81 results on '"Clauser SB"'
Search Results
2. A review of quality of care evaluation for the palliation of dyspnea.
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Mularski RA, Campbell ML, Asch SM, Reeve BB, Basch E, Maxwell TL, Hoverman JR, Cuny J, Clauser SB, Snyder C, Seow H, Wu AW, and Dy S
- Abstract
Assessment and management of dyspnea has emerged as a priority topic for quality evaluation and improvement. Evaluating dyspnea quality of care requires valid, reliable, and responsive measures of the care provided to patients across settings and diseases. As part of an Agency for Healthcare Research and Quality Symposium, we reviewed quality of care measures for dyspnea by compiling quality measures identified in systematic searches and reviews. Systematic reviews identified only three existing quality measurement sets that included quality measures for dyspnea care. The existing dyspnea quality measures reported by retrospective evaluations of care assess only four aspects: dyspnea assessment within 48 hours of hospital admission, use of objective scales to rate dyspnea severity, identification of management plans, and evidence of dyspnea reduction. To begin to improve care, clinicians need to assess and regularly document patient's experiences of dyspnea. There is no consensus on how dyspnea should be characterized for quality measurement, and although over 40 tools exist to assess dyspnea, no rating scale or instrument is ideal for palliative care. The panel recommended that dyspnea assessment should include a measure of intensity and some inquiry into the associated bother or distress experienced by the patient. A simple question into the presence or absence of dyspnea would be unlikely to help guide therapy, as complete relief of dyspnea in advanced disease would not be anticipated. Additional knowledge gaps include standards for clinical dyspnea care, assessment in the cognitively impaired, and evaluation of effectiveness of dyspnea care for patients with advanced disease. [ABSTRACT FROM AUTHOR]
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- 2010
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3. Standardizing patient-reported outcomes assessment in cancer clinical trials: a patient-reported outcomes measurement information system initiative.
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Garcia SF, Cella D, Clauser SB, Flynn KE, Lai JS, Reeve BB, Smith AW, Stone AA, and Weinfurt K
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- 2007
4. Use of cancer performance measures in population health: a macro-level perspective.
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Clauser SB
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- 2004
5. Cancer outcomes research.
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Lipscomb J, Donaldson MS, Arora NK, Brown ML, Clauser SB, Potosky AL, Reeve BB, Rowland JH, Snyder CF, and Taplin SH
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- 2004
6. Conduct of Large, Multisite, Comparative Clinical Effectiveness Research Studies: Learnings From the Patient-Centered Outcomes Research Institute's Palliative Care Learning Network.
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Paterson CL, Reefer S, Khatiwada S, Philips JG, Rodríguez B, Clauser SB, and Arora NK
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- Humans, Patient Outcome Assessment, United States, Multicenter Studies as Topic, Patient-Centered Care, Research Design, Comparative Effectiveness Research, Palliative Care
- Abstract
Competing Interests: The authors declare no conflicts of interest.
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- 2024
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7. Proceedings From a National Heart, Lung, and Blood Institute and the Centers for Disease Control and Prevention Workshop to Control Hypertension.
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Commodore-Mensah Y, Loustalot F, Himmelfarb CD, Desvigne-Nickens P, Sachdev V, Bibbins-Domingo K, Clauser SB, Cohen DJ, Egan BM, Fendrick AM, Ferdinand KC, Goodman C, Graham GN, Jaffe MG, Krumholz HM, Levy PD, Mays GP, McNellis R, Muntner P, Ogedegbe G, Milani RV, Polgreen LA, Reisman L, Sanchez EJ, Sperling LS, Wall HK, Whitten L, Wright JT, Wright JS, and Fine LJ
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- Adult, Blood Pressure, Blood Pressure Determination, Centers for Disease Control and Prevention, U.S., Humans, United States epidemiology, Hypertension diagnosis, Hypertension prevention & control, National Heart, Lung, and Blood Institute (U.S.)
- Abstract
Hypertension treatment and control prevent more cardiovascular events than management of other modifiable risk factors. Although the age-adjusted proportion of US adults with controlled blood pressure (BP) defined as <140/90 mm Hg, improved from 31.8% in 1999-2000 to 48.5% in 2007-2008, it remained stable through 2013-2014 and declined to 43.7% in 2017-2018. To address the rapid decline in hypertension control, the National Heart, Lung, and Blood Institute and the Division for Heart Disease and Stroke Prevention of the Centers for Disease Control and Prevention convened a virtual workshop with multidisciplinary national experts. Also, the group sought to identify opportunities to reverse the adverse trend and further improve hypertension control. The workshop immediately preceded the Surgeon General's Call to Action to Control Hypertension, which recognized a stagnation in progress with hypertension control. The presentations and discussions included potential reasons for the decline and challenges in hypertension control, possible "big ideas," and multisector approaches that could reverse the current trend while addressing knowledge gaps and research priorities. The broad set of "big ideas" was comprised of various activities that may improve hypertension control, including: interventions to engage patients, promotion of self-measured BP monitoring with clinical support, supporting team-based care, implementing telehealth, enhancing community-clinical linkages, advancing precision population health, developing tailored public health messaging, simplifying hypertension treatment, using process and outcomes quality metrics to foster accountability and efficiency, improving access to high-quality health care, addressing social determinants of health, supporting cardiovascular public health and research, and lowering financial barriers to hypertension control., (© The Author(s) 2021. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd.)
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- 2022
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8. Reconceptualizing Care Transitions Research From the Patient Perspective.
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Cook NL, Clauser SB, Shifreen A, and Parry C
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- Academies and Institutes, Humans, Patient Acceptance of Health Care, Social Determinants of Health, Health Services Research methods, Patient Outcome Assessment, Patient Participation, Patient Reported Outcome Measures, Transitional Care
- Abstract
Competing Interests: The authors declare no conflict of interest.
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- 2021
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9. Patient-Centered Approaches to Transitional Care Research and Implementation: Overview and Insights From Patient-Centered Outcomes Research Institute's Transitional Care Portfolio.
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Parry C, Johnston-Fleece M, Johnson MC Jr, Shifreen A, and Clauser SB
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- Academies and Institutes, Humans, Implementation Science, Comparative Effectiveness Research, Health Services Research, Patient Outcome Assessment, Patient-Centered Care, Transitional Care
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Background: This Special Issue, Future Directions in Transitional Care Research, focuses on the approaches used and lessons learned by researchers conducting care transitions studies funded by the Patient-Centered Outcomes Research Institute (PCORI). PCORI's approach to transitional care research augments prior research by encouraging researchers to focus on head-to-head comparisons of interventions, the use of patient-centered outcomes, and the engagement of stakeholders throughout the research process., Objectives: This paper introduces the themes and topics addressed by the articles that follow, which are focused on opportunities and challenges involved in conducting patient-centered clinical comparative effectiveness research in transitional care. It provides an overview of the state of the care transitions field, a description of PCORI's programmatic objectives, highlights of the patient and stakeholder engagement activities that have taken place during the course of these studies, and a brief overview of PCORI's Transitional Care Evidence to Action Network, a learning community designed to foster collaboration between investigators and their research teams and enhance the collective impact of this body of work., Conclusions: The papers in this Special Issue articulate challenges, lessons learned, and new directions for measurement, stakeholder engagement, implementation, and methodological and design approaches that reflect the complexity of transitional care comparative effectiveness research and seek to move the field toward a more holistic understanding of transitional care that integrates social needs and lifespan development into our approaches to improving care transitions., Competing Interests: The authors declare no conflict of interest., (Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.)
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- 2021
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10. Comparative Clinical Effectiveness Research Focused on Community-Based Delivery of Palliative Care: Overview of the Patient-Centered Outcomes Research Institute's Funding Initiative.
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Khan CP, Parver S, Kennedy Lesch J, DiGioia K, Gaglio B, Daugherty S, Clauser SB, and Arora NK
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- Academies and Institutes statistics & numerical data, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Palliative Care statistics & numerical data, Patient Protection and Affordable Care Act, Patient-Centered Care statistics & numerical data, Treatment Outcome, United States, Academies and Institutes organization & administration, Comparative Effectiveness Research statistics & numerical data, Outcome Assessment, Health Care statistics & numerical data, Palliative Care organization & administration, Patient Outcome Assessment, Patient-Centered Care organization & administration
- Abstract
Palliative care is a growing specialty that addresses the needs of individuals diagnosed with advanced illness and their caregivers. Although palliative care has been shown to improve a variety of patient- and caregiver-centered outcomes, access to comprehensive palliative care services for patients is often limited. There is a need to identify the most effective approaches to delivering palliative care to patients in community settings. In fiscal year 2017, based on extensive input from a diverse set of stakeholders, the Patient-Centered Outcomes Research Institute (PCORI) funded nine multisite comparative clinical effectiveness research (CER) trials focused on community-based delivery of palliative care for a total investment of $80 million. These studies, focusing on advance care planning and models of palliative care delivery, represent some of the largest most complex palliative care trials funded to date. Each study evaluates both patient and caregiver outcomes, and together, these trials include a broad range of health conditions, interventions, and settings of care. PCORI has also fostered a learning network of the funded awardees to facilitate the successful conduct of these CER studies and to support awardee efforts to develop collaborative products relevant to advancing the field of palliative care research and practice. The protocols of each of the nine trials, detailed in this issue, demonstrate the expansive reach of the investment PCORI has made in an effort to further the research agenda and provide substantive research evidence in stakeholder-identified areas of need in the field of palliative care.
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- 2019
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11. Perceptions of Patients With Breast and Colon Cancer of the Management of Cancer-Related Pain, Fatigue, and Emotional Distress in Community Oncology.
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Smith TG, Troeschel AN, Castro KM, Arora NK, Stein K, Lipscomb J, Brawley OW, McCabe RM, Clauser SB, and Ward E
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- Adaptation, Psychological, Adult, Aged, Community Health Services, Emotions, Fatigue, Female, Humans, Male, Medical Oncology, Middle Aged, Quality of Life psychology, Surveys and Questionnaires, Survivors psychology, Treatment Outcome, Young Adult, Breast Neoplasms psychology, Cancer Pain psychology, Cancer Pain therapy, Colonic Neoplasms psychology, Pain Management methods, Psychological Distress
- Abstract
Purpose: Pain, fatigue, and distress are common among patients with cancer but are often underassessed and undertreated. We examine the prevalence of pain, fatigue, and emotional distress among patients with cancer, as well as patient perceptions of the symptom care they received., Patients and Methods: Seventeen Commission on Cancer-accredited cancer centers across the United States sampled patients with local/regional breast (82%) or colon (18%) cancer. We received 2,487 completed surveys (61% response rate)., Results: Of patients, 76%, 78%, and 59% reported talking to a clinician about pain, fatigue, and distress, respectively, and 70%, 61%, and 54% reported receiving advice. Sixty-one percent of patients experienced pain, 74% fatigue, and 46% distress. Among those patients experiencing each symptom, 58% reported getting the help they wanted for pain, 40% for fatigue, and 45% for distress. Multilevel logistic regression models revealed that patients experiencing symptoms were significantly more likely to have talked about and received advice on coping with these symptoms. In addition, patients who were receiving or recently completed curative treatment reported more symptoms and better symptom care than did those who were further in time from curative treatment., Conclusion: In our sample, 30% to 50% of patients with cancer in community cancer centers did not report discussing, getting advice, or receiving desired help for pain, fatigue, or emotional distress. This finding suggests that there is room for improvement in the management of these three common cancer-related symptoms. Higher proportions of talk and advice among those experiencing symptoms imply that many discussions may be patient initiated. Lower rates of talk and advice among those who are further in time from treatment suggest the need for more assessment among longer-term survivors, many of whom continue to experience these symptoms. These findings seem to be especially important given the high prevalence of these symptoms in our sample.
