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8 results on '"Cire, Séverine"'

4. Early-to-mid idiopathic Parkinson’s disease shows a more cytotoxic but declined CD8-regulatory peripheral immune profile

Author

Capelle, Christophe, primary, Cire, Séverine, additional, Hansen, Maxime, additional, Pavelka, Lukas, additional, Hedin, Fanny, additional, Konstantinou, Maria, additional, Revets, Dominique, additional, Tslaf, Vera, additional, Marques, Taina, additional, Baron, Alexandre, additional, Domingues, Olivia, additional, Zeng, Ni, additional, May, Patrick, additional, Cosma, Antonio, additional, Balling, Rudi, additional, Krüger, Rejko, additional, Ollert, Markus, additional, and Hefeng, Feng, additional

Published
2022
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5. Early-to-mid idiopathic Parkinson’s disease shows a more cytotoxic but declined CD8-regulatory peripheral immune profile

Author

Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) [research center], Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) [research center], Luxembourg Institute of Health - LIH [research center], Fonds National de la Recherche - FnR [sponsor], Luxembourg Personalized Medicine Consortium (PMC) [sponsor], Capelle, Christophe, Cire, Séverine, Hansen, Maxime, Pavelka, Lukas, Hedin, Fanny, Konstantinou, Maria, Revets, Dominique, Tslaf, Vera, Marques, Taina, Baron, Alexandre, Domingues, Olivia, Zeng, Ni, May, Patrick, Cosma, Antonio, Balling, Rudi, Krüger, Rejko, Ollert, Markus, He, Feng, Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) [research center], Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) [research center], Luxembourg Institute of Health - LIH [research center], Fonds National de la Recherche - FnR [sponsor], Luxembourg Personalized Medicine Consortium (PMC) [sponsor], Capelle, Christophe, Cire, Séverine, Hansen, Maxime, Pavelka, Lukas, Hedin, Fanny, Konstantinou, Maria, Revets, Dominique, Tslaf, Vera, Marques, Taina, Baron, Alexandre, Domingues, Olivia, Zeng, Ni, May, Patrick, Cosma, Antonio, Balling, Rudi, Krüger, Rejko, Ollert, Markus, and He, Feng

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disease. Brain neuroinflammation plays a role in PD pathogenesis. However, the involvement of the peripheral immune system has not been systematically investigated. Here we analyzed >700 combinatorial immunological features in fresh blood of 28 early-to-mid-stage PD patients and 24 matched controls. We found an enhanced cytotoxic immune profile in idiopathic PD patients (iPD), with a higher frequency of terminally-differentiated effector CD8 T (TEMRA), late-differentiated CD8+ natural killer T cells and neutrophils. This immune profile was intensified by elevated serum granzyme A, reduced percentages of CD8+FOXP3+ regulatory T cells and group 2 innate lymphoid cells with immunosuppressive or tolerance-inducing functions. The frequency of CD8 TEMRA was negatively correlated with disease duration, suggesting a contribution to PD pathogenesis. Our work provides a comprehensive map on disturbed peripheral adaptive and innate immune cells in early-to-mid iPD, proposing easily-accessible candidates for early diagnosis and treatments.

Published
2022

7. Systems and Longitudinal Analysis Reveals Early-Stage and Highly Coordinated Immune Responses in Mild COVID-19 Patients

Author

Capelle, Christophe, primary, Cire, Séverine, additional, Domingues, Olivia, additional, Ernens, Isabelle, additional, Hedin, Fanny, additional, Fischer, Aurélie, additional, Snoeck, Chantal J., additional, Ammerlaan, Wim, additional, Konstantinou, Maria, additional, Grzyb, Kamil, additional, Skupin, Alexander, additional, Carty, Cara L., additional, Hilger, Christiane, additional, Gilson, Georges, additional, Celebic, Aljosa, additional, del Sol, Antonio, additional, Kaplan, Ian M., additional, Betsou, Fay, additional, Abdelrahman, Tamir, additional, Cosma, Antonio, additional, Vaillant, Michel, additional, Fagherazzi, Guy, additional, Ollert, Markus, additional, and He, Feng Q., additional

Published
2021
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