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3. Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury: a multicentre, randomised, double-blind, placebo-controlled, assessor-masked superiority trial

Author

DAHYOT-FIZELIER, Claire, LASOCKI, Sigismond, KERFORNE, Thomas, PERRIGAULT, Pierre-Francois, GEERAERTS, Thomas, ASEHNOUNE, Karim, CINOTTI, Raphaël, LAUNEY, Yoann, COTTENCEAU, Vincent, LAFFON, Marc, GAILLARD, Thomas, BOISSON, Matthieu, ALEYRAT, Camille, FRASCA, Denis, MIMOZ, Olivier, GUYONNAUD, Clément, BELLIER, Rémy, BENARD, Thierry, CARISE, Elsa, PETITPAS, Franck, NANADOUMGAR, Hodanou, IMZI, Nadia, SEGUIN, Sabrina, GARNIER, Karine, FERRAND-RIGALLAUD, Véronique, CLERJAUD, Séverine, GERGAUD, Soizic, DJANIKIAN, Flora, CHALARD, Kevin, MROZEK, Ségolène, PANH, Sylvain, ROQUILLY, Antoine, ROZEC, Bertrand, SEGUIN, Philippe, MALLEDANT, Yannick, ELAROUSSI, Djilali, FERRANDIERE, Martine, BIAIS, Matthieu, Dahyot-Fizelier, Claire, Lasocki, Sigismond, Kerforne, Thomas, Perrigault, Pierre-Francois, Geeraerts, Thomas, Asehnoune, Karim, Cinotti, Raphaël, Launey, Yoann, Cottenceau, Vincent, Laffon, Marc, Gaillard, Thomas, Boisson, Matthieu, Aleyrat, Camille, Frasca, Denis, and Mimoz, Olivier

Published
2024
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4. Incidence, Risk Factors, and Long-Term Outcomes for Extubation Failure in ICU in Patients With Obesity: A Retrospective Analysis of a Multicenter Prospective Observational Study

Author

De Jong, Audrey, Capdevila, Mathieu, Aarab, Yassir, Cros, Matthieu, Pensier, Joris, Lakbar, Ines, Monet, Clément, Quintard, Hervé, Cinotti, Raphael, Asehnoune, Karim, Arnal, Jean-Michel, Guitton, Christophe, Paugam-Burtz, Catherine, Abback, Paer, Mekontso-Dessap, Armand, Lakhal, Karim, Lasocki, Sigismond, Plantefeve, Gaetan, Claud, Bernard, Pottecher, Julien, Corne, Philippe, Ichai, Carole, Molinari, Nicolas, Chanques, Gerald, Papazian, Laurent, Azoulay, Elie, and Jaber, Samir

Published
2025
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6. Prospective multi-center evaluation of the incidence of unplanned extubation and its outcomes in French intensive care units. The Safe-ICU study

Author

Guillemin, Jérémie, Rieu, Benjamin, Huet, Olivier, Villeret, Léonie, Pons, Stéphanie, Bignon, Anne, de Roux, Quentin, Cinotti, Raphaël, Legros, Vincent, Plantefeve, Gaëtan, Dayhot-Fizelier, Claire, Omar, Edris, Cadoz, Cyril, Bounes, Fanny, Caplin, Cécile, Toumert, Karim, Martinez, Thibault, Bouvier, Damien, Coutrot, Maxime, Godet, Thomas, Garçon, Pierre, Constantin, Jean-Michel, Assefi, Mona, and Blanchard, Florian

Published
2024
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7. Characteristics and Prognosis Factors of Pneumocystis jirovecii Pneumonia According to Underlying Disease: A Retrospective Multicenter Study

Author

Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Lécuyer, Romain, Asquier-Khati, Antoine, Le Pape, Patrice, Morio, Florent, Lavergne, Rose-Anne, Jeddi, Fakhri, Corvec, Stéphane, Bemer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Leroy, Anne-Gaëlle, Lakhal, Karim, Cinotti, Raphaël, Roquilly, Antoine, Emmanuel Canet, Jean Reignier, Blanc, François Xavier, Bretonniere, Cédric, Morin, Paul, Camou, Fabrice, Issa, Nahéma, Guisset, Olivier, Mourissoux, Gaelle, Accoceberry, Isabelle, Gabriel, Frederic, Coron, Noémie, Delhaes, Laurence, Imbert, Sébastien, Lefranc, Maxime, Lussac-Sorton, Florian, Rougeron, Amandine, Gousseff, Marie, Crabol, Yoann, Corvaisier, Grégory, Lautredoux, Florent, Cady, Anne, Auger, Myriam, Pouedras, Pascal, Lavergne, Rose-anne, Canet, Emmanuel, Raffi, François, Néel, Antoine, Tessoulin, Benoît, and Gaborit, Benjamin

Published
2024
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8. Evaluating the Sum of Eye and Motor Components of the Glasgow Coma Score As a Predictor of Extubation Failure in Patients With Acute Brain Injury

Author

Taran, Shaurya, Perrot, Bastien, Angriman, Federico, Cinotti, Raphael, Abback, Paër-sélim, Codorniu, Anaïs, Citerio, Giuseppe, Ludovica Sala, Vittoria, Astuto, Marinella, Tringali, Eleonora, Alampi, Daniela, Rocco, Monica, Giuseppina Maugeri, Jessica, Bellissima, Agrippino, Filippini, Matteo, Lazzeri, Nicoletta, Cortegiani, Andrea, Ippolito, Mariachiara, Robba, Chiara, Battaglini, Denise, Biston, Patrick, Fathi Al-Gharyani, Mohamed, Chabanne, Russell, ASTIER, Léo, Soyer, Benjamin, Gaugain, Samuel, Zimmerli, Alice, Pietsch, Urs, Filipovic, Miodrag, Brandi, Giovanna, Bicciato, Giulio, Serrano, Ainhoa, Monleon, Berta, van Vliet, Peter, Marcel Gerretsen, Benjamin, Xochitl Ortiz-Macias, Iris, Oto, Jun, Enomoto, Noriya, Matsuda, Tomomichi, Masui, Nobutaka, Garçon, Pierre, Zarka, Jonathan, Vermeijden, Wytze J, Daniel Cornet, Alexander, Reyes Inurrigarro, Sergio, Cirino Lara Domínguez, Rafael, Mercedes Bellini, Maria, Milagros Gomez Haedo, Maria, Lamot, Laura, Orquera, Jose, Biais, Matthieu, Georges, Delphine, Baronia, Arvind, Carlos Miranda-Ackerman, Roberto, José Barbosa-Camacho, Francisco, Porter, John, Lopez-Morales, Miguel, Geeraerts, Thomas, Compagnon, Baptiste, Pérez-Torres, David, Prol-Silva, Estefanía, Basheer Yahya, Hana, Khaled, Ala, Ghula, Mohamed, Neville Andrea, Cracchiolo, Maria Daniela, Palma, Deana, Cristian, Vetrugno, Luigi, Rivera Chavez, Manuel J., Mendoza Trujillo, Rocio, LEGROS, Vincent, Brochet, Benjamin, Huet, Olivier, Geslain, Marie, van der Jagt, Mathieu, van Steenkiste, Job, Ahmed, Hazem, Edward Coombs, Alexander, Welbourne, Jessie, Velarde Pineda, Ana Alicia, Nubert Castillo, VÍctor Hugo, Azab, Mohammed A, Azzam, Ahmed Y, Paul van Meenen, David Michael, Adrian Gasca, Gilberto, Arellano, Alfredo, Galicia-Espinosa, Forttino, Carlos García-Ramos, José, Yadav, Ghanshyam, Kumar Jha, Amarendra, Robert-Edan, Vincent, Rodie-Talbere, Pierre-Andre, Jain, Gaurav, Panda, Sagarika, Agarwal, Sonika, Deewan, Yashbir, Adrian Gasca, Gilberto, Arellano, Alfredo, Tariq Reza, Syed, Hossain, Md. Mozaffer, Papadas, Christos, Chantziara, Vasiliki, Sklavou, Chrysanthi, Hourmant, Yannick, Grillot, Nicolas, van Steenkiste, Job, van der Jagt, Mathieu, Pirracchio, Romain, Akkari, Abdelraouf, Abdelaty, Mohamed, Hashim, Ahmed, Launey, Yoann, Masseret, Elodie, Lasocki, Sigismond, Gergaud, Soizic, Mouclier, Nicolas, Saxena, Sulekha, Agrawal, Avinash, Bedanta Mishra, Shakti, Samal, Samir, Cesar Mijangos, Julio, Haënggi, Mattias, Gurjar, Mohan, Schultz, Marcus J, Kaye, Callum, Agustin Godoy, Daniela, Alvarez, Pablo, Ioakeimidou, Aikaterini, Ueno, Yoshitoyo, Badenes, Rafael, Suei Elbuzidi, Abdurrahmaan Ali, Piagnerelli, Michaël, Elhadi, Muhammed, Tariq Reza, Syed, Atef Azab, Mohammed, Catherine Digitale, Jean, Fong, Nicholas, Campos Cerda, Ricardo, de la Torre Peredo, Norma, Pirracchio, Romain, and David Stevens, Robert

