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673 results on '"Chung, Joon-Yong"'

4. Single-Nucleus RNA Sequencing Reveals Loss of Distal Convoluted Tubule 1 Renal Tubules in HIV Viral Protein R Transgenic Mice

Author

Latt, Khun Zaw, Yoshida, Teruhiko, Shrivastav, Shashi, Abedini, Amin, Reece, Jeff M., Sun, Zeguo, Lee, Hewang, Okamoto, Koji, Dagur, Pradeep, Ishimoto, Yu, Heymann, Jurgen, Zhao, Yongmei, Chung, Joon-Yong, Hewitt, Stephen, Jose, Pedro A., Lee, Kyung, He, John Cijiang, Winkler, Cheryl A., Knepper, Mark A., Kino, Tomoshige, Rosenberg, Avi Z., Susztak, Katalin, and Kopp, Jeffrey B.

Published
2024
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9. Histopathology and SARS-CoV-2 Cellular Localization in Eye Tissues of COVID-19 Autopsies

Author

Stein, Sydney R., Ramelli, Sabrina C., Ramos-Benitez, Marcos J., Platt, Andrew P., Dickey, James M., Curran, Shelly J., Babyak, Ashley L., Valencia, Luis Perez, Richert, Mary E., Vannella, Kevin M., Chertow, Daniel S., Kleiner, David E., Hewitt, Stephen M., Young, Willie J., Young, Sarah P., Gasmi, Billel, De Melo, Michelly Sampaio, Desar, Sabina, Tadros, Saber, Nasir, Nadia, Jin, Xueting, Rajan, Sharika, Dikoglu, Esra, Ozkaya, Neval, Ylaya, Kris, Chung, Joon-Yong, Pittaluga, Stefania, Smith, Grace, Emanuel, Elizabeth R., Kelsall, Brian, Olivera, Justin A., Blawas, Megan, Grazioli, Alison, Hays, Nicole, Purcell, Madeleine, Singireddy, Shreya, Wu, Jocelyn, Raja, Katherine, Curto, Ryan, Chung, Jean, Borth, Amy, Bowers, Kimberly, Weichold, Anne, Minor, Paula, Moshref, Mirahmad, Kelly, Emily, Sajadi, Mohammad M., Scalea, Thomas M., Tran, Douglas, Madathil, Ronson J., Dahi, Siamak, Deatrick, Kristopher B., Krause, Eric M., Rabin, Joseph, Herrold, Joseph A., Tabatabai, Ali, Hochberg, Eric, Cornachione, Christopher, Levine, Andrea R., Saharia, Kapil K., Richards, Justin E., Elder, John, Burke, Allen, Mazzeffi, Michael A., Christenson, Robert, Chancer, Zackary, Abdulmahdi, Mustafa, Sopha, Sabrina, Goldberg, Tyler, Soherwardi, Shahabuddin, Sangwan, Yashvir, McCurdy, Michael T., Sudano, Kristen, Blume, Diane, Radin, Bethany, Arnouk, Madhat, Eagan, James W., Jr., Herr, Daniel L., Zerbe, Christa, Sen, H. Nida, Wang, Yujuan, Kodati, Shilpa, Lee, Jung Wha, Perez, Paola, Singh, Manmeet, Yinda, Kwe Claude, Platt, Andrew, Munster, Vincent J., de Wit, Emmie, Warner, Blake M., and Chan, Chi-Chao

Published
2023
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10. SARS-CoV-2 infection and persistence in the human body and brain at autopsy

Author

Stein, Sydney R., Ramelli, Sabrina C., Grazioli, Alison, Chung, Joon-Yong, Singh, Manmeet, Yinda, Claude Kwe, Winkler, Clayton W., Sun, Junfeng, Dickey, James M., Ylaya, Kris, Ko, Sung Hee, Platt, Andrew P., Burbelo, Peter D., Quezado, Martha, Pittaluga, Stefania, Purcell, Madeleine, Munster, Vincent J., Belinky, Frida, Ramos-Benitez, Marcos J., Boritz, Eli A., Lach, Izabella A., Herr, Daniel L., Rabin, Joseph, Saharia, Kapil K., Madathil, Ronson J., Tabatabai, Ali, Soherwardi, Shahabuddin, McCurdy, Michael T., Peterson, Karin E., Cohen, Jeffrey I., de Wit, Emmie, Vannella, Kevin M., Hewitt, Stephen M., Kleiner, David E., and Chertow, Daniel S.

