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Abstract Rational designing of one-dimensional (1D) magnetic alloy to facilitate electromagnetic (EM) wave attenuation capability in low-frequency (2–6 GHz) microwave absorption field is highly desired but remains a significant challenge. In this study, a composite EM wave absorber made of a FeCoNi medium-entropy alloy embedded in a 1D carbon matrix framework is rationally designed through an improved electrospinning method. The 1D-shaped FeCoNi alloy embedded composite demonstrates the high-density and continuous magnetic network using off-axis electronic holography technique, indicating the excellent magnetic loss ability under an external EM field. Then, the in-depth analysis shows that many factors, including 1D anisotropy and intrinsic physical features of the magnetic medium-entropy alloy, primarily contribute to the enhanced EM wave absorption performance. Therefore, the fabricated EM wave absorber shows an increasing effective absorption band of 1.3 GHz in the low-frequency electromagnetic field at an ultrathin thickness of 2 mm. Thus, this study opens up a new method for the design and preparation of high-performance 1D magnetic EM absorbers.

The effect of mean flow velocity on phosphorus (P) partitioning between water and sediment has received much attention in recent decades. However, the impact of turbulence on the efficiency and capability of sediment adsorbing and desorbing dissolved inorganic phosphorus (DIP) is still unclear. A series of contrasting experiments on the sediment sorption and desorption of DIP with the flow turbulence kinetic energy (TKE) ranging from 1.95 to 2.93 pa have been conducted. It was found that the adsorbed P onto unit mass of sediment increases with the increase in TKE. It is because an increase in TKE results in a rise in the effective adsorption capacity of sediment (bm) by 20–30% during the adsorption process. The bm shows the maximum rise from 0.18 to 0.25 mg/g when TKE increases from 1.95 to 2.93 pa with a fixed sediment concentration of 0.5 g/L. To account for the direct effect of TKE on P adsorption, the Langmuir model is modified by introducing a newly defined coefficient (fA−TKE). The fA−TKE shows a good linear relationship with TKE. Comparison between the modified model and the classic model shows that the amount of adsorbed P could be overestimated by over 50% if the direct effect of turbulence intensity is ignored. The experimental data show that the increase in TKE also enhances the desorption process, with the degree of P desorption (Ddes) increased by 44%. The relation between Ddes and TKE can be well represented using a logarithmic function to quantify the direct effect of turbulence intensity on desorption of P.

A series of laboratory experiments have been conducted to explore the wind effect on Sediment Suspended Concentrations (SSCs) in fine-grained coastal systems. The paddle waves were overplayed with surface-blowing winds in a wind-wave flume to mimic offshore swells coupling with local wind waves during rough weather. Both SSCs and water turbulences under different wind and wave conditions have been investigated over two kinds of sediment beds (Sediment 1, S1, D50 = 52µm and Sediment 2, S2, D50 = 90µm). The High Concentration Layers (HCL) were formed under most of the wave-only conditions, while with the introduction of the stronger wind, more sediment suspensions were transported upward, increasing SSCs in upper water elevations. The finer sediment S1 is easier to suspend than S2 under the same conditions. The enhancement of the vertical turbulence intensity (σw) by winds is the main reason for the increase in SSCs. Meanwhile, because the wind-induced turbulence can hardly penetrate the HCL, the turbulence intensities outside the HCL can be further amplified compared to the experiment without a sediment bed. The wind contributes over 65% of the SSC enlargement above the HCL under a wind of 10m/s for S1, while less than 20% inside the HCL in most wind conditions. The sediment mixing coefficient (ϵs), a crucial parameter for suspended sediment modeling, was enhanced with stronger winds. Although the existing formulas for the vertical distribution of ϵs are valid under both wave-only and small winds (2.5 m/s) for both sediment beds, the enhancement of ϵs caused by strong winds cannot be captured, requiring further research.

