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1. Efficacy of Oral Sulfate Tablet and 2 L-Polyethylene Glycol With Ascorbic Acid for Bowel Preparation: A Prospective Randomized KASID Multicenter Trial.

Author

Jung, Yunho, Kim, Hyun, Yang, Dong-Hoon, Kang, Hyoun, Park, Jae, Baek, Dong, Chun, Jaeyoung, Gweon, Tae-Geun, Goong, Hyeon, Kwak, Min Seob, Lee, Hyun, Park, Soo-Kyung, and Lee, Jong

Subjects
Bowel Preparation, Colonoscopy, Polyethylene Glycol, Sulfate, Humans, Polyethylene Glycols, Ascorbic Acid, Female, Male, Cathartics, Colonoscopy, Adult, Prospective Studies, Middle Aged, Tablets, Administration, Oral, Sulfates, Single-Blind Method
Abstract

BACKGROUND: Oral sulfate tablets (OSTs) are bowel preparation agents that combine oral sulfate solution and simethicone. This study compared the efficacy, tolerability, and safety of OST compared to 2 L-polyethylene glycol plus ascorbic acid (2 L-PEG/ASC). METHODS: This prospective, randomized, controlled, single-blinded, multicenter, noninferiority trial enrolled 211 healthy adults who underwent colonoscopy between May 2020 and September 2022 at 13 university hospitals. The bowel cleansing rate was assessed using the Boston Bowel Preparation Scale (BBPS) and Harefield Cleansing Scale (HCS), and the preparation agents were administered in split regimens. RESULTS: The total BBPS score (8.2 ± 1.5 vs. 7.8 ± 1.4, p = 0.040) and the high-quality bowel cleansing rates in the right colon (73.2% vs. 50.5), transverse colon (80.6% vs. 68.0%), and left colon (81.5% vs. 67.0%) on the BBPS were significantly higher in the OST group than in the 2 L-PEG/ASC group. However, the rates of successful cleansing according to BBPS (90.7% vs. 91.2%) and HCS (96.3% vs. 94.2%) did not significantly differ between the two groups. The taste, ease, and amount of consumption of the preparation agent; and willingness to repeat colonoscopy with the same agent (89.8% vs. 78.6%, P = 0.026) were significantly better in the OST group compared to the 2 L-PEG/ASC group. Adverse events and clinically significant laboratory changes were not significantly different between the two groups. CONCLUSION: The OST was not inferior to 2 L-PEG/ASC in terms of bowel cleansing efficacy and showed better tolerability when used for bowel preparation for colonoscopy. TRIAL REGISTRATION: Clinical Research Information Service Identifier: KCT0005017.

Published
2024

2. A survey of current practices in post-polypectomy surveillance in Korea.

Author

Kim, Jeongseok, Gweon, Tae-Geun, Kwak, Min Seob, Kim, Su, Kim, Seong, Kim, Hyun, Kim, Eun, Hong, Sung, Moon, Chang, Myung, Dae, Baek, Dong, Oh, Shin, Lee, Hyun, Lee, Ji, Jung, Yunho, Chun, Jaeyoung, and Yang, Dong-Hoon

Subjects
Colon, Colonic polyps, Colonoscopy, Rectum
Abstract

BACKGROUND/AIMS: We investigated the clinical practice patterns of post-polypectomy colonoscopic surveillance among Korean endoscopists. METHODS: In a web-based survey conducted between September and November 2021, participants were asked about their preferred surveillance intervals and the patient age at which surveillance was discontinued. Adherence to the recent guidelines of the U.S. Multi-Society Task Force on Colorectal Cancer (USMSTF) was also analyzed. RESULTS: In total, 196 endoscopists completed the survey. The most preferred first surveillance intervals were: a 5-year interval after the removal of 1-2 tubular adenomas < 10 mm; a 3-year interval after the removal of 3-10 tubular adenomas < 10 mm, adenomas ≥ 10 mm, tubulovillous or villous adenomas, ≤ 20 hyperplastic polyps < 10 mm, 1-4 sessile serrated lesions (SSLs) < 10 mm, hyperplastic polyps or SSLs ≥ 10 mm, and traditional serrated adenomas; and a 1-year interval after the removal of adenomas with highgrade dysplasia, >10 adenomas, 5-10 SSLs, and SSLs with dysplasia. In piecemeal resections of large polyps ( > 20 mm), surveillance colonoscopy was mostly preferred after 1 year for adenomas and 6 months for SSLs. The mean USMSTF guideline adherence rate was 30.7%. The largest proportion of respondents (40.8%-55.1%) discontinued the surveillance at the patient age of 80-84 years. CONCLUSIONS: A significant discrepancy was observed between the preferred post-polypectomy surveillance intervals and recent international guidelines. Individualized measures are required to increase adherence to the guidelines.

