Search

Your search keyword '"Chung, Haerim"' showing total 151 results
Start Over Author "Chung, Haerim"
151 results on '"Chung, Haerim"'

8. Clinical outcomes of etoposide and cytarabine as consolidation in elderly patients with primary CNS lymphoma.

Author

Kim, Yu Ri, Cho, Hyunsoo, Kim, Soo-Jeong, Chung, Haerim, Kook, Hye Won, Jang, Ji Eun, Cheong, June-Won, and Kim, Jin Seok

Subjects
FEBRILE neutropenia, RESEARCH funding, TREATMENT effectiveness, RETROSPECTIVE studies, ETOPOSIDE, CYTARABINE, CENTRAL nervous system tumors, THROMBOCYTOPENIA, CONSOLIDATION chemotherapy, PROGRESSION-free survival, OVERALL survival
Abstract

Background A consolidation strategy has not been established for transplant-ineligible elderly patients with primary central nervous system lymphoma (PCNSL). In this study, we aimed to retrospectively evaluate the clinical outcomes of etoposide and cytarabine (EA) as consolidation chemotherapy for transplant-ineligible patients with PCNSL following high-dose methotrexate (MTX)-based induction chemotherapy. Materials and Methods Between 2015 and 2021, newly diagnosed transplant-ineligible patients with PCNSL with diffuse large B-cell lymphoma were consecutively enrolled. All enrolled patients were over 60 years old and received EA consolidation after achieving a complete or partial response following induction chemotherapy. Results Of the 85 patients who achieved a complete or partial response to MTX-based induction chemotherapy, 51 received EA consolidation chemotherapy. Among the 25 (49.0%, 25/51) patients in partial remission before EA consolidation, 56% (n  = 14) achieved complete remission after EA consolidation. The median overall survival and progression-free survival were 43 and 13 months, respectively. Hematological toxicities were most common, and all patients experienced grade 4 neutropenia and thrombocytopenia. Forty-eight patients experienced febrile neutropenia during consolidation chemotherapy, and 4 patients died owing to treatment-related complications. Conclusion EA consolidation chemotherapy for transplant-ineligible, elderly patients with PCNSL improved response rates but showed a high relapse rate and short progression-free survival. The incidences of treatment-related mortality caused by hematologic toxicities and severe infections were very high, even after dose modification. Therefore, the use of EA consolidation should be reconsidered in elderly patients with PCNSL. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

9. 482. Long-Term Outcomes of Coronavirus disease 2019 and Risk Factors for Prolonged SARS-CoV-2 Infection in Lymphoma Patients: Multicenter, Retrospective Cohort Study

Author

Lee, Jung Ah, primary, Han, Min, additional, Ahn, Sangmin, additional, Lee, Yongseop, additional, Yeom, Joon-sup, additional, Choi, Jun Yong, additional, Ku, Nam Su, additional, Jeong, Su Jin, additional, Kim, Jung Ho, additional, Kim, Jin Seok, additional, Chung, Haerim, additional, Cho, Hyunsoo, additional, Kim, Yu Ri, additional, and Ahn, Jin Young, additional

Published
2023
Full Text
View/download PDF

22. Utility of Plasma Microbial Cell-Free DNA Whole-Genome Sequencing for Diagnosis of Invasive Aspergillosis in Patients With Hematologic Malignancy or COVID-19.

Author

Lee, Ki Hyun, Won, Dongju, Kim, Jinnam, Lee, Jung Ah, Kim, Chang Hyup, Kim, Jung Ho, Jeong, Su Jin, Ku, Nam Su, Choi, Jun Yong, Yeom, Joon-Sup, Cho, Hyunsoo, Chung, Haerim, Cheong, June-Won, Lee, Seung-Tae, Jang, Ji Eun, Shin, Saeam, and Ahn, Jin Young

Subjects
CELL-free DNA, NUCLEOTIDE sequencing, HEMATOLOGIC malignancies, DNA sequencing, ASPERGILLOSIS, PULMONARY aspergillosis, CORONAVIRUS diseases
Abstract

