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2. Technical Design Report for the: PANDA Micro Vertex Detector

Author

PANDA Collaboration, Erni, W., Keshelashvili, I., Krusche, B., Steinacher, M., Heng, Y., Liu, Z., Liu, H., Shen, X., Wang, Q., Xu, H., Albrecht, M., Becker, J., Eickel, K., Feldbauer, F., Fink, M., Friedel, P., Heinsius, F. H., Held, T., Koch, H., Kopf, B., Leyhe, M., Motzko, C., Pelizäus, M., Pychy, J., Roth, B., Schröder, T., Schulze, J., Steinke, M., Trifterer, T., Wiedner, U., Zhong, J., Beck, R., Becker, M., Bianco, S., Brinkmann, K. -Th., Hammann, C., Hinterberger, F., Jäkel, R., Kaiser, D., Kliemt, R., Koop, K., Schmidt, C., Schnell, R., Thoma, U., Vlasov, P., Wendel, C., Winnebeck, A., Würschig, Th., Zaunick, H. -G., Bianconi, A., Bragadireanu, M., Caprini, M., Ciubancan, M., Pantea, D., Tarta, P. -D, De Napoli, M., Giacoppo, F., Rapisarda, E., Sfienti, C., Fiutowski, T., Idzik, N., Mindur, B., Przyborowski, D., Swientek, K., Bialkowski, E., Budzanowski, A., Czech, B., Kliczewski, S., Kozela, A., Kulessa, P., Lebiedowicz, P., Malgorzata, K., Pysz, K., Schäfer, W., Siudak, R., Szczurek, A., Brandys, P., Czyzewski, T., Czyzycki, W., Domagala, M., Hawryluk, M., Filo, G., Kwiatkowski, D., Lisowski, E., Lisowski, F., Bardan, W., Gil, D., Kamys, B., Kistryn, St., Korcyl, K., Krzemieñ, W., Magiera, A., Moskal, P., Rudy, Z., Salabura, P., Smyrski, J., Wroñska, A., Al-Turany, M., Arora, R., Augustin, I., Deppe, H., Dutta, D., Flemming, H., Götzen, K., Hohler, G., Karabowicz, R., Lehmann, D., Lewandowski, B., Lühning, J., Maas, F., Orth, H., Peters, K., Saito, T., Schepers, G., Schmidt, C. J., Schmitt, L., Schwarz, C., Schwiening, J., Voss, B., Wieczorek, P., Wilms, A., Abazov, V. M., Alexeev, G. D., Arefiev, V. A., Astakhov, V. I., Barabanov, M. Yu., Batyunya, B. V., Davydov, Yu. I., Dodokhov, V. Kh., Efremov, A. A., Fedunov, A. G., Feshchenko, A. A., Galoyan, A. S., Grigoryan, S., Karmokov, A., Koshurnikov, E. K., Lobanov, V. I., Lobanov, Yu. Yu., Makarov, A. F., Malinina, L. V., Malyshev, V. L., Mustafaev, G. A., Olshevski, A. G., Pasyuk, M. A., Perevalova, E. A., Piskun, A. A., Pocheptsov, T. A., Pontecorvo, G., Rodionov, V. K., Rogov, Yu. N., Salmin, R. A., Samartsev, A. G., Sapozhnikov, M. G., Shabratova, G. S., Skachkova, A. N., Skachkov, N. B., Strokovsky, E. A., Suleimanov, M. K., Teshev, R. Sh., Tokmenin, V. V., Uzhinsky, V. V., Vodopyanov, A. S., Zaporozhets, S. A., Zhuravlev, N. I., Zorin, A. G., Branford, D., Glazier, D., Watts, D., Woods, P., Britting, A., Eyrich, W., Lehmann, A., Uhlig, F., Dobbs, S., Metreveli, Z., Seth, K., Tann, B., Tomaradze, A., Bettoni, D., Carassiti, V., Dalpiaz, P., Drago, A., Fioravanti, E., Garzia, I., Negrini, M., Savriè, M., Stancari, G., Dulach, B., Gianotti, P., Guaraldo, C., Lucherini, V., Pace, E., Bersani, A., Macri, M., Marinelli, M., Parodi, R. F., Dormenev, V., Drexler, P., Düren, M., Eisner, T., Foehl, K., Hayrapetyan, A., Koch, P., Krïoch, B., Kühn, W., Lange, S., Liang, Y., Liu, M., Merle, O., Metag, V., Moritz, M., Nanova, M., Novotny, R., Spruck, B., Stenzel, H., Strackbein, C., Thiel, M., Clarkson, T., Euan, C., Hill, G., Hoek, M., Ireland, D., Kaiser, R., Keri, T., Lehmann, I., Livingston, K., Lumsden, P., MacGregor, D., McKinnon, B., Montgomery, R., Murray, M., Protopopescu, D., Rosner, G., Seitz, B., Yang, G., Babai, M., Biegun, A. K., Glazenborg-Kluttig, A., Guliyev, E., Jothi, V. S., Kavatsyuk, M., Lemmens, P., Löhner, H., Messchendorp, J., Poelman, T., Smit, H., van der Weele, J. C., Sohlbach, H., Büscher, M., Dosdall, R., Dzhygadlo, R., Esch, S., Gillitzer, A., Goldenbaum, F., Grunwald, D., Jha, V., Kemmerling, G., Kleines, H., Lehrach, A., Maier, R., Mertens, M., Ohm, H., Pohl, D. L., Prasuhn, D., Randriamalala, T., Ritman, J., Roeder, M., Sterzenbach, G., Stockmanns, T., Wintz, P., Wüstner, P., Kisiel, J., Li, S., Li, Z., Sun, Z., Fissum, K., Hansen, K., Isaksson, L., Lundin, M., Schröder, B., Achenbach, P., Denig, A., Distler, M., Fritsch, M., Kangh, D., Karavdina, A., Lauth, W., Michel, M., Espi, M. C. Mora, Pochodzalla, J., Sanchez, S., Sanchez-Lorente, A., Weber, T., Dormenev, V. I., Fedorov, A. A., Korzhik, M. V., Missevitch, O. V., Balanutsa, V., Chernetsky, V., Demekhin, A., Dolgolenko, A., Fedorets, P., Gerasimov, A., Goryachev, V., Boukharov, A., Malyshev, O., Marishev, I., Semenov, A., Varma, R., Ketzer, B., Konorov, I., Mann, A., Neubert, S., Paul, S., Vandenbroucke, M., Zhang, Q., Khoukaz, A., Rausmann, T., Täschner, A., Wessels, J., Baldin, E., Kotov, K., Peleganchuk, S., Tikhonov, Yu., Hennino, T., Imre, M., Kunne, R., Galliard, C. Le, Normand, J. P. Le, Marchand, D., Maroni, A., Ong, S., Pouthas, J., Ramstein, B., Rosier, P., Sudol, M., Theneau, C., Tomasi-Gustafsson, E., Van de Wiele, J., Zerguerras, T., Boca, G., Braghieri, A., Costanza, S., Fontana, A., Genova, P., Lavezzi, L., Montagna, P., Rotondi, A., Buda, V., Abramov, V. V., Davidenko, A. M., Derevschikov, A. A., Goncharenko, Y. M., Grishin, V. N., Kachanov, V. A., Konstantinov, D. A., Kormilitsin, V. A., Matulenko, Y. A., Melnik, Y. M., Meschanin, A. P., Minaev, N. G., Mochalov, V. V., Morozov, D. A., Nogach, L. V., Nurushev, S. B., Ryazantsev, A. V., Semenov, P. A., Soloviev, L. F., Uzunian, A. V., Vasiliev, A. N., Yakutin, A. E., Belostotski, S., Gavrilov, G., Itzotov, A., Kisselev, A., Kravchenko, P., Manaenkov, S., Miklukho, O., Naryshkin, Y., Veretennikov, D., Vikhrov, V., Zhadanov, A., Bäck, T., Cederwall, B., Bargholtz, C., Gerén, L., Tegnér, P. E., Thørngren, P., von Würtemberg, K. M., Fava, L., Alberto, D., Amoroso, A., Bussa, M. P., Busso, L., De Mori, F., Destefanis, M., Ferrero, L., Greco, M., Kugathasan, T., Maggiora, M., Marcello, S., Sosio, S., Spataro, S., Calvo, D., Coli, S., De Remigis, P., Filippi, A., Giraudo, G., Lusso, S., Mazza, G., Mignone, M., Rivetti, A., Wheadon, R., Zotti, L., Morra, O., Iazzi, F., Lavagno, A., Quarati, P., Szymanska, K., Birsa, R., Bradamante, F., Bressan, A., Martin, A., Clement, H., Galnander, B., Calén, H., Fransson, K., Johansson, T., Kupsc, A., Marciniewski, P., Thomé, E., Wolke, M., Zlomanczuk, J., Díaz, J., Ortiz, A., Buda, P., Dmowski, K., Korzeniewski, R., Przemyslaw, D., Slowinski, B., Borsuk, S., Chlopik, A., Guzik, Z., Kopec, J., Kozlowski, T., Melnychuk, D., Plominski, M., Szewinski, J., Traczyk, K., Zwieglinski, B., Bühler, P., Gruber, A., Kienle, P., Marton, J., Widmann, E., and Zmeskal, J.