Published
2022
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18. The interferon-inducible protein viperin controls cancer metabolic reprogramming to enhance cancer progression

Author

Choi, Kyung Mi, Kim, Jeong Jin, Yoo, Jihye, Kim, Ku Sul, Gu, Youngeun, Eom, John, Jeong, Haengdueng, Kim, Kyungeun, Nam, Ki Taek, Park, Young Soo, Chung, Joon-Yong, and Seo, Jun-Young

Subjects
Carcinogenesis -- Genetic aspects, Cell metabolism -- Genetic aspects -- Health aspects, Cellular proteins -- Health aspects, Health care industry
Abstract

Metabolic reprogramming is an important cancer hallmark. However, the mechanisms driving metabolic phenotypes of cancer cells are unclear. Here, we show that the interferon-inducible (IFN-inducible) protein viperin drove metabolic alteration in cancer cells. Viperin expression was observed in various types of cancer and was inversely correlated with the survival rates of patients with gastric, lung, breast, renal, pancreatic, or brain cancer. By generating viperin knockdown or stably expressing cancer cells, we showed that viperin, but not a mutant lacking its iron-sulfur cluster-binding motif, increased lipogenesis and glycolysis via inhibition of fatty acid [beta]-oxidation in cancer cells. In the tumor microenvironment, deficiency of fatty acids and oxygen as well as production of IFNs upregulated viperin expression via the PI3K/AKT/mTOR/HIF-1[alpha] and JAK/STAT pathways. Moreover, viperin was primarily expressed in cancer stem-like cells (CSCs) and functioned to promote metabolic reprogramming and enhance CSC properties, thereby facilitating tumor growth in xenograft mouse models. Collectively, our data indicate that viperin-mediated metabolic alteration drives the metabolic phenotype and progression of cancer., Introduction Cancers are surrounded by a complex microenvironment that causes hypoxic and nutritional stress. Cancer cells reprogram metabolic pathways to support cancer proliferation, growth, metastasis, and survival within this harsh [...]

Published
2022
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34. Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance

Author

Song, Kwon-Ho, Kim, Jae-Hoon, Lee, Young-Ho, Bae, Hyun Cheol, Lee, Hyo-Jung, Woo, Seon Rang, Oh, Se Jin, Lee, Kyung- Mi, Yee, Cassian, Kim, Bo Wook, Cho, Hanbyoul, Chung, Eun Joo, Chung, Joon- Yong, Hewitt, Stephen M., Chung, Tae-Wook, Ha, Ki-Tae, Bae, Young-Ki, Mao, Chih- Ping, Yang, Andrew, Wu, T.C., and Kim, Tae Woo

Subjects
Cancer treatment -- Methods -- Patient outcomes, Gene mutation -- Health aspects, Enzyme regulation -- Health aspects, Drug resistance -- Genetic aspects, Immune response -- Genetic aspects, Health care industry
Abstract

The host immune system plays a pivotal role in the emergence of tumor cells that are refractory to multiple clinical interventions including immunotherapy, chemotherapy, and radiotherapy. Here, we examined the molecular mechanisms by which the immune system triggers cross-resistance to these interventions. By examining the biological changes in murine and tumor cells subjected to sequential rounds of in vitro or in vivo immune selection via cognate cytotoxic T lymphocytes, we found that multimodality resistance arises through a core metabolic reprogramming pathway instigated by epigenetic loss of the ATP synthase subunit ATP5H, which leads to ROS accumulation and HIF-1[alpha] stabilization under normoxia. Furthermore, this pathway confers to tumor cells a stem-like and invasive phenotype. In vivo delivery of antioxidants reverses these phenotypic changes and resensitizes tumor cells to therapy. ATP5H loss in the tumor is strongly linked to failure of therapy, disease progression, and poor survival in patients with cancer. Collectively, our results reveal a mechanism underlying immune-driven multimodality resistance to cancer therapy and demonstrate that rational targeting of mitochondrial metabolic reprogramming in tumor cells may overcome this resistance. We believe these results hold important implications for the clinical management of cancer., Introduction The adaptation of tumor cells to immune surveillance as well as the emergence of refractory tumor cells after initial therapy are responsible for eventual disease relapse, progression, and metastasis. [...]