Background We evaluated the clinical accuracy and utility of whole-genome sequencing (WGS) of plasma microbial cell-free DNA (cfDNA) as a novel noninvasive method in diagnosing invasive aspergillosis (IA) in patients with hematologic malignancy (HM) or coronavirus disease 2019 (COVID-19). Methods Adults with HM or COVID-19 and suspected IA were recruited. IA cases were retrospectively diagnosed according to EORTC/MSG definitions and ECMM/ISHAM criteria for HM and COVID-19 patients, respectively. The results of cfDNA WGS were compared with the conventional diagnosis. Results Microbial cfDNA WGS was performed 53 times from 41 participants (19 from HM, 16 from COVID-19, and 7 from the control group). In participants with HM, Aspergillus cfDNA was detected in 100% of proven IA and 91.7% of probable IA cases. In participants with COVID-19, 50.0% of probable IA were positive for Aspergillus in cfDNA WGS. Concordance between Aspergillus cfDNA detection and proven/probable IA conventional diagnosis was significantly higher in participants with HM than in those with COVID-19. IA diagnosed using EORTC/MGS definitions showed significantly high concordance between Aspergillus cfDNA detection and proven/probable IA. Conclusions Aspergillus cfDNA detection strongly correlated with proven/probable IA diagnosed using EORTC/MSG definitions and could be used as an additional diagnostic tool for IA. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

24. Ig Gene Clonality Analysis Using Next-Generation Sequencing for Improved Minimal Residual Disease Detection with Significant Prognostic Value in Multiple Myeloma Patients

Author

Ha, Jihye, primary, Lee, Hyeonah, additional, Shin, Saeam, additional, Cho, Hyunsoo, additional, Chung, Haerim, additional, Jang, Ji Eun, additional, Kim, Soo-Jeong, additional, Cheong, June-Won, additional, Lee, Seung-Tae, additional, Kim, Jin Seok, additional, and Choi, Jong Rak, additional

Published
2022
Full Text
View/download PDF

31. Immunosuppressive role of CD11b + CD33 + HLA‐DR − myeloid‐derived suppressor cells‐like blast subpopulation in acute myeloid leukemia

Author

Hyun, Shin Young, primary, Na, Eun Jung, additional, Jang, Ji Eun, additional, Chung, Haerim, additional, Kim, Soo Jeong, additional, Kim, Jin Seok, additional, Kong, Jee Hyun, additional, Shim, Kwang Yong, additional, Lee, Jong In, additional, Min, Yoo Hong, additional, and Cheong, June‐Won, additional

Published
2020
Full Text
View/download PDF

34. YAP and TAZ in Fibroblastic Reticular Cells Support Hematopoiesis and Retention of Lymphocytes in Lymph Nodes

Author

Cho, Hyunsoo, primary, Kim, Yu Ri, additional, Jang, Jieun, additional, Chung, Haerim, additional, Kim, Soo-Jeong, additional, Choi, Sung Yong, additional, Hosung, Bae, additional, Adams, Ralf, additional, Ludewig, Burkhard, additional, Kim, Jin Seok, additional, Cheong, June-Won, additional, Min, Yoo Hong, additional, and Koh, Gou Young, additional

Published
2019
Full Text
View/download PDF

38. Early CMV Replication-Associated Anti-Leukemia Effect Is Related to the Reconstitution of Specific Subsets of Natural Killer Cells after Haploidentical Stem Cell Transplantation in Acute Leukemia

Author

Jang, Jieun, primary, Chung, Haerim, additional, Kim, Yu Ri, additional, Jeung, Hoi-kyung, additional, Eom, Ju-In, additional, Seol, So-Young, additional, Kim, Soo-Jeong, additional, Kim, Jin Seok, additional, Cheong, June-Won, additional, and Min, Yoo Hong, additional

Published
2018
Full Text
View/download PDF

40. HBsAg-Negative, Anti-HBc–Negative Patients Still Have a Risk of Hepatitis B Virus–Related Hepatitis after Autologous Stem Cell Transplantation for Multiple Myeloma or Malignant Lymphoma

Author

Park, Hyunsung, primary, Kim, Do Young, additional, Kim, Soo-Jeong, additional, Chung, Haerim, additional, Cho, Hyunsoo, additional, Jang, Ji Eun, additional, Cheong, June-Won, additional, Min, Yoo Hong, additional, Song, Jae-Woo, additional, and Kim, Jin Seok, additional

Published
2018
Full Text
View/download PDF

42. Immunosuppressive role of CD11b+CD33+HLA‐DR− myeloid‐derived suppressor cells‐like blast subpopulation in acute myeloid leukemia.