Published
2024
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10. Place de l’analgésie péridurale dans la chirurgie de l’aorte à ciel ouvert en France : étude multicentrique AP2A

Author

Soulé, Christelle, Moussa, Mouhamed, Leviel, Florent, Le Gac, Grégoire, Daccache, Gérard, Le Moal, Charlène, Parigi, Claire, Gouel, Aurélie, Montandrau, Olivier, Joffredo, Jean-Baptiste, Todorova, Violeta, Guerci, Philippe, de Mollien, Louis, Siaudeau, Hélène, Orion, François, Lesvier, Benoit, Mongardon, Nicolas, Maurel, Blandine, Rozec, Bertrand, Brisard, Laurent, and Cinotti, Raphaël

Published
2024
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14. Anxiety and depression symptoms in relatives of moderate-to-severe traumatic brain injury survivors — A multicentre cohort

Author

Cinotti, Raphaël, Chopin, Alice, Moyer, Jean Denis, Huet, Olivier, Lasocki, Sigismond, Cohen, Benjamin, Dahyot-Fizelier, Claire, Chalard, Kevin, Seguin, Philippe, Martin, Florian Pierre, Lerebourg, Céline, Guitteny, Marie, Chenet, Amandine, Perrouin-Verbe, Brigitte, Asehnoune, Karim, Feuillet, Fanny, Sébille, Véronique, and Roquilly, Antoine

Published
2023
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15. Ferric derisomaltose and tranexamic acid, combined or alone, for reducing blood transfusion in patients with hip fracture (the HiFIT trial): a multicentre, 2 × 2 factorial, randomised, double-blind, controlled trial

Author

Bouhours, Guillaume, Lasocki, Sigismond, Lebail, Adeline, Léger, Maxime, Parot-Schinkel, Elsa, Rineau, Emmanuel, Rony, Louis, Vielle, Bruno, Capdevilla, Xavier, Loupec, Thibault, Mounet, Benjamin, Swisser, Fabien, Danguy des Deserts, Marc, Cinotti, Raphael, Grillot, Nicolas, Asehnoune, Karim, Roquilly, Antoine, Beloeil, Hélène, Lahlou-Casulli, Maria, Collange, Vincent, Parent, Sébastien, Delannoy, Bertrand, Desebbe, Olivier, Duchalais, Alexis, Drugeon, Bertrand, Guenezan, Jeremy, Bouzat, Pierre, Drevet, Sabine, Gavazzi, Gaetan, Greze, Jules, Bijok, Benjamin, Garrigue, Delphine, David, Jean-Stéphane, and Capdevila, Xavier

Published
2023
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16. Association of preoperative COVID-19 and postoperative respiratory morbidity during the Omicron epidemic wave: the DROMIS-22 multicentre prospective observational cohort study

Author

Garnier, Marc, Constantin, Jean-Michel, Cinotti, Raphaël, Daoui, Chafia, Leone, Marc, Lapidus, Nathanaël, Hafiani, El Mahdi, Quesnel, Christophe, Imauven, Olivier, Lasocki, Sigismond, Rineau, Emmanuel, Léger, Maxime, Danguy des Deserts, Marc, Schmitt, Johan, Aries, Philippe, Gouel, Aurélie, Voulgaropoulos, Julia, Soldan, Laura, Deransy, Romain, Laurent, Quentin, Gayat, Etienne, Verdonk, Franck, Chaouche, Sabrina, Cambriel, Amélie, Degos, Vincent, Dupont, Julie, Daoud, Laura, Margetis, Dimitri, Salettes, Romain, Favreau, Malory, Noll, Eric, Pottecher, Julien, Diemunsch, Sophie, Abrard, Stanislas, Bidon, Cyril, Roy, Clémence, Destruhaut, Grégory, Ottolenghi, Laëtitia, Edouard, Damien, Lecinq, Agnès, Mercier, Frédéric, Cirenei, Cédric, Garrigue, Delphine, Jozefowicz, Elsa, Pariès, Marie, Espitalier, Fabien, Piat, Charlène, Descamps, Richard, Duchesne, Maëlle, Sigaut, Stéphanie, Thion, Laurie-Anne, Renard, Julie, Brocas, Elsa, Zbidi, Besma, Fki, Mohamed, Quemeneur, Cyril, Dufour, Guillaume, Bucciero, Mario, Rochon, Charles-Edouard, Delerue, Céline, Trehel-Tursis, Virginie, Raft, Julien, Rangeard, Olivier, Thiriet, Claire, Lagarde, Kevin, Pollet, Angélina, Pelen, Félix, Caillard, Anaïs, Penven, Philippe, Huet, Olivier, Puel, Floriane, Pichon, Xavier, Ligneres, Laetitia, Bleuze, Pauline, Deryckere, Stéphanie, Velly, Lionel, Simeone, Pierre, Andrianjatovo, Hery, Chipouline, Youri, Boolad, Mouna, Frasca, Denis, Plouviez, Quentin, Plaud, Benoit, Roland, Eric, Cheron-Leroy, Delphine, Figueiredo, Samy, Blanié, Antonia, Joannes-Boyau, Olivier, Monziols, Simon, Robin, Jean-Jacques, Biais, Matthieu, De Courson, Hugues, Degryse, Cécile, Do-Khac, Marie, Bonnet, Marie-Pierre, Mazeraud, Aurélien, Bardon, Jean, Bouchereau, Eléonore, Pastene, Bruno, Bezulier, Karine, Charbonneau, Hélène, Mrozek, Ségolène, Mayeur, Nicolas, Lopez, Sandrine, and Lecinq, Agnes

Published
2023
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17. Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial.