Published
2018
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38. Data from Downregulation of Filamin A Interacting Protein 1-Like is Associated with Promoter Methylation and Induces an Invasive Phenotype in Ovarian Cancer

Author

Burton, Elizabeth R., primary, Gaffar, Aneesa, primary, Lee, Soo Jin, primary, Adeshuko, Folashade, primary, Whitney, Kathleen D., primary, Chung, Joon-Yong, primary, Hewitt, Stephen M., primary, Huang, Gloria S., primary, Goldberg, Gary L., primary, Libutti, Steven K., primary, and Kwon, Mijung, primary

Published
2023
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39. Supplementary Figure 2 from Downregulation of Filamin A Interacting Protein 1-Like is Associated with Promoter Methylation and Induces an Invasive Phenotype in Ovarian Cancer

Author

Burton, Elizabeth R., primary, Gaffar, Aneesa, primary, Lee, Soo Jin, primary, Adeshuko, Folashade, primary, Whitney, Kathleen D., primary, Chung, Joon-Yong, primary, Hewitt, Stephen M., primary, Huang, Gloria S., primary, Goldberg, Gary L., primary, Libutti, Steven K., primary, and Kwon, Mijung, primary

Published
2023
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40. Supplementary Table 2 from Downregulation of Filamin A Interacting Protein 1-Like is Associated with Promoter Methylation and Induces an Invasive Phenotype in Ovarian Cancer

Author

Burton, Elizabeth R., primary, Gaffar, Aneesa, primary, Lee, Soo Jin, primary, Adeshuko, Folashade, primary, Whitney, Kathleen D., primary, Chung, Joon-Yong, primary, Hewitt, Stephen M., primary, Huang, Gloria S., primary, Goldberg, Gary L., primary, Libutti, Steven K., primary, and Kwon, Mijung, primary

Published
2023
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41. Supplementary Table 1 from Downregulation of Filamin A Interacting Protein 1-Like is Associated with Promoter Methylation and Induces an Invasive Phenotype in Ovarian Cancer

Author

Burton, Elizabeth R., primary, Gaffar, Aneesa, primary, Lee, Soo Jin, primary, Adeshuko, Folashade, primary, Whitney, Kathleen D., primary, Chung, Joon-Yong, primary, Hewitt, Stephen M., primary, Huang, Gloria S., primary, Goldberg, Gary L., primary, Libutti, Steven K., primary, and Kwon, Mijung, primary

Published
2023
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42. Supplementary Figure 3 from Downregulation of Filamin A Interacting Protein 1-Like is Associated with Promoter Methylation and Induces an Invasive Phenotype in Ovarian Cancer

Author

Burton, Elizabeth R., primary, Gaffar, Aneesa, primary, Lee, Soo Jin, primary, Adeshuko, Folashade, primary, Whitney, Kathleen D., primary, Chung, Joon-Yong, primary, Hewitt, Stephen M., primary, Huang, Gloria S., primary, Goldberg, Gary L., primary, Libutti, Steven K., primary, and Kwon, Mijung, primary

Published
2023
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43. Supplementary Figure Legends 1-3 from Downregulation of Filamin A Interacting Protein 1-Like is Associated with Promoter Methylation and Induces an Invasive Phenotype in Ovarian Cancer

Author

Burton, Elizabeth R., primary, Gaffar, Aneesa, primary, Lee, Soo Jin, primary, Adeshuko, Folashade, primary, Whitney, Kathleen D., primary, Chung, Joon-Yong, primary, Hewitt, Stephen M., primary, Huang, Gloria S., primary, Goldberg, Gary L., primary, Libutti, Steven K., primary, and Kwon, Mijung, primary

Published
2023
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44. Supplementary Figure 1 from Downregulation of Filamin A Interacting Protein 1-Like is Associated with Promoter Methylation and Induces an Invasive Phenotype in Ovarian Cancer

Author

Burton, Elizabeth R., primary, Gaffar, Aneesa, primary, Lee, Soo Jin, primary, Adeshuko, Folashade, primary, Whitney, Kathleen D., primary, Chung, Joon-Yong, primary, Hewitt, Stephen M., primary, Huang, Gloria S., primary, Goldberg, Gary L., primary, Libutti, Steven K., primary, and Kwon, Mijung, primary

Published
2023
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45. Supplementary material and method from Targeting Cyclin D-CDK4/6 Sensitizes Immune-Refractory Cancer by Blocking the SCP3–NANOG Axis