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- 2019
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12. Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE): A Cluster-Randomized Pragmatic Trial of a Multifactorial Fall Injury Prevention Strategy: Design and Methods.
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Bhasin S, Gill TM, Reuben DB, Latham NK, Gurwitz JH, Dykes P, McMahon S, Storer TW, Duncan PW, Ganz DA, Basaria S, Miller ME, Travison TG, Greene EJ, Dziura J, Esserman D, Allore H, Carnie MB, Fagan M, Hanson C, Baker D, Greenspan SL, Alexander N, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace R, Casteel C, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Margolis S, Eder R, McGloin JM, Skokos E, Wiggins J, Garber L, Clauser SB, Correa-De-Araujo R, and Peduzzi P
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- Aged, Aged, 80 and over, Female, Humans, Male, Motivational Interviewing, Risk Assessment, Accidental Falls prevention & control, Wounds and Injuries prevention & control
- Abstract
Background: Fall injuries are a major cause of morbidity and mortality among older adults. We describe the design of a pragmatic trial to compare the effectiveness of an evidence-based, patient-centered multifactorial fall injury prevention strategy to an enhanced usual care., Methods: Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) is a 40-month cluster-randomized, parallel-group, superiority, pragmatic trial being conducted at 86 primary care practices in 10 health care systems across United States. The 86 practices were randomized to intervention or control group using covariate-based constrained randomization, stratified by health care system. Participants are community-living persons, ≥70 years, at increased risk for serious fall injuries. The intervention is a comanagement model in which a nurse Falls Care Manager performs multifactorial risk assessments, develops individualized care plans, which include surveillance, follow-up evaluation, and intervention strategies. Control group receives enhanced usual care, with clinicians and patients receiving evidence-based information on falls prevention. Primary outcome is serious fall injuries, operationalized as those leading to medical attention (nonvertebral fractures, joint dislocation, head injury, lacerations, and other major sequelae). Secondary outcomes include all fall injuries, all falls, and well-being (concern for falling; anxiety and depressive symptoms; physical function and disability). Target sample size was 5,322 participants to provide 90% power to detect 20% reduction in primary outcome rate relative to control., Results: Trial enrolled 5,451 subjects in 20 months. Intervention and follow-up are ongoing., Conclusions: The findings of the STRIDE study will have important clinical and policy implications for the prevention of fall injuries in older adults.
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- 2018
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13. A Patient-Centered Approach to Research on Palliative Care for Patients With Advanced Illnesses and Their Caregivers.
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Arora NK, Gayer C, DiGioia K, Mason N, Lawrence W, Clauser SB, Dunham K, Sindkar A, and Whitlock E
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- Humans, Biomedical Research methods, Caregivers, Palliative Care, Patient-Centered Care, Terminally Ill
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- 2017
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14. The National Cancer Institute Community Cancer Centers Program (NCCCP): Sustaining Quality and Reducing Disparities in Guideline-Concordant Breast and Colon Cancer Care.
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Spain P, Teixeira-Poit S, Halpern MT, Castro K, Prabhu Das I, Adjei B, Lewis R, and Clauser SB
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- Breast Neoplasms drug therapy, Cancer Care Facilities, Colonic Neoplasms drug therapy, Female, Guidelines as Topic, Hospitals, Humans, National Cancer Institute (U.S.), Quality of Health Care, United States, Breast Neoplasms epidemiology, Colonic Neoplasms epidemiology, Healthcare Disparities
- Abstract
Background: The National Cancer Institute Community Cancer Centers Program (NCCCP) pilot was designed to improve quality of cancer care and reduce disparities at community hospitals. The NCCCP's primary intervention was the implementation of the Commission on Cancer Rapid Quality Reporting System (RQRS). The RQRS is a hospital-based data collection and evaluation system allowing near real-time assessment of selected breast and colon cancer quality of care measures. Building on previous NCCCP analyses, this study examined whether improvements in quality cancer care within NCCCP hospitals early in the program were sustained and whether improvements were notable for minority or underserved populations., Methods: We compared changes in concordance with three breast and two colon cancer quality measures approved by the National Quality Forum for patients diagnosed at NCCCP hospitals from 2006 to 2007 (pre-RQRS), 2008 to 2010 (early-RQRS), and 2011 to 2013 (later-RQRS). Data were obtained from NCCCP sites participating in the Commission on Cancer Rapid Quality Reporting System. Logistic regression analyses were performed to identify predictors of concordance with breast and colon cancer quality measures., Results: The sample included 13,893 breast and 5,546 colon cancer patients. After RQRS initiation, all five quality measures improved significantly and improvements were sustained through 2013. Quality of care measures showed sustained improvements for both breast and colon cancer patients and for vulnerable patient subgroups including black, uninsured, and Medicaid-covered patients., Conclusions: Quality improvements in NCCCP hospitals were sustained throughout the duration of the program, both overall and among minority and underserved patients. Because many individuals receive cancer treatment at community hospitals, facilitating high-quality care in these environments must be a priority., Implications for Practice: Quality improvement programs often improve practice, but the methods are not maintained over time. The implementation of a real-time quality reporting system and a network focused on improving quality of care sustained quality improvement at select community cancer centers. The NCCCP pilot increased numbers of patients receiving guideline-concordant care for breast and colon cancer in community settings, and initial improvements noted in earlier years of RQRS were sustained into later years, both overall and among minority and underserved patients. National initiatives that improve care for diverse patient groups are important for reducing and eliminating barriers to care., (© AlphaMed Press 2017.)
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- 2017
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15. Cancer Care Coordination: a Systematic Review and Meta-Analysis of Over 30 Years of Empirical Studies.
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Gorin SS, Haggstrom D, Han PKJ, Fairfield KM, Krebs P, and Clauser SB
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- Humans, Delivery of Health Care organization & administration, Neoplasms therapy, Outcome and Process Assessment, Health Care statistics & numerical data, Patient Care methods
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Background: According to a landmark study by the Institute of Medicine, patients with cancer often receive poorly coordinated care in multiple settings from many providers. Lack of coordination is associated with poor symptom control, medical errors, and higher costs., Purpose: The aims of this systematic review and meta-analysis were to (1) synthesize the findings of studies addressing cancer care coordination, (2) describe study outcomes across the cancer continuum, and (3) obtain a quantitative estimate of the effect of interventions in cancer care coordination on service system processes and patient health outcomes., Methods: Of 1241 abstracts identified through MEDLINE, EMBASE, CINAHL, and the Cochrane Library, 52 studies met the inclusion criteria. Each study had US or Canadian participants, comparison or control groups, measures, times, samples, and/or interventions. Two researchers independently applied a standardized search strategy, coding scheme, and online coding program to each study. Eleven studies met the additional criteria for the meta-analysis; a random effects estimation model was used for data analysis., Results: Cancer care coordination approaches led to improvements in 81 % of outcomes, including screening, measures of patient experience with care, and quality of end-of-life care. Across the continuum of cancer care, patient navigation was the most frequent care coordination intervention, followed by home telehealth; nurse case management was third in frequency. The meta-analysis of a subset of the reviewed studies showed that the odds of appropriate health care utilization in cancer care coordination interventions were almost twice (OR = 1.9, 95 % CI = 1.5-3.5) that of comparison interventions., Conclusions: This review offers promising findings on the impact of cancer care coordination on increasing value and reducing healthcare costs in the USA.
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- 2017
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16. The rationale for patient-reported outcomes surveillance in cancer and a reproducible method for achieving it.
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Smith TG, Castro KM, Troeschel AN, Arora NK, Lipscomb J, Jones SM, Treiman KA, Hobbs C, McCabe RM, and Clauser SB
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- Adult, Aged, Fatigue etiology, Female, Humans, International Cooperation, Male, Middle Aged, National Cancer Institute (U.S.), Pain etiology, Patient Selection, Reproducibility of Results, Sampling Studies, Stress, Psychological etiology, Treatment Outcome, United States, Breast Neoplasms complications, Breast Neoplasms psychology, Breast Neoplasms therapy, Colonic Neoplasms complications, Colonic Neoplasms psychology, Colonic Neoplasms therapy, Patient Outcome Assessment, Patient Satisfaction, Population Surveillance methods, Quality of Health Care, Quality of Life, Self Report
- Abstract
Patient-reported outcomes (PROs) measure quality of life, symptoms, patient functioning, and patient perceptions of care; they are essential for gaining a full understanding of cancer care and the impact of cancer on people's lives. Repeatedly captured facility-level and/or population-level PROs (PRO surveillance) could play an important role in quality monitoring and improvement, benchmarking, advocacy, policy making, and research. This article describes the rationale for PRO surveillance and the methods of the Patient Reported Outcomes Symptoms and Side Effects Study (PROSSES), which is the first PRO study to use the American College of Surgeons Commission on Cancer's Rapid Quality Reporting System to identify patients and manage study data flow. The American Cancer Society, the National Cancer Institute, the Commission on Cancer, and RTI International collaborated on PROSSES. PROSSES was conducted at 17 cancer programs that participated in the National Cancer Institute Community Cancer Centers Program among patients diagnosed with locoregional breast or colon cancer. The methods piloted in PROSSES were successful as demonstrated by high eligibility (93%) and response (61%) rates. Differences in clinical and demographic characteristics between respondents and nonrespondents were mostly negligible, with the exception that non-white individuals were somewhat less likely to respond. These methods were consistent across cancer centers and reproducible over time. If repeated and expanded, they could provide PRO surveillance data from patients with cancer on a national scale., (© 2015 American Cancer Society.)
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- 2016
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17. ReCAP: Impact of Multidisciplinary Care on Processes of Cancer Care: A Multi-Institutional Study.
