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1. Polarization Purity and Dispersion Characteristics of Nested Antiresonant Nodeless Hollow-Core Optical Fiber at Near- and Mid-IR Wavelengths for Quantum Communications

Author

Afxenti, Ivi, Yu, Lijun, Shields, Taylor, Faccio, Daniele, Bradley, Thomas, Caspani, Lucia, Clerici, Matteo, and Dada, Adetunmise C.

Subjects
Physics - Optics, Quantum Physics
Abstract

Advancements in quantum communication and sensing require improved optical transmission that ensures excellent state purity and reduced losses. While free-space optical communication is often preferred, its use becomes challenging over long distances due to beam divergence, atmospheric absorption, scattering, and turbulence, among other factors. In the case of polarization encoding, traditional silica-core optical fibers, though commonly used, struggle with maintaining state purity due to stress-induced birefringence. Hollow core fibers, and in particular nested antiresonant fibers (NANF), have recently been shown to possess unparalleled polarization purity with minimal birefringence in the telecom wavelength range using continuous-wave (CW) laser light. Here, we investigate a 1-km NANF designed for wavelengths up to the 2-{\mu}m waveband. Our results show a polarization extinction ratio between ~-30 dB and ~-70 dB across the 1520 to 1620 nm range in CW operation, peaking at ~-60 dB at the 2-{\mu}m design wavelength. Our study also includes the pulsed regime, providing insights beyond previous CW studies, e.g., on the propagation of broadband quantum states of light in NANF at 2 {\mu}m, and corresponding extinction-ratio-limited quantum bit-error rates (QBER) for prepare-measure and entanglement-based quantum key distribution (QKD) protocols. Our findings highlight the potential of these fibers in emerging applications such as QKD, pointing towards a new standard in optical quantum technologies.

Published
2024

2. Massive Compact Quiescent Galaxies in the $M_\star$ vs. $\sigma_\mathrm{e}$ Plane: Insights from stellar Population Properties

Author

Clerici, K. Slodkowski, Schnorr-Müller, A., Trevisan, M., and Ricci, T. V.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We investigated the stellar population properties of a sample of 1858 massive compact galaxies (MCGs) extracted from the SDSS survey. Motivated by previous results showing that older compact galaxies tend to have larger velocity dispersion at fixed stellar mass, we used the distance to the $\sigma_\mathrm{e}$ vs. $R_\mathrm{e}$ and $M_\star$ vs. $\sigma_\mathrm{e}$ relations as selection criteria. We found that MCGs are old ($\gtrsim 10$ Gyr), $\alpha$-enhanced ([$\alpha/\mathrm{Fe}] \sim 0.2$) and have solar to super-solar stellar metallicities. Metallicity increases with $\sigma_\mathrm{e}$, while age and [$\alpha$/Fe] do not vary significantly. Moreover, at fixed $\sigma_\mathrm{e}$, metallicity and stellar mass are correlated. Compared to a control sample of typical quiescent galaxies, MCGs have, on average, lower metallicities than control sample galaxies (CSGs) of similar $\sigma_\mathrm{e}$. For $\sigma_\mathrm{e} \lesssim 225$ km/s, MCGs are older and more $\alpha$-enhanced than CSGs, while for higher $\sigma_\mathrm{e}$ ages and $\alpha$-enhancement are similar. The differences in age and $\alpha$-enhancement can be explained by lower-$\sigma_\mathrm{e}$ CSGs being an amalgam of quiescent galaxies with a variety of ages. The origin of the differences in metallicity, however, is not clear. Lastly, we compared the stellar mass within the region probed by the SDSS fiber finding that, at fixed fiber velocity dispersion, MCGs have lower stellar masses on average. Since the velocity dispersion is a tracer of the dynamical mass, this raises the possibility that MCGs have, on average, a bottom heavier initial mass function or a larger dark matter fraction within the inner $\sim 1-2$ kpc., Comment: Accepted for publication in MNRAS

Published
2024

6. Unprescribed cannabinoids and multiple sclerosis: a multicenter, cross-sectional, epidemiological study in Lombardy, Italy

Author

Giossi, Riccardo, Mercenari, Martina, Filippi, Massimo, Zanetta, Chiara, Antozzi, Carlo Giuseppe, Brambilla, Laura, Confalonieri, Paolo, Crisafulli, Sebastiano Giuseppe, Tomas Roldan, Eugenia, Annovazzi, Pietro, Conti, Marta Zaffira, Barrilà, Caterina, Ronzoni, Marco, Grobberio, Monica, Negri, Attilio, Gustavsen, Stefan, and Torri Clerici, Valentina

Published
2024
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7. Active and non-active secondary progressive multiple sclerosis patients exhibit similar disability progression: results of an Italian MS registry study (ASPERA)

Author

Chisari, Clara Grazia, Amato, Maria Pia, Di Sapio, Alessia, Foschi, Matteo, Iaffaldano, Pietro, Inglese, Matilde, Fermo, Salvatore Lo, Lugaresi, Alessandra, Lus, Giacomo, Mascoli, Nerina, Montepietra, Sara, Pesci, Ilaria, Quatrale, Rocco, Salemi, Giuseppe, Torri Clerici, Valentina, Totaro, Rocco, Valentino, Paola, Filippi, Massimo, and Patti, Francesco

Published
2024
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9. Boundary Treatment for Variational Quantum Simulations of Partial Differential Equations on Quantum Computers

Author

Over, Paul, Bengoechea, Sergio, Rung, Thomas, Clerici, Francesco, Scandurra, Leonardo, de Villiers, Eugene, and Jaksch, Dieter

