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3 results on '"Cicinskaite I"'

2. [Hospital-acquired urinary tract infections].

Author

Adukauskiene D, Cicinskaite I, Vitkauskiene A, Macas A, Tamosiūnas R, and Kinderyte A

Subjects
Adult, Age Factors, Aged, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Bacteria drug effects, Bacteria isolation & purification, Bacteriuria diagnosis, Bacteriuria drug therapy, Bacteriuria economics, Bacteriuria epidemiology, Bacteriuria etiology, Bacteriuria microbiology, Bacteriuria physiopathology, Child, Cost-Benefit Analysis, Drug Resistance, Microbial, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Pregnancy, Risk Factors, Sex Factors, Urinary Catheterization adverse effects, Urodynamics, Cross Infection diagnosis, Cross Infection drug therapy, Cross Infection economics, Cross Infection epidemiology, Cross Infection etiology, Cross Infection microbiology, Cross Infection physiopathology, Urinary Tract Infections diagnosis, Urinary Tract Infections drug therapy, Urinary Tract Infections economics, Urinary Tract Infections epidemiology, Urinary Tract Infections etiology, Urinary Tract Infections microbiology, Urinary Tract Infections physiopathology
Abstract

Urinary tract infections are responsible for 40-60% of all hospital-acquired infections. Increased age of patients and comorbid diseases render hospitalized patients more susceptible to infection. Almost 80% of hospital-acquired urinary tract infections are associated with urinary catheters, and only 5-10% of urinary infections are caused by invasive manipulations in the urogenital tract. Pathogens of hospital-acquired urinary tract infections are frequently multi-resistant, and antibiotic therapy can only be successful when the complicating factors are eliminated or urodynamic function is restored. For treatment of complicated hospital-acquired urinary tract infections, the antibiotics must exhibit adequate pharmacodynamic and pharmacokinetic properties: high renal clearance of unmetabolized form with good antimicrobial activity in both acidic and alkaline urine. For selection of empirical treatment of hospital-acquired urinary tract infections, it is necessary to evaluate localization of infection, its severity, possible isolates, and the most frequent pathogens in the department where patient is treated. The best choice for the starting the antimicrobial therapy is the cheapest narrow-spectrum effective antibiotic in the treatment of urinary tract infection until microbiological evaluation of pathogens will be received. Adequate management of urinary tract infections lowers the rate of complications, requirements for antibacterial treatment, selection of multi-resistant isolates and is cost effective.

Published
2006

3. [The new aspects of treatment of severe sepsis and septic shock].

Author

Adukauskiene D, Rimdeika R, Vitkauskiene A, Pilvinis V, and Cicinskaite I

Subjects
APACHE, Adrenal Cortex Hormones administration & dosage, Adrenal Cortex Hormones therapeutic use, Adult, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents therapeutic use, Anti-Infective Agents administration & dosage, Anti-Infective Agents therapeutic use, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Blood Glucose analysis, Blood Transfusion, Cardiotonic Agents administration & dosage, Cardiotonic Agents therapeutic use, Fluid Therapy, Humans, Meta-Analysis as Topic, Protein C therapeutic use, Randomized Controlled Trials as Topic, Recombinant Proteins therapeutic use, Sepsis diagnosis, Sepsis drug therapy, Sepsis mortality, Sepsis physiopathology, Shock, Septic diagnosis, Shock, Septic drug therapy, Shock, Septic mortality, Shock, Septic physiopathology, Time Factors, Vasoconstrictor Agents administration & dosage, Vasoconstrictor Agents therapeutic use, Sepsis therapy, Shock, Septic therapy
Abstract

The mortality rate of infection-induced organ dysfunction or hypoperfusion abnormalities due to severe sepsis and septic shock remains unacceptably high. The adequacy and speed of treatment administered in the first hours after syndrome develops influence outcome. Initial resuscitation, appropriate antimicrobial treatment, selection of optimal control methods, properties of fluid therapy, use of vasopressors and inotropic therapy, proper corticosteroid administration, value of the use of recombinant human activated protein C, and glucose control are the most important points newly evaluated for severe and septic shock management.

Published
2006

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