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Onukwugha E, Petrelli NJ, Castro KM, Gardner JF, Jayasekera J, Goloubeva O, Tan MT, McNamara EJ, Zaren HA, Asfeldt T, Bearden JD 3rd, Salner AL, Krasna MJ, Das IP, Clauser SB, Onukwugha E, Petrelli NJ, Castro KM, Gardner JF, Jayasekera J, Goloubeva O, Tan MT, McNamara EJ, Zaren HA, Asfeldt T, Bearden JD 3rd, Salner AL, Krasna MJ, Prabhu Das I, and Clauser SB
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- Adolescent, Adult, Aged, Aged, 80 and over, Cancer Care Facilities, Combined Modality Therapy, Female, Guideline Adherence, Humans, Male, Middle Aged, Neoplasm Staging, Neoplasms epidemiology, Patient Care Planning, Prospective Studies, Retrospective Studies, Time-to-Treatment, Young Adult, Neoplasms diagnosis, Neoplasms therapy, Patient Care methods, Patient Care standards, Patient Care Team
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Purpose: The role of multidisciplinary care (MDC) on cancer care processes is not fully understood. We investigated the impact of MDC on the processes of care at cancer centers within the National Cancer Institute Community Cancer Centers Program (NCCCP)., Methods: The study used data from patients diagnosed with stage IIB to III rectal cancer, stage III colon cancer, and stage III non–small-cell lung cancer at 14 NCCCP cancer centers from 2007 to 2012. We used an MDC development assessment tool—with levels ranging from evolving MDC (low) to achieving excellence (high)—to measure the level of MDC implementation in seven MDC areas, such as case planning and physician engagement. Descriptive statistics and cluster-adjusted regression models quantified the association between MDC implementation and processes of care, including time from diagnosis to treatment receipt., Results: A total of 1,079 patients were examined. Compared with patients with colon cancer treated at cancer centers reporting low MDC scores, time to treatment receipt was shorter for patients with colon cancer treated at cancer centers reporting high or moderate MDC scores for physician engagement (hazard ratio [HR] for high physician engagement, 2.66; 95% CI, 1.70 to 4.17; HR for moderate physician engagement, 1.50; 95% CI, 1.19 to 1.89) and longer for patients with colon cancer treated at cancer centers reporting high 2MDC scores for case planning (HR, 0.65; 95% CI, 0.49 to 0.85). Results for patients with rectal cancer were qualitatively similar, and there was no statistically significant difference among patients with lung cancer., Conclusion: MDC implementation level was associated with processes of care, and direction of association varied across MDC assessment areas., (Copyright © 2015 by American Society of Clinical Oncology.)
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- 2016
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18. Revisiting the Surveillance Epidemiology and End Results Cancer Registry and Medicare Health Outcomes Survey (SEER-MHOS) Linked Data Resource for Patient-Reported Outcomes Research in Older Adults with Cancer.
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Kent EE, Malinoff R, Rozjabek HM, Ambs A, Clauser SB, Topor MA, Yuan G, Burroughs J, Rodgers AB, and DeMichele K
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- Aged, Aged, 80 and over, Comorbidity, Female, Health Status Disparities, Humans, Male, Patient Outcome Assessment, Prevalence, Quality Improvement, SEER Program, United States epidemiology, Health Care Rationing methods, Health Care Rationing statistics & numerical data, Health Services for the Aged statistics & numerical data, Medical Record Linkage methods, Medicare statistics & numerical data, Neoplasms diagnosis, Neoplasms epidemiology, Neoplasms psychology, Neoplasms therapy, Quality of Life
- Abstract
Researchers and clinicians are increasingly recognizing the value of patient-reported outcome (PRO) data to better characterize people's health and experiences with illness and care. Considering the rising prevalence of cancer in adults aged 65 and older, PRO data are particularly relevant for older adults with cancer, who often require complex cancer care and have additional comorbid conditions. A data linkage between the Surveillance Epidemiology and End Results (SEER) cancer registry and the Medicare Health Outcomes Survey (MHOS) was created through a partnership between the National Cancer Institute and the Centers for Medicare and Medicaid Services that created the opportunity to examine PROs in Medicare Advantage enrollees with and without cancer. The December 2013 linkage of SEER-MHOS data included the linked data for 12 cohorts, bringing the number of individuals in the linked data set to 95,723 with cancer and 1,510,127 without. This article reviews the features of the resource and provides information on some descriptive characteristics of the individuals in the data set (health-related quality of life, body mass index, fall risk management, number of unhealthy days in the past month). Individuals without (n=258,108) and with (n=3,440) cancer (1,311 men with prostate cancer, 982 women with breast cancer, 689 with colorectal cancer, 458 with lung cancer) were included in the current descriptive analysis. Given increasing longevity, advances in effective therapies and earlier detection, and population growth, the number of individuals aged 65 and older with cancer is expected to reach more than 12 million by 2020. SEER-MHOS provides population-level, self-reported, cancer registry-linked data for person-centered surveillance research on this growing population., (© 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics Society.)
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- 2016
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19. Validity and Reliability of the US National Cancer Institute's Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE).
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Dueck AC, Mendoza TR, Mitchell SA, Reeve BB, Castro KM, Rogak LJ, Atkinson TM, Bennett AV, Denicoff AM, O'Mara AM, Li Y, Clauser SB, Bryant DM, Bearden JD 3rd, Gillis TA, Harness JK, Siegel RD, Paul DB, Cleeland CS, Schrag D, Sloan JA, Abernethy AP, Bruner DW, Minasian LM, and Basch E
- Subjects
- Adult, Aged, Aged, 80 and over, Ambulatory Care, Computers, Handheld, Drug-Related Side Effects and Adverse Reactions etiology, Female, Humans, Male, Middle Aged, Neoplasms diagnosis, Quality of Life, Radiation Injuries etiology, Radiotherapy adverse effects, Reproducibility of Results, Self Report, Time Factors, Treatment Outcome, United States, Young Adult, Adverse Drug Reaction Reporting Systems classification, Antineoplastic Agents adverse effects, Chemoradiotherapy adverse effects, Drug-Related Side Effects and Adverse Reactions classification, National Cancer Institute (U.S.), Neoplasms drug therapy, Neoplasms radiotherapy, Radiation Injuries classification, Surveys and Questionnaires, Terminology as Topic
- Abstract
Importance: To integrate the patient perspective into adverse event reporting, the National Cancer Institute developed a patient-reported outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE)., Objective: To assess the construct validity, test-retest reliability, and responsiveness of PRO-CTCAE items., Design, Setting, and Participants: A total of 975 adults with cancer undergoing outpatient chemotherapy and/or radiation therapy enrolled in this questionnaire-based study between January 2011 and February 2012. Eligible participants could read English and had no clinically significant cognitive impairment. They completed PRO-CTCAE items on tablet computers in clinic waiting rooms at 9 US cancer centers and community oncology practices at 2 visits 1 to 6 weeks apart. A subset completed PRO-CTCAE items during an additional visit 1 business day after the first visit., Main Outcomes and Measures: Primary comparators were clinician-reported Eastern Cooperative Oncology Group Performance Status (ECOG PS) and the European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (QLQ-C30)., Results: A total of 940 of 975 (96.4%) and 852 of 940 (90.6%) participants completed PRO-CTCAE items at visits 1 and 2, respectively. At least 1 symptom was reported by 938 of 940 (99.8%) participants. Participants' median age was 59 years; 57.3% were female, 32.4% had a high school education or less, and 17.1% had an ECOG PS of 2 to 4. All PRO-CTCAE items had at least 1 correlation in the expected direction with a QLQ-C30 scale (111 of 124, P<.05 for all). Stronger correlations were seen between PRO-CTCAE items and conceptually related QLQ-C30 domains. Scores for 94 of 124 PRO-CTCAE items were higher in the ECOG PS 2 to 4 vs 0 to 1 group (58 of 124, P<.05 for all). Overall, 119 of 124 items met at least 1 construct validity criterion. Test-retest reliability was 0.7 or greater for 36 of 49 prespecified items (median [range] intraclass correlation coefficient, 0.76 [0.53-.96]). Correlations between PRO-CTCAE item changes and corresponding QLQ-C30 scale changes were statistically significant for 27 prespecified items (median [range] r=0.43 [0.10-.56]; all P≤.006)., Conclusions and Relevance: Evidence demonstrates favorable validity, reliability, and responsiveness of PRO-CTCAE in a large, heterogeneous US sample of patients undergoing cancer treatment. Studies evaluating other measurement properties of PRO-CTCAE are under way to inform further development of PRO-CTCAE and its inclusion in cancer trials.
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- 2015
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20. Cancer Care Delivery Research: Building the Evidence Base to Support Practice Change in Community Oncology.
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Kent EE, Mitchell SA, Castro KM, DeWalt DA, Kaluzny AD, Hautala JA, Grad O, Ballard RM, McCaskill-Stevens WJ, Kramer BS, and Clauser SB
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- Humans, Research, Delivery of Health Care methods, Health Services Research methods, Medical Oncology methods
- Abstract
Understanding how health care system structures, processes, and available resources facilitate and/or hinder the delivery of quality cancer care is imperative, especially given the rapidly changing health care landscape. The emerging field of cancer care delivery research (CCDR) focuses on how organizational structures and processes, care delivery models, financing and reimbursement, health technologies, and health care provider and patient knowledge, attitudes, and behaviors influence cancer care quality, cost, and access and ultimately the health outcomes and well-being of patients and survivors. In this article, we describe attributes of CCDR, present examples of studies that illustrate those attributes, and discuss the potential impact of CCDR in addressing disparities in care. We conclude by emphasizing the need for collaborative research that links academic and community-based settings and serves simultaneously to accelerate the translation of CCDR results into practice. The National Cancer Institute recently launched its Community Oncology Research Program, which includes a focus on this area of research., (© 2015 by American Society of Clinical Oncology.)
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- 2015
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21. Patient characteristics associated with the level of patient-reported care coordination among male patients with colorectal cancer in the Veterans Affairs health care system.
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Jackson GL, Zullig LL, Phelan SM, Provenzale D, Griffin JM, Clauser SB, Haggstrom DA, Jindal RM, and van Ryn M
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- Aged, Healthcare Disparities statistics & numerical data, Humans, Male, Treatment Outcome, United States, Colorectal Neoplasms diagnosis, Colorectal Neoplasms ethnology, Patient Care methods, United States Department of Veterans Affairs statistics & numerical data, Veterans statistics & numerical data
- Abstract
Background: The current study was performed to determine whether patient characteristics, including race/ethnicity, were associated with patient-reported care coordination for patients with colorectal cancer (CRC) who were treated in the Veterans Affairs (VA) health care system, with the goal of better understanding potential goals of quality improvement efforts aimed at improving coordination., Methods: The nationwide Cancer Care Assessment and Responsive Evaluation Studies survey involved VA patients with CRC who were diagnosed in 2008 (response rate, 67%). The survey included a 4-item scale of patient-reported frequency ("never," "sometimes," "usually," and "always") of care coordination activities (scale score range, 1-4). Among 913 patients with CRC who provided information regarding care coordination, demographics, and symptoms, multivariable logistic regression was used to examine odds of patients reporting optimal care coordination., Results: VA patients with CRC were found to report high levels of care coordination (mean scale score, 3.50 [standard deviation, 0.61]). Approximately 85% of patients reported a high level of coordination, including the 43% reporting optimal/highest-level coordination. There was no difference observed in the odds of reporting optimal coordination by race/ethnicity. Patients with early-stage disease (odds ratio [OR], 0.60; 95% confidence interval [95% CI], 0.45-0.81), greater pain (OR, 0.97 for a 1-point increase in pain scale; 95% CI, 0.96-0.99), and greater levels of depression (OR, 0.97 for a 1-point increase in depression scale; 95% CI, 0.96-0.99) were less likely to report optimal coordination., Conclusions: Patients with CRC in the VA reported high levels of care coordination. Unlike what has been reported in settings outside the VA, there appears to be no racial/ethnic disparity in reported coordination. However, challenges remain in ensuring coordination of care for patients with less advanced disease and a high symptom burden. Cancer 2015;121:2207-2213. © 2015 American Cancer Society., (© 2015 American Cancer Society.)
