwitterionic glutathione-coated gold nanoparticles (GS-AuNPs), which have broad preclinical applications in cancer diagnosis and kidney functional imaging. However, origin of such efficient renal clearance is still not clear. Herein, we conducted head-to-head comparison on physiological stability and renal clearance of two zwitterionic luminescent AuNPs coated with cysteine and glycine-cysteine (Cys-AuNPs and Gly-Cys-AuNPs), respectively. While both of them exhibited similar surface charges and the same core sizes, additional glycine slightly increased the hydrodynamic diameter of the AuNPs by 0.4 nm but significantly enhanced physiological stability of the AuNPs as well as altered their clearance pathways. These studies indicate that the ligand length, in addition to surface charges and size, also plays a key role in the physiological stability and renal clearance of ultrasmall zwitterionic inorganic NPs.
- Published
- 2017
- Full Text
- View/download PDF
5. Renal clearable nanocarriers: Overcoming the physiological barriers for precise drug delivery and clearance
- Author
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Chuanqi Peng, Jie Zheng, and Yingyu Huang
- Subjects
medicine.medical_treatment ,Pharmaceutical Science ,Antineoplastic Agents ,02 engineering and technology ,Article ,03 medical and health sciences ,Drug Delivery Systems ,Genome editing ,Neoplasms ,Tumor Microenvironment ,Humans ,Medicine ,Macrophage ,030304 developmental biology ,Drug Carriers ,0303 health sciences ,Tumor microenvironment ,business.industry ,Cancer ,Immunotherapy ,021001 nanoscience & nanotechnology ,medicine.disease ,Nanomedicine ,Pharmaceutical Preparations ,Drug delivery ,Cancer research ,Nanoparticles ,Nanocarriers ,0210 nano-technology ,business - Abstract
Physiological barriers encountered in the clinical translation of cancer nanomedicines inspire the community to more deeply understand nano-bio interactions in not only tumor microenvironment but also entire body and develop new nanocarriers to tackle these barriers. Renal clearable nanocarriers are one kind of these newly emerged drug delivery systems (DDSs), which enable drugs to rapidly penetrate into the tumor cores with no need of long blood retention and escape macrophage uptake in the meantime they can also enhance body elimination of non-targeted anticancer drugs. As a result, they can improve therapeutic efficacies and reduce side effects of anticancer drugs. Not limited to anticancer drugs, diagnostic agents can also be achieved with these renal clearable DDSs, which might also be applied to improve the precision in the gene editing and immunotherapy in the future.
- Published
- 2020
6. In Situ Ligand-Directed Growth of Gold Nanoparticles in Biological Tissues
- Author
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Chuanqi Peng, Mengxiao Yu, and Jie Zheng
- Subjects
In situ ,Luminescence ,Brush border ,Metal Nanoparticles ,Nanoparticle ,Bioengineering ,02 engineering and technology ,Ligands ,Hippocampus ,Article ,chemistry.chemical_compound ,Tissue engineering ,Humans ,General Materials Science ,Sulfhydryl Compounds ,chemistry.chemical_classification ,Tissue Engineering ,Ligand ,Chemistry ,Mechanical Engineering ,General Chemistry ,Glutathione ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Mitochondria ,Glucose ,Kidney Tubules ,Colloidal gold ,Biophysics ,Thiol ,Gold ,0210 nano-technology - Abstract
Fundamental understandings and precise control of nanoparticle growth in the complex biological environment are crucial to broadening their potential applications in tissue imaging. Herein, we report that glutathione (GSH), a widely used capping ligand for precise control of the size of gold nanoparticle (AuNP) down to single-atom level in test tubes, can also be used to direct the selective growth of the AuNPs in the mitochondria of renal tubule cells as well as hippocampus cells in the tissues. Precise control of this growth process can lead to the formation of both ultrasmall AuNPs with near-infrared luminescence and large plasmonic AuNPs. The observed selective growth of the AuNPs is likely due to unique GSH storage function of the mitochondria. Using a different ligand, β-glucose thiol, we also found that the brush border of the intestine for glucose absorption became the major site for the growth of luminescent AuNPs. These findings suggest that selective growth of AuNPs in the biological tissues can indeed be directed with specific ligands, opening up a new avenue to tissue labeling and future development of artificial bionano hybrid systems.
