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29 results on '"Chutinimitkul, Salin"'

4. Possible increased pathogenicity of pandemic (H1N1) 2009 influenza virus upon reassortment

Author

Schrauwen, Eefje J.A., Herfst, Sander, Chutinimitkul, Salin, Bestebroer, Theo M., Rimmelzwaan, Guus F., Osterhaus, Albert D.M.E., Kuiken, Thijs, and Fouchier, Ron A.M.

Subjects
Lung diseases -- Development and progression, Influenza viruses, Influenza -- Development and progression, Health
Abstract

The influenza virus A (H1N1) that caused the first influenza pandemic of the 21st century, pandemic (H1N1) 2009, continues to be detected worldwide (1,2). The pandemic overall has been relatively [...]

Published
2011
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7. Fatal Avian influenza a H5N1 in a dog

Author

Songserm, Thaweesak, Amonsin, Alongkorn, Jam-on, Rungroj, Sae-Heng, Namdee, Pariyothorn, Nuananong, Payungporn, Sunchai, Theamboonlers, Apiradee, Chutinimitkul, Salin, Thanawongnuwech, Roongroje, and Poovorawan, Yong

Subjects
Dogs -- Diseases, Dogs -- Health aspects, Avian influenza -- Development and progression, Avian influenza -- Health aspects
Abstract

Avian influenza H5N1 virus is known to cross the species barrier and infect humans and felines. We report a fatal H5N1 infection in a dog following ingestion of an H5N1-infected [...]

Published
2006

12. Assay to detect H5N1 oseltamivir resistance

Author

Suwannakarn, Kamol, Chutinimitkul, Salin, Payungporn, Sunchai, Chieochansin, Thaweesak, Theamboonlers, Apiradee, Amonsin, Alongkorn, Damrongwatanapokin, Sudarat, Mai, Le Quynh, Hanh, Nguyen Hong, and Poovorawan, Yong

Subjects
Influenza -- Care and treatment, Influenza -- Prevention
Abstract

To the Editor: Oseltamivir is a neuraminidase inhibitor approved for treatment and prevention of influenza virus infection. Oseltamivir resistance caused by a single amino acid substitution from histidine (H) to [...]

Published
2006

13. H5N1 influenza A virus and infected human plasma

Author

Chutinimitkul, Salin, Bhattarakosol, Parvapan, Srisuratanon, Surangrat, Eiamudomkan, Atthapon, Kongsomboon, Kittipong, Damrongwatanapokin, Sudarat, Chaisingh, Arunee, Suwannakarn, Kamol, Chieochansin, Thaweesak, Theamboonlers, Apiradee, and Poovorawan, Yong

Abstract

To the Editor: Since January 2004, a total of 22 persons have been confirmed infected with avian influenza A virus (H5N1) in Thailand; 14 of these patients died. Three waves [...]

Published
2006

14. Identification of amino acid substitutions supporting antigenic change of influenza A(H1N1)pdm09 viruses

Author

Koel, Björn F, Mögling, Ramona, Chutinimitkul, Salin, Fraaij, Pieter L, Burke, David F, van der Vliet, Stefan, de Wit, Emmie, Bestebroer, Theo M, Rimmelzwaan, Guus F, Osterhaus, Albert DME, Smith, Derek J, Fouchier, Ron AM, de Graaf, Miranda, Burke, David [0000-0001-8830-3951], Smith, Derek [0000-0002-2393-1890], and Apollo - University of Cambridge Repository

Subjects
DNA Mutational Analysis, Genetic Drift, Ferrets, Hemagglutinin Glycoproteins, Influenza Virus, Antibodies, Viral, Virus Replication, Antibodies, Neutralizing, Antigenic Variation, Influenza A Virus, H1N1 Subtype, Amino Acid Substitution, Animals, Epitopes, B-Lymphocyte, Humans, Antigens, Viral
Abstract

