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134 results on '"Cillo, Clemente"'

5. Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients

Author

Quagliata, Luca, Matter, Matthias S., Piscuoglio, Salvatore, Arabi, Leila, Ruiz, Christian, Procino, Alfredo, Kovac, Michal, Moretti, Francesca, Makowska, Zuzanna, Boldanova, Tujana, Andersen, Jesper B., Hämmerle, Monika, Tornillo, Luigi, Heim, Markus H., Diederichs, Sven, Cillo, Clemente, and Terracciano, Luigi M.

Published
2014
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7. Inflammation may modulate IL-6 and C-reactive protein gene expression in the adipose tissue: the role of IL-6 cell membrane receptor

Author

Memoli, Bruno, Procino, Alfredo, Calabro, Paolo, Esposito, Pasquale, Grandaliano, Giuseppe, Pertosa, Giovanni, Del Prete, Marco, Andreucci, Michele, Di Lillo, Saverio, Ferulano, Giuseppe, Cillo, Clemente, Savastano, Silvia, Colao, Annamaria, and Guida, Brunella

Subjects
Interleukin-6 -- Genetic aspects, Interleukin-6 -- Physiological aspects, C-reactive protein -- Genetic aspects, C-reactive protein -- Physiological aspects, Gene expression -- Research, Inflammation -- Genetic aspects, Inflammation -- Physiological aspects, Inflammation -- Research, Adipose tissues -- Physiological aspects, Adipose tissues -- Genetic aspects, Adipose tissues -- Research, Biological sciences
Abstract

Only few studies have been addressed to the presence and regulation of C-reactive protein (CRP) gene expression in different districts of adipose tissue, and no study has investigated the role of adipose tissue in presence of inflammation. Therefore, the aim of this study was to investigate the inflammatory involvement of either adipose tissue or adipose cells (adipocytes and stromal cells, respectively) in patients with chronic inflammatory disease, focusing on regional adipose tissue CRP gene expression. Eighteen patients with inflammatory disease and 14 healthy controls were enrolled. All subjects underwent specific surgical procedures. Inflamed and noninflamed patients provided samples of subcutaneous and/or omental adipose tissue. All samples were analyzed by RT-PCR and real-time PCR for specific gene expression. In addition, both adipocytes and stromal cells were studied by real-time PCR and immunoprecipitation to evaluate either gene or protein expression of CRP. Our results (real-time PCR) demonstrated a higher gene expression of CRP, IL-6, and both IL-6 membrane receptors in subcutaneous samples of inflamed patients than in healthy controls. Furthermore, in omental fragments of inflamed patients, an enhanced mRNA abundance of the same genes, compared with subcutaneous, was observed. The results obtained at cellular level did not provide evidence of any difference between adipocytes and stromal cell CRP gene expression, whereas immunoprecipitation demonstrated the presence of CRP in inflamed subjects. These results provide first-time evidence of the involvement of adipose tissue in the course of chronic inflammatory diseases, with a different degree of participation of the different adipose tissue districts. interleukin-6; interleukin-6 receptors

Published
2007

9. The HOX gene network in hepatocellular carcinoma

Author

Cillo, Clemente, Schiavo, Giulia, Cantile, Monica, Bihl, Michel P., Sorrentino, Paolo, Carafa, Vincenza, Dʼ Armiento, Maria, Roncalli, Massimo, Sansano, Sebastiano, Vecchione, Raffaela, Tornillo, Luigi, Mori, Lucia, De Libero, Gennaro, Zucman-Rossi, Jessica, and Terracciano, Luigi

Published
2011
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10. HOX D13 expression across 79 tumor tissue types

Author

Cantile, Monica, Franco, Renato, Tschan, Adrienne, Baumhoer, Daniel, Zlobec, Inti, Schiavo, Giulia, Forte, Iris, Bihl, Michel, Liguori, Giuseppina, Botti, Gerardo, Tornillo, Luigi, Karamitopoulou-Diamantis, Eva, Terracciano, Luigi, and Cillo, Clemente

Published
2009
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12. Increased HOX C13 expression in metastatic melanoma progression

Author

Cantile Monica, Scognamiglio Giosuè, Anniciello Annamaria, Farina Marisa, Gentilcore Giusy, Santonastaso Clemente, Fulciniti Franco, Cillo Clemente, Franco Renato, Ascierto Paolo A, and Botti Gerardo

Subjects
HOX genes, Metastases, Melanoma cells, Medicine
Abstract

Abstract Background The process of malignant transformation, progression and metastasis of melanoma is not completely understood. Recently, the microarray technology has been used to survey transcriptional differences that might provide insight into the metastatic process, but the validation of changing gene expression during metastatic transition period is poorly investigated. A large body of literature has been produced on the role of the HOX genes network in tumour evolution, suggesting the involvement of HOX genes in several types of human cancers. Deregulated paralogous group 13 HOX genes expression has been detected in melanoma, cervical cancer and odonthogenic tumors. Among these, Hox C13 is also involved in the expression control of the human keratin genes hHa5 and hHa2, and recently it was identified as a member of human DNA replication complexes. Methods In this study, to investigate HOX C13 expression in melanoma progression, we have compared its expression pattern between naevi, primary melanoma and metastasis. In addition HOXC13 profile pattern of expression has been evaluated in melanoma cell lines. Results Our results show the strong and progressive HOX C13 overexpression in metastatic melanoma tissues and cytological samples compared to nevi and primary melanoma tissues and cells. Conclusions The data presentated in the paper suggest a possible role of HOX C13 in metastatic melanoma switch.

