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40 results on '"Citton, Valentina"'

9. Pachymeningeal involvement in POEMS syndrome: MRI and histopathological study

Author

Briani, Chiara, Fedrigo, Marny, Manara, Renzo, Castellani, Chiara, Zambello, Renato, Citton, Valentina, Campagnolo, Marta, Torre, Chiara Dalla, Lucchetta, Marta, Orvieto, Enrico, Rotilio, Antonino, Marangoni, Sabrina, Magi, Stefania, Pareyson, Davide, Florio, Igor, Pegoraro, Elena, Thiene, Gaetano, Battistin, Leontino, Adami, Fausto, and Angelini, Annalisa

Published
2012
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11. Brain involvement in Alström syndrome

Author

Citton Valentina, Favaro Angela, Bettini Vera, Gabrieli Joseph, Milan Gabriella, Greggio Nella Augusta, Marshall Jan D, Naggert Jürgen K, Manara Renzo, and Maffei Pietro

Subjects
Alström syndrome, MRI, DTI, VBM, Medicine
Abstract

Abstract Background Alström Syndrome (AS) is a rare ciliopathy characterized by cone–rod retinal dystrophy, sensorineural hearing loss, obesity, type 2 diabetes mellitus and cardiomyopathy. Most patients do not present with neurological issues and demonstrate normal intelligence, although delayed psychomotor development and psychiatric disorders have been reported. To date, brain Magnetic Resonance Imaging (MRI) abnormalities in AS have not been explored. Methods We investigated structural brain changes in 12 genetically proven AS patients (mean-age 22 years; range: 6–45, 6 females) and 19 matched healthy and positive controls (mean-age 23 years; range: 6–43; 12 females) using conventional MRI, Voxel-Based Morphometry (VBM) and Diffusion Tensor Imaging (DTI). Results 6/12 AS patients presented with brain abnormalities such as ventricular enlargement (4/12), periventricular white matter abnormalities (3/12) and lacune-like lesions (1/12); all patients older than 30 years had vascular-like lesions. VBM detected grey and white matter volume reduction in AS patients, especially in the posterior regions. DTI revealed significant fractional anisotropy decrease and radial diffusivity increase in the supratentorial white matter, also diffusely involving those regions that appeared normal on conventional imaging. On the contrary, axial and mean diffusivity did not differ from controls except in the fornix. Conclusions Brain involvement in Alström syndrome is not uncommon. Early vascular-like lesions, gray and white matter atrophy, mostly involving the posterior regions, and diffuse supratentorial white matter derangement suggest a role of cilia in endothelial cell and oligodendrocyte function.

Published
2013
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12. Sniffin' Sticks and olfactory system imaging in patients with Kallmann syndrome

Author

Ottaviano, Giancarlo, Salvalaggio, Alessandro, Citton, Valentina, Scarpa, Bruno, Favaro, Angela, Sinisi, Antonio Agostino, Liuzzi, Raffaele, Bonanni, Guglielmo, Di Salle, Francesco, Manara, Renzo, Staffieri, Alberto, Martini, Alessandro, CANTONE, ELENA, D'ERRICO, ARIANNA, ELEFANTE, ANDREA, BRUNETTI, ARTURO, Ottaviano, Giancarlo, Cantone, Elena, D'Errico, Arianna, Salvalaggio, Alessandro, Citton, Valentina, Scarpa, Bruno, Favaro, Angela, Sinisi, Antonio Agostino, Liuzzi, Raffaele, Bonanni, Guglielmo, Di Salle, Francesco, Elefante, Andrea, Manara, Renzo, Staffieri, Alberto, Martini, Alessandro, and Brunetti, Arturo

Subjects
Adult, Male, Adolescent, Olfactory bulb volume, Odor threshold, Cortical thickness, Olfaction Disorders, Young Adult, Olfactory sulcus depth, Humans, Immunology and Allergy, Kallmann syndrome, MRI, N-butanol, Odor discrimination, Odor identification, Sniffin' Sticks, Child, Kallmann Syndrome, Magnetic Resonance Imaging, Middle Aged, Olfactory Bulb, Smell, Otorhinolaryngology2734 Pathology and Forensic Medicine, cortical thickne, Sniffin’ Stick
Abstract

The relationship between olfactory function, rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin' Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical thickness close to the OS, and olfactory phenotype.Olfaction was assessed administering Sniffin' Sticks®, in 38 KS patients and 17 controls (by means of Screening 12 test®). All subjects underwent magnetic resonance imaging (MRI) to study OB volume, sulcus depth, and cortical thickness.Compared to controls, KS patients showed smaller OB volume (p0.0001), reduced sulcus depth (p0.0001), and thicker cortex in the region close to the OS (p0.0001). Anosmic KS patients had smaller OB than controls and hyposmic KS patients; there was no difference between hyposmic KS patients and controls. OB volume correlated with Sniffin' Sticks score (r = 0.64; p0.001), OS depth (p0.0001) and, inversely, with cortical thickness changes (p0.0001). Sniffin' Sticks showed an inverse correlation with cortical thickness (r = -0.5; p0.0001) and a trend toward a statistically significant correlation with OS depth.The present study provides further evidence of the strict relationship between olfaction and OB volume. The strong correlation between OB volume and the overlying cortical changes highlights the key role of rhinencephalon in forebrain embryogenesis.