Subjects
Quantum Physics, Physics - Fluid Dynamics
Abstract

The paper presents a variational quantum algorithm to solve initial-boundary value problems described by second-order partial differential equations. The approach uses hybrid classical/quantum hardware that is well suited for quantum computers of the current noisy intermediate-scale quantum era. The partial differential equation is initially translated into an optimal control problem with a modular control-to-state operator (ansatz). The objective function and its derivatives required by the optimizer can efficiently be evaluated on a quantum computer by measuring an ancilla qubit, while the optimization procedure employs classical hardware. The focal aspect of the study is the treatment of boundary conditions, which is tailored to the properties of the quantum hardware using a correction technique. For this purpose, the boundary conditions and the discretized terms of the partial differential equation are decomposed into a sequence of unitary operations and subsequently compiled into quantum gates. The accuracy and gate complexity of the approach are assessed for second-order partial differential equations by classically emulating the quantum hardware. The examples include steady and unsteady diffusive transport equations for a scalar property in combination with various Dirichlet, Neumann, or Robin conditions. The results of this flexible approach display a robust behavior and a strong predictive accuracy in combination with a remarkable polylog complexity scaling in the number of qubits of the involved quantum circuits. Remaining challenges refer to adaptive ansatz strategies that speed up the optimization procedure.

Published
2024

11. Correction to: Progression independent of relapse activity in relapsing multiple sclerosis: impact and relationship with secondary progression

Author

Portaccio, Emilio, Betti, Matteo, De Meo, Ermelinda, Addazio, Ilaria, Pastò, Luisa, Razzolini, Lorenzo, Totaro, Rocco, Spitaleri, Daniele, Lugaresi, Alessandra, Cocco, Eleonora, Onofrj, Marco, Di Palma, Franco, Patti, Francesco, Maimone, Davide, Valentino, Paola, Clerici, Valentina Torri, Protti, Alessandra, Ferraro, Diana, Lus, Giacomo, Maniscalco, Giorgia Teresa, Morra, Vincenzo Brescia, Salemi, Giuseppe, Granella, Franco, Pesci, Ilaria, Bergamaschi, Roberto, Aguglia, Umberto, Vianello, Marika, Simone, Marta, Lepore, Vito, Iaffaldano, Pietro, Comi, Giancarlo, Filippi, Massimo, Trojano, Maria, and Amato, Maria Pia

Published
2024
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12. Predicted Expenditure for Prescription Drugs for Multiple Sclerosis in the Italian Market Between 2023 and 2028: Results of the Oracle Project

Author

Paolicelli, Damiano, Borriello, Giovanna, Clerici, Raffaella, Colombo, Elena, Croce, Davide, D’Amico, Emanuele, De Rossi, Nicola, Di Sapio, Alessia, Fenu, Giuseppe, Maimone, Davide, Marfia, Girolama A., Moccia, Marcello, Perini, Paola, Piscaglia, Maria G., Razzolini, Lorenzo, Riccaboni, Massimo, Signoriello, Elisabetta, Agostoni, Gianluca, Farina, Alberto, Mondino, Margaret, Berruto, Francesco, Tettamanti, Alessia, Donnaloja, Francesca, and Tortorella, Carla

Published
2024
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14. Progression independent of relapse activity in relapsing multiple sclerosis: impact and relationship with secondary progression

Author

Portaccio, Emilio, Betti, Matteo, De Meo, Ermelinda, Addazio, Ilaria, Pastò, Luisa, Razzolini, Lorenzo, Totaro, Rocco, Spitaleri, Daniele, Lugaresi, Alessandra, Cocco, Eleonora, Onofrj, Marco, Di Palma, Franco, Patti, Francesco, Maimone, Davide, Valentino, Paola, Torri Clerici, Valentina, Protti, Alessandra, Ferraro, Diana, Lus, Giacomo, Maniscalco, Giorgia Teresa, Brescia Morra, Vincenzo, Salemi, Giuseppe, Granella, Franco, Pesci, Ilaria, Bergamaschi, Roberto, Aguglia, Umberto, Vianello, Marika, Simone, Marta, Lepore, Vito, Iaffaldano, Pietro, Comi, Giancarlo, Filippi, Massimo, Trojano, Maria, and Amato, Maria Pia

Published
2024
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19. High-power sub-picosecond filamentation at 1.03 {\mu}m with high repetition rates between 10 and 100 kHz

Author

Löscher, Robin, Moreno, Victor, Adamou, Dionysis, Kesim, Denizhan K., Schroeder, Malte C., Clerici, Matteo, Wolf, Jean-Pierre, and Saraceno, Clara J.

Subjects
Physics - Optics, Physics - Plasma Physics
Abstract

Filamentation has extensively been explored and is well understood at repetition rates <1 kHz due to the typical availability of multi-mJ laser systems at a moderate average power. The advent of high-power Yb-lasers opened new possibilities for filamentation research. However, so far, high average power Yb systems have mostly been explored to increase the driving pulse energy to several hundreds of mJ and not at significantly higher repetition rates. In this paper, we study, for the first time, long filaments at unprecedented high repetition rates of 10, 40, and 100 kHz using a 500-W Yb-doped thin-disk amplifier driver operating with sub-700 fs pulses. We compare the filament length, density hole, and fluorescence at a constant peak power but different repetition rates and find a strong dependence on filament length and density depletion with repetition rate. Our analysis reveals the emergence of a significant stationary density depletion at repetition rates of 40 and 100 kHz. The corresponding reduction in the breakdown threshold by increasing the laser repetition rate observed in our study signifies a promising avenue for enhancing the efficiency and reliability of electric discharge triggering in various scenarios. Using capacitive plasma probe measurements, we address the limitations of fluorescence imaging-based measurements and demonstrate a systematic underestimation of filament length. This work contributes to a deeper understanding of the interplay between laser repetition rates, filamentation, and heat-driven density depletion effects from high-repetition-rate high-power laser systems and will contribute to guiding future research, making use of filaments at high repetition rates.

