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1. Female Sex and Angiotensin-Converting Enzyme (ACE) Insertion/Deletion Polymorphism Amplify the Effects of Adiposity on Blood Pressure

Author

Chiriacò, Martina, primary, Tricò, Domenico, additional, Leonetti, Simone, additional, Petrie, John R., additional, Balkau, Beverley, additional, Højlund, Kurt, additional, Pataky, Zoltan, additional, Nilsson, Peter M, additional, Natali, Andrea, additional, Heine, R.J., additional, Dekker, J., additional, de Rooij, S., additional, Nijpels, G., additional, Boorsma, W., additional, Mitrakou, A., additional, Tournis, S., additional, Kyriakopoulou, K., additional, Thomakos, P., additional, Lalic, N., additional, Lalic, K., additional, Jotic, A., additional, Lukic, L., additional, Civcic, M., additional, Nolan, J., additional, Yeow, T.P., additional, Murphy, M., additional, DeLong, C., additional, Neary, G., additional, Colgan, M.P., additional, Hatunic, M., additional, Konrad, T., additional, Böhles, H., additional, Fuellert, S., additional, Baer, F., additional, Zuchhold, H., additional, Golay, A., additional, Harsch Bobbioni, E., additional, Barthassat, V., additional, Makoundou, V., additional, Lehmann, T.N.O., additional, Merminod, T., additional, Perry, C., additional, Neary, F., additional, MacDougall, C., additional, Shields, K., additional, Malcolm, L., additional, Laakso, M., additional, Salmenniemi, U., additional, Aura, A., additional, Raisanen, R., additional, Ruotsalainen, U., additional, Sistonen, T., additional, Laitinen, M., additional, Saloranta, H., additional, Coppack, S.W., additional, McIntosh, N., additional, Ross, J., additional, Pettersson, L., additional, Khadobaksh, P., additional, Laville, M., additional, Bonnet, F., additional, Brac de la Perriere, A., additional, Louche-Pelissier, C., additional, Maitrepierre, C., additional, Peyrat, J., additional, Beltran, S., additional, Serusclat, A., additional, Gabriel, R., additional, Sánchez, E.M., additional, Carraro, R., additional, Friera, A., additional, Novella, B., additional, Nilsson, P., additional, Persson, M., additional, Östling, G., additional, Melander, O., additional, Burri, P., additional, Piatti, P.M., additional, Monti, L.D., additional, Setola, E., additional, Galluccio, E., additional, Minicucci, F., additional, Colleluori, A., additional, Walker, M., additional, Ibrahim, I.M., additional, Jayapaul, M., additional, Carman, D., additional, Ryan, C., additional, Short, K., additional, McGrady, Y., additional, Richardson, D., additional, Beck-Nielsen, H., additional, Staehr, P., additional, Vestergaard, V., additional, Olsen, C., additional, Hansen, L., additional, Bolli, G.B., additional, Porcellati, F., additional, Fanelli, C., additional, Lucidi, P., additional, Calcinaro, F., additional, Saturni, A., additional, Ferrannini, E., additional, Muscelli, E., additional, Pinnola, S., additional, Kozakova, M., additional, Casolaro, A., additional, Astiarraga, B.D., additional, Mingrone, G., additional, Guidone, C., additional, Favuzzi, A., additional, Di Rocco, P., additional, Anderwald, C., additional, Bischof, M., additional, Promintzer, M., additional, Krebs, M., additional, Mandl, M., additional, Hofer, A., additional, Luger, A., additional, Waldhäusl, W., additional, Roden, M., additional, Dekker, J.M., additional, Mari, A., additional, Petrie, J., additional, Gaffney, P., additional, Boran, G., additional, Kok, A., additional, Patel, S., additional, Gastaldelli, A., additional, Ciociaro, D., additional, Guillanneuf, M.T., additional, Mhamdi, L., additional, Landucci, L., additional, Hills, S., additional, Mota, L., additional, Pacini, G., additional, Cavaggion, C., additional, Tura, A., additional, and Hills, S.A., additional

Published
2022
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2. Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk

Author

Kozakova, M. Gastaldelli, A. Morizzo, C. Højlund, K. Nilssson, P.M. Ferrannini, E. Heine, R.J. Dekker, J. de Rooij, S. Nijpels, G. Boorsma, W. Kok, A. Mitrakou, A. Tournis, S. Kyriakopoulou, K. Thomakos, P. Lalic, N. Lalic, K. Jotic, A. Lukic, L. Civcic, M. Nolan, J. Yeow, T.P. Murphy, M. DeLong, C. Neary, G. Colgan, M.P. Hatunic, M. Gaffney, P. Boran, G. Konrad, T. Böhles, H. Fuellert, S. Baer, F. Zuchhold, H. Golay, A. Bobbioni, E.H. Barthassat, V. Makoundou, V. Lehmann, T.N.O. Merminod, T. Petrie (now Dundee), J.R. Perry, C. Neary, F. MacDougall, C. Shields, K. Malcolm, L. Laakso, M. Salmenniemi, U. Aura, A. Raisanen, R. Ruotsalainen, U. Sistonen, T. Laitinen, M. Saloranta, H. Coppack, S.W. McIntosh, N. Ross, J. Pettersson, L. Khadobaksh, P. Balkau, B. Mhamdi, L. Guillanneuf, M.T. Laville, M. Bonnet, F. Brac de la Perriere, A. Louche-Pelissier, C. Maitrepierre, C. Peyrat, J. Beltran, S. Serusclat, A. Gabriel, R. Sánchez, E.M. Carraro, R. Friera, A. Novella, B. Nilssone, P. Persson, M. Östling, G. Melander, O. Burri, P. Piatti, P.M. Monti, L.D. Setola, E. Galluccio, E. Minicucci, F. Colleluori, A. Walker, M. Ibrahim, I.M. Jayapaul, M. Carman, D. Ryan, C. Short, K. McGrady, Y. Richardson, D. Patel, S. Beck-Nielsen, H. Staehr, P. Hojlundd, K. Vestergaard, V. Olsen, C. Hansen, L. Bolli, G.B. Porcellati, F. Fanelli, C. Lucidi, P. Calcinaro, F. Saturni, A. Ferranninia, E. Natali, A. Muscelli, E. Pinnola, S. Kozakovaa, M. Hills, S.A. Landucci, L. Mota, L. Gastaldelli, A. Ciociaro, D. Mari, A. Pacini, G. Cavaggion, C. Mingrone, G. Guidone, C. Favuzzi, A. Di Rocco, P. Anderwald, C. Bischof, M. Promintzer, M. Krebs, M. Mandl, M. Hofer, A. Luger, A. Waldhäusl, W. Roden, M. Palombo, C. RISC Investigators

Abstract

Plasma gamma-glutamyltransferase (GGT) was suggested to reflect the level of systemic oxidative stress. Oxidative stress induces changes in arterial structure and function and contributes to the development of hypertension. Therefore, GGT may be associated with arterial remodeling and blood pressure (BP) increment, even in absence of disease. To test this hypothesis, we evaluated, in 825 healthy subjects at low cardiometabolic risk, the associations of plasma GGT with carotid artery intima-media thickness (IMT), luminal diameter and prehypertension; in 154 subjects was evaluated also the association with aortic stiffness (cfPWV). Associations were controlled for insulin sensitivity, C-reactive protein, and life-style habits. In the main population, BP was remeasured after 3 years. Carotid diameter and cfPWV, but not IMT, were directly and independently related to plasma GGT. Subjects with prehypertension (N = 330) had higher GGT as compared with subjects with normal BP (22 [14] vs 17 [11] IU/L; adjusted P = 0.001), and within prehypertensive subjects, those who developed hypertension during 3 years had higher GGT than those without incident hypertension (27 [16] vs 21 [14] IU/L; adjusted P < 0.05). Within subjects with arterial stiffness measurement, those with prehypertension (N = 79) had higher both GGT and arterial stiffness (25 [14] vs 16 [20] IU/L and 9.11 ± 1.24 vs 7.90 ± 0.94 m/s; adjusted P < 0.01 and

