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50 results on '"Clemente, Maria Grazia"'

1. Diagnostic approach to neonatal and infantile cholestasis: A position paper by the SIGENP liver disease working group

Author

Ranucci, Giusy, Della Corte, Claudia, Alberti, Daniele, Bondioni, Maria Pia, Boroni, Giovanni, Calvo, Pier Luigi, Cananzi, Mara, Candusso, Manila, Clemente, Maria Grazia, D'Antiga, Lorenzo, Degrassi, Irene, De Ville De Goyet, Jean, Di Dato, Fabiola, Di Giorgio, Angelo, Vici, Carlo Dionisi, Ferrari, Federica, Francalanci, Paola, Fuoti, Maurizio, Fusaro, Fabio, Gaio, Paola, Grimaldi, Chiara, Iascone, Maria, Indolfi, Giuseppe, Iorio, Raffaele, Maggiore, Giuseppe, Mandato, Claudia, Matarazzo, Lorenza, Monti, Lidia, Mosca, Fabio, Nebbia, Gabriella, Nuti, Federica, Paolella, Giulia, Pinon, Michele, Roggero, Paola, Sciveres, Marco, Serranti, Daniele, Spada, Marco, Vajro, Pietro, and Nicastro, Emanuele

Published
2022
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3. Vitamin D Status in an Italian Pediatric Cohort: Is There a Role for Tobacco Smoking Exposure?

Author

Clemente, Maria Grazia, Argiolas, Dario, Bassu, Stefania, Bitti, Angela, Locci, Cristian, Argiolas, Mauro, Argiolas, Lino, Saderi, Laura, Puci, Mariangela V., Sotgiu, Giovanni, Blue, Mary E., and Antonucci, Roberto

Subjects
*VITAMIN D deficiency, *RISK assessment, *DESCRIPTIVE statistics, *LUMINESCENCE spectroscopy, *ENVIRONMENTAL exposure, *IMMUNOASSAY, *VITAMIN D, *PASSIVE smoking, *DISEASE risk factors, *CHILDREN
Abstract

Objective: Vitamin D deficiency is a common public health issue worldwide. The purpose of this study was to investigate the vitamin D status and its potential determinants in children residing in Sardinia (40°N), Italy. Methods: Children were enrolled over a 12-month period. Serum 25(OH)D was measured by an immunochemiluminescence assay. A questionnaire was used to gather information on other variables, including passive smoke exposure. Results: A total of 182 children (males: 51.7%; median age: 9 years) were included. Mean±standard deviation serum 25(OH)D was 25.2±8.3 ng/mL for the whole group. The majority (n=123, 67.6%) had vitamin D sufficient values >20 ng/mL, while 32.4% (n=59) had vitamin D insufficient/deficient values (≤20 ng/mL). Among the variables investigated, passive smoke exposure was significantly associated with insufficient 25(OH)D levels (p<0.0001). Conclusion: Our results confirm that hypovitaminosis D is common in Italian children. Furthermore, passive smoke exposure was identified as a significant risk factor for hypovitaminosis D. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Deferasirox film‐coated tablet‐associated ulcerative colitis: An emerging pattern in thalassemia patients?

Author

Piolatto, Andrea, primary, Gaglioti, Carmen Maria, additional, Tesio, Nicolò, additional, Clemente, Maria Grazia, additional, Culcasi, Martina, additional, Matrone, Alessio, additional, Pila, Maria Paola, additional, Sambataro, Angela, additional, Longo, Filomena, additional, Origa, Raffaella, additional, and Ferrero, Giovanni Battista, additional

Published
2024
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8. Safety and Efficacy of the New Combination Iron Chelation Regimens in Patients with Transfusion-Dependent Thalassemia and Severe Iron Overload

Author

Origa, Raffaella, primary, Cinus, Monia, additional, Pilia, Maria Paola, additional, Gianesin, Barbara, additional, Zappu, Antonietta, additional, Orecchia, Valeria, additional, Clemente, Maria Grazia, additional, Pitturru, Carla, additional, Denotti, Anna Rita, additional, Corongiu, Francesco, additional, Piras, Simona, additional, and Barella, Susanna, additional

