1. Quantification of relative afferent pupillary defect by an automated pupillometer and its relationship with visual acuity and dimensions of macular lesions in age-related macular degeneration
- Author
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N. Kannan, RenuP Rajan, RavillaD Ravindran, ClaudioM Privitera, AmitK Deb, Kim Ramasamy, and Sonali Lomte
- Subjects
automated pupillometer ,medicine.medical_specialty ,Retinal Disorder ,Visual acuity ,genetic structures ,Visual Acuity ,Reflex, Pupillary ,Lesion ,Macular Degeneration ,Optical coherence tomography ,Retinal Diseases ,Pupil Disorders ,Ophthalmology ,Afferent Pupillary Defect ,medicine ,choroidal neovascular membrane ,Humans ,Prospective Studies ,Physical Examination ,Special Focus, Retina, Original Article ,medicine.diagnostic_test ,business.industry ,Age-related macular degeneration ,Pupil ,Macular degeneration ,RE1-994 ,medicine.disease ,eye diseases ,RAPD ,Macular Lesion ,relative afferent pupillary defect ,Cross-Sectional Studies ,Commentary ,sense organs ,medicine.symptom ,business ,Tomography, Optical Coherence - Abstract
Purpose The occurrence of relative afferent pupillary defect (RAPD) secondary to optic nerve diseases and widespread retinal disorders is well established. However, only very few reports of RAPD in macular disorders exist in the literature. In this study, we used automated pupillometer to evaluate RAPD in eyes with macular lesions. Methods It was a prospective cross-sectional study. A total of 82 patients with choroidal neovascular membrane (CNVM) - 65 unilateral and 17 bilateral macular lesions - were enrolled. RAPD was assessed with an automated pupillometer and macular lesions evaluated with optical coherence tomography (OCT). The length of the ellipsoid zone disruption was measured as the longest length of lesion on the horizontal raster scans and the area of macular lesion was measured manually, mapping the affected area of ellipsoid zone on the enface images. Results : RAPD scores showed good correlation with the intereye difference in length of maximum ellipsoid zone disruption (r-value = 0.84, P value
- Published
- 2021