Published
2021

7. Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk

Author

Kozakova, M., Gastaldelli, A., Morizzo, C., Hojlund, K., Nilssson, P. M., Ferrannini, E., Heine, R. J., Dekker, J., de Rooij, S., Nijpels, G., Boorsma, W., Kok, A., Mitrakou, A., Tournis, S., Kyriakopoulou, K., Thomakos, P., Lalic, N., Lalic, K., Jotic, A., Lukic, L., Civcic, M., Nolan, J., Yeow, T. P., Murphy, M., Delong, C., Neary, G., Colgan, M. P., Hatunic, M., Gaffney, P., Boran, G., Konrad, T., Bohles, H., Fuellert, S., Baer, F., Zuchhold, H., Golay, A., Bobbioni, E. H., Barthassat, V., Makoundou, V., Lehmann, T. N. O., Merminod, T., Petrie (now Dundee), J. R., Perry, C., Neary, F., Macdougall, C., Shields, K., Malcolm, L., Laakso, M., Salmenniemi, U., Aura, A., Raisanen, R., Ruotsalainen, U., Sistonen, T., Laitinen, M., Saloranta, H., Coppack, S. W., Mcintosh, N., Ross, J., Pettersson, L., Khadobaksh, P., Balkau, B., Mhamdi, L., Guillanneuf, M. T., Laville, M., Bonnet, F., Brac de la Perriere, A., Louche-Pelissier, C., Maitrepierre, C., Peyrat, J., Beltran, S., Serusclat, A., Gabriel, R., Sanchez, E. M., Carraro, R., Friera, A., Novella, B., Nilssone, P., Persson, M., Ostling, G., Melander, O., Burri, P., Piatti, P. M., Monti, L. D., Setola, E., Galluccio, E., Minicucci, F., Colleluori, A., Walker, M., Ibrahim, I. M., Jayapaul, M., Carman, D., Ryan, C., Short, K., Mcgrady, Y., Richardson, D., Patel, S., Beck-Nielsen, H., Staehr, P., Hojlundd, K., Vestergaard, V., Olsen, C., Hansen, L., Bolli, G. B., Porcellati, F., Fanelli, C., Lucidi, P., Calcinaro, F., Saturni, A., Ferranninia, E., Natali, A., Muscelli, E., Pinnola, S., Kozakovaa, M., Hills, S. A., Landucci, L., Mota, L., Ciociaro, D., Mari, A., Pacini, Giovanni, Cavaggion, C., Mingrone, Geltrude, Guidone, C., Favuzzi, Angela Maria Rita, Di Rocco, P., Anderwald, C., Bischof, M., Promintzer, M., Krebs, M., Mandl, M., Hofer, A., Luger, A., Waldhausl, W., Roden, M., Palombo, C., Pacini G., Mingrone G. (ORCID:0000-0003-2021-528X), Favuzzi A., Kozakova, M., Gastaldelli, A., Morizzo, C., Hojlund, K., Nilssson, P. M., Ferrannini, E., Heine, R. J., Dekker, J., de Rooij, S., Nijpels, G., Boorsma, W., Kok, A., Mitrakou, A., Tournis, S., Kyriakopoulou, K., Thomakos, P., Lalic, N., Lalic, K., Jotic, A., Lukic, L., Civcic, M., Nolan, J., Yeow, T. P., Murphy, M., Delong, C., Neary, G., Colgan, M. P., Hatunic, M., Gaffney, P., Boran, G., Konrad, T., Bohles, H., Fuellert, S., Baer, F., Zuchhold, H., Golay, A., Bobbioni, E. H., Barthassat, V., Makoundou, V., Lehmann, T. N. O., Merminod, T., Petrie (now Dundee), J. R., Perry, C., Neary, F., Macdougall, C., Shields, K., Malcolm, L., Laakso, M., Salmenniemi, U., Aura, A., Raisanen, R., Ruotsalainen, U., Sistonen, T., Laitinen, M., Saloranta, H., Coppack, S. W., Mcintosh, N., Ross, J., Pettersson, L., Khadobaksh, P., Balkau, B., Mhamdi, L., Guillanneuf, M. T., Laville, M., Bonnet, F., Brac de la Perriere, A., Louche-Pelissier, C., Maitrepierre, C., Peyrat, J., Beltran, S., Serusclat, A., Gabriel, R., Sanchez, E. M., Carraro, R., Friera, A., Novella, B., Nilssone, P., Persson, M., Ostling, G., Melander, O., Burri, P., Piatti, P. M., Monti, L. D., Setola, E., Galluccio, E., Minicucci, F., Colleluori, A., Walker, M., Ibrahim, I. M., Jayapaul, M., Carman, D., Ryan, C., Short, K., Mcgrady, Y., Richardson, D., Patel, S., Beck-Nielsen, H., Staehr, P., Hojlundd, K., Vestergaard, V., Olsen, C., Hansen, L., Bolli, G. B., Porcellati, F., Fanelli, C., Lucidi, P., Calcinaro, F., Saturni, A., Ferranninia, E., Natali, A., Muscelli, E., Pinnola, S., Kozakovaa, M., Hills, S. A., Landucci, L., Mota, L., Ciociaro, D., Mari, A., Pacini, Giovanni, Cavaggion, C., Mingrone, Geltrude, Guidone, C., Favuzzi, Angela Maria Rita, Di Rocco, P., Anderwald, C., Bischof, M., Promintzer, M., Krebs, M., Mandl, M., Hofer, A., Luger, A., Waldhausl, W., Roden, M., Palombo, C., Pacini G., Mingrone G. (ORCID:0000-0003-2021-528X), and Favuzzi A.

Abstract

Plasma gamma-glutamyltransferase (GGT) was suggested to reflect the level of systemic oxidative stress. Oxidative stress induces changes in arterial structure and function and contributes to the development of hypertension. Therefore, GGT may be associated with arterial remodeling and blood pressure (BP) increment, even in absence of disease. To test this hypothesis, we evaluated, in 825 healthy subjects at low cardiometabolic risk, the associations of plasma GGT with carotid artery intima-media thickness (IMT), luminal diameter and prehypertension; in 154 subjects was evaluated also the association with aortic stiffness (cfPWV). Associations were controlled for insulin sensitivity, C-reactive protein, and life-style habits. In the main population, BP was remeasured after 3 years. Carotid diameter and cfPWV, but not IMT, were directly and independently related to plasma GGT. Subjects with prehypertension (N = 330) had higher GGT as compared with subjects with normal BP (22 [14] vs 17 [11] IU/L; adjusted P = 0.001), and within prehypertensive subjects, those who developed hypertension during 3 years had higher GGT than those without incident hypertension (27 [16] vs 21 [14] IU/L; adjusted P < 0.05). Within subjects with arterial stiffness measurement, those with prehypertension (N = 79) had higher both GGT and arterial stiffness (25 [14] vs 16 [20] IU/L and 9.11 ± 1.24 vs 7.90 ± 0.94 m/s; adjusted P < 0.01 and <0.05). In the view of previous evidence linking plasma GGT concentration to the level of systemic oxidative stress, our findings suggest a role of oxidative stress in subclinical arterial damage and in prehypertension, even in healthy subjects free of cardiometabolic risk. Arterial organ damage may represent the link between GGT and hypertension.

Published
2020

8. Circulating palmitoleic acid is an independent determinant of insulin sensitivity, beta cell function and glucose tolerance in non-diabetic individuals: a longitudinal analysis

Author

Trico, D, Mengozzi, A, Nesti, L, Hatunic, M, Sanchez, Rg, Konrad, T, Lalic, K, Lalic, Nm, Mari, A, Natali, A, Heine, Rj, Dekker, J, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Bohles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Bobbioni, Eh, Barthassat, V, Makoundou, V, Lehmann, Tno, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, de la Perriere, Ab, Louche-Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sanchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Ostling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, I, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Beck-Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, F, Fanelli, C, Lucidi, P, Calcinaro, F, Saturni, A, Ferrannini, E, Muscelli, E, Pinnola, S, Kozakova, M, Casolaro, A, Astiarraga, Bd, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhausl, W, Roden, M, Balkau, B, Dekker, Jm, Petrie, J, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Landucci, L, Hills, S, Mota, L, Pacini, G, Cavaggion, C, Tura, A, Hills, Sa, and Mota, L.

Subjects
Adult, Blood Glucose, Male, 0301 basic medicine, medicine.medical_specialty, Subcutaneous adipose tissue, Endocrinology, Diabetes and Metabolism, Adipose tissue, 030209 endocrinology & metabolism, Carbohydrate metabolism, Palmitate, NEFA, Fatty Acids, Monounsaturated, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Insulin resistance, Insulin-Secreting Cells, Internal medicine, Adipokine, Internal Medicine, medicine, Humans, Palmitoleic acid, Longitudinal Studies, Monounsaturated fatty acid, Lipokine, Beta cell function, Glucose tolerance, Metabolism, Glucose Tolerance Test, Middle Aged, medicine.disease, Insulin sensitivity, Cross-Sectional Studies, 030104 developmental biology, Endocrinology, chemistry, Body Composition, Female, Insulin Resistance, Hormone
Abstract

Experimental studies suggest that the fatty acid palmitoleate may act as an adipocyte-derived lipid hormone (or ‘lipokine’) to regulate systemic metabolism. We investigated the relationship of circulating palmitoleate with insulin sensitivity, beta cell function and glucose tolerance in humans. Plasma NEFA concentration and composition were determined in non-diabetic individuals from the Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) study cohort at baseline (n = 1234) and after a 3 year follow-up (n = 924). Glucose tolerance, insulin secretion and beta cell function were assessed during an OGTT. Whole-body insulin sensitivity was measured by a hyperinsulinaemic–euglycaemic clamp (M/I) and OGTT (oral glucose insulin sensitivity index [OGIS]). The liver insulin resistance index was calculated using clinical and biochemical data. Body composition including fat mass was determined by bioelectrical impedance. Circulating palmitoleate was proportional to fat mass (r = 0.21, p < 0.0001) and total NEFA levels (r = 0.19, p < 0.0001). It correlated with whole-body insulin sensitivity (M/I: standardised regression coefficient [std. β] = 0.16, p < 0.0001), liver insulin resistance (std. β = −0.14, p < 0.0001), beta cell function (potentiation: std. β = 0.08, p = 0.045) and glucose tolerance (2 h glucose: std. β = −0.24, p < 0.0001) after adjustment for age, sex, BMI, adiposity and other NEFA. High palmitoleate concentrations prevented the decrease in insulin sensitivity associated with excess palmitate (p = 0.0001). In a longitudinal analysis, a positive independent relationship was observed between changes in palmitoleate and insulin sensitivity over time (std. β = 0.07, p = 0.04). We demonstrated that plasma palmitoleate is an independent determinant of insulin sensitivity, beta cell function and glucose tolerance in non-diabetic individuals. These results support the role of palmitoleate as a beneficial lipokine released by adipose tissue to prevent the negative effects of adiposity and excess NEFA on systemic glucose metabolism.