PurposeTo compare the clinical outcomes of percutaneous transforaminal endoscopic discectomy (PTED) and unilateral biportal endoscopic discectomy (UBE) for the treatment of single-level lumbar disc herniation (LDH).Materials and methodsFrom January 2020 to November 2021, 62 patients with single-level LDH were retrospectively reviewed. All patients underwent spinal surgeries at the Affiliated Hospital of Chengde Medical University and Beijing Tongren Hospital, Capital Medical University. Among them, 30 patients were treated with UBE, and 32 were treated with PTED. The patients were followed up for at least one year. Patient demographics and perioperative outcomes were reviewed before and after surgery. The Oswestry Disability Index (ODI), visual analog scale (VAS) for back pain and leg pain, and modified MacNab criteria were used to evaluate the clinical outcomes. x-ray examinations were performed one year after surgery to assess the stability of the lumbar spine.ResultsThe mean ages in the UBE and PTED groups were 46.7 years and 48.0 years, respectively. Compared to the UBE group, the PTED group had better VAS scores for back pain at 1 and 7 days after surgery (3.06 ± 0.80 vs. 4.03 ± 0.81, P 0.05). Although the good-to-excellent rate of the modified MacNab criteria in the UBE group was similar to that in the PTED group (86.7% vs. 87.5%, P > 0.05), PTED was advantageous in terms of the operation time, estimated blood loss, incision length, and length of postoperative hospital stay.ConclusionsBoth UBE and PTED have favorable outcomes in patients with single-level LDH. However, PTED is superior to UBE in terms of short-term postoperative back pain relief and perioperative quality of life.

Highlights Benefiting from the possible “seed-germination” effect, the “seeds” Ni2+ grow into “buds” Ni nanoparticles and “stem” carbon nanotubes (CNTs) from the enlarged “soil” of MXene skeleton. Compared with the traditional magnetic agglomeration, the MXene-CNTs/Ni hybrids exhibit the highly spatial dispersed magnetic architecture. 3D MXene-CNTs/Ni composites hold excellent microwave absorption performance (−56.4 dB at only 2.4 mm). Abstract Ti3C2Tx MXene is widely regarded as a potential microwave absorber due to its dielectric multi-layered structure. However, missing magnetic loss capability of pure MXene leads to the unmatched electromagnetic parameters and unsatisfied impedance matching condition. Herein, with the inspiration from dielectric-magnetic synergy, this obstruction is solved by fabricating magnetic CNTs/Ni hetero-structure decorated MXene substrate via a facile in situ induced growth method. Ni2+ ions are successfully attached on the surface and interlamination of each MXene unit by intensive electrostatic adsorption. Benefiting from the possible “seed-germination” effect, the “seeds” Ni2+ grow into “buds” Ni nanoparticles and “stem” carbon nanotubes (CNTs) from the enlarged “soil” of MXene skeleton. Due to the improved impedance matching condition, the MXene-CNTs/Ni hybrid holds a superior microwave absorption performance of − 56.4 dB at only 2.4 mm thickness. Such a distinctive 3D architecture endows the hybrids: (i) a large-scale 3D magnetic coupling network in each dielectric unit that leading to the enhanced magnetic loss capability, (ii) a massive multi-heterojunction interface structure that resulting in the reinforced polarization loss capability, confirmed by the off-axis electron holography. These outstanding results provide novel ideas for developing magnetic MXene-based absorbers.

Abstract Heterointerface engineering is evolving as an effective approach to tune electromagnetic functional materials, but the mechanisms of heterointerfaces on microwave absorption (MA) remain unclear. In this work, abundant electromagnetic heterointerfaces are customized in multilevel hollow architecture via a one‐step synergistic polymerizing‐etching strategy. Fe/Fe3O4@C spindle‐on‐tube structures are transformed from FeOOH@polydopamine precursors by a controllable reduction process. The impressive electromagnetic heterostructures are realized on the Fe/Fe3O4@C hollow spindle arrays and induce strong interfacial polarization. The highly dispersive Fe/Fe3O4 nanoparticles within spindles build multi‐dimension magnetic networks, which enhance the interaction with incident microwaves and reinforce magnetic loss capacity. Moreover, the hierarchically hollow structure and electromagnetic synergistic components are conducive to the impedance matching between absorbing materials and air medium. Furthermore, the mechanisms of electromagnetic heterointerfaces on the MA are systematically investigated. Accordingly, the as‐prepared hierarchical Fe/Fe3O4@C microtubes exhibit remarkable MA performance with a maximum refection loss of −55.4 dB and an absorption bandwidth of 4.2 GHz. Therefore, in this study, the authors not only demonstrate a synergistic strategy to design multilevel hollow architecture, but also provide a fundamental guide in heterointerface engineering of highly efficient electromagnetic functional materials.

