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1. The 'window of susceptibility' for inflammation in the immature central nervous system is characterized by a leaky blood–brain barrier and the local expression of inflammatory chemokines

Author

Lucia Schoderboeck, Milena Adzemovic, Eva-Maria Nicolussi, Claudia Crupinschi, Sonja Hochmeister, Marie-Therese Fischer, Hans Lassmann, and Monika Bradl

Subjects
Immature CNS, Inflammation, Chemokines, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Early in postnatal development, the immature central nervous system (CNS) is more susceptible to inflammation than its adult counterpart. We show here that this “window of susceptibility” is characterized by the presence of leaky vessels in the CNS, and by a global chemokine expression profile which is clearly distinct from the one observed in the adult CNS and has three important characteristics. First, it contains chemokines with known roles in the differentiation and maturation of glia and neurons. Secondly, these chemokines have been described before in inflammatory lesions of the CNS, where they are important for the recruitment of monocytes and T cells. Lastly, the chemokine profile is shaped by pathological changes like oligodendrocyte stress and attempts of myelin repair. Changes in the chemokine expression profile along with a leaky blood–brain barrier pave the ground for an accelerated development of CNS inflammation.

Published
2009
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2. The 'window of susceptibility' for inflammation in the immature central nervous system is characterized by a leaky blood–brain barrier and the local expression of inflammatory chemokines

Author

Monika Bradl, Hans Lassmann, Marie-Therese Fischer, Eva-Maria Nicolussi, Milena Z. Adzemovic, Lucia Schoderboeck, Claudia Crupinschi, and Sonja Hochmeister

Subjects
Aging, Chemokine, Encephalomyelitis, Autoimmune, Experimental, CD3 Complex, Neuroimmunomodulation, CD8 Antigens, T-Lymphocytes, Central nervous system, Inflammation, Immature CNS, Blood–brain barrier, Article, lcsh:RC321-571, Capillary Permeability, 03 medical and health sciences, Myelin, 0302 clinical medicine, medicine, Animals, Myelin Proteolipid Protein, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, 030304 developmental biology, 0303 health sciences, biology, Macrophages, Oligodendrocyte, Chemokine Expression Profile, Rats, Myelin proteolipid protein, medicine.anatomical_structure, Animals, Newborn, Spinal Cord, Neurology, Blood-Brain Barrier, Rats, Inbred Lew, biology.protein, Rats, Transgenic, medicine.symptom, Chemokines, Neuroscience, 030217 neurology & neurosurgery, Granulocytes
Abstract

Early in postnatal development, the immature central nervous system (CNS) is more susceptible to inflammation than its adult counterpart. We show here that this “window of susceptibility” is characterized by the presence of leaky vessels in the CNS, and by a global chemokine expression profile which is clearly distinct from the one observed in the adult CNS and has three important characteristics. First, it contains chemokines with known roles in the differentiation and maturation of glia and neurons. Secondly, these chemokines have been described before in inflammatory lesions of the CNS, where they are important for the recruitment of monocytes and T cells. And last, the chemokine profile is shaped by pathological changes like oligodendrocyte stress and attempts of myelin repair. Changes in the chemokine expression profile along with a leaky blood brain barrier pave the ground for an accelerated development of CNS inflammation.

Published
2009

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