Published
2024

4. Korean Guidelines for Postpolypectomy Colonoscopic Surveillance: 2022 revised edition.

Author

Kim, Su, Kwak, Min, Yoon, Soon, Jung, Yunho, Kim, Jong, Boo, Sun-Jin, Oh, Eun, Jeon, Seong, Nam, Seung-Joo, Park, Seon-Young, Park, Soo-Kyung, Chun, Jaeyoung, Baek, Dong, Choi, Mi-Young, Park, Suyeon, Byeon, Jeong-Sik, Kim, Hyung, Cho, Joo, Lee, Moon, and Lee, Oh

Subjects
Colonoscopy, Colorectal cancer, Guidelines, Polypectomy, Surveillance
Abstract

Colonoscopic polypectomy is effective in decreasing the incidence and mortality of colorectal cancer (CRC). Premalignant polyps discovered during colonoscopy are associated with the risk of metachronous advanced neoplasia. Postpolypectomy surveillance is the most important method for managing advanced metachronous neoplasia. A more efficient and evidence-based guideline for postpolypectomy surveillance is required because of the limited medical resources and concerns regarding colonoscopy complications. In these consensus guidelines, an analytic approach was used to address all reliable evidence to interpret the predictors of CRC or advanced neoplasia during surveillance colonoscopy. The key recommendations state that the high-risk findings for metachronous CRC following polypectomy are as follows: adenoma ≥10 mm in size; 3 to 5 (or more) adenomas; tubulovillous or villous adenoma; adenoma containing high-grade dysplasia; traditional serrated adenoma; sessile serrated lesion containing any grade of dysplasia; serrated polyp of at least 10 mm in size; and 3 to 5 (or more) sessile serrated lesions. More studies are needed to fully comprehend the patients who are most likely to benefit from surveillance colonoscopy and the ideal surveillance interval to prevent metachronous CRC.

Published
2023

5. Efficacy and safety of 48 weeks of guselkumab for patients with Crohn's disease: maintenance results from the phase 2, randomised, double-blind GALAXI-1 trial