Abstract Hierarchical magnetic-dielectric composites are promising functional materials with prospective applications in microwave absorption (MA) field. Herein, a three-dimension hierarchical “nanotubes on microrods,” core–shell magnetic metal–carbon composite is rationally constructed for the first time via a fast metal–organic frameworks-based ligand exchange strategy followed by a carbonization treatment with melamine. Abundant magnetic CoFe nanoparticles are embedded within one-dimensional graphitized carbon/carbon nanotubes supported on micro-scale Mo2N rod (Mo2N@CoFe@C/CNT), constructing a special multi-dimension hierarchical MA material. Ligand exchange reaction is found to determine the formation of hierarchical magnetic-dielectric composite, which is assembled by dielectric Mo2N as core and spatially dispersed CoFe nanoparticles within C/CNTs as shell. Mo2N@CoFe@C/CNT composites exhibit superior MA performance with maximum reflection loss of − 53.5 dB at 2 mm thickness and show a broad effective absorption bandwidth of 5.0 GHz. The Mo2N@CoFe@C/CNT composites hold the following advantages: (1) hierarchical core–shell structure offers plentiful of heterojunction interfaces and triggers interfacial polarization, (2) unique electronic migration/hop paths in the graphitized C/CNTs and Mo2N rod facilitate conductive loss, (3) highly dispersed magnetic CoFe nanoparticles within “tubes on rods” matrix build multi-scale magnetic coupling network and reinforce magnetic response capability, confirmed by the off-axis electron holography.

Immersive Virtual Reality (IVR) is a simulated technology used to deliver multisensory information to people under different environmental conditions. When IVR is generally applied in urban planning and soundscape research, it reveals attractive possibilities for the assessment of urban sound environments with higher immersion for human participation. In virtual sound environments, various topics and measures are designed to collect subjective responses from participants under simulated laboratory conditions. Soundscape or noise assessment studies during virtual experiences adopt an evaluation approach similar to in situ methods. This paper aims to review the approaches that are utilized to assess the ecological validity of IVR for the perception of urban sound environments and the necessary technologies during audio–visual reproduction to establish a dynamic IVR experience that ensures ecological validity. The review shows that, through the use of laboratory tests including subjective response surveys, cognitive performance tests and physiological responses, the ecological validity of IVR can be assessed for the perception of urban sound environments. The reproduction system with head-tracking functions synchronizing spatial audio and visual stimuli (e.g., head-mounted displays (HMDs) with first-order Ambisonics (FOA)-tracked binaural playback) represents the prevailing trend to achieve high ecological validity. These studies potentially contribute to the outcomes of a normalized evaluation framework for subjective soundscape and noise assessments in virtual environments.

Abstract Background The objective of the study was to evaluate our innovative percutaneous endoscopic transforaminal lumbar interbody fusion (PE-TLIF) for the treatment of lumbar degenerative diseases. Methods Two fresh-frozen human cadavers with soft tissues were donated for the experiment. Both cadavers had no history of previous spine surgery. The PE-TLIF surgery was performed on 3 levels (L4-5 of the first one, and L3-4, L4-5 of the second one) in October 2015. The PE-TLIF technique mainly included the following aspects: primary guide pins and a specially designed superior articular process (SAP) guide insertion, working channel setup, endoscopic decompression and fusion, and pedicle screw implantation and fixation. Under the surveillance of C-arm fluoroscope, four primary guide pins were inserted. The inferior primary guide in the hypothetically symptomatic side was confirmed as the first guide pin. At the end of the first guide pin, the specially designed SAP guide was installed. The secondary guide pin was inserted in the SAP via self-designed SAP guide. Under the protection cannula, part of the superior articular process was removed by oriented SAP resection device, so the working channel was smoothly put through the Kambin’s triangle. The endoscope was inserted close to the exiting nerve root. Rotation of the working channel kept the nerve root out of it. Results Three levels of PE-TLIF were successfully performed in two cadavers. Self-designed SAP guide made the secondary guide pin inserting the SAP accurately. Decompression was adequate and the traversing nerve root was relieved. Three aimed intervertebral levels are implanted with two 7-mm-high PEEK cages and one expandable cage. The expandable cage could be adjusted from 8 mm to 13 mm. Surgical incisions included four 15 mm incisions for percutaneous screw fixation and one 12 mm incision for working channel. There was no nerve injury during the operations. Conclusions Our present results showed that the novel minimally invasive surgery PE-TLIF was feasible for the treatment of lumbar degenerative diseases.

