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4,577 results on '"Clarke, Michael"'

10. Porphyrin-fused graphene nanoribbons

Author

Chen, Qiang, Lodi, Alessandro, Zhang, Heng, Gee, Alex, Wang, Hai I., Kong, Fanmiao, Clarke, Michael, Edmondson, Matthew, Hart, Jack, O’Shea, James N., Stawski, Wojciech, Baugh, Jonathan, Narita, Akimitsu, Saywell, Alex, Bonn, Mischa, Müllen, Klaus, Bogani, Lapo, and Anderson, Harry L.

Published
2024
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19. Index

Author

Clarke, Michael Tavel

Published
2007

25. Bibliography

Author

Clarke, Michael Tavel

Published
2007

26. Notes

Author

Clarke, Michael Tavel

Published
2007

31. Contents

Author

Clarke, Michael Tavel

Published
2007

40. Terrorism: The new wave

Author

Clarke, Michael and Soria, Valentina

Subjects
TERRORISM - Great Britain, SECURITY, NATIONAL - Great Britain, WAR ON TERRORISM, 2001-, AL-QAIDA
Abstract

illus tab bibliog

Published
2010

43. Terrorism in the United Kingdom: Confirming its modus operandi

Author

Clarke, Michael and Soria, Valentina

Subjects
TERRORISM - Great Britain, COUNTERTERRORISM - Great Britain - Lessons Learned, TERRORISM - Lessons Learned, BOMBINGS, TERRORIST, SECURITY, NATIONAL - Great Britain
Abstract

illus bibliog

Published
2009

44. Speech, Language and Communication Needs and Mental Health: The Experiences of Speech and Language Therapists and Mental Health Professionals

Author

Hancock, Annabel, Northcott, Sarah, Hobson, Hannah, and Clarke, Michael

Abstract

Background: While the relationship between speech, language and communication needs (SLCN) and mental health difficulties has been recognized, speech and language therapists (SLTs), and mental health professionals face challenges in assessing and treating children with these co-occurring needs. There exists a gap in the evidence base for best practice for professionals working with children and young people (CYP) who experience difficulties in both areas. Aims: To explore the views of SLTs and mental health clinicians about their experiences of working with CYP exhibiting co-occurring SLCN and mental health difficulties. Methods & Procedures: Semi-structured interviews were conducted with eight SLTs and six mental health professionals, including psychotherapists, clinical psychologists, play therapists and counsellors, with experience working with CYP with SLCN. Interviews were analysed using reflexive thematic analysis and themes were identified from the data. Outcomes & Results: Participants felt that SLCN and mental health difficulties frequently co-occur. Participants described how CYP with SLCN and mental health issues commonly experience difficulties across and between the domains of language and cognition, emotional well-being and challenging behaviour. Findings suggest that there are organizational limitations in the fields of SLT and mental health that have implications for the efficacy of assessment and treatment of CYP with SLCN and mental health difficulties. Traditional talking therapies were perceived to be inaccessible and ineffective for CYP with SLCN and mental health difficulties. Interventions blending behaviour and emotion programmes with language and communication interventions were considered potentially beneficial. Conclusions & Implications: Future research should explore and evaluate current services and service set-up in SLT and mental health. The findings from this study have important implications for the efficacy of treatments provided to this population suggesting that more research needs to be done into effective diagnosis and interventions for this population.

Published
2023
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45. Relationship between Lexicon and Grammar in Children and Youth Who Use Augmentative and Alternative Communication

Author

Soto, Gloria, Clarke, Michael T., and Savaldi-Harussi, Gat

Abstract

The present study investigated the relationship between lexicon and grammar in individuals who use graphic symbol-based aided augmentative and alternative communication (AAC). Data came from 60 transcripts of generalization sessions that were part of two previous intervention studies, aimed at improving the expressive vocabulary and grammar of 12 children and youth who used graphic symbol-based AAC. The specific aims of the current study were to (a) describe vocabulary composition across different levels of expressive vocabulary and (b) analyze the relationship between global measures of expressive vocabulary and the use of grammar in individuals who use aided AAC. A series of multiple linear mixed effect regression analyses showed a positive predictive association between overall vocabulary size and the use of closed-class words, and a positive relationship between the use of verbs and the use of closed-class words. Additionally, the use of verbs had a significant positive association with the use of inflectional morphology, while the use of nouns did not. Theoretical and practical implications of these findings are discussed.