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- 2015
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22. Walking in the shoes of patients, not just in their genes: a patient-centered approach to genomic medicine.
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Arora NK, Hesse BW, and Clauser SB
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- Breast Neoplasms psychology, Communication, Decision Making, Gene Expression Profiling, Humans, Self Care, Uncertainty, Breast Neoplasms genetics, Breast Neoplasms therapy, Genomics, Patient-Centered Care organization & administration, Professional-Patient Relations
- Abstract
Genomic technologies are increasing the precision with which clinicians can assess an individual patient's risk for developing diseases and identify which patients are likely to benefit from specific treatments. Also advocating for a shift away from a one-size-fits-all approach is the growing emphasis on "patient-centered" care. Using examples from breast cancer, we make a case for why, in order to optimize patient health outcomes, genomic medicine will need to be practiced within a patient-centered framework. We present a six-function conceptual framework for patient-centered care and discuss findings from a national survey evaluating the patient-centeredness of care delivered in the USA.
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- 2015
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23. Patient Centeredness and Engagement in Quality-of-Care Oncology Research.
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Clauser SB, Gayer C, Murphy E, Majhail NS, and Baker KS
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- Academies and Institutes, Community-Institutional Relations, Comparative Effectiveness Research standards, Cooperative Behavior, Humans, Interdisciplinary Communication, Patient Care Team standards, Delivery of Health Care standards, Health Services Research standards, Medical Oncology standards, Patient Participation, Patient-Centered Care standards, Quality Improvement standards, Quality Indicators, Health Care standards
- Abstract
More than a decade after the Institute of Medicine (IOM) first studied the quality of cancer care, obstacles to achieving high-quality care remain, and studies suggest that cancer care is often not as patient centered, accessible, coordinated, or evidence based as it could be. Patients, their families, and clinicians face a wide range of complex and often confusing choices regarding their health and health care concerns and require trustworthy information to decide which options are best for them. The Patient-Centered Outcomes Research Institute (PCORI) strives to fund clinical comparative effectiveness research, guided by patients, caregivers, and the broader health care community, that will provide high-integrity, evidence-based information to help people make informed health care decisions. This mission is well aligned with the IOM's recent conceptual framework and corresponding recommendations that recognize that addressing the needs of patients with cancer and their families is the most important component of a high-quality cancer care delivery system. PCORI seeks the opportunity to partner with diverse interdisciplinary research teams who demonstrate a strong commitment to the inclusion and engagement of patients and stakeholders as they work to develop high-quality cancer care delivery systems. We see rich opportunities for such partnership in the cancer care community, given the wealth of well-established patient advocacy groups and organizations and cutting-edge research institutions, all of which are working toward the common goal of improving the quality of cancer care for patients and their families. This article and the project it describes provide an example of an avenue for advancing this goal., (Copyright © 2015 by American Society of Clinical Oncology.)
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- 2015
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24. Health-related quality of life in older adult survivors of selected cancers: data from the SEER-MHOS linkage.
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Kent EE, Ambs A, Mitchell SA, Clauser SB, Smith AW, and Hays RD
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- Aged, Female, Humans, Male, Mental Health, Middle Aged, Neoplasms mortality, SEER Program, Surveys and Questionnaires, United States epidemiology, Health Status, Health Surveys, Neoplasms epidemiology, Quality of Life
- Abstract
Background: Research on health-related quality of life (HRQOL) among older adult cancer survivors is mostly confined to breast cancer, prostate cancer, colorectal cancer, and lung cancer, which account for 63% of all prevalent cancers. Much less is known about HRQOL in the context of less common cancer sites., Methods: HRQOL was examined with the 36-Item Short Form Health Survey, version 1, and the Veterans RAND 12-Item Health Survey in patients with selected cancers (kidney cancer, bladder cancer, pancreatic cancer, upper gastrointestinal cancer, cancer of the oral cavity and pharynx, uterine cancer, cervical cancer, thyroid cancer, melanoma, chronic leukemia, non-Hodgkin lymphoma, and multiple myeloma) and in individuals without cancer on the basis of data linked from the Surveillance, Epidemiology, and End Results cancer registry system and the Medicare Health Outcomes Survey. Scale scores, Physical Component Summary (PCS) and Mental Component Summary (MCS) scores, and a utility metric (Short Form 6D/Veterans RAND 6D), adjusted for sociodemographic characteristics and other chronic conditions, were calculated. A 3-point difference in the scale scores and a 2-point difference in the PCS and MCS scores were considered to be minimally important differences., Results: Data from 16,095 cancer survivors and 1,224,549 individuals without a history of cancer were included. The results indicated noteworthy deficits in physical health status. Mental health was comparable, although scores for the Role-Emotional and Social Functioning scales were worse for patients with most types of cancer versus those without cancer. Survivors of multiple myeloma and pancreatic malignancies reported the lowest scores, with their PCS/MCS scores less than those of individuals without cancer by 3 or more points., Conclusions: HRQOL surveillance efforts revealed poor health outcomes among many older adults and specifically among survivors of multiple myeloma and pancreatic cancer., (© 2014 American Cancer Society.)
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- 2015
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25. Quality improvement in the national cancer institute community cancer centers program: the quality oncology practice initiative experience.
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Siegel RD, Castro KM, Eisenstein J, Stallings H, Hegedus PD, Bryant DM, Kadlubek PJ, and Clauser SB
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- National Cancer Institute (U.S.), United States, Cancer Care Facilities standards, Hospitals, Community standards, Quality Improvement
- Abstract
Purpose: The National Cancer Institute (NCI) Community Cancer Centers Program (NCCCP) began in 2007; it is a network of community-based hospitals funded by the NCI. Quality of care is an NCCCP priority, with participation in the American Society of Clinical Oncology Quality Oncology Practice Initiative (QOPI) playing a fundamental role in quality assessment and quality improvement (QI) projects. Using QOPI methodology, performance on quality measures was analyzed two times per year over a 3-year period to enhance our implementation of quality standards at NCCCP hospitals., Methods: A data-sharing agreement allowed individual-practice QOPI data to be electronically sent to the NCI. Aggregated data with the other NCCCP QOPI participants were presented to the network via Webinars. The NCCCP Quality of Care Subcommittee selected areas in which to focus subsequent QI efforts, and high-performing practices shared voluntarily their QI best practices with the network., Results: QOPI results were compiled semiannually between fall 2010 and fall 2013. The network concentrated on measures with a quality score of ≤ 0.75 and planned voluntary group-wide QI interventions. We identified 13 measures in which the NCCCP fell at or below the designated quality score in fall 2010. After implementing a variety of QI initiatives, the network registered improvements in all parameters except one (use of treatment summaries)., Conclusion: Using the NCCCP as a paradigm, QOPI metrics provide a useful platform for group-wide measurement of quality performance. In addition, these measurements can be used to assess the effectiveness of QI initiatives., (Copyright © 2014 by American Society of Clinical Oncology.)
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- 2015
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26. Assessing the Development of Multidisciplinary Care: Experience of the National Cancer Institute Community Cancer Centers Program.
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Friedman EL, Chawla N, Morris PT, Castro KM, Carrigan AC, Das IP, and Clauser SB
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- Cancer Care Facilities, Clinical Trials as Topic statistics & numerical data, Female, Humans, National Cancer Institute (U.S.), Patient Care Team, United States, Breast Neoplasms therapy, Colorectal Neoplasms therapy, Community Health Services organization & administration, Community Health Services standards, Lung Neoplasms therapy, Quality of Health Care
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Purpose: The National Cancer Institute Community Cancer Centers Program (NCCCP) began in 2007 with a goal of expanding cancer research and delivering quality care in communities. The NCCCP Quality of Care (QoC) Subcommittee was charged with developing and improving the quality of multidisciplinary care. An assessment tool with nine key elements relevant to MDC structure and operations was developed., Methods: Fourteen NCCCP sites reported multidisciplinary care assessments for lung, breast, and colorectal cancer in June 2010, June 2011, and June 2012 using an online reporting tool. Each site evaluated their level of maturity (level 1 = no multidisciplinary care, level 5 = highly integrated multidisciplinary care) in nine elements integral to multidisciplinary care. Thematic analysis of open-ended qualitative responses was also conducted., Results: The proportion of sites that reported level 3 or greater on the assessment tool was tabulated at each time point. For all tumor types, sites that reached this level increased in six elements: case planning, clinical trials, integration of care coordination, physician engagement, quality improvement, and treatment team integration. Factors that enabled improvement included increasing organizational support, ensuring appropriate physician participation, increasing patient navigation, increasing participation in national quality initiatives, targeting genetics referrals, engaging primary care providers, and integrating clinical trial staff., Conclusions: Maturation of multidisciplinary care reflected focused work of the NCCCP QoC Subcommittee. Working group efforts in patient navigation, genetics, and physician conditions of participation were evident in improved multidisciplinary care performance for three common malignancies. This work provides a blueprint for health systems that wish to incorporate prospective multidisciplinary care into their cancer programs., (Copyright © 2015 by American Society of Clinical Oncology.)
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- 2015
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27. Development of the National Cancer Institute's patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE).