The flocculation of cohesive sediments represents a critical process in coastal sediment transport, with its appropriate representation in numerical models crucial for the prediction of contaminant transport, coastal morphodynamics and engineering problems. In this study, a flocculation model considering the effects of multiple fractal dimensions is incorporated into a two-phase numerical modelling framework and used to investigate the effects of spatio-temporal variations in sediment concentrations on the temporal evolution of local floc sizes. Initially, the model is applied to simulate the aggregation of clay suspensions in a vertical grid-stirred settling column, with results confirming the importance of multiple fractal dimensions when predicting the time evolution of floc sizes. The adoption of multiple fractal dimensions, in particular, allows the two-phase numerical model to better match the measured settling column data with improved overall correlation. This is especially the case when predicting initial floc size growth during the early period of settling when the flocs tend to adjust more rapidly to their equilibrium sizes. The two-phase model is then applied to simulate field measurements of mud resuspension process in a tidally driven channel. Again, by considering multiple fractal dimensions within the flocculation model, better agreement is obtained between observed and modelled suspended sediment concentrations, while predicted floc sizes are also in general accord with previous field measurements made within the same estuary.

Jiaozhou Bay (JZB), located at Qingdao City, north China, is a semi-enclosed shallow bay that has undergone large-scale land reclamation and is suffering from a deteriorated water environment. Long-term evolution of JZB with respect of coastline, tidal prism, tidal dynamics, water-exchange capacity, and pollutant transport from 1863 to 2020 was investigated in this paper, using remote sensing images, historical charts, and a numerical model. The JZB was predominated by natural evolution from 1863 to 1935, during which the coastline barely changed. Thereafter, human intervention became intense and more and more natural tidal flats were replaced by salt ponds, aquaculture area, and reclamation very quickly. As a result, tidal prism, area of tidal flats, and area of JZB decreased sharply by 0.290 km3, 182 km2, and 223 km2, respectively, from 1935 to 2020, corresponding to annual decreasing rates being of 123 times, 10 times, 12 times, respectively, as that of before 1935. A numerical model showed that the residual current in JZB tended to be weaker due to the change of coastline and bathymetry, which is not favoring the water-exchange and pollutant transport, especially in the northeast of JZB. The basin residence time increased from 15.5 days in 1935 to 17.6 days in 2020, because of weaker residual tidal current and smaller tidal prism. Local residence time increased significantly near the area with large land reclamation, especially in the northeast and west of JZB. Distribution of dissolved inorganic nitrogen (DIN), in each year, which is the dominant pollutant in JZB, indicated higher DIN concentration and weaker transport along with reclamation. The research on JZB evolution over the last 150 years can provide useful suggestions for the decision-makers of the local government to improve the marine ecosystem. The systematic method to investigate long-term water environment evolution of JZB can be used to study other semi-closed bays.

We aimed to determine factors influencing lymph node metastasis (LNM) and develop a more effective method to assess preoperative N staging. Overall, data of 2130 patients who underwent thyroidectomy for thyroid cancer between 2018 and 2021 were retrospectively analysed. Patients were divided into groups according to pN0, pN1a, and pN1b stages. Pathology was used to analyse the correlation between preoperative serum marker indicators and LNM. Receiver operating characteristic curves were used to compare the diagnostic value of ultrasound (US) examination alone, serum thyroglobulin, age, and combined method for LNM. A significant moderate agreement was observed between preoperative US and postoperative pathology for N staging. Between the pN0 and pN1 (pN1a + pN1b) groups, the differences in free triiodothyronine, anti-thyroid peroxidase antibody, and serum thyroglobulin levels were statistically significant. Among the indicators, serum thyroglobulin was an independent predictor of LNM. The area under the receiver operating characteristic curve was 0.610 for serum thyroglobulin level for predicting LNM, 0.689 for US alone, and 0.742 for the combined method. Both preoperative US and serum thyroglobulin level provide a specific value when evaluating the N staging of thyroid cancer, and the combined method is more valuable in the diagnosis of LNM than US alone.

