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6 results on '"Cindy Ledesma-de la Cruz"'

1. Consenso de leucemia mieloide aguda en México

Author

Luara L. Arana-Luna, Martha Alvarado-Ibarra, Luis G. Silva-Michel, Adrián Morales-Maravilla, María del C. González-Rubio, Lénica A. Chávez-Aguilar, Ma. Fernanda Tena-Iturralde, Liliana Mojica-Balceras, Nidia Zapata-Canto, Patricia Galindo-Delgado, Ma. Raquel Miranda-Madrazo, Alba E. Morales-Hernández, Karina Silva-Vera, Flavio A. Grimaldo-Gómez, Álvaro Hernández-Caballero, Ramón A. Bates-Martín, José L. Álvarez-Vera, Fredy Tepepa-Flores, Óscar Teomitzi-Sánchez, Denisse J. Fermín-Caminero, José A. de la Peña-Celaya, Óscar Salazar-Ramírez, Luz V. Flores-Villegas, Lidia V. Guerra-Alarcón, Faustino Leyto-Cruz, Sergio I. Inclán-Alarcón, Andrea I. Milán-Salvatierra, Yanet Ventura-Enríquez, Uendy Pérez-Lozano, Pamela E. Báez-Islas, Ana L. Tapia-Enríquez, Orlando G. Palma-Moreno, Jocelyn Aguilar-Luevano, Arturo Espinosa-Partida, Luis F. Pérez-Jacobo, Flavio Rojas-Castillejos, Josué I. Ruiz-Contreras, Sergio J. Loera-Fragoso, Jesús E. Medina-Coral, Brenda L. Acosta-Maldonado, Emely J. Soriano-Mercedes, Erick E. Saucedo-Montes, Luis M. Valero-Saldana, Susana G. González-Prieto, Lorena Nava-Villegas, Ana K. Hernández-Colín, Areli E. Hernández-Alcántara, Pedro A. Zárate-Rodríguez, Gregorio Ignacio-Ibarra, Luis A. Meillón-García, Karla A. Espinosa-Bautista, Cindy Ledesma-de la Cruz, Diego M. Barbosa-Loría, Carolina García-Castillo, Carolina Balderas-Delgado, Álvaro Cabrera-García, Juan M. Pérez-Zúñiga, Eleazar Hernández-Ruiz, Atenas Villela-Peña, Sue Cynthia Gómez Cortés, Hilda Romero-Rodelo, Katheryn B. Garzón-Velásquez, Cristina Serrano-Hernández, Annel Martínez-Ríos, Ma. Luisa Pedraza-Colín, Jorge A. Martínez-Coronel, Iris M. Narváez-Davalos, Alinka S. García-Camacho, Laura E. Merino-Pasaye, Carolina Aguilar-Andrade, Juan A. Aguirre-Domínguez, Pedro G. Guzmán-Mera, Elizabeth Delgado-de la Rosa, Perla E. Flores López, Lilia L. González-Aguirre, Edgar M. Ramírez-Alfaro, Heidi Vera-Calderón, Ma. Lizeth Meza-Dávalos, Juan Murillo-Cruz, Yayra M. Pichardo-Cepín, and Eva F. Ramírez-Romero

Subjects
Public aspects of medicine, RA1-1270, Internal medicine, RC31-1245
Published
2022
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2. Propuesta para manejo de la coagulopatía asociada a la COVID-19 en adultos

Author

Gregorio Ignacio-Ibarra, Ma. Teresa García-Lee, Ana I. González-Ávila, Jaime García-Chávez, Laura Guzmán-Chores, Cindy Ledesma-de la Cruz, Yolanda Lugo-García, Jessi Juárez-Lara, Mauricio García-Vázquez, Cristina E. Madera-Maldonado, Christian Ramos-Peñafiel, and Abraham Majluf-Cruz

Subjects
Public aspects of medicine, RA1-1270, Internal medicine, RC31-1245
Published
2021
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3. Ruxolitinib as a treatment strategy for SARS-CoV-2 pneumonia: clinical experience in a real-world setting

