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1,006 results on '"Cinti, Saverio"'

2. Tessuto adiposo epicardico: dagli aspetti biomolecolari alla pratica clinica

Author

Malavazos, Alexis Elias, Dubini, Carola, Meregalli, Chiara, Boniardi, Federico, Secchi, Francesco, Piepoli, Massimo, Salvetti, Guido, Menicanti, Lorenzo, Chessa, Massimo, Spagnolo, Pietro, Scravaglieri, Valentina, Trevisan, Manuel Bruno, Fierabracci, Paola, Dozio, Elena, Buscemi, Paolo, Castelvecchio, Serenella, Ruocco, Chiara, Randazzo, Cristiana, Morricone, Lelio, Santini, Ferruccio, Cinti, Saverio, Buscemi, Silvio, Guazzi, Marco, Romanelli, Massimiliano Marco Corsi, Carruba, Michele Olivo, and Nisoli, Enzo

Published
2024
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3. Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood

Author

Lin, Lin, Jung, Kwang-Mook, Lee, Hye-Lim, Le, Johnny, Colleluori, Georgia, Wood, Courtney, Palese, Francesca, Squire, Erica, Ramirez, Jade, Su, Shiqi, Torrens, Alexa, Fotio, Yannick, Tang, Lingyi, Yu, Clinton, Yang, Qin, Huang, Lan, DiPatrizio, Nicholas, Jang, Cholsoon, Cinti, Saverio, and Piomelli, Daniele

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Pediatric, Drug Abuse (NIDA only), Substance Misuse, Obesity, Nutrition, Cannabinoid Research, 2.1 Biological and endogenous factors, Metabolic and endocrine, Mice, Male, Animals, Dronabinol, Adiposity, Energy Intake, Homeostasis, 2-arachidonoylglycerol, adipocyte, anandamide, cannabis, endocannabinoids, Biochemistry and Cell Biology, Medical Biochemistry and Metabolomics, Endocrinology & Metabolism, Biochemistry and cell biology, Medical biochemistry and metabolomics
Abstract

One of cannabis' most iconic effects is the stimulation of hedonic high-calorie eating-the "munchies"-yet habitual cannabis users are, on average, leaner than non-users. We asked whether this phenotype might result from lasting changes in energy balance established during adolescence, when use of the drug often begins. We found that daily low-dose administration of cannabis' intoxicating constituent, Δ9-tetrahydrocannabinol (THC), to adolescent male mice causes an adult metabolic phenotype characterized by reduced fat mass, increased lean mass and utilization of fat as fuel, partial resistance to diet-induced obesity and dyslipidemia, enhanced thermogenesis, and impaired cold- and β-adrenergic receptor-stimulated lipolysis. Further analyses revealed that this phenotype is associated with molecular anomalies in the adipose organ, including ectopic overexpression of muscle-associated proteins and heightened anabolic processing. Thus, adolescent exposure to THC may promote an enduring "pseudo-lean" state that superficially resembles healthy leanness but might in fact be rooted in adipose organ dysfunction.

Published
2023

5. In humans increase in intrapancreatic adipose tissue predicts beta-cell dedifferentiation score before diabetes onset: A pilot study

Author

Cinti, Francesca, Mezza, Teresa, Severi, Ilenia, Moffa, Simona, Giuseppe, Gianfranco Di, Capece, Umberto, Ciccarelli, Gea, Soldovieri, Laura, Brunetti, Michela, Morciano, Cassandra, Gugliandolo, Shawn, Senzacqua, Martina, Avolio, Adriana, Quero, Giuseppe, Tondolo, Vincenzo, Nista, Enrico Celestino, Moroni, Rossana, Cinti, Saverio, Alfieri, Sergio, Gasbarrini, Antonio, Pontecorvi, Alfredo, and Giaccari, Andrea

Published
2025
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7. Recruitment and remodeling of peridroplet mitochondria in human adipose tissue

Author

Acín-Perez, Rebeca, Petcherski, Anton, Veliova, Michaela, Benador, Ilan Y, Assali, Essam A, Colleluori, Georgia, Cinti, Saverio, Brownstein, Alexandra J, Baghdasarian, Siyouneh, Livhits, Masha J, Yeh, Michael W, Krishnan, Karthickeyan Chella, Vergnes, Laurent, Winn, Nathan C, Padilla, Jaume, Liesa, Marc, Sacks, Harold S, and Shirihai, Orian S

Subjects
Biochemistry and Cell Biology, Biological Sciences, Nutrition, Metabolic and endocrine, Adipocytes, Brown, Adipose Tissue, Brown, Adipose Tissue, White, Animals, Energy Metabolism, Humans, Mice, Mitochondria, Thermogenesis, Adipose tissue, Pheochromocytoma, Peridroplet mitochondria, Bioenergetics, Endocrinology, Medical Biochemistry and Metabolomics, Pharmacology and Pharmaceutical Sciences, Biochemistry and cell biology, Medicinal and biomolecular chemistry
Abstract