Published
2019

10. The LIFE PERSUADED project approach on phthalates and bisphenol A biomonitoring in Italian mother-child pairs linking exposure and juvenile diseases

Author

La Rocca, C, Maranghi, F, Tait, S, Tassinari, R, Baldi, F, Bottaro, G, Buzzigoli, E, Carli, F, Cianfarani, S, Conte, R, Deodati, A, Gastaldelli, A, Pala, Ap, Raffaelli, A, Saponaro, C, Scire, G, Spadoni, Gl, Busani, L, Narciso, L, Baldiniferroli, B, Marini, R, Germani, D, Barsotti, G, Ciociaro, D, Dellalatta, V, Distante, G, Gaggini, M, Landi, P, Di Virgilio, A, Martinelli, A, Valeri, M, Mancini, Fr, Fabbrizi, E, and Toffol, G

Subjects
0301 basic medicine, Male, Pediatric Obesity, Multivariate analysis, Health, Toxicology and Mutagenesis, Puberty, Precocious, Urine, 010501 environmental sciences, Endocrine Disruptors, 01 natural sciences, Surveys and Questionnaires, BPA, Children obesity, DEHP, Human biomonitoring, In vivo toxicity, Puberty, Adolescent, Adult, Animals, Benzhydryl Compounds, Child, Child, Preschool, Environmental Exposure, Environmental Monitoring, Environmental Pollutants, Epidemiologic Studies, Female, Humans, Italy, Life Style, Mothers, Phenols, Phthalic Acids, Rats, education.field_of_study, General Medicine, Pollution, Settore MED/38, Risk assessment, endocrine system, Population, 03 medical and health sciences, Environmental health, medicine, Environmental Chemistry, Precocious puberty, Endocrine system, Juvenile, education, Preschool, 0105 earth and related environmental sciences, business.industry, medicine.disease, Obesity, 030104 developmental biology, Precocious, business
Abstract

Phthalates and bisphenol A (BPA), plasticizers used in several products of daily life, are considered as endocrine disrupters, therefore children exposure is particularly relevant. The LIFE PERSUADED project aims to define the following: (a) the evaluation of internal levels of DEHP's metabolites and BPA in Italian children and their mothers, (b) the association of the exposure with puberty development and obesity diseases, and (c) the effects of exposure in juvenile in vivo model. The cross-sectional study has involved 2160 mother-child pairs, including males and females, children and adolescents, from urban and rural areas of North, Center, and South Italy. A structured questionnaire and a food diary are designed to evaluate the association between lifestyle variables potentially related to DEHP/BPA exposure and internal levels, through univariate and multivariate analyses. Two pilot case-control studies are carried out on idiopathic premature thelarche and precocious puberty (30 girls each group, aged 2-7 years) and idiopathic obesity (30 boys and 30 girls, aged 6-10 years), matched to healthy controls. BPA and DEHP's metabolites are analyzed in urine samples from all recruited subjects. Clinical and toxicological biomarkers are evaluated in serum of case-control subjects. Moreover, the toxicity study is carried out in a juvenile rodent model exposed to mixtures of BPA and DEHP at dose levels recorded in children population. The scientific results of LIFE PERSUADED will contribute to risk assessment of BPA and DEHP.

Published
2018

11. In non obese NAFLD increased plasma saturated fatty acids and insulin resistance are metabolic signatures of severity of liver disease

Author

Carli, F., primary, Gaggini, M., additional, Rosso, C., additional, Saponaro, C., additional, Barbieri, C., additional, Latta, V.D., additional, Buzzigoli, E., additional, Ciociaro, D., additional, Abate, M.L., additional, Marietti, M., additional, Younes, R., additional, Bugianesi, E., additional, and Gastaldelli, A., additional

Published
2018
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12. Insulin sensitivity and carotid intima-media thickness: relationship between insulin sensitivity and cardiovascular risk study

Author

Kozakova, M, Natali, A, Dekker, J, Beck Nielsen, H, Laakso, M, Nilsson, P, Balkau, B, Ferrannini, E, Heine, Rj, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie Dundee JR, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Persson, M, Östling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Geremia Brunetto, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, Filippo, Saturni, A, Muscelli, E, Pinnola, S, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, Dekker, Ferrannini, Mari, A, Natali, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Mota, L, Pacini, G, Cavaggion, C, Hills, Sa, Landucci, L, Mota, L., Epidemiology and Data Science, and EMGO - Lifestyle, overweight and diabetes

Subjects
Adult, Blood Glucose, Carotid Artery Diseases, Male, medicine.medical_specialty, Adipokine, Carotid Intima-Media Thickness, Risk Assessment, Sensitivity and Specificity, Cohort Studies, Insulin resistance, Age Distribution, Adipokines, Diabetes mellitus, Internal medicine, medicine.artery, medicine, Humans, Common carotid artery, cardiovascular diseases, Sex Distribution, Retrospective Studies, business.industry, Incidence, Fatty Acids, Insulin sensitivity, Cholesterol, LDL, Glucose Tolerance Test, Middle Aged, medicine.disease, Prognosis, Endocrinology, Intima-media thickness, Cardiovascular Diseases, Cohort, Glucose Clamp Technique, cardiovascular system, Female, Insulin Resistance, Cardiology and Cardiovascular Medicine, business, Dyslipidemia
Abstract

Objective— Despite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man has not been demonstrated. Approach and Results— We studied a European cohort of 525 men and 655 women (mean age, 44±8 years) free of conditions known to affect carotid wall (diabetes mellitus, hypertension, and dyslipidemia). All subjects received an oral glucose tolerance test, a euglycemic hyperinsulinemic clamp (M/I as a measure of insulin sensitivity), and B-mode carotid ultrasound. In 833 participants (380 men), the carotid ultrasound was repeated after 3 years. In men, baseline intima-media thickness in the common carotid artery (CCA-IMT) was significantly higher ( P P Conclusions— In young-to-middle aged apparently healthy people, the association of CCA-IMT with insulin sensitivity and its metabolic correlates differs between men and women. Lower insulin sensitivity is associated with higher IMT only in men; this association seems to be mediated by circulating free fatty acids and adipocytokines. In women, CCA-IMT is independently associated with fasting plasma glucose.

Published
2013
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13. Fasting insulin has a stronger association with an adverse cardiometabolic risk profile than insulin resistance: the RISC study

Author

de Rooij SR, Dekker, Jm, Kozakova, M, Mitrakou, A, Melander, O, Gabriel, R, Guidone, C, Højlund, K, Murphy, Ms, Nijpels, G, Dekker, J, de Rooij, S, Boorsma, P, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Raisanen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, S, Sánchez, Me, Carraro, R, Friera, A, Perez, S, Nilsson, P, Persson, M, Ostling, G, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Mingrone, G, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofe, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, B, Mari, A, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Landucci, L, Hills, S, Mota, L, Pacini, G, Cavaggion, C, Hills, Sa, Mota, Epidemiology and Data Science, General practice, and EMGO - Lifestyle, overweight and diabetes

Subjects
Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Cohort Studies, Endocrinology, Insulin resistance, Internal medicine, Prevalence, medicine, Hyperinsulinemia, Humans, Insulin, Ultrasonography, Metabolic Syndrome, Glucose tolerance test, medicine.diagnostic_test, business.industry, Metabolic Syndrome X, Fasting, General Medicine, Odds ratio, Glucose Tolerance Test, Middle Aged, Glucose clamp technique, medicine.disease, Cardiovascular Diseases, Europe, Female, Glucose Clamp Technique, Insulin Resistance, Tunica Media, Intima-media thickness, Metabolic syndrome, business
Abstract

ObjectiveFasting insulin concentrations are often used as a surrogate measure of insulin resistance. We investigated the relative contributions of fasting insulin and insulin resistance to cardiometabolic risk and preclinical atherosclerosis.Design and methodsThe Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) cohort consists of 1326 European non-diabetic, overall healthy men and women aged 30–60 years. We performed standard oral glucose tolerance tests and hyperinsulinemic euglycemic clamps. As a general measure of cardiovascular risk, we assessed the prevalence of the metabolic syndrome in 1177 participants. Carotid artery intima media thickness (IMT) was measured by ultrasound to assess preclinical atherosclerosis.ResultsFasting insulin was correlated with all elements of the metabolic syndrome. Insulin sensitivity (M/I) was correlated with most elements. The odds ratio for the metabolic syndrome of those in the highest quartile of fasting insulin compared with those in the lower quartiles was 5.4 (95% confidence interval (CI) 2.8–10.3, adjusted for insulin sensitivity) in men and 5.1 (2.6–9.9) in women. The odds ratio for metabolic syndrome of those with insulin sensitivity in the lowest quartile of the cohort compared with those in the higher quartiles was 2.4 (95% CI 1.3–4.7, adjusted for fasting insulin) in men and 1.6 (0.8–3.1) in women. Carotid IMT was only statistically significantly associated with fasting insulin in both men and women.ConclusionsFasting insulin, a simple and practical measure, may be a stronger and independent contributor to cardiometabolic risk and atherosclerosis in a healthy population than hyperinsulinemic euglycemic clamp-derived insulin sensitivity.

