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1. ECG/echo indexes in the diagnostic approach to amyloid cardiomyopathy: A head-to-head comparison from the AC-TIVE study

Author

Pagura, L, Porcari, A, Cameli, M, Biagini, E, Canepa, M, Crotti, L, Imazio, M, Forleo, C, Pavasini, R, Limongelli, G, Perlini, S, Metra, M, Boriani, G, Emdin, M, Sinagra, G, Merlo, M, Longo, F, Rossi, M, Varrà, G, Saro, R, Dore, F, Girardi, F, Vergaro, G, Musumeci, B, Autore, C, Cappelli, F, Perfetto, F, Olivotto, I, Favale, S, Carella, M, Guaricci, A, Ciccone, M, Di Bella, G, Tomasoni, D, Rella, V, Branzi, G, Badano, L, Parati, G, Palmiero, G, Caiazza, M, Caponetti, A, Saturi, G, Labate, M, Andreis, A, Paneva, E, De Ferrari, G, Di Ienno, L, De Carli, G, Giacomin, E, Arzilli, C, Pagura L., Porcari A., Cameli M., Biagini E., Canepa M., Crotti L., Imazio M., Forleo C., Pavasini R., Limongelli G., Perlini S., Metra M., Boriani G., Emdin M., Sinagra G., Merlo M., Longo F., Rossi M., Varrà G. G., Saro R., Dore F., Girardi F., Vergaro G., Musumeci B., Autore C., Cappelli F., Perfetto F., Olivotto I., Favale S., Carella M. C., Guaricci A. I., Ciccone M. M., Di Bella G., Tomasoni D., Rella V., Branzi G., Badano L., Parati G., Palmiero G., Caiazza M., Caponetti A. G., Saturi G., Labate M. E., Andreis A., Paneva E., De Ferrari G. M., Di Ienno L., De Carli G., Giacomin E., Arzilli C., Pagura, L, Porcari, A, Cameli, M, Biagini, E, Canepa, M, Crotti, L, Imazio, M, Forleo, C, Pavasini, R, Limongelli, G, Perlini, S, Metra, M, Boriani, G, Emdin, M, Sinagra, G, Merlo, M, Longo, F, Rossi, M, Varrà, G, Saro, R, Dore, F, Girardi, F, Vergaro, G, Musumeci, B, Autore, C, Cappelli, F, Perfetto, F, Olivotto, I, Favale, S, Carella, M, Guaricci, A, Ciccone, M, Di Bella, G, Tomasoni, D, Rella, V, Branzi, G, Badano, L, Parati, G, Palmiero, G, Caiazza, M, Caponetti, A, Saturi, G, Labate, M, Andreis, A, Paneva, E, De Ferrari, G, Di Ienno, L, De Carli, G, Giacomin, E, Arzilli, C, Pagura L., Porcari A., Cameli M., Biagini E., Canepa M., Crotti L., Imazio M., Forleo C., Pavasini R., Limongelli G., Perlini S., Metra M., Boriani G., Emdin M., Sinagra G., Merlo M., Longo F., Rossi M., Varrà G. G., Saro R., Dore F., Girardi F., Vergaro G., Musumeci B., Autore C., Cappelli F., Perfetto F., Olivotto I., Favale S., Carella M. C., Guaricci A. I., Ciccone M. M., Di Bella G., Tomasoni D., Rella V., Branzi G., Badano L., Parati G., Palmiero G., Caiazza M., Caponetti A. G., Saturi G., Labate M. E., Andreis A., Paneva E., De Ferrari G. M., Di Ienno L., De Carli G., Giacomin E., and Arzilli C.

Abstract

Background and aims: The discordance between QRS voltages on electrocardiogram (ECG) and left ventricle (LV) wall thickness (LVWT) on echocardiogram (echo) is a recognized red flag (RF) of amyloid cardiomyopathy (AC) and can be measured by specific indexes. No head-to-head comparison of different ECG/echo indexes among subjects with echocardiographic suspicion of AC has yet been undertaken. The study aimed at evaluating the performance and the incremental diagnostic value of different ECG/echo indexes in this subset of patients. Methods: Electrocardiograms of subjects with LV hypertrophy, preserved ejection fraction and ≥ 1 echocardiographic RF of AC participating in the AC-TIVE study, an Italian prospective multicenter study, were independently analyzed by two cardiologists. Low QRS voltages and 8 different ECG/echo indexes were evaluated. Cohort specific cut-offs were computed. Results: Among 170 patients, 55 (32 %) were diagnosed with AC. Combination of low QRS voltages with interventricular septum ≥ 1,6 cm was the most specific (specificity 100 %, positive predictive value 100 %) ECG/echo index, while the ratio between the sum of all QRS voltages and LVWT <7,8 was the most sensitive and accurate (sensitivity 94 %, negative predictive value 97 %, accuracy 82 %). When the latter index was added to a model using easily-accessible clinical variables, the diagnostic accuracy for AC greatly increased (AUC from 0,84 to 0,95; p = 0,007). Conclusions: Among patients with non-dilated hypertrophic ventricles with normal ejection fraction and echocardiographic RF of AC, easily-measurable ECG/echo indexes, mainly when added to few clinical variables, can help the physician orient second level investigations. External validation of the results is warranted.

Published
2024

3. Efficacy, safety, adherence and persistence of PCSK9 inhibitors in clinical practice: a single country, multicenter, observational study (AT-TARGET-IT)

Author

Gargiulo, P, primary, Basile, C, additional, Calabro', P, additional, Catalano, A, additional, Merlini, P A, additional, Iannuzzo, G, additional, Ciccone, M M, additional, Paloscia, L, additional, Varbella, F, additional, Brunetti, N D, additional, Paolillo, S, additional, Marzano, F, additional, Indolfi, C, additional, and Perrone-Filardi, P, additional

Published
2023
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4. Efficacy and safety of inclisiran in real world practice: insights from the Cholinet registry

Author

Basile, C, primary, Gargiulo, P, additional, Merlini, P A, additional, Brunetti, N D, additional, Musumeci, G, additional, Casu, G, additional, Galasso, G, additional, Varbella, F, additional, Calabro', P, additional, Ciccone, M M, additional, Calo', L, additional, Bilato, C, additional, Paolillo, S, additional, Indolfi, C, additional, and Perrone-Filardi, P, additional

Published
2023
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5. Left Ventricular Global Longitudinal Strain (LV GLS) assessed by Echocardiography predicts myocardial fibrosis and iron overload in transfusion dependent beta-thalassemia patients

Author

Guaricci, A I, primary, Basile, P, additional, Monitillo, F, additional, Dadamo, M L, additional, Giordano, P, additional, Santoro, D, additional, Di Gennaro, D, additional, Mushtaq, S, additional, Baggiano, A, additional, Fazzari, F, additional, Fusini, L, additional, Forleo, C, additional, Vitucci, A, additional, Pontone, G, additional, and Ciccone, M M, additional

Published
2023
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7. Come superare le barriere all'implementazione delle strategie di prevenzione e cura della malattia cardiovascolare aterosclerotica mediante terapia ipolipemizzante

Author

Arca, M, Averna, M, Borghi, C, Lettino, M, Filardi, P, Alberti, A, Bilato, C, Calabrò, P, Carubbi, F, Ciccone, M, Cipollone, F, Citroni, N, De Luca, L, Giaccari, A, Iannuzzo, G, Maloberti, A, Marcucci, R, Spinazzola, P, Pirro, M, Pisciotta, L, Sarullo, F, Sciacqua, A, Suppressa, P, Varbella, F, Werba, J, Zambon, A, Arca M., Averna M., Borghi C., Lettino M., Filardi P. P., Alberti A., Bilato C., Calabrò P., Carubbi F., Ciccone M. M., Cipollone F., Citroni N., De Luca L., Giaccari A., Iannuzzo G., Maloberti A., Marcucci R., Spinazzola P. P., Pirro M., Pisciotta L., Sarullo F., Sciacqua A., Suppressa P., Varbella F., Werba J. P., Zambon A., Arca, M, Averna, M, Borghi, C, Lettino, M, Filardi, P, Alberti, A, Bilato, C, Calabrò, P, Carubbi, F, Ciccone, M, Cipollone, F, Citroni, N, De Luca, L, Giaccari, A, Iannuzzo, G, Maloberti, A, Marcucci, R, Spinazzola, P, Pirro, M, Pisciotta, L, Sarullo, F, Sciacqua, A, Suppressa, P, Varbella, F, Werba, J, Zambon, A, Arca M., Averna M., Borghi C., Lettino M., Filardi P. P., Alberti A., Bilato C., Calabrò P., Carubbi F., Ciccone M. M., Cipollone F., Citroni N., De Luca L., Giaccari A., Iannuzzo G., Maloberti A., Marcucci R., Spinazzola P. P., Pirro M., Pisciotta L., Sarullo F., Sciacqua A., Suppressa P., Varbella F., Werba J. P., and Zambon A.

Abstract

Atherosclerotic cardiovascular diseases remain the main cause of mortality worldwide, due to a poor control of modifiable risk factors for atherosclerosis. High levels of low-density lipoprotein cholesterol represent the most relevant actor in the development of atherosclerotic cardiovascular diseases, as well as the main target promuovoof prevention strategies. Although lipid-lowering treatments were shown to be effective for cardiovascular prevention, several barriers (e.g. clinician reluctance to prescribe an intensive treatment, poor adherence of patients to therapy, high pharmacotherapy burden of high-risk patients and the fear for adverse events potentially associated with statins) still prevent therapy optimization. Such issues will be addressed in this review article, taking into account possible strategies for their solution, through an integrated approach including both management interventions and a larger use of the available pharmacologic options.