Published
2015

13. Radiotherapy in acromegaly: Long-term brain parenchymal and vascular magnetic resonance changes

Author

Milanese, Laura, primary, Martini, Chiara, additional, Scaroni, Carla, additional, Dassie, Francesca, additional, Ceccato, Filippo, additional, Della Puppa, Alessandro, additional, Denaro, Luca, additional, Bommarito, Giulia, additional, Citton, Valentina, additional, Ermani, Mario, additional, Maffei, Pietro, additional, and Manara, Renzo, additional

Published
2018
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14. SNIFFIN’ STICKS AND OLFACTORY SYSTEM IMAGING IN KALLMANN SYNDROME PATIENTS

Author

giancarlo ottaviano, Cantone, Elena, D’errico, Arianna, Salvalaggio, Alessandro, Citton, Valentina, BRUNO SCARPA, Angela Favaro, Sinisi, Antonio Agostino, Liuzzi, Raffaele, Guglielmo Bonanni, Di Salle, Francesco, Elefante, Andrea, Manara, Renzo, Staffieri, Alberto, Alessandro Martini, and Brunetti, Arturo

Published
2015

15. Pituitary morphovolumetric changes in Alström syndrome

Author

Citton, Valentina, primary, Maffei, Pietro, additional, Marshall, Jan D., additional, Baglione, Alessandro, additional, Collin, Gayle B., additional, Milan, Gabriella, additional, Vettor, Roberto, additional, Naggert, Jürgen K., additional, and Manara, Renzo, additional

Published
2016
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16. Basilar artery remodeling in Fabry disease

Author

Burlina, Alessandro P., primary, Germain, Dominique P., additional, Righetto, Silvia, additional, Citton, Valentina, additional, Guarise, Alessandro, additional, Tonioli, Ermanno, additional, Colas, Frédéric, additional, Carlier, Robert, additional, and Manara, Renzo, additional

Published
2016
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20. Sniffin’ Sticks and olfactory system imaging in patients with Kallmann syndrome

Author

Ottaviano, Giancarlo, primary, Cantone, Elena, additional, D'Errico, Arianna, additional, Salvalaggio, Alessandro, additional, Citton, Valentina, additional, Scarpa, Bruno, additional, Favaro, Angela, additional, Sinisi, Antonio Agostino, additional, Liuzzi, Raffaele, additional, Bonanni, Guglielmo, additional, Di Salle, Francesco, additional, Elefante, Andrea, additional, Manara, Renzo, additional, Staffieri, Alberto, additional, Martini, Alessandro, additional, and Brunetti, Arturo, additional

Published
2015
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22. Intracranial internal carotid artery changes in acromegaly: a quantitative magnetic resonance angiography study

Author

Manara, Renzo, primary, Gabrieli, Joseph, additional, Citton, Valentina, additional, Ceccato, Filippo, additional, Rizzati, Silvia, additional, Bommarito, Giulia, additional, Briani, Chiara, additional, Della Puppa, Alessandro, additional, Dassie, Francesca, additional, Milanese, Laura, additional, Di Salle, Francesco, additional, Ermani, Mario, additional, Scaroni, Carla, additional, Martini, Chiara, additional, and Maffei, Pietro, additional

Published
2013
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26. Herniation of cerebellar tonsils in acromegaly: prevalence, pathogenesis and clinical impact

Author

Manara, Renzo, primary, Bommarito, Giulia, additional, Rizzati, Silvia, additional, Briani, Chiara, additional, Puppa, Alessandro Della, additional, Citton, Valentina, additional, Zanchetta, Eva, additional, Zerbo, Fabio, additional, Ermani, Mario, additional, Martini, Chiara, additional, Mantero, Franco, additional, Sicolo, Nicola, additional, Maffei, Pietro, additional, and Scaroni, Carla, additional

Published
2012
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30. Endothelial Dysfunction in Carotid Elongation

Author

Baracchini, Claudio, primary, Farina, Filippo, additional, Tonello, Simone, additional, Citton, Valentina, additional, Meneghetti, Giorgio, additional, Ballotta, Enzo, additional, and Manara, Renzo, additional

Published
2011
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32. Pachymeningeal involvement in POEMS syndrome: MRI and histopathological study