- Published
- 2019
7. Correlating Anticancer Drug Delivery Efficiency with Vascular Permeability of Renal Clearable Versus Non‐renal Clearable Nanocarriers
- Author
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Jie Zheng, Mengxiao Yu, Chuanqi Peng, Jer Tsong Hsieh, and Payal Kapur
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010405 organic chemistry ,business.industry ,Cancer ,Vascular permeability ,General Chemistry ,010402 general chemistry ,medicine.disease ,01 natural sciences ,Anticancer drug ,Catalysis ,0104 chemical sciences ,Therapeutic index ,Colloidal gold ,Drug delivery ,Cancer research ,Medicine ,Doxorubicin ,Nanocarriers ,business ,medicine.drug - Abstract
Enhancing tumor targeting of nanocarriers has been a major strategy for advancing clinical translation of cancer nanomedicines. Herein, we report a head-to-head comparison between 5 nm renal clearable and 30 nm non-renal clearable gold nanoparticle (AuNP)-based drug delivery systems (DDSs) in the delivery of doxorubicin (DOX). While the two DDSs themselves had comparable tumor targeting, we found their different vascular permeability played an even more important role than blood retention in the delivery and intratumoral transport of DOX, of which tumor accumulation, efficacy, and therapeutic index were enhanced 2, 7, and 10-fold, respectively, for the 5 nm DDS over 30 nm one. These findings indicate that ultrahigh vascular permeability of renal clearable nanocarriers can be utilized to further improve anticancer drug delivery without the need for prolonged blood retention.
- Published
- 2019
8. Enhancing ZnO nanowire gas sensors using Au/Fe
- Author
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Bo, Zhang, Yingyu, Huang, Rodrigo, Vinluan, Sibo, Wang, Can, Cui, Xingxu, Lu, Chuanqi, Peng, Mingwan, Zhang, Jie, Zheng, and Pu-Xian, Gao
- Abstract
Heterojunctions are an important strategy for designing high performance electrical sensor materials and related devices. Herein, a new type of metal-semiconductor hybrid nanoparticle has been successfully used to remarkably sensitize the surface of ZnO nanowires for detecting NO
- Published
- 2020
9. On the issue of transparency and reproducibility in nanomedicine
- Author
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Peter Wick, Luis Santos, Stefan Wilhelm, Patrick Boisseau, Huiliang Cao, Wen Jiang, Anders Baun, Serguei Kozlov, Andrew Owen, Roger G. Harrison, Iseult Lynch, Christine Dufès, Nanna B. Hartmann, Adriele Prina-Mello, May Azzawi, Bujie Du, Paul S. Weiss, Mansoor M. Amiji, Lauge Peter Westergaard Clausen, Lang Tran, José Neves, Andre E. Nel, Priyabrata Mukherjee, Barbara Rothen-Rutishauser, Christopher J. Scott, Marlene Ågerstrand, Liangfang Zhang, Hélder A. Santos, Hon S. Leong, Mauro Ferrari, Rachael M. Crist, Sara Busatto, Mengxiao Yu, Steffen Foss Hansen, C. Jeffrey Brinker, Ronnie H. Fang, Korin E. Wheeler, Steve P. Rannard, Bengt Fadeel, Betty Y.S. Kim, Lacey R. McNally, Zhen Gu, Clare Hoskins, Steve Conlan, Chuanqi Peng, Steve Little, Aaron Lee, Scott E. McNeil, Joy Wolfram, Chuanbin Mao, Tian Xia, Dan Peer, Fanny Caputo, Jie Zheng, Alke Petri-Fink, Samir Mitragotri, Chunying Chen, Leaf Huang, Dimitrios A. Lamprou, Handan Acar, Lars Michael Skjolding, Xuanyong Liu, Sayed Moein Moghimi, Ruth Schmid, Gang Zheng, Rajagopal Ramesh, Wantong Song, Chiara Pastore, Bruno Sarmento, Kimberly S. Butler, Barbara Drasler, Danielle M. Charron, Marina A. Dobrovolskaia, Paolo Bergese, Sandor Balog, Andrew J. Chetwynd, Klaus D. Jandt, and María J. Alonso
- Subjects
Nanotechnology, Nanochemistry, Nanomedicine ,Computer science ,Biomedical Engineering ,Bioengineering ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Transparency (behavior) ,Atomic and Molecular Physics, and Optics ,Checklist ,Article ,0104 chemical sciences ,Nanomedicine ,Nanotechnology ,General Materials Science ,Engineering ethics ,Electrical and Electronic Engineering ,Nanochemistry ,0210 nano-technology - Abstract
Following our call to join in the discussion over the suitability of implementing a reporting checklist for bio–nano papers, the community responds.