Subjects
Physics - Instrumentation and Detectors
Abstract

This document illustrates the technical layout and the expected performance of the Micro Vertex Detector (MVD) of the PANDA experiment. The MVD will detect charged particles as close as possible to the interaction zone. Design criteria and the optimisation process as well as the technical solutions chosen are discussed and the results of this process are subjected to extensive Monte Carlo physics studies. The route towards realisation of the detector is outlined., Comment: 189 pages, 225 figures, 41 tables

Published
2012

3. Technical Design Report for the PANDA Solenoid and Dipole Spectrometer Magnets

Author

The PANDA Collaboration, Erni, W., Keshelashvili, I., Krusche, B., Steinacher, M., Heng, Y., Liu, Z., Liu, H., Shen, X., Wang, O., Xu, H., Becker, J., Feldbauer, F., Heinsius, F. -H., Held, T., Koch, H., Kopf, B., Pelizaeus, M., Schroeder, T., Steinke, M., Wiedner, U., Zhong, J., Bianconi, A., Bragadireanu, M., Pantea, D., Tudorache, A., Tudorache, V., De Napoli, M., Giacoppo, F., Raciti, G., Rapisarda, E., Sfienti, C., Bialkowski, E., Budzanowski, A., Czech, B., Kistryn, M., Kliczewski, S., Kozela, A., Kulessa, P., Pysz, K., Schaefer, W., Siudak, R., Szczurek, A., zycki, W. Czy., Domagala, M., Hawryluk, M., Lisowski, E., Lisowski, F., Wojnar, L., Gil, D., Hawranek, P., Kamys, B., Kistryn, St., Korcyl, K., Krzemien, W., Magiera, A., Moskal, P., Rudy, Z., Salabura, P., Smyrski, J., Wronska, A., Al-Turany, M., Augustin, I., Deppe, H., Flemming, H., Gerl, J., Goetzen, K., Hohler, R., Lehmann, D., Lewandowski, B., Luehning, J., Maas, F., Mishra, D., Orth, H., Peters, K., Saito, T., Schepers, G., Schmidt, C. J., Schmitt, L., Schwarz, C., Voss, B., Wieczorek, P., Wilms, A., Brinkmann, K. -T., Freiesleben, H., Jaekel, R., Kliemt, R., Wuerschig, T., Zaunick, H. -G., Abazov, V. M., Alexeev, G., Arefiev, A., Astakhov, V. I., Barabanov, M. Yu., Batyunya, B. V., Davydov, Yu. I., Dodokhov, V. Kh., Efremov, A. A., Fedunov, A. G., Feshchenko, A. A., Galoyan, A. S., Grigoryan, S., Karmokov, A., Koshurnikov, E. K., Kudaev, V. Ch., Lobanov, V. I., Lobanov, Yu. Yu., Makarov, A. F., Malinina, L. V., Malyshev, V. L., Mustafaev, G. A., Olshevski, A., Pasyuk, M. A., Perevalova, E. A., Piskun, A. A., Pocheptsov, T. A., Pontecorvo, G., Rodionov, V. K., Rogov, Yu. N., Salmin, R. A., Samartsev, A. G., Sapozhnikov, M. G., Shabratova, A., Shabratova, G. S., Skachkova, A. N., Skachkov, N. B., Strokovsky, E. A., Suleimanov, M. K., Teshev, R. Sh., Tokmenin, V. V., Uzhinsky, V. V., Vodopianov, A. S., Zaporozhets, S. A., Zhuravlev, N. I., Zorin, A. G., Branford, D., Foehl, K., Glazier, D., Watts, D., Woods, P., Eyrich, W., Lehmann, A., Teufel, A., Dobbs, S., Metreveli, Z., Seth, K., Tann, B., Tomaradze, A., Bettoni, D., Carassiti, V., Cecchi, A., Dalpiaz, P., Fioravanti, E., Garzia, I., Negrini, M., Savri`e, M., Stancari, G., Dulach, B., Gianotti, P., Guaraldo, C., Lucherini, V., Pace, E., Bersani, A., Macri, M., Marinelli, M., Parodi, R. F., Brodski, I., Doering, W., Drexler, P., Dueren, M., Gagyi-Palffy, Z., Hayrapetyan, A., Kotulla, M., Kuehn, W., Lange, S., Liu, M., Metag, V., Nanova, M., Novotny, R., Salz, C., Schneider, J., Schoenmeier, P., Schubert, R., Spataro, S., Stenzel, H., Strackbein, C., Thiel, M., Thoering, U., Yang, S., Clarkson, T., Cowie, E., Downie, E., Hill, G., Hoek, M., Ireland, D., Kaiser, R., Keri, T., Lehmann, I., Livingston, K., Lumsden, S., MacGregor, D., McKinnon, B., Murray, M., Protopopescu, D., Rosner, G., Seitz, B., Yang, G., Babai, M., Biegun, A. K., Bubak, A., Guliyev, E., Jothi, V. S., Kavatsyuk, M., Loehner, H., Messchendorp, J., Smit, H., van der Weele, J. C., Garcia, F., Riska, D. -O., Buescher, M., Dosdall, R., Dzhygadlo, R., Gillitzer, A., Grunwald, D., Jha, V., Kemmerling, G., Kleines, H., Lehrach, A., Maier, R., Mertens, M., Ohm, H., Prasuhn, D., Randriamalala, T., Ritman, J., Roeder, M., Stockmanns, T., Wintz, P., Wuestner, P., Kisiel, J., Li, S., Li, Z., Sun, Z., Fissum, S., Hansen, K., Isaksson, L., Lundin, M., Schroeder, B., Achenbach, P., Espi, M. C. Mora, Pochodzalla, J., Sanchez, S., Sanchez-Lorente, A., Dormenev, V. I., Fedorov, A. A., Korzhik, M. V., Missevitch, O. V., Balanutsa, V., Chernetsky, V., Demekhin, A., Dolgolenko, A., Fedorets, P., Gerasimov, A., Goryachev, V., Boukharov, A., Malyshev, O., Marishev, I., Semenov, A., Hoeppner, C., Ketzer, B., Konorov, I., Mann, A., Neubert, S., Paul, S., Weitzel, Q., Khoukaz, A., Rausmann, T., Taeschner, A., Wessels, J., Varma, R., Baldin, E., Kotov, K., Peleganchuk, S., Tikhonov, Yu., Boucher, J., Hennino, T., Kunne, R., Ong, S., Pouthas, J., Ramstein, B., Rosier, P., Sudol, M., Van de Wiele, J., Zerguerras, T., Dmowski, K., Korzeniewski, R., Przemyslaw, D., Slowinski, B., Boca, G., Braghieri, A., Costanza, S., Fontana, A., Genova, P., Lavezzi, L., Montagna, P., Rotondi, A., Belikov, N. I., Davidenko, A. M., Derevschikov, A. A., Goncharenko, Y. M., Grishin, V. N., Kachanov, V. A., Konstantinov, D. A., Kormilitsin, V. A., Kravtsov, V. I., Matulenko, Y. A., Melnik, Y. M., Meschanin, A. P., Minaev, N. G., Mochalov, V. V., Morozov, D. A., Nogach, L. V., Nurushev, S. B., Ryazantsev, A. V., Semenov, P. A., Soloviev, L. F., Uzunian, A. V., Vasiliev, A. N., Yakutin, A. E., Baeck, T., Cederwall, B., Bargholtz, C., Geren, L., Tegner, P. E., Belostotski, S., Gavrilov, G., Itzotov, A., Kisselev, A., Kravchenko, P., Manaenkov, S., Miklukho, O., Naryshkin, Y., Veretennikov, D., Vikhrov, V., Zhadanov, A., Fava, L., Panzieri, D., Alberto, D., Amoroso, A., Botta, E., Bressani, T., Bufalino, S., Bussa, M. P., Busso, L., De Mori, F., Destefanis, M., Ferrero, L., Grasso, A., Greco, M., Kugathasan, T., Maggiora, M., Marcello, S., Serbanut, G., Sosio, S., Bertini, R., Calvo, D., Coli, S., De Remigis, P., Feliciello, A., Filippi, A., Giraudo, G., Mazza, G., Rivetti, A., Szymanska, K., Tosello, F., Wheadon, R., Morra, O., Agnello, M., Iazzi, F., Birsa, R., Bradamante, F., Bressan, A., Martin, A., Clement, H., Ekstroem, C., Calen, H., Grape, S., Hoeistad, B., Johansson, T., Kupsc, A., Marciniewski, P., Thome, E., Zlomanczuk, J., Diaz, J., Ortiz, A., Borsuk, S., Chlopik, A., Guzik, Z., Kopec, J., Kozlowski, T., Melnychuk, D., Plominski, M., Szewinski, J., Traczyk, K., Zwieglinski, B., Buehler, P., Gruber, A., Kienle, P., Marton, J., Widmann, E., and Zmeskal, J.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