Author

Oliinyk, Oleksandr, Bilianskyi, Leonid, Gniady-Jastrzebska, Jadwiga, Petryka, Robert, Arlukowicz, Tomasz, Gietka, Piotr, Zmudzinski, Marcin, Mumtaz, Syed, Wolf, Douglas, Wojcik, Katarzyna, Duvall, George, Augustyn, Monika, Filip, Rafal, Tarabar, Dino, Tkachev, Alexander, Seidler, Ursula, Zittan, Eran, Pokrotnieks, Juris, Shchukina, Oksana, Machavariani, Andro, Loy, Laura, Abu-farsakh, Niazy, Marina, Pesegova, Sreckovic, Slobodan, Laclav, Martin, Wei, Shu-Chen, Suiter, Daniel, Borsuk, Aleksey, Hebuterne, Xavier, Buning, Carsten, Lahat-Zok, Adi, Danilkiewicz, Wit, Frysna, Bernadetta, Jovicic, Ivana, Datsenko, Olena, Guram, Maninder, Jain, Animesh, Rashid, Zahid, Heeren, Sonja, Shulga, Natallia, Timkin, Ivan, Gornjakovic, Srdjan, Lukas, Milan, Altwegg, Romain, Desjeux, Ariadne, Reimund, Jean-Marie, Giorgadze, Manana, Jochum, Christoph, Ito, Hiroaki, Nakai, Katsuhiko, Takagi, Tomohisa, Zaha, Osamu, Choi, Changhwan, Kim, Taeoh, Lee, Jonghun, Stundiene, Ieva, Hilmi, Ida Normiha, Hj Md Said, Rosaida, Leszczyszyn, Jaroslaw, Abdulganieva, Diana, Fominykh, Yulia, Maksyashina, Svetlana, Balaz, Jozef, Van Domselaar, Manuel, Kav, Taylan, Dennis, Patrick, Henry, Patricia, Holmes, Robert, Johnson, Christopher, McBride, Matthew, Sarles, Harry, Moore, Gregory, Yakubtsevich, Ruslan, Muls, Vinciane, Trbojevic, Stevan, Afif, Waqqas, Bernstein, Charles, Klarin, Ivo, Serclova, Zuzana, Volfova, Miroslava, Desreumaux, Pierre, Gilletta de Saint Joseph, Cyrielle, Roblin, Xavier, Vuitton, Lucine, Chelidze, Kakhaber, Kuehbacher, Tanja, Koutroubakis, Ioannis, Cicala, Michele, Fries, Walter, Gasbarrini, Antonio, Aoyama, Nobuo, Hayashi, Yoshito, Hirai, Fumihito, Horiki, Norkiyuki, Hoshi, Namiko, Inaba, Tomoki, Hiroyasu, Ishida, Maemoto, Atsuo, Matsumoto, Takayuki, Matsushima, Kayoko, Motoya, Satoshi, Taruishi, Masaki, Rashid, Mohammed, Chun, Jaeyoung, Kim, Young-Ho, Park, Dong Il, Sharara, Ala, Jonaitis, Laimas, Deriban, Gjorgi, Brooker, James, Gawdis-Wojnarska, Beata, Wozniak-Stolarska, Barbara, Andreev, Pavel, Simanenkov, Vladimir, Trofimov, Vasiliy, Jovanovic, Igor, Zdravkovic, Natasa, Aldeguer i Mante, Xavier, Hernandez Ramirez, Vicent, Akpinar, Hale, Celebi, Gurkan, Hamzaoglu, Hulya, Fernandez, Juan, Kamath, Jayaprakash, Palekar, Nicole, Pruthi, Jatinder S., Rausher, David, Ritter, Timothy, Danese, Silvio, Panaccione, Remo, Feagan, Brian G, Afzali, Anita, Rubin, David T, Sands, Bruce E, Reinisch, Walter, Panés, Julián, Sahoo, Aparna, Terry, Natalie A, Chan, Daphne, Han, Chenglong, Frustaci, Mary Ellen, Yang, Zijiang, Sandborn, William J, Hisamatsu, Tadakazu, Andrews, Jane M, and D'Haens, Geert R

Published
2024
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14. The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