Published
2023
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20. Advanced presentation of cardiac hemangioma

Author

Francesco Rattenni, Francesco Giuseppe Arlati, Andrea Galanti, Fabrizio Sansone, Alberto Clerici, Michele Triggiani, and Claudio Muneretto

Subjects
Congenital cardiac tumors, Primary cardiac neoplasms, Cardiac hemangioma, Acute heart failure, Surgery, RD1-811, Anesthesiology, RD78.3-87.3
Abstract

Abstract Cardiac hemangioma is a rare, benign vascular primary tumor. Clinical presentation is either asymptomatic or with symptoms due to its location and spatial interaction with adjacent structures. The authors present a case of right cardiac hemangioma whose clinical diagnosis was triggered by symptoms of anasarca status, hepatic damage with ascites, pleural effusion and right heart failure. The 79 years-old patient has been treated with complete resection of the tumor by means of cardiopulmonary bypass, without complications. The mid-term outcome (12 months) was favorable. The aim of this study is to report a case of cardiac hemangioma with relevant dimensions, in a rare location (tricuspid valve) with acute onset and interesting aspects of clinical presentation.

Published
2024
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21. Poderes partidarios y reclutamiento ministerial. El caso argentino

Author

Marcelo Camerlo, Paula Clerici, and Anabella Molina

Subjects
argentina, cabinets, ministerial recruitment, partisan powers, presidentialism, International relations, JZ2-6530, Political science (General), JA1-92
Abstract

Objective/context: Party recruitment is a crucial governance tool in contemporary democracies. Presidential and parliamentary heads of government distribute ministerial portfolios to party members in exchange for essential political resources, such as legislative support. This article explores the relationship between government formation and political parties, with parties that are not very institutionalized. In particular, it examines the extent to which arguments about presidential cabinet formation hold up when the hierarchical level of party ministers is considered. Methodology: This statistical study uses a generalized linear model (GLM) with a binomial distribution and a logit link function with robust standard errors. It aims to carry out causality exploration to test the original indicators of the proposed dependent variables. Conclusions: Hierarchy and partisan powers are relevant factors to complement existing explanations of ministerial recruitment strategies. Originality: Comparative research on government formation and its connection to political parties has made significant progress, focusing on the distinction between ministers affiliated and not affiliated with a party. However, this dichotomous approach neglects consideration of the hierarchical position within the party structure, a fundamental aspect of the governing party model underlying parliamentary democracies. This article presents a trichotomous measure that considers the hierarchical level of ministers.

Published
2024
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22. A complex remodeling of cellular homeostasis distinguishes RSV/SARS-CoV-2 co-infected A549-hACE2 expressing cell lines

Author

Claudia Vanetti, Irma Saulle, Valentina Artusa, Claudia Moscheni, Gioia Cappelletti, Silvia Zecchini, Sergio Strizzi, Micaela Garziano, Claudio Fenizia, Antonella Tosoni, Martina Broggiato, Pasquale Ogno, Manuela Nebuloni, Mario Clerici, Daria Trabattoni, Fiona Limanaqi, and Mara Biasin

Subjects
respiratory syncytial virus (rsv), sars-cov-2, co-infection, cellular homeostasis, autophagy, Biology (General), QH301-705.5
Abstract

Concurrent infections with two or more pathogens with analogous tropism, such as RSV and SARS-CoV-2, may antagonize or facilitate each other, modulating disease outcome. Clinically, discrepancies in the severity of symptoms have been reported in children with RSV/SARS-CoV-2 co-infection. Herein, we propose an in vitro co-infection model to assess how RSV/SARS-CoV-2 co-infection alters cellular homeostasis. To this end, A549-hACE2 expressing cells were either infected with RSV or SARS-CoV-2 alone or co-infected with both viruses. Viral replication was assessed at 72 hours post infection by droplet digital PCR, immunofluorescence, and transmission electron microscopy. Anti-viral/receptor/autophagy gene expression was evaluated by RT-qPCR and confirmed by secretome analyses and intracellular protein production. RSV/SARS-CoV-2 co-infection in A549-hACE2 cells was characterized by: 1) an increase in the replication rate of RSV compared to single infection; 2) an increase in one of the RSV host receptors, ICAM1; 3) an upregulation in the expression/secretion of pro-inflammatory genes; 4) a rise in the number and length of cellular conduits; and 5) augmented autophagosomes formation and/or alteration of the autophagy pathway. These findings suggest that RSV/SARS-CoV-2 co-infection model displays a unique and specific viral and molecular fingerprint and shed light on the viral dynamics during viral infection pathogenesis. This in vitro co-infection model may represent a potential attractive cost-effective approach to mimic both viral dynamics and host cellular responses, providing in future readily measurable targets predictive of co-infection progression.