This document is the Technical Design Report covering the two large spectrometer magnets of the PANDA detector set-up. It shows the conceptual design of the magnets and their anticipated performance. It precedes the tender and procurement of the magnets and, hence, is subject to possible modifications arising during this process., Comment: 10 pages, 14MB, accepted by FAIR STI in May 2009, editors: Inti Lehmann (chair), Andrea Bersani, Yuri Lobanov, Jost Luehning, Jerzy Smyrski, Technical Coordiantor: Lars Schmitt, Bernd Lewandowski (deputy), Spokespersons: Ulrich Wiedner, Paola Gianotti (deputy)

Published
2009

4. Physics Performance Report for PANDA: Strong Interaction Studies with Antiprotons

Author

PANDA Collaboration, Erni, W., Keshelashvili, I., Krusche, B., Steinacher, M., Heng, Y., Liu, Z., Liu, H., Shen, X., Wang, O., Xu, H., Becker, J., Feldbauer, F., Heinsius, F. -H., Held, T., Koch, H., Kopf, B., Pelizaeus, M., Schroeder, T., Steinke, M., Wiedner, U., Zhong, J., Bianconi, A., Bragadireanu, M., Pantea, D., Tudorache, A., Tudorache, V., De Napoli, M., Giacoppo, F., Raciti, G., Rapisarda, E., Sfienti, C., Bialkowski, E., Budzanowski, A., Czech, B., Kistryn, M., Kliczewski, S., Kozela, A., Kulessa, P., Pysz, K., Schaefer, W., Siudak, R., Szczurek, A., zycki, W. Czy., Domagala, M., Hawryluk, M., Lisowski, E., Lisowski, F., Wojnar, L., Gil, D., Hawranek, P., Kamys, B., Kistryn, St., Korcyl, K., Krzemien, W., Magiera, A., Moskal, P., Rudy, Z., Salabura, P., Smyrski, J., Wronska, A., Al-Turany, M., Augustin, I., Deppe, H., Flemming, H., Gerl, J., Goetzen, K., Hohler, R., Lehmann, D., Lewandowski, B., Luehning, J., Maas, F., Mishra, D., Orth, H., Peters, K., Saito, T., Schepers, G., Schmidt, C. J., Schmitt, L., Schwarz, C., Voss, B., Wieczorek, P., Wilms, A., Brinkmann, K. -T., Freiesleben, H., Jaekel, R., Kliemt, R., Wuerschig, T., Zaunick, H. -G., Abazov, V. M., Alexeev, G., Arefiev, A., Astakhov, V. I., Barabanov, M. Yu., Batyunya, B. V., Davydov, Yu. I., Dodokhov, V. Kh., Efremov, A. A., Fedunov, A. G., Feshchenko, A. A., Galoyan, A. S., Grigoryan, S., Karmokov, A., Koshurnikov, E. K., Kudaev, V. Ch., Lobanov, V. I., Lobanov, Yu. Yu., Makarov, A. F., Malinina, L. V., Malyshev, V. L., Mustafaev, G. A., Olshevski, A., Pasyuk, M. A., Perevalova, E. A., Piskun, A. A., Pocheptsov, T. A., Pontecorvo, G., Rodionov, V. K., Rogov, Yu. N., Salmin, R. A., Samartsev, A. G., Sapozhnikov, M. G., Shabratova, A., Shabratova, G. S., Skachkova, A. N., Skachkov, N. B., Strokovsky, E. A., Suleimanov, M. K., Teshev, R. Sh., Tokmenin, V. V., Uzhinsky, V. V., Vodopianov, A. S., Zaporozhets, S. A., Zhuravlev, N. I., Zorin, A. G., Branford, D., Foehl, K., Glazier, D., Watts, D., Woods, P., Eyrich, W., Lehmann, A., Teufel, A., Dobbs, S., Metreveli, Z., Seth, K., Tann, B., Tomaradze, A., Bettoni, D., Carassiti, V., Cecchi, A., Dalpiaz, P., Fioravanti, E., Garzia, I., Negrini, M., Savri`e, M., Stancari, G., Dulach, B., Gianotti, P., Guaraldo, C., Lucherini, V., Pace, E., Bersani, A., Macri, M., Marinelli, M., Parodi, R. F., Brodski, I., Doering, W., Drexler, P., Dueren, M., Gagyi-Palffy, Z., Hayrapetyan, A., Kotulla, M., Kuehn, W., Lange, S., Liu, M., Metag, V., Nanova, M., Novotny, R., Salz, C., Schneider, J., Schoenmeier, P., Schubert, R., Spataro, S., Stenzel, H., Strackbein, C., Thiel, M., Thoering, U., Yang, S., Clarkson, T., Cowie, E., Downie, E., Hill, G., Hoek, M., Ireland, D., Kaiser, R., Keri, T., Lehmann, I., Livingston, K., Lumsden, S., MacGregor, D., McKinnon, B., Murray, M., Protopopescu, D., Rosner, G., Seitz, B., Yang, G., Babai, M., Biegun, A. K., Bubak, A., Guliyev, E., Jothi, V. S., Kavatsyuk, M., Loehner, H., Messchendorp, J., Smit, H., van