Published
2023

8. Efficacy, safety, adherence and persistence of PCSK9 inhibitors in clinical practice: A single country, multicenter, observational study (AT-TARGET-IT)

Author

Gargiulo, P, Basile, C, Cesaro, A, Marzano, F, Buonocore, D, Asile, G, Abbate, V, Vicidomini, F, Paolillo, S, Spaccarotella, C, Catalano, A, Spirito, G, Merlini, P, Maloberti, A, Iannuzzo, G, Ciccone, M, Zito, A, Paloscia, L, D'Alleva, A, Varbella, F, Corleto, A, Brunetti, N, Corbo, M, Calabro, P, Indolfi, C, Perrone-Filardi, P, Gargiulo P., Basile C., Cesaro A., Marzano F., Buonocore D., Asile G., Abbate V., Vicidomini F., Paolillo S., Spaccarotella C. A. M., Catalano A., Spirito G., Merlini P. A., Maloberti A., Iannuzzo G., Ciccone M. M., Zito A. P., Paloscia L., D'Alleva A., Varbella F., Corleto A., Brunetti N. D., Corbo M. D., Calabro P., Indolfi C., Perrone-Filardi P., Gargiulo, P, Basile, C, Cesaro, A, Marzano, F, Buonocore, D, Asile, G, Abbate, V, Vicidomini, F, Paolillo, S, Spaccarotella, C, Catalano, A, Spirito, G, Merlini, P, Maloberti, A, Iannuzzo, G, Ciccone, M, Zito, A, Paloscia, L, D'Alleva, A, Varbella, F, Corleto, A, Brunetti, N, Corbo, M, Calabro, P, Indolfi, C, Perrone-Filardi, P, Gargiulo P., Basile C., Cesaro A., Marzano F., Buonocore D., Asile G., Abbate V., Vicidomini F., Paolillo S., Spaccarotella C. A. M., Catalano A., Spirito G., Merlini P. A., Maloberti A., Iannuzzo G., Ciccone M. M., Zito A. P., Paloscia L., D'Alleva A., Varbella F., Corleto A., Brunetti N. D., Corbo M. D., Calabro P., Indolfi C., and Perrone-Filardi P.

Abstract

Background and aims: Proprotein Convertase Subtilisin/Kexin type 9 inhibitors (PCSK9i) are recommended in patients at high and very-high cardiovascular (CV) risk, with documented atherosclerotic CV disease (ASCVD), and for very-high risk patients with familial hypercholesterolaemia not achieving LDL-cholesterol (LDL-C) goal while receiving maximally tolerated dose of lipid-lowering therapy (LLT). However, single country real-life data, reporting the use of PCSK9i in clinical practice, are limited. Therefore, we designed AT-TARGET-IT, an Italian, multicenter, observational registry on the use of PCSK9i in clinical practice. Methods: All data were recorded at the time of the first prescription and at the latest observation preceding inclusion in the study. Results: 798 patients were enrolled. The median reduction in LDL-C levels was 64.9%. After stratification for CV risk, 63.8% achieved LDL-C target; of them, 83.3% took LLTs at PCSK9i initiation and 16.7% did not. 760 patients (95.2%) showed high adherence to therapy, 13 (1.6%) partial adherence, and 25 (3.1%) poor adherence. At 6 months, 99.7% of patients enrolled in the study remained on therapy; there were 519 and 423 patients in the study with a follow-up of at least 12 and 18 months, respectively. Persistence in these groups was 98.1% and 97.5%, respectively. Overall, 3.5% of patients discontinued therapy. No differences in efficacy, adherence, and persistence were found between alirocumab and evolocumab. Conclusions: PCSK9i are safe and effective in clinical practice, leading to very high adherence and persistence to therapy, and achievement of recommended LDL-C target in most patients, especially when used as combination therapy.

Published
2023

9. PCSK9 inhibitors: effectiveness of treatment and changes in background lipid-lowering therapy in a real world Italian population. The AT-TARGET-IT study

Author

Perrone-Filardi, P, primary, Basile, C, additional, Asile, G, additional, Abbate, C, additional, Catalano, A, additional, Merlini, P A, additional, Calabro', P, additional, Iannuzzo, G, additional, Ciccone, M M, additional, Paloscia, L, additional, Varbella, F, additional, Brunetti, N D, additional, Indolfi, C, additional, Paolillo, S, additional, and Gargiulo, P, additional

Published
2022
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10. Italian Society of Cardiology (SIC) Expert consensus document: Post-acute cardiovascular sequelae of SARS-CoV-2 infection

Author

Indolfi C., Barilla F., Basso C., Ciccone M. M., Curcio A., Gargiulo P., Nodari S., Mercuro G., Mancone M., Muscoli S., Pedrinelli R., Porcari A., Spaccarotella C., Romeo F., Sinagra G., Filardi P. P., Indolfi, C., Barilla, F., Basso, C., Ciccone, M. M., Curcio, A., Gargiulo, P., Nodari, S., Mercuro, G., Mancone, M., Muscoli, S., Pedrinelli, R., Porcari, A., Spaccarotella, C., Romeo, F., Sinagra, G., and Filardi, P. P.

Abstract

Although the clinical course of COVID-19 in its acute phase is now delineated, less known is its late phase characterized by a heterogeneous series of sequelae affecting various organs and systems, including the cardiovascular system, which continue after the acute episode or arise after their resolution. This syndrome, now referred with the new acronym "PASC" (post-acute sequelae of SARS-CoV-2 infection) has been formally recognized by various scientific societies and international organizations that have proposed various definitions. The World Health Organization defines PASC, distinguishing it from "ongoing symptomatic COVID-19", as a condition that arises few weeks after infection, persists at least 8 weeks, and cannot be explained by alternative diagnoses.There are multiple mechanisms responsible for PASC: inflammation, immune activation, viral persistence, activation of latent viruses, endothelial dysfunction, impaired response to exercise, and profound cardiac deconditioning following viral infection. The key symptoms of PASC are palpitations, effort dyspnea, chest pain, exercise intolerance, and postural orthostatic tachycardia syndrome.For PASC treatment, it may be useful to take salt and fluid loading, to reduce symptoms such as tachycardia, palpitations, and/or orthostatic hypotension, or in some subjects the use of drugs such as beta-blockers, non-dihydropyridine calcium channel blockers, ivabradine, and fludrocortisone.Finally, in PASC a gradual resumption of physical activity is recommended, starting with recumbent or semi-recumbent exercise, such as cycling, swimming, or rowing, and then moving on to exercise in an upright position such as running when the ability to stand improves without dyspnea appearance. Exercise duration should also be short initially (5 to 10 min per day), with gradual increases as functional capacity improves.

Published
2022

11. [Italian Society of Cardiology-Italian Society of Nephrology Consensus document: The cardio-renal interaction in the prevention and treatment of cardiovascular diseases - Part II: From preventive strategies to treatment of patients with cardio-renal damage]

Author

Indolfi C., Barilla F., Basile C., Basso C., Cantaluppi V., Capasso G., Ciccone M. M., Contessi S., Curcio A., De Nicola L., Esposito C., Imeraj A., Lecis D., Mancone M., Marengo M., Mercuro G., Merlo M., Metra M., Adamo M., Muscoli S., Nodari S., Pagura L., Paoletti E., Paolillo S., Pedrinelli R., Filardi P. P., Pertosa G. B., Pezzato A., Pontremoli R., Romeo F., Ruggenenti P., Ronco C., Santoro A., Sinagra G., Spaccarotella C., Zippo D., Zoccali C., Messa P., Indolfi, C., Barilla, F., Basile, C., Basso, C., Cantaluppi, V., Capasso, G., Ciccone, M. M., Contessi, S., Curcio, A., De Nicola, L., Esposito, C., Imeraj, A., Lecis, D., Mancone, M., Marengo, M., Mercuro, G., Merlo, M., Metra, M., Adamo, M., Muscoli, S., Nodari, S., Pagura, L., Paoletti, E., Paolillo, S., Pedrinelli, R., Filardi, P. P., Pertosa, G. B., Pezzato, A., Pontremoli, R., Romeo, F., Ruggenenti, P., Ronco, C., Santoro, A., Sinagra, G., Spaccarotella, C., Zippo, D., Zoccali, C., and Messa, P.

Subjects
Diabetes mellitu, Consensus, Cardiology, Contrast Media, Cardiovascular disease, Atrial fibrillation, Cardiovascular Diseases, Nephrology, Acute kidney disease, Chronic kidney disease, Humans, Renal Insufficiency, Chronic, Renal Insufficiency, Hyperkaliemia, Chronic
Abstract

Chronic kidney disease and cardiovascular disease are strictly connected each other with a bidirectional interaction. Thus, the prevention of cardio-renal damage, as its appropriate treatment, are essential steps for a correct management of long-term patients' prognosis. Several preventive and therapeutic strategies, pharmacological and not, are now available for cardio-renal damage prevention and treatment, and for the management of its complications. The second part of this consensus document focuses on the management and treatment of cardio-renal damage, directing the attention on the correct use of drugs that may slow renal disease progression, on the application of preventive strategies in case of invasive cardiac procedures with the use of contrast agents, and on the accurate use of cardiological drugs in patients with chronic kidney disease.

Published
2022

13. Position paper of the Italian Society of Cardiology (SIC) on COVID-19 vaccine priority in patients with cardiovascular diseases

Author

Indolfi C., Barilla F., Basso C., Ciccone M. M., Curcio A., Mancone M., Mercuro G., Muscoli S., Nodari S., Pedrinelli R., Sinagra G., Filardi P. P., Romeo F., Indolfi, C., Barilla, F., Basso, C., Ciccone, M. M., Curcio, A., Mancone, M., Mercuro, G., Muscoli, S., Nodari, S., Pedrinelli, R., Romeo, F., Sinagra, G., and Filardi, P. P.