Published
2024
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23. One-Year Real-World Outcomes of Intravitreal Faricimab for Previously Treated Neovascular Age-Related Macular Degeneration

Author

Giuseppe Cancian, Arianna Paris, Lia Agliati, Angelica Rizzato, Michele Clerici, Giulio Volpe, Moreno Menghini, and Gabriela Grimaldi

Subjects
Age-related macular degeneration, Faricimab, Anti-VEGF, Switcher, Poor responder, Ophthalmology, RE1-994
Abstract

Abstract Introduction This study assessed the efficacy, durability, and safety of faricimab in patients with neovascular age-related macular degeneration (nAMD), previously treated with aflibercept or ranibizumab with unsatisfactory results. Methods This was a single-center, prospective cohort study of all consecutive patients with nAMD switched to intravitreally administered faricimab from traditional anti-vascular endothelial growth factor (anti-VEGF) treatments between September 2022 and April 2023 because of unsatisfactory response (maximal fluid-free interval ≤ 8 weeks). Faricimab was administered with a loading dose of four 4-weekly injections, followed by a treat-and-extend regimen. The primary outcome measures were maximum fluid-free interval after the switch and last assigned treatment interval. Secondary outcome measures included best-corrected visual acuity (BCVA) and structural optical coherence tomography parameters. Results Thirty-three eyes of 33 patients were included. Patients were followed for a median of 72 weeks [interquartile range 61, 76]. Median maximum fluid-free treatment interval after switch to faricimab and the last assigned interval were significantly longer than before the switch (7 vs. 4 weeks, p

Published
2024
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24. Intravitreal faricimab for treatment naïve patients with neovascular age-related macular degeneration: a real-world prospective study

Author

Gabriela Grimaldi, Giuseppe Cancian, Arianna Paris, Michele Clerici, Giulio Volpe, and Moreno Menghini

Subjects
Faricimab, Age-related macular degeneration, Anti-vascular endothelial growth factor, Anti-angiopoietin 2, Treat-and-extend, Ophthalmology, RE1-994
Abstract

Abstract Background Intravitreal faricimab, a bispecific antibody targeting both angiopoietin-2 (Ang-2) and vascular endothelial growth factor-A (VEGF-A), was recently introduced for the treatment of neovascular age-related macular degeneration (nAMD), diabetic macular oedema and cystoid macular oedema secondary to retinal vein occlusion. The aim of our study was to assess the efficacy, safety and durability of intravitreal faricimab in a real-world cohort of treatment-naïve patients with nAMD. Methods Single-centre, prospective cohort study of 21 eyes from 19 treatment-naïve nAMD patients who were treated with intravitreal faricimab from October 2022 to April 2024. Patients underwent a loading dose (LD) of 4 monthly faricimab injections followed by a treat-and-extend regimen. Primary outcomes included best-corrected visual acuity (BCVA) and structural parameters from spectral-domain optical coherence tomography (SD-OCT). Secondary outcomes included the proportion of eyes achieving a dry macula, maximal fluid-free interval and intended interval at last follow-up. Results The study included 21 eyes of 19 patients (mean age 83.1 years). After LD, 93.3% of eyes achieved a dry macular SD-OCT scan within a median time of 8 weeks. At the first extension, 53% of eyes remained dry, while 47% showed fluid recurrence. Long-term analysis (n = 14) revealed significant reductions in macular volume (MV), central subfield thickness (CST), and pigment epithelial detachment (PED) height over a median follow-up of 64.9 weeks, with sustained visual and anatomical improvements. Median BCVA, CST, and MV at the final follow-up were significantly improved from baseline (p

Published
2024
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25. A comparison of natalizumab and ocrelizumab on disease progression in multiple sclerosis

Author

Pietro Iaffaldano, Giuseppe Lucisano, Tommaso Guerra, Damiano Paolicelli, Emilio Portaccio, Matilde Inglese, Matteo Foschi, Francesco Patti, Franco Granella, Silvia Romano, Paola Cavalla, Giovanna De Luca, Paolo Gallo, Paolo Bellantonio, Antonio Gallo, Sara Montepietra, Alessia Di Sapio, Marika Vianello, Rocco Quatrale, Daniele Spitaleri, Raffaella Clerici, Valentina Torri Clerici, Eleonora Cocco, Vincenzo Brescia Morra, Girolama Alessandra Marfia, Vincenzo Daniele Boccia, Massimo Filippi, Maria Pia Amato, Maria Trojano, and the Italian MS Register

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Objective No direct comparisons of the effect of natalizumab and ocrelizumab on progression independent of relapse activity (PIRA) and relapse‐associated worsening (RAW) events are currently available. We aimed to compare the risk of achieving first 6 months confirmed PIRA and RAW events and irreversible Expanded Disability Status Scale (EDSS) 4.0 and 6.0 in a cohort of naïve patients treated with natalizumab or ocrelizumab from the Italian Multiple Sclerosis Register. Methods Patients with a first visit within 1 year from onset, treated with natalizumab or ocrelizumab, and ≥3 visits were extracted. Pairwise propensity score‐matched analyses were performed. Risk of reaching the first PIRA, RAW, and EDSS 4.0 and 6.0 events were estimated using multivariable Cox proportional hazards models. Kaplan–Meier curves were used to show cumulative probabilities of reaching outcomes. Results In total, 770 subjects were included (natalizumab = 568; ocrelizumab = 212) and the propensity score‐matching retrieved 195 pairs. No RAW events were found in natalizumab group and only 1 was reported in ocrelizumab group. A first PIRA event was reached by 23 natalizumab and 25 ocrelizumab exposed patients; 7 natalizumab‐ and 10 ocrelizumab‐treated patients obtained an irreversible EDSS 4.0, while 13 natalizumab‐ and 15 ocrelizumab‐treated patients reached an irreversible EDSS 6.0. No differences between the two groups were found in the risk (HR, 95%CI) of reaching a first PIRA (1.04, 0.59–1.84; p = 0.88) event, an irreversible EDSS 4.0 (1.23, 0.57–2.66; p = 0.60) and 6.0 (0.93, 0.32–2.68; p = 0.89). Interpretation Both medications strongly suppress RAW events and, in the short term, the risk of achieving PIRA events, EDSS 4.0 and 6.0 milestones is not significantly different.

