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An operator T is said to be k-quasi class A*n operator if T*ᵏ (|Tⁿ⁺¹|²/ⁿ⁺¹− |T*|² ) Tᵏ ≥ 0, for some positive integers n and k. In this paper, we prove that the k-quasi class A*n operators have Bishop, s property (β). Then, we give a necessary and sufficient condition for T ⊗S to be a k-quasi class A*n operator, whenever T and S are both non-zero operators. Moreover, it is shown that the Riesz idempotent for a non-zero isolated point λ0 of a k-quasi class A*n operator T say Rᵢ, is self-adjoint and ran(Rᵢ) = ker(T −λ₀) = ker(T −λ₀)*. Finally, as an application in the last section, a necessary and sufficient condition is given in such a way that the weighted conditional type operators on L² (Σ), defined by Tw,u(f) := wE(uf), belong to k-quasi- A*n class. Publisher's Version

International audience; A continuous-wave 1.6 µm-emitting InAs Quantum Dash-based Optically-Pumped Vertical-External-Cavity Surface-Emitting Laser on InP is demonstrated. The laser emits in the L-band with a stable linear polarization. Up to 163 mW output power has been obtained in multi-transverse mode regime. Single-frequency regime is achieved in the 1609-1622 nm range, with an estimated linewidth of 22 kHz in a 49 mm cavity, and a maximum emitted power of 7.9 mW at 1611 nm. In such conditions, the laser exhibits a Class-A behavior, with a cut-off frequency of 800 kHz and a shot-noise floor of −158 dB/Hz for 2 mA of detected photocurrent.

Integrons are extensively targeted as a proxy for anthropogenic impact in the environment. We developed a novel high-throughput amplicon sequencing pipeline that enables characterization of thousands of integron gene cassette-associated reads, and applied it to acquire a comprehensive overview of gene cassette composition in effluents from wastewater treatment facilities across Europe. Between 38 100 and 172 995 reads per-sample were generated and functionally characterized by screening against nr, SEED, ARDB and β-lactamase databases. Over 75% of the reads were characterized as hypothetical, but thousands were associated with toxin-antitoxin systems, DNA repair, cell membrane function, detoxification and aminoglycoside and β-lactam resistance. Among the reads characterized as β-lactamases, the carbapenemase blaOXA was dominant in most of the effluents, except for Cyprus and Israel where blaGES was also abundant. Quantitative PCR assessment of blaOXA and blaGES genes in the European effluents revealed similar trends to those displayed in the integron amplicon sequencing pipeline described above, corroborating the robustness of this method and suggesting that these integron-associated genes may be excellent targets for source tracking of effluents in downstream environments. Further application of the above analyses revealed several order-of-magnitude reductions in effluent-associated β-lactamase genes in effluent-saturated soils, suggesting marginal persistence in the soil microbiome.