der Weele, J. C., Garcia, F., Riska, D. -O., Buescher, M., Dosdall, R., Dzhygadlo, R., Gillitzer, A., Grunwald, D., Jha, V., Kemmerling, G., Kleines, H., Lehrach, A., Maier, R., Mertens, M., Ohm, H., Prasuhn, D., Randriamalala, T., Ritman, J., Roeder, M., Stockmanns, T., Wintz, P., Wuestner, P., Kisiel, J., Li, S., Li, Z., Sun, Z., Fissum, S., Hansen, K., Isaksson, L., Lundin, M., Schroeder, B., Achenbach, P., Espi, M. C. Mora, Pochodzalla, J., Sanchez, S., Sanchez-Lorente, A., Dormenev, V. I., Fedorov, A. A., Korzhik, M. V., Missevitch, O. V., Balanutsa, V., Chernetsky, V., Demekhin, A., Dolgolenko, A., Fedorets, P., Gerasimov, A., Goryachev, V., Boukharov, A., Malyshev, O., Marishev, I., Semenov, A., Hoeppner, C., Ketzer, B., Konorov, I., Mann, A., Neubert, S., Paul, S., Weitzel, Q., Khoukaz, A., Rausmann, T., Taeschner, A., Wessels, J., Varma, R., Baldin, E., Kotov, K., Peleganchuk, S., Tikhonov, Yu., Boucher, J., Hennino, T., Kunne, R., Ong, S., Pouthas, J., Ramstein, B., Rosier, P., Sudol, M., Van de Wiele, J., Zerguerras, T., Dmowski, K., Korzeniewski, R., Przemyslaw, D., Slowinski, B., Boca, G., Braghieri, A., Costanza, S., Fontana, A., Genova, P., Lavezzi, L., Montagna, P., Rotondi, A., Belikov, N. I., Davidenko, A. M., Derevschikov, A. A., Goncharenko, Y. M., Grishin, V. N., Kachanov, V. A., Konstantinov, D. A., Kormilitsin, V. A., Kravtsov, V. I., Matulenko, Y. A., Melnik, Y. M., Meschanin, A. P., Minaev, N. G., Mochalov, V. V., Morozov, D. A., Nogach, L. V., Nurushev, S. B., Ryazantsev, A. V., Semenov, P. A., Soloviev, L. F., Uzunian, A. V., Vasiliev, A. N., Yakutin, A. E., Baeck, T., Cederwall, B., Bargholtz, C., Geren, L., Tegner, P. E., Belostotski, S., Gavrilov, G., Itzotov, A., Kisselev, A., Kravchenko, P., Manaenkov, S., Miklukho, O., Naryshkin, Y., Veretennikov, D., Vikhrov, V., Zhadanov, A., Fava, L., Panzieri, D., Alberto, D., Amoroso, A., Botta, E., Bressani, T., Bufalino, S., Bussa, M. P., Busso, L., De Mori, F., Destefanis, M., Ferrero, L., Grasso, A., Greco, M., Kugathasan, T., Maggiora, M., Marcello, S., Serbanut, G., Sosio, S., Bertini, R., Calvo, D., Coli, S., De Remigis, P., Feliciello, A., Filippi, A., Giraudo, G., Mazza, G., Rivetti, A., Szymanska, K., Tosello, F., Wheadon, R., Morra, O., Agnello, M., Iazzi, F., Birsa, R., Bradamante, F., Bressan, A., Martin, A., Clement, H., Ekstroem, C., Calen, H., Grape, S., Hoeistad, B., Johansson, T., Kupsc, A., Marciniewski, P., Thome, E., Zlomanczuk, J., Diaz, J., Ortiz, A., Borsuk, S., Chlopik, A., Guzik, Z., Kopec, J., Kozlowski, T., Melnychuk, D., Plominski, M., Szewinski, J., Traczyk, K., Zwieglinski, B., Buehler, P., Gruber, A., Kienle, P., Marton, J., Widmann, E., Zmeskal, J., Lutz, M. F. M., Pire, B., Scholten, O., and Timmermans, R.

Subjects
High Energy Physics - Experiment
Abstract

To study fundamental questions of hadron and nuclear physics in interactions of antiprotons with nucleons and nuclei, the universal PANDA detector will be built. Gluonic excitations, the physics of strange and charm quarks and nucleon structure studies will be performed with unprecedented accuracy thereby allowing high-precision tests of the strong interaction. The proposed PANDA detector is a state-of-the art internal target detector at the HESR at FAIR allowing the detection and identification of neutral and charged particles generated within the relevant angular and energy range. This report presents a summary of the physics accessible at PANDA and what performance can be expected., Comment: 216 pages