Author

Aberle, Denise, Achilefu, Samuel I., Ademuyiwa, Foluso O., Adey, Andrew C., Aft, Rebecca L., Agarwal, Rachana, Aguilar, Ruben A., Alikarami, Fatemeh, Allaj, Viola, Amos, Christopher, Anders, Robert A., Angelo, Michael R., Anton, Kristen, Ashenberg, Orr, Aster, Jon C., Babur, Ozgun, Bahmani, Amir, Balsubramani, Akshay, Barrett, David, Beane, Jennifer, Bender, Diane E., Bernt, Kathrin, Berry, Lynne, Betts, Courtney B., Bletz, Julie, Blise, Katie, Boire, Adrienne, Boland, Genevieve, Borowsky, Alexander, Bosse, Kristopher, Bott, Matthew, Boyden, Ed, Brooks, James, Bueno, Raphael, Burlingame, Erik A., Cai, Qiuyin, Campbell, Joshua, Caravan, Wagma, Cerami, Ethan, Chaib, Hassan, Chan, Joseph M., Chang, Young Hwan, Chatterjee, Deyali, Chaudhary, Ojasvi, Chen, Alyce A., Chen, Bob, Chen, Changya, Chen, Chia-hui, Chen, Feng, Chen, Yu-An, Chheda, Milan G., Chin, Koei, Chiu, Roxanne, Chu, Shih-Kai, Chuaqui, Rodrigo, Chun, Jaeyoung, Cisneros, Luis, Coffey, Robert J., Colditz, Graham A., Cole, Kristina, Collins, Natalie, Contrepois, Kevin, Coussens, Lisa M., Creason, Allison L., Crichton, Daniel, Curtis, Christina, Davidsen, Tanja, Davies, Sherri R., de Bruijn, Ino, Dellostritto, Laura, De Marzo, Angelo, Demir, Emek, DeNardo, David G., Diep, Dinh, Ding, Li, Diskin, Sharon, Doan, Xengie, Drewes, Julia, Dubinett, Stephen, Dyer, Michael, Egger, Jacklynn, Eng, Jennifer, Engelhardt, Barbara, Erwin, Graham, Esplin, Edward D., Esserman, Laura, Felmeister, Alex, Feiler, Heidi S., Fields, Ryan C., Fisher, Stephen, Flaherty, Keith, Flournoy, Jennifer, Ford, James M., Fortunato, Angelo, Frangieh, Allison, Frye, Jennifer L., Fulton, Robert S., Galipeau, Danielle, Gan, Siting, Gao, Jianjiong, Gao, Long, Gao, Peng, Gao, Vianne R., Geiger, Tim, George, Ajit, Getz, Gad, Ghosh, Sharmistha, Giannakis, Marios, Gibbs, David L., Gillanders, William E., Goecks, Jeremy, Goedegebuure, Simon P., Gould, Alanna, Gowers, Kate, Gray, Joe W., Greenleaf, William, Gresham, Jeremy, Guerriero, Jennifer L., Guha, Tuhin K., Guimaraes, Alexander R., Guinney, Justin, Gutman, David, Hacohen, Nir, Hanlon, Sean, Hansen, Casey R., Harismendy, Olivier, Harris, Kathleen A., Hata, Aaron, Hayashi, Akimasa, Heiser, Cody, Helvie, Karla, Herndon, John M., Hirst, Gilliam, Hodi, Frank, Hollmann, Travis, Horning, Aaron, Hsieh, James J., Hughes, Shannon, Huh, Won Jae, Hunger, Stephen, Hwang, Shelley E., Iacobuzio-Donahue, Christine A., Ijaz, Heba, Izar, Benjamin, Jacobson, Connor A., Janes, Samuel, Jané-Valbuena, Judit, Jayasinghe, Reyka G., Jiang, Lihua, Johnson, Brett E., Johnson, Bruce, Ju, Tao, Kadara, Humam, Kaestner, Klaus, Kagan, Jacob, Kalinke, Lukas, Keith, Robert, Khan, Aziz, Kibbe, Warren, Kim, Albert H., Kim, Erika, Kim, Junhyong, Kolodzie, Annette, Kopytra, Mateusz, Kotler, Eran, Krueger, Robert, Krysan, Kostyantyn, Kundaje, Anshul, Ladabaum, Uri, Lake, Blue B., Lam, Huy, Laquindanum, Rozelle, Lau, Ken S., Laughney, Ashley M., Lee, Hayan, Lenburg, Marc, Leonard, Carina, Leshchiner, Ignaty, Levy, Rochelle, Li, Jerry, Lian, Christine