Subjects
Cardiovascular diseases, COVID-19, SARS-CoV-2, Vaccine, Age Factors, Animals, COVID-19 Vaccines, Cardiology, Cardiovascular Diseases, Coronary Disease, Disease Vectors, Heart Failure, Heart Transplantation, Heart Valve Diseases, Humans, Hypertension, Pulmonary, Italy, Prognosis, Renal Insufficiency, Societies, Medical, Vaccines, Synthetic, Consensus, Prognosi, COVID-19 Vaccine, Medical, Age Factor, Disease Vector, Vaccines, Animal, Synthetic, Pulmonary, Cardiovascular disease, Heart Valve Disease, Hypertension, Societies, Human
Abstract

In over a year, the COVID-19 pandemic caused 2.69 million deaths and 122 million infections. Social isolation and distancing measures have been the only prevention available for months. Scientific research has done a great deal of work, developing in a few months safe and effective vaccines against COVID-19. In the European Union, nowadays, four vaccines have been authorized for use: Pfizer-BioNTech, Moderna, ChAdOx1 (AstraZeneca/Oxford), Janssen (Johnson & Johnson), and three others are currently under rolling review. Vaccine allocation policy is crucial to optimize the advantage of treatment preferring people with the highest risk of contagion. These days the priority in the vaccination program is of particular importance since it has become clear that the number of vaccines is not sufficient for the entire Italian population in the short term. Cardiovascular diseases are frequently associated with severe COVID-19 infections, leading to the worst prognosis. The elderly population suffering from cardiovascular diseases is, therefore, to be considered a particularly vulnerable population. However, age cannot be considered the only discriminating factor because in the young-adult population suffering from severe forms of heart disease, the prognosis, if affected by COVID-19, is particularly ominous and these patients should have priority access to the vaccination program. The aim of this position paper is to establish a consensus on a priority in the vaccination of COVID-19 among subjects suffering from different cardiovascular diseases.

Published
2021

17. Continuous flow left ventricular assist devices do not worsen endothelial function in subjects with chronic heart failure: a pilot study

Author

Cortese, F, Ciccone, M, Gesualdo, M, Iacoviello, M, Frigerio, M, Cipriani, M, Giannattasio, C, Maloberti, A, Giordano, P, Cortese F., Ciccone M. M., Gesualdo M., Iacoviello M., Frigerio M., Cipriani M., Giannattasio C., Maloberti A., Giordano P., Cortese, F, Ciccone, M, Gesualdo, M, Iacoviello, M, Frigerio, M, Cipriani, M, Giannattasio, C, Maloberti, A, Giordano, P, Cortese F., Ciccone M. M., Gesualdo M., Iacoviello M., Frigerio M., Cipriani M., Giannattasio C., Maloberti A., and Giordano P.

Abstract

Aims: To evaluate endothelial function in subjects with left ventricular assist devices (LVADs), comparing them with subjects with chronic heart failure with reduced ejection fraction on the list for heart transplant (HT) and with HT patients with a normal systolic cardiac function to identify any differences. Methods: We enrolled 28 subjects with LVAD, 55 subjects with HT, and 42 subjects with heart failure on the transplant list. The subjects underwent a general physical examination, assessment of laboratory blood parameters, and assessment of endothelial function through flow-mediated dilation (FMD) of brachial artery. Results: The three groups were homogeneous as regards age, gender, smoke abuse, C-reactive protein (CRP) and FMD parameters (P = ns). In LVAD group percentage of FMD change showed an inverse correlation with CRP (rho: −0.5, P: 0.003), a well-known marker of inflammation and tissue damage. Conclusions: Continuous flow related to LVAD seems to not worsen endothelial function. Endothelial function was not affected by cardiovascular risk factors (hypertension, hypercholesterolaemia, diabetes, obesity, and tobacco habit), by the functional status expressed by New York Heart Association class, by the left ventricular systolic function and by the presence or absence of ischaemic heart disease in all the populations analysed. CRP was the only factor able to influence percentage of FMD change in patient with LVAD, reinforcing the hypothesis that inflammation is the main determinant of endothelial function.

Published
2021

21. When should cardiovascular prevention begin? The importance of antenatal, perinatal and primordial prevention

Author

D'Ascenzi, F, Sciaccaluga, C, Cameli, M, Cecere, A, Ciccone, M, Di Francesco, S, Ganau, A, Imbalzano, E, Liga, R, Palermo, P, Palmiero, P, Parati, G, Pedrinelli, R, Scicchitano, P, Zito, A, Mattioli, A, D'Ascenzi F., Sciaccaluga C., Cameli M., Cecere A., Ciccone M. M., Di Francesco S., Ganau A., Imbalzano E., Liga R., Palermo P., Palmiero P., Parati G., Pedrinelli R., Scicchitano P., Zito A., Mattioli A. V., D'Ascenzi, F, Sciaccaluga, C, Cameli, M, Cecere, A, Ciccone, M, Di Francesco, S, Ganau, A, Imbalzano, E, Liga, R, Palermo, P, Palmiero, P, Parati, G, Pedrinelli, R, Scicchitano, P, Zito, A, Mattioli, A, D'Ascenzi F., Sciaccaluga C., Cameli M., Cecere A., Ciccone M. M., Di Francesco S., Ganau A., Imbalzano E., Liga R., Palermo P., Palmiero P., Parati G., Pedrinelli R., Scicchitano P., Zito A., and Mattioli A. V.

Abstract

Cardiovascular diseases represent a major health problem, being one of the leading causes of morbidity and mortality worldwide. Therefore, in this scenario, cardiovascular prevention plays an essential role although it is difficult to establish when promoting and implementing preventive strategies. However, there is growing evidence that prevention should start even before birth, during pregnancy, aiming to avoid the onset of cardiovascular risk factors, since events that occur early in life have a great impact on the cardiovascular risk profile of an adult. The two pillars of this early preventive strategy are nutrition and physical exercise, together with prevention of cardio-metabolic diseases during pregnancy. This review attempts to gather the growing evidence of the benefits of antenatal, perinatal and primordial prevention, discussing also the possibility to reverse or to mitigate the cardiovascular profile developed in the initial stages of life. This could pave the way for future research, investigating the optimal time and duration of these preventing measures, their duration and maintenance in adulthood, and the most effective interventions according to the different age and guiding in the next years, the best clinical practice and the political strategies to cope with cardiovascular disease.

Published
2019

22. Cardiovascular prevention in women: A narrative review from the Italian Society of Cardiology working groups on 'Cardiovascular Prevention, Hypertension and peripheral circulation' and on 'Women Disease'

Author

Mattioli, A, Sciomer, S, Moscucci, F, Maiello, M, Cugusi, L, Gallina, S, Dei Cas, A, Lombardi, C, Pengo, M, Parati, G, Barilla, F, Ciccone, M, Palmiero, P, Mercuro, G, Maffei, S, Mattioli A. V., Sciomer S., Moscucci F., Maiello M., Cugusi L., Gallina S., Dei Cas A., Lombardi C., Pengo M., Parati G., Barilla F., Ciccone M. M., Palmiero P., Mercuro G., Maffei S., Mattioli, A, Sciomer, S, Moscucci, F, Maiello, M, Cugusi, L, Gallina, S, Dei Cas, A, Lombardi, C, Pengo, M, Parati, G, Barilla, F, Ciccone, M, Palmiero, P, Mercuro, G, Maffei, S, Mattioli A. V., Sciomer S., Moscucci F., Maiello M., Cugusi L., Gallina S., Dei Cas A., Lombardi C., Pengo M., Parati G., Barilla F., Ciccone M. M., Palmiero P., Mercuro G., and Maffei S.

Abstract

Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in women.Some authors highlighted that the female risk profile consists of traditional and emerging risk factors. Despite the lower prevalence of type 2 diabetes, years of life lost owing to the disease for women are substantially higher compared with men. In addition, pregnancy complicated by gestational diabetes represents a risk factor for CVD. Women with gestational diabetes have a higher prevalence of coronary artery disease that occur at a younger age and are independent of T2DM.Hypertension is an important cardiovascular risk factor in women. Estrogens and progesterone, known to have an impact on blood pressure levels, have also been proposed to be protective against sleep-disordered breathing. It is very difficult to understand whereas obstructive sleep apnea in women is independently associated with hypertension or if many confounders acting at different stages of the woman lifespan mediate this relation.The cardioprotective effect of physical activity in women of all ages is well known. Women are generally more physically inactive than men. During and after menopause, most women tend to reduce their physical activity levels and together with the reduction in basal metabolic rate, women experience loss of skeletal muscle mass with a negative change in the ratio of fat-to-lean mass.In conclusion, sex differences in the cardiovascular system are because of dissimilarities in gene expression and sex hormones; these result in variations in prevalence and presentation of CVD and associated conditions, such as diabetes, hypertension and vascular and cardiac remodeling.Changes in lifestyle and increase in physical activity could help in prevention of cardiovascular disease in women.