Published
2009

5. Technical Design Report for PANDA Electromagnetic Calorimeter (EMC)

Author

PANDA Collaboration, Erni, W., Keshelashvili, I., Krusche, B., Steinacher, M., Heng, Y., Liu, Z., Liu, H., Shen, X., Wang, O., Xu, H., Becker, J., Feldbauer, F., Heinsius, F. -H., Held, T., Koch, H., Kopf, B., Pelizaeus, M., Schroeder, T., Steinke, M., Wiedner, U., Zhong, J., Bianconi, A., Bragadireanu, M., Pantea, D., Tudorache, A., Tudorache, V., De Napoli, M., Giacoppo, F., Raciti, G., Rapisarda, E., Sfienti, C., Bialkowski, E., Budzanowski, A., Czech, B., Kistryn, M., Kliczewski, S., Kozela, A., Kulessa, P., Pysz, K., Schaefer, W., Siudak, R., Szczurek, A., zycki, W. Czy., Domagala, M., Hawryluk, M., Lisowski, E., Lisowski, F., Wojnar, L., Gil, D., Hawranek, P., Kamys, B., Kistryn, St., Korcyl, K., Krzemien, W., Magiera, A., Moskal, P., Rudy, Z., Salabura, P., Smyrski, J., Wronska, A., Al-Turany, M., Augustin, I., Deppe, H., Flemming, H., Gerl, J., Goetzen, K., Hohler, R., Lehmann, D., Lewandowski, B., Luehning, J., Maas, F., Mishra, D., Orth, H., Peters, K., Saito, T., Schepers, G., Schmidt, C. J., Schmitt, L., Schwarz, C., Voss, B., Wieczorek, P., Wilms, A., Brinkmann, K. -T., Freiesleben, H., Jaekel, R., Kliemt, R., Wuerschig, T., Zaunick, H. -G., Abazov, V. M., Alexeev, G., Arefiev, A., Astakhov, V. I., Barabanov, M. Yu., Batyunya, B. V., Davydov, Yu. I., Dodokhov, V. Kh., Efremov, A. A., Fedunov, A. G., Feshchenko, A. A., Galoyan, A. S., Grigoryan, S., Karmokov, A., Koshurnikov, E. K., Kudaev, V. Ch., Lobanov, V. I., Lobanov, Yu. Yu., Makarov, A. F., Malinina, L. V., Malyshev, V. L., Mustafaev, G. A., Olshevski, A., Pasyuk, M. A., Perevalova, E. A., Piskun, A. A., Pocheptsov, T. A., Pontecorvo, G., Rodionov, V. K., Rogov, Yu. N., Salmin, R. A., Samartsev, A. G., Sapozhnikov, M. G., Shabratova, A., Shabratova, G. S., Skachkova, A. N., Skachkov, N. B., Strokovsky, E. A., Suleimanov, M. K., Teshev, R. Sh., Tokmenin, V. V., Uzhinsky, V. V., Vodopianov, A. S., Zaporozhets, S. A., Zhuravlev, N. I., Zorin, A. G., Branford, D., Foehl, K., Glazier, D., Watts, D., Woods, P., Eyrich, W., Lehmann, A., Teufel, A., Dobbs, S., Metreveli, Z., Seth, K., Tann, B., Tomaradze, A., Bettoni, D., Carassiti, V., Cecchi, A., Dalpiaz, P., Fioravanti, E., Garzia, I., Negrini, M., Savri`e, M., Stancari, G., Dulach, B., Gianotti, P., Guaraldo, C., Lucherini, V., Pace, E., Bersani, A., Macri, M., Marinelli, M., Parodi, R. F., Brodski, I., Doering, W., Drexler, P., Dueren, M., Gagyi-Palffy, Z., Hayrapetyan, A., Kotulla, M., Kuehn, W., Lange, S., Liu, M., Metag, V., Nanova, M., Novotny, R., Salz, C., Schneider, J., Schoenmeier, P., Schubert, R., Spataro, S., Stenzel, H., Strackbein, C., Thiel, M., Thoering, U., Yang, S., Clarkson, T., Cowie, E., Downie, E., Hill, G., Hoek, M., Ireland, D., Kaiser, R., Keri, T., Lehmann, I., Livingston, K., Lumsden, S., MacGregor, D., McKinnon, B., Murray, M., Protopopescu, D., Rosner, G., Seitz, B., Yang, G., Babai, M., Biegun, A. K., Bubak, A., Guliyev, E., Jothi, V. S., Kavatsyuk, M., Loehner, H., Messchendorp, J., Smit, H., van der Weele, J. C., Garcia, F., Riska, D. -O., Buescher, M., Dosdall, R., Dzhygadlo, R., Gillitzer, A., Grunwald, D., Jha, V., Kemmerling, G., Kleines, H., Lehrach, A., Maier, R., Mertens, M., Ohm, H., Prasuhn, D., Randriamalala, T., Ritman, J., Roeder, M., Stockmanns, T., Wintz, P., Wuestner, P., Kisiel, J., Li, S., Li, Z., Sun, Z., Fissum, S., Hansen, K., Isaksson, L., Lundin, M., Schroeder, B., Achenbach, P., Espi, M. C. Mora, Pochodzalla, J., Sanchez, S., Sanchez-Lorente, A., Dormenev, V. I., Fedorov, A. A., Korzhik, M. V., Missevitch, O. V., Balanutsa, V., Chernetsky, V., Demekhin, A., Dolgolenko, A., Fedorets, P., Gerasimov, A., Goryachev, V., Boukharov, A., Malyshev, O., Marishev, I., Semenov, A., Hoeppner, C., Ketzer, B., Konorov, I., Mann, A., Neubert, S., Paul, S., Weitzel, Q., Khoukaz, A., Rausmann, T., Taeschner, A., Wessels, J., Varma, R., Baldin, E., Kotov, K., Peleganchuk, S., Tikhonov, Yu., Boucher, J., Hennino, T., Kunne, R., Ong, S., Pouthas, J., Ramstein, B., Rosier, P., Sudol, M., Van de Wiele, J., Zerguerras, T., Dmowski, K., Korzeniewski, R., Przemyslaw, D., Slowinski, B., Boca, G., Braghieri, A., Costanza, S., Fontana, A., Genova, P., Lavezzi, L., Montagna, P., Rotondi, A., Belikov, N. I., Davidenko, A. M., Derevschikov, A. A., Goncharenko, Y. M., Grishin, V. N., Kachanov, V. A., Konstantinov, D. A., Kormilitsin, V. A., Kravtsov, V. I., Matulenko, Y. A., Melnik, Y. M., Meschanin, A. P., Minaev, N. G., Mochalov, V. V., Morozov, D. A., Nogach, L. V., Nurushev, S. B., Ryazantsev, A. V., Semenov, P. A., Soloviev, L. F., Uzunian, A. V., Vasiliev, A. N., Yakutin, A. E., Baeck, T., Cederwall, B., Bargholtz, C., Geren, L., Tegner, P. E., Belostotski, S., Gavrilov, G., Itzotov, A., Kisselev, A., Kravchenko, P., Manaenkov, S., Miklukho, O., Naryshkin, Y., Veretennikov, D., Vikhrov, V., Zhadanov, A., Fava, L., Panzieri, D., Alberto, D., Amoroso, A., Botta, E., Bressani, T., Bufalino, S., Bussa, M. P., Busso, L., De Mori, F., Destefanis, M., Ferrero, L., Grasso, A., Greco, M., Kugathasan, T., Maggiora, M., Marcello, S., Serbanut, G., Sosio, S., Bertini, R., Calvo, D., Coli, S., De Remigis, P., Feliciello, A., Filippi, A., Giraudo, G., Mazza, G., Rivetti, A., Szymanska, K., Tosello, F., Wheadon, R., Morra, O., Agnello, M., Iazzi, F., Birsa, R., Bradamante, F., Bressan, A., Martin, A., Clement, H., Ekstroem, C., Calen, H., Grape, S., Hoeistad, B., Johansson, T., Kupsc, A., Marciniewski, P., Thome, E., Zlomanczuk, J., Diaz, J., Ortiz, A., Borsuk, S., Chlopik, A., Guzik, Z., Kopec, J., Kozlowski, T., Melnychuk, D., Plominski, M., Szewinski, J., Traczyk, K., Zwieglinski, B., Buehler, P., Gruber, A., Kienle, P., Marton, J., Widmann, E., and Zmeskal, J.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