Published
2024
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26. The Origin of Massive Compact Galaxies: Lessons from IllustrisTNG

Author

Lohmann, F. S., Schnorr-Müller, A., Trevisan, M., Ricci, T. V., and Clerici, K. Slodkowski

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We investigate the formation and evolution of z=0 massive compact galaxies (MCGs) in the IllustrisTNG cosmological simulation. We found that, as in observations, MCGs are mainly old (median age $\sim 10.8$ Gyr), have super-solar metallicities (median $\log Z/Z_{\odot}\sim0.35$) and are $\alpha$-enhanced (median $[\alpha/Fe]\sim0.25$). The age distribution extends to younger ages, however, and a few MCGs are as young as $\sim7$ Gyr. In general, MCGs assemble their mass early and accrete low angular momentum gas, significantly increasing their mass while growing their size much slower. A small fraction of MCGs follow another evolutionary path, going through a compaction event, with their sizes shrinking by 40% or more. The accretion of low angular momentum gas leads to enhanced SMBH growth, and MCGs reach the threshold SMBH mass of $\log M_\mathrm{BH}\sim10^{8.5} M_\odot$ - when kinetic AGN feedback kicks in and quenches the galaxy - earlier than non-compact galaxies. Comparing MCGs to a sample of median-sized quiescent galaxies matched in effective velocity dispersion, we find that their accretion histories are very different. 71% of MCGs do not merge after quenching compared to 37% of median-sized quiescent galaxies. Moreover, tracing these populations back in time, we find that at least a third of median-sized quiescent galaxies do not have a compact progenitor, underscoring that both dry mergers and progenitor bias effects are responsible for the differences in the kinematics and stellar population properties of MCGs and median-sized quiescent galaxies., Comment: 15 pages, 15 figures (not including appendices). Accepted for publication in the Monthly Notices of the Royal Astronomical Society

Published
2023
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27. Correction to: Unprescribed cannabinoids and multiple sclerosis: a multicenter, cross-sectional, epidemiological study in Lombardy, Italy

Author

Giossi, Riccardo, Mercenari, Martina, Filippi, Massimo, Zanetta, Chiara, Antozzi, Carlo Giuseppe, Brambilla, Laura, Confalonieri, Paolo, Crisafulli, Sebastiano Giuseppe, Tomas Roldan, Eugenia, Annovazzi, Pietro, Conti, Marta Zaffira, Barrilà, Caterina, Ronzoni, Marco, Grobberio, Monica, Negri, Attilio, Gustavsen, Stefan, and Torri Clerici, Valentina

Published
2024
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28. Correction to: Frequency and clinical correlates of anti-nerve antibodies in a large population of CIDP patients included in the Italian database

Author

Liberatore, Giuseppe, De Lorenzo, Alberto, Giannotta, Claudia, Manganelli, Fiore, Filosto, Massimiliano, Cosentino, Giuseppe, Cocito, Dario, Briani, Chiara, Cortese, Andrea, Fazio, Raffaella, Lauria, Giuseppe, Clerici, Angelo Maurizio, Rosso, Tiziana, Marfia, Girolama Alessandra, Antonini, Giovanni, Cavaletti, Guido, Carpo, Marinella, Doneddu, Pietro Emiliano, Spina, Emanuele, Cotti Piccinelli, Stefano, Peci, Erdita, Querol, Luis, and Nobile‑Orazio, Eduardo

Published
2024
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34. Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago

