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1. Characterizing conical intersections of nucleobases on quantum computers

Author

Wang, Yuchen, Cianci, Cameron, Avdic, Irma, Dutta, Rishab, Warren, Samuel, Allen, Brandon, Vu, Nam P., Santos, Lea F., Batista, Victor S., and Mazziotti, David A.

Subjects
Quantum Physics, Physics - Chemical Physics, Physics - Computational Physics
Abstract

Hybrid quantum-classical computing algorithms offer significant potential for accelerating the calculation of the electronic structure of strongly correlated molecules. In this work, we present the first quantum simulation of conical intersections (CIs) in a biomolecule, cytosine, using a superconducting quantum computer. We apply the Contracted Quantum Eigensolver (CQE) -- with comparisons to conventional Variational Quantum Deflation (VQD) -- to compute the near-degenerate ground and excited states associated with the conical intersection, a key feature governing the photostability of DNA and RNA. The CQE is based on an exact ansatz for many-electron molecules in the absence of noise -- a critically important property for resolving strongly correlated states at CIs. Both methods demonstrate promising accuracy when compared with exact diagonalization, even on noisy intermediate-scale quantum computers, highlighting their potential for advancing the understanding of photochemical and photobiological processes. The ability to simulate these intersections is critical for advancing our knowledge of biological processes like DNA repair and mutation, with potential implications for molecular biology and medical research.

Published
2024

2. Giant light emission enhancement in strain-engineered InSe/MS$_2$ (M=Mo,W) van der Waals heterostructures

Author

Blundo, Elena, Cuccu, Marzia, Tuzi, Federico, Fiorentin, Michele Re, Pettinari, Giorgio, Patra, Atanu, Cianci, Salvatore, Kudrynskyi, Zakhar, Felici, Marco, Taniguchi, Takashi, Watanabe, Kenji, Patanè, Amalia, Palummo, Maurizia, and Polimeni, Antonio

Subjects
Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Two-dimensional crystals stack together through weak van der Waals (vdW) forces, offering unlimited possibilities to play with layer number, order and twist angle in vdW heterostructures (HSs). The realisation of high-performance optoelectronic devices, however, requires the achievement of specific band alignments, $k$-space matching between conduction band minima and valence band maxima, as well as efficient charge transfer between the constituent layers. Fine tuning mechanisms to design ideal HSs are lacking. Here, we show that layer-selective strain engineering can be exploited as an extra degree of freedom in vdW HSs to tailor their band alignment and optical properties. To that end, strain is selectively applied to MS$_2$ (M=Mo,W) monolayers in InSe/MS$_2$ HSs. This triggers a giant PL enhancement of the highly tuneable but weakly emitting InSe by one to three orders of magnitude. Resonant PL excitation measurements, supported by first-principle calculations, provide evidence of a strain-activated direct charge transfer from the MS$_2$ MLs toward InSe. This significant emission enhancement achieved for InSe widens its range of applications for optoelectronics.

Published
2024

3. Hardware-Efficient Fault Tolerant Quantum Computing with Bosonic Grid States in Superconducting Circuits

Author

Lemonde, Marc-Antoine, Lachance-Quirion, Dany, Duclos-Cianci, Guillaume, Frattini, Nicholas E., Hopfmueller, Florian, Gauvin-Ndiaye, Chloe, Camirand-Lemyre, Julien, and St-Jean, Philippe

Subjects
Quantum Physics
Abstract

Quantum computing holds the promise of solving classically intractable problems. Enabling this requires scalable and hardware-efficient quantum processors with vanishing error rates. This perspective manuscript describes how bosonic codes, particularly grid state encodings, offer a pathway to scalable fault-tolerant quantum computing in superconducting circuits. By leveraging the large Hilbert space of bosonic modes, quantum error correction can operate at the single physical unit level, therefore reducing drastically the hardware requirements to bring fault-tolerant quantum computing to scale. Going beyond the well-known Gottesman-Kitaev-Preskill (GKP) code, we discuss how using multiple bosonic modes to encode a single qubit offers increased protection against control errors and enhances its overall error-correcting capabilities. Given recent successful demonstrations of critical components of this architecture, we argue that it offers the shortest path to achieving fault tolerance in gate-based quantum computing processors with a MHz logical clock rate., Comment: This is a perspective paper presenting Nord Quantique's vision towards hardware-efficient FTQC

Published
2024

4. Subspace-Search Quantum Imaginary Time Evolution for Excited State Computations

Author

Cianci, Cameron, Santos, Lea F., and Batista, Victor S.

Subjects
Quantum Physics
Abstract

Quantum systems in excited states are attracting significant interest with the advent of noisy intermediate scale quantum (NISQ) devices. While ground states of small molecular systems are typically explored using hybrid variational algorithms like the variational quantum eigensolver (VQE), the study of excited states has received much less attention, partly due to the absence of efficient algorithms. In this work, we introduce the subspace search quantum imaginary time evolution (SSQITE) method, which calculates excited states using quantum devices by integrating key elements of the subspace search variational quantum eigensolver (SSVQE) and the variational quantum imaginary time evolution (VarQITE) method. The effectiveness of SSQITE is demonstrated through calculations of low-lying excited states of benchmark model systems, including $\text{H}_2$ and $\text{LiH}$ molecules. A toy Hamiltonian is also employed to demonstrate that the robustness of VarQITE in avoiding local minima extends to its use in excited state algorithms. With this robustness in avoiding local minima, SSQITE shows promise for advancing quantum computations of excited states across a wide range of applications., Comment: 21 pages, 6 Figures

Published
2024

5. Hemoperitoneum caused by spontaneous rupture of hepatocellular carcinoma in noncirrhotic liver. A case report and systematic review

Author

Tartaglia Nicola, Di Lascia Alessandra, Cianci Pasquale, Fersini Alberto, Pacilli Mario, Pavone Giovanna, and Ambrosi Antonio

Subjects
hepatocellular carcinoma, hemoperitoneum, noncirrhotic liver, transcatheter arterial embolization, staged hepatectomy, Medicine
Abstract

Hepatocellular carcinoma (HCC) is the sixth most common cancer. Spontaneous rupture of HCC is an acute complication with a high mortality rate. The HCC principally arises in the background of chronic liver disease and cirrhosis of the liver. In the last few years, the rising incidence of HCC in noncirrhotic liver suggests the presence of other factors that may play a role in liver carcinogenesis.

Published
2020
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7. How histopathological diagnosis interacts with kidney ultrasound parameters and glomerular filtration rate

Author

Andrulli, Simeone, Gigante, Antonietta, Rossini, Michele, D’Angio’, Pierluigi, Vischini, Gisella, Luchetta, Franca, Aucella, Filippo, Valsecchi, Giovanni, Infante, Barbara, Vario, Maria Giovanna, Giannese, Domenico, Granata, Antonio, Moggia, Elisabetta, Gembillo, Guido, Cianci, Rosario, Bonomini, Mario, Manenti, Flavia, Lazzarin, Roberta, Renzo, Brigida Di, Zanchelli, Fulvia, Garozzo, Maurizio, Manes, Massimo, Battaglia, Yuri, Sciri, Raffaela, Fabritiis, Marco De, Quaglia, Marco, Cavoli, Gioacchino Li, Gintoli, Enrica, Conte, Maria Maddalena, Borzumati, Maurizio, Benozzi, Luisa, Pasquariello, Giovanna, Andrulli, Giovanni, Leoni, Marco, Seminara, Giuseppe, Corbani, Valentina, Sabiu, Gianmarco, Maggio, Arcangelo Di, Pollastro, Rosa Maria, and Gesualdo, Loreto

Published
2024
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8. Proposal for many-body quantum chaos detection

Author

Das, Adway Kumar, Cianci, Cameron, Cabral, Delmar G. A., Zarate-Herrada, David A., Pinney, Patrick, Pilatowsky-Cameo, Saúl, Matsoukas-Roubeas, Apollonas S., Batista, Victor S., del Campo, Adolfo, Torres-Herrera, E. Jonathan, and Santos, Lea F.

Subjects
Condensed Matter - Statistical Mechanics, Quantum Physics
Abstract

In this work, the term ``quantum chaos'' refers to spectral correlations similar to those found in the random matrix theory. Quantum chaos can be diagnosed through the analysis of level statistics using e.g.~the spectral form factor, which detects both short- and long-range level correlations. The spectral form factor corresponds to the Fourier transform of the two-point spectral correlation function and exhibits a typical slope-dip-ramp-plateau structure (aka correlation hole) when the system is chaotic. We discuss how this structure could be detected through the quench dynamics of two physical quantities accessible to experimental many-body quantum systems: the survival probability and the spin autocorrelation function. The survival probability is equivalent to the spectral form factor with an additional filter. When the system is small, the dip of the correlation hole reaches sufficiently large values at times which are short enough to be detected with current experimental platforms. As the system is pushed away from chaos, the correlation hole disappears, signaling integrability or localization. We also provide a relatively shallow circuit with which the correlation hole could be detected with commercially available quantum computers., Comment: 10 pages, 6 figures

Published
2024

10. Localisation-to-delocalisation transition of moir\'{e} excitons in WSe$_2$/MoSe$_2$ heterostructures

Author

Blundo, Elena, Tuzi, Federico, Cianci, Salvatore, Cuccu, Marzia, Olkowska-Pucko, Katarzyna, Kipczak, Łucja, Contestabile, Giorgio, Miriametro, Antonio, Felici, Marco, Pettinari, Giorgio, Taniguchi, Takashi, Watanabe, Kenji, Babiński, Adam, Molas, Maciej R., and Polimeni, Antonio

Subjects
Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Moir\'{e} excitons (MXs) are electron-hole pairs localised by the periodic (moir\'{e}) potential forming in two-dimensional heterostructures (HSs). MXs can be exploited, $e.g.$, for creating nanoscale-ordered quantum emitters and achieving or probing strongly correlated electronic phases at relatively high temperatures. Here, we studied the exciton properties of a WSe$_2$/MoSe$_2$ HS from $T$=6 K to room temperature using time-resolved and continuous-wave micro-photoluminescence, also under magnetic field. The exciton dynamics and emission lineshape evolution with temperature show clear signatures that MXs de-trap from the moir\'{e} potential and turn into free interlayer excitons (IXs) at $T\gtrsim$120 K. The MX-to-IX transition is also apparent from the exciton magnetic moment reversing its sign when the moir\'{e} potential is not capable to localise excitons at elevated temperatures. Concomitantly, the exciton formation and decay times reduce drastically. Thus, our findings establish the conditions for a truly confined nature of the exciton states in a moir\'{e} superlattice with increasing temperature.