Published
2009
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14. Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population

Author

Gastaldelli, A., Kozakova, M., Hojlund, K., Flyvbjerg, A., Favuzzi, A., Mitrakou, A., Balkau, B., Heine, R. J., Dekker, J., Nijpels, G., Boorsma, W., Tournis, S., Kyriakopoulou, K., Thomakos, P., Lalic, N., Lalic, K., Jotic, A., Lukic, L., Civcic, M., Nolan, J., Yeow, T. P., Murphy, M., Delong, C., Neary, G., Colgan, M. P., Hatunic, M., Konrad, T., Bohles, H., Fuellert, S., Baer, F., Zuchhold, H., Golay, A., Harsch Bobbioni, E., Barthassat, V., Makoundou, V., Lehmann, T. N. O., Merminod, T., Petrie, J. R., Perry, C., Neary, F., Macdougall, C., Shields, K., Malcolm, L., Laakso, M., Salmenniemi, U., Aura, A., Raisanen, R., Ruotsalainen, U., Sistonen, T., Laitinen, M., Saloranta, H., Coppack, S. W., Mcintosh, N., Khadobaksh, P., Laville, M., Bonnet, F., Brac de la Perriere, A., Louche-Pelissier, C., Maitrepierre, C., Peyrat, J., Serusclat, A., Gabriel, R., Sanchez, E. M., Carraro, R., Friera, A., Novella, B., Nilsson, P., Persson, M., Oostling, G., Melander, O., Burri, P., Piatti, P. M., Monti, L. D., Setola, E., Galluccio, E., Minicucci, F., Colleluori, A., Walker, M., Ibrahim, I. M., Jayapaul, M., Carman, D., Short, K., Mcgrady, Y., Richardson, D., Beck-Nielsen, H., Staehr, P., Vestergaard, V., Olsen, C., Hansen, L., Bolli, G. B., Porcellati, F., Fanelli, C., Lucidi, P., Calcinaro, F., Saturni, A., Ferrannini, E., Natali, A., Muscelli, E., Pinnola, S., Mingrone, G., Guidone, C., Di Rocco, P., Anderwald, C., Bischof, M., Promintzer, M., Krebs, M., Mandl, M., Hofer, A., Luger, A., Waldhaausl, W., Roden, M., Dekker, J. M., Mari, A., Gaffney, P., Boran, G., Kok, A., Patel, S., Ciociaro, D., Guillanneuf, M. T., Mhamdi, L., Pacini, G., Cavaggion, C., Hills, S. A., Landucci, L., Mota, L., Epidemiology and Data Science, Internal medicine, General practice, and EMGO - Lifestyle, overweight and diabetes

Subjects
Adult, Male, medicine.medical_specialty, Carotid Artery, Common, Coronary Disease, Impaired glucose tolerance, Framingham Heart Study, Insulin resistance, Risk Factors, Internal medicine, Diabetes mellitus, Humans, Medicine, Prospective Studies, Risk factor, Ultrasonography, Hepatology, Adiponectin, business.industry, Fatty liver, Middle Aged, Atherosclerosis, medicine.disease, Common, Europe, Fatty Liver, Endocrinology, Female, Insulin Resistance, Intima-media thickness, Carotid Artery, business
Abstract

Udgivelsesdato: 2009-May Patients with fatty liver (FL) disease have a high risk of developing diabetes and cardiovascular diseases. The aim was to evaluate the association between FL, insulin resistance (IR), coronary heart disease (CHD) risk, and early atherosclerosis in a large European population (RISC Study). In 1,307 nondiabetic subjects (age 30-60 years) recruited at 19 centers, we evaluated liver enzymes, lipids, insulin sensitivity (by euglycemic-hyperinsulinemic clamp), glucose tolerance (by 75 g oral glucose tolerance test), carotid atherosclerosis as intima media thickness (IMT), CHD risk by the Framingham Heart study prediction score, and physical activity (by accelerometer). The presence of FL was estimated using the fatty liver index (FLI; >60, likelihood >78% presence FL; FLI 91% absence of FL). Subjects were divided into three groups: G1: FLI 60 (n = 234), G2: intermediate group (n = 465). Compared to G1, G3 included more men (70% versus 24%) and people with impaired glucose tolerance (23% versus 5%). IMT increased with FLI (G3 = 0.64 +/- 0.08 versus G1 = 0.58 +/- 0.08 mm, P < 0.0001). FLI was associated with increased CHD risk (r = 0.48), low-density lipoprotein cholesterol (r = 0.33), alanine aminotransferase (r = 0.48), aspartate aminotransferase (r = 0.25), systolic blood pressure (r = 0.39) and IMT (r = 0.30), and reduced insulin sensitivity (r = -0.43), high-density lipoprotein cholesterol (r = -0.50), adiponectin (r = -0.42), and physical activity (r = -0.16, all P < 0.0001). The correlations hold also in multivariate analysis after adjusting for age, gender, and recruiting center. Conclusion: In middle-age nondiabetic subjects, increased IMT, CHD risk, and reduced insulin sensitivity are associated with high values of FLI.

Published
2009
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16. Increased hepatic glucose production and insulin resistance are associated to increased plasma concentrations of glucogenic amino acids in subjects with NAFLD

Author

Gaggini, M., primary, Rosso, C., additional, Carli, F., additional, Della Latta, V., additional, Ciociaro, D., additional, Marietti, M., additional, Buzzigoli, E., additional, Abate, M.L., additional, Gambino, R., additional, Cassader, M., additional, Smedile, A., additional, Bugianesi, E., additional, and Gastaldelli, A., additional

Published
2017
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17. Obesity and carotid artery remodeling

Author

Kozakova, M., Palombo, C., Morizzo, C., Hojlund, K., Hatunic, M., Balkau, B., Nilsson, P. M., Ferrannini, E., Heine, R. J., Dekker, J., De Rooij, S., Nijpels, G., Boorsma, W., Mitrakou, A., Tournis, S., Kyriakopoulou, K., Thomakos, P., Lalic, N., Lalic, K., Jotic, A., Lukic, L., Civcic, M., Nolan, J., Yeow, T. P., Murphy, M., Delong, C., Neary, G., Colgan, M. P., Konrad, T., Bohles, H., Fuellert, S., Baer, F., Zuchhold, H., Golay, A., Bobbioni, E. H., Barthassat, V., Makoundou, V., Lehmann, T. N. O., Merminod, T., Petrie, J. R., Perry, C., Neary, F., Macdougall, C., Shields, K., Malcolm, L., Laakso, M., Salmenniemi, U., Aura, A., Raisanen, R., Ruotsalainen, U., Sistonen, T., Laitinen, M., Saloranta, H., Coppack, S. W., Mcintosh, N., Angel, ROSS JOHN, Pettersson, L., Khadobaksh, P., Laville, M., Bonnet, F., De La Perriere, A. B., Louche-Pelissier, C., Maitrepierre, C., Peyrat, J., Beltran, S., Serusclat, A., Gabriel, R., Sanchez, E. M., Carraro, R., Friera, A., Novella, B., Nilsson, P., Persson, M., Ostling, G., Melander, O., Burri, P., Piatti, P. M., Monti, L. D., Setola, E., Galluccio, E., Minicucci, F., Colleluori, A., Walker, M., Ibrahim, I. M., Jayapaul, M., Carman, D., Ryan, C., Short, K., Mcgrady, Y., Richardson, D., Beck-Nielsen, H., Staehr, P., Vestergaard, V., Olsen, C., Hansen, L., Bolli, G. B., Porcellati, F., Fanelli, C., Lucidi, P., Calcinaro, F., Saturni, A., Natali, A., Muscelli, E., Pinnola, S., Mingrone, G., Guidone, C., Favuzzi, A., Di Rocco, P., Anderwald, C., Bischof, M., Promintzer, M., Krebs, M., Mandl, M., Hofer, A., Luger, A., Waldhausl, W., Roden, M., Dekker, J. M., Mari, A., Gaffney, P., Boran, G., Kok, A., Patel, S., Gastaldelli, A., Ciociaro, D., Guillanneuf, M. T., Mhamdi, L., Mota, L., Pacini, G., Cavaggion, C., Hills, S. A., Landucci, L., Internal medicine, Dermatology, Epidemiology and Data Science, CCA - Immuno-pathogenesis, EMGO - Lifestyle, overweight and diabetes, and General practice

Subjects
Pathology, medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Carotid arteries, Carotid remodeling, Hemodynamics, Stroke volume, medicine.disease, Obesity, Obesity, Carotid remodeling, Ultrasound, Blood pressure, Diabetes mellitus, Ultrasound, Internal Medicine, medicine, cardiovascular system, Cardiac and Cardiovascular Systems, Original Article, cardiovascular diseases, Metabolic syndrome, business, Body mass index
Abstract

Background/Objective: The present study tested the hypothesis that obesity-related changes in carotid intima-media thickness (IMT) might represent not only preclinical atherosclerosis but an adaptive remodeling meant to preserve circumferential wall stress (CWS) in altered hemodynamic conditions characterized by body size-dependent increase in stroke volume (SV) and blood pressure (BP). Subjects/Methods: Common carotid artery (CCA) luminal diameter (LD), IMT and CWS were measured in three different populations in order to study: (A) cross-sectional associations between SV, BP, anthropometric parameters and CCA LD (266 healthy subjects with wide range of body weight (24–159 kg)); (B) longitudinal associations between CCA LD and 3-year IMT progression rate (ΔIMT; 571 healthy non-obese subjects without increased cardiovascular (CV) risk); (C) the impact of obesity on CCA geometry and CWS (88 obese subjects without CV complications and 88 non-obese subjects matched for gender and age). Results: CCA LD was independently associated with SV that was determined by body size. In the longitudinal study, baseline LD was an independent determinant of ΔIMT, and ΔIMT of subjects in the highest LD quartile was significantly higher (28±3 μm) as compared with those in the lower quartiles (8±3, 16±4 and 16±3 μm, P=0.001, PP=0.01, respectively). In addition, CCA CWS decreased during the observational period in the highest LD quartile (from 54.2±8.6 to 51.6±7.4 kPa, PPP=0.05) due to a significant increase in IMT (P=0.005 after adjustment for confounders). Conclusions: Our findings suggest that in obese subjects, the CCA wall thickens to compensate the luminal enlargement caused by body size-induced increase in SV, and therefore, to normalize the wall stress. CCA diameter in obesity could represent an additional biomarker, depicting the impact of altered hemodynamics on arterial wall.