Author

Perrone, Gennaro, Giuffrida, Mario, Abu-Zidan, Fikri, Kruger, Vitor F., Livrini, Marco, Petracca, Gabriele Luciano, Rossi, Giorgio, Tarasconi, Antonio, Tian, Brian W. C. A., Bonati, Elena, Mentz, Ricardo, Mazzini, Federico N., Campana, Juan P., Gasser, Elisabeth, Kafka-Ritsch, Reinhold, Felsenreich, Daniel M., Dawoud, Christopher, Riss, Stefan, Gomes, Carlos Augusto, Gomes, Felipe Couto, Gonzaga, Ricardo Alessandro Teixeira, Canton, Cassio Alfred Brattig, Pereira, Bruno Monteiro, Fraga, Gustavo P., Zem, Leticia Gonçalves, Cordeiro-Fonseca, Vinicius, de Mesquita Tauil, Renato, Atanasov, Boyko, Belev, Nikolay, Kovachev, Nikola, Meléndez, L. Juan José, Dimova, Ana, Dimov, Stefan, Zelić, Zdravko, Augustin, Goran, Bogdanić, Branko, Morić, Trpimir, Chouillard, Elie, Bajul, Melinda, De Simone, Belinda, Panis, Yves, Esposito, Francesco, Notarnicola, Margherita, Lauka, Lelde, Fabbri, Anna, Hentati, Hassen, Fnaiech, Iskander, Aurélien, Venara, Bougard, Marie, Roulet, Maxime, Demetrashvili, Zaza, Pipia, Irakli, Merabishvili, Giorgi, Bouliaris, Konstantinos, Koukoulis, Georgios, Doudakmanis, Christos, Xenaki, Sofia, Chrysos, Emmanuel, Kokkinakis, Stamatios, Vassiliu, Panteleimon, Michalopoulos, Nikolaos, Margaris, Ioannis, Kechagias, Aristotelis, Avgerinos, Konstantinos, Katunin, Jevgeni, Lostoridis, Eftychios, Nagorni, Eleni-Aikaterini, Pujante, Antonio, Mulita, Francesk, Maroulis, Ioannis, Vailas, Michail, Marinis, Athanasios, Siannis, Ioannis, Bourbouteli, Eirini, Manatakis, Dimitrios K., Tasis, Nikolaos, Acheimastos, Vasileios, Maria, Sotiropoulou, Stylianos, Kapiris, Kuzeridis, Harilaos, Korkolis, Dimitrios, Fradelos, Evangelos, Kavalieratos, George, Petropoulou, Thalia, Polydorou, Andreas, Papacostantinou, Ioannis, Triantafyllou, Tania, Kimpizi, Despina, Theodorou, Dimitrios, Toutouzas, Konstantinos, Chamzin, Alexandros, Frountzas, Maximos, Schizas, Dimitrios, Karavokyros, Ioannis, Syllaios, Athanasios, Charalabopoulos, Alexandros, Boura, Maria, Baili, Efstratia, Ioannidis, Orestis, Loutzidou, Lydia, Anestiadou, Elissavet, Tsouknidas, Ioannis, Petrakis, Georgios, Polenta, Eleni, Bains, Lovenish, Gupta, Rahul, Singh, Sudhir K., Khanduri, Archana, Bala, Miklosh, Kedar, Asaf, Pisano, Marcello, Podda, Mauro, Pisanu, Adolfo, Martines, Gennaro, Trigiante, Giuseppe, Lantone, Giuliano, Agrusa, Antonino, Di Buono, Giuseppe, Buscemi, Salvatore, Veroux, Massimiliano, Gioco, Rossella, Veroux, Gastone, Oragano, Luigi, Zonta, Sandro, Lovisetto, Federico, Feo, Carlo V., Pesce, Antonio, Fabbri, Nicolò, Lantone, Giulio, Marino, Fabio, Perrone, Fabrizio, Vincenti, Leonardo, Papagni, Vincenzo, Picciariello, Arcangelo, Rossi, Stefano, Picardi, Biagio, Del Monte, Simone Rossi, Visconti, Diego, Osella, Giulia, Petruzzelli, Luca, Pignata, Giusto, Andreuccetti, Jacopo, D’Alessio, Rossella, Buonfantino, Massimo, Guaitoli, Eleonora, Spinelli, Stefano, Sampietro, Gianluca Matteo, Corbellini, Carlo, Lorusso, Leonardo, Frontali, Alice, Pezzoli, Isabella, Bonomi, Alessandro, Chierici, Andrea, Cotsoglou, Christian, Manca, Giuseppe, Delvecchio, Antonella, Musa, Nicola, Casati, Massimiliano, Letizia, Laface, Abate, Emmanuele, Ercolani, Giorgio, D’Acapito, Fabrizio, Solaini, Leonardo, Guercioni, Gianluca, Cicconi, Simone, Sasia, Diego, Borghi, Felice, Giraudo, Giorgio, Sena, Giuseppe, Castaldo, Pasquale, Cardamone, Eugenia, Portale, Giuseppe, Zuin, Matteo, Spolverato, Ylenia, Esposito, Marialusia, Isernia, Roberta Maria, Di Salvo, Maria, Manunza, Romina, Esposito, Giuseppe, Agus, Marcello, Asti, Emanuele Luigi Giuseppe, Bernardi, Daniele Tiziano, Tonucci, Tommaso Panici, Luppi, Davide, Casadei, Massimiliano, Bonilauri, Stefano, Pezzolla, Angela, Panebianco, Annunziata, Laforgia, Rita, De Luca, Maurizio, Zese, Monica, Parini, Dario, Jovine, Elio, De Sario, Giuseppina, Lombardi, Raffaele, Aprea, Giovanni, Palomba, Giuseppe, Capuano, Marianna, Argenio, Giulio, Orio, Gianluca, Armellino, Mariano Fortunato, Troian, Marina, Guerra, Martina, Nagliati, Carlo, Biloslavo, Alan, Germani, Paola, Aizza, Giada, Monsellato, Igor, Chahrour, Ali Chaouki, Anania, Gabriele, Bombardini, Cristina, Bagolini, Francesco, Sganga, Gabriele, Fransvea, Pietro, Bianchi, Valentina, Boati, Paolo, Ferrara, Francesco, Palmieri, Francesco, Cianci, Pasquale, Gattulli, Domenico, Restini, Enrico, Cillara, Nicola, Cannavera, Alessandro, Nita, Gabriela Elisa, Sarnari, Jlenia, Roscio, Francesco, Clerici, Federico, Scandroglio, Ildo, Berti, Stefano, Cadeo, Alessandro, Filippelli, Alice, Conti, Luigi, Grassi, Carmine, Cattaneo, Gaetano Maria, Pighin, Marina, Papis, Davide, Gambino, Giovanni, Bertino, Vanessa, Schifano, Domenico, Prando, Daniela, Fogato, Luisella, Cavallo, Fabio, Ansaloni, Luca, Picheo, Roberto, Pontarolo, Nicholas, Depalma, Norma, Spampinato, Marcello, D’Ugo, Stefano, Lepre, Luca, Capponi, Michela Giulii, Campa, Rossella Domenica, Sarro, Giuliano, Dinuzzi, Vincenza Paola, Olmi, Stefano, Uccelli, Matteo, Ferrari, Davide, Inama, Marco, Moretto, Gianluigi, Fontana, Michele, Favi, Francesco, Picariello, Erika, Rampini, Alessia, Barberis, Andrea, Azzinnaro, Antonio, Oliva, Alba, Totaro, Luigi, Benzoni, Ilaria, Ranieri, Valerio, Capolupo, Gabriella Teresa, Carannante, Filippo, Caricato, Marco, Ronconi, Maurizio, Casiraghi, Silvia, Casole, Giovanni, Pantalone, Desire, Alemanno, Giovanni, Scheiterle, Maximilian, Ceresoli, Marco, Cereda, Marco, Fumagalli, Chiara, Zanzi, Federico, Bolzon, Stefano, Guerra, Enrico, Lecchi, Francesca, Cellerino, Paola, Ardito, Antonella, Scaramuzzo, Rosa, Balla, Andrea, Lepiane, Pasquale, Tartaglia, Nicola, Ambrosi, Antonio, Pavone, Giovanna, Palini, Gian