Author

Taccone, Fabio Silvio, Rynkowski Bittencourt, Carla, Møller, Kirsten, Lormans, Piet, Quintana-Díaz, Manuel, Caricato, Anselmo, Cardoso Ferreira, Marco Antonio, Badenes, Rafael, Kurtz, Pedro, Søndergaard, Christian Baastrup, Colpaert, Kirsten, Petterson, Leticia, Quintard, Herve, Cinotti, Raphael, Gouvêa Bogossian, Elisa, Righy, Cassia, Silva, Serena, Roman-Pognuz, Erik, Vandewaeter, Catherine, and Lemke, Daniel

Subjects
RED blood cell transfusion, BRAIN injuries, BLOOD transfusion, COGNITIVE training, INTENSIVE care units, CLINICAL trials
Abstract

Key Points: Question: How does use of a liberal or restrictive strategy of blood transfusion influence neurological outcome among patients with acute brain injury? Findings: In this randomized clinical trial that included 850 patients with acute brain injury and a hemoglobin level below 9 g/dL, those who were treated with a liberal transfusion strategy triggered by hemoglobin below 9 g/dL had a lower probability of unfavorable neurological outcome at 180 days than those treated with a restrictive strategy triggered by hemoglobin below 7 g/dL (62.6% vs 72.6%, respectively; adjusted relative risk, 0.86). Meaning: A liberal transfusion strategy compared with a restrictive strategy resulted in a lower rate of unfavorable neurological outcome among patients with acute brain injury. Importance: Blood transfusions are commonly administered to patients with acute brain injury. The optimal hemoglobin transfusion threshold is uncertain in this patient population. Objective: To assess the impact on neurological outcome of 2 different hemoglobin thresholds to guide red blood cell transfusions in patients with acute brain injury. Design, Setting, and Participants: Multicenter, phase 3, parallel-group, investigator-initiated, pragmatic, open-label randomized clinical trial conducted in 72 intensive care units across 22 countries. Eligible patients had traumatic brain injury, aneurysmal subarachnoid hemorrhage, or intracerebral hemorrhage; hemoglobin values below 9 g/dL within the first 10 days after injury; and an expected intensive care unit stay of at least 72 hours. Enrollment occurred between September 1, 2017, and December 31, 2022. The last day of follow-up was June 30, 2023. Interventions: Eight hundred fifty patients were randomly assigned to undergo a liberal (transfusion triggered by hemoglobin <9 g/dL; n = 408) or a restrictive (transfusion triggered by hemoglobin <7 g/dL; n = 442) transfusion strategy over a 28-day period. Main Outcomes and Measures: The primary outcome was occurrence of an unfavorable neurological outcome, defined as a Glasgow Outcome Scale Extended score between 1 and 5, at 180 days following randomization. There were 14 prespecified serious adverse events, including occurrence of cerebral ischemia after randomization. Results: Among 820 patients who completed the trial (mean age, 51 years; 376 [45.9%] women), 806 had available data on the primary outcome, 393 in the liberal strategy group and 413 in the restrictive strategy group. The liberal strategy group received a median of 2 (IQR, 1-3) units of blood, and the restrictive strategy group received a median of 0 (IQR, 0-1) units of blood, with an absolute mean difference of 1.0 unit (95% CI, 0.87-1.12 units). At 180 days after randomization, 246 patients (62.6%) in the liberal strategy group had an unfavorable neurological outcome compared with 300 patients (72.6%) in the restrictive strategy group (absolute difference, −10.0% [95% CI, −16.5% to −3.6%]; adjusted relative risk, 0.86 [95% CI, 0.79-0.94]; P =.002). The effect of the transfusion thresholds on neurological outcome at 180 days was consistent across prespecified subgroups. In the liberal strategy group, 35 (8.8%) of 397 patients had at least 1 cerebral ischemic event compared with 57 (13.5%) of 423 in the restrictive strategy group (relative risk, 0.65 [95% CI, 0.44-0.97]). Conclusions and Relevance: Patients with acute brain injury and anemia randomized to a liberal transfusion strategy were less likely to have an unfavorable neurological outcome than those randomized to a restrictive strategy. Trial Registration: ClinicalTrials.gov Identifier: NCT02968654 This randomized clinical trial assesses the effect of a liberal vs a restrictive hemoglobin threshold for red blood cell transfusion on unfavorable neurological outcome in patients with acute brain injury. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Continuous Pneumatic Regulation of Tracheal Cuff Pressure to Decrease Ventilator-associated Pneumonia in Trauma Patients Who Were Mechanically Ventilated: The AGATE Multicenter Randomized Controlled Study

Author

Besch, Guillaume, Bouhemad, Bélaid, Caumon, Elodie, Chamaraux-Tran, Thien-Nga, Cinotti, Raphael, Gaillard, Thomas, Gergaud, Soizic, Ginet, Marc, Gouin, Philippe, Grimaldi, Florian, Guitard, Pierre-Gildas, Hammad, Emmanuelle, Kelesyan, Lilit, Leduc, Sébastien, Leger, Maxime, Ludes, Pierre-Olivier, Muler, Laurent, Nadji, Abdelouaid, Paugam-Burtz, Catherine, Po, Marie-Héléne, Quintard, Hervé, Roger, Claire, Roquilly, Antoine, Marjanovic, Nicolas, Boisson, Matthieu, Asehnoune, Karim, Foucrier, Arnaud, Lasocki, Sigismond, Ichai, Carole, Leone, Marc, Pottecher, Julien, Lefrant, Jean-Yves, Falcon, Dominique, Veber, Benoit, Chabanne, Russell, Drevet, Claire-Marie, Pili-Floury, Sébastien, Dahyot-Fizelier, Claire, Kerforne, Thomas, Seguin, Sabrina, de Keizer, Joe, Frasca, Denis, Guenezan, Jérémy, and Mimoz, Olivier

Published
2021
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20. Association between continuous hyperosmolar therapy and survival in patients with traumatic brain injury - a multicentre prospective cohort study and systematic review.

Author

Asehnoune, Karim, Lasocki, Sigismond, Seguin, Philippe, Geeraerts, Thomas, Perrigault, Pierre François, Dahyot-Fizelier, Claire, Paugam Burtz, Catherine, Cook, Fabrice, Demeure Dit Latte, Dominique, Cinotti, Raphael, Mahe, Pierre Joachim, Fortuit, Camille, Pirracchio, Romain, Feuillet, Fanny, Sébille, Véronique, Roquilly, Antoine, ATLANREA group, and COBI group

Subjects
ATLANREA group, COBI group, Humans, Intracranial Hypertension, Saline Solution, Hypertonic, Tomography, X-Ray Computed, Glasgow Coma Scale, Survival Analysis, Retrospective Studies, Cohort Studies, Prospective Studies, Adult, Middle Aged, Female, Male, Propensity Score, Brain Injuries, Traumatic, Brain oedema, Hyperosmolar therapy, Hypertonic, Intracranial hypertension, Saline solution, Sodium, Trauma, Traumatic brain injury, Saline Solution, Tomography, X-Ray Computed, Brain Injuries, Traumatic, Medical and Health Sciences, Emergency & Critical Care Medicine
Abstract