Published
2015
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20. Increased hepatic glucose production and insulin resistance in subjects with non-alcoholic fatty liver disease is associated to increased plasma concentrations of glucogenic amino acids

Author

Gaggini, M., primary, Carli, F., additional, Rosso, C., additional, Latta, V.D., additional, Ciociaro, D., additional, Marietti, M., additional, Buzzigoli, E., additional, Abate, M.L., additional, Gambino, R., additional, Cassader, M., additional, Smedile, A., additional, Bugianesi, E., additional, and Gastaldelli, A., additional

Published
2017
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21. Alteration in lipid metabolism after an oral fat load in patients with NAFLD

Author

Mezzabotta, Lavinia, Vanni, Ester, Rosso, Chiara, Gaggini, M., Gambino, Roberto, Buzzigoli, E., Saponaro, C., Ciociaro, D., Abate, Maria Lorena, Saba, F., Salomone, F., Caviglia, GIAN PAOLO, Carenzi, Silvia, Smedile, Antonina, Rizzetto, Mario, Cassader, Maurizio, Gastaldelli, A., and Bugianesi, Elisabetta

Published
2014

25. From metabolic normality to cardiometabolic risk factors in subjects with obesity

Author

Elisabetta Bobbioni Harsch, Zoltan, Pataky, Vincent, Makoundou, Martine, Laville, Emmanuel, Disse, Christian, Anderwald, Thomas, Konrad, Alain, Golay, Heine, Rj, Dekker, J, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Pataky, Z, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Östling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Geremia Brunetto, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, B, Dekker, Jm, Mari, A, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Pacini, G, Cavaggion, C, Hills, Sa, Landucci, L, and Mota, L.

Subjects
Adult, Male, medicine.medical_specialty, Obesity, cardiometabolic risk factors, Carotid Artery, Common, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Blood Pressure, Overweight, Carotid Intima-Media Thickness, Body Mass Index, Impaired glucose tolerance, Young Adult, Endocrinology, Insulin resistance, Reference Values, Risk Factors, Internal medicine, Glucose Intolerance, medicine, Humans, Obesity, ddc:613, Nutrition and Dietetics, business.industry, Body Weight, Fasting, Middle Aged, medicine.disease, Impaired fasting glucose, Blood pressure, Cardiovascular Diseases, lipids (amino acids, peptides, and proteins), Female, medicine.symptom, Insulin Resistance, business, Lipoproteins, HDL, Body mass index, Weight gain
Abstract

The aim of the study was to evaluate the 3 years incidence of cardiometabolic risk factors, such as impaired fasting glucose, reduced high-density lipoprotein (HDL)-cholesterol, increased plasma triglycerides or blood pressure as well as impaired glucose tolerance in overweight or obese (ow/ob) and normal body weight (nbw) subjects metabolically normal at baseline. Subjects from the Relationship between Insulin Sensitivity and Cardiovascular Disease (RISC) study were analyzed. We analyzed 284 nbw and 152 ow/ob subjects who, at baseline, did not show any of the above-mentioned cardiometabolic risk factors. At 3 years, these parameters were re-evaluated. Intima-media thickness (IMT) of the common carotid artery (CCA) was echographically measured. At follow-up, the incidence of one or more cardiometabolic risk factors was 57.2% in ow/ob vs. 31.7% in nbw (P < 0.0001). After adjustment for age, sex, menopause status, lifestyle parameters, insulin sensitivity, and fasting insulinemia, BMI remained significantly linked to the development of one or more cardiometabolic risk factors (P = 0.02). An increased BMI at follow-up was significantly associated with the development of cardiometabolic alterations, in both nbw and ow/ob groups (P = 0.04). Ow/ob subjects who, at 3 years follow-up, remained metabolically normal, showed a less favourable cardiometabolic profile, when compared to nbw counterparts. In ow/ob metabolically normal males and females, intima-media of the common carotid at follow-up was thicker than in nbw (P = 0.03 for males, P = 0.04 for females). In conclusion, metabolically normal obese subjects show a higher incidence of cardiometabolic risk factors, in a short follow-up period. Weight gain is significantly associated with the development of these factors, in both nbw and ow/ob subjects.

Published
2012

26. Fatty liver index, gamma-glutamyltransferase, and early carotid plaques

Author

Kozakova, M, Palombo, C, Eng, Mp, Dekker, J, Flyvbjerg, A, Mitrakou, A, Gastaldelli, A, Ferrannini, E, Heine, Rj, Dekker, Jm, de Rooij, S, Nijpels, G, Boorsma, W, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Bobbioni Harsch, E, Barthassat, V, Makoundou, V, Lehmann, T, Merminod, T, Petrie, J, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, de la Perriere AB, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Me, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Östling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Natali, A, Muscelli, E, Pinnola, S, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, B, Mari, A, Gaffney, P, Boran, G, Beck Nielsen, H, Kok, A, Patel, S, Ciociaro, D, Guillanneuf, Mt, Mota, L, Pacini, G, Cavaggion, C, Hills, Sa, Landucci, L, Mota, L., Epidemiology and Data Science, and EMGO - Lifestyle, overweight and diabetes

Subjects
Carotid Artery Diseases, Male, SMOOTH-MUSCLE-CELLS, Comorbidity, INTIMA-MEDIA THICKNESS, Severity of Illness Index, ADIPONECTIN, AMERICAN-HEART-ASSOCIATION, Prevalence, Gamma-glutamyltransferase, Ultrasonography, RISK, biology, INSULIN SENSITIVITY, Fatty liver, gamma-Glutamyltransferase, Middle Aged, Prognosis, Plaque, Atherosclerotic, Survival Rate, CARDIOVASCULAR-DISEASE, Hypertension, Female, Waist Circumference, Adult, medicine.medical_specialty, HEPATIC STEATOSIS, PLASMA-PROTEIN, ATHEROSCLEROSIS, Risk Assessment, Insulin resistance, Age Distribution, Internal medicine, Diabetes mellitus, medicine, Humans, Sex Distribution, Proportional Hazards Models, Hepatology, Adiponectin, business.industry, medicine.disease, Fatty Liver, Endocrinology, Cross-Sectional Studies, Logistic Models, Intima-media thickness, Multivariate Analysis, biology.protein, Metabolic syndrome, Insulin Resistance, business, Dyslipidemia
Abstract

An association between fatty liver and carotid atherosclerosis has been established; however, it is not clear whether this relationship is a consequence of shared conventional risk factors or whether it is determined by specific circulating factors originating from liver or adipose tissue. To identify the factors possibly linking fatty liver and atherosclerosis, we assessed, in 1,012 subjects free of confounding diseases (e.g., hypertension, diabetes, cardiovascular diseases, and dyslipidemia) and metabolic syndrome, the relationship between the presence of early plaques at carotid bifurcation and fatty liver index (FLI; a validated surrogate marker of fatty liver), as well as the associations between carotid plaque presence and established atherosclerotic risk factors, family history of cardiovascular disease (FH-CVD) or diabetes, insulin sensitivity, serum liver enzymes, adipokines, fatty free acids, and high-sensitivity C-reactive protein (hsCRP). A total of 55 of 1,012 subjects (5.4%) had small plaque at carotid bifurcation. Subjects with plaque were older and had higher prevalence of FLI ≥60 and FH-CVD, higher blood pressure, plasma low-density lipoprotein cholesterol, glucose, gamma-glutamyltransferase (GGT), and hsCRP, as compared to subjects without plaques (P < 0.05). In a logistic regression model, adjusted for sex, liver transaminase, and alcohol consumption, the independent predictors of plaque presence were age (P < 0.0005), FLI ≥60 (P < 0.0005), and current smoking (P < 0.05). When FLI in the model was replaced by variables used in its equation (e.g., body mass index, waist circumference, plasma triglycerides, and GGT), the independent determinants of plaque presence were age (P < 0.001), GGT (P = 0.001), and current smoking (P < 0.05). Conclusions: Our cross-sectional study suggests that subjects with FLI ≥60 are at higher risk of atherosclerotic lesions, independently of established risk factors, and that serum GGT may represent a link between fatty liver and the development of early atherosclerosis. (HEPATOLOGY 2012)

Published
2012
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27. Impact of increased visceral and cardiac fat on cardiometabolic risk and disease

Author

Sironi, A. M., Petz, R., Marchi, D. D., Buzzigoli, E., Ciociaro, D., Positano, V., Lombardi, M., Ferrannini, Eleuterio, and Gastaldelli, A.

