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4. Early and sensitive detection of PML-A216V mutation by droplet digital PCR in ATO-resistant acute promyelocytic leukemia

Author

Alfonso, V, Iaccarino, L, Ottone, T, Cicconi, L, Lavorgna, S, Divona, M, Cairoli, R, Cristiano, A, Ciardi, C, Travaglini, S, Falconi, G, Hasan, S, Venditti, A, Arcese, W, Voso, M, Lo-Coco, F, Alfonso V, Iaccarino L, Ottone T, Cicconi L, Lavorgna S, Divona M, Cairoli R, Cristiano A, Ciardi C, Travaglini S, Falconi G, Hasan SK, Venditti A, Arcese W, Voso MT, Lo-Coco F., Alfonso, V, Iaccarino, L, Ottone, T, Cicconi, L, Lavorgna, S, Divona, M, Cairoli, R, Cristiano, A, Ciardi, C, Travaglini, S, Falconi, G, Hasan, S, Venditti, A, Arcese, W, Voso, M, Lo-Coco, F, Alfonso V, Iaccarino L, Ottone T, Cicconi L, Lavorgna S, Divona M, Cairoli R, Cristiano A, Ciardi C, Travaglini S, Falconi G, Hasan SK, Venditti A, Arcese W, Voso MT, and Lo-Coco F.

Published
2019

5. SENSITIVE AND EARLY DETECTION OF THE PML-A216V MUTATION BY DROPLET DIGITAL PCR IN ARSENIC TRIOXIDE RESISTANT ACUTE PROMYELOCYTIC LEUKEMIA

Author

Alfonso, V, Iaccarino, L, Ottone, T, Cicconi, L, Lavorgna, S, Divona, M, Cairoli, R, Cristiano, A, Ciardi, C, Chiusolo, P, Venditti, A, Arcese, W, Voso, M, Lo Coco, F, Alfonso V, Iaccarino L, Ottone T, Cicconi L, Lavorgna S, Divona M, Cairoli R, Cristiano A, Ciardi C, Chiusolo P, Venditti A, Arcese W, Voso MT, Lo Coco F, Alfonso, V, Iaccarino, L, Ottone, T, Cicconi, L, Lavorgna, S, Divona, M, Cairoli, R, Cristiano, A, Ciardi, C, Chiusolo, P, Venditti, A, Arcese, W, Voso, M, Lo Coco, F, Alfonso V, Iaccarino L, Ottone T, Cicconi L, Lavorgna S, Divona M, Cairoli R, Cristiano A, Ciardi C, Chiusolo P, Venditti A, Arcese W, Voso MT, and Lo Coco F

Published
2018

6. Intra- and inter-observer variability in intracranial aneurysm segmentation: comparison between CT angiography (semi-automated segmentation software stroke VCAR) and digital subtraction angiography (3D rotational angiography)

Author

D'Argento, Francesco, Pedicelli, Alessandro, Ciardi, C., Leone, E., Scarabello, M., Infante, A., Alexandre, Andrea, Lozupone, Emilio, Valente, I., Colosimo, Cesare, D'Argento F., Pedicelli A. (ORCID:0000-0002-2558-8838), Alexandre A., Lozupone E., Colosimo C. (ORCID:0000-0003-3800-3648), D'Argento, Francesco, Pedicelli, Alessandro, Ciardi, C., Leone, E., Scarabello, M., Infante, A., Alexandre, Andrea, Lozupone, Emilio, Valente, I., Colosimo, Cesare, D'Argento F., Pedicelli A. (ORCID:0000-0002-2558-8838), Alexandre A., Lozupone E., and Colosimo C. (ORCID:0000-0003-3800-3648)