G., Lim, Kian-Huat, Lin, Jia-Ren, Lin, Yiyun, Liu, Qi, Liu, Ruiyang, Lively, Tracy, Longabaugh, William J.R., Longacre, Teri, Ma, Cynthia X., Macedonia, Mary Catherine, Madison, Tyler, Maher, Christopher A., Maitra, Anirban, Makinen, Netta, Makowski, Danika, Maley, Carlo, Maliga, Zoltan, Mallo, Diego, Maris, John, Markham, Nick, Marks, Jeffrey, Martinez, Daniel, Mashl, Robert J., Masilionais, Ignas, Mason, Jennifer, Massagué, Joan, Massion, Pierre, Mattar, Marissa, Mazurchuk, Richard, Mazutis, Linas, Mazzilli, Sarah A., McKinley, Eliot T., McMichael, Joshua F., Merrick, Daniel, Meyerson, Matthew, Miessner, Julia R., Mills, Gordon B., Mills, Meredith, Mondal, Suman B., Mori, Motomi, Mori, Yuriko, Moses, Elizabeth, Mosse, Yael, Muhlich, Jeremy L., Murphy, George F., Navin, Nicholas E., Nawy, Tal, Nederlof, Michel, Ness, Reid, Nevins, Stephanie, Nikolov, Milen, Nirmal, Ajit Johnson, Nolan, Garry, Novikov, Edward, Oberdoerffer, Philipp, O’Connell, Brendan, Offin, Michael, Oh, Stephen T., Olson, Anastasiya, Ooms, Alex, Ossandon, Miguel, Owzar, Kouros, Parmar, Swapnil, Patel, Tasleema, Patti, Gary J., Pe’er, Dana, Pe'er, Itsik, Peng, Tao, Persson, Daniel, Petty, Marvin, Pfister, Hanspeter, Polyak, Kornelia, Pourfarhangi, Kamyar, Puram, Sidharth V., Qiu, Qi, Quintanal-Villalonga, Álvaro, Raj, Arjun, Ramirez-Solano, Marisol, Rashid, Rumana, Reeb, Ashley N., Regev, Aviv, Reid, Mary, Resnick, Adam, Reynolds, Sheila M., Riesterer, Jessica L., Rodig, Scott, Roland, Joseph T., Rosenfield, Sonia, Rotem, Asaf, Roy, Sudipta, Rozenblatt-Rosen, Orit, Rudin, Charles M., Ryser, Marc D., Santagata, Sandro, Santi-Vicini, Maria, Sato, Kazuhito, Schapiro, Denis, Schrag, Deborah, Schultz, Nikolaus, Sears, Cynthia L., Sears, Rosalie C., Sen, Subrata, Sen, Triparna, Shalek, Alex, Sheng, Jeff, Sheng, Quanhu, Shoghi, Kooresh I., Shrubsole, Martha J., Shyr, Yu, Sibley, Alexander B., Siex, Kiara, Simmons, Alan J., Singer, Dinah S., Sivagnanam, Shamilene, Slyper, Michal, Snyder, Michael P., Sokolov, Artem, Song, Sheng-Kwei, Sorger, Peter K., Southard-Smith, Austin, Spira, Avrum, Srivastava, Sudhir, Stein, Janet, Storm, Phillip, Stover, Elizabeth, Strand, Siri H., Su, Timothy, Sudar, Damir, Sullivan, Ryan, Surrey, Lea, Suvà, Mario, Tan, Kai, Terekhanova, Nadezhda V., Ternes, Luke, Thammavong, Lisa, Thibault, Guillaume, Thomas, George V., Thorsson, Vésteinn, Todres, Ellen, Tran, Linh, Tyler, Madison, Uzun, Yasin, Vachani, Anil, Van Allen, Eliezer, Vandekar, Simon, Veis, Deborah J., Vigneau, Sébastien, Vossough, Arastoo, Waanders, Angela, Wagle, Nikhil, Wang, Liang-Bo, Wendl, Michael C., West, Robert, Williams, Elizabeth H., Wu, Chi-yun, Wu, Hao, Wu, Hung-Yi, Wyczalkowski, Matthew A., Xie, Yubin, Yang, Xiaolu, Yapp, Clarence, Yu, Wenbao, Yuan, Yinyin, Zhang, Dadong, Zhang, Kun, Zhang, Mianlei, Zhang, Nancy, Zhang, Yantian, Zhao, Yanyan, Zhou, Daniel Cui, Zhou, Zilu, Zhu, Houxiang, Zhu, Qin, Zhu, Xiangzhu, Zhu, Yuankun, Zhuang, Xiaowei, Hupalowska, Anna, Rood, Jennifer E., Hanlon, Sean E., Hughes, Shannon K., Hwang, E. Shelley, Johnson, Bruce E., Shalek, Alex K., Spira, Avrum E., and West, Robert B.