Published
2023

11. Polar form of Dirac fields: implementing symmetries via Lie derivative

Author

Fabbri, Luca, Vignolo, Stefano, and Cianci, Roberto

Subjects
Mathematical Physics
Abstract

We consider the Lie derivative along Killing vector fields of the Dirac relativistic spinors: by using the polar decomposition we acquire the mean to study the implementation of symmetries on Dirac fields. Specifically, we will become able to examine under what conditions it is equivalent to impose a symmetry upon a spinor or only upon its observables. For one physical application, we discuss the role of the above analysis for the specific spherical symmetry, obtaining some no-go theorem regarding spinors and discussing the generality of our approach., Comment: 10 pages

Published
2023
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12. The Quantum-Extended Church-Turing Thesis in Quantum Field Theory

Author

Cianci, Cameron

Subjects
Quantum Physics
Abstract

The quantum-Extended Church-Turing thesis has been explored in many physical theories including general relativity but lacks exploration in quantum field theories such as quantum electrodynamics. Through construction of a computational model whose gate set mimics the interactions of QED, we demonstrate that one of the defining features of quantum field theory, particle creation and annihilation, is not likely to violate the quantum-Extended Church-Turing thesis. Through this computational model, it is shown that particle creation is likely only another form of quantum parallelism. However, whether or not the quantum-Extended Church-Turing thesis will hold for all computational devices in quantum field theories is still not known. For example, we briefly examine certain interactions in quantum electrodynamics which may create multi-qubit gates. These gates may have exponential complexity at the cost of being exponentially weak. This may in turn allow for computational advantage over traditional gate sets such as Clifford+T.

Published
2023

13. Smoothening block rewards: How much should miners pay for mining pools?

Author

Cortes-Cubero, Axel, Madrigal-Cianci, Juan P., Karra, Kiran, and Zhang, Zixuan

Subjects
Computer Science - Cryptography and Security
Abstract

The rewards a blockchain miner earns vary with time. Most of the time is spent mining without receiving any rewards, and only occasionally the miner wins a block and earns a reward. Mining pools smoothen the stochastic flow of rewards, and in the ideal case, provide a steady flow of rewards over time. Smooth block rewards allow miners to choose an optimal mining power growth strategy that will result in a higher reward yield for a given investment. We quantify the economic advantage for a given miner of having smooth rewards, and use this to define a maximum percentage of rewards that a miner should be willing to pay for the mining pool services., Comment: 15 pages, 1 figure

Published
2023

14. The hidden link between late‐onset seizures and cerebral amyloid angiopathy: A case–control study

Author

Oreste Marsico, Angelo Pascarella, Sara Gasparini, Lucia Manzo, Valentina Bova, Vittoria Cianci, Anna Mammì, Domenico Abelardo, Emilio Africa, Giuseppe La Torre, Antonio Armentano, Payam Tabaee Damavandi, Jacopo C. DiFrancesco, Umberto Aguglia, and Edoardo Ferlazzo

Subjects
elderly, epilepsy, gradient echo, hemorrhage, MRI, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Objective Epileptic seizures occurring in late adulthood often remain of unknown origin. Sporadic cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease characterized by intracerebral hemorrhage, microhemorrhage and superficial siderosis, occurring mostly in elderly. This observational case–control study aimed to assess the occurrence of CAA in patients experiencing their first seizure in late adulthood. Methods We enrolled consecutive patients aged ≥55 years presenting with late‐onset seizures (LOS) to the emergency departments or outpatient clinics of two Italian centers, from April 2021 to October 2022. Two age‐matched control subjects with neurological symptoms other than epileptic seizure were recruited for each enrolled case. All participants underwent brain MRI (1.5 Tesla) including blood‐sensitive sequences and were assessed for probable CAA diagnosis according to Boston criteria 2.0. Chi‐squared test was performed to evaluate group differences. Univariate logistic regression analysis tested the association between clinical variables and CAA. Results We included 65 patients with LOS (27 females; mean age 72.2 ± 8.9 years) and 130 controls (49 females; mean age 70.3 ± 8.9 years). Diagnosis of probable CAA was achieved in 10.8% (7/65) of LOS patients and 2.3% (3/130) controls, with a statistically significant difference (p = 0.011). The OR for CAA in the LOS group was 5.2 as compared to the control group (95% CI = 1.3–20.6, p = 0.02). Significance The frequency of CAA is significatively higher in patients with LOS as compared to other neurological diseases, suggesting that a portion of LOS of unknown or vascular origin are associated with CAA. Plain Language Summary Late‐onset seizures (LOS) are very frequent in the elderly and often have no clear cause. Cerebral amyloid angiopathy (CAA) is a condition where amyloid proteins build up in the blood vessels of the brain, causing them to become weak and prone to bleeding. In this study, we explored the occurrence of CAA in people with LOS. We found that people with LOS were more likely to have a diagnosis of CAA than controls (i.e., people with other neurological diseases).

Published
2024
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15. Damage source localisation in complex geometries using acoustic emission and acousto-ultrasonic techniques: an experimental study on clear aligners

Author

Claudia Barile, Claudia Cianci, Vimalathithan Paramsamy Kannan, Giovanni Pappalettera, Carmine Pappalettere, Caterina Casavola, Michele Laurenziello, and Domenico Ciavarella

Subjects
Acoustic emission, Acousto-ultrasonics, Fractographic analysis, Clear dental aligners, Frequency analysis, Time of arrival, Medicine, Science
Abstract

Abstract Passive non-destructive evaluation tools such as acoustic emission (AE) testing and acousto-ultrasonics (AU) approach present a complex problem in damage localisation in complex and nonhomogeneous geometries. A novel AU-guided AE frequency interpretation approach is proposed in this research work which aims at overcoming this limitation. For the experimental evaluation, the damage sources from a geometrically complex clear dental aligners are tested under cyclic compression load and their origins are evaluated. Despite the rapid worldwide diffusion of the clear aligners, their mechanical behaviour is poorly investigated. In this work, the frequency characteristics of the artificially simulated stress wave, generated from different dental positions of the clear aligners, are studied using the AU approach. These frequency characteristics are then used to analyse the AE signals generated by these aligners when subjected to cyclic compressive loading. In addition, the time domain characteristics of the AE signals are studied using their Time of Arrival (ToA). The Akaike Information Criterion (AIC) is used to estimate the ToA. These frequency and time domain characteristics of the AE signals are used to estimate the local damage origin in the clear dental aligners. This will help in identifying localised damage sources during the usage period of the aligners. Experimental results revealed significant damages in the left maxillary premolar and right maxillary third molar of the aligners.

Published
2024
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16. Laparoscopic antegrade cholecystectomy: a standard procedure?

Author

Tartaglia Nicola, Cianci Pasquale, Di Lascia Alessandra, Fersini Alberto, Ambrosi Antonio, and Neri Vincenzo

Subjects
difficult cholecystectomy, laparoscopy, antegrade dissection, cholecystectomy, cholecystitis, fundus first, Medicine
Abstract

Retrograde approach (“fundus first”) is often used in open surgery, while in laparoscopic cholecystectomy (LC) is less frequent. LC, with antegrade access, is done by putting in traction the infundibulum and going up to the fundus before to clip the cystic. Our study analyzes a number of surgical procedures performed by experienced surgeons in laparoscopy.

Published
2016
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17. An Agent-Based Model Framework for Utility-Based Cryptoeconomies

Author

Karra, Kiran, Mellan, Tom, Silva, Maria, Madrigal-Cianci, Juan P., Cortes, Axel Cubero, and Zhang, Zixuan

Subjects
Computer Science - Cryptography and Security
Abstract

In this paper, we outline a framework for modeling utility-based blockchain-enabled economic systems using Agent Based Modeling (ABM). Our approach is to model the supply dynamics based on metrics of the cryptoeconomy. We then build autonomous agents that make decisions based on those metrics. Those decisions, in turn, impact the metrics in the next time-step, creating a closed loop that models the evolution of cryptoeconomies over time. We apply this framework as a case-study to Filecoin, a decentralized blockchain-based storage network. We perform several experiments that explore the effect of different strategies, capitalization, and external factors to agent rewards, that highlight the efficacy of our approach to modeling blockchain based cryptoeconomies., Comment: 14 pages, 5 figures

Published
2023

18. Security of One-Way Entanglement Purification with Quantum Sampling Against a Restricted Adversary

Author

Cianci, Cameron

Subjects
Quantum Physics
Abstract

Entanglement purification protocols promise to play a critical role in the future of quantum networks by distributing entanglement across noisy channels. However, only the security of two-way purification protocols have been closely studied. To address this, we propose a one-way entanglement purification protocol which utilizes quantum sampling and prove its security against an adversary restricted to single qubit Pauli gates. This is done through leveraging the equivalence of one-way entanglement purification protocols with error-correcting codes. To prove the security of this protocol, we first use the quantum sampling framework introduced by Bouman and Fehr to estimate the Hamming weight of the qubits which passed through the channel and then use the estimated relative Hamming weight $\omega$ to determine the amount of interference that Eve has subjected to the quantum channel. Since Eve is restricted to single qubit Pauli gates, the number of applied gates can be directly estimated using the Hamming weight. Estimating the number of adversarial single qubit gates, allows us to perform error correction and disentangle the logical qubit from Eve with probability $1-\epsilon_{qu}^\delta$. Since this protocol allows communication only in one direction, the distance of the code must be decided before transmission, and therefore Bob will be forced to abort the protocol if he finds that Eve has applied more gates than the code can correct. One-way protocols may find use when communication is limited, or when we desire to decrease latency compared to the multiple rounds of communication needed in two-way protocols. Further research may investigate the security of this protocol against arbitrary single or multi-qubit gates to obtain security guarantees against a more general adversary.