Subjects
Male, Metabolic Syndrome, Metabolic Syndrome X, Great Britain, Blood Pressure, Glucose Tolerance Test, Intra-Abdominal Fat, Middle Aged, Blood Pressure, Body Fat Distribution, Body Mass Index, Cardiovascular Diseases, epidemiology/metabolism/pathology, Female, Glucose Tolerance Test, Great Britain, epidemiology, Humans, Insulin Resistance, Intra-Abdominal Fat, pathology, Magnetic Resonance Imaging, Male, Metabolic Syndrome X, epidemiology/metabolism/pathology, Middle Aged, Pericardium, pathology/physiopathology, Risk Factors, Magnetic Resonance Imaging, United Kingdom, Body Mass Index, epidemiology/metabolism/pathology, pathology/physiopathology, Cardiovascular Diseases, Risk Factors, Body Fat Distribution, Humans, epidemiology, pathology, Female, Insulin Resistance, Pericardium
Abstract

Previous studies have highlighted the associations between abdominal, cardiac or total fat accumulation and cardiovascular disease. The aim of this study was to investigate the impact of different ectopic fat depots on measurements of metabolic dysfunction and cardiovascular disease risk.Using magnetic resonance imaging in 113 subjects, we measured abdominal (visceral and subcutaneous) and cardiac (epicardial and extra-pericardial) fat depots and examined their association with overall (BMI) and abdominal obesity (waist circumference), dyslipidaemia (triglycerides, total and HDL cholesterol), glucose tolerance (by an oral glucose tolerance test) and insulin sensitivity, blood pressure and 10-year coronary heart disease risk by Framingham score.Fat accumulation was proportional to the degree of obesity, with body fat ranging from 14 to 33 kg, visceral fat from 0.8 to 1.8 kg and cardiac fat from 134 to 236 g. Most cardiac fat (70% on average) was extra-pericardial, with a wide variability for both cardiac depots (epicardial: 172-2008 mm(2); extra-pericardial: 100-5056 mm(2)). Only visceral and extra-pericardial fat, but not epicardial or subcutaneous fat, could discriminate between subjects with three or more factors of the metabolic syndrome or medium-to-high coronary heart disease risk score. Controlling for gender and BMI by multivariable analysis, the best marker of reduced insulin sensitivity was visceral fat (partial r = -0.35); extra-pericardial fat was the closest associate of increased blood pressure (partial r = 0.26) and both extra-pericardial and visceral fat clustered with hypertriglyceridaemia (partial r = 0.29 and 0.24; both P0.02).Increased epicardial fat per se does not necessarily translate into presence or prediction of disease. In contrast, increased deposition of visceral abdominal and extra-pericardial mediastinal fat are both associated with an enhanced cardiovascular disease risk profile.

Published
2011

28. Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population

Author

Handberg, A, Højlund, K, Gastaldelli, A, Flyvbjerg, A, Dekker, Jm, Petrie, J, Piatti, P, Beck Nielsen, H, Heine, Rj, Dekker, J, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Bobbioni, Eh, Barthassat, V, Makoundou, V, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, de la Perriere AB, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Östling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Casolaro, A, Astiarraga, Bd, Mingrone, G, Guidone, C, Favuzzi, A, Dirocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, B, Mari, A, Gaffney, P, Boran, G, Kok, A, Patel, S, Ciociaro, D, Mhamdi, L, Landucci, L, Hills, S, Mota, L, Pacini, G, Cavaggion, C, Hills, Sa, and Mota, L.

Subjects
Adult, CD36 Antigens, Male, Enzyme-Linked Immunosorbent Assay, Middle Aged, Atherosclerosis, Body Mass Index, Cohort Studies, Europe, Fatty Liver, Cross-Sectional Studies, Predictive Value of Tests, Diabetes Mellitus, Humans, Female, Prospective Studies, Insulin Resistance, Algorithms, Biomarkers
Abstract

Insulin resistance is associated with increased CD36 expression in a number of tissues. Moreover, excess macrophage CD36 may initiate atherosclerotic lesions. The aim of this study was to determine whether plasma soluble CD36 (sCD36) was associated with insulin resistance, fatty liver and carotid atherosclerosis in nondiabetic subjects.In 1296 healthy subjects without diabetes or hypertension recruited from 19 centres in 14 European countries (RISC study), we determined the levels of sCD36, adiponectin, lipids and liver enzymes, insulin sensitivity (M/I) by euglycaemic-hyperinsulinaemic clamp, carotid atherosclerosis as intima-media thickness (IMT) and two estimates of fatty liver, the fatty liver index (FLI) and liver fat percentage (LF%).IMT, FLI, LF%, presence of the metabolic syndrome, impaired glucose regulation, insulin and triglycerides increased across sCD36 quartiles (Q2-Q4), whereas adiponectin and M/I decreased (P ≤ 0.01). sCD36 was lower in women than in men (P = 0.045). Log sCD36 showed a bimodal distribution, and amongst subjects with sCD36 within the log-normal distribution (log-normal population, n = 1029), sCD36 was increased in subjects with impaired glucose regulation (P = 0.045), metabolic syndrome (P = 0.006) or increased likelihood of fatty liver (P0.001). sCD36 correlated significantly with insulin, triglycerides, M/I and FLI (P0.05) after adjustment for study centre, gender, age, glucose tolerance status, smoking habits and alcohol consumption. In the log-normal population, these relationships were stronger than in the total study population and, additionally, sCD36 was significantly associated with LF% and IMT (P0.05).In this cross-sectional study of nondiabetic subjects, sCD36 was significantly associated with indices of insulin resistance, carotid atherosclerosis and fatty liver. Prospective studies are needed to further evaluate the role of sCD36 in the inter-relationship between atherosclerosis, fatty liver and insulin resistance.

Published
2011

29. A novel surrogate index for hepatic insulin resistance

Author

Vangipurapu, J, Stančáková, A, Kuulasmaa, T, Paananen, J, Kuusisto, J, EGIR RISC Study Group, Ferrannini, E, Laakso, M, Heine, Rj, Dekker, J, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perrier, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Ostling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Geremia Brunetto, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, B, Dekker, Jm, Mari, A, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Landucci, L, Pacini, G, Cavaggion, C, Hills, Sa, and Mota

Published
2011

30. Liver enzymes are associated with hepatic insulin resistance, insulin secretion, and glucagon concentration in healthy men and women

Author

Bonnet, F, Ducluzeau, Ph, Gastaldelli, A, Laville, M, Anderwald, Ch, Konrad, T, Mari, A, Balkau, B, Heine, Rj, Dekker, J, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Böhles, H, Fuellert, S, Ber, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Östling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Stehr, P, Hojlund, K, Olsen, C, Hansen, L, Bolli, Geremia Brunetto, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Casolaro, A, Astiarraga, Bd, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Dekker, Jm, Petrie, J, Gaffney, P, Boran, G, Kok, A, Patel, S, Ciociaro, D, Flyvbjerg, A, Guillanneuf, Mt, Mhamdi, L, Landucci, L, Hills, S, Mota, L, Pacini, G, Cavaggion, C, Tura, A, Hills, Sa, and Mot

Published
2011

32. P0519 : Lipidomics reveals that low plasma unsaturated to saturated fat ratios are biomarkers of NAFLD and liver damage

Author

Gaggini, M., primary, Saponaro, C., additional, Rosso, C., additional, Buzzigoli, E., additional, Carli, F., additional, Ciociaro, D., additional, Mezzabotta, L., additional, Vanni, E., additional, Gambino, R., additional, Saba, F., additional, Carenzi, S., additional, Caviglia, G.P., additional, Abate, M.L., additional, Smedile, A., additional, Rizzetto, M., additional, Cassader, M., additional, Bugianesi, E., additional, and Gastaldelli, A., additional

Published
2015
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33. Effect of sedentary behaviour and vigorous physical activity on segment-specific carotid wall thickness and its progression in a healthy population

Author

Kozàkovà, M, Palombo, C, Morizzo, C, Nolan, Jj, Konrad, T, Balkau, B, Heine, Rj, Dekker, J, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sanchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Ostling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhausl, W, Roden, M, Dekker, Jm, Mari, A, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Mota, L, Pacini, G, Cavaggion, C, Hills, Sa, Landucci, L, and Mota, L.

Published
2010

34. Impact of family history on relations between insulin resistance, LDL cholesterol and carotid IMT in healthy adults

Author

Anderwald, C, Stadler, M, Golay, A, Krebs, M, Petrie, J, Luger, A, Heine, Rj, Dekker, J, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Bönles, H, Franke, S, Baer, F, Zuchhold, H, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm Kuopio, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Ostling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Bischof, M, Promintzer, M, Mandl, M, Hofer, A, Waldhäusl, W, Roden, M, Balkau, B, Dekker, Jm, Mari, A, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Pacini, G, Cavaggion, C, Hills, Sa, Landucci, L, and Mota, L.