Published
2020
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17. Efficacy and safety of 48 weeks of guselkumab for patients with Crohn's disease: maintenance results from the phase 2, randomised, double-blind GALAXI-1 trial

Author

Danese, Silvio, primary, Panaccione, Remo, additional, Feagan, Brian G, additional, Afzali, Anita, additional, Rubin, David T, additional, Sands, Bruce E, additional, Reinisch, Walter, additional, Panés, Julián, additional, Sahoo, Aparna, additional, Terry, Natalie A, additional, Chan, Daphne, additional, Han, Chenglong, additional, Frustaci, Mary Ellen, additional, Yang, Zijiang, additional, Sandborn, William J, additional, Hisamatsu, Tadakazu, additional, Andrews, Jane M, additional, D'Haens, Geert R, additional, Oliinyk, Oleksandr, additional, Bilianskyi, Leonid, additional, Gniady-Jastrzebska, Jadwiga, additional, Petryka, Robert, additional, Arlukowicz, Tomasz, additional, Gietka, Piotr, additional, Zmudzinski, Marcin, additional, Mumtaz, Syed, additional, Wolf, Douglas, additional, Wojcik, Katarzyna, additional, Duvall, George, additional, Augustyn, Monika, additional, Filip, Rafal, additional, Tarabar, Dino, additional, Tkachev, Alexander, additional, Seidler, Ursula, additional, Zittan, Eran, additional, Pokrotnieks, Juris, additional, Shchukina, Oksana, additional, Machavariani, Andro, additional, Loy, Laura, additional, Abu-farsakh, Niazy, additional, Marina, Pesegova, additional, Sreckovic, Slobodan, additional, Laclav, Martin, additional, Wei, Shu-Chen, additional, Suiter, Daniel, additional, Borsuk, Aleksey, additional, Hebuterne, Xavier, additional, Buning, Carsten, additional, Lahat-Zok, Adi, additional, Danilkiewicz, Wit, additional, Frysna, Bernadetta, additional, Jovicic, Ivana, additional, Datsenko, Olena, additional, Guram, Maninder, additional, Jain, Animesh, additional, Rashid, Zahid, additional, Heeren, Sonja, additional, Shulga, Natallia, additional, Timkin, Ivan, additional, Gornjakovic, Srdjan, additional, Lukas, Milan, additional, Altwegg, Romain, additional, Desjeux, Ariadne, additional, Reimund, Jean-Marie, additional, Giorgadze, Manana, additional, Jochum, Christoph, additional, Ito, Hiroaki, additional, Nakai, Katsuhiko, additional, Takagi, Tomohisa, additional, Zaha, Osamu, additional, Choi, Changhwan, additional, Kim, Taeoh, additional, Lee, Jonghun, additional, Stundiene, Ieva, additional, Hilmi, Ida Normiha, additional, Hj Md Said, Rosaida, additional, Leszczyszyn, Jaroslaw, additional, Abdulganieva, Diana, additional, Fominykh, Yulia, additional, Maksyashina, Svetlana, additional, Balaz, Jozef, additional, Van Domselaar, Manuel, additional, Kav, Taylan, additional, Dennis, Patrick, additional, Henry, Patricia, additional, Holmes, Robert, additional, Johnson, Christopher, additional, McBride, Matthew, additional, Sarles, Harry, additional, Moore, Gregory, additional, Yakubtsevich, Ruslan, additional, Muls, Vinciane, additional, Trbojevic, Stevan, additional, Afif, Waqqas, additional, Bernstein, Charles, additional, Klarin, Ivo, additional, Serclova, Zuzana, additional, Volfova, Miroslava, additional, Desreumaux, Pierre, additional, Gilletta de Saint Joseph, Cyrielle, additional, Roblin, Xavier, additional, Vuitton, Lucine, additional, Chelidze, Kakhaber, additional, Kuehbacher, Tanja, additional, Koutroubakis, Ioannis, additional, Cicala, Michele, additional, Fries, Walter, additional, Gasbarrini, Antonio, additional, Aoyama, Nobuo, additional, Hayashi, Yoshito, additional, Hirai, Fumihito, additional, Horiki, Norkiyuki, additional, Hoshi, Namiko, additional, Inaba, Tomoki, additional, Hiroyasu, Ishida, additional, Maemoto, Atsuo, additional, Matsumoto, Takayuki, additional, Matsushima, Kayoko, additional, Motoya, Satoshi, additional, Taruishi, Masaki, additional, Rashid, Mohammed, additional, Chun, Jaeyoung, additional, Kim, Young-Ho, additional, Park, Dong Il, additional, Sharara, Ala, additional, Jonaitis, Laimas, additional, Deriban, Gjorgi, additional, Brooker, James, additional, Gawdis-Wojnarska, Beata, additional, Wozniak-Stolarska, Barbara, additional, Andreev, Pavel, additional, Simanenkov, Vladimir, additional, Trofimov, Vasiliy, additional, Jovanovic, Igor, additional, Zdravkovic, Natasa, additional, Aldeguer i Mante, Xavier, additional, Hernandez Ramirez, Vicent, additional, Akpinar, Hale, additional, Celebi, Gurkan, additional, Hamzaoglu, Hulya, additional, Fernandez, Juan, additional, Kamath, Jayaprakash, additional, Palekar, Nicole, additional, Pruthi, Jatinder S., additional, Rausher, David, additional, and Ritter, Timothy, additional