Published
2019

28. P4710Quality of life and left atrial function in patient with chronic heart failure: the echocardiographic multicentric FLASH study

Author

Cameli, M, primary, Mandoli, G E, additional, Sciaccaluga, C, additional, Loiacono, F, additional, Bandera, F, additional, Emdin, M, additional, Giannoni, A, additional, Simova, I, additional, Nistor, D, additional, Lisi, M, additional, Miglioranza, M, additional, Devito, F, additional, Ciccone, M M, additional, Guaricci, A I, additional, and Mondillo, S, additional

Published
2018
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29. Idiopathic sudden sensorineural hearing loss and ménière syndrome: The role of cerebral venous drainage

Author

Ciccone, M. M., primary, Scicchitano, P., additional, Gesualdo, M., additional, Cortese, F., additional, Zito, A., additional, Manca, F., additional, Boninfante, B., additional, Recchia, P., additional, Leogrande, D., additional, Viola, D., additional, Damiani, M., additional, Gambacorta, V., additional, Piccolo, A., additional, De Ceglie, V., additional, and Quaranta, N., additional

Published
2017
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34. Altered two-dimensional strain measures of the right ventricle in patients with Brugada syndrome and arrhythmogenic right ventricular dysplasia/cardiomyopathy

Author

Iacoviello, M., primary, Forleo, C., additional, Puzzovivo, A., additional, Nalin, I., additional, Guida, P., additional, Anaclerio, M., additional, Marangelli, V., additional, Sorrentino, S., additional, Monitillo, F., additional, Ciccone, M. M., additional, and Favale, S., additional

Published
2011
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35. Abstracts