Published
2022
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12. No Hepatitis G virus co-infection in migrants with Hepatitis B or C hosted in Sardinia and Sicily

Author

Clemente, Maria Grazia, primary, Mauceri, Carlo, additional, Grandi, Nicola, additional, Marescalco, Salvatore, additional, Arras, Margherita, additional, Bitti, Angela, additional, Galleri, Grazia, additional, Manetti, Roberto, additional, Schwarz, Kathleen, additional, Piana, Andrea, additional, Castiglia, Paolo, additional, and Antonucci, Roberto, additional

Published
2020
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14. VAPB ER-Aggregates, A Possible New Biomarker in ALS Pathology

Author

Cadoni, Maria Piera L, primary, Biggio, Maria Luigia, additional, Arru, Giannina, additional, Secchi, Giannina, additional, Orrù, Nicola, additional, Clemente, Maria Grazia, additional, Sechi, GianPietro, additional, Yamoah, Alfred, additional, Tripathi, Priyanka, additional, Orrù, Sandro, additional, Manetti, Roberto, additional, and Galleri, Grazia, additional

Published
2020
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16. Family‐related factors may affect serum vitamin D levels

Author

Clemente, Maria Grazia, primary, Argiolas, Dario, additional, Blue, Mary E., additional, Argiolas, Lino, additional, Bitti, Angela, additional, Saderi, Laura, additional, Piana, Andrea, additional, Sotgiu, Giovanni, additional, and Antonucci, Roberto, additional

Published
2019
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19. Intrahepatic bile duct primary cilia in biliary atresia

Author

Frassetto, Roberta, Parolini, Filippo, Marceddu, Salvatore, Satta, Giulia, Papacciuoli, Valeria, Pinna, Maria Antonia, Mela, Alessandra, Secchi, Giannina, Galleri, Grazia, Manetti, Roberto, Bercich, Luisa, Villanacci, Vincenzo, Dessanti, Antonio, Antonucci, Roberto, Tanda, Francesco, Alberti, Daniele, Schwarz, Kathleen B., and Clemente, Maria Grazia

Subjects
Biliary disease, Liver transplantation, Choledochal cyst, Liver fibrosis, Scanning electron microscopy
Abstract

Aim: The etiopathogenesis of non-syndromic biliary atresia (BA) is obscure. The primary aim was to investigate intrahepatic bile duct cilia (IHBC) in BA at diagnosis and its correlation with clinical outcome. The secondary aim was to analyze IHBC in routine paraffin-embedded liver biopsies using conventional scanning electron microscopy (SEM). Methods: Surgical liver biopsies taken at diagnosis from 22 BA infants (age range, 39-116 days) and from eight children with non-BA chronic cholestasis (age range, 162 days -16.8 years) were evaluated for IHBC by immunofluorescence (IF) and SEM. A minimum 18-month follow-up after surgery was available for all patients. Results: By IF, cilia were present in 6/8 (75%) non-BA but only in 3/22 (14%) BA cases, and cilia were reduced or absent in 19/22 (86%) BA and 2/8 (25%) non-BA livers (P90% at 12 months, and >70% at 24 months post-surgery, were recorded regardless of cilia presence/absence at diagnosis. Electron microscopy was able to detect bile ducts and cilia in routine liver biopsies, revealing significant abnormalities in 100% BA livers. Conclusions: The presence of IHBC in BA livers at the diagnosis was associated with resolution of cholestasis, although was not predictive of short-term survival with native liver. Scanning electron microscopy represents a powerful new tool to study routine liver biopsies in biliary disorders. Cilia dysfunction in BA pathogenesis and/or disease progression warrants further investigation.