Published
2012
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14. HOX genes and human cancers: a link between development, evolution and pathology

Author

CILLO, CLEMENTE and Cillo, Clemente

Subjects
liver cancer, HOX gene, prostate cancer
Abstract

Prof Cillo described how different combinations of HOX genes are expressed in different types of cancer, and how this may represent a possible diagnostic and prognostic tool. Thus for example HOXA13 is highly expressed in most liver cancers whilst HOXC6 is associated with prostatic cancer.

Published
2007

15. cAMP induced modifications of HOX D gene expression in prostate cells allow the identification of a chromosomal area involved in vivo with neuroendocrine differentiation of human advanced prostate cancers

Author

CANTILE M, KISSLINGER A, CINDOLO L, SCHIAVO G, DANTO' V, FRANCO R, ALTIERI V, GALLO A, VILLACCI A, CILLO, CLEMENTE, Cantile, M, Kisslinger, A, Cindolo, L, Schiavo, G, Danto', V, Franco, R, Altieri, V, Gallo, A, Villacci, A, and Cillo, Clemente

Subjects
HOX genes and prostate cancer
Published
2005

25. Adult human neural crest–derived cells for articular cartilage repair

Author

Pelttari, Karoliina, primary, Pippenger, Benjamin, additional, Mumme, Marcus, additional, Feliciano, Sandra, additional, Scotti, Celeste, additional, Mainil-Varlet, Pierre, additional, Procino, Alfredo, additional, von Rechenberg, Brigitte, additional, Schwamborn, Thomas, additional, Jakob, Marcel, additional, Cillo, Clemente, additional, Barbero, Andrea, additional, and Martin, Ivan, additional

Published
2014
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26. HOX gene expression in normal and neoplastic human kidney

Author

CILLO, CLEMENTE, P. BARBA, G. FRESCHI, G. BUCCIARELLI, M. C. MAGLI AND E. B.O.N.C.I.N.E.L.L.I., Cillo, Clemente, P., Barba, G., Freschi, G., Bucciarelli, and M. C. MAGLI AND E. B. O. N. C. I. N. E. L. L., I.

Published
1992

34. Deregulation of the Hox Gene Network and Cancer.

Author

Papageorgiou, Spyros and Cillo, Clemente

Abstract

Although the Hox genes have been identified as master regulatory genes controlling embryonic development, an alternative view on the role of the Hox gene network suggests that it regulates crucial processes at cellular level in eukaryotic organisms. Our working hypothesis considers the Hox network, at the nuclear cell level, as a decoding system for external inductive signals to activate specific genetic programs. We thus identify a cancer as an anomalous structure growing inside the human body and following, from a cellular and architectural viewpoint, the rules controlling body shape during embryonic development. In this chapter we will describe, according to present data, how the Hox gene network acts in specific types of human solid tumours (breast, prostate, bladder, kidney). Furthermore we identify three research areas potentially able to produce, in the near future, important achievements to increase our understanding of (i) the function of the Hox gene network; (ii) the identification of the HOX target genes; (iii) the molecular basis of human cancers. [ABSTRACT FROM AUTHOR]

Published
2007
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43. <TOGGLE>HOX</TOGGLE> gene network is involved in the transcriptional regulation of in vivo human adipogenesis

Author

Cantile, Monica, Procino, Alfredo, D'armiento, Maria, Cindolo, Luca, and Cillo, Clemente

Abstract

Adipogenesis is regulated by the sequential activation of a series of transcription factors: the C/EBP proteins of type β and δ trigger the process while PPARγ and C/EBPα induce the differentiation from pre-adipocyte to adipocyte, followed by adipo-specific gene expression. A number of observations suggest the involvement of genes controlling embryonal development in adipogenesis. In human thyroid follicular carcinoma, it has been recently identified an oncogenetic fusion protein resulting from the interaction between the isoform PPARγ1 of PPARγ and the homeoprotein encoded by the PAX-8 gene. Recent observations have pointed out that gene expression associated with adipocyte differentiation in vivo and in vitro, although partially overlapping, is actually different. HOX genes make up a network of transcription factors (homeoproteins) controlling embryonal development as well as crucial functions of adult eukaryotic cells. The molecular organization of this network of 39 genes appears to be unique in the genome and probably acts regulating phenotypic cell identity. In the present study we have analyzed the expression of the complete HOX gene network, in vivo, in different deposits of human white adipose tissue and in embryonal brown adipose tissues. Most of the genes in the HOX network are active in white as well as brown adipose tissue. Furthermore HOX genes display a deposit-specific expression in white adipose tissue. Moreover, expression of the paralogous group 4 genes (HOX A4, HOX B4, HOX C4, and HOX D4), together with that of isolated genes in the network, appears to discriminate between white and brown adipose tissue. This data allows us to postulate the involvement of the HOX network in transcriptional regulation of human adipogenesis and to hypothesize on the molecular mechanisms that could be implicated. © 2002 Wiley-Liss, Inc.

Published
2003
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44. Relationship between DNA methylation and gene expression of the HOXBgene cluster in small cell lung cancers

Author

Flagiello, Domenico, Poupon, Marie-France, Cillo, Clemente, Dutrillaux, Bernard, and Malfoy, Bernard

Abstract

The expression pattern of the HOXBgene cluster in four xenografted small-cell lung cancers was compared to the methylation of the DNA in the corresponding genomic regions. In 90% (17/19) of the studied cases, the expressed genes were in methylated regions whereas 70% (12/17) of the unexpressed genes were in unmethylated regions. This specific behavior could correspond to a particular gene expression regulation mechanism of the HOXgene network. Since some genes ( HOXB2, HOXB4, HOXB7) were always inactive when unmethylated, this unexpected relationship might indicate their key function(s) in the HOXgene network.

Published
1996
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