Author

Barthelemy, O., primary, Silvain, J., additional, Brieger, D., additional, Bellemain-Appaix, A., additional, Cayla, G., additional, Beygui, F., additional, Lancar, R., additional, Collet, J. P., additional, Mercadier, A., additional, Montalescot, G., additional, Cha, K. S., additional, Nam, Y. H., additional, Kim, J. H., additional, Park, S. Y., additional, Park, T. H., additional, Kim, M. H., additional, Kim, Y. D., additional, Lee, H. C., additional, Ahn, M. S., additional, Hong, T. J., additional, Blanco, R., additional, Blanco, F., additional, Szarfer, J., additional, Garcia Escudero, A., additional, Gigena, G., additional, Gagliardi, J., additional, Rodriguez, A., additional, Sarmiento, R., additional, Affatatto, S., additional, Riccitelli, M., additional, Petris, A., additional, Datcu, M. D., additional, Pop, C., additional, Radoi, M., additional, Arsenescu-Georgescu, C., additional, Petrescu, I., additional, Petrescu, L., additional, Serban, L., additional, Nechita, E., additional, Tatu-Chitoiu, G., additional, Dorobantu, M., additional, Benedek, I., additional, Craiu, E., additional, Sinescu, C., additional, Ionescu, D. D., additional, Ginghina, C., additional, Minescu, B., additional, Izzo, A., additional, Mantovani, P., additional, Tomasi, L., additional, Dall'oglio, L., additional, Bonatti, S., additional, Rosiello, R., additional, Romano, M., additional, Agostini, F., additional, Zanini, R., additional, Zhao, Z. Y., additional, Wu, Y. J., additional, Li, J. J., additional, Yany, Y. J., additional, Qian, H. Y., additional, Tang, Y. D., additional, Timoteo, A. T., additional, Toste, A., additional, Lousinha, A., additional, Ramos, R., additional, Oliveira, J. A., additional, Ferreira, M. L., additional, Ferreira, R. C., additional, Cabades, C., additional, Diez Gil, J. L., additional, Aguar, P., additional, Sanmiguel, D., additional, Lopez-March, A., additional, Marmol, R., additional, Guerra, L., additional, Girbes, V., additional, Ferrando, J., additional, Rincon De Arellano, A., additional, Patricio, L., additional, Blondal, M., additional, Ainla, T., additional, Marandi, T., additional, Eha, J., additional, Oliveira, M. M., additional, Silva, M. N., additional, Cunha, P. S., additional, Feliciano, J., additional, Silva, S., additional, Kanovsky, J., additional, Kala, P., additional, Parenica, J., additional, Poloczek, M., additional, Prymusova, K., additional, Kubkova, L., additional, Spinar, J., additional, Olinic, D., additional, Homorodean, C., additional, Ober, M., additional, Olinic, M., additional, Andrioaia, C., additional, Condac, A., additional, Masmoudi, M., additional, Berdaoui, B., additional, Labidi, S., additional, Tapia Ballesteros, C., additional, Hernandez Luis, C., additional, Sandin, M. G., additional, Vegas, J. M., additional, Andion, R., additional, Martinez, N., additional, Gonzalez, I. A., additional, Alvarado, M., additional, Amat, I. J., additional, San Roman, J. A., additional, Garcia Gonzalez, M. J., additional, Arroyo Ucar, E., additional, Hernandez Garcia, C., additional, Dorta Martin, M., additional, Marrero Rodriguez, F., additional, Dragu, R., additional, Kapeliovich, M., additional, Hammerman, H., additional, Silva, D., additional, Cortez-Dias, N., additional, Jorge, C., additional, Silva Marques, J., additional, Carilho Ferreira, P., additional, Robalo Martins, S., additional, Almeida Ribeiro, M., additional, Calisto, C., additional, Fiuza, M., additional, Lopes, M. G., additional, Milicevic, P., additional, Panic, M., additional, Stankovic, I., additional, Milicevic, D., additional, Kalezic, T., additional, Kafedzic, S., additional, Ilic, I., additional, Cerovic, M., additional, Putnikovic, B., additional, Neskovic, A., additional, Rott, D., additional, Leibowitz, D., additional, Monhart, Z., additional, Reissigova, J., additional, Grunfeldova, H., additional, Jansky, P., additional, Valente, B., additional, Villanueva Benito, I., additional, Solla, I., additional, Paredes, E., additional, Diaz Castro, O., additional, Calvo, F., additional, Baz, J. A., additional, Iniguez, A., additional, Aleksova, A., additional, Gerloni, R., additional, Belfiore, R., additional, Carriere, C., additional, Barbati, G., additional, Fabris, E., additional, Possa, F., additional, Nait, D., additional, Milo, M., additional, Sinagra, G., additional, Marques, N., additional, Mimoso, J., additional, Gomes, V., additional, Agra Bermejo, R. M., additional, Emad Abu Assi, E. A. A., additional, Sergio Raposeiras Roubin, S. R. R., additional, Pilar Cabanas Grandio, P. C. G., additional, Carlos Pena Gil, C. P. G., additional, Jose Maria Garcia Acuna, J. M. G. A., additional, Jose Ramon Gonzalez Juanatey, J. R. G. J., additional, Daly, M. J., additional, Scott, P., additional, Owens, C. G., additional, Tomlin, A., additional, Smith, B., additional, Adgey, A. A. J., additional, Alvarez-Contreras, L. R., additional, Juarez, U., additional, Altamirano, A., additional, Arias, A., additional, Alvarez-San Gabriel, A., additional, Gonzalez-Pacheco, H., additional, Martinez-Sanchez, C., additional, Rahnavardi, M., additional, Keshtkar-Jahromi, M., additional, Vakili, H., additional, Gholamin, S., additional, Razavi, S. M., additional, Gilis-Januszewski, T., additional, Mellwig, K.- P., additional, Wiemer, M., additional, Gilis-Januszewski, J., additional, Peterschroeder, A., additional, Koerfer, J., additional, Horstkotte, D., additional, Vrsalovic, M., additional, Getaldic, B., additional, Vrkic, N., additional, Pintaric, H., additional, Khan, S., additional, Wasan, B., additional, Moretti, L., additional, Grossi, P., additional, Silenzi, S., additional, Testa, M., additional, Candelori, L., additional, Clementi, L. N., additional, Forlini, M., additional, Lando, L., additional, Pezzuoli, M. L., additional, Corradetti, P., additional, Leurent, G., additional, Pennec, P. Y., additional, Filippi, E., additional, Moquet, B., additional, Hacot, J. 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M., additional, Pineda, J., additional, Bordes, P., additional, Quintanilla, M., additional, Mainar, V., additional, Sogorb, F., additional, Santos, N., additional, Serrao, M., additional, Cafe, H., additional, Silva, B., additional, Oliveira, R., additional, Caires, G., additional, Drumond, A., additional, Araujo, J., additional, Providencia, R. A., additional, Gomes, P. L., additional, Pais, J. R., additional, Mota, P., additional, Leitao-Marques, A. M., additional, Farhan, S., additional, Jarai, R., additional, Tentzeris, I., additional, Vogel, B., additional, Freynhofer, M. K., additional, Wojta, J., additional, Huber, K., additional, Poli, M., additional, Trambaiolo, P., additional, Corsi, F., additional, De Luca, M., additional, Mustilli, M., additional, Lukic, V., additional, Simonetti, M., additional, Ferraiuolo, G., additional, Lettino, M., additional, Casella, G., additional, Conte, M. R., additional, De Luca, L., additional, Geraci, G., additional, Ceravolo, R., additional, Pani, A., additional, Fradella, G., additional, Schratter, A., additional, Thiele, H., additional, Klemm, T., additional, Demmin, K., additional, Lehmann, D., additional, Mende, M., additional, Schuler, G., additional, Pittl, U., additional, Chernova, A., additional, Nikulina, S. U., additional, Naruke, T., additional, Inomata, T., additional, Yanagisawa, T., additional, Maekawa, E., additional, Mizutani, T., additional, Shinagawa, H., additional, Nishii, M., additional, Takeuchi, I., additional, Takehana, H., additional, Izumi, T., additional, Paulo, C., additional, Mascarenhas, J., additional, Patacho, M., additional, Pimenta, J., additional, Bettencourt, P., additional, Nardai, S., additional, Szabo, G. Y., additional, Berta, B., additional, Edes, I., additional, Merkely, B., additional, Delgado Silva, J., additional, Baptista, R., additional, Faria, R., additional, Trigo, J., additional, Gago, P., additional, Gheorghe, G., additional, Nanea, I. T., additional, Cristea, A., additional, Almarichi, S., additional, Martins, H., additional, Saraiva, F., additional, Jorge, E., additional, Mendes, P. L., additional, Monteiro, P., additional, Costa, S., additional, Franco, F., additional, Providencia, L. A., additional, Nanea, T., additional, Gheorghe, G. S., additional, Visan, S., additional, Paun, N., additional, Gaber, R., additional, Delewi, R., additional, Nijveldt, R., additional, De Bruin, H. A., additional, Hirsch, A., additional, Van Der Laan, A., additional, Bouma, B. J., additional, Tijssen, J. P. G., additional, Van Rossum, A. C., additional, Zijlstra, F., additional, Piek, J. J., additional, Rus, H., additional, Donea, M., additional, Ciurea, C., additional, Ifteni, G., additional, Casolo, G., additional, Chioccioli, M., additional, Magnacca, M., additional, Del Meglio, J., additional, Comella, A., additional, Baratto, M., additional, Lera, J., additional, Salvadori, L., additional, Tessa, C., additional, Vignali, C., additional, Keca, Z., additional, Momcilov Popin, T., additional, Panic, G., additional, White, R., additional, Mateen, F., additional, Weaver, A., additional, Agmon, Y., additional, Okisheva, E., additional, Tsaregorodtsev, D., additional, Sulimov, V., additional, Amat Santos, I. J., additional, Hernandez, C., additional, Tapia, C., additional, Campo, A., additional, Fredman, D., additional, Svensson, L., additional, Rosenqvist, M., additional, Tadel-Kocjancic, S., additional, Radsel, P., additional, Knafelj, R., additional, Gorjup, V., additional, Noc, M., additional, Zima, E., additional, Jenei, Z. S., additional, Kovacs, E., additional, Osztheimer, I., additional, Molnar, L., additional, Horvath, A., additional, Becker, D., additional, Geller, L., additional, Maggi, R., additional, Furukawa, T., additional, Viscardi, V., additional, Brignole, M., additional, Leal, S. R. N., additional, Dores, H., additional, Rosario, I., additional, Monge, J., additional, Carvalho, M. J., additional, Arroja, I., additional, Leitao, A., additional, Fonseca, C., additional, Aleixo, A., additional, Silva, A., additional, Keuleers, S., additional, Herijgers, P., additional, Herregods, M. C., additional, Budts, W., additional, Dubois, C., additional, Meuris, B., additional, Verhamme, P., additional, Flameng, W., additional, Van De Werf, F., additional, Adriaenssens, T., additional, Badran, H., additional, Elnoamany, M., additional, Lolah, T., additional, Olariu, C., additional, Macarie, C., additional, Mollik, M. A. H., additional, Hassan, A. I., additional, Paul, T. K., additional, Haque, M. Z., additional, Jahan, R., additional, Rahmatullah, M., additional, Khatun, M. A., additional, Rahman, M. T., additional, Chowdhury, M. H., additional, Bustamante Munguira, J., additional, Tamayo, E., additional, Garcia-Cuenca, I., additional, Bustamante, E., additional, Gualis, J., additional, Gomez-Martinez, M. L., additional, Florez, S., additional, Gomez-Herreras, J. I., additional, Ramirez Rodriguez, R., additional, Ramirez Rodriguez, A. M., additional, Garcia-Bello, M. A., additional, Hernadez Ortega, E., additional, Caballero Dorta, E., additional, Garcia Quintana, A., additional, Piro Mastraccio, V., additional, Medina Fernandez Aceytuno, A., additional, Assanelli, E., additional, De Metrio, M., additional, Rubino, M., additional, Lauri, G., additional, Cabiati, A., additional, Campodonico, J., additional, Grazi, M., additional, Moltrasio, M., additional, Marana, I., additional, Marenzi, G., additional, Lovlien, M., additional, Schei, B., additional, Picon-Heras, R., additional, Acebal, C., additional, Garcia Rubira, J. C., additional, Vivas Balcones, D., additional, Nunez-Gil, I., additional, Ruiz-Mateos, B., additional, Ibanez, B., additional, Fernandez-Ortiz, A., additional, Vintila, V. D., additional, Enescu, O. A., additional, Stoicescu, C. I., additional, Udroiu, C., additional, Cinteza, M., additional, Tatu - Chitoiu, G., additional, Vinereanu, D., additional, Fresco, C., additional, De Biasio, M., additional, Muser, D., additional, Sappa, R., additional, Morocutti, G., additional, Bernardi, G., additional, Proclemer, A., additional, Fontanella, B., additional, Affatato, A., additional, Ciccarese, C., additional, Sacchini, M., additional, Volpini, M., additional, Bianchetti, F., additional, Verzura, G., additional, Dei Cas, L., additional, Pudil, R., additional, Blaha, V., additional, Vojacek, J., additional, Paraskevaidis, I., additional, Ikonomidis, I., additional, Parissis, J., additional, Papadopoulos, C., additional, Stasinos, V., additional, Bistola, V., additional, Anastasiou-Nana, M., additional, Shochat, M., additional, Shotan, A., additional, Kazatsker, M., additional, Gurovich, V., additional, Asif, A., additional, Noiman, E., additional, Levy, Y., additional, Blondhaim, D., additional, Rabinovich, P., additional, Meisel, S., additional, Petrovic, S., additional, Glasnovic, J., additional, Tomasevic, M., additional, Sakac, D., additional, Obradovic, S., additional, Londono Sanchez, O., additional, Pacreu, S., additional, Torres, L., additional, Mihaylov, G., additional, Shaban, G. M., additional, Trendafilova, E., additional, Krasteva, V., additional, Mudrov, T. S., additional, Didon, J. P., additional, Panageas, V., additional, Vlachos, N., additional, Pernat, A., additional, Radan, I., additional, Mozina, H., additional, Pepi, P., additional, Cionini, F., additional, Baccaglioni, N., additional, Viertel, A., additional, Havers, J., additional, Ballard, G., additional, Groenefeld, G., additional, Branco, L. 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S., additional, Velinov, H., additional, Velchev, V., additional, Hazarbasanov, D., additional, Apostolova, M., additional, Finkov, B., additional, Petrovic, M., additional, Jovelic, A., additional, Canji, T., additional, Srdanovic, I., additional, Popov, T., additional, Golubovic, M., additional, Pavlovic, K., additional, Cemerlic-Adjic, N., additional, Bro-Jeppesen, J., additional, Kjaergaard, J., additional, Wanscher, M. C., additional, Nielsen, S. L., additional, Rasmussen, L. S., additional, Hassager, C., additional, Khan, M., additional, Crolla, E., additional, Morley, H., additional, Akeroyd, L., additional, Beaini, Y., additional, Morley, C., additional, Bekeredjian, R. H., additional, Krumsdorf, U., additional, Rottbauer, W., additional, Katus, H. A., additional, Pleger, S., additional, Botelho, A., additional, Quintal, N., additional, Faria, P., additional, Gomes, S., additional, Roussel, J. C., additional, Senage, T., additional, Perigaud, C., additional, Habash, O., additional, Michel, M., additional, Treilhaud, M., additional, Despins, P., additional, Trochu, J. N., additional, Baron, O., additional, Duveau, D., additional, Kitsiou, A. N., additional, Giannakopoulos, K., additional, Papadimitriou, G., additional, Karas, S., additional, Babic, Z., additional, Nikolic Heitzler, V., additional, Milicic, D., additional, Bergovec, M., additional, Raguz, M., additional, Mirat, J., additional, Strozzi, M., additional, Plazonic, Z., additional, Giunio, L., additional, Steiner, R., additional, Freynhofer, M., additional, Brozovic, I., additional, Bruno, V., additional, Leherbauer, L., additional, Djurkovic, M., additional, Willheim, M., additional, Huebl, W., additional, Hahne, S., additional, Kozanli, I., additional, Kalla, K., additional, Geppert, A., additional, Unger, G., additional, Simoes Marques Assuncao Caetano, A. 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A., additional, Paarup Dridi, N., additional, Holmvang, L., additional, Engstroem, T., additional, Rekik, S., additional, Brunet, J., additional, Hager, F. X., additional, Bayet, G., additional, Meille, L., additional, Quatre, J. M., additional, Sainsous, J., additional, Chu, P.- H., additional, Tang, C.- H., additional, Pogosova, N., additional, Koltunov, I. E., additional, Sapunova, I. D., additional, Vigodin, V. A., additional, Uhliar, R., additional, Schmidt, A., additional, Brockmeyer, B., additional, Suzuki, A., additional, Eki, Y., additional, Higuchi, H., additional, Yukawa, A., additional, Yamauchi, R., additional, Sato, Y., additional, Endo, Y., additional, Salazar Mendigucha Garcia, J., additional, Homs Vila, S., additional, Cequier Fillat, A., additional, Andion Ogando, R., additional, Sandin Fuentes, M., additional, Vegas Valle, J. M., additional, Gonzalez Garcia, I. A., additional, Duro Aguado, I. A., additional, Palomino Doza, A. J., additional, Gomez Salvador, I., additional, San Roman Calvar, J. A., additional, Mamarasulov, T. M., additional, Todorovic, L., additional, Cherneva, Z. C. H., additional, Denchev, S. D., additional, Heltai, K., additional, Boytsov, A., additional, Nikulina, N. N., additional, Zanna, D., additional, Marangelli, V., additional, Caiati, C., additional, Picon Heras, R., additional, Loureiro, M. J., additional, Urazovskaya, I., additional, Vinogradova, D., additional, Vasilieva, E., additional, Shpektor, A., additional, Conti, E., additional, Musumeci, M. B., additional, Lauri, F. 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V., additional, Galkina, J. V., additional, Timofeev, A. V., additional, Vorobyov, R. I., additional, Vorobyova, E. N., additional, Matos, L., additional, Carvalho, A. C. C., additional, Oliveira, W., additional, Cintra, F., additional, Poyares, D., additional, Andersen, M., additional, Martins, R., additional, Tufik, S., additional, Ostadal, P., additional, Brada, J., additional, Horakova, S., additional, Mlcek, M., additional, Hrachovina, V., additional, Kittnar, O., additional, Gorudko, I. V., additional, Buko, I. V., additional, Cherenkevich, S. N., additional, Polonetsky, L. Z., additional, Plotkin, V. Y., additional, Timoshina, M. A., additional, Azanchevskaya, S. V., additional, Chromov-Borisov, N. N., additional, Vorlat, A., additional, Snoep, L., additional, Claeys, M. J., additional, Vrints, C. J., additional, Palazzuoli, A., additional, Caputo, M., additional, Quatrini, I., additional, Calabro, A., additional, Antonelli, G., additional, Campagna, M. 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A., additional, Adgey, J. A. A., additional, Caeiro Pereira, D., additional, Braga, P., additional, Fontes Carvalho, R., additional, Rodrigues, A., additional, Goncalves, M., additional, Simoes, L., additional, and Borisov, K. V., additional