Published
2024
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18. A gene–environment-induced epigenetic program initiates tumorigenesis

Author

Alonso-Curbelo, Direna, Ho, Yu-Jui, Burdziak, Cassandra, Maag, Jesper L. V., Morris, IV, John P., Chandwani, Rohit, Chen, Hsuan-An, Tsanov, Kaloyan M., Barriga, Francisco M., Luan, Wei, Tasdemir, Nilgun, Livshits, Geulah, Azizi, Elham, Chun, Jaeyoung, Wilkinson, John E., Mazutis, Linas, Leach, Steven D., Koche, Richard, Pe’er, Dana, and Lowe, Scott W.

Published
2021
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20. Enhancing Diagnosticconfidence and Accuracy in the Optical Diagnosis of Colorectal Polyps Using an Uncertainty-Aware Vision Transformer

Author

Lee, Youngwan, primary, Lee, Sangrok, additional, Jin, Eunhyo, additional, Lee, Dongheon, additional, Lee, Ji Young, additional, Chun, Jaeyoung, additional, Chang, Ji Young, additional, Kang, Hae Yeon, additional, Yang, Sun Young, additional, Lim, Seon Hee, additional, Chung, Goh Eun, additional, Chung, Su Jin, additional, Choi, Ji Min, additional, and Han, Yoo Min, additional

Published
2024
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22. Deep generative model deciphers derailed trajectories in acute myeloid leukemia

Author

Nazaret, Achille, primary, Fan, Joy Linyue, additional, Lavallee, Vincent-Philippe, additional, Cornish, Andrew E., additional, Kiseliovas, Vaidotas, additional, Masilionis, Ignas, additional, Chun, Jaeyoung, additional, Bowman, Robert L., additional, Eisman, Shira E., additional, Wang, James, additional, Shi, Lingting, additional, Levine, Ross L., additional, Mazutis, Linas, additional, Blei, David, additional, Pe'er, Dana, additional, and Azizi, Elham, additional

Published
2023
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26. Enrichment of Activated Fibroblasts as a Potential Biomarker for a Non-Durable Response to Anti-Tumor Necrosis Factor Therapy in Patients with Crohn’s Disease

Author

Park, Soo-Kyung, primary, Lee, Gi-Young, additional, Kim, Sangsoo, additional, Lee, Chil-Woo, additional, Choi, Chang-Hwan, additional, Kang, Sang-Bum, additional, Kim, Tae-Oh, additional, Chun, Jaeyoung, additional, Cha, Jae-Myung, additional, Im, Jong-Pil, additional, Ahn, Kwang-Sung, additional, Kim, Seon-Young, additional, Kim, Min-Suk, additional, Lee, Chang-Kyun, additional, and Park, Dong-Il, additional

