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Your search keyword '"Ciaran Byrne"' showing total 3 results
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3 results on '"Ciaran Byrne"'

1. TCT-405 A Novel Machine Learning Algorithm Enhances Prediction of Target Lesion Failure: An Analysis of 4,983 Patients From the XIENCE V USA Database

Author

Divine E. Ediebah, Richard Rapoza, Krishna Sudhir, Jennifer Jones-McMeans, Nick E.J. West, Kusano Hajime, James B. Hermiller, Ciaran Byrne, and Jin Wang

Subjects
Target lesion, business.industry, Medicine, Artificial intelligence, Cardiology and Cardiovascular Medicine, business, Machine learning, computer.software_genre, computer
Published
2021
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3. Synthesis of Filibuvir. Part I. Diastereoselective Preparation of a β-Hydroxy Alkynyl Oxazolidinone and Conversion to a 6,6-Disubstituted 2H-Pyranone

Author

Maria M. O’Sullivan, Eric M. Cordi, Jon Blunt, Gregory W. Sluggett, Ciaran Byrne, John A. Ragan, Brian G. Conway, Corey L. Stanchina, Sandra Mullane, Esmort Chisowa, Stuart Taylor, Janice E. Sieser, Denis Lynch, Leo Joseph Letendre, Marcella Whelan, Holly Strohmeyer, Robert A. Singer, Paul Bowles, and Kyle R. Leeman

Subjects
chemistry.chemical_classification, Ketone, Stereochemistry, Organic Chemistry, Sonogashira coupling, Alcohol, Stereocenter, Acylation, chemistry.chemical_compound, chemistry, Aldol reaction, Electrophile, Physical and Theoretical Chemistry, Lactone
Abstract

This is the first in a series of three papers describing the identification and development of a commercial synthesis of filibuvir (1). This contribution describes development of an Evans aldol reaction to control the tertiary alcohol stereocenter, a challenging variant of that strategy in that both reacting partners were nonstandard (acetate enolate and ketone electrophile). A sequence consisting of Sonogashira coupling, acylation and hydrogenation delivered acetate 24, and Dieckmann cyclization provided β-keto lactone 2.

Published
2013
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