- Published
- 2019
10. Tuning the In Vivo Transport of Anticancer Drugs Using Renal‐Clearable Gold Nanoparticles
- Author
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Chuanqi Peng, Jing Xu, Mengxiao Yu, Xuhui Ning, Yingyu Huang, Bujie Du, Elizabeth Hernandez, Payal Kapur, Jer‐Tsong Hsieh, and Jie Zheng
- Subjects
General Medicine - Published
- 2019
11. Tuning the In Vivo Transport of Anticancer Drugs Using Renal-Clearable Gold Nanoparticles
- Author
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Bujie Du, Jie Zheng, Jer Tsong Hsieh, Payal Kapur, Jing Xu, Chuanqi Peng, Yingyu Huang, Elizabeth Hernandez, Xuhui Ning, and Mengxiao Yu
- Subjects
Drug ,Tumor targeting ,Surface Properties ,media_common.quotation_subject ,Metal Nanoparticles ,Enhanced permeability and retention effect ,010402 general chemistry ,Kidney ,01 natural sciences ,Catalysis ,Article ,Mice ,Drug Delivery Systems ,In vivo ,medicine ,Distribution (pharmacology) ,Animals ,Humans ,Doxorubicin ,Particle Size ,media_common ,Cell Proliferation ,Antibiotics, Antineoplastic ,Molecular Structure ,010405 organic chemistry ,Chemistry ,Optical Imaging ,Mammary Neoplasms, Experimental ,General Chemistry ,0104 chemical sciences ,Colloidal gold ,Drug delivery ,Cancer research ,MCF-7 Cells ,Gold ,medicine.drug - Abstract
Precise control of in vivo transport of anticancer drugs in normal and cancerous tissues with engineered nanoparticles is key to future successes of cancer nanomedicines in clinics, which demands us to fundamentally understand how engineered nanoparticles impact the targeting-clearance and permeation-retention paradoxes in the anticancer drug delivery. Using a widely used anticancer drug, doxorubicin, as model, we systematically investigated how renal-clearable gold nanoparticles (AuNPs) affect the permeation, distribution and retention of drug in both cancerous and normal tissues. Our results show that renal-clearable AuNPs retain the strength of free drug in rapid tumor targeting with high tumor vascular permeability. Along with the enhanced tumor delivery and efficacy, the renal-clearable AuNPs also accelerated body clearance of “off-target” drug via renal elimination. These results clearly indicate that diverse in vivo transport behaviors of engineered nanoparticles can be used to reconcile long-standing paradoxes in the anticancer drug delivery.