The driving mechanism of an axisymmetric vectoring exhaust nozzle (AVEN) is a 3-degrees-of-freedom (3-DOF) parallel manipulator (PM) with a centering device. According to the characteristics of the vectoring nozzle’s movement mechanism, the 3-DOF kinematics model of the 3SPS + 3PRS PM is established. The forward and inverse positional posture models are built based on the mechanism architecture of PM and the closed-loop vector method. The Jacobian matrix and Hessian matrix are derived using screw theory, and velocity and acceleration models are established. Based on the principle of virtual work and combined with the kinematics model of PM, a stiffness model was established to analyze stiffness performance. Finally, the effectiveness of the kinematics model of the PM was verified by a simulation, and the variation of stiffness performances with the positional posture of the PM was quantitatively analyzed. The results show that the translational stiffness decreases with forward axial translation of the moving platform and the rotational stiffness is mainly determined by the posture parameters. This study is expected to offer ideas for the kinematic modeling of 3-DOF PM and provide references for application and optimizing of the AVEN’s driving mechanism.

Background: The previously approved botulinum toxin and nowadays promising calcitonin gene-related peptide (CGRP) monoclonal antibody have shown efficacy for preventing chronic migraine (CM). However, there is no direct evidence for their relative effectiveness and safety. In this study, we conducted an indirect treatment comparison to compare the efficacy and safety of CGRP monoclonal antibody with botulinum toxin for the preventive treatment of chronic migraine.Methods: Up to August 31, 2020, we systematically searched PubMed, Embase, and Cochrane Library Central Register of Controlled Trials (Central). Weighted mean difference (WMD) and relative risk (RR) were used to evaluate clinical outcomes. Indirect treatment comparison (ITC) software was used to conduct indirect treatment comparison.Results: Ten studies were pooled with 6,325 patients in our meta-analysis. Both botulinum toxin and CGRP monoclonal antibody demonstrated favorable efficacy in the change of migraine days, headache days, HIT-6 score, and 50% migraine responder rate compared with placebo. In indirect treatment comparison, CGRP monoclonal antibody was superior to botulinum toxin in the frequency of acute analgesics intake (WMD = −1.31, 95% CI: −3.394 to 0.774, p = 0.02113), the rate of treatment-related adverse events (AEs) (RR = 0.664, 95% CI: 0.469 to 0.939, p = 0.04047), and the rate of treatment-related serious adverse events (RR = 0.505, 95% CI: 0.005 to 46.98, p < 0.001).Conclusion: For chronic migraine patients, CGRP monoclonal antibody was slightly better than botulinum toxin in terms of efficacy and safety. In the future, head-to-head trials would be better to evaluate the efficacy and safety between different medications in the prevention of chronic migraine.

Objective This study investigated whether the CYP11B2 -344T/C polymorphism is correlated with transient ischemic attack (TIA) susceptibility. Methods We recruited 100 TIA patients and 100 control subjects and analyzed the CYP11B2 -344T/C polymorphism using restriction fragment length polymorphism (PCR–RFLP). Results The frequency in TIA patients and controls was 42% compared with 48% for TT genotypes, 51% compared with 45% for TC genotypes, and 7% compared with 7% for CC genotype, respectively. Allele frequencies in TIA patients and controls were 67.5% compared with 70.5% for T-allele and 32.5% compared with 29.5% for C-allele, respectively. No association between the CYP11B2 -344T/C polymorphism and TIA was observed in all comparisons. Conclusion Our data suggest that there was no association between the CYP11B2 -344T/C polymorphism and TIA in a Chinese population.

Metabolic changes associated with diabetes are reported to lead to the onset of early-stage diabetic nephropathy (DN). Furthermore, lipotoxicity is implicated in renal dysfunction. Most studies of DN have focused on a single or limited number of lipids, and the lipidome of the kidney during early-stage DN remains to be elucidated. In the present study, we aimed to comprehensively identify lipid abnormalities during early-stage DN; to this end, we established an early-stage DN rat model by feeding a high-sucrose and high-fat diet combined with administration of low-dose streptozotocin. Using a high-coverage, targeted lipidomic approach, we established the lipid profile, comprising 437 lipid species and 25 lipid classes, of the kidney cortex in normal rats and the DN rat model. Our findings additionally confirmed that the DN rat model had been successfully established. We observed distinct lipidomic signatures in the DN kidney, with characteristic alterations in side chain composition and degree of unsaturation. Glyceride lipids, especially cholesteryl esters, showed a significant increase in the DN kidney cortex. The levels of most phospholipids exhibited a decline, except those of phospholipids with side chain of 36:1. Furthermore, the levels of lyso-phospholipids and sphingolipids, including ceramide and its derivatives, were dramatically elevated in the present DN rat model. Our findings, which provide a comprehensive lipidome of the kidney cortex in rats with DN, are expected to be useful for the identification of pathologically relevant lipid species in DN. Furthermore, the results represent novel insights into the mechanistic basis of DN.