Abstract

Purpose: To compare size and morphologic features of three-dimensional aneurysm models, obtained with a semi-automated segmentation software (Stroke VCAR, GE, USA) from cerebral CT angiography (CTA) data, to three-dimensional aneurysm models obtained with digital subtraction angiography (DSA, with 3D rotational angiography acquisition—3DRA), considered as the reference standard. Methods: In this retrospective study, we reviewed 132 patients, with a total number of 137 intracranial aneurysm, who underwent CTA and subsequent DSA examination, supplemented with 3DRA. We compared neck length, short axis and long axis measured on 3DRA model to the same variables measured on 3D-CTA model by two blinded readers and to the automatic software dimensions. Therefore, statistics analysis assessed intra-observer and inter-observer variability and differences between patients with or without subarachnoid hemorrhage (SAH). Results: There were no significant differences in short-axis and long-axis measurements between 3D angiographic and 3D-CTA models, while comparison of neck lengths revealed a statistically significant difference, which tended to be greater for smaller neck lengths (partial volume effect and “kissing vessels” artifact). There were significant differences between manual and automatic data measured for the same three variables, and the presence of SAH did not affect aneurysm 3D reconstruction. Inter-observer agreement resulted moderate for neck length and substantial for short axis and long axis. Conclusion: The examined 3D-CTA segmentation system is a reproducible procedure for aneurysm morphologic characterization and, in particular, for assessment of aneurysm sac dimensions, but considerable carefulness is required in neck length interpretation.

Published
2020

8. Intra- and inter-observer variability in intracranial aneurysm segmentation: comparison between CT angiography (semi-automated segmentation software stroke VCAR) and digital subtraction angiography (3D rotational angiography)

Author

D’Argento, F., primary, Pedicelli, A., additional, Ciardi, C., additional, Leone, E., additional, Scarabello, M., additional, Infante, A., additional, Alexandre, A., additional, Lozupone, E., additional, Valente, I., additional, and Colosimo, C., additional

Published
2020
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9. SENSITIVE AND EARLY DETECTION OF THE PML-A216V MUTATION BY DROPLET DIGITAL PCR IN ARSENIC TRIOXIDE RESISTANT ACUTE PROMYELOCYTIC LEUKEMIA

Author

Alfonso, V., Iaccarino, L., Ottone, T., Cicconi, L., Lavorgna, S., Divona, M., Cairoli, R., Cristiano, A., Ciardi, C., Patrizia Chiusolo, Venditti, A., Arcese, W., Voso, M. T., Lo Coco, F., Alfonso, V, Iaccarino, L, Ottone, T, Cicconi, L, Lavorgna, S, Divona, M, Cairoli, R, Cristiano, A, Ciardi, C, Chiusolo, P, Venditti, A, Arcese, W, Voso, M, and Lo Coco, F

Subjects
hematology
Published
2018

13. Intra- and inter-observer variability in intracranial aneurysm segmentation: comparison between CT angiography (semi-automated segmentation software stroke VCAR) and digital subtraction angiography (3D rotational angiography).

Author

D'Argento, F., Pedicelli, A., Ciardi, C., Leone, E., Scarabello, M., Infante, A., Alexandre, A., Lozupone, E., Valente, I., and Colosimo, C.

Abstract

Purpose: To compare size and morphologic features of three-dimensional aneurysm models, obtained with a semi-automated segmentation software (Stroke VCAR, GE, USA) from cerebral CT angiography (CTA) data, to three-dimensional aneurysm models obtained with digital subtraction angiography (DSA, with 3D rotational angiography acquisition—3DRA), considered as the reference standard. Methods: In this retrospective study, we reviewed 132 patients, with a total number of 137 intracranial aneurysm, who underwent CTA and subsequent DSA examination, supplemented with 3DRA. We compared neck length, short axis and long axis measured on 3DRA model to the same variables measured on 3D-CTA model by two blinded readers and to the automatic software dimensions. Therefore, statistics analysis assessed intra-observer and inter-observer variability and differences between patients with or without subarachnoid hemorrhage (SAH). Results: There were no significant differences in short-axis and long-axis measurements between 3D angiographic and 3D-CTA models, while comparison of neck lengths revealed a statistically significant difference, which tended to be greater for smaller neck lengths (partial volume effect and "kissing vessels" artifact). There were significant differences between manual and automatic data measured for the same three variables, and the presence of SAH did not affect aneurysm 3D reconstruction. Inter-observer agreement resulted moderate for neck length and substantial for short axis and long axis. Conclusion: The examined 3D-CTA segmentation system is a reproducible procedure for aneurysm morphologic characterization and, in particular, for assessment of aneurysm sac dimensions, but considerable carefulness is required in neck length interpretation. [ABSTRACT FROM AUTHOR]