- Published
- 2019
12. Dimerization of Organic Dyes on Luminescent Gold Nanoparticles for Ratiometric pH Sensing
- Author
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Greg Zhang, Xuhui Ning, Jie Zheng, Chuanqi Peng, Yen Chung Wang, and Shasha Sun
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Luminescence ,Metal Nanoparticles ,Protonation ,02 engineering and technology ,Photochemistry ,010402 general chemistry ,01 natural sciences ,Article ,Catalysis ,chemistry.chemical_compound ,Microscopy, Electron, Transmission ,Surface charge ,Fluorescein ,Coloring Agents ,Metal nanoparticles ,Chemistry ,010405 organic chemistry ,General Chemistry ,General Medicine ,Hydrogen-Ion Concentration ,021001 nanoscience & nanotechnology ,Fluorescence ,0104 chemical sciences ,Spectrometry, Fluorescence ,Colloidal gold ,Ph sensing ,Gold ,0210 nano-technology ,Dimerization - Abstract
Synergistic effects arising from the conjugation of organic dyes onto non-luminescent metal nanoparticles (NPs) have greatly broadened their applications in both imaging and sensing. Herein, we report that conjugation of a well-known pH-insensitive dye, tetramethyl-rhodamine (TAMRA), to pH-insensitive luminescent gold nanoparticles (AuNPs) can lead to an ultrasmall nanoindicator that can fluorescently report local pH in a ratiometric way. Such synergy originated from the dimerization of TAMRA on AuNPs, of which geometry was very sensitive to surface charges of the AuNPs and can be reversely modulated through protonation of surrounding glutathione ligands. Not limited to pH-insensitive dyes, this pH-dependent dimerization can also enhance the pH sensitivity of fluorescein, a well-known pH-sensitive dye, within a larger pH range, opening up a new pathway to design ultrasmall fluorescent ratiometric nanoindicators with tunable wavelengths and pH response ranges.
- Published
- 2016
13. Enhancing ZnO nanowire gas sensors using Au/Fe2O3 hybrid nanoparticle decoration
- Author
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Xingxu Lu, Can Cui, Pu-Xian Gao, Chuanqi Peng, Sibo Wang, Bo Zhang, Jie Zheng, Rodrigo D. Vinluan, Yingyu Huang, and Mingwan Zhang
- Subjects
Materials science ,Schottky barrier ,Iron oxide ,Nanowire ,Nanoparticle ,Bioengineering ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,chemistry.chemical_compound ,General Materials Science ,Thermal stability ,Electrical and Electronic Engineering ,business.industry ,Mechanical Engineering ,Schottky diode ,Heterojunction ,General Chemistry ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Semiconductor ,chemistry ,Mechanics of Materials ,0210 nano-technology ,business - Abstract
Heterojunctions are an important strategy for designing high performance electrical sensor materials and related devices. Herein, a new type of metal-semiconductor hybrid nanoparticle has been successfully used to remarkably sensitize the surface of ZnO nanowires for detecting NO2 with high responses over a broad temperature window ranging from room temperature to 600 °C. These hybrid nanoparticles are comprised of iron oxide nanowires with well dispersed single crystalline Au nanoparticles. The hybrid nanoparticle decorated ZnO nanowires have achieved a giant response, as high as 74 500 toward NO2 gas, about 42 times that of Au decorated ZnO nanowire sensors. This dramatic enhancement may be attributed to the efficient charge transfer across the Au-Fe2O3 Schottky and Fe2O3-ZnO semiconductor heterojunction interfaces. Due to the incorporation of thermally-stable Fe2O3 nanoparticles as the support of Au nanoparticles, the working temperature of nanowire sensors was successfully extended to higher temperatures, with an increase of 200 °C, from 400 °C to 600 °C. Such a combination of semiconductor heterojunction and semiconductor-metal Schottky contact presents a new strategy for designing high performance electrical sensors with high sensitivity, stability, selectivity, and wide operation temperature window, which are potentially suitable for advanced energy systems such as automotive engines and power plants.