This document presents the technical layout and the envisaged performance of the Electromagnetic Calorimeter (EMC) for the PANDA target spectrometer. The EMC has been designed to meet the physics goals of the PANDA experiment, which is being developed for the Facility for Antiproton and Ion Research (FAIR) at Darmstadt, Germany. The performance figures are based on extensive prototype tests and radiation hardness studies. The document shows that the EMC is ready for construction up to the front-end electronics interface., Comment: 199 pages, submitted to FAIR STI on July 1st 2008, Editors: Fritz-Herbert Heinsius, Bertram Kopf, Bernd Lewandowski (Deputy Technical Coordinator), Herbert L\"ohner, Rainer Novotny (Project Coordinator), Klaus Peters, Philippe Rosier, Lars Schmitt (Technical Coordinator), Alexander Vasiliev; Spokespersons: Ulrich Wiedner, Paola Gianotti (deputy)

Published
2008

17. Methylmercury Poisoning in Iraq

Author

Bakir, F., Damluji, S. F., Amin-Zaki, L., Murtadha, M., Khalidi, A., Al-Rawi, N. Y., Tikriti, S., Dhahir, H. I., Clarkson, T. W., Smith, J. C., and Doherty, R. A.

Published
1973

18. Greener Grass

Author

Clarkson, T. A.

Abstract

For many years, the only way to have a playing field was to grow it out of the ground. However, natural turf is difficult and expensive to maintain. The 1960s saw the advent of synthetic turf. The material made it easier to stage football and baseball games at indoor venues. The most prominent example was the Astrodome in Houston, which gave the product its commonly known name, AstroTurf. Later, it is found that the synthetic turf caused a rise in injuries among players due to its hard artificial surface. Nowadays, newer synthetic turfs have been improved to have more softer yarns and built-in cushioning layers. In this article, the author compares the advantages and disadvantages between the natural turf and the synthetic one. The author also provides ideas that should be considered by schools if they opt to install synthetic turf.

Published
2006

19. Association between coronary artery vitamin D receptor expression and select systemic risks factors for coronary artery atherosclerosis.

Author

Nudy, M., Xie, R., O'Sullivan, D. M., Jiang, X., Appt, S., Register, T. C., Kaplan, J. R., Clarkson, T. B., and Schnatz, P. F.

Abstract

Copyright of Climacteric is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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23. Age-specific incidence of chickenpox

Author

Finger, Reginald, Hughes, Jeffrey P., Meade, Barry J., Pelletier, Andrew R., and Palmer, Clarkson T.

Subjects
Chickenpox -- Prevention, Disease susceptibility -- Demographic aspects, Chickenpox vaccine -- Usage
Abstract

Synopsis Because licensure of a chickenpox (varicella) vaccine is likely soon, it is important to ascertain the age-specific incidence of chickenpox. Increasing vaccine coverage and a resulting decrease in transmission […]

Published
1994

28. Combined effects of space flight factors and radiation on humans

Author

Todd, P, Pecaut, M. J, Fleshner, M, and Clarkson, T. W

Subjects
Life Sciences (General)
Abstract

The probability that a dose of ionizing radiation kills a cell is about 10,000 times the probability that the cell will be transformed to malignancy. On the other hand, the number of cells killed required to significantly impact health is about 10,000 times the number that must be transformed to cause a late malignancy. If these two risks, cell killing and malignant transformation, are about equal, then the risk that occurs during a mission is more significant than the risk that occurs after a mission. The latent period for acute irradiation effects (cell killing) is about 2-4 weeks; the latent period for malignancy is 10-20 years. If these statements are approximately true, then the impact of cell killing on health in the low-gravity environment of space flight should be examined to establish an estimate of risk. The objective of this study is to synthesize data and conclusions from three areas of space biology and environmental health to arrive at rational risk assessment for radiations received by spacecraft crews: (1) the increased physiological demands of the space flight environment; (2) the effects of the space flight environment on physiological systems; and (3) the effects of radiation on physiological systems. One physiological system has been chosen: the immune response and its components, consisting of myeloid and lymphoid proliferative cell compartments. Best-case and worst-case scenarios are considered. In the worst case, a doubling of immune-function demand, accompanied by a halving of immune capacity, would reduce the endangering dose to a crew member to around 1 Gy.

Published
1999
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30. Experiments on Na Transport of Frog Skin Epithelium

Author

Clarkson, T. W., Lindemann, B., Armstrong, W. McD., Baumann, K., Caldwell, P. C., Clarkson, T. W., Dudel, J., Frankenhaeuser, B., Frömter, E., Gardos, G., Gilzburg, B. Z., Hoffman, J. F., Kepes, A., Keynes, R. D., Kleinzeller, A., Kostyuk, P. G., Kotyk, A., Lev, A. A., Lindemann, B., Mueller, P., Muth, H., Nonner, W., Oberhausen, E., Passow, H., Rothstein, A., Rudin, D. O., Stämpfli, R., Teorell, T., Ullrich, K. J., Walker, N. A., and Wilbrandt, W.

Published
1969
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31. Murine thymic lymphoma is associated with a species-specific hematopoietic progenitor cell subpopulation

Author

Irons, R. D, Colagiovanni, D. B, Stillman, W. S, and Clarkson, T. W

Subjects
Life Sciences (General)
Abstract

Many strains of laboratory mouse are uniquely susceptible to the development of T cell lymphoma/leukemia, either spontaneously or as a result of chemical or radiation exposure. In contrast, T cell leukemias or lymphomas which are relatively uncommon in human populations, are not easily induced by radiation, and are not generally associated with chemotherapy or chemical exposure. Evidence is presented to suggest that differences in the susceptibility to the development of these malignancies is related to subtle but important variations in the regulation of hematopoietic stem cell differentiation between these two species.

Published
1996
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32. Characterization of the early pulmonary inflammatory response associated with PTFE fume exposure

Author

Johnston, C. J, Finkelstein, J. N, Gelein, R, Baggs, R, Oberdorster, G, and Clarkson, T. W

Subjects
Life Sciences (General)
Abstract

Heating of polytetrafluoroethylene (PTFE) has been described to release fumes containing ultrafine particles (approximately 18 nm diam). These fumes can be highly toxic in the respiratory tract inducing extensive pulmonary edema with hemorrhagic inflammation. Fischer-344 rats were exposed to PTFE fumes generated by temperatures ranging from 450 to 460 degrees C for 15 min at an exposure concentration of 5 x 10(5) particles/cm3, equivalent to approximately 50 micrograms/m3. Responses were examined 4 hr post-treatment when these rats demonstrated 60-85% neutrophils (PMNs) in their lung lavage. Increases in abundance for messages encoding the antioxidants manganese superoxide dismutase and metallothionein (MT) increased 15- and 40-fold, respectively. For messages encoding the pro- and anti-inflammatory cytokines: inducible nitric oxide synthase, interleukin 1 alpha, 1 beta, and 6 (IL-1 alpha, IL-1 beta, and IL-6), macrophage inflammatory protein-2, and tumor necrosis factor-alpha (TNF alpha) increases of 5-, 5-, 10-, 40-, 40-, and 15-fold were present. Vascular endothelial growth factor, which may play a role in the integrity of the endothelial barrier, was decreased to 20% of controls. In situ sections were hybridized with 33P cRNA probes encoding IL-6, MT, surfactant protein C, and TNF alpha. Increased mRNA abundance for MT and IL-6 was expressed around all airways and interstitial regions with MT and IL-6 demonstrating similar spatial distribution. Large numbers of activated PMNs expressed IL-6, MT, and TNF alpha. Additionally, pulmonary macrophages and epithelial cells were actively involved. These observations support the notion that PTFE fumes containing ultrafine particles initiate a severe inflammatory response at low inhaled particle mass concentrations, which is suggestive of an oxidative injury. Furthermore, PMNs may actively regulate the inflammatory process through cytokine and antioxidant expression.