UNLABELLED: The majority of currently circulating influenza A(H1N1) viruses are antigenically similar to the virus that caused the 2009 influenza pandemic. However, antigenic variants are expected to emerge as population immunity increases. Amino acid substitutions in the hemagglutinin protein can result in escape from neutralizing antibodies, affect viral fitness, and change receptor preference. In this study, we constructed mutants with substitutions in the hemagglutinin of A/Netherlands/602/09 in an attenuated backbone to explore amino acid changes that may contribute to emergence of antigenic variants in the human population. Our analysis revealed that single substitutions affecting the loop that consists of amino acid positions 151 to 159 located adjacent to the receptor binding site caused escape from ferret and human antibodies elicited after primary A(H1N1)pdm09 virus infection. The majority of these substitutions resulted in similar or increased replication efficiency in vitro compared to that of the virus carrying the wild-type hemagglutinin and did not result in a change of receptor preference. However, none of the substitutions was sufficient for escape from the antibodies in sera from individuals that experienced both seasonal and pandemic A(H1N1) virus infections. These results suggest that antibodies directed against epitopes on seasonal A(H1N1) viruses contribute to neutralization of A(H1N1)pdm09 antigenic variants, thereby limiting the number of possible substitutions that could lead to escape from population immunity. IMPORTANCE: Influenza A viruses can cause significant morbidity and mortality in humans. Amino acid substitutions in the hemagglutinin protein can result in escape from antibody-mediated neutralization. This allows the virus to reinfect individuals that have acquired immunity to previously circulating strains through infection or vaccination. To date, the vast majority of A(H1N1)pdm09 strains remain antigenically similar to the virus that caused the 2009 influenza pandemic. However, antigenic variants are expected to emerge as a result of increasing population immunity. We show that single amino acid substitutions near the receptor binding site were sufficient to escape from antibodies specific for A(H1N1)pdm09 viruses but not from antibodies elicited in response to infections with seasonal A(H1N1) and A(H1N1)pdm09 viruses. This study identified substitutions in A(H1N1)pdm09 viruses that support escape from population immunity but also suggested that the number of potential escape variants is limited by previous exposure to seasonal A(H1N1) viruses.

Published
2015

15. New strain of influenza A virus (H5N1), Thailand

Author

Chutinimitkul, Salin, Songserm, Thaweesak, Amonsin, Alongkorn, Payungporn, Sunchai, Suwannakarn, Kamol, Damrongwatanapokin, Sudarat, Chaisingh, Arunee, Nuanrichay, Bandit, Chieochansin, Thaweesak, Theamboonlers, Apiradee, and Poovorawan, Yong

Subjects
Avian influenza -- Genetic aspects, Avian influenza -- Research, Molecular systematics -- Research, Public health
Abstract

To the Editor: During 2004-2005, 3 major waves of avian influenza outbreaks occurred in Thailand (1). The first wave was reported in early January 2004, the second in July 2004, [...]

Published
2007

16. Identification of Amino Acid Substitutions Supporting Antigenic Change of Influenza A(H1N1)pdm09 Viruses

Author

Koel, Björn F., primary, Mögling, Ramona, additional, Chutinimitkul, Salin, additional, Fraaij, Pieter L., additional, Burke, David F., additional, van der Vliet, Stefan, additional, de Wit, Emmie, additional, Bestebroer, Theo M., additional, Rimmelzwaan, Guus F., additional, Osterhaus, Albert D. M. E., additional, Smith, Derek J., additional, Fouchier, Ron A. M., additional, and de Graaf, Miranda, additional

Published
2015
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17. Discrimination between highly pathogenic and low pathogenic H5 avian influenza a viruses

Author

Payungporn, Sunchai, Chutinimitkul, Salin, Chaisingh, Arunee, Damrongwantanapokin, Sudarat, Nuansrichay, Bandit, Pinyochon, Wasana, Amonsin, Alongkorn, Donis, Ruben O., Theamboonlers, Apiradee, and Poovorawan, Yong

Abstract

To the Editor: To thoroughly investigate avian influenza outbreaks, identifying highly pathogenic avian influenza (HPAI) and low pathogenic avian influenza (LPAI) is essential. Currently, determination of inserted basic amino acids [...]

Published
2006

19. Virulence-Associated Substitution D222G in the Hemagglutinin of 2009 Pandemic Influenza A(H1N1) Virus Affects Receptor Binding

Author

Chutinimitkul, Salin, primary, Herfst, Sander, additional, Steel, John, additional, Lowen, Anice C., additional, Ye, Jianqiang, additional, van Riel, Debby, additional, Schrauwen, Eefje J. A., additional, Bestebroer, Theo M., additional, Koel, Björn, additional, Burke, David F., additional, Sutherland-Cash, Kyle H., additional, Whittleston, Chris S., additional, Russell, Colin A., additional, Wales, David J., additional, Smith, Derek J., additional, Jonges, Marcel, additional, Meijer, Adam, additional, Koopmans, Marion, additional, Rimmelzwaan, Guus F., additional, Kuiken, Thijs, additional, Osterhaus, Albert D. M. E., additional, García-Sastre, Adolfo, additional, Perez, Daniel R., additional, and Fouchier, Ron A. M., additional