Published
2010

35. The effect of menopause on carotid artery remodeling, insulin sensitivity, and plasma adiponectin in healthy women

Author

Muscelli, E., Kozakova, M., Flyvbjerg, A., Kyriakopoulou, K., Astiarraga, B. D., Glintborg, D., Konrad, T., Favuzzi, A., Petrie, J., Heine, R. J., Dekker, J., De Rooij, S., Nijpels, G., Boorsma, W., Mitrakou, A., Tournis, S., Thomakos, P., Lalic, N., Lalic, K., Jotic, A., Lukic, L., Civcic, M., Nolan, J., Yeow, T. P., Murphy, M., Delong, C., Neary, G., Colgan, M. P., Hatunic, M., Bohles, H., Fuellert, S., Baer, F., Zuchhold, H., Golay, A., Harsch Bobbioni, E., Barthassat, V., Makoundou, V., Lehmann, T. N. O., Merminod, T., Petrie, J. R., Perry, C., Neary, F., Macdougall, C., Shields, K., Malcolm, L., Laakso, M., Salmenniemi, U., Aura, A., Raisanen, R., Ruotsalainen, U., Sistonen, T., Laitinen, M., Saloranta, H., Coppack, S. W., Mcintosh, N., Ross, J., Pettersson, L., Khadobaksh, P., Laville, M., Bonnet, F., Brac De La Perriere, A., Louche-Pelissier, C., Maitrepierre, C., Peyrat, J., Beltran, S., Serusclat, A., Gabriel, R., Sanchez, E. M., Carraro, R., Friera, A., Novella, B., Nilsson, P., Persson, M., Ostling, G., Melander, O., Burri, P., Piatti, P. M., Monti, L. D., Setola, E., Galluccio, E., Minicucci, F., Colleluori, A., Walker, M., Ibrahim, I. M., Jayapaul, M., Carman, D., Ryan, C., Short, K., Mcgrady, Y., Richardson, D., Beck-Nielsen, H., Staehr, P., Hojlund, K., Vestergaard, V., Olsen, C., Hansen, L., Bolli, G. B., Porcellati, F., Fanelli, C., Lucidi, P., Calcinaro, F., Saturni, A., Ferrannini, E., Natali, A., Pinnola, S., Mingrone, G., Guidone, C., Di Rocco, P., Anderwald, C., Bischof, M., Promintzer, M., Krebs, M., Mandl, M., Hofer, A., Luger, A., Waldhausl, W., Roden, M., Balkau, B., Dekker, J. M., Mari, A., Gaffney, P., Boran, G., Kok, A., Patel, S., Gastaldelli, A., Ciociaro, D., Guillanneuf, M. T., Mhamdi, L., Pacini, G., Cavaggion, C., Hills, S. A., Landucci, L., and Mota, L.

Subjects
Blood Glucose, medicine.medical_specialty, Carotid Artery, Common, medicine.medical_treatment, Blood Pressure, Insulin resistance, Risk Factors, medicine.artery, Internal medicine, Insulin Secretion, Internal Medicine, Medicine, Humans, Insulin, Common carotid artery, cardiovascular diseases, Ultrasonography, Adiponectin, Cardiovascular Diseases, Cross-Sectional Studies, Female, Insulin Resistance, Menopause, Middle Aged, Tunica Intima, Tunica Media, business.industry, medicine.disease, Common, Endocrinology, Blood pressure, Intima-media thickness, cardiovascular system, Carotid Artery, business, Body mass index
Abstract

BACKGROUND The mechanisms by which menopause may influence the systemic subclinical atherosclerosis are unexplained. The aim of this cross-sectional study was to evaluate the associations between early menopause, established cardiovascular (c-v) risk factors, metabolic parameters (insulin secretion and sensitivity, plasma adiponectin), and carotid intima-media thickness (IMT) in healthy women. METHODS In 74 menopausal women (mean age = 51 +/- 3 years, mean duration of menopause = 2.9 +/- 1.2 years) and in 74 nonmenopausal women comparable for age and body mass index (BMI), common carotid artery (CCA) luminal diameter, and IMT in different carotid segments were measured in digitized ultrasound images. Insulin sensitivity and secretion were assessed using the euglycemic hyperinsulinemic clamp technique and oral glucose tolerance test (OGTT). Insulin secretion was reconstructed by mathematical modeling. RESULTS CCA diameter (5.55 +/- 0.46 vs. 5.21 +/- 0.51 mm, P less than 0.001), CCA IMT (608 +/- 78 vs. 576 +/- 74 mu m, P less than 0.01) and systolic blood pressure (BP) 0 17 +/- 12 vs. 113 +/- 11 mm Hg, P less than 0.05) were higher in menopausal women, whereas CCA IMT/diameter ratio and IMT in other carotid segments did not differ between the groups. By multivariate models, independent predictors of CCA diameter were menopause and body weight (cumulative R-2 = 0.37) and independent correlates of CCA IMT were luminal diameter, systolic BP and low-density lipoprotein (LDL) cholesterol (cumulative R-2 = 0.48). Fasting insulin, insulin secretion, and sensitivity and plasma adiponectin were similar in the two groups and were not related to carotid IMT. CONCLUSIONS Early menopause is associated with CCA remodeling, characterized by a proportional increase in luminal diameter and wall thickness, independent of atherosclerotic risk factors and metabolic variables.

Published
2009
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36. Fasting insulin has a stronger association with an adverse cardiometabolic risk profile than insulin resistance: The RISC study

Author

De Rooij, S.R. Dekker, J.M. Kozakova, M. Mitrakou, A. Melander, O. Gabriel, R. Guidone, C. Højlund, K. Murphy, M.S. Nijpels, G. Dekker, J. De Rooij, S. Nijpels, G. Boorsma, W. Mitrakou, A. Tournis, S. Kyriakopoulou, K. Thomakos, P. Lalic, N. Lalic, K. Jotic, A. Lukic, L. Civcic, M. Nolan, J. Yeow, T.P. Murphy, M. DeLong, C. Neary, G. Colgan, M.P. Hatunic, M. Konrad, T. Böhles, H. Fuellert, S. Baer, F. Zuchhold, H. Golay, A. Harsch Bobbioni, E. Barthassat, V. Makoundou, V. Lehmann, T.N.O. Merminod, T. Petrie, J.R. Perry, C. Neary, F. MacDougall, C. Shields, K. Malcolm, L. Laakso, M. Salmenniemi, U. Aura, A. Raisanen, R. Ruotsalainen, U. Sistonen, T. Laitinen, M. Saloranta, H. Coppack, S.W. McIntosh, N. Ross, J. Pettersson, L. Khadobaksh, P. Laville, M. Bonnet, F. Brac De La Perriere, A. Louche-Pelissier, C. Maitrepierre, C. Peyrat, J. Beltran, S. Serusclat, A. Gabriel, R. Sánchez, M.E. Carraro, R. Friera, A. Perez, S. Nilsson, P. Persson, M. Östling, G. Melander, O. Burri, P. Piatti, P.M. Monti, L.D. Setola, E. Galluccio, E. Minicucci, F. Colleluori, A. Walker, M. Ibrahim, I.M. Jayapaul, M. Carman, D. Ryan, C. Short, K. McGrady, Y. Richardson, D. Beck-Nielsen, H. Staehr, P. Hojlund, K. Vestergaard, V. Olsen, C. Hansen, L. Bolli, G.B. Porcellati, F. Fanelli, C. Lucidi, P. Calcinaro, F. Saturni, A. Ferrannini, E. Natali, A. Muscelli, E. Pinnola, S. Kozakova, M. Mingrone, G. Guidone, C. Favuzzi, A. Di Rocco, P. Anderwald, C. Bischof, M. Promintzer, M. Krebs, M. Mandl, M. Hofer, A. Luger, A. Waldhäusl, W. Roden, M. Balkau, B. Coppack, S.W. Dekker, J.M. Ferrannini, E. Mari, A. Walker, M. Gaffney, P. Nolan, J. Boran, G. Olsen, C. Hansen, L. Beck-Nielsen, H. Kok, A. Dekker, J. Patel, S. Walker, M. Gastaldelli, A. Ciociaro, D. Kozakova, M. Guillanneuf, M.T. Balkau, B. Mhamdi, L. Balkau, B. Balkau, B. Mari, A. Mhamdi, L. Landucci, L. Hills, S. Mota, L. Mari, A. Pacini, G. Cavaggion, C. Hills, S.A. Landucci, L. Mota, L.

Abstract

Objective: Fasting insulin concentrations are often used as a surrogate measure of insulin resistance. We investigated the relative contributions of fasting insulin and insulin resistance to cardiometabolic risk and preclinical atherosclerosis. Design and methods: The Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) cohort consists of 1326 European non-diabetic, overall healthy men and women aged 30-60 years. We performed standard oral glucose tolerance tests and hyperinsulinemic euglycemic clamps. As a general measure of cardiovascular risk, we assessed the prevalence of the metabolic syndrome in 1177 participants. Carotid artery intima media thickness (IMT) was measured by ultrasound to assess preclinical atherosclerosis. Results: Fasting insulin was correlated with all elements of the metabolic syndrome. Insulin sensitivity (M/I) was correlated with most elements. The odds ratio for the metabolic syndrome of those in the highest quartile of fasting insulin compared with those in the lower quartiles was 5.4 (95% confidence interval (CI) 2.8-10.3, adjusted for insulin sensitivity) in men and 5.1 (2.6-9.9) in women. The odds ratio for metabolic syndrome of those with insulin sensitivity in the lowest quartile of the cohort compared with those in the higher quartiles was 2.4 (95% CI 1.3-4.7, adjusted for fasting insulin) in men and 1.6 (0.8-3.1) in women. Carotid IMT was only statistically significantly associated with fasting insulin in both men and women. Conclusions: Fasting insulin, a simple and practical measure, may be a stronger and independent contributor to cardiometabolic risk and atherosclerosis in a healthy population than hyperinsulinemic euglycemic clamp-derived insulin sensitivity. © 2009 European Society of Endocrinology.