Published
2023

19. Potential contribution of GST-T1 and GST-M1 polymorphisms in the onset of hepatic steatosis: from radiological to molecular and medico-legal analyses

Author

Vincenzo Cianci, Cristina Mondello, Gennaro Baldino, Giovanna Spatari, Angela Alibrandi, Alessio Cianci, Annalisa Cracò, Patrizia Gualniera, Alessio Asmundo, Michele Gaeta, Concetto Giorgianni, and Daniela Sapienza

Subjects
steatosis, NAFLD, GSTs, oxidative stress, magnetic resonance imaging, PDFF, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

IntroductionNon-alcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease in the world, and it is characterized by an excessive hepatic fat accumulation in more than 5% of hepatocytes documented by histology in the absence of alcohol consumption. It is a multifactorial pathology, where genetic component plays a fundamental role: the loss-of-function polymorphisms of genes coding for glutathione S-transferases would predispose to the pathology onset, also in the absence of other risk factors. The aim of the study was to evaluate the relation between the “NULL” GST-T1 and GST-M1 polymorphisms and the onset of NAFLD.MethodsA group of 117 “apparently healthy” Caucasian volunteers, selected from a larger population through the analysis of previously administered short questionnaires, underwent both magnetic resonance imaging-proton density fat fraction (MRI-PDFF) and buccal swabs: the aim was to identify the possible presence of hepatic steatosis and of the aforementioned “NULL” polymorphisms of interest.ResultsA statistically significant association between the GST-T1 and GST-M1 “NULL” genotypes and the probability of developing NAFLD has been identified. In particular, the GST-T1 “NULL” genotype has been associated with a greater probability of developing steatosis in early age, while the GST-M1 “NULL” genotype seems to increase the risk of developing a higher grade of steatosis. No statistically significant correlations between the “NULL” genotype and sex have been detected.DiscussionAmong the numerous risk factors capable of predisposing to NAFLD onset and progression, the genetic factors seem to play an important role. In particular, GST-T1 and GST-M1 “NULL” polymorphisms would appear to acquire even greater importance, as their loss of function results in an increase of oxidative stress. At high concentrations, ROS can determine oxidative modifications of cellular macromolecules, such as lipids, determining their accumulation into hepatocytes. The study also highlighted the importance of MRI-PDFF for hepatic steatosis diagnosis: this method allows the acquisition of data comparable to those of conventional biopsy; however, it permits the entire liver parenchyma to be visualized.ConclusionA statistically significant correlation between the presence of GST-T1 and GST-M1 “NULL” genotypes and the presence of hepatic steatosis has been found.

Published
2024
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24. Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago

Author

Perrone, Gennaro, Giuffrida, Mario, Abu-Zidan, Fikri, Kruger, Vitor F., Livrini, Marco, Petracca, Gabriele Luciano, Rossi, Giorgio, Tarasconi, Antonio, Tian, Brian W. C. A., Bonati, Elena, Mentz, Ricardo, Mazzini, Federico N., Campana, Juan P., Gasser, Elisabeth, Kafka-Ritsch, Reinhold, Felsenreich, Daniel M., Dawoud, Christopher, Riss, Stefan, Gomes, Carlos Augusto, Gomes, Felipe Couto, Gonzaga, Ricardo Alessandro Teixeira, Canton, Cassio Alfred Brattig, Pereira, Bruno Monteiro, Fraga, Gustavo P., Zem, Leticia Gonçalves, Cordeiro-Fonseca, Vinicius, de Mesquita Tauil, Renato, Atanasov, Boyko, Belev, Nikolay, Kovachev, Nikola, Meléndez, L. Juan José, Dimova, Ana, Dimov, Stefan, Zelić, Zdravko, Augustin, Goran, Bogdanić, Branko, Morić, Trpimir, Chouillard, Elie, Bajul, Melinda, De Simone, Belinda, Panis, Yves, Esposito, Francesco, Notarnicola, Margherita, Lauka, Lelde, Fabbri, Anna, Hentati, Hassen, Fnaiech, Iskander, Aurélien, Venara, Bougard, Marie, Roulet, Maxime, Demetrashvili, Zaza, Pipia, Irakli, Merabishvili, Giorgi, Bouliaris, Konstantinos, Koukoulis, Georgios, Doudakmanis, Christos, Xenaki, Sofia, Chrysos, Emmanuel, Kokkinakis, Stamatios, Vassiliu, Panteleimon, Michalopoulos, Nikolaos, Margaris, Ioannis, Kechagias, Aristotelis, Avgerinos, Konstantinos, Katunin, Jevgeni, Lostoridis, Eftychios, Nagorni, Eleni-Aikaterini, Pujante, Antonio, Mulita, Francesk, Maroulis, Ioannis, Vailas, Michail, Marinis, Athanasios, Siannis, Ioannis, Bourbouteli, Eirini, Manatakis, Dimitrios K., Tasis, Nikolaos, Acheimastos, Vasileios, Maria, Sotiropoulou, Stylianos, Kapiris, Kuzeridis, Harilaos, Korkolis, Dimitrios, Fradelos, Evangelos, Kavalieratos, George, Petropoulou, Thalia, Polydorou, Andreas, Papacostantinou, Ioannis, Triantafyllou, Tania, Kimpizi, Despina, Theodorou, Dimitrios, Toutouzas, Konstantinos, Chamzin, Alexandros, Frountzas, Maximos, Schizas, Dimitrios, Karavokyros, Ioannis, Syllaios, Athanasios, Charalabopoulos, Alexandros, Boura, Maria, Baili, Efstratia, Ioannidis, Orestis, Loutzidou, Lydia, Anestiadou, Elissavet, Tsouknidas, Ioannis, Petrakis, Georgios, Polenta, Eleni, Bains, Lovenish, Gupta, Rahul, Singh, Sudhir K., Khanduri, Archana, Bala, Miklosh, Kedar, Asaf, Pisano, Marcello, Podda, Mauro, Pisanu, Adolfo, Martines, Gennaro, Trigiante, Giuseppe, Lantone, Giuliano, Agrusa, Antonino, Di Buono, Giuseppe, Buscemi, Salvatore, Veroux, Massimiliano, Gioco, Rossella, Veroux, Gastone, Oragano, Luigi, Zonta, Sandro, Lovisetto, Federico, Feo, Carlo V., Pesce, Antonio, Fabbri, Nicolò, Lantone, Giulio, Marino, Fabio, Perrone, Fabrizio, Vincenti, Leonardo, Papagni, Vincenzo, Picciariello, Arcangelo, Rossi, Stefano, Picardi, Biagio, Del Monte, Simone Rossi, Visconti, Diego, Osella, Giulia, Petruzzelli, Luca, Pignata, Giusto, Andreuccetti, Jacopo, D’Alessio, Rossella, Buonfantino, Massimo, Guaitoli, Eleonora, Spinelli, Stefano, Sampietro, Gianluca Matteo, Corbellini, Carlo, Lorusso, Leonardo, Frontali, Alice, Pezzoli, Isabella, Bonomi, Alessandro, Chierici, Andrea, Cotsoglou, Christian, Manca, Giuseppe, Delvecchio, Antonella, Musa, Nicola, Casati, Massimiliano, Letizia, Laface, Abate, Emmanuele, Ercolani, Giorgio, D’Acapito, Fabrizio, Solaini, Leonardo, Guercioni, Gianluca, Cicconi, Simone, Sasia, Diego, Borghi, Felice, Giraudo, Giorgio, Sena, Giuseppe, Castaldo, Pasquale, Cardamone, Eugenia, Portale, Giuseppe, Zuin, Matteo, Spolverato, Ylenia, Esposito, Marialusia, Isernia, Roberta Maria, Di Salvo, Maria, Manunza, Romina, Esposito, Giuseppe, Agus, Marcello, Asti, Emanuele Luigi Giuseppe, Bernardi, Daniele Tiziano, Tonucci, Tommaso Panici, Luppi, Davide, Casadei, Massimiliano, Bonilauri, Stefano, Pezzolla, Angela, Panebianco, Annunziata, Laforgia, Rita, De Luca, Maurizio, Zese, Monica, Parini, Dario, Jovine, Elio, De Sario, Giuseppina, Lombardi, Raffaele, Aprea, Giovanni, Palomba, Giuseppe, Capuano, Marianna, Argenio, Giulio, Orio, Gianluca, Armellino, Mariano Fortunato, Troian, Marina, Guerra, Martina, Nagliati, Carlo, Biloslavo, Alan, Germani, Paola, Aizza, Giada, Monsellato, Igor, Chahrour, Ali Chaouki, Anania, Gabriele, Bombardini, Cristina, Bagolini, Francesco, Sganga, Gabriele, Fransvea, Pietro, Bianchi, Valentina, Boati, Paolo, Ferrara, Francesco, Palmieri, Francesco, Cianci, Pasquale, Gattulli, Domenico, Restini, Enrico, Cillara, Nicola, Cannavera, Alessandro, Nita, Gabriela Elisa, Sarnari, Jlenia, Roscio, Francesco, Clerici, Federico, Scandroglio, Ildo, Berti, Stefano, Cadeo, Alessandro, Filippelli, Alice, Conti, Luigi, Grassi, Carmine, Cattaneo, Gaetano Maria, Pighin, Marina, Papis, Davide, Gambino, Giovanni, Bertino, Vanessa, Schifano, Domenico, Prando, Daniela, Fogato, Luisella, Cavallo, Fabio, Ansaloni, Luca, Picheo, Roberto, Pontarolo, Nicholas, Depalma, Norma, Spampinato, Marcello, D’Ugo, Stefano, Lepre, Luca, Capponi, Michela Giulii, Campa, Rossella Domenica, Sarro, Giuliano, Dinuzzi, Vincenza Paola, Olmi, Stefano, Uccelli, Matteo, Ferrari, Davide, Inama, Marco, Moretto, Gianluigi, Fontana, Michele, Favi, Francesco, Picariello, Erika, Rampini, Alessia, Barberis, Andrea, Azzinnaro, Antonio, Oliva, Alba, Totaro, Luigi, Benzoni, Ilaria, Ranieri, Valerio, Capolupo, Gabriella Teresa, Carannante, Filippo, Caricato, Marco, Ronconi, Maurizio, Casiraghi, Silvia, Casole, Giovanni, Pantalone, Desire, Alemanno, Giovanni, Scheiterle, Maximilian, Ceresoli, Marco, Cereda, Marco, Fumagalli, Chiara, Zanzi, Federico, Bolzon, Stefano, Guerra, Enrico, Lecchi, Francesca, Cellerino, Paola, Ardito, Antonella, Scaramuzzo, Rosa, Balla, Andrea, Lepiane, Pasquale, Tartaglia, Nicola, Ambrosi, Antonio, Pavone, Giovanna, Palini, Gian Marco, Veneroni, Simone, Garulli, Gianluca, Ricci, Claudio, Torre, Beatrice, Russo, Iris Shari, Rottoli, Matteo, Tanzanu, Marta, Belvedere, Angela, Milone, Marco, Manigrasso, Michele, De Palma, Giovanni Domenico, Piccoli, Micaela, Pattacini, Gianmaria Casoni, Magnone, Stefano, Bertoli, Paolo, Pisano, Michele, Massucco, Paolo, Palisi, Marco, Luzzi, Andrea-Pierre, Fleres, Francesco, Clarizia, Guglielmo, Spolini, Alessandro, Kobe, Yoshiro, Toma, Takayuki, Shimamura, Fumihiko, Parker, Robert, Ranketi, Sinkeet, Mitei, Mercy, Svagzdys, Saulius, Pauzas, Henrikas, Zilinskas, Justas, Poskus, Tomas, Kryzauskas, Marius, Jakubauskas, Matas, Zakaria, Andee Dzulkarnaen, Zakaria, Zaidi, Wong, Michael Pak-Kai, Jusoh, Asri Che, Zakaria, Muhammad Nazreen, Cruz, Daniel Rios, Elizalde, Aurea Barbara Rodriguez, Reynaud, Alejandro Bañon, Hernandez, Edgard Efren Lozada, Monroy, Jose maria Victor Palomo, Hinojosa-Ugarte, Diego, Quiodettis, Martha, Du Bois, María Esther, Latorraca, José, Major, Piotr, Pędziwiatr, Michał, Pisarska-Adamczyk, Magdalena, Walędziak, Maciej, Kwiatkowski, Andrzej, Czyżykowski, Łukasz, da Costa, Silvia Dantas, Pereira, Bela, Ferreira, Ana Rita Oliveira, Almeida, Filipe, Rocha, Ricardo, Carneiro, Carla, Perez, Diego Pita, Carvas, João, Rocha, Catarina, Ferreira, Cátia, Marques, Rita, Fernandes, Urânia, Leao, Pedro, Goulart, André, Pereira, Rita Gonçalves, Patrocínio, Sara Daniela Direito, de Mendonça, Nuno Gonçalo Gonçalves, Manso, Maria Isabel Cerqueira, Morais, Henrique Manuel Cardoso, Cardoso, Paulo Sebastião, Calu, Valentin, Miron, Adrian, Toma, Elena Adelina, Gachabayov, Mahir, Abdullaev, Abakar, Litvin, Andrey, Nechay, Taras, Tyagunov, Alexander, Yuldashev, Anvar, Bradley, Alison, Wilson, Michael, Panyko, Arpád, Látečková, Zuzana, Lacko, Vladimír, Lesko, Dusan, Soltes, Marek, Radonak, Jozef, Turrado-Rodriguez, Victor, Termes-Serra, Roser, Morales-Sevillano, Xavier, Lapolla, Pierfrancesco, Mingoli, Andrea, Brachini, Gioia, Degiuli, Maurizio, Sofia, Silvia, Reddavid, Rossella, de Manzoni Garberini, Andrea, Buffone, Angelica, del Pozo, Eduardo Perea, Aparicio-Sánchez, Daniel, Dos Barbeito, Sandra, Estaire-Gómez, Mercedes, Vitón-Herrero, Rebeca, de los Ángeles Gil Olarte-Marquez, Mª, Gil-Martínez, José, Alconchel, Felipe, Nicolás-López, Tatiana, Rahy-Martin, Aida Cristina, Pelloni, María, Bañolas-Suarez, Raquel, Mendoza-Moreno, Fernando, Nisa, Francisca García-Moreno, Díez-Alonso, Manuel, Rodas, María Elisa Valle, Agundez, María Carmona, Andrés, María Inmaculada Pérez, Moreira, Claudia Cristina Lopes, Perez, Aintzane Lizarazu, Ponce, Iñigo Augusto, González-Castillo, Ana María, Membrilla-Fernández, Estela, Salvans, Silvia, Serradilla-Martín, Mario, Pardo, Pablo Sancho, Rivera-Alonso, Daniel, Dziakova, Jana, Huguet, Jose Mugüerza, Valle, Naila Pagès, Ruiz, Enrique Colás, Valcárcel, Cristina Rey, Moreno, Cristina Ruiz, Salazar, Yeniffer Tatiana Moreno, García, Juan Jesús Rubio, Micó, Silvia Sevila, López, Joaquín Ruiz, Farré, Silvia Pérez, Gomez, Maite Santamaria, Petit, Nuria Mestres, Titos-García, Alberto, Aranda-Narváez, Jose Manuel, Romacho-López, Laura, Sánchez-Guillén, Luis, Aranaz-Ostariz, Veronica, Bosch-Ramírez, Marina, Martínez-Pérez, Aleix, Martínez-López, Elías, Sebastián-Tomás, Juan Carlos, Jimenez-Riera, Granada, Jimenez-Vega, Javier, Cuellar, Jose Aurelio Navas, Campos-Serra, Andrea, Muñoz-Campaña, Anna, Gràcia-Roman, Raquel, Alegre, Javier Martínez, Pinto, Francisca Lima, O’Sullivan, Sara Nuñez, Antona, Francisco Blanco, Jiménez, Beatriz Muñoz, López-Sánchez, Jaime, Carmona, Zahira Gómez, Fernández, Rocio Torres, Sierra, Isabel Blesa, de León, Laura Román García, Moreno, Verónica Polaino, Iglesias, Eva, Cumplido, Paola Lora, Bravo, Altea Arango, Simó, Ignacio Rey, Domínguez, Carlota López, Caamaño, Aloia Guerreiro, Lozano, Rafael Calleja, Martínez, Manuel Durán, Torres, Álvaro Naranjo, de Quiros, Javier Tomas Morales Bernaldo, Pellino, Gianluca, Cloquell, Miriam Moratal, Moller, Elsa García, Jalal-Eldin, Sami, Abdoun, Ahmed K., Hamid, Hytham K. S., Lohsiriwat, Varut, Mongkhonsupphawan, Aitsariya, Baraket, Oussama, Ayed, Karim, Abbassi, Imed, Ali, Ali Ben, Ammar, Houssem, Kchaou, Ali, Tlili, Ahmed, Zribi, Imen, Colak, Elif, Polat, Suleyman, Koylu, Zehra Alan, Guner, Ali, Usta, Mehmet Arif, Reis, Murat Emre, Mantoglu, Baris, Gonullu, Emre, Akin, Emrah, Altintoprak, Fatih, Bayhan, Zulfu, Firat, Necattin, Isik, Arda, Memis, Ufuk, Bayrak, Mehmet, Altıntaş, Yasemin, Kara, Yasin, Bozkurt, Mehmet Abdussamet, Kocataş, Ali, Das, Koray, Seker, Ahmet, Ozer, Nazmi, Atici, Semra Demirli, Tuncer, Korhan, Kaya, Tayfun, Ozkan, Zeynep, Ilhan, Onur, Agackiran, Ibrahim, Uzunoglu, Mustafa Yener, Demirbas, Eren, Altinel, Yuksel, Meric, Serhat, Hacım, Nadir Adnan, Uymaz, Derya Salim, Omarov, Nail, Balık, Emre, Tebala, Giovanni D., Khalil, Hany, Rana, Mridul, Khan, Mansoor, Florence, Charlotte, Swaminathan, Christie, Leo, Cosimo Alex, Liasis, Lampros, Watfah, Josef, Trostchansky, Ivan, Delgado, Edward, Pontillo, Marcelo, Latifi, Rifat, Coimbra, Raul, Edwards, Sara, Lopez, Ana, Velmahos, George, Dorken, Ander, Gebran, Anthony, Palmer, Amanda, Oury, Jeffrey, Bardes, James M., Seng, Sirivan Suon, Coffua, Lauren S., Ratnasekera, Asanthi, Egodage, Tanya, Echeverria-Rosario, Karla, Armento, Isabella, Napolitano, Lena M., Sangji, Naveen F., Hemmila, Mark, Quick, Jacob A., Austin, Tyler R., Hyman, Theodore S., Curtiss, William, McClure, Amanda, Cairl, Nicholas, Biffl, Walter L., Truong, Hung P., Schaffer, Kathryn, Reames, Summer, Banchini, Filippo, Capelli, Patrizio, Coccolini, Federico, Sartelli, Massimo, Bravi, Francesca, Vallicelli, Carlo, Agnoletti, Vanni, Baiocchi, Gian Luca, and Catena, Fausto

Published
2024
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31. Toward Constructing a Continuous Logical Operator for Error-Corrected Quantum Sensing

Author

Cianci, Cameron

Subjects
Quantum Physics
Abstract

Error correction has long been suggested to extend the sensitivity of quantum sensors into the Heisenberg Limit. However, operations on logical qubits are only performed through universal gate sets consisting of finite-sized gates such as Clifford+T. Although these logical gate sets allow for universal quantum computation, the finite gate sizes present a problem for quantum sensing, since in sensing protocols, such as the Ramsey measurement protocol, the signal must act continuously. The difficulty in constructing a continuous logical operator comes from the Eastin-Knill theorem, which prevents a continuous signal from being both fault tolerant to local errors and transverse. Since error correction is needed to approach the Heisenberg Limit in a noisy environment, it is important to explore how to construct fault-tolerant continuous operators. In this paper, a protocol to design continuous logical z-rotations is proposed and applied to the Steane Code. The fault tolerance of the designed operator is investigated using the Knill-Laflamme conditions. The Knill-Laflamme conditions indicate that the diagonal unitary operator constructed cannot be fault tolerant solely due to the possibilities of X errors on the middle qubit. The approach demonstrated throughout this paper may, however, find success in codes with more qubits such as the Shor code, distance 3 surface code, [15,1,3] code, or codes with a larger distance such as the [11,1,5] code.