Marco, Veneroni, Simone, Garulli, Gianluca, Ricci, Claudio, Torre, Beatrice, Russo, Iris Shari, Rottoli, Matteo, Tanzanu, Marta, Belvedere, Angela, Milone, Marco, Manigrasso, Michele, De Palma, Giovanni Domenico, Piccoli, Micaela, Pattacini, Gianmaria Casoni, Magnone, Stefano, Bertoli, Paolo, Pisano, Michele, Massucco, Paolo, Palisi, Marco, Luzzi, Andrea-Pierre, Fleres, Francesco, Clarizia, Guglielmo, Spolini, Alessandro, Kobe, Yoshiro, Toma, Takayuki, Shimamura, Fumihiko, Parker, Robert, Ranketi, Sinkeet, Mitei, Mercy, Svagzdys, Saulius, Pauzas, Henrikas, Zilinskas, Justas, Poskus, Tomas, Kryzauskas, Marius, Jakubauskas, Matas, Zakaria, Andee Dzulkarnaen, Zakaria, Zaidi, Wong, Michael Pak-Kai, Jusoh, Asri Che, Zakaria, Muhammad Nazreen, Cruz, Daniel Rios, Elizalde, Aurea Barbara Rodriguez, Reynaud, Alejandro Bañon, Hernandez, Edgard Efren Lozada, Monroy, Jose maria Victor Palomo, Hinojosa-Ugarte, Diego, Quiodettis, Martha, Du Bois, María Esther, Latorraca, José, Major, Piotr, Pędziwiatr, Michał, Pisarska-Adamczyk, Magdalena, Walędziak, Maciej, Kwiatkowski, Andrzej, Czyżykowski, Łukasz, da Costa, Silvia Dantas, Pereira, Bela, Ferreira, Ana Rita Oliveira, Almeida, Filipe, Rocha, Ricardo, Carneiro, Carla, Perez, Diego Pita, Carvas, João, Rocha, Catarina, Ferreira, Cátia, Marques, Rita, Fernandes, Urânia, Leao, Pedro, Goulart, André, Pereira, Rita Gonçalves, Patrocínio, Sara Daniela Direito, de Mendonça, Nuno Gonçalo Gonçalves, Manso, Maria Isabel Cerqueira, Morais, Henrique Manuel Cardoso, Cardoso, Paulo Sebastião, Calu, Valentin, Miron, Adrian, Toma, Elena Adelina, Gachabayov, Mahir, Abdullaev, Abakar, Litvin, Andrey, Nechay, Taras, Tyagunov, Alexander, Yuldashev, Anvar, Bradley, Alison, Wilson, Michael, Panyko, Arpád, Látečková, Zuzana, Lacko, Vladimír, Lesko, Dusan, Soltes, Marek, Radonak, Jozef, Turrado-Rodriguez, Victor, Termes-Serra, Roser, Morales-Sevillano, Xavier, Lapolla, Pierfrancesco, Mingoli, Andrea, Brachini, Gioia, Degiuli, Maurizio, Sofia, Silvia, Reddavid, Rossella, de Manzoni Garberini, Andrea, Buffone, Angelica, del Pozo, Eduardo Perea, Aparicio-Sánchez, Daniel, Dos Barbeito, Sandra, Estaire-Gómez, Mercedes, Vitón-Herrero, Rebeca, de los Ángeles Gil Olarte-Marquez, Mª, Gil-Martínez, José, Alconchel, Felipe, Nicolás-López, Tatiana, Rahy-Martin, Aida Cristina, Pelloni, María, Bañolas-Suarez, Raquel, Mendoza-Moreno, Fernando, Nisa, Francisca García-Moreno, Díez-Alonso, Manuel, Rodas, María Elisa Valle, Agundez, María Carmona, Andrés, María Inmaculada Pérez, Moreira, Claudia Cristina Lopes, Perez, Aintzane Lizarazu, Ponce, Iñigo Augusto, González-Castillo, Ana María, Membrilla-Fernández, Estela, Salvans, Silvia, Serradilla-Martín, Mario, Pardo, Pablo Sancho, Rivera-Alonso, Daniel, Dziakova, Jana, Huguet, Jose Mugüerza, Valle, Naila Pagès, Ruiz, Enrique Colás, Valcárcel, Cristina Rey, Moreno, Cristina Ruiz, Salazar, Yeniffer Tatiana Moreno, García, Juan Jesús Rubio, Micó, Silvia Sevila, López, Joaquín Ruiz, Farré, Silvia Pérez, Gomez, Maite Santamaria, Petit, Nuria Mestres, Titos-García, Alberto, Aranda-Narváez, Jose Manuel, Romacho-López, Laura, Sánchez-Guillén, Luis, Aranaz-Ostariz, Veronica, Bosch-Ramírez, Marina, Martínez-Pérez, Aleix, Martínez-López, Elías, Sebastián-Tomás, Juan Carlos, Jimenez-Riera, Granada, Jimenez-Vega, Javier, Cuellar, Jose Aurelio Navas, Campos-Serra, Andrea, Muñoz-Campaña, Anna, Gràcia-Roman, Raquel, Alegre, Javier Martínez, Pinto, Francisca Lima, O’Sullivan, Sara Nuñez, Antona, Francisco Blanco, Jiménez, Beatriz Muñoz, López-Sánchez, Jaime, Carmona, Zahira Gómez, Fernández, Rocio Torres, Sierra, Isabel Blesa, de León, Laura Román García, Moreno, Verónica Polaino, Iglesias, Eva, Cumplido, Paola Lora, Bravo, Altea Arango, Simó, Ignacio Rey, Domínguez, Carlota López, Caamaño, Aloia Guerreiro, Lozano, Rafael Calleja, Martínez, Manuel Durán, Torres, Álvaro Naranjo, de Quiros, Javier Tomas Morales Bernaldo, Pellino, Gianluca, Cloquell, Miriam Moratal, Moller, Elsa García, Jalal-Eldin, Sami, Abdoun, Ahmed K., Hamid, Hytham K. S., Lohsiriwat, Varut, Mongkhonsupphawan, Aitsariya, Baraket, Oussama, Ayed, Karim, Abbassi, Imed, Ali, Ali Ben, Ammar, Houssem, Kchaou, Ali, Tlili, Ahmed, Zribi, Imen, Colak, Elif, Polat, Suleyman, Koylu, Zehra Alan, Guner, Ali, Usta, Mehmet Arif, Reis, Murat Emre, Mantoglu, Baris, Gonullu, Emre, Akin, Emrah, Altintoprak, Fatih, Bayhan, Zulfu, Firat, Necattin, Isik, Arda, Memis, Ufuk, Bayrak, Mehmet, Altıntaş, Yasemin, Kara, Yasin, Bozkurt, Mehmet Abdussamet, Kocataş, Ali, Das, Koray, Seker, Ahmet, Ozer, Nazmi, Atici, Semra Demirli, Tuncer, Korhan, Kaya, Tayfun, Ozkan, Zeynep, Ilhan, Onur, Agackiran, Ibrahim, Uzunoglu, Mustafa Yener, Demirbas, Eren, Altinel, Yuksel, Meric, Serhat, Hacım, Nadir Adnan, Uymaz, Derya Salim, Omarov, Nail, Balık, Emre, Tebala, Giovanni D., Khalil, Hany, Rana, Mridul, Khan, Mansoor, Florence, Charlotte, Swaminathan, Christie, Leo, Cosimo Alex, Liasis, Lampros, Watfah, Josef, Trostchansky, Ivan, Delgado, Edward, Pontillo, Marcelo, Latifi, Rifat, Coimbra, Raul, Edwards, Sara, Lopez, Ana, Velmahos, George, Dorken, Ander, Gebran, Anthony, Palmer, Amanda, Oury, Jeffrey, Bardes, James M., Seng, Sirivan Suon, Coffua, Lauren S., Ratnasekera, Asanthi, Egodage, Tanya, Echeverria-Rosario, Karla, Armento, Isabella, Napolitano, Lena M., Sangji, Naveen F., Hemmila, Mark, Quick, Jacob A., Austin, Tyler R., Hyman, Theodore S., Curtiss, William, McClure, Amanda, Cairl, Nicholas, Biffl, Walter L., Truong, Hung P., Schaffer, Kathryn, Reames, Summer, Banchini, Filippo, Capelli, Patrizio, Coccolini, Federico, Sartelli, Massimo, Bravi, Francesca, Vallicelli, Carlo, Agnoletti, Vanni, Baiocchi, Gian Luca, and Catena, Fausto