Published
2018
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20. Pediatric tuberculosis in Northern Sardinia

Author

Clemente, Maria Grazia, Dore, Elena, Abis, Lidia, Molicotti, Paola, Zanetti, Stefania, Olmeo, Paolina, and Antonucci, Roberto

Subjects
tuberculosis household contacts, active tuberculosis, latent tuberculosis, MED/38 Pediatria generale e specialistica, Original Article, multi-drug resistant tuberculosis, MED/07 Microbiologia e microbiologia clinica
Abstract

Background and objectives: Migration flux is an increasing phenomenon in Italy, and it raises several public health issues and concerns in pediatric infectious diseases. This study investigated the clinical characteristics and outcomes of a pediatric population at high-risk for tuberculosis (TB) and the potential role of immigration as a risk factor. Design: We performed an observational retrospective study of children referred to the only Pediatric Infectious Diseases Unit for Northern Sardinia over a 6-year-period (2009-2014). Main variables assessed included TB skin test (TST), confirmed by quantiFERON Gold in Tube test, thorax X-ray (TX), microbiological culture, direct microscopy for acid-fast bacilli and molecular assays. Results: Of the 246 children (mean age = 5.8 ± 3.9 years) identified, 222 (90.2%) were native to Sardinia and 24 (9.8%) were immigrants. The majority of children (n=205; 83%) were TB-exposed but not infected based on a negative TST and TX. Among the TST positive group (n= 39; 16%), 19 (49%) had latent TB (TX negative), while 20 (51%) had active TB (TX positive). The percent of TST positive children was significantly higher in the immigrant than the native group (42.5% versus 14%, p Conclusions: Pediatric TB represents a relevant and potentially worsening public health problem in Northern Sardinia. A strict surveillance system and appropriate treatment can prevent the most severe forms and reduce TB transmission.

Published
2017

21. AISF position paper on HCV in immunocompromised patients

Author

Marzano, Alfredo, primary, Angelucci, Emanuele, additional, Astegiano, Marco, additional, Baratelli, Chiara, additional, Biancone, Luigi, additional, Bironzo, Paolo, additional, Brancaccio, Giuseppina, additional, Brunetto, Maurizia Rossana, additional, Bruno, Raffaele, additional, Burra, Patrizia, additional, Cabras, Maria Giuseppina, additional, Caraceni, Paolo, additional, Chialà, Claudia, additional, Clemente, Maria Grazia, additional, Colli, Agostino, additional, Daniele, Bruno, additional, De Gasperi, Elisabetta, additional, Di Marco, Vito, additional, Ditto, Maria Chiara, additional, Fagiuoli, Stefano, additional, Ferri, Clodoveo, additional, Gaeta, Giovanni Battista, additional, Grossi, Paolo Antonio, additional, Imperatrice, Barbara, additional, Lampertico, Pietro, additional, Macaluso, Fabio Salvatore, additional, Madonia, Salvatore, additional, Marignani, Massimo, additional, Mazzarelli, Chiara, additional, Mella, Alberto, additional, Missale, Gabriele, additional, Parisi, Simone, additional, Pasulo, Luisa, additional, Puoti, Massimo, additional, Rendina, Maria, additional, Ribaldone, Davide, additional, Rossi, Giuseppe, additional, Toniutto, Pierluigi, additional, Tucci, Alessandra, additional, Vajro, Pietro, additional, Viganò, Mauro, additional, Volpes, Riccardo, additional, and Zignego, Anna Linda, additional

Published
2019
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22. Ceftriaxone‐associated biliary pseudolithiasis in children: do we know enough?

Author

Cuzzolin, Laura, Oggiano, Anna Maria, Clemente, Maria Grazia, Locci, Cristian, Antonucci, Luca, and Antonucci, Roberto

Subjects
CHILD patients, CHOLANGITIS, CEFTRIAXONE, GALLSTONES, DRUG prescribing, BACTERIAL diseases, HOSPITAL housekeeping
Abstract