BackgroundIntracranial hypertension (ICH) is a major cause of death after traumatic brain injury (TBI). Continuous hyperosmolar therapy (CHT) has been proposed for the treatment of ICH, but its effectiveness is controversial. We compared the mortality and outcomes in patients with TBI with ICH treated or not with CHT.MethodsWe included patients with TBI (Glasgow Coma Scale ≤ 12 and trauma-associated lesion on brain computed tomography (CT) scan) from the databases of the prospective multicentre trials Corti-TC, BI-VILI and ATLANREA. CHT consisted of an intravenous infusion of NaCl 20% for 24 hours or more. The primary outcome was the risk of survival at day 90, adjusted for predefined covariates and baseline differences, allowing us to reduce the bias resulting from confounding factors in observational studies. A systematic review was conducted including studies published from 1966 to December 2016.ResultsAmong the 1086 included patients, 545 (51.7%) developed ICH (143 treated and 402 not treated with CHT). In patients with ICH, the relative risk of survival at day 90 with CHT was 1.43 (95% CI, 0.99-2.06, p = 0.05). The adjusted hazard ratio for survival was 1.74 (95% CI, 1.36-2.23, p

Published
2017

21. Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS

Author

Souweine, Bertrand, Eisenmann, Nathanael, Quenot, Jean-Pierre, Seguin, Philippe, Asehnoune, Karim, Lasocki, Sigismond, Ferrandiere, Martine, Sossou, Achile, Langeron, Olivier, Leone, Marc, Dupont, Herve, Veber, Benoit, Ichai, Carole, Rimmelé, Thomas, Legay, François, Grelon, Fabien, Dahyot-Fizelier, Claire, Cayot, Sophie, Godet, Thomas, Guerin, Renaud, Verlhac, Camille, Chabanne, Russell, Cosserant, Bernard, Blondonnet, Raiko, Lautrette, Alexandre, Muller, Laurent, Massanet, Pablo, Boutin, Caroline, Barbar, Saber, Roger, Claire, Belafia, Fouad, Cisse, Moussa, Monnin, Marion, Conseil, Matthieu, Carr, Julie, De Jong, Audrey, Chanques, Gérald, Dargent, Auguste, Crozon, Thomas, Clauzel, Julien, Le Core, Marinne, Andreu, Pascal, Lebouvrier, Thomas, Launey, Yoann, Roquilly, Antoine, Cinotti, Raphael, Tellier, Anne-Charlotte, Barbaz, Mathilde, Cohen, Benjamin, Lemarche, Edouard, Bertrand, Pierre-Marie, Arbelot, Charlotte, Zieleskiewicz, Laurent, Hammad, Emmanuelle, Duclos, Garry, Calypso, Mathieu, Orban, Jean-Christophe, Quintard, Hervé, Assefi, Mona, Morel, Jerome, Molliex, Serge, Petitas, Frank, Nanadougmar, Hadanou, Jabaudon, Matthieu, Audard, Jules, Pereira, Bruno, Jaber, Samir, Lefrant, Jean-Yves, Futier, Emmanuel, Lambert, Céline, Bazin, Jean-Etienne, Bastarache, Julie A., Constantin, Jean-Michel, and Ware, Lorraine B.

Published
2020
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26. Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study