Published
2023

32. Integrability of Dirac equations in static spherical space-times

Author

Cianci, Roberto, Vignolo, Stefano, and Fabbri, Luca

Subjects
General Relativity and Quantum Cosmology, Mathematical Physics
Abstract

We consider the Dirac equations in static spherically-symmetric space-times, and we present a type of spinor field whose structure allows the separation of elevation angle and radial coordinate in very general situations. We demonstrate that after such a separation of variables the Dirac equations reduce to two equations that can always be integrated, at least in principle. To prove that ours is a fully-working method, we find an explicit exact solution in the special case of the de Sitter universe., Comment: 10 pages

Published
2023
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33. Improvement in diagnostic-therapeutic care pathways for women with migraine: an Italian Delphi panel

Author

Sabina Cevoli, Piero Barbanti, Cinzia Finocchi, Laura Benedan, Paolo Mariani, Nicoletta Orthmann, Salvatore Bauleo, Paola Brusa, Dorella Cianci, Luca Marozio, Sara Masseroni, Roberto Sangermani, Fabio Frediani, and Gianni Allais

Subjects
migraine, woman, Delphi, gynecologist, neurologist, pediatrician, Neurology. Diseases of the nervous system, RC346-429
Abstract

BackgroundMigraine is a highly underestimated and burdensome disease. Real-world studies evidence that migraine is more frequent and severe in women than men. However, to this day, no diagnostic-therapeutic pathways exist to satisfy the specific needs of female patients.MethodsIn this study, migraine experts, specialists in women’s health, patient, and decision makers, analyzed the diagnostic and therapeutic options for women with migraine across various ages and health conditions within the Italian healthcare system. A Delphi approach was used to formulate statements and achieve a consensus.ResultsGaps in clinical practice were identified, and strategies to accommodate women’s needs were proposed. The experts agreed that a socio-behavioral intervention should be planned before any pharmacological treatment in pediatric/adolescent female patients and that the assessment of migraine with aura is considered crucial for adult women requiring contraceptive therapy. Acupuncture emerged as an effective treatment for pregnant and breastfeeding women, and hormone-replacement therapy selection in menopausal patients requires careful consideration to mitigate safety risks. The experts highlighted the absence of literature and guidelines for the management of migraine in women undergoing assisted reproductive procedures or oncological treatment. In light of these observations, the experts advocated the establishment of multidisciplinary collaborations between neurologists/headache specialists and other healthcare professionals, including general practitioners, pediatricians, gynecologists, and oncologists. Comprehensive migraine education for all healthcare professionals potentially involved in managing the disease, including pharmacists, was emphasized. Efforts to increase migraine awareness among women should be prioritized.ConclusionThe insights gained from this Italian consensus study should serve to develop an improved, female-specific pathway to diagnose and treat migraine.

Published
2024
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34. Aortic dissection presenting with respiratory failure: case report and literature

Author

Simone Gherardi, Renato Ippolito, Stefano Pasqualin, Vito Cianci, and Matteo Paganini

Subjects
Aortic dissection, aortic aneurysm, aortic rupture, emergency medicine, Medicine (General), R5-920
Abstract

Due to its nonspecific symptoms, in several cases, Acute Aortic Dissection (AAD) is a difficult-to-diagnose urgent condition. The torn intimal layer initiates a false lumen, which can potentially propagate and cause life-threatening ruptures or organ ischemia. Intramural hematoma can rarely develop inside the false lumen, resulting in compression of surrounding structures and worsening the patient’s prognosis. We report a case of AAD - Stanford Type A complicated by an intramural hematoma compressing the pulmonary artery, accompanied by a discussion of relevant literature. This patient presented to the emergency department with acute respiratory distress; clinical and initial diagnostic findings mimicked pulmonary embolism. However, a systematic differential evaluation supported by point-of-care ultrasound allowed a prompt diagnosis of AAD and avoided fixation errors.

Published
2024
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35. Ergonomics in the operating room and surgical training: a survey on the Italian scenario

Author

Stefano Restaino, Marco D’Indinosante, Federica Perelli, Martina Arcieri, Vittorio Cherchi, Marco Petrillo, Anna Franca Cavaliere, Stefano Cianci, Giulia Pellecchia, Roberto Luca Meniconi, Alessandro Coppola, Vito Chiantera, Giovanni Scambia, Lorenza Driul, Giuseppe Vizzielli, SPIGC Working Group, Berton Federico, Conti Luigi, Formisano Giampaolo, Guaitoli Eleonora, Iossa Angelo, Maruccia Michele, Mazzari Andrea, Oragano Luigi, Pasculli Alessandro, Ratti Francesca, Serenari Matteo, Settembrini Alberto, Sirignano Pasqualino, Soriero Domenico, Vallicelli Carlo, Cianci (Sicilia) Stefano, Iaco (Puglia) Giulia De, Falcone (Campania) Francesca, Giaccari (Triveneto) Sara, Giovenzana (Lombardia) Marco, Pasqui (Toscana) Edoardo, Petrillo (Sardegna) Marco, Portigliotti (Piemonte) Luca, Sena (Calabria) Giuseppe, Sparavigna (Liguria) Marco, Bettini Giordana, Fanello Gianfranco, Mendogni Paolo, Monteleone Lorenzo, Pertile Nicoletta Pia Ardò Davide, Tomaiuolo Pasquina, Negrello Sara, Di Bartolomeo Mattia, Patini Romeo, Vito Marcuzzo Alberto, Campione Alberto, Comacchio Giovanni, Murana Giacomo, Antonio Martino, Manitto Mattia, Galzerano Giuseppe, Di Marco Carlo, Velluti Francesco, Berardi Gianmauro, Romboli Andrea, Weindelmejer Jacopo, Tamburrino Domenico, Calarco Alessandro, Losco Luigi, Nacchiero Eleonora, Elia Rossella, Torto Federico Lo, Vicenti Giovanni, Pappalardo Vincenzo, Pisani Dafne, Palmisano Graziano, Brascia Debora, Troisi Luigi, Renzi Federica, Melandro Fabio, Pecere Silvia, Gazia Carlo, Di Franco Gregorio, Romano Gaetano, Bolletta Alberto, Botteri Emanuele, Di Meo Giovanna, Ronsini Carlo, Chiappetta Sonia, Sgaramella Ilaria, Pennestri Francesco, Girardi Antonella, Mariniello Donatella, Marcasciano Marco, Telegrafo Michele, Fragomeni Simona, Paoli Francesca De, Bogani Giorgio, Gueli Alletti Salvatore, Pedone Anchora Luigi, Della Corte Luigi, Piovano Elisa, Borghese Martina, Taliento Cristina, Raimondo Diego, Raffone Antonio, Casarin Jvan, Perrone Emanuele, Stabile Guglielmo, and Capozzi Vito

Subjects
surgery, ergonomic, gyne and obstetrics, operatory room, survey, Public aspects of medicine, RA1-1270
Abstract

IntroductionSurgical-related injuries are frequent, in fact the reported percentage of musculoskeletal disorders in surgeons is between 47% and 87%. These conditions are caused by long periods of standing, incorrect postures, repeated movements, little rest between operations, the lack of integrated operator rooms, the correct number and arrangement of monitors and the use of non-ergonomic instruments. This survey aims to assess the Italian overview both highlighting how prevalent surgical-related injury is in our surgeons and whether there is an operating room ergonomics education program in Italian surgical specialty schools.MethodsAn anonymous questionnaire was designed through SurveyMonkey© web application. This survey was composed of 3 different sections concerning the general characteristics of the participants, their surgical background and any training performed, and any injuries or ailments related to the surgical activity. The survey was carried out in the period 1th of December 2022 and the 6th of February 2023.ResultsAt the close of our survey, 300 responses were collected. Among the participants, the two most represented specialties were Gynecology and Obstetrics (42.3%) and General Surgery (39.7%) and surgeons were mainly employed in the Northern regions of Italy (54.8%). Analyzing the participants’ background, 61.7% of the respondents had laparoscopic training during their training and only 53.1% had a pelvic trainer during their residency. In accordance with 98.7% of the respondents, during surgery we have the feeling of being in an uncomfortable position that causes discomfort or muscle pain, and regarding the frequency of these discomforts, the majority of our study population experiences these problems monthly (46.2%), while in 29.6% it is experienced weekly, 12.1% annually and finally 12.1% daily. The surgical approach that is most correlated with these disorders is laparoscopy (62.7%) while the one that causes the least discomfort is robotic surgery (1.4%). These discomforts cause 43.9% of our population to take a break or do short exercises to reduce pain during surgery, and the body areas most affected are the back (61.6%), neck (40.6%) and shoulders (37.8%).ConclusionDespite this, our survey allows us to highlight some now-known gaps present in the surgical training program of our schools and the lack of protection toward our surgeons during their long career.