Published
2010
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39. The Diagnosis of Acute Myocarditis in Emergency (DAME) score: improving diagnostics within the emergency department

Author

Biagio Solarino, Gianfranco Sinagra, Pasquale Caldarola, Marco Matteo Ciccone, Francesco Massari, Fabio Manca, Lorenzo Grazioli Gauthier, Pietro Scicchitano, Carlo D'Agostino, Francesco Chiarella, Scicchitano, P., Grazioli Gauthier, L., D'Agostino, C., Caldarola, P., Solarino, B., Massari, F., Chiarella, F., Sinagra, G., Manca, F., and Ciccone, M. M.

Subjects
Adult, Chest Pain, medicine.medical_specialty, Myocarditis, Myocarditi, 030204 cardiovascular system & hematology, Chest pain, Hospital, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Retrospective Studie, Internal medicine, Diagnosis, Internal Medicine, medicine, Humans, 030212 general & internal medicine, Retrospective Studies, Emergency Service, Ejection fraction, medicine.diagnostic_test, biology, Emergency department, business.industry, Medical record, Score, Retrospective cohort study, Middle Aged, medicine.disease, Troponin, Emergency Service, Hospital, ROC Curve, Erythrocyte sedimentation rate, biology.protein, medicine.symptom, business, Diagnosi, Human
Abstract

Purpose:. The final diagnosis of myocarditis is challenging. The aim of our study was to provide the D.A.M.E. (Diagnosis of Acute Myocarditis in Emergency) Score for the fast identification of patients suffering from myocarditis at Emergency Department (ED). Methods:. This was a multicenter, retrospective study involving three centers. All medical records from January 2010 to December 2014 reporting a final discharge diagnosis of myocarditis were considered. One hundred-four patients (mean age: 40.2±16.5 years) were enrolled. Clinical, biochemical and instrumental data were gathered. Data were analysed by means of logistic regression model and factorial analysis. A validation cohort from a fourth center was enrolled. Results:. The final determinants of the DAME score were six: fever, chest pain, erythrocyte sedimentation rate (ESR) > 20 mm/h, C-reactive protein (hs-CRP) >3 mg/L, troponin serum levels >3 ng/L, and left ventricle ejection fraction < 50%. All of them received a specified score ranging from 0 to 4. A score > 4 was related to 75% probability of myocarditis; a final score ranging between 1 and 4 was related to 57% probability of myocarditis. ROC curve on the validation cohort (289 patients, 27 with myocarditis) demonstrated the best cut-off to be 7: AUC 0.958 (p< 0.001), sensibility: 100%, specificity: 85.11%, PPV: 40.9%, NPV: 100% (LR+: 6.72; LR-: 0.00). Logistic regression analysis revealed Odds Ratio equal to 2.83 (95% CI 1.90 – 4.20, p < 0.0001). Conclusions:. DAME score can offer a reliable tool in ED setting for the evaluation of patients suffering from suspected myocarditis.

Published
2021

40. Biomechanical and neuroautonomic adaptation to acute blood volume displacement in ischemic dilated cardiomyopathy: the predictive value of the CD25 test

Author

Tommaso Lonobile, Gerardo Casucci, Domenico Acanfora, Roberto Maestri, Pietro Scicchitano, Marco Matteo Ciccone, Claudio Pedone, Raffaele Antonelli Incalzi, Luigi Chiariello, Maria Nolano, Vincenzo Provitera, Acanfora, D., Casucci, G., Ciccone, M. M., Scicchitano, P., Lonobile, T., Chiariello, L., Maestri, R., Pedone, C., Provitera, V., Nolano, M., and Incalzi, R. A.

Subjects
Cardiomyopathy, Dilated, medicine.medical_specialty, Physiology, Blood volume, 030204 cardiovascular system & hematology, Ventricular Function, Left, 03 medical and health sciences, Basal (phylogenetics), 0302 clinical medicine, Heart Rate, Tilt-Table Test, Physiology (medical), Internal medicine, medicine, Humans, Autonomic nervous system, Displacement (orthopedic surgery), Ischemic heart failure, Blood Volume, VEST, business.industry, Stroke Volume, Dilated cardiomyopathy, medicine.disease, Adaptation, Physiological, Predictive value, Biomechanical adaptation, Heart failure, Cardiology, Head-up tilt testing, business, 030217 neurology & neurosurgery
Abstract

We aimed to examine biomechanical and neuroautonomic adaptation to blood volume displacement induced by tilt test in patients with previous inferoapical/inferolateral (IA-IL) or basal/apical septal (BS-AS) myocardial infarction (MI). Twenty-four patients with heart failure (HF) and previous IA-IL MI and 30 patients with HF and previous BS-AS MI were enrolled. All patients underwent head-up tilt test, radionuclide ventricular function monitoring (VEST), sympathovagal balance evaluation, and chronotropic 25-dose isoproterenol infusion test (CD25). Physiopathological reactions to stress-tests were assessed in both groups. Follow-up lasted 36 mo. IA-IL patients showed lower stroke volume (SV), cardiac output (CO), and left ventricle ejection fraction (LVEF) compared with BS-AS. End-diastolic volume decreased in IA-IL group (F = 3.1, P = 0.043) more than in BS-AS group during tilt test. The time trend of end-systolic volume, SV, CO, LVEF, and peak filling rate were similar in the two groups. Norepinephrine (IA-IL supine→tilting 499.5 (SD:28.8)→719.3 (SD:41.5) pg/mL vs. BS-AS supine→tilting 533.9 (SD:33.3)→768.8 (SD:47.9) pg/mL; P < 0.001) and epinephrine plasma concentrations (IA-IL supine→ tilting 125.7 (SD:9.8)→193.7 (SD:9.6) pg/mL vs. BS-AS supine→ tilting 118.8 (SD:8.9)→191.7 (SD:10.2) pg/mL; P < 0.001) increased in both groups. Low-to-high frequencies ratio significantly increased in IA-IL and decreased in BS-AS patients. CD25 was similar in IA-IL and BS-AS patients (IA-IL = 4.6 (SD:0.94), BS-AS = 5.0 (SD:1.06) mg; P = 0.79). CD25 predicted all-cause mortality (hazard ratio 1.48, 95% confidence interval 1.32–1.67; P < 0.0001) after adjusting for age/heart rate. In conclusion, patients with ischemic HF show abnormal biomechanical adaptation to volume displacement and compensatory sympathetic overdrive. The association of reduced b-adrenergic sensitivity and sympathetic denervation in such patients warrants for careful therapeutic choices. NEW & NOTEWORTHY The adaptation to volume displacement induced by tilt test was assessed in patients with heart failure and previous inferoapical/inferolateral or basal/apical septal myocardial infarction. The responsiveness of cardiac muscle to sympathetic nervous system stimulation predicts the mortality in patients with ischemic heart failure and may represent a useful tool for clinicians in the general assessment of this kind of patients.