Published
1996
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33. The intersection of risk assessment and neurobehavioral toxicity

Author

Weiss, B, Elsner, J, and Clarkson, T. W

Subjects
Life Sciences (General)
Abstract

Neurobehavioral toxicology is now established as a core discipline of the environmental health sciences. Despite its recognized scientific prowess, stemming from its deep roots in psychology and neuroscience and its acknowledged successes, it faces additional demands and challenges. The latter, in fact, are a product of its achievements because success at one level leads to new and higher expectations. Now the discipline is counted upon to provide more definitive and extensive risk assessments than in the past. These new demands are the basis for the appraisals presented in the SGOMSEC 11 workshop. They extend beyond what would be offered in a primer of methodology. Instead, these appraisals are framed as issues into which what are usually construed as methodologies have been embedded.

Published
1996

34. Biological monitoring of iodine, a water disinfectant for long-term space missions

Author

Zareba, G, Cernichiari, E, Goldsmith, L. A, and Clarkson, T. W

Subjects
Life Sciences (General)
Abstract

In order to establish guidelines for exposure of astronauts to iodine, used as a water disinfectant in space, we studied the usefulness of hair, saliva, and urine for biological monitoring in humans and in the human hair/nude mouse model. The monitoring of iodine in patients that received 150 mCi of Na131I (carrier-free) showed similar patterns of elimination for blood, saliva, and urine. The mean correlation coefficient (r) between iodine elimination for blood/saliva was 0.99, for blood/urine, 0.95, and for saliva/urine, 0.97. The absolute value of iodine concentrations in urine revealed marked variability, which was corrected by adjusting for creatinine levels. The autoradiographic studies of human hair demonstrated that iodine is rapidly incorporated into external layers of the hair root and can be removed easily during washing. These data were confirmed after iodine exposure using the human hair/nude mouse model. Hair does not provide satisfactory information about exposure due to unstable incorporation of iodine. The most useful medium for biological monitoring of astronauts exposed to high doses of iodine in drinking water is urine, when adjusted for creatinine, and saliva, if quantitative evaluation of flow rate is provided.

Published
1995

35. Association of particulate air pollution and acute mortality: involvement of ultrafine particles?

Author

Oberdorster, G, Gelein, R. M, Ferin, J, Weiss, B, and Clarkson, T. W

Subjects
Environment Pollution
Abstract

Recent epidemiological studies show an association between particulate air pollution and acute mortality and morbidity down to ambient particle concentrations below 100 micrograms/m3. Whether this association also implies a causality between acute health effects and particle exposure at these low levels is unclear at this time; no mechanism is known that would explain such dramatic effects of low ambient particle concentrations. Based on results of our past and most recent inhalation studies with ultrafine particles in rats, we propose that such particles, that is, particles below approximately 50 nm in diameter, may contribute to the observed increased mortality and morbidity In the past we demonstrated that inhalation of highly insoluble particles of low intrinsic toxicity, such as TiO2, results in significantly increased pulmonary inflammatory responses when their size is in the ultrafine particle range, approximately 20 nm in diameter. However, these effects were not of an acute nature and occurred only after prolonged inhalation exposure of the aggregated ultrafine particles at concentrations in the milligrams per cubic meter range. In contrast, in the course of our most recent studies with thermodegradation products of polytetrafluoroethylene (PTFE) we found that freshly generated PTFE fumes containing singlet ultrafine particles (median diameter 26 nm) were highly toxic to rats at inhaled concentrations of 0.7-1.0 x 10(6) particles/cm3, resulting in acute hemorrhagic pulmonary inflammation and death after 10-30 min of exposure. We also found that work performance of the rats in a running wheel was severely affected by PTFE fume exposure. These results confirm reports from other laboratories of the highly toxic nature of PTFE fumes, which cannot be attributed to gas-phase components of these fumes such as HF, carbonylfluoride, or perfluoroisobutylene, or to reactive radicals. The calculated mass concentration of the inhaled ultrafine PTFE particles in our studies was less than 60 micrograms/m3, a very low value to cause mortality in healthy rats. Aging of the fumes with concomitant aggregation of the ultrafine particles significantly decreases their toxicity. Since ultrafine particles are always present in the urban atmosphere, we suggest that they play a role in causing acute lung injury in sensitive parts of the population.

Published
1995

36. Aqueous nitrite ion determination by selective reduction and gas phase nitric oxide chemiluminescence

Author

Dunham, A. J, Barkley, R. M, Sievers, R. E, and Clarkson, T. W

Subjects
Life Sciences (General)
Abstract

An improved method of flow injection analysis for aqueous nitrite ion exploits the sensitivity and selectivity of the nitric oxide (NO) chemilluminescence detector. Trace analysis of nitrite ion in a small sample (5-160 microL) is accomplished by conversion of nitrite ion to NO by aqueous iodide in acid. The resulting NO is transported to the gas phase through a semipermeable membrane and subsequently detected by monitoring the photoemission of the reaction between NO and ozone (O3). Chemiluminescence detection is selective for measurement of NO, and, since the detection occurs in the gas-phase, neither sample coloration nor turbidity interfere. The detection limit for a 100-microL sample is 0.04 ppb of nitrite ion. The precision at the 10 ppb level is 2% relative standard deviation, and 60-180 samples can be analyzed per hour. Samples of human saliva and food extracts were analyzed; the results from a standard colorimetric measurement are compared with those from the new chemiluminescence method in order to further validate the latter method. A high degree of selectivity is obtained due to the three discriminating steps in the process: (1) the nitrite ion to NO conversion conditions are virtually specific for nitrite ion, (2) only volatile products of the conversion will be swept to the gas phase (avoiding turbidity or color in spectrophotometric methods), and (3) the NO chemiluminescence detector selectively detects the emission from the NO + O3 reaction. The method is free of interferences, offers detection limits of low parts per billion of nitrite ion, and allows the analysis of up to 180 microL-sized samples per hour, with little sample preparation and no chromatographic separation. Much smaller samples can be analyzed by this method than in previously reported batch analysis methods, which typically require 5 mL or more of sample and often need chromatographic separations as well.