Published
2024
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36. Excitons and trions in WSSe monolayers

Author

Olkowska-Pucko, Katarzyna, Blundo, Elena, Zawadzka, Natalia, Cianci, Salvatore, Vaclavkova, Diana, Kapuściński, Piotr, Jana, Dipankar, Pettinari, Giorgio, Felici, Marco, Nogajewski, Karol, Bartos, Miroslav, Watanabe, Kenji, Taniguchi, Takashi, Faugeras, Clement, Potemski, Marek, Babiński, Adam, Polimeni, Antonio, and Molas, Maciej R.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

The possibility of almost linear tuning of the band gap and of the electrical and optical properties in monolayers (MLs) of semiconducting transition metal dichalcogenide (S-TMD) alloys opens up the way to fabricate materials with on-demand characteristics. By making use of photoluminescence spectroscopy, we investigate optical properties of WSSe MLs with a S/Se ratio of 57/43 deposited on SiO$_2$/Si substrate and encapsulated in hexagonal BN flakes. Similarly to the $"parent"$ WS$_2$ and WSe$_2$ MLs, we assign the WSSe MLs to the ML family with the dark ground exciton state. We find that, in addition to the neutral bright A exciton line, three observed emission lines are associated with negatively charged excitons. The application of in-plane and out-of-plane magnetic fields allows us to assign undeniably the bright and dark (spin- and momentum-forbidden) negative trions as well as the phonon replica of the dark spin-forbidden complex. Furthermore, the existence of the single photon emitters in the WSSe ML is also demonstrated, thus prompting the opportunity to enlarge the wavelength range for potential future quantum applications of S-TMDs., Comment: 6 pages, 5 figures, +ESI

Published
2022
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41. Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago

Author

Gennaro Perrone, Mario Giuffrida, Fikri Abu-Zidan, Vitor F. Kruger, Marco Livrini, Gabriele Luciano Petracca, Giorgio Rossi, Antonio Tarasconi, Brian W. C. A. Tian, Elena Bonati, Ricardo Mentz, Federico N. Mazzini, Juan P. Campana, Elisabeth Gasser, Reinhold Kafka-Ritsch, Daniel M. Felsenreich, Christopher Dawoud, Stefan Riss, Carlos Augusto Gomes, Felipe Couto Gomes, Ricardo Alessandro Teixeira Gonzaga, Cassio Alfred Brattig Canton, Bruno Monteiro Pereira, Gustavo P. Fraga, Leticia Gonçalves Zem, Vinicius Cordeiro-Fonseca, Renato de Mesquita Tauil, Boyko Atanasov, Nikolay Belev, Nikola Kovachev, L. Juan José Meléndez, Ana Dimova, Stefan Dimov, Zdravko Zelić, Goran Augustin, Branko Bogdanić, Trpimir Morić, Elie Chouillard, Melinda Bajul, Belinda De Simone, Yves Panis, Francesco Esposito, Margherita Notarnicola, Lelde Lauka, Anna Fabbri, Hassen Hentati, Iskander Fnaiech, Venara Aurélien, Marie Bougard, Maxime Roulet, Zaza Demetrashvili, Irakli Pipia, Giorgi Merabishvili, Konstantinos Bouliaris, Georgios Koukoulis, Christos Doudakmanis, Sofia Xenaki, Emmanuel Chrysos, Stamatios Kokkinakis, Panteleimon Vassiliu, Nikolaos Michalopoulos, Ioannis Margaris, Aristotelis Kechagias, Konstantinos Avgerinos, Jevgeni Katunin, Eftychios Lostoridis, Eleni-Aikaterini Nagorni, Antonio Pujante, Francesk Mulita, Ioannis Maroulis, Michail Vailas, Athanasios Marinis, Ioannis Siannis, Eirini Bourbouteli, Dimitrios K. Manatakis, Nikolaos Tasis, Vasileios Acheimastos, Sotiropoulou Maria, Kapiris Stylianos, Harilaos Kuzeridis, Dimitrios Korkolis, Evangelos Fradelos, George Kavalieratos, Thalia Petropoulou, Andreas Polydorou, Ioannis Papacostantinou, Tania Triantafyllou, Despina Kimpizi, Dimitrios Theodorou, Konstantinos Toutouzas, Alexandros Chamzin, Maximos Frountzas, Dimitrios Schizas, Ioannis Karavokyros, Athanasios Syllaios, Alexandros Charalabopoulos, Maria Boura, Efstratia Baili, Orestis Ioannidis, Lydia Loutzidou, Elissavet Anestiadou, Ioannis Tsouknidas, Georgios Petrakis, Eleni Polenta, Lovenish Bains, Rahul Gupta, Sudhir K. Singh, Archana Khanduri, Miklosh Bala, Asaf Kedar, Marcello Pisano, Mauro Podda, Adolfo Pisanu, Gennaro Martines, Giuseppe Trigiante, Giuliano Lantone, Antonino Agrusa, Giuseppe Di Buono, Salvatore Buscemi, Massimiliano Veroux, Rossella Gioco, Gastone Veroux, Luigi Oragano, Sandro Zonta, Federico Lovisetto, Carlo V. Feo, Antonio Pesce, Nicolò Fabbri, Giulio Lantone, Fabio Marino, Fabrizio Perrone, Leonardo Vincenti, Vincenzo Papagni, Arcangelo Picciariello, Stefano Rossi, Biagio Picardi, Simone Rossi Del Monte, Diego Visconti, Giulia Osella, Luca Petruzzelli, Giusto Pignata, Jacopo Andreuccetti, Rossella D’Alessio, Massimo Buonfantino, Eleonora Guaitoli, Stefano Spinelli, Gianluca Matteo Sampietro, Carlo Corbellini, Leonardo Lorusso, Alice Frontali, Isabella Pezzoli, Alessandro Bonomi, Andrea Chierici, Christian Cotsoglou, Giuseppe Manca, Antonella Delvecchio, Nicola Musa, Massimiliano Casati, Laface Letizia, Emmanuele Abate, Giorgio Ercolani, Fabrizio D’Acapito, Leonardo Solaini, Gianluca Guercioni, Simone Cicconi, Diego Sasia, Felice Borghi, Giorgio Giraudo, Giuseppe Sena, Pasquale Castaldo, Eugenia Cardamone, Giuseppe Portale, Matteo Zuin, Ylenia Spolverato, Marialusia Esposito, Roberta Maria Isernia, Maria Di Salvo, Romina Manunza, Giuseppe Esposito, Marcello Agus, Emanuele Luigi Giuseppe Asti, Daniele Tiziano Bernardi, Tommaso Panici Tonucci, Davide Luppi, Massimiliano Casadei, Stefano Bonilauri, Angela Pezzolla, Annunziata Panebianco, Rita Laforgia, Maurizio De Luca, Monica Zese, Dario Parini, Elio Jovine, Giuseppina De Sario, Raffaele Lombardi, Giovanni Aprea, Giuseppe Palomba, Marianna Capuano, Giulio Argenio, Gianluca Orio, Mariano Fortunato Armellino, Marina Troian, Martina Guerra, Carlo Nagliati, Alan Biloslavo, Paola Germani, Giada Aizza, Igor Monsellato, Ali Chaouki Chahrour, Gabriele Anania, Cristina Bombardini, Francesco Bagolini, Gabriele Sganga, Pietro Fransvea, Valentina Bianchi, Paolo Boati, Francesco Ferrara, Francesco Palmieri, Pasquale Cianci, Domenico Gattulli, Enrico Restini, Nicola Cillara, Alessandro Cannavera, Gabriela Elisa Nita, Jlenia Sarnari, Francesco Roscio, Federico Clerici, Ildo Scandroglio, Stefano Berti, Alessandro Cadeo, Alice Filippelli, Luigi Conti, Carmine Grassi, Gaetano Maria Cattaneo, Marina Pighin, Davide Papis, Giovanni Gambino, Vanessa Bertino, Domenico Schifano, Daniela Prando, Luisella Fogato, Fabio Cavallo, Luca Ansaloni, Roberto Picheo, Nicholas Pontarolo, Norma Depalma, Marcello Spampinato, Stefano D’Ugo, Luca Lepre, Michela Giulii Capponi, Rossella Domenica Campa, Giuliano Sarro, Vincenza Paola Dinuzzi, Stefano Olmi, Matteo Uccelli, Davide Ferrari, Marco Inama, Gianluigi Moretto, Michele Fontana, Francesco Favi, Erika Picariello, Alessia Rampini, Andrea Barberis, Antonio Azzinnaro, Alba Oliva, Luigi Totaro, Ilaria Benzoni, Valerio Ranieri, Gabriella Teresa Capolupo, Filippo Carannante, Marco Caricato, Maurizio Ronconi, Silvia Casiraghi, Giovanni Casole, Desire Pantalone, Giovanni Alemanno, Maximilian Scheiterle, Marco Ceresoli, Marco Cereda, Chiara Fumagalli, Federico Zanzi, Stefano Bolzon, Enrico Guerra, Francesca Lecchi, Paola Cellerino, Antonella Ardito, Rosa Scaramuzzo, Andrea Balla, Pasquale Lepiane, Nicola Tartaglia, Antonio Ambrosi, Giovanna Pavone, Gian Marco Palini, Simone Veneroni, Gianluca Garulli, Claudio Ricci, Beatrice Torre, Iris Shari Russo, Matteo Rottoli, Marta Tanzanu, Angela Belvedere, Marco Milone, Michele Manigrasso, Giovanni Domenico De Palma, Micaela Piccoli, Gianmaria Casoni Pattacini, Stefano Magnone, Paolo Bertoli, Michele Pisano, Paolo Massucco, Marco Palisi, Andrea-Pierre Luzzi, Francesco Fleres, Guglielmo Clarizia, Alessandro Spolini, Yoshiro Kobe, Takayuki Toma, Fumihiko Shimamura, Robert Parker, Sinkeet Ranketi, Mercy Mitei, Saulius Svagzdys, Henrikas Pauzas, Justas Zilinskas, Tomas Poskus, Marius Kryzauskas, Matas Jakubauskas, Andee Dzulkarnaen Zakaria, Zaidi Zakaria, Michael Pak-Kai Wong, Asri Che Jusoh, Muhammad Nazreen Zakaria, Daniel Rios Cruz, Aurea Barbara Rodriguez Elizalde, Alejandro Bañon Reynaud, Edgard Efren Lozada Hernandez, Jose maria Victor Palomo Monroy, Diego Hinojosa-Ugarte, Martha Quiodettis, María Esther Du Bois, José Latorraca, Piotr Major, Michał Pędziwiatr, Magdalena Pisarska-Adamczyk, Maciej Walędziak, Andrzej Kwiatkowski, Łukasz Czyżykowski, Silvia Dantas da Costa, Bela Pereira, Ana Rita Oliveira Ferreira, Filipe Almeida, Ricardo Rocha, Carla Carneiro, Diego Pita Perez, João Carvas, Catarina Rocha, Cátia Ferreira, Rita Marques, Urânia Fernandes, Pedro Leao, André Goulart, Rita Gonçalves Pereira, Sara Daniela Direito Patrocínio, Nuno Gonçalo Gonçalves de Mendonça, Maria Isabel Cerqueira Manso, Henrique Manuel Cardoso Morais, Paulo Sebastião Cardoso, Valentin Calu, Adrian Miron, Elena Adelina Toma, Mahir Gachabayov, Abakar Abdullaev, Andrey Litvin, Taras Nechay, Alexander Tyagunov, Anvar Yuldashev, Alison Bradley, Michael Wilson, Arpád Panyko, Zuzana Látečková, Vladimír Lacko, Dusan Lesko, Marek Soltes, Jozef Radonak, Victor Turrado-Rodriguez, Roser Termes-Serra, Xavier Morales-Sevillano, Pierfrancesco Lapolla, Andrea Mingoli, Gioia Brachini, Maurizio Degiuli, Silvia Sofia, Rossella Reddavid, Andrea de Manzoni Garberini, Angelica Buffone, Eduardo Perea del Pozo, Daniel Aparicio-Sánchez, Sandra Dos Barbeito, Mercedes Estaire-Gómez, Rebeca Vitón-Herrero, Mª de los Ángeles Gil Olarte-Marquez, José Gil-Martínez, Felipe Alconchel, Tatiana Nicolás-López, Aida Cristina Rahy-Martin, María Pelloni, Raquel Bañolas-Suarez, Fernando Mendoza-Moreno, Francisca García-Moreno Nisa, Manuel Díez-Alonso, María Elisa Valle Rodas, María Carmona Agundez, María Inmaculada Pérez Andrés, Claudia Cristina Lopes Moreira, Aintzane Lizarazu Perez, Iñigo Augusto Ponce, Ana María González-Castillo, Estela Membrilla-Fernández, Silvia Salvans, Mario Serradilla-Martín, Pablo Sancho Pardo, Daniel Rivera-Alonso, Jana Dziakova, Jose Mugüerza Huguet, Naila Pagès Valle, Enrique Colás Ruiz, Cristina Rey Valcárcel, Cristina Ruiz Moreno, Yeniffer Tatiana Moreno Salazar, Juan Jesús Rubio García, Silvia Sevila Micó, Joaquín Ruiz López, Silvia Pérez Farré, Maite Santamaria Gomez, Nuria Mestres Petit, Alberto Titos-García, Jose Manuel Aranda-Narváez, Laura Romacho-López, Luis Sánchez-Guillén, Veronica Aranaz-Ostariz, Marina Bosch-Ramírez, Aleix Martínez-Pérez, Elías Martínez-López, Juan Carlos Sebastián-Tomás, Granada Jimenez-Riera, Javier Jimenez-Vega, Jose Aurelio Navas Cuellar, Andrea Campos-Serra, Anna Muñoz-Campaña, Raquel Gràcia-Roman, Javier Martínez Alegre, Francisca Lima Pinto, Sara Nuñez O’Sullivan, Francisco Blanco Antona, Beatriz Muñoz Jiménez, Jaime López-Sánchez, Zahira Gómez Carmona, Rocio Torres Fernández, Isabel Blesa Sierra, Laura Román García de León, Verónica Polaino Moreno, Eva Iglesias, Paola Lora Cumplido, Altea Arango Bravo, Ignacio Rey Simó, Carlota López Domínguez, Aloia Guerreiro Caamaño, Rafael Calleja Lozano, Manuel Durán Martínez, Álvaro Naranjo Torres, Javier Tomas Morales Bernaldo de Quiros, Gianluca Pellino, Miriam Moratal Cloquell, Elsa García Moller, Sami Jalal-Eldin, Ahmed K. Abdoun, Hytham K. S. Hamid, Varut Lohsiriwat, Aitsariya Mongkhonsupphawan, Oussama Baraket, Karim Ayed, Imed Abbassi, Ali Ben Ali, Houssem Ammar, Ali Kchaou, Ahmed Tlili, Imen Zribi, Elif Colak, Suleyman Polat, Zehra Alan Koylu, Ali Guner, Mehmet Arif Usta, Murat Emre Reis, Baris Mantoglu, Emre Gonullu, Emrah Akin, Fatih Altintoprak, Zulfu Bayhan, Necattin Firat, Arda Isik, Ufuk Memis, Mehmet Bayrak, Yasemin Altıntaş, Yasin Kara, Mehmet Abdussamet Bozkurt, Ali Kocataş, Koray Das, Ahmet Seker, Nazmi Ozer, Semra Demirli Atici, Korhan Tuncer, Tayfun Kaya, Zeynep Ozkan, Onur Ilhan, Ibrahim Agackiran, Mustafa Yener Uzunoglu, Eren Demirbas, Yuksel Altinel, Serhat Meric, Nadir Adnan Hacım, Derya Salim Uymaz, Nail Omarov, Emre Balık, Giovanni D. Tebala, Hany Khalil, Mridul Rana, Mansoor Khan, Charlotte Florence, Christie Swaminathan, Cosimo Alex Leo, Lampros Liasis, Josef Watfah, Ivan Trostchansky, Edward Delgado, Marcelo Pontillo, Rifat Latifi, Raul Coimbra, Sara Edwards, Ana Lopez, George Velmahos, Ander Dorken, Anthony Gebran, Amanda Palmer, Jeffrey Oury, James M. Bardes, Sirivan Suon Seng, Lauren S. Coffua, Asanthi Ratnasekera, Tanya Egodage, Karla Echeverria-Rosario, Isabella Armento, Lena M. Napolitano, Naveen F. Sangji, Mark Hemmila, Jacob A. Quick, Tyler R. Austin, Theodore S. Hyman, William Curtiss, Amanda McClure, Nicholas Cairl, Walter L. Biffl, Hung P. Truong, Kathryn Schaffer, Summer Reames, Filippo Banchini, Patrizio Capelli, Federico Coccolini, Massimo Sartelli, Francesca Bravi, Carlo Vallicelli, Vanni Agnoletti, Gian Luca Baiocchi, and Fausto Catena