In order to study the influence of compliance parts on spatial multibody systems, a rigid-flexible coupling dynamic equation of a spatial crank-slider mechanism is established based on the finite element method. Specifically, absolute node coordinate formulation (ANCF) is used to formulate a three-dimensional, two-node flexible cable element. The rigid-flexible coupling dynamic equation of the mechanism is derived by the Lagrange multiplier method and solved by the generalized α method and Newton–Raphson iteration method combined. Comparison of the kinematics and dynamics response between rigid-flexible coupling system and pure rigid system implies that the flexible part causes a certain degree of nonlinearity and reduces the reaction forces of joints. The elastic modulus of the flexible part is also important to the dynamics of the rigid-flexible multibody system. With smaller elastic modulus, the motion accuracy and reaction forces become lower.

Background: White adipose tissue (WAT) browning confers beneficial effects on metabolic diseases. However, visceral adipose tissue (VAT) is not as susceptible to browning as subcutaneous adipose tissue (SAT). Aim: Interpreting the heterogeneity of VAT and SAT in brown remodeling and provide promising lipid targets to promote WAT browning. Methods: We first investigated the effects of β3-adrenergic stimulation by CL316,243 on systemic metabolism. Then, high-coverage targeted lipidomics approach with multiple reaction monitoring (MRM) was utilized to provide extensive detection of lipid metabolites in VAT and SAT. Results: CL316,243 notably ameliorated the systemic metabolism and induced brown remodeling of SAT but browning resistance of VAT. Comprehensive lipidomics analysis revealed browning heterogeneity of VAT and SAT with more dramatic alteration of lipid classes and species in VAT rather than SAT, though VAT is resistant to browning. Adrenergic stimulation differentially affected glycerides content in VAT and SAT and boosted the abundance of more glycerophospholipids species in VAT than in SAT. Besides, CL316,243 increased sphingolipids in VAT without changes in SAT, meanwhile, elevated cardiolipin species more prominently in VAT than in SAT. Conclusions: We demonstrated the browning heterogeneity of WAT and identified potential lipid biomarkers which may provide lipid targets for overcoming VAT browning resistance.

Background: The lung is one of the primary target organs of hydrogen sulfide (H2S), as exposure to H2S can cause acute lung injury (ALI) and pulmonary edema. Dexamethasone (Dex) exerts a protective effect on ALI caused by exposure to toxic gases and is commonly used in the clinic; however, the underlying mechanisms remain elusive, and the dose is unclear. Methods: In vivo experiments: divided C57BL6 mice into 6 groups at random, 12 in each group. The mice were exposed to H2S for 3 h and 5 or 50 mg/kg Dex pretreated before exposure, sacrificed 12 h later. The morphological changes of HE staining and the ultrastructural changes of lungs under transmission electron microscopy were evaluated. The wet/dry ratio of lung tissue was measured. Bronchial alveolar lavage fluid (BALF) protein content and lung permeability index were detected. The expression of AQP5 protein was measured by immunohistochemistry and Western Blot (WB). In vitro experiments: divided human lung adenocarcinoma cell line A549 into 4 groups. 1 µmol/L dexamethasone was added to pre-incubation. The WB analyzed the protein of p-ERK1/2, p-JNK, and p-p38 in MAPK pathway after 1 h of NaHS exposure; six hours after NaHS exposure, the AQP5 protein was measured by WB. Results: Dex treatment could significantly attenuate the H2S-induced destruction to the alveolar wall, increase the wet-to-dry weight ratio and decrease pulmonary permeability index, with high-dose dexamethasone seemingly functioning better. Additionally, our previous studies showed that aquaporin 5 (AQP 5), a critical protein that regulates water flux, decreased both in a mouse and cell model following the exposure to H2S. This study indicates that tThe decrease in AQP 5 can be alleviated by Dex treatment. Additionally, the mitogen activated protein kinase (MAPK) pathway may be involved in the protective effects of Dex in ALI caused by exposure to H2S since H2Sinduced MAPK activation could be inhibited by Dex. Conclusion: The present results indicate that AQP 5 may be considered a therapeutic target for Dex in H2S or other hazardous gases-induced ALI. [ABSTRACT FROM AUTHOR]