- Published
- 2020
14. Biphenyl Wrinkled Mesoporous Silica Nanoparticles for pH-Responsive Doxorubicin Drug Delivery
- Author
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Chuanqi Peng, Jason Lin, Kenneth J. Balkus, A. K. M. Nur Alam Siddiki, Sanjana Ravi, and Jie Zheng
- Subjects
Nanoparticle ,02 engineering and technology ,wrinkled mesoporous silica ,010402 general chemistry ,lcsh:Technology ,doxorubicin ,01 natural sciences ,Article ,chemistry.chemical_compound ,medicine ,General Materials Science ,Doxorubicin ,lcsh:Microscopy ,Cytotoxicity ,pH selective ,lcsh:QC120-168.85 ,Biphenyl ,lcsh:QH201-278.5 ,lcsh:T ,Mesoporous silica ,021001 nanoscience & nanotechnology ,Fluorescence ,0104 chemical sciences ,chemistry ,lcsh:TA1-2040 ,drug delivery ,Drug delivery ,lcsh:Descriptive and experimental mechanics ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,Particle size ,lcsh:Engineering (General). Civil engineering (General) ,0210 nano-technology ,lcsh:TK1-9971 ,Nuclear chemistry ,medicine.drug - Abstract
Biphenyl wrinkled mesoporous silica nanoparticles with controlled particle size and high surface area were evaluated for the storage and delivery of doxorubicin. The average particle size and surface area were ~70 nm and ~1100 m2/g. The doxorubicin loading efficiency was 38.2 ±, 1.5 (w/w)% and the release was pH dependent. The breast cancer cell line, MCF-7 (Michigan Cancer Foundation-7) was used for the in vitro drug release study. The cytotoxicity of doxorubicin-loaded nanoparticles was significantly higher than free doxorubicin. Fluorescence images showed biphenyl wrinkled mesoporous silica (BPWS) uptake by the MCF-7 cells. The biphenyl bridged wrinkled silica nanoparticles appear promising for hydrophobic drug loading and delivery.
- Published
- 2020
15. Control of occlusion of middle cerebral artery in perinatal and neonatal mice with magnetic force
- Author
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Yihui Wang, Chuanqi Peng, Jie-Min Jia, Woo Ping Ge, and Jie Zheng
- Subjects
Magnetic force ,0301 basic medicine ,medicine.medical_specialty ,Neurology ,lcsh:RC346-429 ,Brain Ischemia ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Distal MCA ,medicine.artery ,Internal medicine ,Occlusion ,medicine ,Perinatal stroke ,Animals ,Ischemic neonatal stroke ,SIMPLE ,cardiovascular diseases ,Magnetite Nanoparticles ,Postnatal day ,Molecular Biology ,Stroke ,lcsh:Neurology. Diseases of the nervous system ,Neurons ,business.industry ,Cerebral infarction ,Magnetic Phenomena ,Superficial Temporal Vein ,Ischemic perinatal stroke ,Methodology ,Infarction, Middle Cerebral Artery ,medicine.disease ,3. Good health ,Mice, Inbred C57BL ,030104 developmental biology ,Animals, Newborn ,Magnetic nanoparticles ,Middle cerebral artery ,Cardiology ,Microglia ,business ,030217 neurology & neurosurgery - Abstract
Ischemic perinatal stroke (IPS) is common, resulting in significant mortality and morbidity. In such cases, the incidence of unilateral arterial cerebral infarction is often occluded in the middle cerebral artery (MCA), leading to focal ischemia. In adult rodents, blockage of MCA is the most frequently used strategy for ischemic stroke study. However, modeling MCA occlusion (MCAo) in postnatal day 0–7 (P0–7) mouse pups for IPS study has not been accomplished. Here we occluded the dMCA by inducing the accumulation of magnetic particles (MPs) administered through the superficial temporal vein of mice between P0 and P7, which we called neonatal or perinatal SIMPLE (Stroke Induced with Magnetic Particles). SIMPLE produced either permanent or transient occlusion in the dMCA of perinatal and neonatal mice. Permanent MCA occlusion with SIMPLE resulted in cerebral infarction and neuronal death in the brain. SIMPLE can also be used to reliably produce focal ischemic stroke in neonatal or perinatal mouse brains. As a result, SIMPLE allows the modeling of IPS or focal ischemic stroke for further mechanistic studies in mice, with particular utility for mimicking transient focal ischemia in human pre-term babies, which for the first time here has been accomplished in mice. Electronic supplementary material The online version of this article (10.1186/s13041-018-0389-0) contains supplementary material, which is available to authorized users.