Author

Hyun, Shin Young, Na, Eun Jung, Jang, Ji Eun, Chung, Haerim, Kim, Soo Jeong, Kim, Jin Seok, Kong, Jee Hyun, Shim, Kwang Yong, Lee, Jong In, Min, Yoo Hong, and Cheong, June‐Won

Subjects
ACUTE myeloid leukemia, CYTOTOXIC T cells, HEMATOPOIETIC stem cell transplantation, NITRIC-oxide synthases, BONE marrow cells
Abstract

Objective: Myeloid‐derived suppressor cells (MDSCs) facilitate tumor growth and development by suppressing T cell function; however, their role in acute myeloid leukemia (AML) remains unclear. Here, we investigated the immunosuppressive role and prognostic value of blasts with an MDSC‐like phenotype. Methods: CD11b+CD33+HLA‐DR− MDSC‐like blasts from bone marrow mononuclear cells of patients with AML were analyzed. To investigate their T cell‐suppressing function, MDSC‐like blasts were isolated using flow cytometry and co‐cultured with CD8+ cytotoxic T cells and NB4 leukemic cells. Treatment outcomes were then compared between the MDSC‐like blasts low (≤9.76%) and high (>9.76%) groups to identify clinical significance. Results: MDSC‐like blasts showed higher expression of arginase‐1 and inducible nitric oxide synthase. Isolated MDSC‐like blasts significantly suppressed CD8+ T cell proliferation induced by phytohemagglutinin A. NB4 cell proliferation was significantly suppressed upon co‐culture with CD8+ cytotoxic T cells and partially restored upon co‐culture with MDSC‐like blasts. Patients with high MDSC‐like blasts at diagnosis showed substantially shorter overall survival and leukemia‐free survival relative to low MDSC‐like blasts patients, with subgroup analysis showing statistically significant differences in patients not receiving allogeneic hematopoietic stem cell transplantation. Conclusion: We demonstrated that MDSC‐like blasts drive AML‐specific immune‐escape mechanisms by suppressing T cell proliferation and restoring T cell‐suppressed NB4 cell proliferation, with clinically higher fractions of MDSC‐like blasts at diagnosis resulting in poor prognosis. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

48. The Role of MYC and BCL-2 Double Expression the in DLBCL Patients with Advanced Stage and Elevated LDH Who Received Upfront ASCT after R-CHOP

Author

Kim, Yu Ri, primary, Yoon, Sun Och, additional, Kim, Soo-Jeong, additional, Cheong, June-Won, additional, Lee, Hyewon, additional, Chung, Haerim, additional, Lee, Jung Yeon, additional, Jang, Ji Eun, additional, Kim, Yundeok, additional, Yang, Woo-Ick, additional, Min, Yoo-Hong, additional, and Kim, Jin Seok, additional

Published
2016
Full Text
View/download PDF

49. Single-Cell RNA Sequencing Identifies Distinct Immune Microenvironment in Patients with Primary Plasma Cell Leukemia

Author

Cho, Hyunsoo, Chung, Haerim, Kim, Jin Seok, Kim, Mihee, Song, Ga-Young, Ahn, Seo-Yeon, Yang, Deok-Hwan, Kim, Hyeoung-Joon, Lee, Je-Jung, Ahn, Jae-Sook, and Jung, Sung-Hoon

Abstract

Background:Primary plasma cell leukemia (PCL) is a highly aggressive form of multiple myeloma (MM). While recent advances in cellular immunotherapy have significantly improved the outcome of patients with MM, these benefits have been limited for PCL patients, and their survival remains poor. This is in partly attributable to our limited understanding of the dysregulated immune microenvironment in PCL. Furthermore, distinct biological features of PCL compared with MM have not been clearly defined. In this regard, we performed single-cell RNA sequencing of bone marrow (BM) immune cells and tumor cells from patients with MM and PCL at diagnosis and compared them with BM immune cells from healthy donors.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results