Author

Robba, C, Battaglini, D, Abbas, A, Sarrió, E, Cinotti, R, Asehnoune, K, Taccone, F, Rocco, P, Schultz, M, Citerio, G, Stevens, R, Badenes, R, Abback, P, Codorniu, A, Sala, V, Astuto, M, Tringali, E, Alampi, D, Rocco, M, Maugeri, J, Bellissima, A, Filippini, M, Lazzeri, N, Cortegiani, A, Ippolito, M, Biston, P, Al-Gharyani, M, Chabanne, R, Astier, L, Soyer, B, Gaugain, S, Zimmerli, A, Pietsch, U, Filipovic, M, Brandi, G, Bicciato, G, Serrano, A, Monleon, B, van Vliet, P, Gerretsen, B, Ortiz-Macias, I, Oto, J, Enomoto, N, Matsuda, T, Masui, N, Garçon, P, Zarka, J, Vermeijden, W, Cornet, A, Gard, S, Domínguez, R, Bellini, M, Haedo, M, Lamot, L, Orquera, J, Biais, M, Georges, D, Baronial, A, Miranda-Ackerman, R, Barbosa-Camacho, F, Porter, J, Lopez-Morales, M, Geeraerts, T, Companion, B, Pérez-Torres, D, Prol-Silva, E, Yahya, H, Khaled, A, Ghulam, M, Andrea, C, Daniela, P, Deana, C, Vertigo, L, Chavez, M, Trujillo, R, Legros, V, Brochet, B, Huet, O, Geslain, M, van der Jagt, M, van Steenkiste, J, Ahmed, H, Coombs, A, Welbourne, J, Pineda, A, Castillo, V, Azab, M, Azzam, A, van Meenen, D, Gasca, G, Arellano, A, Galicia-Espinosa, F, García-Ramos, J, Yadav, G, Jha, A, Robert-Edan, V, Rodie-Talbere, P, Jain, G, Panda, S, Agarwal, S, Deewan, Y, Reza, S, Hossain, M, Papadas, C, Chantziara, V, Sklavou, C, Hourmant, Y, Grillot, N, Pirracchio, R, Akkari, A, Abdelaty, M, Hashim, A, Launey, Y, Masseret, E, Lasocki, S, Gergaud, S, Mouclier, N, Saxena, S, Agrawal, A, Mishra, S, Samal, S, Mijangos, J, Haënggi, M, Gurjar, M, Kaye, C, Godoy, D, Alvarez, P, Ioakeimidou, A, Ueno, Y, Elbuzidi, A, Piagnerelli, M, Elhadi, M, Digitale, J, Fong, N, Cerda, R, de la Torre Peredo, N, Mccredie, V, Suei, E, Haenggi, M, Samir, J, Robba, Chiara, Battaglini, Denise, Abbas, Abbas, Sarrió, Ezequiel, Cinotti, Raphael, Asehnoune, Karim, Taccone, Fabio S., Rocco, Patricia R., Schultz, Marcus J., Citerio, Giuseppe, Stevens, Robert David, Badenes, Rafael, Abback, Paër-Sélim, Codorniu, Anaïs, Sala, Vittoria Ludovica, Astuto, Marinella, Tringali, Eleonora, Alampi, Daniela, Rocco, Monica, Maugeri, Jessica Giuseppina, Bellissima, Agrippino, Filippini, Matteo, Lazzeri, Nicoletta, Cortegiani, Andrea, Ippolito, Mariachiara, Biston, Patrick, Al-Gharyani, Mohamed Fathi, Chabanne, Russell, Astier, Léo, Soyer, Benjamin, Gaugain, Samuel, Zimmerli, Alice, Pietsch, Urs, Filipovic, Miodrag, Brandi, Giovanna, Bicciato, Giulio, Serrano, Ainhoa, Monleon, Berta, van Vliet, Peter, Gerretsen, Benjamin Marcel, Ortiz-Macias, Iris Xochitl, Oto, Jun, Enomoto, Noriya, Matsuda, Tomomichi, Masui, Nobutaka, Garçon, Pierre, Zarka, Jonathan, Vermeijden, Wytze J., Cornet, Alexander Daniel, Gard, Sergio Reyes Infra, Domínguez, Rafael Cirino Lara, Bellini, Maria Mercedes, Haedo, Maria Milagros Gomez, Lamot, Laura, Orquera, Jose, Biais, Matthieu, Georges, Delphine, Baronial, Arvind, Miranda-Ackerman, Roberto Carlos, Barbosa-Camacho, Francisco José, Porter, John, Lopez-Morales, Miguel, Geeraerts, Thomas, Companion, Baptiste, Pérez-Torres, David, Prol-Silva, Estefanía, Yahya, Hana Basheer, Khaled, Ala, Ghulam, Mohamed, Andrea, Cracchiolo Neville, Daniela, Palma Maria, Deana, Cristian, Vertigo, Luigi, Chavez, Manuel J. Rivera, Trujillo, Rocio Mendoza, Legros, Vincent, Brochet, Benjamin, Huet, Olivier, Geslain, Marie, van der Jagt, Mathieu, van Steenkiste, Job, Ahmed, Hazem, Coombs, Alexander Edward, Welbourne, Jessie, Pineda, Ana Alicia Velarde, Castillo, Víctor Hugo Nubert, Azab, Mohammed A., Azzam, Ahmed Y., van Meenen, David Michael Paul, Gasca, Gilberto Adrian, Arellano, Alfredo, Galicia-Espinosa, Forttino, García-Ramos, José Carlos, Yadav, Ghanshyam, Jha, Amarendra Kumar, Robert-Edan, Vincent, Rodie-Talbere, Pierre-Andre, Jain, Gaurav, Panda, Sagarika, Agarwal, Sonika, Deewan, Yashbir, Reza, Syed Tariq, Hossain, Md. Mozaffer, Papadas, Christos, Chantziara, Vasiliki, Sklavou, Chrysanthi, Hourmant, Yannick, Grillot, Nicolas, Pirracchio, Romain, Akkari, Abdelraouf, Abdelaty, Mohamed, Hashim, Ahmed, Launey, Yoann, Masseret, Elodie, Lasocki, Sigismond, Gergaud, Soizic, Mouclier, Nicolas, Saxena, Sulekha, Agrawal, Avinash, Mishra, Shakti Bedanta, Samal, Samir, Mijangos, Julio Cesar, Haënggi, Mattias, Gurjar, Mohan, Kaye, Callum, Godoy, Daniela Agustin, Alvarez, Pablo, Ioakeimidou, Aikaterini, Ueno, Yoshitoyo, Elbuzidi, Abdurrahmaan Ali Suei, Piagnerelli, Michaël, Elhadi, Muhammed, Azab, Mohammed Atef, Digitale, Jean Catherine, Fong, Nicholas, Cerda, Ricardo Campos, de la Torre Peredo, Norma, McCredie, Victoria, Suei, Elbuzidi Abdurrahmaan Ali, Haenggi, Matthias, Samir, Jaber, Robba, C, Battaglini, D, Abbas, A, Sarrió, E, Cinotti, R, Asehnoune, K, Taccone, F, Rocco, P, Schultz, M, Citerio, G, Stevens, R, Badenes, R, Abback, P, Codorniu, A, Sala, V, Astuto, M, Tringali, E, Alampi, D, Rocco, M, Maugeri, J, Bellissima, A, Filippini, M, Lazzeri, N, Cortegiani, A, Ippolito, M, Biston, P, Al-Gharyani, M, Chabanne, R, Astier, L, Soyer, B, Gaugain, S, Zimmerli, A, Pietsch, U, Filipovic, M, Brandi, G, Bicciato, G, Serrano, A, Monleon, B, van Vliet, P, Gerretsen, B, Ortiz-Macias, I, Oto, J, Enomoto, N, Matsuda, T, Masui, N, Garçon, P, Zarka, J, Vermeijden, W, Cornet, A, Gard, S, Domínguez, R, Bellini, M, Haedo, M, Lamot, L, Orquera, J, Biais, M, Georges, D, Baronial, A, Miranda-Ackerman, R, Barbosa-Camacho, F, Porter, J, Lopez-Morales, M, Geeraerts, T, Companion, B, Pérez-Torres, D, Prol-Silva, E, Yahya, H, Khaled, A, Ghulam, M, Andrea, C, Daniela, P, Deana, C, Vertigo, L, Chavez, M, Trujillo, R, Legros, V, Brochet, B, Huet, O, Geslain, M, van der Jagt, M, van Steenkiste, J, Ahmed, H, Coombs, A, Welbourne, J, Pineda, A, Castillo, V, Azab, M, Azzam, A, van Meenen, D, Gasca, G, Arellano, A, Galicia-Espinosa, F, García-Ramos, J, Yadav, G, Jha, A, Robert-Edan, V, Rodie-Talbere, P, Jain, G, Panda, S, Agarwal, S, Deewan, Y, Reza, S, Hossain, M, Papadas, C, Chantziara, V, Sklavou, C, Hourmant, Y, Grillot, N, Pirracchio, R, Akkari, A, Abdelaty, M, Hashim, A, Launey, Y, Masseret, E, Lasocki, S, Gergaud, S, Mouclier, N, Saxena, S, Agrawal, A, Mishra, S, Samal, S, Mijangos, J, Haënggi, M, Gurjar, M, Kaye, C, Godoy, D, Alvarez, P, Ioakeimidou, A, Ueno, Y, Elbuzidi, A, Piagnerelli, M, Elhadi, M, Digitale, J, Fong, N, Cerda, R, de la Torre Peredo, N, Mccredie, V, Suei, E, Haenggi, M, Samir, J, Robba, Chiara, Battaglini, Denise, Abbas, Abbas, Sarrió, Ezequiel, Cinotti, Raphael, Asehnoune, Karim, Taccone, Fabio S., Rocco, Patricia R., Schultz, Marcus J., Citerio, Giuseppe, Stevens, Robert David, Badenes, Rafael, Abback, Paër-Sélim, Codorniu, Anaïs, Sala, Vittoria Ludovica, Astuto, Marinella, Tringali, Eleonora, Alampi, Daniela, Rocco, Monica, Maugeri, Jessica Giuseppina, Bellissima, Agrippino, Filippini, Matteo, Lazzeri, Nicoletta, Cortegiani, Andrea, Ippolito, Mariachiara, Biston, Patrick, Al-Gharyani, Mohamed Fathi, Chabanne, Russell, Astier, Léo, Soyer, Benjamin, Gaugain, Samuel, Zimmerli, Alice, Pietsch, Urs, Filipovic, Miodrag, Brandi, Giovanna, Bicciato, Giulio, Serrano, Ainhoa, Monleon, Berta, van Vliet, Peter, Gerretsen, Benjamin Marcel, Ortiz-Macias, Iris Xochitl, Oto, Jun, Enomoto, Noriya, Matsuda, Tomomichi, Masui, Nobutaka, Garçon, Pierre, Zarka, Jonathan, Vermeijden, Wytze J., Cornet, Alexander Daniel, Gard, Sergio Reyes Infra, Domínguez, Rafael Cirino Lara, Bellini, Maria Mercedes, Haedo, Maria Milagros Gomez, Lamot, Laura, Orquera, Jose, Biais, Matthieu, Georges, Delphine, Baronial, Arvind, Miranda-Ackerman, Roberto Carlos, Barbosa-Camacho, Francisco José, Porter, John, Lopez-Morales, Miguel, Geeraerts, Thomas, Companion, Baptiste, Pérez-Torres, David, Prol-Silva, Estefanía, Yahya, Hana Basheer, Khaled, Ala, Ghulam, Mohamed, Andrea, Cracchiolo Neville, Daniela, Palma Maria, Deana, Cristian, Vertigo, Luigi, Chavez, Manuel J. Rivera, Trujillo, Rocio Mendoza, Legros, Vincent, Brochet, Benjamin, Huet, Olivier, Geslain, Marie, van der Jagt, Mathieu, van Steenkiste, Job, Ahmed, Hazem, Coombs, Alexander Edward, Welbourne, Jessie, Pineda, Ana Alicia Velarde, Castillo, Víctor Hugo Nubert, Azab, Mohammed A., Azzam, Ahmed Y., van Meenen, David Michael Paul, Gasca, Gilberto Adrian, Arellano, Alfredo, Galicia-Espinosa, Forttino, García-Ramos, José Carlos, Yadav, Ghanshyam, Jha, Amarendra Kumar, Robert-Edan, Vincent, Rodie-Talbere, Pierre-Andre, Jain, Gaurav, Panda, Sagarika, Agarwal, Sonika, Deewan, Yashbir, Reza, Syed Tariq, Hossain, Md. Mozaffer, Papadas, Christos, Chantziara, Vasiliki, Sklavou, Chrysanthi, Hourmant, Yannick, Grillot, Nicolas, Pirracchio, Romain, Akkari, Abdelraouf, Abdelaty, Mohamed, Hashim, Ahmed, Launey, Yoann, Masseret, Elodie, Lasocki, Sigismond, Gergaud, Soizic, Mouclier, Nicolas, Saxena, Sulekha, Agrawal, Avinash, Mishra, Shakti Bedanta, Samal, Samir, Mijangos, Julio Cesar, Haënggi, Mattias, Gurjar, Mohan, Kaye, Callum, Godoy, Daniela Agustin, Alvarez, Pablo, Ioakeimidou, Aikaterini, Ueno, Yoshitoyo, Elbuzidi, Abdurrahmaan Ali Suei, Piagnerelli, Michaël, Elhadi, Muhammed, Azab, Mohammed Atef, Digitale, Jean Catherine, Fong, Nicholas, Cerda, Ricardo Campos, de la Torre Peredo, Norma, McCredie, Victoria, Suei, Elbuzidi Abdurrahmaan Ali, Haenggi, Matthias, and Samir, Jaber