Published
1995
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37. Cell proliferation and differentiation in chemical leukemogenesis

Author

Irons, R. D, Stillman, W. S, and Clarkson, T. W

Subjects
Life Sciences (General)
Abstract

In tissues such as bone marrow with normally high rates of cell division, proliferation is tightly coordinated with cell differentiation. Survival, proliferation and differentiation of early hematopoietic progenitor cells depend on the growth factors, interleukin 3 (IL-3) and/or granulocyte-macrophage colony stimulating factor (GM-CSF) and their synergism with other cytokines. We provide evidence that a characteristic shared by a diverse group of compounds with demonstrated leukemogenic potential is the ability to act synergistically with GM-CSF. This results in an increase in recruitment of a resting population of hematopoietic progenitor cells normally unresponsive to the cytokine and a twofold increase in the size of the proliferating cell population normally regarded to be at risk of transformation in leukemogenesis. These findings support the possibility that transient alterations in hematopoietic progenitor cell differentiation may be an important factor in the early stages of development of leukemia secondary to chemical or drug exposure.

Published
1993

38. Impact of maternal seafood diet on fetal exposure to mercury, selenium, and lead

Author

Grandjean, P., Weihe, P., Jorgensen, P.J., Clarkson, T., Cernichiari, E., and Videro, T.

Subjects
Maternal-fetal exchange -- Physiological aspects, Pregnant women -- Food and nutrition, Seafood -- Health aspects, Fetus -- Physiological aspects, Fetal blood -- Analysis, Mercury in the body -- Health aspects, Selenium -- Health aspects, Lead in the body -- Health aspects, Environmental issues, Health
Abstract

Umbilical cord blood from 1 023 consecutive births in the Faroe Islands showed a median blood-mercury concentration of 121 nmol/l (24.2 [mu]g/l); 250 of those samples (25.1%) had blood-mercury concentrations that exceeded 200 nmol/l (40 [mu]g/l). Maternal hair mercury concentrations showed a median of 22.5 nmol/g (4.5 [mu]g/g), and 130 samples (12.7%) contained concentrations that exceeded 50 nmol/g (10 [mu]g/g). Frequent ingestion of whale meat dinners during pregnancy and, to a much lesser degree, frequent consumption of fish, and increased parity or age were associated with high mercury concentrations in cord blood and hair. Blood-mercury levels were slightly lower if the mother had occasionally ingested alcoholic beverages. Mercury in blood correlated moderately with blood selenium (median, 1.40 [mu]mol/l). Increased selenium concentrations were associated with intake of whale meat, alcohol abstention, delivery after term, and high parity. Lead in cord blood was low (median, 82 nmol/l), particularly if the mothers had frequently had fish for dinner and had abstained from smoking., ACCUMULATION of mercury in fish, shellfish, and cetaceans results in increased human exposures to this metal in populations whose diets include a high intake of marine food.[1] An area with [...]

Published
1992

39. An investigation into the causes of stratospheric ozone loss in the southern Australasian region

Author

Lehmann, P, Karoly, D. J, Newmann, P. A, Clarkson, T. S, and Matthews, W. A

Subjects
Geophysics
Abstract

Measurements of total ozone at Macquarie Island (55 deg S, 159 deg E) reveal statistically significant reductions of approximately twelve percent during July to September when comparing the mean levels for 1987-90 with those in the seventies. In order to investigate the possibility that these ozone changes may not be a result of dynamic variability of the stratosphere, a simple linear model of ozone was created from statistical analysis of tropopause height and isentropic transient eddy heat flux, which were assumed representative of the dominant dynamic influences. Comparison of measured and modeled ozone indicates that the recent downward trend in ozone at Macquarie Island is not related to stratospheric dynamic variability and therefore suggests another mechanism, possibly changes in photochemical destruction of ozone.

Published
1992

40. Long-term winter total ozone changes at Macquarie Island

Author

Lehmann, P, Karoly, D. J, Newman, P. A, Clarkson, T. S, and Matthews, W. A

Subjects
Geophysics
Abstract

Measurements of total ozone at Macquarie Island (55 deg S, 159 deg E) reveal statistically significant reductions of approximately twelve percent during July to September when comparing the mean levels for 1987-90 with those in the seventies. A back-correction of 1963-79 Macquarie Island monthly mean ozone data is described which enabled this comparison.

Published
1992

41. Synergistic action of the benzene metabolite hydroquinone on myelopoietic stimulating activity of granulocyte/macrophage colony-stimulating factor in vitro

Author

Irons, R. D, Stillman, W. S, Colagiovanni, D. B, Henry, V. A, and Clarkson, T. W

Subjects
Life Sciences (General)
Abstract

The effects of in vitro pretreatment with benzene metabolites on colony-forming response of murine bone marrow cells stimulated with recombinant granulocyte/macrophage colony-stimulating factor (rGM-CSF) were examined. Pretreatment with hydroquinone (HQ) at concentrations ranging from picomolar to micromolar for 30 min resulted in a 1.5- to 4.6-fold enhancement in colonies formed in response to rGM-CSF that was due to an increase in granulocyte/macrophage colonies. The synergism equaled or exceeded that reported for the effects of interleukin 1, interleukin 3, or interleukin 6 with GM-CSF. Optimal enhancement was obtained with 1 microM HQ and was largely independent of the concentration of rGM-CSF. Pretreatment with other authentic benzene metabolites, phenol and catechol, and the putative metabolite trans, trans-muconaldehyde did not enhance growth factor response. Coadministration of phenol and HQ did not enhance the maximal rGM-CSF response obtained with HQ alone but shifted the optimal concentration to 100 pM. Synergism between HQ and rGM-CSF was observed with nonadherent bone marrow cells and lineage-depleted bone marrow cells, suggesting an intrinsic effect on recruitment of myeloid progenitor cells not normally responsive to rGM-CSF. Alterations in differentiation in a myeloid progenitor cell population may be of relevance in the pathogenesis of acute myelogenous leukemia secondary to drug or chemical exposure.

Published
1992

42. An analysis of particle track effects on solid mammalian tissues

Author

Todd, P and Clarkson, T. W

Subjects
Aerospace Medicine
Abstract

Relative biological effectiveness (RBE) and quality factor (Q) at extreme values of linear energy transfer (LET) have been determined on the basis of experiments with single-cell systems and specific tissue responses. In typical single-cell systems, each heavy particle (Ar or Fe) passes through a single cell or no cell. In experiments on animal tissues, however, each heavy particle passes through several cells, and the LET can exceed 200 keV micrometers-1 in every cell. In most laboratory animal tissue systems, however, only a small portion of the hit cells are capable of expressing the end-point being measured, such as cell killing, mutation or carcinogenesis. The following question was therefore addressed: do RBEs and Q factors derived from single-cell experiments properly account for the damage at high LET when multiple cells are hit by HZE tracks? A review is offered in which measured radiation effects and known tissue properties are combined to estimate on the one hand, the number of cells at risk, p3n, per track, where n is the number of cells per track based on tissue and organ geometry, and p3 is the probability that a cell in the track is capable of expressing the experimental end-point. On the other hand, the tissue and single-cell responses are compared by determining the ratio RBE in tissue/RBE in corresponding single cells. Experimental data from the literature indicate that tissue RBEs at very high LET (Fe and Ar ions) are higher than corresponding single-cell RBEs, especially in tissues in which p3n is high.

Published
1992
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46. CLIMATE-CHANGE SCIENCE

Author

Wratt, D. S., Mullan, A. B., Clarkson, T. S., and Salinger, M. J.

Published
1991

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