Beige adipocyte mitochondria contribute to thermogenesis by uncoupling and by ATP-consuming futile cycles. Since uncoupling may inhibit ATP synthesis, it is expected that expenditure through ATP synthesis is segregated to a disparate population of mitochondria. Recent studies in mouse brown adipocytes identified peridroplet mitochondria (PDM) as having greater ATP synthesis and pyruvate oxidation capacities, while cytoplasmic mitochondria have increased fatty acid oxidation and uncoupling capacities. However, the occurrence of PDM in humans and the processes that result in their expansion have not been elucidated. Here, we describe a novel high-throughput assay to quantify PDM that is successfully applied to white adipose tissue from mice and humans. Using this approach, we found that PDM content varies between white and brown fat in both species. We used adipose tissue from pheochromocytoma (Pheo) patients as a model of white adipose tissue browning, which is characterized by an increase in the capacity for energy expenditure. In contrast with control subjects, PDM content was robustly increased in the periadrenal fat of Pheo patients. Remarkably, bioenergetic changes associated with browning were primarily localized to PDM compared to cytoplasmic mitochondria (CM). PDM isolated from periadrenal fat of Pheo patients had increased ATP-linked respiration, Complex IV content and activity, and maximal respiratory capacity. We found similar changes in a mouse model of re-browning where PDM content in whitened brown adipose tissue was increased upon re-browning induced by decreased housing temperature. Taken together, this study demonstrates the existence of PDM as a separate functional entity in humans and that browning in both mice and humans is associated with a robust expansion of peri-droplet mitochondria characterized by increased ATP synthesis linked respiration.

Published
2021

9. From Obesity to Diabetes: The Role of the Adipose Organ

Author

Colleluori, Georgia, Perugini, Jessica, Giordano, Antonio, Cinti, Saverio, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Kuner, Rohini, Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Eckel, Juergen, editor, and Clément, Karine, editor

Published
2022
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13. Uterine leiomyoma as useful model to unveil morphometric and macromolecular collagen state and impairment in fibrotic diseases: An ex-vivo human study

Author

Belloni, Alessia, Furlani, Michele, Greco, Stefania, Notarstefano, Valentina, Pro, Chiara, Randazzo, Basilio, Pellegrino, Pamela, Zannotti, Alessandro, Carpini, Giovanni Delli, Ciavattini, Andrea, Di Lillo, Francesca, Giorgini, Elisabetta, Giuliani, Alessandra, Cinti, Saverio, and Ciarmela, Pasquapina

Published
2022
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15. Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion

Author

Benador, Ilan Y, Veliova, Michaela, Mahdaviani, Kiana, Petcherski, Anton, Wikstrom, Jakob D, Assali, Essam A, Acín-Pérez, Rebeca, Shum, Michaël, Oliveira, Marcus F, Cinti, Saverio, Sztalryd, Carole, Barshop, William D, Wohlschlegel, James A, Corkey, Barbara E, Liesa, Marc, and Shirihai, Orian S

Subjects
Biochemistry and Cell Biology, Biological Sciences, 2.1 Biological and endogenous factors, Adenosine Triphosphate, Adipocytes, Adipose Tissue, Brown, Animals, Electron Transport, Energy Metabolism, Intracellular Signaling Peptides and Proteins, Lipid Droplets, Lipid Metabolism, Male, Mice, Mice, Inbred C57BL, Mitochondria, Mitochondrial Dynamics, Mitochondrial Proteins, Muscle Proteins, Oxidation-Reduction, Pyruvic Acid, Thermogenesis, brown adipose tissue, lipid droplet, mitochondria, mitochondrial dynamics, peridroplet mitochondria, Medical Biochemistry and Metabolomics, Endocrinology & Metabolism, Biochemistry and cell biology, Medical biochemistry and metabolomics
Abstract

Mitochondria associate with lipid droplets (LDs) in fat-oxidizing tissues, but the functional role of these peridroplet mitochondria (PDM) is unknown. Microscopic observation of interscapular brown adipose tissue reveals that PDM have unique protein composition and cristae structure and remain adherent to the LD in the tissue homogenate. We developed an approach to isolate PDM based on their adherence to LDs. Comparison of purified PDM to cytoplasmic mitochondria reveals that (1) PDM have increased pyruvate oxidation, electron transport, and ATP synthesis capacities; (2) PDM have reduced β-oxidation capacity and depart from LDs upon activation of brown adipose tissue thermogenesis and β-oxidation; (3) PDM support LD expansion as Perilipin5-induced recruitment of mitochondria to LDs increases ATP synthase-dependent triacylglyceride synthesis; and (4) PDM maintain a distinct protein composition due to uniquely low fusion-fission dynamics. We conclude that PDM represent a segregated mitochondrial population with unique structure and function that supports triacylglyceride synthesis.