O manejo de água para a cultura do meloeiro é, sem dúvida, um dos aspectos que exige mais cuidados, isto porque as necessidades hídricas são bastante variáveis. Este trabalho teve por objetivo analisar o desenvolvimento vegetativo da variedade de meloeiro Cantaloupe "Coronado F1", sob manejo de irrigação simplificado, nas condições edafoclimáticas do semiárido mineiro (Janaúba-MG). O experimento foi realizado no Campus da UNIMONTES, em Janaúba-MG; o delineamento utilizado foi o de blocos casualizados, com cinco tratamentos e quatro repetições e os tratamentos foram: T1(testemunha): manejo recomendado por literatura; T2: 50% ECA (evaporação do tanque Classe-A); T3: 75% ECA; T4: 100% ECA; T5: 125% ECA. Avaliaram-se o comprimento e a largura da planta, o número de frutos/planta, o comprimento do maior ramo, a área sombreada. Para o teor de sólidos solúveis (°Brix), a classificação dos frutos na colheita, o peso do fruto, a relação de formato e a produtividade comercial, utilizaram-se 20 frutos/parcela. Os resultados indicaram que é possível utilizar como manejo da irrigação o método simplificado, baseado em frações do tanque Classe-A, em comparação com o método recomendado pela literatura para o plantio do meloeiro Cantaloupe "Coronado F1" e que as diferentes frações não influenciaram as características de pós-colheita do meloeiro. Water management for the melon crop is undoubtedly one aspect that requires more care, since the hydric needs are very variable. This study aimed to analyze the vegetative development of the cantaloupe "Coronado F1" melon under simplified irrigation management, in the soil and climatic conditions of the semi-arid region of Minas Gerais (Janaúba MG). The experiment was conducted in the campus of UNIMONTES in Janaúba-MG, arranged in randomized blocks with five treatments and four replicates. The treatments consisted of: T1 (control): management recommended by the literature, T2: 50% ECA (evaporation of the Class-A tank), T3: 75% ECA, T4: 100% ECA, T5: 125% ECA. The evaluated carachteristics included: the length and width of the plant, number of fruits/plant, length of the longest branch, the shaded area for the soluble solids content (° Brix), sorting of fruits at the time of harvest, fruit weight, shape and business productivity relationship. Twenty fruits were analyzed plot. The results indicated that it is possible to use as irrigation management, the simplified methodology based on fractions of the Class-A tank compared with the methodology recommended by the literature for the planting of Cantaloupe "Coronado F1" melon and that the different fractions did not influence the characteristics of postharvest of the crop.

Dendritic cells (DCs), a type of professional antigen-presenting cells, are responsible for initiation and maintenance of immune responses. Here we report that a substantial proportion of DCs in tumor-bearing mice and people with cancer have high amounts of triglycerides as compared with DCs from tumor-free mice and healthy individuals. In our studies, lipid accumulation in DCs was caused by increased uptake of extracellular lipids due to upregulation of scavenger receptor A. DCs with high lipid content were not able to effectively stimulate allogeneic T cells or present tumor-associated antigens. DCs with high and normal lipid levels did not differ in expression of major histocompatibility complex and co-stimulatory molecules. However, lipid-laden DCs had a reduced capacity to process antigens. Pharmacological normalization of lipid abundance in DCs with an inhibitor of acetyl-CoA carboxylase restored the functional activity of DCs and substantially enhanced the effects of cancer vaccines. These findings suggest that immune responses in cancer can be improved by manipulating the lipid levels in DCs.

Accumulating evidence indicates that atherosclerosis is a chronic inflammatory disease. The key innate immune cells that are involved in the pathogenesis of atherosclerosis are circulating monocytes and plaque macrophages. Complex interplay between immune and metabolic processes results in pathological activity of these cells. The best understood pathological process mediated by macrophages is their inability to process modified lipoproteins properly resulting in the formation of foamy cells, which are a dangerous component of atherosclerotic plaques. Key molecules involved in the recognition and processing of modified lipoproteins are scavenger receptors (SR). This is a large family of surface expressed structurally heterogeneous receptors with a broad spectrum of endogenous and exogenous ligands. The common functional feature of SR is internalisation of extracellular components and targeting them for lysosomal degradation. However, these relatively simple functions can have complex consequences, since they are linked to diverse specific signalling pathways and to other membrane transport pathways. Moreover, scavenger receptors can co-operate with other types of receptors increasing the variability of the macrophage response to multiple extracellular ligands. At least some SRs respond to modified lipoproteins by amplification of inflammation and accumulation of macrophages in the plaque, while some SRs may support tolerogenic reactions. Outcome of different SR activities will be the decision of monocytes and macrophage to guard homeostatic balance, support atherosclerosis progression and plaque instability by inflammatory reactions, or support rapid fibrotic processes in the plaque that stabilise it. Despite the accumulating knowledge about the molecular mechanisms of scavenger receptor action, their role in the progression of atherosclerosis remains controversial. The activities of scavenger receptors that can contribute to each of these processes are a subject of current review. (C) 2012 Elsevier GmbH. All rights reserved.