Ceftriaxone is an antibiotic agent frequently used in paediatric hospital practice for the treatment of severe bacterial infections. The use of this agent can result in cholelithiasis and/or biliary sludge, more commonly in children than in adults. This systematic review was aimed at analysing available literature concerning ceftriaxone‐associated biliary pseudolithiasis in paediatric patients, with a special emphasis on the clinical aspects. A literature analysis was performed using Medline and Embase electronic databases (articles published in English up to December 2019), with the search terms and combinations as follows:'ceftriaxone', 'cholelithiasis', 'biliary sludge' 'gallstones' 'neonates' 'children' 'clinical aspects' 'management'. Several case reports, case series and prospective/retrospective studies have documented a relationship between ceftriaxone treatment and biliary pseudolithiasis in the paediatric population, even though literature data regarding neonates and infants are scarce. Ceftriaxone‐associated biliary pseudolithiasis is dose‐dependent and usually asymptomatic but, sometimes, it may present with abdominal pain, nausea and emesis. Abdominal ultrasonography should be performed when this complication is suspected. Generally, ceftriaxone‐associated cholelithiasis resolves over a variable period of time (days to months) after cessation of therapy. Therefore, a conservative approach to this condition is advocated, but a prolonged follow‐up may be necessary. A personalized assessment of factors predisposing to ceftriaxone‐associated biliary pseudolithiasis before prescribing the drug can allow to minimize the risk of developing it, with significant advantages in terms of human and economic costs. [ABSTRACT FROM AUTHOR]

Published
2021
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24. Autoantibodies against CYP-2C19: a novel serum marker in pediatric de-novo autoimmune hepatitis?

Author

Clemente, Maria Grazia, Antonucci, Roberto, Mandato, Claudia, Cicotto, Lucia, Meloni, Antonella, Gridelli, Bruno, De Virgiliis, Stefano, Manns, Michael P., and Vajro, Pietro

Subjects
MED/38 Pediatria generale e specialistica
Abstract

Diagnosis of de-novo autoimmune hepatitis (AIH) after orthotopic liver transplantation (OLT) is challenging especially in absence of hyper--globulinemia. Circulating autoantibodies are not sensitive nor specific in de-novo AIH, but when positive increase the diagnostic probability. We report the discovery of novel liver microsomal (LM) autoantibodies against CYP-2C19 in a 9-year-old boy with “de novo” AIH developed 7 years after OLT. Graft dysfunction presented with hypertransaminasemia (up to 400 IU/L), while serum γ-globulins remained within the normal range for age. Liver histology and response to high dose prednisone (2mg/kg/day) with the addition of azathioprine therapy further supported the diagnosis of de-novo AIH. Autoantibodies investigation by indirect immunofluorescence (IF) on rodent tissues showed a novel staining pattern involving the pericentral liver zone and sparing the renal tissue. Human but not rat liver proteins immunoblottings allowed us to characterize the novel LM antibodies and to identify CYP-2C19 as human antigen. The finding offers insights into the controversial discussion about autoimmunity versus alloreactivity with regard to the pathogenesis of de-novo AIH. Correct information on human versus rat tissue antigens tested by methods other than IF for antibodies detection may have significant implications for the correct diagnosis and management of patients followed up after OLT.

Published
2017

25. Intrahepatic bile duct primary cilia in biliary atresia

Author

Frassetto, Roberta, primary, Parolini, Filippo, additional, Marceddu, Salvatore, additional, Satta, Giulia, additional, Papacciuoli, Valeria, additional, Pinna, Maria Antonia, additional, Mela, Alessandra, additional, Secchi, Giannina, additional, Galleri, Grazia, additional, Manetti, Roberto, additional, Bercich, Luisa, additional, Villanacci, Vincenzo, additional, Dessanti, Antonio, additional, Antonucci, Roberto, additional, Tanda, Francesco, additional, Alberti, Daniele, additional, Schwarz, Kathleen B., additional, and Clemente, Maria Grazia, additional

Published
2018
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28. PEDIATRIC TUBERCULOSIS IN THE NORTH SARDINIA

Author

Clemente, Maria Grazia, primary, Dore, Elena, additional, Abis, Lidia, additional, Molicotti, Paola, additional, Zanetti, Stefania, additional, Olmeo, Paolina, additional, and Antonucci, Roberto, additional

Published
2017
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39. EARLY EFFECTS OF GLIADIN ON HUMAN INTESTINAL MUCOSA AND INTESTINAL CELL LINES