Author

Briani, Chiara, primary, Fedrigo, Marny, additional, Manara, Renzo, additional, Castellani, Chiara, additional, Zambello, Renato, additional, Citton, Valentina, additional, Campagnolo, Marta, additional, Torre, Chiara Dalla, additional, Lucchetta, Marta, additional, Orvieto, Enrico, additional, Rotilio, Antonino, additional, Marangoni, Sabrina, additional, Magi, Stefania, additional, Pareyson, Davide, additional, Florio, Igor, additional, Pegoraro, Elena, additional, Thiene, Gaetano, additional, Battistin, Leontino, additional, Adami, Fausto, additional, and Angelini, Annalisa, additional

Published
2011
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33. Gliomatosis Cerebri

Author

Manara, Renzo, primary, Marasco, Rita, additional, Citton, Valentina, additional, Calderone, Milena, additional, Pos, Sandro Dal, additional, and Briani, Chiara, additional

Published
2011
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39. Early Primary Cytomegalovirus Infection in Pregnancy: Maternal Hyperimmunoglobulin Therapy Improves Outcomes Among Infants at 1 Year of Age.

Author

Visentin, Silvia, Manara, Renzo, Milanese, Laura, Da Roit, Anna, Forner, Gabriella, Salviato, Eleonora, Citton, Valentina, Magno, Fioretta Marciani, Orzan, Eva, Morando, Carla, Cusinato, Riccardo, Mengoli, Carlo, Palu, Giorgio, Ermani, Mario, Rinaldi, Roberto, Cosmi, Erich, and Gussetti, Nadia

Subjects
CYTOMEGALOVIRUS diseases, THERAPEUTIC use of immunoglobulins, HEALTH outcome assessment, VERTICAL transmission (Communicable diseases), ULTRASONIC imaging, CONFIDENCE intervals, INFANT disease treatment
Abstract

Hyperimmunoglobulin treatment for women with early (before gestational week 17) primary cytomegalovirus (CMV) infection and proven vertical transmission (ie, detection of CMV in amniotic fluid by polymerase chain reaction) improved infant outcomes at 1 year of age.Background. Primary cytomegalovirus (CMV) infection during pregnancy is the leading infectious cause of congenital neurological disabilities. Early CMV infection carries a higher risk of adverse neonatal outcome (sensorineural hearing loss or neurological deficits). Intravenous hyperimmunoglobulin (HIG) therapy seems to be promising, but its efficacy needs further investigation.Methods. Since 2002, we have enrolled consecutively all pregnant women with early (ie, before gestational week 17) CMV infection. Beginning in 2007, all women were offered treatment with HIG (200 UI per kilogram of maternal weight, in a single intravenous administration). Outcome of infants was evaluated at the age of 1 year.Results. Of the 592 women with early primary CMV infection, amniocentesis for CMV DNA detection was performed for 446. Of the 92 CMV-positive fetuses, pregnancy was terminated for 24, HIG was administered to mothers of 31, and no treatment was received by mothers of 37. Fetuses of treated mothers did not differ from fetuses of nontreated mothers according to mother's age, gestational week of infection, CMV load, or detection of abnormal ultrasonography findings. At the 1-year evaluation, 4 of 31 infants with treated mothers (13%; 95% confidence interval [CI], 1%–25%) and 16 of 37 infants with nontreated mothers (43%; 95% CI, 27%–59%) presented with poor outcomes (P < .01, by the 2-tailed Fisher exact test).Conclusions. HIG treatment improved the outcome of fetuses from women who had primary CMV infection before gestational week 17. [ABSTRACT FROM AUTHOR]

Published
2012
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40. Gliomatosis cerebri: a possible clinical and neuroradiologic "stroke mimic".

Author

Manara R, Marasco R, Citton V, Calderone M, Pos SD, and Briani C

Subjects
Aged, Aged, 80 and over, Female, Humans, Magnetic Resonance Imaging methods, Male, Neoplasms, Neuroepithelial pathology, Stroke drug therapy, Thrombolytic Therapy, Neoplasms, Neuroepithelial diagnosis, Stroke diagnosis, Tomography, X-Ray Computed methods
Abstract

Introduction: Thrombolytic therapy for acute ischemic stroke is based on clinical assessment, blood tests, and computed tomography (CT) findings. The presence of early CT ischemic changes may help support therapeutic decision. Our aim is to call attention to a likely overlooked "stroke mimic," Gliomatosis Cerebri (GC)., Case Series: Clinical and neuroimaging analysis of 3 patients with documented GC, whose acute clinical onset and CT data (lenticular and ribbon sign and a ipsilateral dot sign) were suggestive of ischemic stroke., Conclusion: Noncerebrovascular conditions may present with both acute onset and false CT signs of early ischemic stroke. Although rare, GC needs to be considered among the possible "stroke mimics" to avoid inappropriate thrombolytic therapy.

Published
2011
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