Author

Roberto Ovilla-Martinez, Xochitl Cota-Rangel, Jose De La Peña-Celaya, Mariana Alejandra Alvarado-Zepeda, Alejandro Jiménez Sastré, Humberto Azuara Forcelledo, Bernardino Ordoñez Rodriguez, Juan Pulido Broca, Aaron Molina Jaimes, Alejandro Muñiz-Carvajal, Maria Magdalena Bahena García, Eduardo Cervera Ceballos, Nidia Paulina Zapata Canto, Jorge Oscar García Mendez, Omar Noel García Jímenez, Jesus Alberto Salas Heredia, Javier Solis Soto, Ruben Alberto Villalobos Mendez, Gregorio Ignacio Ibarra, Cindy Ledesma de la Cruz, Nora Araujo Martinez, Jessi Juárez Lara, Cecilio Omar Ceballos Zuñiga, Felipe Vicente Villaseñor Pérez, Jose Carlos Herrera Garcia, Patricia Nuche Salazar, Alfredo Dominguez Paregrina, Bertha Arizpe Bravo, Gabriela Enciso Figueroa, Teresita Trujillo, Adriana Miguel Álvarez, Diego de Jesús García Gallegos, Alejandro Ortiz Arroyo, Claudia Ivette Solorzano Soto, Hiram Javier Jaramillo Ramírez, Ibis De la Cruz Hernández, Sergio De Gante Martínez, Guadalupe Esmeralda Montesinos Gómez, Silvia Martínez Velasco, Roberto García Graullera, Miguel Angel Vázquez López, Victor Itaí Urbalejo Ceniceros, Yolanda Lugo García, Ana Itamar González Ávila, Jorge Duque Rodriguez, Rodolfo Ruiz Luján, Violeta I. Rodríguez Rivera, Lucio Soberanes Ramírez, and Pamela Elena Baez-Islas

Subjects
Cohort Studies, Pyrimidines, Treatment Outcome, Infectious Diseases, SARS-CoV-2, Virology, Nitriles, Humans, Pyrazoles, Parasitology, General Medicine, Microbiology, COVID-19 Drug Treatment
Abstract

Introduction: Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) infection is characterised by a viral phase and a severe pro-inflammatory phase. The inhibition of the JAK/STAT pathway limits the pro-inflammatory state in moderate to severe COVID-19. Methodology: We analysed the data obtained by an observational cohort of patients with SARS-CoV-2 pneumonia treated with ruxolitinib in 22 hospitals of Mexico. The applied dose was determined based on physician’s criteria. The benefit of ruxolitinib was evaluated using the 8-points ordinal scale developed by the NIH in the ACTT1 trial. Duration of hospital stay, changes in pro-inflammatory laboratory values, mortality, and toxicity were also measured. Results: A total of 287 patients were reported at 22 sites in Mexico from March to June 2020; 80.8% received ruxolitinib 5 mg BID and 19.16% received ruxolitinib 10 mg BID plus standard of care. At beginning of treatment, 223 patients were on oxygen support and 59 on invasive ventilation. The percentage of patients on invasive ventilation was 53% in the 10 mg and 13% in the 5 mg cohort. A statistically significant improvement measured as a reduction by 2 points on the 8-point ordinal scale was described (baseline 5.39 ± 0.93, final 3.67± 2.98, p = 0.0001). There were 74 deaths. Serious adverse events were presented in 6.9% of the patients. Conclusions: Ruxolitinib appears to be safe in COVID-19 patients, with clinical benefits observed in terms of decrease in the 8-point ordinal scale and pro-inflammatory state. Further studies must be done to ensure efficacy against mortality.

Published
2022
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4. Consenso de leucemia mieloide aguda en México

