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137 results on '"Chun, Hyejin"'

8. Decreased estimated glomerular filtration rate increase the risk of pancreatic cancer: A nationwide retrospective cohort study.

Author

Shin, Soonsu, Kim, Min‐Ho, Lee, Dong‐Young, Chun, Hyejin, Ha, Eunhee, Lee, Hyo Choon, Moon, Seong‐Ho, Lee, Sangho, and Ryoo, Jae‐Hong

Subjects
GLOMERULAR filtration rate, PANCREATIC cancer, DISEASE risk factors, PROPORTIONAL hazards models, NATIONAL health insurance
Abstract

Background and Aim: Decreased kidney function is a putative risk factor for various cancers. However, few studies have investigated the association between a decreased estimated glomerular filtration rate (eGFR) and incident pancreatic cancer. We aimed to investigate the risk of incident pancreatic cancer according to eGFR categories. Methods: In this retrospective cohort study, we included 359 721 adults who underwent health checkups in 2009 or 2010 by using the Korean National Health Insurance Database. The study population was categorized into four groups by eGFR (mL/min/1.73 m2) using the Chronic Kidney Disease Epidemiology Collaboration equation: group 1 (eGFR < 45), group 2 (eGFR ≥ 45 to < 60), group 3 (eGFR ≥ 60 to < 90), and group 4 (eGFR ≥ 90). Multivariate Cox proportional hazards models were used to determine the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of pancreatic cancer until 2019 by comparing the eGFR groups. Results: During the 3 493 589.05 person‐years of follow‐up, 1702 pancreatic cancer cases were identified. Compared with group 4 (eGFR ≥ 90), HRs and 95% CIs for the incidence of pancreatic cancer were 1.39 (1.24–1.56) for group 3 (eGFR ≥ 60 to < 90), 1.79 (1.47–2.16) for group 2 (eGFR ≥ 45 to < 60), and 2.05 (1.62–2.60) for group 1 (eGFR < 45) in the multivariate adjusted model. Conclusions: Decreased eGFR was significantly associated with an increased risk of pancreatic cancer in Korean population. Further studies are needed to investigate the relationship between a decreased eGFR and the risk of pancreatic cancer in other ethnic groups. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Potentially inappropriate prescribing of cardiovascular system and antiplatelet/anticoagulant drugs among elderly patients: a Korean population-based national study

Author

Kim, Jongyeon, Han, Euna, Hwang, Hee-Jin, Cho, Hyeonseok, Kim, Young-Sang, Chun, Hyejin, Kim, Jinkwon, Park, Yon Chul, and Kang, Hye-Young

Subjects
Reseach Article
Abstract

OBJECTIVES To investigate the prevalence of potentially inappropriate prescribing (PIP) for cardiovascular system (CVS) and antiplatelet/anticoagulant (AP/AC) drugs among Korean elderly patients, using the Screening Tool of Older Persons’ Prescriptions (STOPP) criteria version 2 and to identify the risk factors related to PIP. METHODS The 2016 National Aged Patient Sample data, comprising National Health Insurance claim records for a random sample of 20% of patients aged ≥ 65 years, were used to calculate PIP prevalence of outpatient prescriptions. For criteria including drug-disease interactions, PIP prevalence per indication was estimated. RESULTS Among 1,274,148 elderly patients and 27,062,307 outpatient prescription claims, 100,085 patients (7.85%) and 341,664 claims (1.27%) had one or more PIP. The most frequent PIP was “non-steroidal anti-inflammatory drug with concurrent antiplatelet agent (s) without proton-pump inhibitor prophylaxis” in the claim-level (0.97%) and patient-level (6.33%) analyses. “Beta-blocker with bradycardia” (16.47% of claims) and “angiotensin receptor blockers in patients with hyperkalaemia” (23.89% of claims) showed the highest PIP prevalence per indication. Logistic regression analysis revealed that, among the patient and health care provider characteristics, female, older age, more severe comorbidities, polypharmacy, higher level of healthcare organization, and specialty of prescriber were significantly associated with a higher risk of PIP. CONCLUSIONS Our findings of a high prevalence of PIP for CVS and AP/AC drugs among the elderly suggest that an effective strategy is urgently needed to improve the prescription practices of these drugs.

Published
2021

30. Characteristics of metabolic factors related to arterial stiffness in young and old adults.

Author

Won, Bo Youn, Park, Seung Geon, Lee, Soo-Hyun, Kim, Moon-Jong, Chun, Hyejin, Hong, Doohee, and Kim, Young-Sang

Subjects
OLDER people, ARTERIAL diseases, YOUNG adults, APOLIPOPROTEIN B, LIVER enzymes
Abstract

It has not been adequately studied which biomarkers for cardiovascular risk indicate changes of atherosclerosis by aging process. The current study aimed to investigate the characteristics of metabolic factors related to arterial stiffness in young and old adults. Our cross-sectional study enrolled 851 healthy young adults and 719 old adults. Metabolic biomarkers included glucose, lipid profiles, and liver enzymes. In young adults, additional biomarkers such as C-reactive protein, apolipoproteins, lipoprotein(a), ferritin, and 25-hydroxycholecalciferol were measured. Arterial stiffness was evaluated by measuring brachial-ankle pulse wave velocity (baPWV). The mean age was 37.8 and 65.1 years old in the young and old groups, respectively. Without adjustment, most parameters were significantly correlated with baPWV in both young and old groups. Mean baPWV was significantly different according to metabolic syndrome (MetS) in both groups (13.1 and 12.1 m/s in the young subjects with and without MetS, respectively; 17.4 and 15.8 m/s, respectively, in the old group). After adjusting for age, sex, and hemodynamic factors, the difference in baPWV according to MetS was significant only in the old group. The relationship between most biomarkers and baPWV was influenced by metabolic disorders such as hypertension and diabetes in old adults. Total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), and apolipoprotein B were significant in young group. In conclusion, the metabolic biomarkers related to arterial stiffness were different between young and old adults. Contrary to old adults, TC, LDLC, and apolipoprotein B were independent biomarkers for arterial stiffness in healthy young adults. [ABSTRACT FROM AUTHOR]

Published
2020
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45. A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men

Author

Park, Sung Keun, primary, Chun, Hyejin, additional, Ryoo, Jae-Hong, additional, Lee, Sang Wha, additional, Lee, Hong Soo, additional, Shim, Kyung Won, additional, Cho, Choo Yon, additional, Ryu, Dong-Ryeol, additional, Ko, Taeg Su, additional, Kim, Eugene, additional, Park, Se-Jin, additional, Park, Jai Hyung, additional, Hong, Seok Jin, additional, and Hong, Hyun Pyo, additional

Published
2015
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