Published
2021
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18. PML-RAR alpha kinetics and impact of FLT3-ITD mutations in newly diagnosed acute promyelocytic leukaemia treated with ATRA and ATO or ATRA and chemotherapy

Author

Cicconi, L, Divona, M, Ciardi, C, Ottone, T, Ferrantini, A, Lavorgna, S, Alfonso, V, Paoloni, F, Piciocchi, A, Avvisati, G, Ferrara, F, Di Bona, E, Albano, F, Breccia, M, Cerqui, E, Sborgia, M, Kropp, Mg, Santoro, A, Levis, A, Sica, Simona, Amadori, S, Voso, Mt, Mandelli, F, Lo-Coco, F, Sica, S (ORCID:0000-0003-2426-3465), Cicconi, L, Divona, M, Ciardi, C, Ottone, T, Ferrantini, A, Lavorgna, S, Alfonso, V, Paoloni, F, Piciocchi, A, Avvisati, G, Ferrara, F, Di Bona, E, Albano, F, Breccia, M, Cerqui, E, Sborgia, M, Kropp, Mg, Santoro, A, Levis, A, Sica, Simona, Amadori, S, Voso, Mt, Mandelli, F, Lo-Coco, F, and Sica, S (ORCID:0000-0003-2426-3465)

Abstract

The APL0406 study showed that arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) are not inferior to standard ATRA and chemotherapy (CHT) in newly diagnosed, low-intermediaterisk acute promyelocytic leukaemia (APL). We analysed the kinetics of promyelocytic leukaemia-retinoic acid receptor-alpha (PML-RAR alpha) transcripts by real-time quantitative PCR (RQ-PCR) in bone marrow samples from 184 patients and assessed the prognostic impact of fms-related tyrosine kinase 3-internal tandem duplication (FLT3-ITD) in 159 patients enrolled in this trial in Italy. After induction therapy, the reduction of PML-RARa transcripts was significantly greater in patients receiving ATRA-CHT as compared with those treated with ATRA-ATO (3.4 vs 2.9 logs; P = 0.0182). Conversely, at the end of consolidation, a greater log reduction of PML-RAR alpha transcripts was detected in the ATRA-ATO as compared with the ATRA-CHT group (6.3 vs 5.3 logs; P = 0.0024). FLT3-ITD mutations had no significant impact on either event-free survival (EFS) or cumulative incidence of relapse in patients receiving ATRA-ATO, whereas a trend for inferior EFS was observed in FLT3-ITD-positive patients receiving ATRA-CHT. Our study shows at the molecular level that ATRA-ATO exerts at least equal and probably superior antileukaemic efficacy compared with ATRA-CHT in low-intermediaterisk APL. The data also suggest that ATRA-ATO may abrogate the negative prognostic impact of FLT3-ITD.

Published
2016

19. Identification of emerging FLT3 ITD-positive clones during clinical remission and kinetics of disease relapse in acute myeloid leukaemia with mutated nucleophosmin

Author

Ottone, Zaza, T, S, Divona, M, Hasan, S, Lavorgna, S, Laterza, S, Cicconi, L, Panetta, P, Di Giandomenico, J, Cittadini, M, Ciardi, C, Montefusco, E, Franchi, A, Annino, L, Venditti, A, Amadori, S, and LO COCO, F