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Basch E, Reeve BB, Mitchell SA, Clauser SB, Minasian LM, Dueck AC, Mendoza TR, Hay J, Atkinson TM, Abernethy AP, Bruner DW, Cleeland CS, Sloan JA, Chilukuri R, Baumgartner P, Denicoff A, St Germain D, O'Mara AM, Chen A, Kelaghan J, Bennett AV, Sit L, Rogak L, Barz A, Paul DB, and Schrag D
- Subjects
- Humans, National Cancer Institute (U.S.), Patient Outcome Assessment, Surveys and Questionnaires, United States, Adverse Drug Reaction Reporting Systems, Antineoplastic Agents adverse effects, Neoplasms drug therapy, Self Report, Terminology as Topic
- Abstract
The standard approach for documenting symptomatic adverse events (AEs) in cancer clinical trials involves investigator reporting using the National Cancer Institute's (NCI's) Common Terminology Criteria for Adverse Events (CTCAE). Because this approach underdetects symptomatic AEs, the NCI issued two contracts to create a patient-reported outcome (PRO) measurement system as a companion to the CTCAE, called the PRO-CTCAE. This Commentary describes development of the PRO-CTCAE by a group of multidisciplinary investigators and patient representatives and provides an overview of qualitative and quantitative studies of its measurement properties. A systematic evaluation of all 790 AEs listed in the CTCAE identified 78 appropriate for patient self-reporting. For each of these, a PRO-CTCAE plain language term in English and one to three items characterizing the frequency, severity, and/or activity interference of the AE were created, rendering a library of 124 PRO-CTCAE items. These items were refined in a cognitive interviewing study among patients on active cancer treatment with diverse educational, racial, and geographic backgrounds. Favorable measurement properties of the items, including construct validity, reliability, responsiveness, and between-mode equivalence, were determined prospectively in a demographically diverse population of patients receiving treatments for many different tumor types. A software platform was built to administer PRO-CTCAE items to clinical trial participants via the internet or telephone interactive voice response and was refined through usability testing. Work is ongoing to translate the PRO-CTCAE into multiple languages and to determine the optimal approach for integrating the PRO-CTCAE into clinical trial workflow and AE analyses. It is envisioned that the PRO-CTCAE will enhance the precision and patient-centeredness of adverse event reporting in cancer clinical research., (© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
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- 2014
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28. Discussions about clinical trials among patients with newly diagnosed lung and colorectal cancer.
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Kehl KL, Arora NK, Schrag D, Ayanian JZ, Clauser SB, Klabunde CN, Kahn KL, Fletcher RH, and Keating NL
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- Black or African American statistics & numerical data, Age Factors, Aged, Aged, 80 and over, Asian statistics & numerical data, Choice Behavior, Clinical Trials as Topic, Cohort Studies, Colorectal Neoplasms pathology, Colorectal Neoplasms therapy, Comorbidity, Female, Humans, Income, Information Seeking Behavior, Lung Neoplasms pathology, Lung Neoplasms therapy, Male, Middle Aged, Neoplasm Staging, Patient Participation, Surveys and Questionnaires, United States, White People statistics & numerical data, Colorectal Neoplasms diagnosis, Communication, Decision Making, Lung Neoplasms diagnosis, Patient Selection
- Abstract
Background: Clinical trials are essential to establish the effectiveness of new cancer therapies, but less than 5% of adults with cancer enroll in trials. In addition to ineligibility or lack of available trials, barriers to enrollment may include limited patient awareness about the option of participation., Methods: We surveyed a multiregional cohort of patients with lung or colorectal cancer (or their surrogates) three to six months after diagnosis. We assessed whether respondents reported learning that clinical trial participation might be an option, and, if so, with whom they discussed trials. We used logistic regression to assess the association of patient characteristics with discussing trial participation and enrolling in trials. All statistical tests were two-sided., Results: Of 7887 respondents, 1114 (14.1%) reported discussing the possibility of clinical trial participation; most learned about trials from their physicians, and 287 patients (3.6% of all patients, 25.8% of trial discussants) enrolled. Among 2173 patients who received chemotherapy for advanced (stage III/IV lung or stage IV colorectal) cancer, 25.7% discussed trials, and 7.6% (29.5% of trial discussants) enrolled. Discussions were less frequent among older patients, African American or Asian vs white patients, and those with lower incomes and more comorbidity. Enrollment was higher among patients reporting shared vs physician-driven decisions (all P < .05)., Conclusions: In this population-based cohort, only 14% of patients discussed participation in clinical trials. Discussions were more frequent among advanced cancer patients but were still reported by a minority of patients. Strategies to expand access to trials and facilitate patient-provider communication about participation may accelerate development of better cancer therapeutics., (© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
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- 2014
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29. Patient-reported quality of supportive care among patients with colorectal cancer in the Veterans Affairs Health Care System.
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van Ryn M, Phelan SM, Arora NK, Haggstrom DA, Jackson GL, Zafar SY, Griffin JM, Zullig LL, Provenzale D, Yeazel MW, Jindal RM, and Clauser SB
- Subjects
- Aged, Aged, 80 and over, Colorectal Neoplasms diagnosis, Colorectal Neoplasms ethnology, Colorectal Neoplasms psychology, Cross-Sectional Studies, Delivery of Health Care, Integrated standards, Female, Health Services Accessibility standards, Health Surveys, Humans, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Patient-Centered Care standards, Quality of Life, Registries, Surveys and Questionnaires, Treatment Outcome, United States, Colorectal Neoplasms therapy, Comprehensive Health Care standards, Hospitals, Veterans, Medical Oncology standards, Patient Satisfaction, Quality of Health Care standards, United States Department of Veterans Affairs
- Abstract
Purpose: High-quality supportive care is an essential component of comprehensive cancer care. We implemented a patient-centered quality of cancer care survey to examine and identify predictors of quality of supportive care for bowel problems, pain, fatigue, depression, and other symptoms among 1,109 patients with colorectal cancer., Patients and Methods: Patients with new diagnosis of colorectal cancer at any Veterans Health Administration medical center nationwide in 2008 were ascertained through the Veterans Affairs Central Cancer Registry and sent questionnaires assessing a variety of aspects of patient-centered cancer care. We received questionnaires from 63% of eligible patients (N = 1,109). Descriptive analyses characterizing patient experiences with supportive care and binary logistic regression models were used to examine predictors of receipt of help wanted for each of the five symptom categories., Results: There were significant gaps in patient-centered quality of supportive care, beginning with symptom assessment. In multivariable modeling, the impact of clinical factors and patient race on odds of receiving wanted help varied by symptom. Coordination of care quality predicted receipt of wanted help for all symptoms, independent of patient demographic or clinical characteristics., Conclusion: This study revealed substantial gaps in patient-centered quality of care, difficult to characterize through quality measurement relying on medical record review alone. It established the feasibility of collecting patient-reported quality measures. Improving quality measurement of supportive care and implementing patient-reported outcomes in quality-measurement systems are high priorities for improving the processes and outcomes of care for patients with cancer.
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- 2014
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30. Associations of cancer and other chronic medical conditions with SF-6D preference-based scores in Medicare beneficiaries.
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Hays RD, Reeve BB, Smith AW, and Clauser SB
- Subjects
- Aged, Aged, 80 and over, Chronic Disease, Comorbidity, Female, Health Surveys, Humans, Male, Medicare, Neoplasms epidemiology, SEER Program, United States epidemiology, Neoplasms physiopathology, Neoplasms psychology, Quality of Life, Sickness Impact Profile
- Abstract
Purpose: Documenting the impact of different types of cancer on daily functioning and well-being is important for understanding burden relative to other chronic medical conditions. This study examined the impact of 10 different cancers and 13 other chronic medical conditions on health-related quality of life., Methods: Health-related quality of life data were gathered on the Medicare Health Outcomes Survey (MHOS) between 1998 and 2002. Cancer information was ascertained using the National Cancer Institute's surveillance, epidemiology, and end results program and linked to MHOS data., Results: The average SF-6D score was 0.73 (SD = 0.14). Depressive symptoms had the largest unique association with the SF-6D, followed by arthritis of the hip, chronic obstructive pulmonary disease/asthma, stroke, and sciatica. In addition, the majority of cancer types were significantly associated with the SF-6D score, with significant negative weights ranging from -0.01 to -0.02 on the 0-1 health utility scale. Distant stage of cancer was associated with large decrements in the SF-6D ranging from -0.04 (prostate) to -0.08 (female breast)., Conclusion: A large number of chronic conditions, including cancer, are associated uniquely with decrements in health utility. The cumulative effects of comorbid conditions have substantial impact on daily functioning and well-being of Medicare beneficiaries.
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- 2014
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31. Cognitive interviewing of the US National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE).
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Hay JL, Atkinson TM, Reeve BB, Mitchell SA, Mendoza TR, Willis G, Minasian LM, Clauser SB, Denicoff A, O'Mara A, Chen A, Bennett AV, Paul DB, Gagne J, Rogak L, Sit L, Viswanath V, Schrag D, and Basch E
- Subjects
- Adverse Drug Reaction Reporting Systems standards, Antineoplastic Agents adverse effects, Antineoplastic Agents toxicity, Cognition Disorders complications, Cognition Disorders etiology, Drug Labeling standards, Female, Humans, Male, Neoplasms diagnosis, Neoplasms drug therapy, Neoplasms radiotherapy, Outcome and Process Assessment, Health Care methods, Psychometrics, Reproducibility of Results, Terminology as Topic, United States, Cognition Disorders psychology, Drug-Related Side Effects and Adverse Reactions classification, Interview, Psychological methods, Interview, Psychological standards, National Cancer Institute (U.S.), Self Report
- Abstract
Purpose: The National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) is a library of question items that enables patient reporting of adverse events (AEs) in clinical trials. This study contributes content validity evidence of the PRO-CTCAE by incorporating cancer patient input of the relevance and comprehensiveness of the item library., Methods: Cognitive interviews were conducted among patients undergoing chemotherapy or radiation therapy at multiple sites to evaluate comprehension, memory retrieval, judgment, and response mapping related to AE terms (e.g., nausea), attribute terms (regarding frequency, severity, or interference), response options, and recall period. Three interview rounds were conducted with ≥20 patients completing each item per round. Items were modified and retested if ≥3 patients exhibited cognitive difficulties or if experienced by ≤25% patients., Results: One hundred and twenty-seven patients participated (35% ≤high school, 28% non-white, and 59% female). Most AE terms (63/80) generated no cognitive difficulties. The remaining 17 were modified without further difficulties by Round 3. Terms were comprehended regardless of education level. Attribute terms and response options required no modifications. Patient adherence to recall period (7 days) was improved when the reference period was incorporated., Conclusions: This study provides evidence confirming comprehension of the US English language versions of items in the PRO-CTCAE library for measuring symptomatic AEs from the patient perspective within the context of cancer treatment. Several minor changes were made to the items to improve item clarity, comprehension, and ease of response judgment. This study helps to establish the content validity of PRO-CTCAE items for patient reporting of AEs during cancer treatment.
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- 2014
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32. Organization of primary care practice for providing energy balance care.