Author

Clemente, Maria Grazia, primary, Drago, Sandro, additional, Asmar, Ramzi El, additional, Pierro, Maria Rosaria Di, additional, Sapone, Anna, additional, Thakar, Manjiusha, additional, Iacono, Giuseppe, additional, Carroccio, Antonio, additional, D??Agate, Cinzia, additional, Not, Tarcisio, additional, Zampini, Lucia, additional, Catassi, Carlo, additional, and Fasano, Alessio, additional

Published
2005
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40. ZONULIN, AN INTESTINAL TIGHT JUNCTION MODULATOR, IS INVOLVED IN THE PATHOGENESIS OF TYPE I DIABETES

Author

Sapone, Anna, primary, de Magistris, Laura, additional, Iafusco, Dario, additional, Prisco, Franco, additional, Carratuʼ, Romano, additional, Bizzarri, Barbara, additional, Clemente, Maria Grazia, additional, Musu, Maria Paola, additional, Lampis, Rosanna, additional, Cucca, Francesco, additional, Piredda, Gavina, additional, Counts, Debra, additional, and Fasano, Alessio, additional

Published
2003
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47. AISF position paper on HCV in immunocompromised patients

Author

Gabriele Missale, Mauro Viganò, Marco Astegiano, Mauro Salizzoni, C. Chialà, Angelo Pera, Patrizia Racca, Massimo Di Maio, Mario Salomone, M. Puoti, Simone Parisi, Paolo Bironzo, M. Rendina, Carla Pasquina, Clodoveo Ferri, Luisa Pasulo, Rita Tozzi, A. Tucci, Pietro Lampertico, Emanuele Angelucci, Bruno Daniele, Patrizia Burra, Franco Riccardini, Marco Lagget, Fabio Salvatore Macaluso, Davide Giuseppe Ribaldone, Luca Miele, Clara Lisa Peroni, Raffaele Bruno, Anna Linda Zignego, Ambrogio Orlando, Giovanni Battista Gaeta, Giuseppe Montrucchio, Daniela Libertucci, Massimo Marignani, Agostino Colli, Enrico Fusaro, Antonio Craxì, Giorgio Maria Saracco, Barbara Imperatrice, Paolo Caraceni, Luisa Giaccone, Chiara Baratelli, Giuliano Torre, Luigi Biancone, Elisabetta De Gasperi, Mario Rizzetto, Maria Grazia Clemente, Francesco Paolo Russo, Aldo Giacardi, Riccardo Volpes, Edoardo G. Giannini, Daniele Curci, Rossella Della Valle, Salvatore Petta, Pierluigi Toniutto, Alessandro Busca, Pietro Vajro, Giorgio Verme, Chiara Mazzarelli, Paolo Grossi, Maria Chiara Ditto, Lorella Orsucci, Umberto Vitolo, Alberto Mella, Salvatore Madonia, Federica Cavallo, Maria Giuseppina Cabras, Stefano Bonora, Massimiliano Conforti, Vito Di Marco, Mario Pirisi, Giuseppe Cariti, Marta Coscia, Giuseppina Brancaccio, L. Scaglione, Stefano Fagiuoli, Alfredo Marzano, Stefano Cusinato, Roberto Minutolo, Giuseppe Rossi, Enrico Brignardello, Maurizia Rossana Brunetto, Marzano A., Angelucci E., Astegiano M., Baratelli C., Biancone L., Bironzo P., Brancaccio G., Brunetto M.R., Bruno R., Burra P., Cabras M.G., Caraceni P., Chiala C., Clemente M.G., Colli A., Daniele B., De Gasperi E., Di Marco V., Ditto M.C., Fagiuoli S., Ferri C., Gaeta G.B., Grossi P.A., Imperatrice B., Lampertico P., Macaluso F.S., Madonia S., Marignani M., Mazzarelli C., Mella A., Missale G., Parisi S., Pasulo L., Puoti M., Rendina M., Ribaldone D., Rossi G., Toniutto P., Tucci A., Vajro P., Vigano M., Volpes