Subjects
Oncology, FLT3 Internal Tandem Duplication, Adult, Male, NPM1, medicine.medical_specialty, Myeloid, Gene Dosage, Somatic evolution in cancer, law.invention, law, Recurrence, hemic and lymphatic diseases, Internal medicine, Gene Duplication, Gene duplication, medicine, Humans, Polymerase chain reaction, Retrospective Studies, business.industry, Induction chemotherapy, Nuclear Proteins, hemic and immune systems, Hematology, Induction Chemotherapy, Middle Aged, medicine.disease, body regions, Leukemia, Leukemia, Myeloid, Acute, medicine.anatomical_structure, fms-Like Tyrosine Kinase 3, embryonic structures, Immunology, Mutation, Female, business, Settore MED/15 - Malattie del Sangue, Nucleophosmin, psychological phenomena and processes
Abstract

FLT3 internal tandem duplication (ITD) mutations are frequently detected at diagnosis in cytogenetically normal acute myeloid leukaemia (CN-AML) and predict unfavourable outcome. FLT3 ITD is an unstable aberration and may be lost or acquired at relapse. Recent whole genome sequencing studies have suggested that FLT3 ITD(+)ve AML relapse may evolve from small subclones undetectable at diagnosis by routine polymerase chain reaction (PCR). We developed a patient-specific real-time quantitative-PCR (RQ-PCR) to implement FLT3 ITD detection in six AML patients whose blasts carried wild-type FLT3 at diagnosis and who relapsed with FLT3 ITD by routine PCR. Patient-specific forward primers were designed after cloning and sequencing the FLT3 ITD in each case. The assay allowed retrospective detection of FLT3 ITD in diagnostic samples of 4/6 cases and to establish the kinetics of clonal evolution preceding relapse. After conventional chemotherapy, all patients had early relapse despite having been classified as NPM1(+)ve/FLT3 ITD(-)ve at presentation, with shorter remissions being observed in four patients re-classified as FLT3 ITD(+)ve by the new assay. Notably, FLT3 ITD clone became detectable by conventional PCR in three patients tested during remission after initial treatment. Our data underscore the need of identifying low FLT3 ITD levels, which are probably associated with relapse in otherwise good prognosis CN-AML.

Published
2012

47. Ruthenium(II) π-Alkyne and Vinylidene Complexes Derived from Glycoynitols:  New Precursors for Water-Soluble Unsaturated Carbenes

Author

Ciardi, C., Reginato, G., Gonsalvi, L., Rios, I. de los, Romerosa, A., and Peruzzini, M.

Abstract

A new class of precursors for water-soluble unsaturated carbenes was synthesized by reaction of [Cp*RuCl(PMe3)2] with a terminal alkyne and a propargyl alcohol, each bearing a polyhydroxylated lateral chain derived from d-xylose. In the reaction with the terminal glycoynitol, the presence of a pair of noninterconverting π-alkyne intermediates of [Cp*Ru(PMe3)2]+ species was observed for the first time and the kinetics of isomerization to the same vinylidene species measured by NMR experiments.

Published
2004

50. Consensus on acute ischemic stroke,Consenso sobre accidente cerebrovascular isquémico agudo

Author

Pigretti, S. G., Alet, M. J., Mamani, C. E., Alonzo, C., Aguilar, M., Alvarez, H. J., Ameriso, S., Andrade, M. G., Arcondo, F., Armenteros, C., Arroyo, J., Beigelman, R., Bonardo, P., Bres Bullrich, M., Cabello, C., Camargo, G., Camerlingo, S., Cárdenas, R., Cháves, H., Ciardi, C., Ciarrochi, N., Cirio, J., Claverie, S., Colla Machado, P., Costilla, M., Díaz, M. F., Dossi, D., Gimenez, M. E., Giber, F., Gómez Schneider, M., González, L., Hlavnika, A., Ioli, P., Isaac, C. F., Izaguirre, A., Klein, F., Kuschner, P., Lerman, D., López, R., Marquevich, V., Miranda, J. C., Murgieri, M., Odzak, A., Pahnke, P., Persi, G., Pizzorno, J., Pollan, J., Virginia Pujol Lereis, Requejo, F., Robledo, L., Rosales, J., Rubin, R., Sabio, R., Tejada Jacob, V., Tumino, L., Valdez, P., Videtta, W., Vilela, A., Villaroel Saavedra, V., Winkel, M., and Zurrú, M. C.

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