Author

Luara L. Arana-Luna, Martha Alvarado-Ibarra, Luis G. Silva-Michel, Adrián Morales-Maravilla, María del C. González-Rubio, Lénica A. Chávez-Aguilar, Ma. Fernanda Tena-Iturralde, Liliana Mojica-Balceras, Nidia Zapata-Canto, Patricia Galindo-Delgado, Ma. Raquel Miranda-Madrazo, Alba E. Morales-Hernández, Karina Silva-Vera, Flavio A. Grimaldo-Gómez, Álvaro Hernández-Caballero, Ramón A. Bates-Martín, José L. Álvarez-Vera, Fredy Tepepa-Flores, Óscar Teomitzi-Sánchez, Denisse J. Fermín-Caminero, José A. de la Peña-Celaya, Óscar Salazar-Ramírez, Luz V. Flores-Villegas, Lidia V. Guerra-Alarcón, Faustino Leyto-Cruz, Sergio I. Inclán-Alarcón, Andrea I. Milán-Salvatierra, Yanet Ventura-Enríquez, Uendy Pérez-Lozano, Pamela E. Báez-Islas, Ana L. Tapia-Enríquez, Orlando G. Palma-Moreno, Jocelyn Aguilar-Luevano, Arturo Espinosa-Partida, Luis F. Pérez-Jacobo, Flavio Rojas-Castillejos, Josué I. Ruiz-Contreras, Sergio J. Loera-Fragoso, Jesús E. Medina-Coral, Brenda L. Acosta-Maldonado, Emely J. Soriano-Mercedes, Erick E. Saucedo-Montes, Luis M. Valero-Saldana, Susana G. González-Prieto, Lorena Nava-Villegas, Ana K. Hernández-Colín, Areli E. Hernández-Alcántara, Pedro A. Zárate-Rodríguez, Gregorio Ignacio-Ibarra, Luis A. Meillón-García, Karla A. Espinosa-Bautista, Cindy Ledesma-de la Cruz, Diego M. Barbosa-Loría, Carolina García-Castillo, Carolina Balderas-Delgado, Álvaro Cabrera-García, Juan M. Pérez-Zúñiga, Eleazar Hernández-Ruiz, Atenas Villela-Peña, Sue Cynthia Gómez Cortés, Hilda Romero-Rodelo, Katheryn B. Garzón-Velásquez, Cristina Serrano-Hernández, Annel Martínez-Ríos, Ma. Luisa Pedraza-Colín, Jorge A. Martínez-Coronel, Iris M. Narváez-Davalos, Alinka S. García-Camacho, Laura E. Merino-Pasaye, Carolina Aguilar-Andrade, Juan A. Aguirre-Domínguez, Pedro G. Guzmán-Mera, Elizabeth Delgado-de la Rosa, Perla E. Flores López, Lilia L. González-Aguirre, Edgar M. Ramírez-Alfaro, Heidi Vera-Calderón, Ma. Lizeth Meza-Dávalos, Juan Murillo-Cruz, Yayra M. Pichardo-Cepín, and Eva F. Ramírez-Romero

Subjects
General Medicine
Published
2023
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5. Consensus in acute myeloid leukemia in Mexico

Author

Luara L. Arana-Luna, Martha Alvarado-Ibarra, Luis G. Silva-Michel, Adrián Morales-Maravilla, María del C. González-Rubio, Lénica A. Chávez-Aguilar, Ma. Fernanda Tena-Iturralde, Liliana Mojica-Balceras, Nidia Zapata-Canto, Patricia Galindo-Delgado, Ma. Raquel Miranda-Madrazo, Alba E. Morales-Hernández, Karina Silva-Vera, Flavio A. Grimaldo-Gómez, Álvaro Hernández-Caballero, Ramón A. Bates-Martín, José L. Álvarez-Vera, Fredy Tepepa-Flores, Óscar Teomitzi-Sánchez, Denisse J. Fermín-Caminero, José A. de la Peña-Celaya, Óscar Salazar-Ramírez, Luz V. Flores-Villegas, Lidia V. Guerra-Alarcón, Faustino Leyto-Cruz, Sergio I. Inclán-Alarcón, Andrea I. Milán-Salvatierra, Yanet Ventura-Enríquez, Uendy Pérez-Lozano, Pamela E. Báez-Islas, Ana L. Tapia-Enríquez, Orlando G. Palma-Moreno, Jocelyn Aguilar-Luevano, Arturo Espinosa-Partida, Luis F. Pérez-Jacobo, Flavio Rojas-Castillejos, Josué I. Ruiz-Contreras, Sergio J. Loera-Fragoso, Jesús E. Medina-Coral, Brenda L. Acosta-Maldonado, Emely J. Soriano-Mercedes, Erick E. Saucedo-Montes, Luis M. Valero-Saldana, Susana G. González-Prieto, Lorena Nava-Villegas, Ana K. Hernández-Colín, Areli E. Hernández-Alcántara, Pedro A. Zárate-Rodríguez, Gregorio Ignacio-Ibarra, Luis A. Meillón-García, Karla A. Espinosa-Bautista, Cindy Ledesma-de la Cruz, Diego M. Barbosa-Loría, Carolina García-Castillo, Carolina Balderas-Delgado, Álvaro Cabrera-García, Juan M. Pérez-Zúñiga, Eleazar Hernández-Ruiz, Atenas Villela-Peña, Sue Cynthia Gómez Cortés, Hilda Romero-Rodelo, Katheryn B. Garzón-Velásquez, Cristina Serrano-Hernández, Annel Martínez-Ríos, Ma. Luisa Pedraza-Colín, Jorge A. Martínez-Coronel, Iris M. Narváez-Davalos, Alinka S. García-Camacho, Laura E. Merino-Pasaye, Carolina Aguilar-Andrade, Juan A. Aguirre-Domínguez, Pedro G. Guzmán-Mera, Elizabeth Delgado-de la Rosa, Perla E. Flores López, Lilia L. González-Aguirre, Edgar M. Ramírez-Alfaro, Heidi Vera-Calderón, Ma. Lizeth Meza-Dávalos, Juan Murillo-Cruz, Yayra M. Pichardo-Cepín, and Eva F. Ramírez-Romero