R., Zignego A.L., Giannini E.G., Miele L., Russo F.P., Petta S., Bonora S., Brignardello E., Busca A., Cariti G., Cavallo F., Conforti M., Coscia M., Craxi A., Curci D., Cusinato S., Di Maio M., Valle R.D., Fusaro E., Giacardi A., Giaccone L., Lagget M., Libertucci D., Minutolo R., Montrucchio G., Orlando A., Orsucci L., Pasquina C., Pera A., Peroni C.L., Pirisi M., Racca P., Riccardini F., Rizzetto M., Salizzoni M., Salomone M., Saracco G.M., Scaglione L., Torre G., Tozzi R., Vitolo U., Verme G., Angelucci, E, Astegiano, M, Baratelli, C, Biancone, L, Bironzo, P, Brancaccio, G, Brunetto, M, Bruno, R, Burra, P, Cabras, M, l Caraceni, P, Chialà, C, Clemente, M, Colli, A, Daniele, B, De Gasperi, E, Di Marco, V, Ditto, M, Fagiuoli, S, Ferri, C, Gaeta, G, Grossi, P, Imperatrice, B, Lampertico, P, Macaluso, F, Madonia, S, Marignani, M, Mazzarelli, C, Mella, A, Missale, G, Parisi, S, Pasulo, L, Puoti, M, Rendina, M, Ribaldone, D, Rossi, G, Toniutto, P, Tucci, A, Vajro, P, Viganò, M, Volpes, R, Zignego, A, Giannini, E, Miele, L, Russo, F, Petta, S, Bonora, S, Brignardello, E, Busca, A, Cariti, G, Cavallo, F, Conforti, M, Coscia, M, Craxì, A, Curci, D, Cusinato, S, Di Maio, M, Valle, R, Fusaro, E, Giacardi, A, Giaccone, L, Lagget, M, Libertucci, D, Minutolo, R, Montrucchio, G, Orlando, A, Orsucci, L, Pasquina, C, Pera, A, Peroni, C, Pirisi, M, Racca, P, Riccardini, F, Rizzetto, M, Salizzoni, M, Salomone, M, Saracco, G, Scaglione, L, Torre, G, Tozzi, R, Vitolo, U, Verme, G, Marzano, Alfredo, Angelucci, Emanuele, Astegiano, Marco, Baratelli, Chiara, Biancone, Luigi, Bironzo, Paolo, Brancaccio, Giuseppina, Brunetto, Maurizia Rossana, Bruno, Raffaele, Burra, Patrizia, Cabras, Maria Giuseppina, Caraceni, Paolo, Chialà, Claudia, Clemente, Maria Grazia, Colli, Agostino, Daniele, Bruno, De Gasperi, Elisabetta, Di Marco, Vito, Ditto, Maria Chiara, Fagiuoli, Stefano, Ferri, Clodoveo, Gaeta, Giovanni Battista, Grossi, Paolo Antonio, Imperatrice, Barbara, Lampertico, Pietro, Macaluso, Fabio Salvatore, Madonia, Salvatore, Marignani, Massimo, Mazzarelli, Chiara, Mella, Alberto, Missale, Gabriele, Parisi, Simone, Pasulo, Luisa, Puoti, Massimo, Rendina, Maria, Ribaldone, Davide, Rossi, Giuseppe, Toniutto, Pierluigi, Tucci, Alessandra, Vajro, Pietro, Viganò, Mauro, Volpes, Riccardo, Zignego, Anna Linda, Giannini, Edoardo G., Miele, Luca, Russo, Francesco Paolo, Petta, Salvatore, Bonora, Stefano, Brignardello, Enrico, Busca, Alessandro, Cariti, Giuseppe, Cavallo, Federica, Conforti, Massimiliano, Coscia, Marta, Craxì, Antonio, Curci, Daniele, Cusinato, Stefano, Di Maio, Massimo, Valle, Rossella Della, Fusaro, Enrico, Giacardi, Aldo, Giaccone, Luisa, Lagget, Marco, Libertucci, Daniela, Minutolo, Roberto, Montrucchio, Giuseppe, Orlando, Ambrogio, Orsucci, Lorella, Pasquina, Carla, Pera, Angelo, Peroni, Clara Lisa, Pirisi, Mario, Racca, Patrizia, Riccardini, Franco, Rizzetto, Mario, Salizzoni, Mauro, Salomone, Mario, Saracco, Giorgio Maria, Scaglione, Luca, Torre, Giuliano, Tozzi, Rita, Vitolo, Umberto, Verme, Giorgio, and Ditto, MARIA CHIARA