Subjects
Hartmann’s procedure, Ostomy, Emergency surgery, Resection, Primary anastomosis, Left side, Surgery, RD1-811, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann’s procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. Methods This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. Results 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P

Published
2024
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42. Minimizing Blood Loss in Laparotomic Myomectomy through the Tourniquet Use: Insights from Our Clinical Experience and Literature Review

Author

Giosuè Giordano Incognito, Ferdinando Antonio Gulino, Stefano Cianci, Sara Occhipinti, Dalila Incognito, Orazio De Tommasi, Fortunato Genovese, and Marco Palumbo

Subjects
uterine myomectomy, laparotomy, surgical blood loss, tourniquets, Surgery, RD1-811
Abstract

The uterine tourniquet is often not used to reduce intraoperative blood loss due to controversial opinions in the literature. The objective was to evaluate the effectiveness of this procedure in laparotomic myomectomy. This is a retrospective, monocentric case-control study, including patients who underwent laparotomic myomectomy and were categorized into the Tourniquet Group (A) and No Tourniquet Group (B). The blood loss outcomes were compared. Intra-operative blood loss in Group A was 275 ± 200 mL, while in Group B was 410 ± 390 mL (p = 0.11). Notably, five patients in the No Tourniquet Group lost more than 1000 mL of blood and required blood transfusion, while no such cases were reported in the Tourniquet Group. Furthermore, the decrease in hemoglobin post-procedure was statistically significant, favoring Group A with a decrease of 1.9 ± 0.7 g/dL compared to Group B’s 2.8 ± 2.2 g/dL (p = 0.04). The use of the Foley catheter as a tourniquet during laparotomic myomectomy may represent a remarkable tool that profoundly impacts the surgical process by substantially reducing blood loss. Its use may play a role in significantly diminishing the likelihood of requiring blood transfusions, enhancing patient safety and outcomes, and should be systematically adopted.

Published
2024
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43. Spectral multiplicity and nodal sets for generic torus-invariant metrics

Author

Cianci, Donato, Judge, Chris, Lin, Samuel, and Sutton, Craig

Subjects
Mathematics - Differential Geometry, Mathematics - Analysis of PDEs, Mathematics - Spectral Theory, 58J50 (Primary) 35P05, 81Q10 (Secondary)
Abstract

Let a torus $T$ act freely on a closed manifold $M$ of dimension at least two. We demonstrate that, for a generic $T$-invariant Riemannian metric $g$ on $M$, each real $\Delta_g$-eigenspace is an irreducible real representation of $T$ and, therefore, has dimension at most two. We also show that, for the generic $T$-invariant metric on $M$, if $u$ is a non-invariant real-valued $\Delta_g$-eigenfunction that vanishes on some $T$-orbit, then the nodal set of $u$ is a connected smooth hypersurface whose complement has exactly two connected components., Comment: 18 pages

Published
2022

44. Finite-rate sparse quantum codes aplenty

Author

Tremblay, Maxime, Duclos-Cianci, Guillaume, and Kourtis, Stefanos

Subjects
Quantum Physics, Computer Science - Artificial Intelligence, Computer Science - Data Structures and Algorithms, Computer Science - Information Theory
Abstract

We introduce a methodology for generating random multi-qubit stabilizer codes based on solving a constraint satisfaction problem (CSP) on random bipartite graphs. This framework allows us to enforce stabilizer commutation, $X/Z$ balancing, finite rate, sparsity, and maximum-degree constraints simultaneously in a CSP that we can then solve numerically. Using a state-of-the-art CSP solver, we obtain convincing evidence for the existence of a satisfiability threshold. Furthermore, the extent of the satisfiable phase increases with the number of qubits. In that phase, finding sparse codes becomes an easy problem. Moreover, we observe that the sparse codes found in the satisfiable phase practically achieve the channel capacity for erasure noise. Our results show that intermediate-size finite-rate sparse quantum codes are easy to find, while also demonstrating a flexible methodology for generating good codes with custom properties. We therefore establish a complete and customizable pipeline for random quantum code discovery.