Published
2023
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47. Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer’s model

Author

Reinitz, Felicia, Chen, Elizabeth Y, di Robilant, Benedetta Nicolis, Chuluun, Bayarsaikhan, Antony, Jane, Jones, Robert C, Gubbi, Neha, Lee, Karen, Ho, William Hai Dang, Kolluru, Sai Saroja, Qian, Dalong, Adorno, Maddalena, Piltti, Katja, Anderson, Aileen, Monje, Michelle, Heller, H Craig, Quake, Stephen R, and Clarke, Michael F

Subjects
Biochemistry and Cell Biology, Biological Sciences, Regenerative Medicine, Genetics, Stem Cell Research, Alzheimer's Disease, Neurosciences, Neurodegenerative, Acquired Cognitive Impairment, Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Aging, Brain Disorders, Aetiology, 2.1 Biological and endogenous factors, Neurological, Alzheimer Disease, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Animals, Cellular Senescence, Disease Models, Animal, Inflammation, Mice, Mice, Transgenic, Neurodegenerative Diseases, Plaque, Amyloid, Ubiquitin Thiolesterase, neural stem cells, Alzheimer's, neurodegeneration, Mouse, mouse, regenerative medicine, stem cells, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease observed with aging that represents the most common form of dementia. To date, therapies targeting end-stage disease plaques, tangles, or inflammation have limited efficacy. Therefore, we set out to identify a potential earlier targetable phenotype. Utilizing a mouse model of AD and human fetal cells harboring mutant amyloid precursor protein, we show cell intrinsic neural precursor cell (NPC) dysfunction precedes widespread inflammation and amyloid plaque pathology, making it the earliest defect in the evolution of the disease. We demonstrate that reversing impaired NPC self-renewal via genetic reduction of USP16, a histone modifier and critical physiological antagonist of the Polycomb Repressor Complex 1, can prevent downstream cognitive defects and decrease astrogliosis in vivo. Reduction of USP16 led to decreased expression of senescence gene Cdkn2a and mitigated aberrant regulation of the Bone Morphogenetic Signaling (BMP) pathway, a previously unknown function of USP16. Thus, we reveal USP16 as a novel target in an AD model that can both ameliorate the NPC defect and rescue memory and learning through its regulation of both Cdkn2a and BMP signaling.

Published
2022

48. Letters

Author

Clarke, Michael

Published
2013

50. Complications, Visual Acuity, and Refractive Error 3 Years after Secondary Intraocular Lens Implantation for Pediatric Aphakia