Published
2010
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21. Introduction of Virulence Markers in PB2 of Pandemic Swine-Origin Influenza Virus Does Not Result in Enhanced Virulence or Transmission

Author

Herfst, Sander, primary, Chutinimitkul, Salin, additional, Ye, Jianqiang, additional, de Wit, Emmie, additional, Munster, Vincent J., additional, Schrauwen, Eefje J. A., additional, Bestebroer, Theo M., additional, Jonges, Marcel, additional, Meijer, Adam, additional, Koopmans, Marion, additional, Rimmelzwaan, Guus F., additional, Osterhaus, Albert D. M. E., additional, Perez, Daniel R., additional, and Fouchier, Ron A. M., additional

Published
2010
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24. Detection of Influenza Virus Types A and B and Type A Subtypes (H1, H3, and H5) by Multiplex Polymerase Chain Reaction

Author

Boonsuk, Pitirat, primary, Payungporn, Sunchai, additional, Chieochansin, Thaweesak, additional, Samransamruajkit, Rujipat, additional, Amonsin, Alongkorn, additional, Songserm, Thaweesak, additional, Chaisingh, Arunee, additional, Chamnanpood, Pornchai, additional, Chutinimitkul, Salin, additional, Theamboonlers, Apiradee, additional, and Poovorawan, Yong, additional

Published
2008
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25. The Single-Step Multiplex Reverse Transcription- Polymerase Chain Reaction Assay for Detecting H5 and H7 Avian Influenza A Viruses

Author

Thontiravong, Aunyaratana, primary, Payungporn, Sunchai, additional, Keawcharoen, Juthatip, additional, Chutinimitkul, Salin, additional, Wattanodorn, Sumitra, additional, Damrongwatanapokin, Sudarat, additional, Chaisingh, Arunee, additional, Theamboonlers, Apiradee, additional, Poovorawan, Yong, additional, and Oraveerakul, Kanisak, additional

Published
2007
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26. Genetic characterization of influenza A viruses (H5N1) isolated from 3rd wave of Thailand AI outbreaks

Author

Amonsin, Alongkorn, primary, Chutinimitkul, Salin, additional, Pariyothorn, Nuananong, additional, Songserm, Thaweesak, additional, Damrongwantanapokin, Sudarat, additional, Puranaveja, Suphasawatt, additional, Jam-on, Rungroj, additional, Sae-Heng, Namdee, additional, Payungporn, Sunchai, additional, Theamboonlers, Apiradee, additional, Chaisingh, Arunee, additional, Tantilertcharoen, Rachod, additional, Suradhat, Sanipa, additional, Thanawongnuwech, Roongroje, additional, and Poovorawan, Yong, additional

Published
2006
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29. The spread of avian influenza H5N1 virus; a pandemic threat to mankind.

Author

Chutinimitkul S, Payungporn S, Chieochansin T, Suwannakarn K, Theamboonlers A, and Poovorawan Y

Subjects
Amino Acid Sequence, Animals, Birds, Cats, Communicable Disease Control, Disease Outbreaks, Disease Reservoirs, Disease Transmission, Infectious, Disease Vectors, Global Health, Humans, Influenza Vaccines, Influenza in Birds diagnosis, Influenza in Birds prevention & control, Influenza in Birds transmission, Influenza, Human diagnosis, Influenza, Human prevention & control, Orthomyxoviridae Infections diagnosis, Orthomyxoviridae Infections epidemiology, Orthomyxoviridae Infections prevention & control, Orthomyxoviridae Infections transmission, Phylogeny, Zoonoses, Influenza A Virus, H5N1 Subtype pathogenicity, Influenza in Birds epidemiology, Influenza, Human epidemiology
Abstract

Influenza A H5N1 virus infection presents a major public health problem in Asian and Eurasian countries. The World Health organization has voiced their concerns about a potential pandemic with the imminent threat to humankind. In 1997, an outbreak of highly pathogenic H5N1 virus emerged and caused severe systemic disease among poultry and humans in Hong Kong. This article reviews the magnitude of the 2004-2006 outbreaks in various countries and highlights the highly pathogenic avian influenza (HPAI) subtype H5N1 virus as the cause of a major epidemic with potentially vast repercussions on economics, public health and society at large. Not only has this avian influenza (AI) virus infected poultry but has also proven highly pathogenic and fatal to mammalian species including humans and felines. The present review draws a comprehensive picture encompassing epidemiology, inter-species transmission and genetic characterization of this highly virulent virus. Moreover, laboratory diagnostic techniques, vaccination strategies and antiviral therapies aimed at outbreak control and management are also discussed.

Published
2006

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