Published
2020

41. Italian Society of Cardiology-Italian Society of Nephrology Consensus Document: The cardio-renal interaction in the prevention and treatment of cardiovascular diseases - Part I: From cardiovascular risk factors to the mechanisms of cardio-renal damage

Author

Messa, Piergiorgio, Barillà, Francesco, Basile, Christian, Basso, Cristina, Cantaluppi, Vincenzo, Capasso, Giovambattista, Ciccone, Marco Matteo, Contessi, Stefano, Curcio, Antonio, De Nicola, Luca, Esposito, Ciro, Imeraj, Amantia, Lecis, Dalgisio, Mancone, Massimo, Marengo, Marita, Mercuro, Giuseppe, Merlo, Marco, Metra, Marco, Adamo, Marianna, Muscoli, Saverio, Nodari, Savina, Pagura, Linda, Paoletti, Ernesto, Paolillo, Stefania, Pedrinelli, Roberto, Filardi, Pasquale Perrone, Pertosa, Giovanni Battista, Pezzato, Andrea, Pontremoli, Roberto, Romeo, Francesco, Ruggenenti, Piero, Ronco, Claudio, Santoro, Antonio, Sinagra, Gianfranco, Spaccarotella, Carmen, Zippo, Dauphine, Zoccali, Carmine, Indolfi, Ciro, Messa, P., Barilla, F., Basile, C., Basso, C., Cantaluppi, V., Capasso, G., Ciccone, M. M., Contessi, S., Curcio, A., De Nicola, L., Esposito, C., Imeraj, A., Lecis, D., Mancone, M., Marengo, M., Mercuro, G., Merlo, M., Metra, M., Adamo, M., Muscoli, S., Nodari, S., Pagura, L., Paoletti, E., Paolillo, S., Pedrinelli, R., Filardi, P. P., Pertosa, G. B., Pezzato, A., Pontremoli, R., Romeo, F., Ruggenenti, P., Ronco, C., Santoro, A., Sinagra, G., Spaccarotella, C., Zippo, D., Zoccali, C., Indolfi, C., Messa, Piergiorgio, Barillà, Francesco, Basile, Christian, Basso, Cristina, Cantaluppi, Vincenzo, Capasso, Giovambattista, Ciccone, Marco Matteo, Contessi, Stefano, Curcio, Antonio, De Nicola, Luca, Esposito, Ciro, Imeraj, Amantia, Lecis, Dalgisio, Mancone, Massimo, Marengo, Marita, Mercuro, Giuseppe, Merlo, Marco, Metra, Marco, Adamo, Marianna, Muscoli, Saverio, Nodari, Savina, Pagura, Linda, Paoletti, Ernesto, Paolillo, Stefania, Pedrinelli, Roberto, Filardi, Pasquale Perrone, Pertosa, Giovanni Battista, Pezzato, Andrea, Pontremoli, Roberto, Romeo, Francesco, Ruggenenti, Piero, Ronco, Claudio, Santoro, Antonio, Sinagra, Gianfranco, Spaccarotella, Carmen, Zippo, Dauphine, Zoccali, Carmine, and Indolfi, Ciro

Subjects
Arterial hypertension, Diabetes mellitu, Consensus, Cardio-Renal Syndrome, Cardiology, Cardiovascular risk, Dyslipidemia, Heart Disease Risk Factors, Risk Factors, Cardiovascular Diseases, Nephrology, Chronic kidney disease, Humans, Renal Insufficiency, Renal Insufficiency, Chronic, Chronic
Abstract

Chronic kidney disease (CKD) and cardiovascular (CV) disease are highly prevalent conditions in the general population and are strictly connected to each other with a bidirectional interaction. In patients affected by CKD, the leading cause of morbidity and mortality is represented by CV disease, since CKD promotes the atherosclerotic process increasing inflammation, and modifying lipid and bone mineral metabolism. On the other side, a strict relationship exists between CKD and CV risk factors, which are prevalent in nephropathic patients and impose a stringent assessment of the risk of CV events in this population together with an optimized pharmacological approach, complicated by the coexistence of the two pathological conditions. The first part of this consensus document focuses on the mechanisms of cardio-renal damage and on the impact, as well as the management, of the main CV risk factors in the context of CKD.

Published
2022

42. Italian Society of Cardiology (SIC) Position paper: Technical, instrumental and standards of interpretation for electrocardiography, ambulatory electrocardiographic and blood pressure monitoring in telemedicine

Author

Antonio, Curcio, Carmen, Spaccarotella, Natale Daniele, Brunetti, Giuseppe, Molinari, Stefano, Carugo, Cristina, Basso, Marco Matteo, Ciccone, Pasquale Perrone, Filardi, Massimo, Mancone, Giuseppe, Mercuro, Saverio, Muscoli, Savina, Nodari, Roberto, Pedrinelli, Francesco, Barillà, Gianfranco, Sinagra, Ciro, Indolfi, Curcio, A., Spaccarotella, C., Brunetti, N. D., Molinari, G., Carugo, S., Basso, C., Ciccone, M. M., Filardi, P. P., Mancone, M., Mercuro, G., Muscoli, S., Nodari, S., Pedrinelli, R., Barilla, F., Sinagra, G., and Indolfi, C.

Subjects
ECG signal acquisition and analysis, Pandemic, ECG, SARS-CoV-2, Holter, Cardiology, COVID-19, Blood Pressure, Blood Pressure Monitoring, Ambulatory, Ambulatory blood pressure monitoring, Cardiovascular diseases, Remote monitoring, Telemedicine, Electrocardiography, Blood Pressure Monitoring, Ambulatory, Electrocardiography, Ambulatory, Humans, Pandemics, Human
Abstract

The current COVID-19 pandemic has renewed interest in providing healthcare services based on the implementation of innovative technologies. Such strategy capillarizes the therapeutic opportunities for larger urban areas, mostly when people are living under extraordinarily difficult circumstances. Improving care delivery in cardiovascular diseases appears particularly feasible when telemedicine is pursued, especially with regard to baseline standard 12-lead electrocardiography, ambulatory electrocardiographic monitoring, and 24-hour ambulatory blood pressure monitoring. Nowadays, these first-line cardiovascular examinations are also available in health centers and pharmacies, and in recent months, there has been an increasing demand of such local services in the absence of specific rules and regulations regarding technical requirements and standards of interpretation that ensure a high quality clinical consultation.The purpose of this position paper is to provide critical requirements for the type/model of devices to be used, training dedicated to healthcare personnel, ensuring security of sensitive data, highlighting type of platforms to be used, as well as for maintaining high reporting quality and standards.

Published
2021

43. [Myocarditis and pericarditis following mRNA COVID-19 vaccination. Expert opinion of the Italian Society of Cardiology]

Author

Gianfranco, Sinagra, Aldostefano, Porcari, Marco, Merlo, Francesco, Barillà, Cristina, Basso, Marco Matteo, Ciccone, Antonio, Curcio, Massimo, Mancone, Giuseppe, Mercuro, Saverio, Muscoli, Savina, Nodari, Roberto, Pedrinelli, Carmen, Spaccarotella, Pasquale Perrone, Filardi, Ciro, Indolfi, Sinagra, G., Porcari, A., Merlo, M., Barilla, F., Basso, C., Ciccone, M. M., Curcio, A., Mancone, M., Mercuro, G., Muscoli, S., Nodari, S., Pedrinelli, R., Spaccarotella, C., Filardi, P. P., and Indolfi, C.

Subjects
COVID-19 Vaccines, Coronavirus, Epidemiology, Myocarditis, Vaccine, SARS-CoV-2, COVID-19 Vaccine, Messenger, Vaccination, Myocarditi, Cardiology, COVID-19, BNT162 Vaccine, Expert Testimony, Humans, Italy, RNA, Messenger, Pericarditis, RNA, Human
Abstract

The coronavirus disease (COVID-19) pandemic has caused 2.69 million deaths and 122 million infections. Great efforts have been made worldwide to promptly develop effective vaccines and reduce morbidity and mortality rates from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Available vaccines have proven highly effective at preventing symptomatic disease in clinical trials and real-world reports and are playing an essential role in flattening the epidemiology curve and, mostly, in reducing COVID-19 hospitalizations. Some concerns have been raised after very rare cases of myocarditis and pericarditis recently reported by the Centers for Disease Control and Prevention (CDC) as potentially associated with COVID-19 mRNA vaccinations, namely the Pfizer-BioNTech mRNA vaccine (BNT162b2) and the Moderna mRNA vaccine (mRNA-1273). Therefore, the aim of this document is to explore the possible link between COVID-19 mRNA vaccination and the development of myocarditis and/or pericarditis by performing a critical analysis of available data and to provide indications for specific subgroups of individuals.

Published
2021

44. Identification of cardiac organ damage in arterial hypertension: insights by echocardiography for a comprehensive assessment

Author

Flavio D'Ascenzi, Sergio Mondillo, Giulia Elena Mandoli, Regina Sorrentino, Anna Vittoria Mattioli, Roberto Pedrinelli, Maurizio Galderisi, Antonello D'Andrea, Roberta Esposito, Maria Lembo, Marco Matteo Ciccone, Riccardo Liga, Pasquale Palmiero, Francesco Bandera, Pietro Scicchitano, Carlotta Sciaccaluga, Vincenzo Evola, Ciro Santoro, Annapaola Zito, Matteo Cameli, Cameli, M., Lembo, M., Sciaccaluga, C., Bandera, F., Ciccone, M. M., D'Andrea, A., D'Ascenzi, F., Esposito, Roberta, Evola, V., Liga, R., Mandoli, G. E., Palmiero, P., Santoro, C., Scicchitano, P., Sorrentino, R., Zito, A., Pedrinelli, R., Mondillo, S., Mattioli, A. V., and Galderisi, M.

Subjects
Aortic valve, medicine.medical_specialty, arterial hypertension, Physiology, Heart Ventricles, Diastole, Hemodynamics, Context (language use), Speckle tracking echocardiography, Regurgitation (circulation), 030204 cardiovascular system & hematology, cardiac organ damage, diastolic dysfunction, echocardiography, left ventricular hypertrophy, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Internal Medicine, Medicine, Humans, 030212 general & internal medicine, Risk factor, business.industry, medicine.disease, Prognosis, Stenosis, medicine.anatomical_structure, Echocardiography, Aortic Valve, Hypertension, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract

Arterial hypertension, a widespread disease, whose prevalence increases with age, represents a major risk factor for cardiovascular events, causing damage in several organs, including the heart. In this context, echocardiography has a clear and pivotal role, being able to assess cardiac morphology and detect haemodynamic changes induced by this disease. 2018 European Society of Cardiology/European Society of Hypertension guidelines on AH identified main echo parameters such as left ventricular mass, relative wall thickness and left atrial volume, for detecting cardiac organ damage. The present review highlights the advantage of additional echocardiographic parameters such as diastolic measurement and both thoracic and abdominal aortic dimensions. An overlook on aortic valve should also be suggested to detect aortic regurgitation and stenosis, both frequent complications in hypertensive patients. In this kind of comprehensive assessment, the combination of standard and advanced echocardiography (speckle tracking echocardiography and, with a lesser extent, three-dimensional echocardiography) could be considered to improve the diagnostic accuracy, stratify prognosis and address management in arterial hypertension.