Author

Freedman, Sharon F., Wallace, David K., Enyedi, Laura B., Prakalapakorn, Sasapin, Jones, Sarah K., Hug, Denise, Stahl, Erin D., Dent, Rebecca J., Kong, Lingkun, Wang, Serena, Gallerson, Bryan K., Hutchinson, Amy K., Lenhart, Phoebe, Brower, Judy, Morrison, David G., Ruark, Scott T., Mets-Halgrimson, Rebecca, Yoon, Hawke, Ralay-Ranaivo, Hantamalala, Hamidullah, Aaliyah, Areaux, Raymond, Anderson, Jill S., Holleschau, Ann M., Superstein, Rosanne, Belanger, Caroline, Fallaha, Nicole, Hamel, Patrick, Thibeault, Maryse, Tamkins, Susanna M., Chang, Ta, Park, Hee-Jung S., Trumler, Anya A., Liu, Xiaonong, Astle, William F., Sanders, Emi N., Traboulsi, Elias, Ghasia, Fatema, McOwen, Diana C., Gray, Michael E., Yang, Michael B., Bowman, Corey S., Galvin, Jennifer, Therriault, Margaret, Smith, Heather, Whitaker, Michele E., Orge, Faruk, Grigorian, Adriana P., Baird, Alicia M., Strominger, Mitchell B., Chen, Vicki, Klein, Shelley, Kemmer, Jacquelyn D., Neiman, Alexandra E., Mendoza, Myra N., Frohwein, Jill J., Bremer, Don, Cassady, Cybil, Golden, Richard, Jordan, Catherine, Rogers, David, Oravec, Sara A., Yanovitch, Tammy L., Lunsford, Keven, Nye, Christina, Shea, Caroline, Stillman, SueAnn M., LaRoche, G. Robert, Van Iderstine, Stephen C., Robertson, Elisa, Cruz, Oscar A., Ghadban, Rafif, Govreau, Dawn, Larson, Scott A., Longmuir, Susannah, Shan, Xiaoyan, Clarke, Michael P., Taylor, Kate, Powell, Christine, Hammond, Benjamin P., Gearinger, Matthew D., Czubinski, Andrea, Hendricks, Dorothy H., Jin, Jing, Salvin, Jonathan H., Fisher, Alicia, Lee, Katherine A., Brooks, Daniel, Schweinler, Bonita R., Sala, Nicholas A., Sala, Allyson M., Summers, Allison I., Karr, Daniel J., Wilson, Lorri B., Rauch, Paula K., O'Hara, Mary, Gandhi, Nandini, Hashmi, Tania, Colburn, Jeffrey, Dittman, Eileen, Whitfill, Charles R., Wheeler, Amy M., McCourt, Emily A., Singh, Jasleen, Welnick, Nanastasia, Azar, Nathalie F., Baker, Joseph, Droste, Patrick J., Peters, Robert J., Hilbrands, Jan, Pineles, Stacy L., Bernardo, Marianne J., Peterson, Edward, Peterson, Charla H., Kumar, Kartik, Melese, Ephrem, Lingua, Robert, Grijalva, Jeff, Crouch, Earl R., jr., Crouch, Earl R., III, Ventura, Gaylord, Anninger, William, Benson, Shawn L., Karp, Karen A., Smith, Jordana M., Brickman-Kelleher, Jill, Ticho, Benjamin H., Khammar, Alexander J., Clausius, Deborah A., Guo, Suquin, Suh, Donny, Chamberlain, Carolyn, Schloff, Susan, Madigan, William P., Burkman, Donna, Christiansen, Stephen P., Ramsey, Jean E., McConnell, Kate H., Friedman, Ilana, Rosado, Jose, Sauberan, Donald P., Hemberger, Jody C., Davis, Patricia L., Rudaitis, Indre, Lowery, Robert S., Cupit, Shawn, Bothun, Erick D., Mohney, Brian G., Wernimont, Suzanne M., Neilsen, Rebecca A., Herlihy, Erin P., Baran, Francine, Gladstone, Amy, Smith, Justin, Mellott, Mei, Kieser, Troy, Erzurum, S. Ayse, Colon, Beth, Shah, Birva, Quebbemann, Micaela, Beck, Roy W., Austin, Darrell S., Boyle, Nicole M., Conner, Courtney L., Chandler, Danielle L., Donahue, Quayleen, Fimbel, Brooke P., Robinson, Julianne L., Hercinovic, Amra, Hoepner, James E., Kaplon, Joseph D., Henderson, Robert J., Melia, B. Michele, Ortiz, Gillaine, Woodard, Victoria C., Stutz, Kathleen M., Sutherland, Desirae R., Wu, Rui, Everett, Donald F., Diener-West, Marie, Baker, John D., Davis, Barry, Phelps, Dale L., Poff, Stephen W., Saunders, Richard A., Tychsen, Lawrence, Bradfield, Yasmin S., Foster, Nicole C., Plager, David A., Salchow, Daniel J., Birch, Eileen E., Manny, Ruth E., Silver, Jayne L., Weise, Katherine K., Verderber, Lisa C., Repka, Michael X., Dean, Trevano W., Kraker, Raymond T., Li, Zhuokai, Yen, Kimberly G., de Alba Campomanes, Alejandra G., Young, Marielle P., Rahmani, Bahram, Haider, Kathryn M., Whitehead, George F., Lambert, Scott R., Kurup, Sudhi P., Kraus, Courtney L., Cotter, Susan A., Holmes, Jonathan M., Hatt, Sarah R., and Traboulsi, Elias I.

Published
2024
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