Published
2022
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45. Unlocking cancer vaccine potential: What are the key factors?

Author

Michael Grant, Lian Ni Lee, Senthil Chinnakannan, Orion Tong, Jonathan Kwok, Nicole Cianci, Luke Tillman, Abhishek Saha, Vinnycius Pereira Almeida, and Carol Leung

Subjects
Cancer vaccine, solid tumors, immunotherapy, cancer antigen, tumor biology, clinical development, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950
Abstract

ABSTRACTCancer is a global health challenge, with changing demographics and lifestyle factors producing an increasing burden worldwide. Screening advancements are enabling earlier diagnoses, but current cancer immunotherapies only induce remission in a small proportion of patients and come at a high cost. Cancer vaccines may offer a solution to these challenges, but they have been mired by poor results in past decades. Greater understanding of tumor biology, coupled with the success of vaccine technologies during the COVID-19 pandemic, has reinvigorated cancer vaccine development. With the first signs of efficacy being reported, cancer vaccines may be beginning to fulfill their potential. Solid tumors, however, present different hurdles than infectious diseases. Combining insights from previous cancer vaccine clinical development and contemporary knowledge of tumor immunology, we ask: who are the ‘right’ patients, what are the ‘right’ targets, and which are the ‘right’ modalities to maximize the chances of cancer vaccine success?

Published
2024
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47. Needle size for thyroid fine needle aspiration cytology. A single institution experience

Author

Pasquale Cianci, Rocco Tumolo, Ivana Conversano, Damiano Travaglia, Giuseppe Trigiante, Giuliano Lantone, Vincenzo Lizzi, Miriam Cappiello, Marco Montagna, Fabio Pio Curci, and Enrico Restini

Subjects
thyroid gland, fine needle aspiration, thyroid nodules, cytology, interventional ultrasonography, Surgery, RD1-811
Abstract

BackgroundFine needle aspiration cytology (FNAC) is an invasive diagnostic technique which is widely used for the cytological diagnosis of thyroid nodules. This procedure is generally widely tolerated by patients, albeit often accompanied by local pain and discomfort. Despite various proposals of execution methods, no approach is universally accepted,especially regarding the size of the needle to be used for sampling. Needle gauge preferences vary across regions, with 25-gauge needles more common in Western countries and 22-gauge needles favored in Asian countries. Complications associated with larger needles have been studied but remain inconclusive.Materials and methodsOver one year, we conducted 300 FNAC procedures under ultrasound guidance, employing both 22-gauge and 25-gauge needles. In no patient was local anesthesia performed before starting the procedure, which in all was performed by the same operator. Similarly the cytological examination of the material taken was performed by a single operator. Patients, 105 males and 195 females, were divided into two groups of 150 each based on the needle size used.ResultsPatients treated with 22-gauge needles reported higher levels of pain during the procedure and increased discomfort afterward. Similarly, a greater incidence of hematomas and vasovagal reactions was noted in this group. However, the cell sample obtained and diagnostic response rates were consistent across both groups.ConclusionOn the basis of our observations we concluded that the size of the needle used is irrelevant for the purposes of the diagnostic result, as long as the procedure is performed by expert personnel. However, the 25-gauge needle is preferable because it's more tolerated and accepted by patients. Our results do not represent a single and conclusive verdict, but they could represent the starting point for further research.

Published
2024
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48. Multicentric data analysis of the learning curve for laparoscopic Shull's repair of pelvic floor defects

Author

S. Cianci, C. Ronsini, G. Riemma, V. Palmara, P. Romeo, M. La Verde, A. S. Laganà, V. Capozzi, G. Andreoli, M. Palumbo, and M. Torella

Subjects
pelvic organs prolapse, laparoscopy, pelvic organ repair, Shull, endoscopy, gynecologic surgery, Surgery, RD1-811
Abstract

IntroductionPelvic organs prolapse remains a significant health concern affecting millions of women worldwide. The use of native tissues to suspend the apex has acquired relevance in urogynecologic surgery. One of the most commonly used procedures performed without mesh is the technique described by Shull, consisting of suturing the vaginal apex to the uterosacral ligaments. The objective of the study is to evaluate the learning curve of laparoscopic Shull's repair for the correction of pelvic floor defects, including the surgery time and surgical outcomes.Materials and methodsThis is a retrospective study conducted at the Policlinico G. Martino, University of Messina, Messina, Italy, and Policlinico Vanvitelli, Vanvitelli University, Naples, Italy. All patients affected by grade I-IV POP, consisting of apical prolapse with or without cystocele, and who underwent laparoscopic Shull's technique for prolapse correction were enrolled. The endpoints to estimate the learning curve for the procedure were the percentage of laparoscopic procedures completed, operative time, and the early complication rate.ResultsA total of 31 laparoscopic Shull repairs were collected for the study. To evaluate the learning curve of the technique, we divided the 31 cases into three different groups: Procedures 0–10; 11–20; 21–31. The parameter for evaluating technique learning was the operative time. Group 21–31 demonstrated an operative time of 97 min (SD 20), compared with 121 min (SD 23) in group 0–10 and 120 min (SD 13) in group 11–20. A comparison of these means through ANOVA showed a p-value of 0.01 for the entire system, and 0.95 for the comparison between 0 and 10 and 11–20, 0.04 for 0–10 vs. 21–31, and 0.02 between 11 and 20 and 21–31.ConclusionsThe rate of surgical improvement in terms of time became effective after an average of 20 procedures. However, the improvement seems to be effective case by case for surgeons skilled in basic endoscopy.

Published
2024
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49. Measurement of neutral current single $\pi^0$ production on argon with the MicroBooNE detector

Author

MicroBooNE collaboration, Abratenko, P., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barnes, C., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Cianci, D., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Aguirre, G. A. Fiorentini, Fitzpatrick, R. S., Fleming, B. T., Foppiani, N., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Kaneshige, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Mettler, T., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Neely, R. K., Newmark, D. A., Nowak, J., Nunes, M., Oza, N., Palamara, O., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Paudel, A., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rice, L. C. J., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Sinclair, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spentzouris, P., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sutton, K., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yarbrough, G., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment
Abstract

We report the first measurement of $\pi^0$ production in neutral current (NC) interactions on argon with average neutrino energy of $\lesssim1$~GeV. We use data from the MicroBooNE detector's 85-tonne active volume liquid argon time projection chamber situated in Fermilab's Booster Neutrino Beam and exposed to $5.89\times10^{20}$ protons on target for this measurement. Measurements of NC $\pi^0$ events are reported for two exclusive event topologies without charged pions. Those include a topology with two photons from the decay of the $\pi^0$ and one proton and a topology with two photons and zero protons. Flux-averaged cross-sections for each exclusive topology and for their semi-inclusive combination are extracted (efficiency-correcting for two-plus proton final states), and the results are compared to predictions from the \textsc{genie}, \textsc{neut}, and \textsc{NuWro} neutrino event generators. We measure cross sections of $1.243\pm0.185$ (syst) $\pm0.076$ (stat), $0.444\pm0.098\pm0.047$, and $0.624\pm0.131\pm0.075$ $[10^{-38}\textrm{cm}^2/\textrm{Ar}]$ for the semi-inclusive NC$\pi^0$, exclusive NC$\pi^0$+1p, and exclusive NC$\pi^0$+0p processes, respectively., Comment: 16 pages, 14 figures, 2 tables

Published
2022

50. Observation of Radon Mitigation in MicroBooNE by a Liquid Argon Filtration System

Author

MicroBooNE collaboration, Abratenko, P., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barnes, C., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Cianci, D., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Aguirre, G. A. Fiorentini, Fitzpatrick, R. S., Fleming, B. T., Foppiani, N., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hilgenberg, C., Horton-Smith, G. A., Hourlier, A., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Joe, C., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Kaneshige, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Mettler, T., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Neely, R. K., Newmark, D. A., Nowak, J., Nunes, M., Palamara, O., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H. B., Pate, S. F., Patel, N., Paudel, A., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rice, L. C. J., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Sinclair, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spentzouris, P., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sutton, K., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yarbrough, G., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., Zhang, C., and Zuckerbrot, M.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The MicroBooNE liquid argon time projection chamber (LArTPC) maintains a high level of liquid argon purity through the use of a filtration system that removes electronegative contaminants in continuously-circulated liquid, recondensed boil off, and externally supplied argon gas. We use the MicroBooNE LArTPC to reconstruct MeV-scale radiological decays. Using this technique we measure the liquid argon filtration system's efficacy at removing radon. This is studied by placing a 500 kBq $^{222}$Rn source upstream of the filters and searching for a time-dependent increase in the number of radiological decays in the LArTPC. In the context of two models for radon mitigation via a liquid argon filtration system, a slowing mechanism and a trapping mechanism, MicroBooNE data supports a radon reduction factor of greater than 99.999% or 97%, respectively. Furthermore, a radiological survey of the filters found that the copper-based filter material was the primary medium that removed the $^{222}$Rn. This is the first observation of radon mitigation in liquid argon with a large-scale copper-based filter and could offer a radon mitigation solution for future large LArTPCs., Comment: 14 pages, 7 figures, accepted by the Journal of Instrumentation

Published
2022
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