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1,513 results on '"Chung, Henry"'

12. Tumor Location Is an Independent Prognostic Factor in Completely Resected Pathological Stage I Non-Small Cell Lung Cancer: A Multicenter Retrospective Study

Author

Wei-Ke Kuo, Po-Ju Chen, Mei-Hsuan Wu, Hsin-Chung (Henry) Lee, Jiun-Kai Fan, Pang-Hung Hsu, and Ching-Fu Weng

Subjects
non-small cell lung cancer, early stage, lower lobe, survival, prognosis, histology, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Previous studies suggested that the location of the primary tumor in non-small cell lung cancer (NSCLC) is associated with clinical features and prognosis, but results are conflicting. The purpose of this study was to explore tumor location as an independent risk factor of survival for patients with completely resected pathological stage I NSCLC. This was a multicenter retrospective study conducted in Taiwan. Included patients were diagnosed with stage I NSCLC and had undergone primary tumor resection. Variables including tumor location, pathological stage, histological differentiation, and International Association for the Study of Lung Cancer (IASLC) grade were evaluated for predictive ability for disease-free survival (DFS) and overall survival (OS). A total of 208 patients were included, with 123 (59.1%) patients having a primary tumor in the upper and middle lobes. The median duration of follow-up for survivors was 60.5 months. Compared to patients with IASLC Grade 3 disease, patients with Grade 1 disease had significantly longer DFS. Tumor location and IASLC grade were independent predictors for OS in multivariate analysis. Specifically, patients with NSCLC in the lower lobe and patients who are histologically classified as IASLC Grade 3 may have poorer prognosis and require greater attention to improve outcomes.

Published
2024
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13. DrosoPhyla: Resources for Drosophilid Phylogeny and Systematics

Author

Finet, Cédric, Kassner, Victoria A, Carvalho, Antonio B, Chung, Henry, Day, Jonathan P, Day, Stephanie, Delaney, Emily K, De Ré, Francine C, Dufour, Héloïse D, Dupim, Eduardo, Izumitani, Hiroyuki F, Gautério, Thaísa B, Justen, Jessa, Katoh, Toru, Kopp, Artyom, Koshikawa, Shigeyuki, Longdon, Ben, Loreto, Elgion L, Nunes, Maria DS, Raja, Komal KB, Rebeiz, Mark, Ritchie, Michael G, Saakyan, Gayane, Sneddon, Tanya, Teramoto, Machiko, Tyukmaeva, Venera, Vanderlinde, Thyago, Wey, Emily E, Werner, Thomas, Williams, Thomas M, Robe, Lizandra J, Toda, Masanori J, and Marlétaz, Ferdinand

Subjects
Biological Sciences, Ecology, Evolutionary Biology, Genetics, Animals, Drosophila, Drosophila melanogaster, Phylogeny, Drosophilidae, phylogenomics, systematics, Biochemistry and Cell Biology, Developmental Biology, Biochemistry and cell biology, Evolutionary biology
Abstract

The vinegar fly Drosophila melanogaster is a pivotal model for invertebrate development, genetics, physiology, neuroscience, and disease. The whole family Drosophilidae, which contains over 4,400 species, offers a plethora of cases for comparative and evolutionary studies. Despite a long history of phylogenetic inference, many relationships remain unresolved among the genera, subgenera, and species groups in the Drosophilidae. To clarify these relationships, we first developed a set of new genomic markers and assembled a multilocus data set of 17 genes from 704 species of Drosophilidae. We then inferred a species tree with highly supported groups for this family. Additionally, we were able to determine the phylogenetic position of some previously unplaced species. These results establish a new framework for investigating the evolution of traits in fruit flies, as well as valuable resources for systematics.

Published
2021

15. Genotypes and phenotypes : implications of exercise on the inter-individual differences in biological responses

Author

Chung, Henry

Abstract

The increase in inactivity and sedentary behaviours has been linked to an increase in people becoming overweight and obese, which leads to serious complications, such as type 2 diabetes, stroke, heart disease, and cancers. Exercise training has been proven to improve the health-related components of fitness, for example endurance, strength, and power and helps tackle these health risks. However, a large proportion of people do not engage in exercise, with a lack of understanding on how to implement exercise efficiently to maximise people's improvements in these components of health-related fitness. Research evidence has shown that exercise genetics play a large role in how people adapt and respond to specific types of exercise training differently. Yet, it is unclear which specific genes are of interest and if this applies to the untrained population, as most research is in elite and well-trained athletes. The aims of this thesis were to first examine the literature-based evidence on the components of health-related fitness responses to different exercise training programmes and the time-courses of these. Secondly, to assemble a list of commonly reported candidate genes and assess the association of these genes to the components of fitness, which has not been done previously. Correlation coefficient showed that training load was significantly associated with the improvements in cardiorespiratory fitness, muscular strength, and anaerobic peak power (R2 = 0.86, 0.50, 0.90, respectively) across 18 studies. Additionally, there were still large inter-individual differences in the improvements of these three phenotypes, even with matched training load and volume. The second review found that certain exercise genes explained up to 72% of this variability. Following these two reviews, training load, habits, and volume were collected via questionnaires in 661 participants from the UK population and compared with the results from the literature review. The findings were then applied in a group of previously untrained participants during a field-based training study. These participants were then genotyped to identify if there were real-world application with exercise training and genetic information to improve health and fitness phenotypes. The results uncovered that training programmes are complex, due to a mixture of training modes, changes in the programme, and progression. Nevertheless, results found that training in endurance improved participants V̇O2max significantly, yet there were still large differences between participants improvements. Eta-squared (η2) found that a large proportion of this was explained by allele-specific genotypes (53.5%), establishing the association between genotypes and the improvements in cardiorespiratory fitness.

Published
2021

20. A New Biological Product Shows Promising Control of the Northern Root-Knot Nematode, Meloidogyne hapla, in Greenhouse Tomatoes

Author

Darling Elisabeth, Palmisano Abigail, Chung Henry, and Quintanilla-Tornel Marisol

Subjects
biological control, management, meloidogyne hapla, nematicides, tomatoes, Biology (General), QH301-705.5
Abstract

Tomato plants are susceptible to significant yield losses when infested by the northern root-knot nematode, Meloidogyne hapla. While there are many options for conventional chemical management, few of these options offer effective control for organic growers or those who seek to adopt more environmentally considerate strategies. In this study, we showed that a new, biologically based product (referred to as “MN21.2”) has potential for controlling populations of the northern root-knot nematode, Meloidogyne hapla, as a pest of susceptible tomato (cv. Rutgers) in a greenhouse trial. This is significant because if this product’s efficacy is supported under field conditions, it may provide organic tomato growers with a valuable tool for fighting the plant-parasitic nematode pest, M. hapla.

Published
2023
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42. BioKG: a comprehensive, high-quality biomedical knowledge graph for AI-powered, data-driven biomedical research

Author

Zhang, Yuan, primary, Pan, Feng, additional, Sui, Xin, additional, Yu, Kaixian, additional, Li, Keqiao, additional, Tian, Shubo, additional, Erdengasileng, Arslan, additional, Han, Qing, additional, Wang, Wanjing, additional, Wang, Jianan, additional, Wang, Jian, additional, Sun, Donghu, additional, Chung, Henry, additional, Zhou, Jun, additional, Zhou, Eric, additional, Lee, Ben, additional, Qiu, Xing, additional, Zhao, Tingting, additional, and Zhang, Jinfeng, additional

Published
2023
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