- Published
- 2018
16. Dose Dependencies and Biocompatibility of Renal Clearable Gold Nanoparticles: From Mice to Non-human Primates
- Author
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Phoebe Carter, Xudong Zhao, Qinhan Zhou, Xuhui Ning, Qiu Tu, Jer Tsong Hsieh, Payal Kapur, Greg Zhang, Jing Xu, Jie Zheng, Chuanqi Peng, Jia Tian, Xingya Jiang, Anthony Dao, Mengxiao Yu, and Pengyu Liu
- Subjects
Biocompatibility ,Metal Nanoparticles ,Biocompatible Materials ,02 engineering and technology ,Pharmacology ,010402 general chemistry ,Kidney ,01 natural sciences ,Catalysis ,Article ,Mice ,Pharmacokinetics ,Species Specificity ,In vivo ,Animals ,Tissue Distribution ,Adverse effect ,No-Observed-Adverse-Effect Level ,Dose-Response Relationship, Drug ,010405 organic chemistry ,Chemistry ,General Medicine ,General Chemistry ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Macaca fascicularis ,Colloidal gold ,Renal physiology ,Area Under Curve ,Toxicity ,Gold ,0210 nano-technology ,Clearance ,Glomerular Filtration Rate - Abstract
While dose dependencies in pharmacokinetics and clearance are often observed in clinically used small molecules, very few studies have been dedicated to the understandings of potential dose-dependent in vivo transport of nanomedicines. Here we report that the pharmacokinetics and clearance of renal clearable gold nanoparticles (GS-AuNPs) are strongly dose-dependent once injection doses are above 15 mg kg-1 : high dose expedited the renal excretion and shortened the blood retention. As a result, the no-observed-adverse-effect-level (NOAEL) of GS-AuNPs was >1000 mg kg-1 in CD-1 mice. The efficient renal clearance and high compatibility can be translated to the non-human primates: no adverse effects were observed within 90 days after intravenous injection of 250 mg kg-1 GS-AuNPs. These fundamental understandings of dose effect on the in vivo transport of ultrasmall AuNPs open up a pathway to maximize their biomedical potentials and minimize their toxicity in the future clinical translation.
- Published
- 2017
17. Renal clearable noble metal nanoparticles: photoluminescence, elimination, and biomedical applications
- Author
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Jing Xu, Mengxiao Yu, Chuanqi Peng, and Jie Zheng
- Subjects
Materials science ,Biomedical Engineering ,Contrast Media ,Metal Nanoparticles ,Medicine (miscellaneous) ,Nanoparticle ,Bioengineering ,Nanotechnology ,02 engineering and technology ,Cancer targeting ,engineering.material ,Kidney ,010402 general chemistry ,01 natural sciences ,Article ,Drug Delivery Systems ,Neoplasms ,Humans ,Luminescent Agents ,Metal nanoparticles ,Kidney metabolism ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Key factors ,Molecular Probes ,engineering ,Noble metal ,0210 nano-technology ,Clearance - Abstract
Metal nanoparticles have demonstrated broad and promising biomedical applications in research laboratories, but how to fulfill their promises in the clinical practices demands extensive effort to minimize their non-specific accumulation in the body. In the past 6 years, we have developed a class of renal clearable noble metal nanoparticles with tunable visible and near-infrared emission, which can behave like small molecular contrast agents to be effectively eliminated through the kidneys. By taking advantage of the unique clearance pathway, we were able to gain some fundamental understanding of how engineering nanoparticles cleared out of the body through urinary system. Moreover, they also provided unique opportunities in early cancer detection and kidney functional imaging that were often challenging to be achieved with non-renal clearable nanoparticles and small molecular probes. In this review, we summarize key factors that govern in the renal clearance of luminescent noble metal nanoparticles and their strengths in cancer targeting and kidney functional imaging. At the end, we also outline several key challenges that need to be addressed before they can be considered in the clinical practices. WIREs Nanomed Nanobiotechnol 2017, 9:e1453. doi: 10.1002/wnan.1453 For further resources related to this article, please visit the WIREs website.