Published
2023
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31. Abstract 1167: Single-cell transcriptomic profiling of SCLC transformation reveals increased intratumoral diversity of variant and non-neuroendocrine subtypes

Author

Chan, Joseph Minhow, primary, Quintanal-Villalonga, Alvaro, additional, Sabet, Amin, additional, Manoj, Parvathy, additional, Chaudhary, Ojasvi, additional, Xu, Tianhao, additional, Masilionis, Ignas, additional, Egger, Jacklynn, additional, Sohail, Noor, additional, Chun, Jaeyoung, additional, Nawy, Tal, additional, Mazutis, Linas, additional, Sen, Triparna, additional, Chaligne, Ronan, additional, Yu, Helena, additional, Pe'er, Dana, additional, and Rudin, Charles, additional

Published
2023
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41. Association of Waist Circumference with the Risk of Inflammatory Bowel Disease: a Nationwide Cohort Study of 10 Million Individuals in Korea.

Author

Je, Yeonjin, Han, Kyungdo, Chun, Jaeyoung, Kim, Yuna, Kim, Jie-Hyun, Youn, Young Hoon, Park, Hyojin, Im, Jong Pil, and Kim, Joo Sung

Abstract

Background and Aims Metabolic syndrome may share the pathophysiology of adipose tissue dysregulation and inadequate immune response with inflammatory bowel disease [IBD]. We determined the association of abdominal obesity [AO] with the risk of developing IBD. Methods We conducted a nationwide population-based cohort study using the Korean National Health Insurance Services database. A total of 10 082 568 participants of the 2009 national health screening programme were enrolled. Newly diagnosed Crohn's disease [CD] and ulcerative colitis [UC] were identified using the International Classification of Diseases 10th Revision and specialized national codes for rare intractable diseases. Waist circumference [WC] was classified into six groups and compared with the reference values of 85.0–89.9 cm for men and 80.0–84.9 cm for women. AO was defined as a WC of ≥90 cm for men and ≥85 cm for women. Results During a median follow-up of 9.3 years, the incidence rates of CD and UC were 2.11 and 8.40 per 100 000 person-years, respectively. After adjustment for age, sex, lifestyle behaviours, income and body mass index [BMI], the increase in baseline WC was significantly associated with the risk of developing CD, but not UC, compared to the references. The risk of developing CD in subjects with AO increased significantly compared to those without AO [adjusted hazard ratio, 1.40; 95% confidence interval, 1.21–1.61], regardless of obesity based on BMI. Conclusions Individuals with AO bore an increased risk of developing CD proportional to WC, but not UC, suggesting that visceral adiposity is related to the pathophysiology of CD. [ABSTRACT FROM AUTHOR]

Published
2023
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43. The Common and Unique Pattern of Microbiome Profiles among Saliva, Tissue, and Stool Samples in Patients with Crohn’s Disease

Author

Shin, Seung Yong, primary, Kim, Sounkou, additional, Choi, Ji Won, additional, Kang, Sang-Bum, additional, Kim, Tae Oh, additional, Seo, Geom Seog, additional, Cha, Jae Myung, additional, Chun, Jaeyoung, additional, Jung, Yunho, additional, Im, Jong Pil, additional, Bang, Ki Bae, additional, Choi, Chang Hwan, additional, Park, Soo-Kyung, additional, and Park, Dong Il, additional

Published
2022
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44. Development of a Machine Learning Model to Predict Non-Durable Response to Anti-TNF Therapy in Crohn’s Disease Using Transcriptome Imputed from Genotypes

Author

Park, Soo Kyung, primary, Kim, Yea Bean, additional, Kim, Sangsoo, additional, Lee, Chil Woo, additional, Choi, Chang Hwan, additional, Kang, Sang-Bum, additional, Kim, Tae Oh, additional, Bang, Ki Bae, additional, Chun, Jaeyoung, additional, Cha, Jae Myung, additional, Im, Jong Pil, additional, Kim, Min Suk, additional, Ahn, Kwang Sung, additional, Kim, Seon-Young, additional, and Park, Dong Il, additional

Published
2022
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