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Klabunde CN, Clauser SB, Liu B, Pronk NP, Ballard-Barbash R, Huang TT, and Smith AW
- Subjects
- Body Mass Index, Data Collection, Diet, Energy Metabolism, Humans, Motor Activity, Practice Patterns, Physicians' organization & administration, Practice Patterns, Physicians' statistics & numerical data, Primary Health Care methods, Primary Health Care statistics & numerical data, Surveys and Questionnaires, United States epidemiology, Obesity prevention & control, Primary Health Care organization & administration
- Abstract
Purpose: Primary care physicians (PCPs) may not adequately counsel or monitor patients regarding diet, physical activity, and weight control (i.e., provide energy balance care). We assessed the organization of PCPs' practices for providing this care., Design: The study design was a nationally representative survey conducted in 2008., Setting: The study setting was U.S. primary care practices., Subjects: A total of 1740 PCPs completed two sequential questionnaires (response rate, 55.5%)., Measures: The study measured PCPs' reports of practice resources, and the frequency of body mass index assessment, counseling, referral for further evaluation/management, and monitoring of patients for energy balance care., Analysis: Descriptive statistics and logistic regression modeling were used., Results: More than 80% of PCPs reported having information resources on diet, physical activity, or weight control available in waiting/exam rooms, but fewer billed (45%), used reminder systems (<30%), or received incentive payments (3%) for energy balance care. A total of 26% reported regularly assessing body mass index and always/often providing counseling as well as tracking patients for progress related to energy balance. In multivariate analyses, PCPs in practices with full electronic health records or those that bill for energy balance care provided this care more often and more comprehensively. There were strong specialty differences, with pediatricians more likely (odds ratio, 1.78; 95% confidence interval, 1.26-2.51) and obstetrician/gynecologists less likely (odds ratio, 0.28; 95% confidence interval, 0.17-0.44) than others to provide energy balance care., Conclusion: PCPs' practices are not well organized for providing energy balance care. Further research is needed to understand PCP care-related specialty differences.
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- 2014
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33. Physicians' attitudes about communicating and managing scientific uncertainty differ by perceived ambiguity aversion of their patients.
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Portnoy DB, Han PK, Ferrer RA, Klein WM, and Clauser SB
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- Adult, Communication, Data Collection, Female, Humans, Male, Patient Participation psychology, Physicians psychology, Attitude of Health Personnel, Physician-Patient Relations, Uncertainty
- Abstract
Background: Medical interventions are often characterized by substantial scientific uncertainty regarding their benefits and harms. Physicians must communicate to their patients as part of the process of shared decision making, yet they may not always communicate scientific uncertainty for several reasons. One suggested by past research is individual differences in physicians' tolerance of uncertainty. Relatedly, an unexplored explanation is physicians' beliefs about their patients' tolerance of uncertainty., Design: To test this possibility, we surveyed a sample of primary care physicians (N = 1500) and examined the association between their attitudes about communicating and managing scientific uncertainty and their perceptions of negative reactions to uncertainty by their patients. Physician perceptions were measured by their propensity towards pessimistic appraisals of risk information and avoidance of decision making when risk information is ambiguous--of uncertain reliability, credibility or adequacy, known as 'ambiguity aversion'., Results: Confirming past studies, physician demographics (e.g. medical specialty) predicted attitudes toward communicating scientific uncertainty. Additionally, physicians' beliefs about their patients' ambiguity aversion significantly predicted these preferences. Physicians who thought that more of their patients would have negative reactions to ambiguous information were more likely to think that they should decide what is best for their patients (β = 0.065, P = 0.013), and to withhold an intervention that had uncertainty associated with it (β = 0.170, P < 0.001)., Discussion: When faced with the task of communicating scientific uncertainty about medical tests and treatments, physicians' perceptions of their patients' ambiguity aversion may be related to their attitudes towards communicating uncertainty., (© 2011 John Wiley & Sons Ltd.)
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- 2013
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34. Impact of diagnosis and treatment of clinically localized prostate cancer on health-related quality of life for older Americans: a population-based study.
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Reeve BB, Stover AM, Jensen RE, Chen RC, Taylor KL, Clauser SB, Collins SP, and Potosky AL
- Subjects
- Aged, Aged, 80 and over, Humans, Male, Prostatectomy, Prostatic Neoplasms psychology, Prostatic Neoplasms radiotherapy, SEER Program, Activities of Daily Living psychology, Depressive Disorder, Major psychology, Health Status, Prostatic Neoplasms diagnosis, Prostatic Neoplasms therapy, Quality of Life
- Abstract
Background: Few studies have measured longitudinal changes in health-related quality of life (HRQOL) among patients with prostate cancer starting before their cancer diagnosis or have provided simultaneous comparisons with a matched noncancer cohort. In the current study, the authors addressed these gaps by providing unique estimates of the effects of a cancer diagnosis on HRQOL accounting for the confounding effects of ageing and comorbidity., Methods: Data from the Surveillance, Epidemiology, and End Results registry were linked with Medicare Health Outcomes Survey (MHOS) data. Eligible patients (n = 445) were Medicare beneficiaries aged ≥65 years from 1998 to 2003 whose first prostate cancer diagnosis occurred between their baseline and follow-up MHOS. By using propensity score matching, 2225 participants without cancer were identified from the MHOS data. Analysis of covariance models were used to estimate changes in HRQOL as assessed with the Medical Outcomes Study Short Form-36 survey and the activities of daily living scale., Results: Before diagnosis, patients with prostate cancer reported HRQOL similar to that of men without cancer. After diagnosis, men with prostate cancer experienced significant decrements in physical, mental, and social aspects of their lives relative to controls, especially within the first 6 months after diagnosis. For men who were surveyed beyond 1 year after diagnosis, HRQOL was similar to that for controls. However, an increased risk for major depressive disorder was observed among men who received either conservative management or external beam radiation., Conclusions: The current findings illustrated the time-sensitive nature of decline in HRQOL after a cancer diagnosis and enhanced understanding of the impact of prostate cancer diagnosis and treatment on physical, mental, and social well being among older men., (Copyright © 2012 American Cancer Society.)
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- 2012
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35. Knowledge of energy balance guidelines and associated clinical care practices: the U.S. National Survey of Energy Balance Related Care among Primary Care Physicians.
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Pronk NP, Krebs-Smith SM, Galuska DA, Liu B, Kushner RF, Troiano RP, Clauser SB, Ballard-Barbash R, and Smith AW
- Subjects
- Adolescent, Adult, Aged, Body Mass Index, Child, Diet psychology, Diet standards, Exercise psychology, Female, Health Care Surveys, Humans, Male, Middle Aged, Physicians, Family education, Physicians, Family statistics & numerical data, Sex Distribution, Socioeconomic Factors, Surveys and Questionnaires, United States, Energy Intake, Health Knowledge, Attitudes, Practice, Outcome and Process Assessment, Health Care, Physicians, Family psychology, Practice Guidelines as Topic, Practice Patterns, Physicians' statistics & numerical data, Primary Health Care standards
- Abstract
Objective: To assess primary care physicians' (PCPs) knowledge of energy balance related guidelines and the association with sociodemographic characteristics and clinical care practices., Method: As part of the 2008 U.S. nationally representative National Survey of Energy Balance Related Care among Primary Care Physicians (EB-PCP), 1776 PCPs from four specialties who treated adults (n=1060) or children and adolescents (n=716) completed surveys on sociodemographic information, knowledge of energy balance guidelines, and clinical care practices., Results: EB-PCP response rate was 64.5%. For PCPs treating children, knowledge of guidelines for healthy BMI percentile, physical activity, and fruit and vegetables intake was 36.5%, 27.0%, and 62.9%, respectively. For PCPs treating adults, knowledge of guidelines for overweight, obesity, physical activity, and fruit and vegetables intake was 81.4%, 81.3%, 70.9%, and 63.5%, respectively. Generally, younger, female physicians were more likely to exhibit correct knowledge. Knowledge of weight-related guidelines was associated with assessment of body mass index (BMI) and use of BMI-for-age growth charts., Conclusion: Knowledge of energy balance guidelines among PCPs treating children is low, among PCPs treating adults it appeared high for overweight and obesity-related clinical guidelines and moderate for physical activity and diet, and was mostly unrelated to clinical practices among all PCPs., (Copyright © 2012 Elsevier Inc. All rights reserved.)
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- 2012
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36. Multilevel research and the challenges of implementing genomic medicine.
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Khoury MJ, Coates RJ, Fennell ML, Glasgow RE, Scheuner MT, Schully SD, Williams MS, and Clauser SB
- Subjects
- Colorectal Neoplasms, Hereditary Nonpolyposis diagnosis, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, Evidence-Based Medicine, Health Policy, Health Services Research methods, Humans, Interdisciplinary Communication, Medicaid, Medicare, Mutation, Neoplasms therapy, Physicians standards, Practice Patterns, Physicians' standards, Practice Patterns, Physicians' trends, Precision Medicine, Quality of Health Care standards, Quality of Health Care trends, Research Design, United States, Continuity of Patient Care organization & administration, Continuity of Patient Care standards, Continuity of Patient Care trends, Delivery of Health Care, Integrated economics, Delivery of Health Care, Integrated standards, Delivery of Health Care, Integrated trends, Genetic Testing, Genomics, Neoplasms diagnosis, Neoplasms genetics, Patient Care Team standards, Patient Care Team trends, Translational Research, Biomedical methods, Translational Research, Biomedical organization & administration, Translational Research, Biomedical standards, Translational Research, Biomedical trends
- Abstract
Advances in genomics and related fields promise a new era of personalized medicine in the cancer care continuum. Nevertheless, there are fundamental challenges in integrating genomic medicine into cancer practice. We explore how multilevel research can contribute to implementation of genomic medicine. We first review the rapidly developing scientific discoveries in this field and the paucity of current applications that are ready for implementation in clinical and public health programs. We then define a multidisciplinary translational research agenda for successful integration of genomic medicine into policy and practice and consider challenges for successful implementation. We illustrate the agenda using the example of Lynch syndrome testing in newly diagnosed cases of colorectal cancer and cascade testing in relatives. We synthesize existing information in a framework for future multilevel research for integrating genomic medicine into the cancer care continuum.
- Published
- 2012
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37. Introduction: Understanding and influencing multilevel factors across the cancer care continuum.
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Taplin SH, Anhang Price R, Edwards HM, Foster MK, Breslau ES, Chollette V, Prabhu Das I, Clauser SB, Fennell ML, and Zapka J
- Subjects
- Decision Making, Early Detection of Cancer, Evidence-Based Medicine, Health Services Accessibility standards, Health Services Accessibility trends, Humans, Interdisciplinary Communication, Palliative Care standards, Palliative Care trends, Patient Protection and Affordable Care Act, Patient Safety, Practice Patterns, Physicians' standards, Precision Medicine, Social Environment, Socioeconomic Factors, Terminal Care standards, Terminal Care trends, Treatment Outcome, United States, Combined Modality Therapy adverse effects, Combined Modality Therapy standards, Continuity of Patient Care standards, Continuity of Patient Care trends, Disease Management, Neoplasms diagnosis, Neoplasms therapy, Patient Care Team standards, Patient Care Team trends, Patient Participation trends, Patient-Centered Care standards, Patient-Centered Care trends, Quality of Health Care
- Abstract
Health care in the United States is notoriously expensive while often failing to deliver the care recommended in published guidelines. There is, therefore, a need to consider our approach to health-care delivery. Cancer care is a good example for consideration because it spans the continuum of health-care issues from primary prevention through long-term survival and end-of-life care. In this monograph, we emphasize that health-care delivery occurs in a multilevel system that includes organizations, teams, and individuals. To achieve health-care delivery consistent with the Institute of Medicine's six quality aims (safety, effectiveness, timeliness, efficiency, patient-centeredness, and equity), we must influence multiple levels of that multilevel system. The notion that multiple levels of contextual influence affect behaviors through interdependent interactions is a well-established ecological view. This view has been used to analyze health-care delivery and health disparities. However, experience considering multilevel interventions in health care is much less robust. This monograph includes 13 chapters relevant to expanding the foundation of research for multilevel interventions in health-care delivery. Subjects include clinical cases of multilevel thinking in health-care delivery, the state of knowledge regarding multilevel interventions, study design and measurement considerations, methods for combining interventions, time as a consideration in the evaluation of effects, measurement of effects, simulations, application of multilevel thinking to health-care systems and disparities, and implementation of the Affordable Care Act of 2010. Our goal is to outline an agenda to proceed with multilevel intervention research, not because it guarantees improvement in our current approach to health care, but because ignoring the complexity of the multilevel environment in which care occurs has not achieved the desired improvements in care quality outlined by the Institute of Medicine at the turn of the millennium.