Published
2020

45. Platelet number is negatively and independently associated with carotid intima-media thickness in apparently healthy overweight/obese subjects.

Author

De Pergola G, Zupo R, Cecere A, Bartolomeo N, Triggiani V, Paradiso S, Lampignano L, Silvestris F, and Ciccone MM

Subjects
Adolescent, Adult, Age Factors, Aged, Biomarkers blood, Blood Pressure, Carotid Artery Diseases diagnostic imaging, Carotid Artery Diseases physiopathology, Female, Humans, Male, Middle Aged, Obesity, Metabolically Benign diagnosis, Obesity, Metabolically Benign physiopathology, Platelet Count, Predictive Value of Tests, Prognosis, Risk Factors, Young Adult, Blood Platelets, Carotid Artery Diseases blood, Carotid Artery, Common diagnostic imaging, Carotid Intima-Media Thickness, Obesity, Metabolically Benign blood, Ultrasonography, Doppler, Color
Abstract

Background and Aim: A significant change of platelet number may be a risk factor for atherosclerotic cardiovascular disease. The aim of this study was to investigate the association between platelet number and early signs of atherosclerosis, evaluated by carotid intima-media thickness (c-IMT), in a apparently healthy population mainly represented by obese subjects., Methods and Results: As many as 961 subjects, 686 women and 275 men, aged between 18 and 74 years, were enrolled in the study. Of these, 54 individuals (5.6% of all subjects) were normal weight, 259 individuals (27.0% of all subjects) were overweight, and 648 individuals (67.4% of all subjects) were obese. Waist circumference (WC) and blood glucose, insulin, total cholesterol, high and low density lipoprotein cholesterol, triglycerides and platelet count were also detected in all subjects, who underwent carotid echo color doppler ultrasound to measure c-IMT. c-IMT was significantly and positively associated to age (r = 0.204, P < 0.0001), fasting glucose (r = 0.073, P < 0.0240), total cholesterol (r = 0.096, P = 0.0031), and systolic and diastolic blood pressure (r = 0.140, P < 0.0001 and r = 0.119, P < 0.0003 respectively); c-IMT was significantly and negatively correlated with platelet count (r = -0.165, P < 0.0001). Only age (P < 0.0001) and systolic blood pressure (P = 0.0393), positively, and platelet number (P < 0.0001), negatively, were significantly and independently associated to c-IMT in a final multiple regression analysis., Conclusion: Lower platelet number represented an independent determinant of c-IMT in a population, mainly represented by obese patients. These results suggest that a decrease of platelet number may well be an early defensive mechanism in subjects developing the thickening of carotid artery., (Copyright © 2018. Published by Elsevier B.V.)

Published
2018
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46. Relationship between Mediterranean diet and asymptomatic peripheral arterial disease in a population of pre-menopausal women.

Author

Mattioli AV, Coppi F, Migaldi M, Scicchitano P, Ciccone MM, and Farinetti A

Subjects
Age Factors, Ankle Brachial Index, Antioxidants administration & dosage, Asymptomatic Diseases, Diet Surveys, Feeding Behavior, Female, Fruit, Health Surveys, Humans, Incidence, Italy, Middle Aged, Nutrition Assessment, Nutritional Status, Nuts, Obesity epidemiology, Obesity prevention & control, Peripheral Arterial Disease diagnosis, Peripheral Arterial Disease epidemiology, Protective Factors, Retrospective Studies, Risk Assessment, Risk Factors, Sex Factors, Vegetables, Diet, Healthy, Diet, Mediterranean, Peripheral Arterial Disease prevention & control, Premenopause, Risk Reduction Behavior
Abstract

Background and Aims: The Mediterranean Diet (MedD) is considered a very healthy diet useful in the prevention of cardiovascular disease. The present study aims to evaluate adherence to MedD in unselected premenopausal women and its relation with ankle-brachial index (ABI), an index of preclinical atherosclerosis., Methods and Results: A group of 425 patients (age range 45-54 years) was investigated. They were enrolled only if they were asymptomatic for cardiovascular disease. Nutritional parameters were assessed by a self-administered food frequency validated questionnaire (116 items) completed by an interviewer administered 24 h diet recall. They all underwent ABI measurement. The mean MedD Score was 32.2 ± 6.1 (Q1-Q3 range 26-37) comparing with data from Italian population (46 ± 8.3) was significantly lower. Intake of food categories sources of antioxidants was higher in patients with a greater adherence to Med D and was mainly related to fruit and vegetables. Patients were categorized in quartile according to MedD Score and we evaluate the distribution of ABI index within quartile. 31.4% of women in Q1 (lower adherence to MedD) had an ABI lower than 0.9 compared to 18.3% of women in Q4 (higher adherence to MedD): p < 0.01. Obesity was more frequent in Q1 compared to Q4 and in women with lower ABI., Conclusions: Women with a low MedD Score were more obese and showed instrumental sign of preclinical peripheral atherosclerosis. MedD rich in antioxidants from fruit, vegetables and nuts influenced the development of atherosclerosis and was associated with a lower incidence of asymptomatic atherosclerosis., (Copyright © 2017 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)

Published
2017
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47. Migration in aorta of left main coronary artery stent.

Author

Ciccone MM, Gesualdo M, De Luca Tupputi Schinosa L, Acquaviva T, and Cortese F

Subjects
Humans, Male, Middle Aged, Prosthesis Failure, Angioplasty, Balloon, Coronary adverse effects, Angioplasty, Balloon, Coronary instrumentation, Aorta diagnostic imaging, Computed Tomography Angiography methods, Coronary Angiography methods, Echocardiography methods, Foreign-Body Migration diagnosis, Foreign-Body Migration diagnostic imaging, Myocardial Infarction therapy, Stents adverse effects
Published
2016
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48. The clinical role of contrast-enhanced ultrasound in the evaluation of renal artery stenosis and diagnostic superiority as compared to traditional echo-color-Doppler flow imaging.

Author

Ciccone MM, Cortese F, Fiorella A, Scicchitano P, Cito F, Quistelli G, Pertosa G, D'Agostino R, Guida P, and Favale S

Subjects
False Negative Reactions, False Positive Reactions, Feasibility Studies, Female, Humans, Injections, Intravenous, Italy, Male, Middle Aged, Predictive Value of Tests, Radiography, Sensitivity and Specificity, Contrast Media administration & dosage, Polysaccharides administration & dosage, Renal Artery diagnostic imaging, Renal Artery Obstruction diagnostic imaging, Ultrasonography, Doppler, Color
Abstract

Aim: The purpose of this study was to investigate the feasibility of contrast-enhanced ultrasound (CEUS) in the evaluation of renal artery stenosis as compared with traditional techniques: echo color Doppler (ECD) investigation and selective angiography .CEUS is a technique based on the injection of an intravascular biocompatible tracer, namely an intravenous contrast galactose microparticle suspension containing microbubbles (Levovist), that has a similar rheology to that of red blood cells, allowing quantification of renal tissue perfusion., Methods: A population of 120 hypertensive patients (82 men, mean age 55) with a systolic abdominal murmur and/or a diagnosis of poly-districtual atherosclerosis was studied by ECD and CEUS (Levovist). Selective angiography was performed in patients with renal artery stenosis demonstrated by one of the two ultrasonographic techniques., Results: Forty of the 120 patients in the study population showed renal artery stenosis at one of the two ultrasound techniques: ECD identified renal artery stenosis in 33 cases and CEUS in 38. Instead, selective angiography had detected renal artery stenosis in 38 patients, the same with renal artery stenosis diagnosed by CEUS. Thus, CEUS sensitivity, specificity and accuracy were similar to those of angiography while six false negatives and two false positives were obtained with ECD., Conclusion: Our results suggest that this renal CEUS is a promising, new, non-invasive method for screening patients with suspected renal artery stenosis. This technique appears to be superior to traditional ECD flow imaging for diagnosing renal artery stenosis and so may be an important aid in cardiovascular diagnostics.

Published
2011

49. Macrophages and mast cells are involved in carotid plaque instability.

Author

Marzullo A, Ciccone MM, Covelli C, Serio G, and Ribatti D

Subjects
Biopsy, Female, Humans, Male, Microvessels pathology, Carotid Arteries pathology, Macrophages pathology, Mast Cells pathology, Plaque, Atherosclerotic pathology
Abstract

The aim of this study was to evaluate the role of macrophages and mast cells and of microvascular density in atherosclerotic plaques collected from 63 consecutive symptomatic and asymptomatic patients undergoing carotid endarterectomy for carotid disease. Results have shown no statistically significant differences between the two groups as concerns: (i) the degree of stenosis; (ii) the extention of the lipidic core; (iii) the thickness of the fibrous cup; (iv) the inflammatory infiltrate; (v) the degree of calcification; (vi) the intraplaque hemorrhage. Otherwise, statistically significant difference was found in microvascular density, in the number of CD68-positive macrophages and tryptase-positive mast cells in plaques from symptomatic patients, as compared to asymptomatic patients. Overall, this study indicate that although advanced symptomatic and asymptomatic carotid plaques present similar histomorphological characteristics, the degree of macrophage and mast cell infiltration and differences in microvascular density could help to discriminate between symptomatic and asymptomatic patients.

Published
2011

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