Abstract

Purpose: The use of arterial partial pressure of carbon dioxide (PaCO2) as a target intervention to manage elevated intracranial pressure (ICP) and its effect on clinical outcomes remain unclear. We aimed to describe targets for PaCO2 in acute brain injured (ABI) patients and assess the occurrence of abnormal PaCO2 values during the first week in the intensive care unit (ICU). The secondary aim was to assess the association of PaCO2 with in-hospital mortality. Methods: We carried out a secondary analysis of a multicenter prospective observational study involving adult invasively ventilated patients with traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), intracranial hemorrhage (ICH), or ischemic stroke (IS). PaCO2 was collected on day 1, 3, and 7 from ICU admission. Normocapnia was defined as PaCO2 > 35 and to 45 mmHg; mild hypocapnia as 32–35 mmHg; severe hypocapnia as 26–31 mmHg, forced hypocapnia as < 26 mmHg, and hypercapnia as > 45 mmHg. Results: 1476 patients (65.9% male, mean age 52 ± 18 years) were included. On ICU admission, 804 (54.5%) patients were normocapnic (incidence 1.37 episodes per person/day during ICU stay), and 125 (8.5%) and 334 (22.6%) were mild or severe hypocapnic (0.52 and 0.25 episodes/day). Forced hypocapnia and hypercapnia were used in 40 (2.7%) and 173 (11.7%) patients. PaCO2 had a U-shape relationship with in-hospital mortality with only severe hypocapnia and hypercapnia being associated with increased probability of in-hospital mortality (omnibus p value = 0.0009). Important differences were observed across different subgroups of ABI patients. Conclusions: Normocapnia and mild hypocapnia are common in ABI patients and do not affect patients' outcome. Extreme derangements of PaCO2 values were significantly associated with increased in-hospital mortality.

Published
2024

27. The use of tier three therapies in acute brain injured patients

Author

Iaquaniello, C, Gallo, F, Cinotti, R, Citerio, G, Taccone, F, Pelosi, P, Badenes, R, Robba, C, Iaquaniello, Carolina, Gallo, Fabio, Cinotti, Raphael, Citerio, Giuseppe, Taccone, Fabio S., Pelosi, Paolo, Badenes, Rafael, Robba, Chiara, Iaquaniello, C, Gallo, F, Cinotti, R, Citerio, G, Taccone, F, Pelosi, P, Badenes, R, Robba, C, Iaquaniello, Carolina, Gallo, Fabio, Cinotti, Raphael, Citerio, Giuseppe, Taccone, Fabio S., Pelosi, Paolo, Badenes, Rafael, and Robba, Chiara

Abstract

BACKGROUND In patients with acute brain injury (ABI) and refractory intracranial hypertension, the so-called ‘tier three therapies’ (TTT) (hypothermia, metabolic suppression with barbiturates, and decompressive craniectomy) may be used. OBJECTIVE We aimed to describe the incidence of use of TTT, and to assess their effect on outcome. DESIGN A secondary analysis of the ENIO observational study. SETTING Seventy-three intensive care units (ICUs) in 18 countries worldwide between June 2018 and November 2020. PATIENTS One thousand five hundred and twelve adult patients admitted to an intensive care unit (ICU) with ABI were included and categorised according to use or not of one or more TTT. RESULTS Three hundred and ninety-six patients (26.2%) received at least one TTT during the ICU stay. Five patients (0.3%) received all three TTT. TTT patients were younger (P < 0.0001), less likely to have a preinjury history of hypertension (P = 0.0008), and less frequently anisocoric within 24 h from ICU admission (P < 0.0001) than those with no tier three therapy. TTT were used less frequently in high-income countries than in upper income and lower middle-income countries (no TTT in 78% of patients in high-income countries, in 60.6% of patients in upper middle-income countries, and in 56.6% of patients in lower middle-income countries; P < 0.0001). TTT were more frequent in patients with traumatic brain injury (TBI) compared with other types of ABI and in patients with invasive intracranial pressure (ICP) monitoring (P < 0.0001). TTT use was associated with a higher incidence of ventilator-associated pneumonia (P < 0.0001), need for tracheostomy (P = 0.0194), and prolonged ICU length of stay (LOS; P < 0.0001) but not with increased ICU or hospital mortality (P = 0.999). CONCLUSION Patients with ABI are frequently managed using at least one TTT. Their use varies according to a country's economic resources, the type of ABI, and ICP monitoring and is associated with

Published
2024

28. Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus

Author

Robba, Chiara, Poole, Daniele, McNett, Molly, Asehnoune, Karim, Bösel, Julian, Bruder, Nicolas, Chieregato, Arturo, Cinotti, Raphael, Duranteau, Jacques, Einav, Sharon, Ercole, Ari, Ferguson, Niall, Guerin, Claude, Siempos, Ilias I., Kurtz, Pedro, Juffermans, Nicole P., Mancebo, Jordi, Mascia, Luciana, McCredie, Victoria, Nin, Nicolas, Oddo, Mauro, Pelosi, Paolo, Rabinstein, Alejandro A., Neto, Ary Serpa, Seder, David B., Skrifvars, Markus B., Suarez, Jose I., Taccone, Fabio Silvio, van der Jagt, Mathieu, Citerio, Giuseppe, and Stevens, Robert D.