Published
2009

37. The effect of menopause on carotid artery remodeling, insulin sensitivity, and plasma adiponectin in healthy women

Author

Muscelli, E. Kozàkovà, M. Flyvbjerg, A. Kyriakopoulou, K. Astiarraga, B.D. Glintborg, D. Konrad, T. Favuzzi, A. Petrie, J.R. Heine, R.J. Dekker, J. De Rooij, S. Nijpels, G. Boorsma, W. Mitrakou, A. Tournis, S. Kyriakopoulou, K. Thomakos, P. Lalic, N. Lalic, K. Jotic, A. Lukic, L. Civcic, M. Nolan, J. Yeow, T.P. Murphy, M. DeLong, C. Neary, G. Colgan, M.P. Hatunic, M. Konrad, T. Böhles, H. Fuellert, S. Baer, F. Zuchhold, H. Golay, A. Harsch Bobbioni, E. Barthassat, V. Makoundou, V. Lehmann, T.N.O. Merminod, T. Perry, C. Neary, F. MacDougall, C. Shields, K. Malcolm, L. Laakso, M. Salmenniemi, U. Aura, A. Raisanen, R. Ruotsalainen, U. Sistonen, T. Laitinen, M. Saloranta, H. Coppack, S.W. McIntosh, N. Ross, J. Pettersson, L. Khadobaksh, P. Laville, M. Bonnet, F. Brac De La Perriere, A. Louche-Pelissier, C. Maitrepierre, C. Peyrat, J. Beltran, S. Serusclat, A. Gabriel, R. Sánchez, E.M. Carraro, R. Friera, A. Novella, B. Nilsson, P. Persson, M. Östling, G. Melander, O. Burri, P. Piatti, P.M. Monti, L.D. Setola, E. Galluccio, E. Minicucci, F. Colleluori, A. Walker, M. Ibrahim, I.M. Jayapaul, M. Carman, D. Ryan, C. Short, K. McGrady, Y. Richardson, D. Beck-Nielsen, H. Staehr, P. Hojlund, K. Vestergaard, V. Olsen, C. Hansen, L. Bolli, G.B. Porcellati, F. Fanelli, C. Lucidi, P. Calcinaro, F. Saturni, A. Ferrannini, E. Natali, A. Muscelli, E. Pinnola, S. Kozakova, M. Mingrone, G. Guidone, C. Favuzzi, A. Di Rocco, P. Anderwald, C. Bischof, M. Promintzer, M. Krebs, M. Mandl, M. Hofer, A. Luger, A. Waldhäusl, W. Roden, M. Balkau, B. Coppack, S.W. Dekker, J.M. Ferrannini, E. Mari, A. Walker, M. Gaffney, P. Nolan, J. Boran, G. Olsen, C. Hansen, L. Beck-Nielsen, H. Kok, A. Dekker, J. Patel, S. Walker, M. Gastaldelli, A. Ciociaro, D. Kozakova, M. Guillanneuf, M.T. Balkau, B. Mhamdi, L. Mari, A. Pacini, G. Cavaggion, C. Hills, S.A. Landucci, L. Mota, L.

Subjects
cardiovascular system, cardiovascular diseases
Abstract

Background: The mechanisms by which menopause may influence the systemic subclinical atherosclerosis are unexplained. The aim of this cross-sectional study was to evaluate the associations between early menopause, established cardiovascular (c-v) risk factors, metabolic parameters (insulin secretion and sensitivity, plasma adiponectin), and carotid intima-media thickness (IMT) in healthy women. Methods: In 74 menopausal women (mean age = 51 ± 3 years, mean duration of menopause = 2.9 ± 1.2 years) and in 74 nonmenopausal women comparable for age and body mass index (BMI), common carotid artery (CCA) luminal diameter, and IMT in different carotid segments were measured in digitized ultrasound images. Insulin sensitivity and secretion were assessed using the euglycemic hyperinsulinemic clamp technique and oral glucose tolerance test (OGTT). Insulin secretion was reconstructed by mathematical modeling. Results: CCA diameter (5.55 ± 0.46 vs. 5.21± 0.51 mm, P < 0.001), CCA IMT (608 ± 78 vs. 576 ± 74 νm, P < 0.01) and systolic blood pressure (BP) (117 ± 12 vs. 113 ± 11 mm Hg, P < 0.05) were higher in menopausal women, whereas CCA IMT/diameter ratio and IMT in other carotid segments did not differ between the groups. By multivariate models, independent predictors of CCA diameter were menopause and body weight (cumulative R2= 0.37) and independent correlates of CCA IMT were luminal diameter, systolic BP and low-density lipoprotein (LDL) cholesterol (cumulative R2= 0.48). Fasting insulin, insulin secretion, and sensitivity and plasma adiponectin were similar in the two groups and were not related to carotid IMT. Conclusions: Early menopause is associated with CCA remodeling, characterized by a proportional increase in luminal diameter and wall thickness, independent of atherosclerotic risk factors and metabolic variables. © 2009 American Journal of Hypertension, Ltd.

Published
2009

38. The effect of menopause on carotid artery remodeling, insulin sensitivity, and plasma adiponectin in healthy women

Author

Muscelli, E, Kozàkovà, M, Flyvbjerg, A, Kyriakopoulou, K, Astiarraga, Bd, Glintborg, D, Konrad, T, Favuzzi, A, Petrie, J, Heine, Rj, Dekker, J, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Ostling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Pinnola, S, Kozakova, M, Mingrone, G, Guidone, C, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, B, Dekker, Jm, Mari, A, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Pacini, G, Cavaggion, C, Hills, Sa, Landucci, L, and Mota, L.

Published
2009

40. Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population

Author

Gastaldelli, A, Kozakova, M, Højlund, K, Flyvbjerg, A, Favuzzi, A, Mitrakou, A, Balkau, B, Heine, Rj, Dekker, J, Nijpels, G, Boorsma, W, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Bohles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Ostling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Mingrone, G, Guidone, C, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Dekker, Jm, Mari, A, Gaffney, P, Boran, G, Kok, A, Patel, S, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Pacini, G, Cavaggion, C, Hills, Sa, Landucci, L, and Mota, L.

Published
2009

43. Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects

Author

Bonnet, F, Patel, S, Laville, M, Balkau, B, Favuzzi, A, Monti, Ld, Lalic, N, Walker, M, Heine, Rj, Dekker, J, DE ROOIJ, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, HARSCH BOBBIONI, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Dundee, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Rennes, F, BRAC DE LA PERRIERE, A, LOUCHE PELISSIER, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Ostling, G, Melander, O, Burri, P, Piatti, Pm, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, BECK NIELSEN, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Geremia Brunetto, Porcellati, F, Fanelli, Carmine Giuseppe, Lucidi, P, Calcinaro, Filippo, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Mingrone, G, Guidone, C, DI ROCCO, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Dekker, Jm, Mari, A, Gaffney, P, Boran, G, Kok, A, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Landucci, L, Hills, S, Mota, L, Pacini, G, Cavaggion, C, and Hills, Sa

Published
2008

45. Insulin sensitivity in cardiological syndrome X

Author

Galvan AQ, Natali A, Muscelli E, Ciociaro D, Pecori N, Ferrannini E., CAMICI , PAOLO, Galvan, Aq, Natali, A, Muscelli, E, Ciociaro, D, Pecori, N, Camici, Paolo, and Ferrannini, E.

Abstract

Objectives. To test whether cardiological syndrome X is an insulin-resistant state. Setting, design and subjects. The coronary care unit of a referral centre for angina pectoris in Pisa, Italy. A case-control study, involving 10 patients with unequivocal (angiographycally proven) cardiological syndrome X, but normal glucose tolerance, blood pressure and lipid levels, and 13 matched healthy subjects. Main outcome measures. Insulin sensitivity and pattern of substrate oxidation (assessed by the euglycaemic insulin clamp technique in combination with indirect calorimetry). Results. Fasting plasma glucose and insulin levels were 5.05 +/- 0.11 versus 4.88 +/- 0.11 mmol l(-1) and 68 +/- 10 versus 56 +/- 6 pmol l(-1), respectively (controls versus patients, ns). During the insulin clamp, was nearly identical in (25.9 +/- 1.8 and 27.2 +/- 1.8 mu mol kg(-1) min(-1), respectively, P = 0.88). Non-oxidative glucose disposal accounted for similar proportions of total glucose uptake (59 versus 53%, patients versus controls, ns). Resting energy expenditure (13.7 +/- 0.6 versus 13.8 +/- 0.8 cal kg(-1) min(-1), ns) and insulin-induced thermogenesis were similar in the two groups. Fasting plasma NEFA concentrations (0.64 +/- 0.09 and 0.64 +/- 0.06 mmol l(-1), patients and controls, ns) fell in a similar time-course and to virtually identical nadirs (0.13 +/- 0.02 and 0.14 +/- 0.02 mmol l(-1)) after insulin infusion. Fasting plasma potassium was similar in patients and controls (3.99 +/- 0.10 and 4.16 +/- 0.04 mmol l(-1), ns), and insulin induced equivalent hypokalaemia (-14 versus -19%). Conclusions. None of the in vivo actions of insulin were impaired in patients with 'pure' syndrome X when compared to matched controls. Therefore, we conclude that cardiological syndrome X is not an insulin resistant state per se, and that any decrease in insulin sensitivity found in this condition is likely to be secondary.

Published
1996

50. P843 ALTERATION IN GLUCOSE METABOLISM AFTER AN ORAL GLUCOSE LOAD AND RELATIONSHIP WITH LIVER DAMAGE IN PATIENTS WITH NAFLD

Author

Vanni, E., primary, Mezzabotta, L., additional, Rosso, C., additional, Gaggini, M., additional, Gambino, R., additional, Salomone, F., additional, Buzzigoli, E., additional, Saponaro, C., additional, Saba, F., additional, Ciociaro, D., additional, Caviglia, G.P., additional, Abate, M.L., additional, Carenzi, S., additional, Smedile, A., additional, Rizzetto, M., additional, Cassader, M., additional, Gastaldelli, A., additional, and Bugianesi, E., additional

Published
2014
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