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- 2012
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38. Multilevel intervention research: lessons learned and pathways forward.
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Clauser SB, Taplin SH, Foster MK, Fagan P, and Kaluzny AD
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- Delivery of Health Care organization & administration, Delivery of Health Care standards, Delivery of Health Care trends, Health Care Reform standards, Health Care Reform trends, Health Policy, Humans, Interdisciplinary Communication, Organizational Culture, Patient Care Team standards, Patient Care Team trends, Quality of Health Care standards, Quality of Health Care trends, Research Design, United States, Continuity of Patient Care organization & administration, Continuity of Patient Care standards, Continuity of Patient Care trends, Delivery of Health Care, Integrated organization & administration, Delivery of Health Care, Integrated standards, Delivery of Health Care, Integrated trends, Health Services Research methods, Health Services Research trends, Healthcare Disparities, Neoplasms diagnosis, Neoplasms therapy
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This summary reflects on this monograph regarding multilevel intervention (MLI) research to 1) assess its added value; 2) discuss what has been learned to date about its challenges in cancer care delivery; and 3) identify specific ways to improve its scientific soundness, feasibility, policy relevance, and research agenda. The 12 submitted chapters, and discussion of them at the March 2011 multilevel meeting, were reviewed and discussed among the authors to elicit key findings and results addressing the questions raised at the outset of this effort. MLI research is underrepresented as an explicit focus in the cancer literature but may improve implementation of studies of cancer care delivery if they assess contextual, organizational, and environmental factors important to understanding behavioral and/or system-level interventions. The field lacks a single unifying theory, although several psychological or biological theories are useful, and an ecological model helps conceptualize and communicate interventions. MLI research designs are often complex, involving nonlinear and nonhierarchical relationships that may not be optimally studied in randomized designs. Simulation modeling and pilot studies may be necessary to evaluate MLI interventions. Measurement and evaluation of team and organizational interventions are especially needed in cancer care, as are attention to the context of health-care reform, eHealth technology, and genomics-based medicine. Future progress in MLI research requires greater attention to developing and supporting relevant metrics of level effects and interactions and evaluating MLI interventions. MLI research holds an unrealized promise for understanding how to improve cancer care delivery.
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- 2012
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39. In search of synergy: strategies for combining interventions at multiple levels.
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Weiner BJ, Lewis MA, Clauser SB, and Stitzenberg KB
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- Effect Modifier, Epidemiologic, Humans, Negotiating, Social Environment, United States, Combined Modality Therapy standards, Continuity of Patient Care standards, Continuity of Patient Care trends, Delivery of Health Care, Integrated standards, Delivery of Health Care, Integrated trends, Models, Organizational, Neoplasms diagnosis, Neoplasms therapy, Patient Care Team standards, Patient Care Team trends, Quality of Health Care standards, Quality of Health Care trends
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The social ecological perspective provides a compelling justification for multilevel intervention. Yet, it offers little guidance for selecting interventions that work together in complementary or synergistic ways. Using a causal modeling framework, we describe five strategies for increasing potential complementarity or synergy among interventions that operate at different levels of influence: accumulation, amplification, facilitation, cascade, and convergence. We illustrate these strategies with examples of multilevel interventions to improve the quality of cancer treatment.
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- 2012
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40. Summary of the multilevel interventions in health care conference.
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Edwards HM, Taplin SH, Chollette V, Clauser SB, Prabhu Das I, and Kaluzny AD
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- Congresses as Topic, Delivery of Health Care organization & administration, Delivery of Health Care standards, Delivery of Health Care trends, Health Policy, Humans, Interdisciplinary Communication, Patient Care Team standards, Patient Care Team trends, Publishing standards, Quality of Health Care standards, Quality of Health Care trends, Research Design, United States, Continuity of Patient Care organization & administration, Continuity of Patient Care standards, Continuity of Patient Care trends, Delivery of Health Care, Integrated organization & administration, Delivery of Health Care, Integrated standards, Delivery of Health Care, Integrated trends, Health Services Research methods, Health Services Research trends, Healthcare Disparities, Neoplasms diagnosis, Neoplasms therapy
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- 2012
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41. Multilevel interventions: measurement and measures.
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Charns MP, Foster MK, Alligood EC, Benzer JK, Burgess JF Jr, Li D, McIntosh NM, Burness A, Partin MR, and Clauser SB
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- Cancer Care Facilities standards, Cancer Care Facilities statistics & numerical data, Confounding Factors, Epidemiologic, Delivery of Health Care, Integrated standards, Delivery of Health Care, Integrated trends, Humans, Neoplasms prevention & control, Outcome Assessment, Health Care, Patient Care Team standards, Patient Care Team trends, Quality of Health Care standards, Quality of Health Care trends, United States, Continuity of Patient Care standards, Continuity of Patient Care trends, Health Services Research methods, Health Services Research trends, Interdisciplinary Communication, Neoplasms diagnosis, Neoplasms therapy, Outcome and Process Assessment, Health Care, Research Design
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Background: Multilevel intervention research holds the promise of more accurately representing real-life situations and, thus, with proper research design and measurement approaches, facilitating effective and efficient resolution of health-care system challenges. However, taking a multilevel approach to cancer care interventions creates both measurement challenges and opportunities., Methods: One-thousand seventy two cancer care articles from 2005 to 2010 were reviewed to examine the state of measurement in the multilevel intervention cancer care literature. Ultimately, 234 multilevel articles, 40 involving cancer care interventions, were identified. Additionally, literature from health services, social psychology, and organizational behavior was reviewed to identify measures that might be useful in multilevel intervention research., Results: The vast majority of measures used in multilevel cancer intervention studies were individual level measures. Group-, organization-, and community-level measures were rarely used. Discussion of the independence, validity, and reliability of measures was scant., Discussion: Measurement issues may be especially complex when conducting multilevel intervention research. Measurement considerations that are associated with multilevel intervention research include those related to independence, reliability, validity, sample size, and power. Furthermore, multilevel intervention research requires identification of key constructs and measures by level and consideration of interactions within and across levels. Thus, multilevel intervention research benefits from thoughtful theory-driven planning and design, an interdisciplinary approach, and mixed methods measurement and analysis.
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- 2012
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42. Systems strategies to support cancer screening in U.S. primary care practice.
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Yabroff KR, Zapka J, Klabunde CN, Yuan G, Buckman DW, Haggstrom D, Clauser SB, Miller J, and Taplin SH
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- Adult, Early Detection of Cancer standards, Female, Guideline Adherence, Health Care Surveys, Humans, Male, Middle Aged, Physicians, Primary Care, Practice Patterns, Physicians', Primary Health Care standards, United States, Early Detection of Cancer methods, Primary Health Care organization & administration
- Abstract
Background: Although systems strategies are effective in improving health care delivery, little is known about their use for cancer screening in U.S. primary care practice., Methods: We assessed primary care physicians' (N = 2,475) use of systems strategies for breast, cervical, and colorectal cancer (CRC) screening in a national survey conducted in 2007. Systems strategies included patient and physician screening reminders, performance reports of screening rates, electronic medical records, implementation of in-practice guidelines, and use of nurse practitioners/physician assistants. We evaluated use of both patient and physician screening reminders with other strategies in separate models by screening type, adjusted for the effects of physician and practice characteristics with multivariate logistic regression., Results: Fewer than 10% of physicians used a comprehensive set of systems strategies to support cancer screening; use was greater for mammography and Pap testing than for CRC screening. In adjusted analyses, performance reports of cancer screening rates, medical record type, and in-practice guidelines were associated with use of both patient and physician screening reminders for mammography, Pap testing, and CRC screening (P < 0.05)., Conclusion: Despite evidence supporting use of systems strategies in primary care, few physicians report using a comprehensive set of strategies to support cancer screening., Impact: Current health policy initiatives underscore the importance of increased implementation of systems strategies in primary care to improve the use and quality of cancer screening in the United States.
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- 2011
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43. Population sciences, translational research, and the opportunities and challenges for genomics to reduce the burden of cancer in the 21st century.
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Khoury MJ, Clauser SB, Freedman AN, Gillanders EM, Glasgow RE, Klein WM, and Schully SD
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- Evidence-Based Medicine, History, 21st Century, Humans, Delivery of Health Care, Genetics, Population history, Genomics history, Preventive Medicine, Translational Research, Biomedical history
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Advances in genomics and related fields are promising tools for risk assessment, early detection, and targeted therapies across the entire cancer care continuum. In this commentary, we submit that this promise cannot be fulfilled without an enhanced translational genomics research agenda firmly rooted in the population sciences. Population sciences include multiple disciplines that are needed throughout the translational research continuum. For example, epidemiologic studies are needed not only to accelerate genomic discoveries and new biological insights into cancer etiology and pathogenesis, but to characterize and critically evaluate these discoveries in well-defined populations for their potential for cancer prediction, prevention and response to treatment. Behavioral, social, and communication sciences are needed to explore genomic-modulated responses to old and new behavioral interventions, adherence to therapies, decision making across the continuum, and effective use in health care. Implementation science, health services, outcomes research, comparative effectiveness research, and regulatory science are needed for moving validated genomic applications into practice and for measuring their effectiveness, cost-effectiveness, and unintended consequences. Knowledge synthesis, evidence reviews, and economic modeling of the effects of promising genomic applications will facilitate policy decisions and evidence-based recommendations. Several independent and multidisciplinary panels have recently made specific recommendations for enhanced research and policy infrastructure to inform clinical and population research for moving genomic innovations into the cancer care continuum. An enhanced translational genomics and population sciences agenda is urgently needed to fulfill the promise of genomics in reducing the burden of cancer., (©2011 AACR)
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- 2011
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44. Electronic toxicity monitoring and patient-reported outcomes.