Published
2020
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29. Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis

Author

Roquilly, Antoine, Jacqueline, Cedric, Davieau, Marion, Mollé, Alice, Sadek, Abderrahmane, Fourgeux, Cynthia, Rooze, Paul, Broquet, Alexis, Misme-Aucouturier, Barbara, Chaumette, Tanguy, Vourc’h, Mickael, Cinotti, Raphael, Marec, Nadege, Gauttier, Vanessa, McWilliam, Hamish E. G., Altare, Frederic, Poschmann, Jeremie, Villadangos, Jose A., and Asehnoune, Karim

Published
2020
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30. Assessment of remifentanil for rapid sequence induction and intubation in patients at risk of pulmonary aspiration of gastric contents compared to rapid-onset paralytic agents: study protocol for a non-inferiority simple blind randomized controlled trial (the REMICRUSH study)

Author

Grillot, Nicolas, Garot, Matthias, Lasocki, Sigismond, Huet, Olivier, Bouzat, Pierre, Le Moal, Charlène, Oudot, Mathieu, Chatel-Josse, Nolwenn, El Amine, Younes, Danguy des Déserts, Marc, Bruneau, Nathalie, Cinotti, Raphael, David, Jean-Stéphane, Langeron, Olivier, Minville, Vincent, Tching-Sin, Martine, Faurel-Paul, Elodie, Lerebourg, Céline, Flattres-Duchaussoy, Delphine, Jobert, Alexandra, Asehnoune, Karim, Feuillet, Fanny, and Roquilly, Antoine

Published
2021
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34. Should We Reconsider Pneumocystis Pneumonia Presentation and Treatment According to Its Underlying Disease?: An Unsupervised Cluster Analysis of a Retrospective Multicenter Study

Author

Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Lécuyer, Romain, Asquier-Khati, Antoine, Pineau, Valentin, Prime, Marie, Delaunay, Clarisse, Essid, Hakim, Le Pape, Patrice, Morio, Florent, Lavergne, Rose-Anne, Jeddi, Fakhri, Corvec, Stéphane, Bemer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Leroy, Anne-Gaëlle, Lakhal, Karim, Cinotti, Raphaël, Roquilly, Antoine, Jean Reignier, Mickael Vourc’h, Canet, Emmanuel, Blanc, François Xavier, Bretonniere, Cédric, Morin, Jean, Le Blanc, Camille, Alami, Hakim, Camou, Fabrice, Issa, Nahéma, Guisset, Olivier, Mourissoux, Gaelle, Accoceberry, Isabelle, Gabriel, Frederic, Coron, Noémie, Delhaes, Laurence, Imbert, Sébastien, Lefranc, Maxime, Lussac-Sorton, Florian, Rougeron, Amandine, Gousseff, Marie, Crabol, Yoann, Corvaisier, Grégory, Lautredoux, Florent, Anne Cady, Romain Lécuyerand, Auger, Myriam, Pouedras, Pascal, Gaborit, Benjamin, Lavergne, Rose-anne, Raffi, François, Cady, Anne, Néel, Antoine, and Tessoulin, Benoît

Published
2024
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36. Individualized Thresholds of Hypoxemia and Hyperoxemia and their Effect on Outcome in Acute Brain Injured Patients: A Secondary Analysis of the ENIO Study

Author

Robba, Chiara, Battaglini, Denise, Cinotti, Raphael, Asehnoune, Karim, Stevens, Robert, Taccone, Fabio Silvio, Badenes, Rafael, Pelosi, Paolo, ENIO collaborators including, Cortegiani, Andrea, Ippolito, Mariachiara, Robba, Chiara, Battaglini, Denise, Cinotti, Raphael, Asehnoune, Karim, Stevens, Robert, Taccone, Fabio Silvio, Badenes, Rafael, Pelosi, Paolo, ENIO collaborators including, Cortegiani, Andrea, and Ippolito, Mariachiara

Subjects
Oxygen, Brain injury, Hyperoxia, Critically ill, Hyperoxemia, Outcome
Abstract

Background: In acute brain injury (ABI), the effects of hypoxemia as a potential cause of secondary brain damage and poor outcome are well documented, whereas the impact of hyperoxemia is unclear. The primary aim of this study was to assess the episodes of hypoxemia and hyperoxemia in patients with ABI during the intensive care unit (ICU) stay and to determine their association with in-hospital mortality. The secondary aim was to identify the optimal thresholds of arterial partial pressure of oxygen (PaO2) predicting in-hospital mortality. Methods: We conducted a secondary analysis of a prospective multicenter observational cohort study. Adult patients with ABI (traumatic brain injury, subarachnoid aneurysmal hemorrhage, intracranial hemorrhage, ischemic stroke) with available data on PaO2 during the ICU stay were included. Hypoxemia was defined as PaO2

Published
2023

37. Ferric derisomaltose and tranexamic acid, combined or alone, for reducing blood transfusion in patients with hip fracture (the HiFIT trial): a multicentre, 2 × 2 factorial, randomised, double-blind, controlled trial

Author

Lasocki, Sigismond, primary, Capdevila, Xavier, additional, Vielle, Bruno, additional, Bijok, Benjamin, additional, Lahlou-Casulli, Maria, additional, Collange, Vincent, additional, Grillot, Nicolas, additional, Danguy des Deserts, Marc, additional, Duchalais, Alexis, additional, Delannoy, Bertrand, additional, Drugeon, Bertrand, additional, Bouzat, Pierre, additional, David, Jean-Stéphane, additional, Rony, Louis, additional, Loupec, Thibault, additional, Léger, Maxime, additional, Rineau, Emmanuel, additional, Bouhours, Guillaume, additional, Lasocki, Sigismond, additional, Lebail, Adeline, additional, Parot-Schinkel, Elsa, additional, Capdevilla, Xavier, additional, Mounet, Benjamin, additional, Swisser, Fabien, additional, Cinotti, Raphael, additional, Asehnoune, Karim, additional, Roquilly, Antoine, additional, Beloeil, Hélène, additional, Parent, Sébastien, additional, Desebbe, Olivier, additional, Guenezan, Jeremy, additional, Drevet, Sabine, additional, Gavazzi, Gaetan, additional, Greze, Jules, additional, and Garrigue, Delphine, additional

Published
2023
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41. Incidence and Outcomes of Acute Respiratory Distress Syndrome in Brain-Injured Patients Receiving Invasive Ventilation: A Secondary Analysis of the ENIO Study.