Author

Oh, Se Jin, primary, Cho, Hanbyoul, primary, Kim, Suhyun, primary, Noh, Kyung Hee, primary, Song, Kwon-Ho, primary, Lee, Hyo-Jung, primary, Woo, Seon Rang, primary, Kim, Suyeon, primary, Choi, Chel Hun, primary, Chung, Joon-Yong, primary, Hewitt, Stephen M., primary, Kim, Jae-Hoon, primary, Baek, Seungki, primary, Lee, Kyung-Mi, primary, Yee, Cassian, primary, Park, Hae-Chul, primary, and Kim, Tae Woo, primary

Published
2023
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46. Data from Targeting Cyclin D-CDK4/6 Sensitizes Immune-Refractory Cancer by Blocking the SCP3–NANOG Axis

Author

Oh, Se Jin, primary, Cho, Hanbyoul, primary, Kim, Suhyun, primary, Noh, Kyung Hee, primary, Song, Kwon-Ho, primary, Lee, Hyo-Jung, primary, Woo, Seon Rang, primary, Kim, Suyeon, primary, Choi, Chel Hun, primary, Chung, Joon-Yong, primary, Hewitt, Stephen M., primary, Kim, Jae-Hoon, primary, Baek, Seungki, primary, Lee, Kyung-Mi, primary, Yee, Cassian, primary, Park, Hae-Chul, primary, and Kim, Tae Woo, primary

Published
2023
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47. Data from HDAC1 Upregulation by NANOG Promotes Multidrug Resistance and a Stem-like Phenotype in Immune Edited Tumor Cells

Author

Song, Kwon-Ho, primary, Choi, Chel Hun, primary, Lee, Hyo-Jung, primary, Oh, Se Jin, primary, Woo, Seon Rang, primary, Hong, Soon-Oh, primary, Noh, Kyung Hee, primary, Cho, Hanbyoul, primary, Chung, Eun Joo, primary, Kim, Jae-Hoon, primary, Chung, Joon-Yong, primary, Hewitt, Stephen M., primary, Baek, Seungki, primary, Lee, Kyung-Mi, primary, Yee, Cassian, primary, Son, Minjoo, primary, Mao, Chih-Ping, primary, Wu, T.C., primary, and Kim, Tae Woo, primary

Published
2023
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48. Supplementary Figures and Table from Targeting Cyclin D-CDK4/6 Sensitizes Immune-Refractory Cancer by Blocking the SCP3–NANOG Axis

Author

Oh, Se Jin, primary, Cho, Hanbyoul, primary, Kim, Suhyun, primary, Noh, Kyung Hee, primary, Song, Kwon-Ho, primary, Lee, Hyo-Jung, primary, Woo, Seon Rang, primary, Kim, Suyeon, primary, Choi, Chel Hun, primary, Chung, Joon-Yong, primary, Hewitt, Stephen M., primary, Kim, Jae-Hoon, primary, Baek, Seungki, primary, Lee, Kyung-Mi, primary, Yee, Cassian, primary, Park, Hae-Chul, primary, and Kim, Tae Woo, primary

Published
2023
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49. Data from A Novel Quantitative Multiplex Tissue Immunoblotting for Biomarkers Predicts a Prostate Cancer Aggressive Phenotype

Author

Zhu, Guangjing, primary, Liu, Zhi, primary, Epstein, Jonathan I., primary, Davis, Christine, primary, Christudass, Christhunesa S., primary, Carter, H. Ballentine, primary, Landis, Patricia, primary, Zhang, Hui, primary, Chung, Joon-Yong, primary, Hewitt, Stephen M., primary, Miller, M. Craig, primary, and Veltri, Robert W., primary

Published
2023
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50. SUPPLEMENTARY MATERIALS AND METHODS from HDAC1 Upregulation by NANOG Promotes Multidrug Resistance and a Stem-like Phenotype in Immune Edited Tumor Cells

Author

Song, Kwon-Ho, primary, Choi, Chel Hun, primary, Lee, Hyo-Jung, primary, Oh, Se Jin, primary, Woo, Seon Rang, primary, Hong, Soon-Oh, primary, Noh, Kyung Hee, primary, Cho, Hanbyoul, primary, Chung, Eun Joo, primary, Kim, Jae-Hoon, primary, Chung, Joon-Yong, primary, Hewitt, Stephen M., primary, Baek, Seungki, primary, Lee, Kyung-Mi, primary, Yee, Cassian, primary, Son, Minjoo, primary, Mao, Chih-Ping, primary, Wu, T.C., primary, and Kim, Tae Woo, primary

Published
2023
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