Subjects
Leukemia, Myeloid, Acute, Consensus, Humans, Cell Differentiation, General Medicine, Mexico
Abstract

Acute myeloid leukemia (AML) comprises a heterogeneous group of hematopoietic cell neoplasms of myeloid lineage that arise from the clonal expansion of their precursors in the bone marrow, interfering with cell differentiation, leading to a syndrome of bone marrow failure. AML is a consequence of genetic and epigenetic changes (point mutations, gene rearrangements, deletions, amplifications, and arrangements in epigenetic changes that influence gene expression) in hematopoietic precursor cells, which create a clone of abnormal cells that are capable of proliferating but cannot differentiate into mature hematopoietic cells or undergo programmed cell death. The diagnosis requires more than 20% myeloid blasts in the bone marrow and certain cytogenic abnormalities. Treatment will depend on age, comorbidities, and cytogenetic risk among the most frequent.La leucemia mieloide aguda (LMA) comprende un grupo heterogéneo de neoplasias de células hematopoyéticas de linaje mieloide que surgen de la expansión clonal de sus precursores en la médula ósea, interfiriendo con la diferenciación celular, lo que conlleva a un síndrome de falla medular. La LMA es una consecuencia de cambios genéticos y epigenéticos (mutaciones puntuales, rearreglos de genes, deleciones, amplificaciones y arreglos en cambios epigenéticos que influyen en la expression del gen) en las células hematopoyéticas precursoras, la cual crea una clona de células anormales que son capaces de proliferar, pero no se pueden diferenciar en células hematopoyéticas maduras ni sufrir una muerte celular programada. El diagnostic requiere más del 20% de blastos mieloides en médula ósea y ciertas anormalidades citogénicas. El tratamiento dependerá de la edad, comorbilidades, riesgo citogenético entre las más frecuentes.

Published
2022

6. A proposal for the management of COVID-19-induced coagulopathy in adults

Author

Mauricio García-Vázquez, Cindy Ledesma-de la Cruz, Jaime García-Chávez, Ma. Teresa García-Lee, Yolanda Lugo-García, Abraham Majluf-Cruz, Laura Guzmán-Chores, Cristina Elizabeth Madera-Maldonado, Christian Omar Ramos-Peñafiel, Jessi Juárez-Lara, Gregorio Ignacio-Ibarra, and Ana Itamar González-Ávila

Subjects
Adult, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Anticoagulants, COVID-19, Guidelines as Topic, General Medicine, Blood Coagulation Disorders, medicine.disease, Anticoagulant therapy, Case fatality rate, Pandemic, medicine, Coagulopathy, Humans, Intensive care medicine, business, Mexico, Algorithms, Cause of death
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is the cause of the coronavirus disease 2019 (COVID-19) pandemic, which has a high case fatality rate. Most severely ill patients develop a special type of coagulopathy that had not been described before and that is now considered the main cause of death. For this reason, anticoagulant treatment has become one of the cornerstones of the treatment of this infection. However, the rate at which the evidence regarding the use of anticoagulants is generated is quite fast, and sometimes it is difficult to interpret and conflicting. After having performed an extensive review of the published literature, this proposal for the use of anticoagulant treatment is made, taking into account available resources in Mexico.La infección por coronavirus 2 del síndrome respiratorio agudo grave (SARS-CoV-2) es la causante de la pandemia de enfermedad por coronavirus 2019 (COVID-19), con un índice de letalidad alto. La mayoría de los pacientes graves desarrollan un tipo especial de coagulopatía no descrito hasta ahora y la cual se considera ahora la principal causa de muerte. Por esta razón, el tratamiento anticoagulante se ha convertido en una de las piedras angulares del tratamiento de esta infección. Sin embargo, la velocidad con la que se genera la evidencia respecto al uso de anticoagulantes es muy rápida y, en ocasiones difícil de interpretar y contradictoria. Luego de hacer una revisión extensa de la literatura publicada, se hace esta propuesta para el uso del tratamiento anticoagulante tomando en cuenta los recursos disponibles en México.

Published
2021
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