Subjects
medicine.medical_specialty, Transplant Recipient, Comorbidity, Antiviral Agents, Organ transplantation, 03 medical and health sciences, Immunocompromised Host, 0302 clinical medicine, Internal medicine, Neoplasms, medicine, Immunocompromised patient, Humans, Chronic, Intensive care medicine, Antiviral Agent, Hepatology, business.industry, Gastroenterology, Hepatitis C, Chronic, medicine.disease, Hepatitis C, Organ transplant, HCV, Immunocompromised patients, Transplant Recipients, Immunocompetence, Italy, 030220 oncology & carcinogenesis, HCV, Immunocompromised patients, Organ transplant, Position paper, Neoplasm, 030211 gastroenterology & hepatology, business, Direct acting, Human
Abstract

This report summarizes the clinical features and the indications for treating HCV infection in immunocompromised and transplanted patients in the Direct Acting Antiviral drugs era.

Published
2018

49. Pediatric Tuberculosis in Northern Sardinia.

Author

Clemente MG, Dore E, Abis L, Molicotti P, Zanetti S, Olmeo P, and Antonucci R

Abstract

Background and Objectives: Migration flux is an increasing phenomenon in Italy, and it raises several public health issues and concerns in pediatric infectious diseases. This study investigated the clinical characteristics and outcomes of a pediatric population at high-risk for tuberculosis (TB) and the potential role of immigration as a risk factor., Design: We performed an observational retrospective study of children referred to the only Pediatric Infectious Diseases Unit for Northern Sardinia over a 6-year-period (2009-2014). Main variables assessed included TB skin test (TST), confirmed by quantiFERON Gold in Tube test, thorax X-ray (TX), microbiological culture, direct microscopy for acid-fast bacilli and molecular assays., Results: Of the 246 children (mean age = 5.8 ± 3.9 years) identified, 222 (90.2%) were native to Sardinia and 24 (9.8%) were immigrants. The majority of children (n=205; 83%) were TB-exposed but not infected based on a negative TST and TX. Among the TST positive group (n= 39; 16%), 19 (49%) had latent TB (TX negative), while 20 (51%) had active TB (TX positive). The percent of TST positive children was significantly higher in the immigrant than the native group (42.5% versus 14%, p<0.001). Clinical presentations included pulmonary involvement with hilar lymphadenopathy (72%), pleurisy (13,5%), lateral-cervical lymphadenopathy (9%), pneumonia with calcifications (4.5%) and disseminated TB (4.5%). One child had multidrug-resistant tuberculosis., Conclusions: Pediatric TB represents a relevant and potentially worsening public health problem in Northern Sardinia. A strict surveillance system and appropriate treatment can prevent the most severe forms and reduce TB transmission., Competing Interests: Competing interests: The authors have declared that no competing interests exist.

Published
2017
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50. Hepatitis: general principles.

Author

Clemente MG and Schwarz K

Subjects
Child, Cholestasis diagnosis, Cholestasis etiology, Hepatic Encephalopathy diagnosis, Hepatic Encephalopathy etiology, Humans, Liver Cirrhosis diagnosis, Liver Cirrhosis etiology, Liver Failure diagnosis, Liver Failure etiology, Malnutrition diagnosis, Malnutrition etiology, Pruritus etiology, Hepatitis diagnosis, Hepatitis etiology, Hepatitis therapy
Abstract

After completing this article, readers should be able to: 1. Describe the procedure and interpretation of the laboratory evaluation of hepatitis. 2. Recognize the signs and symptoms of acute and chronic hepatitis.3. Describe the immediate and long-term complications of hepatitis. 4. List the multiple causes of hepatitis in an older child.

Published
2011
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