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Basch EM, Reeve BB, Mitchell SA, Clauser SB, Minasian L, Sit L, Chilukuri R, Baumgartner P, Rogak L, Blauel E, Abernethy AP, and Bruner D
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- Antineoplastic Agents therapeutic use, Humans, Treatment Outcome, Antineoplastic Agents adverse effects, Computer Communication Networks, Drug Monitoring methods, Neoplasms drug therapy, Research Report, Software
- Abstract
Understanding the potential profile of adverse events associated with cancer treatment is essential in balancing safety versus benefits. Multiple stakeholders make use of this information for decision making, including patients, clinicians, researchers, regulators, and payors. Currently, adverse events are reported by clinical research staff, yet evidence suggests that this may contribute to underreporting of symptom events. Direct patient reporting via electronic interfaces offers a promising mechanism to enhance the efficiency and precision of our current approach and may complement clinician reports of adverse events. The National Cancer Institute has contracted to develop and test an item bank and software system for directly eliciting adverse symptom event information from patients in cancer clinical research, called the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events. The validity, usability, and scalability of the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events prototype are currently being examined in academic and community-based settings.
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- 2011
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45. Improving modern cancer care through information technology.
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Clauser SB, Wagner EH, Aiello Bowles EJ, Tuzzio L, and Greene SM
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- Communication, Cooperative Behavior, Humans, Patient Participation, Quality of Health Care, Medical Informatics organization & administration, Neoplasms therapy, Patient-Centered Care organization & administration
- Abstract
The cancer care system is increasingly complex, marked by multiple hand-offs between primary care and specialty providers, inadequate communication among providers, and lack of clarity about a "medical home" (the ideal accountable care provider) for cancer patients. Patients and families often cite such difficulties as information deficits, uncoordinated care, and insufficient psychosocial support. This article presents a review of the challenges of delivering well coordinated, patient-centered cancer care in a complex modern healthcare system. An examination is made of the potential role of information technology (IT) advances to help both providers and patients. Using the published literature as background, a review is provided of selected work that is underway to improve communication, coordination, and quality of care. Also discussed are additional challenges and opportunities to advancing understanding of how patient data, provider and patient involvement, and informatics innovations can support high-quality cancer care., (Copyright © 2011 American Journal of Preventive Medicine. All rights reserved.)
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- 2011
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46. Assessment of quality of cancer-related follow-up care from the cancer survivor's perspective.
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Arora NK, Reeve BB, Hays RD, Clauser SB, and Oakley-Girvan I
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- Aged, Attitude of Health Personnel, California, Colorectal Neoplasms mortality, Colorectal Neoplasms psychology, Communication, Cross-Sectional Studies, Female, Health Knowledge, Attitudes, Practice, Health Promotion, Humans, Leukemia psychology, Linear Models, Male, Middle Aged, Patient-Centered Care, Perception, Physician-Patient Relations, Registries, Surveys and Questionnaires, Time Factors, Urinary Bladder Neoplasms mortality, Urinary Bladder Neoplasms psychology, Colorectal Neoplasms therapy, Leukemia therapy, Patient Satisfaction, Quality of Health Care, Survivors psychology, Urinary Bladder Neoplasms therapy
- Abstract
Purpose: We assessed cancer survivors' perceptions of the quality of their follow-up care., Methods: We surveyed a population-based cohort of leukemia, bladder, and colorectal cancer survivors diagnosed 2 to 5 years previously in northern California (N = 623; participation rate, 69.2%; overall response rate, 49.2%). Data were collected between April 2003 and November 2004. Ten scales assessed survivors' perceptions of different aspects of care in the last 12 months, and an eleventh scale measured their overall ratings of care., Results: On nine of the 11 scales, mean scores ranged from 88 to 97 on a 0 to 100 response format, indicating very positive experiences. The two areas where quality perceptions were lower were discussions about health promotion and the physician's knowledge of the whole patient. In adjusted analyses, those without private health insurance (P = .02) and Hispanic and Asian survivors compared with whites (P < .001) reported worse timeliness of care. Survivors who had multiple comorbidities reported better scores on timeliness of care (P < .01) and physicians' knowledge (P = .05) than survivors without any comorbidity. Length of the patient-physician relationship was the variable most consistently found to be significantly associated with survivors' quality assessments. Physicians' information exchange had the strongest relationship with overall ratings of care, followed by physicians' affective behavior, their knowledge of the survivor, and survivors' perceptions of coordination of care (P < .001 for all)., Conclusion: Delivery of quality follow-up care to cancer survivors may require efforts to improve patient-centered communication and coordination. Special emphasis may need to be placed on health promotion discussions and adoption of a whole-person orientation.
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- 2011
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47. Stakeholder perspectives on implementing the National Cancer Institute's patient-reported outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE).
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Bruner DW, Hanisch LJ, Reeve BB, Trotti AM, Schrag D, Sit L, Mendoza TR, Minasian L, O'Mara A, Denicoff AM, Rowland JH, Montello M, Geoghegan C, Abernethy AP, Clauser SB, Castro K, Mitchell SA, Burke L, Trentacosti AM, and Basch EM
- Abstract
The National Cancer Institute (NCI) is developing a patient-reported version of its Common Terminology Criteria for Adverse Events, called the "PRO-CTCAE." The PRO-CTCAE consists of a library of patient-reported items which can be administered in clinical trials to directly capture the patient experience of adverse events during cancer treatment, as well as a software platform for administering these items via computer or telephone. In order to better understand the impressions of stakeholders involved in cancer clinical research about the potential value of the PRO-CTCAE approach to capturing adverse event information in clinical research, as well as their perspectives about barriers and strategies for implementing the PRO-CTCAE in NCI-sponsored cancer trials, a survey was conducted. A survey including structured and open-ended questions was developed to elicit perceptions about the use of patient-reported outcomes (PROs) for adverse event reporting, and to explore logistical considerations for implementing the PRO-CTCAE in cancer trials. The survey was distributed electronically and by paper to a convenience sample of leadership and committee members in the NCI's cooperative group network, including principal investigators, clinical investigators, research nurses, data managers, patient advocates, and representatives of the NCI and Food and Drug Administration. Between October, 2008 through February, 2009, 727 surveys were collected. Most respondents (93%) agreed that patient reporting of adverse symptoms would be useful for improving understanding of the patient experience with treatment in cancer trials, and 88%, 80%, and 76%, respectively, endorsed that administration of PRO-CTCAE items in clinical trials would improve the completeness, accuracy, and efficiency of symptom data collection. More than three fourths believed that patient reports would be useful for informing treatment dose modifications and towards FDA regulatory evaluation of drugs. Eighty-eight percent felt that patients in clinical trials would be willing to self-report adverse symptoms at clinic visits via computer, and 68% felt patients would self-report weekly from home via the internet or an automated telephone system. Lack of computers and limited space and personnel were seen as potential barriers to in-clinic self-reporting, but these were judged to be surmountable with adequate funding. The PRO-CTCAE items and software are viewed by a majority of survey respondents as a means to improve adverse event data quality and comprehensiveness, enhance clinical decision-making, and foster patient-clinician communication. Research is ongoing to assess the measurement properties and feasibility of implementing this measure in cancer clinical trials.
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- 2011
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48. The quality of cancer patient experience: perspectives of patients, family members, providers and experts.
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Wagner EH, Aiello Bowles EJ, Greene SM, Tuzzio L, Wiese CJ, Kirlin B, and Clauser SB
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- Focus Groups, Humans, United States, Family psychology, Health Personnel psychology, Neoplasms therapy, Patient Satisfaction, Quality of Health Care
- Abstract
Background: Anecdotes and limited evidence suggest that a significant percentage of cancer patients encounter troublesome problems in the course of their care., Methods: The authors collected data about barriers to and facilitators of high-quality cancer care and innovative solutions to improve quality from three sources: focus groups with patients, family members of cancer patients and providers; site visits to cancer care providers and organisations in three American communities; and expert interviews., Results: The authors' respondents consistently described a similar list of problems facing the individual with a suspicion or diagnosis of cancer and his/her family: delays in and lack of coordination of care, patient information gaps and passivity, inadequate attention to emotional and social problems, and difficulty accessing services because of inadequate insurance, limited financial resources or rural residence. The fragmentation and uncertain accountability of cancer care contribute to these issues. Respondents recommended linking patients with a care navigator or manager, using computer technology to better inform and support patients and connect providers, and reforming provider reimbursement to encourage more patient-centred care., Conclusions: Cancer patients and their families have urgent needs for information and support especially early in their course. To meet these needs, early cancer care must be better organised, integrated, and patient centred. The Institute of Medicine's Model for the Delivery of Psychosocial Services appears to provide a relevant guide to delivering cancer care that better meets patient and family needs.
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- 2010
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49. The health disparities cancer collaborative: a case study of practice registry measurement in a quality improvement collaborative.
- Author
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Haggstrom DA, Clauser SB, and Taplin SH
- Abstract
Background: Practice registry measurement provides a foundation for quality improvement, but experiences in practice are not widely reported. One setting where practice registry measurement has been implemented is the Health Resources and Services Administration's Health Disparities Cancer Collaborative (HDCC)., Methods: Using practice registry data from 16 community health centers participating in the HDCC, we determined the completeness of data for screening, follow-up, and treatment measures. We determined the size of the change in cancer care processes that an aggregation of practices has adequate power to detect. We modeled different ways of presenting before/after changes in cancer screening, including count and proportion data at both the individual health center and aggregate collaborative level., Results: All participating health centers reported data for cancer screening, but less than a third reported data regarding timely follow-up. For individual cancers, the aggregate HDCC had adequate power to detect a 2 to 3% change in cancer screening, but only had the power to detect a change of 40% or more in the initiation of treatment. Almost every health center (98%) improved cancer screening based upon count data, while fewer (77%) improved cancer screening based upon proportion data. The aggregate collaborative appeared to increase breast, cervical, and colorectal cancer screening rates by 12%, 15%, and 4%, respectively (p < 0.001 for all before/after comparisons). In subgroup analyses, significant changes were detectable among individual health centers less than one-half of the time because of small numbers of events., Conclusions: The aggregate HDCC registries had both adequate reporting rates and power to detect significant changes in cancer screening, but not follow-up care. Different measures provided different answers about improvements in cancer screening; more definitive evaluation would require validation of the registries. Limits to the implementation and interpretation of practice registry measurement in the HDCC highlight challenges and opportunities for local and aggregate quality improvement activities.
- Published
- 2010
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50. National Collaborative to Improve Oncology Practice: The National Cancer Institute Community Cancer Centers Program Quality Oncology Practice Initiative Experience.
- Author
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Siegel RD, Clauser SB, and Lynn JM
- Abstract
Collaboration between QOPI and the NCCCP sites represents an evolution in the QOPI process, in which QOPI provides a metric for measuring quality and serves as a springboard for comprehensive quality improvement across independent but mutually committed practices.
- Published
- 2009
- Full Text
- View/download PDF
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