- Published
- 2017
18. Tailoring Renal Clearance and Tumor Targeting of Ultrasmall Metal Nanoparticles with Particle Density
- Author
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Rodrigo D. Vinluan, Qingxiao Wang, Jie Zheng, Mengxiao Yu, Bujie Du, Chuanqi Peng, Shaoheng Tang, Jing Xu, and Moon J. Kim
- Subjects
Tumor targeting ,Silver ,Surface Properties ,Metal Nanoparticles ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,Kidney ,01 natural sciences ,Catalysis ,Article ,Nanomaterials ,In vivo ,Phase (matter) ,Neoplasms ,Humans ,Particle Size ,Particle density ,Metal nanoparticles ,Chemistry ,General Chemistry ,General Medicine ,021001 nanoscience & nanotechnology ,Glutathione ,0104 chemical sciences ,Particle ,Gold ,0210 nano-technology ,Clearance - Abstract
Identifying key factors that govern in vivo behaviors of nanomaterials is critical to future clinical translation of nanomedicines. Shadowed by size-, shape- and surface-chemistry effects, the impact of particle core density on clearance and tumor targeting of inorganic nanoparticles (NPs) remains largely unknown. By utilizing a class of ultrasmall metal NPs with the same size and surface chemistry but different densities as model, we found that both renal clearance and passive tumor targeting of the NPs are strongly correlated with their densities: with the decrease of particle density, renal-clearance efficiency exponentially increased in the early elimination phase but passive tumor targeting was linearly decreased. Through systematic investigation on their pharmacokinetics, biodistribution and kidney filtration, we found that lower density NPs more easily distribute in the body and have shorter retention in highly permeable organs such as kidneys than the higher ones. These density-dependent in vivo behaviors are likely due to the fact that high-density AuNPs marginated to the blood vessel walls more quickly than low-density NPs; as a result, they circulated slowly in the laminar blood flow than the low-density ones. These new findings highlight the importance of particle density in tailoring of in vivo behaviors of engineering NPs and might open up a new pathway for designing nanomedicines with desired functionalities together with other key factors.
- Published
- 2016
19. Physiological stability and renal clearance of ultrasmall zwitterionic gold nanoparticles: Ligand length matters
- Author
-
Jing Xu, Chuanqi Peng, Xuhui Ning, Rodrigo D. Vinluan, Eric S. Li, Jie Zheng, and Mengxiao Yu
- Subjects
Materials science ,Stereochemistry ,lcsh:Biotechnology ,Nanoparticle ,02 engineering and technology ,01 natural sciences ,lcsh:TP248.13-248.65 ,medicine ,General Materials Science ,Surface charge ,Kidney ,010405 organic chemistry ,Molecular biophysics ,General Engineering ,Invited Letters ,021001 nanoscience & nanotechnology ,Ligand (biochemistry) ,lcsh:QC1-999 ,3. Good health ,0104 chemical sciences ,medicine.anatomical_structure ,SPECIAL TOPIC: FEW-ATOM METAL NANOCLUSTERS AND THEIR BIOLOGICAL APPLICATION ,Colloidal gold ,Biophysics ,Nanomedicine ,0210 nano-technology ,lcsh:Physics ,Cysteine - Abstract
Efficient renal clearance has been observed from ultrasmall zwitterionic glutathione-coated gold nanoparticles (GS-AuNPs), which have broad preclinical applications in cancer diagnosis and kidney functional imaging. However, origin of such efficient renal clearance is still not clear. Herein, we conducted head-to-head comparison on physiological stability and renal clearance of two zwitterionic luminescent AuNPs coated with cysteine and glycine-cysteine (Cys-AuNPs and Gly-Cys-AuNPs), respectively. While both of them exhibited similar surface charges and the same core sizes, additional glycine slightly increased the hydrodynamic diameter of the AuNPs by 0.4 nm but significantly enhanced physiological stability of the AuNPs as well as altered their clearance pathways. These studies indicate that the ligand length, in addition to surface charges and size, also plays a key role in the physiological stability and renal clearance of ultrasmall zwitterionic inorganic NPs.
- Published
- 2017
20. Physiological stability and renal clearance of ultrasmall zwitterionic gold nanoparticles: Ligand length matters.
- Author
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Ning X, Peng, Li ES, Xu J, Vinluan III RD, Yu M, and Zheng J
- Published
- 2017
- Full Text
- View/download PDF
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