Published
2018

16. The Nutritional System

Author

Cinti, Saverio, Santy-Tomlinson, Julie, Series Editor, Falaschi, Paolo, Series Editor, Hertz, Karen, Series Editor, Geirsdóttir, Ólöf G., editor, and Bell, Jack J., editor

Published
2021
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18. The Italian law on body donation: A position paper of the Italian College of Anatomists

Author

De Caro, Raffaele, Boscolo-Berto, Rafael, Artico, Marco, Bertelli, Eugenio, Cannas, Mario, Cappello, Francesco, Carpino, Guido, Castorina, Sergio, Cataldi, Amelia, Cavaletti, Guido Angelo, Cinti, Saverio, Cocco, Lucio Ildebrando, Cremona, Ottavio, Crivellato, Enrico, De Luca, Antonio, Falconi, Mirella, Familiari, Giuseppe, Ferri, Gian Luca, Fornai, Francesco, Gesi, Marco, Geuna, Stefano, Gibelli, Daniele Maria, Giordano, Antonio, Gobbi, Pietro, Guerra, Germano, Gulisano, Massimo, Macchi, Veronica, Macchiarelli, Guido, Manzoli, Lucia, Michetti, Fabrizio, Miscia, Sebastiano, Montagnani, Stefania, Montella, Andrea Costantino Mario, Morini, Sergio, Onori, Paolo, Palumbo, Carla, Papa, Michele, Porzionato, Andrea, Quacci, Daniela Elena, Raspanti, Mario, Rende, Mario, Rezzani, Rita, Ribatti, Domenico, Ripani, Maurizio, Rodella, Luigi Fabrizio, Rossi, Pellegrino, Sbarbati, Andrea, Secchiero, Paola, Sforza, Chiarella, Stecco, Carla, Toni, Roberto, Vercelli, Alessandro, Vitale, Marco, Zancanaro, Carlo, Zauli, Giorgio, Zecchi, Sandra, Anastasi, Giuseppe Pio, and Gaudio, Eugenio

Published
2021
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22. Brown Fat Anatomy in Humans and Rodents

Author

Colleluori, Georgia, primary, Perugini, Jessica, additional, Di Vincenzo, Angelica, additional, Senzacqua, Martina, additional, Giordano, Antonio, additional, and Cinti, Saverio, additional

Published
2022
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23. The Adipose Organ

Author

Cinti, Saverio, Giordano, Antonio, Longhi, Sauro, editor, Monteriù, Andrea, editor, Freddi, Alessandro, editor, Aquilanti, Lucia, editor, Ceravolo, Maria Gabriella, editor, Carnevali, Oliana, editor, Giordano, Mario, editor, and Moroncini, Gianluca, editor

Published
2020
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39. Gastric ghrelin cells in obese patients are hyperactive

Author

Castorina, Sergio, Barresi, Vincenza, Luca, Tonia, Privitera, Giovanna, De Geronimo, Vincenzo, Lezoche, Giovanni, Cosentini, Ilaria, Di Vincenzo, Angelica, Barbatelli, Giorgio, Giordano, Antonio, Taus, Marina, Nicolai, Albano, Condorelli, Daniele Filippo, and Cinti, Saverio

Published
2021
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43. The Adipose Organ

Author

Cinti, Saverio, Lenzi, Andrea, Series Editor, Jannini, Emmanuele A., Series Editor, Sbraccia, Paolo, editor, and Finer, Nicholas, editor

Published
2019
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49. Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning

Author

Pellegrini, Camilla, Columbaro, Marta, Schena, Elisa, Prencipe, Sabino, Andrenacci, Davide, Iozzo, Patricia, Angela Guzzardi, Maria, Capanni, Cristina, Mattioli, Elisabetta, Loi, Manuela, Araujo-Vilar, David, Squarzoni, Stefano, Cinti, Saverio, Morselli, Paolo, Giorgetti, Assuero, Zanotti, Laura, Gambineri, Alessandra, and Lattanzi, Giovanna

Published
2019
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50. Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice

Author

de Jong, Jasper M. A., Sun, Wenfei, Pires, Nuno D., Frontini, Andrea, Balaz, Miroslav, Jespersen, Naja Z., Feizi, Amir, Petrovic, Katarina, Fischer, Alexander W., Bokhari, Muhammad Hamza, Niemi, Tarja, Nuutila, Pirjo, Cinti, Saverio, Nielsen, Søren, Scheele, Camilla, Virtanen, Kirsi, Cannon, Barbara, Nedergaard, Jan, Wolfrum, Christian, and Petrovic, Natasa

Published
2019
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