Author

Taran, Shaurya, Stevens, Robert D., Perrot, Bastien, McCredie, Victoria A., Cinotti, Raphael, Asehnoune, Karim, Pelosi, Paolo, and Robba, Chiara

Subjects
ADULT respiratory distress syndrome, BRAIN injuries, SUBARACHNOID hemorrhage, INTRACRANIAL hemorrhage, CONFIDENCE intervals
Abstract

Background: Acute respiratory distress syndrome (ARDS) is an important pulmonary complication in brain-injured patients receiving invasive mechanical ventilation (IMV). We aimed to evaluate the incidence and association between ARDS and clinical outcomes in patients with different forms of acute brain injury requiring IMV in the intensive care unit (ICU). Methods: This was a preplanned secondary analysis of a prospective, multicenter, international cohort study (NCT 03400904). We included brain-injured patients receiving IMV for ≥ 24 h. ARDS was the main exposure of interest and was identified during index ICU admission using the Berlin definition. We examined the incidence and adjusted association of ARDS with ICU mortality, ICU length of stay, duration of IMV, and extubation failure. Outcomes were evaluated using mixed-effect logistic regression and cause-specific Cox proportional hazards models. Results: 1492 patients from 67 hospitals and 16 countries were included in the analysis, of whom 137 individuals developed ARDS (9.2% of overall cohort). Across countries, the median ARDS incidence was 5.1% (interquartile range [IQR] 0-10; range 0-27.3). ARDS was associated with increased ICU mortality (adjusted odds ratio (OR) 2.66; 95% confidence interval [CI], 1.29-5.48), longer ICU length of stay (adjusted hazard ratio [HR] 0.59; 95% CI, 0.48-0.73), and longer duration of IMV (adjusted HR 0.54; 95% CI, 0.44-0.67). The association between ARDS and extubation failure approached statistical significance (adjusted HR 1.48; 95% CI 0.99-2.21). Higher ARDS severity was associated with incrementally longer ICU length of stay and longer cumulative duration of IMV. Findings remained robust in a sensitivity analysis evaluating the magnitude of unmeasured confounding. Conclusions: In this cohort of acutely brain-injured patients, the incidence of ARDS was similar to that reported in other mixed cohorts of critically ill patients. Development of ARDS was associated with worse outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Association of Non-Invasive Respiratory Support with Extubation Outcomes in Brain-Injured Patients Receiving Mechanical Ventilation: A Secondary Analysis of ENIO

Author

Taran, Shaurya, primary, Diaz-Cruz, Camilo, additional, Perrot, Bastien, additional, Alvarez, Pablo, additional, Godoy, Daniel Agustin, additional, Gurjar, Mohan, additional, Haenggi, Matthias, additional, Mijangos, Julio Cesar, additional, Pelosi, Paolo, additional, Robba, Chiara, additional, Schultz, Marcus J., additional, Ueno, Yoshitoyo, additional, Asehnoune, Karim, additional, Cho, Sung Min, additional, Yarnell, Christopher J, additional, Cinotti, Raphael, additional, and Stevens, Robert D, additional

Published
2023
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44. A multifaceted strategy to optimize pharmacokinetics of antimicrobial therapy in patients with hospital-acquired infections—a monocentre quality improvement project

Author

Lagarde, Cecile, primary, Bouras, Marwan, additional, Le Floch, Ronan, additional, Hourmant, Yannick, additional, Grillot, Nicolas, additional, Bourdiol, Alexandre, additional, Mahe, Pierre Joachim, additional, Demeure Dit Latte, Dominique, additional, Gregoire, Matthieu, additional, Dailly, Eric, additional, Bellouard, Ronan, additional, Asehnoune, Karim, additional, Cinotti, Raphael, additional, and Roquilly, Antoine, additional

Published
2023
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47. Relationship between health-related quality-of-life and functional outcome 6 months after moderate to severe TBI.

Author

Cinotti, Raphaël, Roquilly, Antoine, Chopin, Alice, Martin, Florian Pierre, Morato, Yoanna, Lerebourg, Céline, Moyer, Jean Denis, Huet, Olivier, Lasocki, Sigismond, Cohen, Benjamin, Dahyot-Fizelier, Claire, Chalard, Kevin, Seguin, Philippe, Chenet, Amandine, Perrouin-Verbe, Brigitte, Sinha, Debajyoti, Asehnoune, Karim, Feuillet, Fanny, and Sébille, Véronique

Published
2023
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48. Effect of Remifentanil vs Neuromuscular Blockers During Rapid Sequence Intubation on Successful Intubation Without Major Complications Among Patients at Risk of Aspiration: A Randomized Clinical Trial

Author

Grillot, Nicolas, Lebuffe, Gilles, Huet, Olivier, Lasocki, Sigismond, Pichon, Xavier, Oudot, Mathieu, Bruneau, Nathalie, David, Jean-Stéphane, Bouzat, Pierre, Jobert, Alexandra, Tching-Sin, Martine, Feuillet, Fanny, Cinotti, Raphael, Asehnoune, Karim, and Roquilly, Antoine

Subjects
Adult, Male, Remifentanil, Intubation, Intratracheal, Humans, Hypnotics and Sedatives, Female, General Medicine, Middle Aged, Rapid Sequence Induction and Intubation, Neuromuscular Blocking Agents, Original Investigation
Abstract

ImportanceIt is uncertain whether a rapid-onset opioid is noninferior to a rapid-onset neuromuscular blocker during rapid sequence intubation when used in conjunction with a hypnotic agent.ObjectiveTo determine whether remifentanil is noninferior to rapid-onset neuromuscular blockers for rapid sequence intubation.Design, Setting, and ParticipantsMulticenter, randomized, open-label, noninferiority trial among 1150 adults at risk of aspiration (fasting for InterventionsPatients were randomized to receive neuromuscular blockers (1 mg/kg of succinylcholine or rocuronium; n = 575) or remifentanil (3 to 4 μg/kg; n = 575) immediately after injection of a hypnotic.Main Outcomes and MeasuresThe primary outcome was assessed in all randomized patients (as-randomized population) and in all eligible patients who received assigned treatment (per-protocol population). The primary outcome was successful tracheal intubation on the first attempt without major complications, defined as lung aspiration of digestive content, oxygen desaturation, major hemodynamic instability, sustained arrhythmia, cardiac arrest, and severe anaphylactic reaction. The prespecified noninferiority margin was 7.0%.ResultsAmong 1150 randomized patients (mean age, 50.7 [SD, 17.4] years; 573 [50%] women), 1130 (98.3%) completed the trial. In the as-randomized population, tracheal intubation on the first attempt without major complications occurred in 374 of 575 patients (66.1%) in the remifentanil group and 408 of 575 (71.6%) in the neuromuscular blocker group (between-group difference adjusted for randomization strata and center, –6.1%; 95% CI, –11.6% to –0.5%; P = .37 for noninferiority), demonstrating inferiority. In the per-protocol population, 374 of 565 patients (66.2%) in the remifentanil group and 403 of 565 (71.3%) in the neuromuscular blocker group had successful intubation without major complications (adjusted difference, –5.7%; 2-sided 95% CI, –11.3% to –0.1%; P = .32 for noninferiority). An adverse event of hemodynamic instability was recorded in 19 of 575 patients (3.3%) with remifentanil and 3 of 575 (0.5%) with neuromuscular blockers (adjusted difference, 2.8%; 95% CI, 1.2%-4.4%).Conclusions and RelevanceAmong adults at risk of aspiration during rapid sequence intubation in the operating room, remifentanil, compared with neuromuscular blockers, did not meet the criterion for noninferiority with regard to successful intubation on first attempt without major complications. Although remifentanil was statistically inferior to neuromuscular blockers, the wide confidence interval around the effect estimate remains compatible with noninferiority and limits conclusions about the clinical relevance of the difference.Trial RegistrationClinicalTrials.gov Identifier: NCT03960801

Published
2023

49. Author Correction: Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis

Author

Roquilly, Antoine, Jacqueline, Cedric, Davieau, Marion, Mollé, Alice, Sadek, Abderrahmane, Fourgeux, Cynthia, Rooze, Paul, Broquet, Alexis, Misme-Aucouturier, Barbara, Chaumette, Tanguy, Vourc’h, Mickael, Cinotti, Raphael, Marec, Nadege, Gauttier, Vanessa, McWilliam, Hamish E. G., Altare, Frederic, Poschmann, Jeremie, Villadangos, Jose A., and Asehnoune, Karim

Published
2020
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