Published
2024
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39. Evaluation of drivers of treatment switch in relapsing multiple sclerosis: a study from the Italian MS Registry

Author

Iaffaldano, Pietro, Lucisano, Giuseppe, Guerra, Tommaso, Patti, Francesco, Cocco, Eleonora, De Luca, Giovanna, Brescia Morra, Vincenzo, Pozzilli, Carlo, Zaffaroni, Mauro, Ferraro, Diana, Gasperini, Claudio, Salemi, Giuseppe, Bergamaschi, Roberto, Lus, Giacomo, Inglese, Matilde, Romano, Silvia, Bellantonio, Paolo, Di Monte, Elisabetta, Maniscalco, Giorgia Teresa, Conte, Antonella, Lugaresi, Alessandra, Vianello, Marika, Torri Clerici, Valentina Liliana Adriana, Di Sapio, Alessia, Pesci, Ilaria, Granella, Franco, Totaro, Rocco, Marfia, Girolama Alessandra, Danni, Maura Chiara, Cavalla, Paola, Valentino, Paola, Aguglia, Umberto, Montepietra, Sara, Ferraro, Elisabetta, Protti, Alessandra, Spitaleri, Daniele, Avolio, Carlo, De Riz, Milena, Maimone, Davide, Cavaletti, Guido, Gazzola, Paola, Tedeschi, Gioacchino, Sessa, Maria, Rovaris, Marco, Di Palma, Franco, Gatto, Maurizia, Cargnelutti, Daniela, De Robertis̄, Francesca, Logullo, Francesco Ottavio, Rini, Augusto, Meucci, Giuseppe, Ardito, Bonaventura, Banfi, Paola, Nasuelli, Davide, Paolicelli, Damiano, Rocca, Maria Assunta, Portaccio, Emilio, Chisari, Clara Grazia, Fenu, Giuseppe, Onofrj, Marco, Carotenuto, Antonio, Ruggieri, Serena, Tortorella, Carla, Ragonese, Paolo, Nica, Mihaela, Amato, Maria Pia, Filippi, Massimo, and Trojano, Maria

Published
2024
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40. The DIVING$^\mathrm{3D}$ Survey - Deep IFS View of Nuclei of Galaxies - III. Analysis of the nuclear region of the early-type galaxies of the sample

Author

Ricci, T. V., Steiner, J. E., Menezes, R. B., Clerici, K. Slodkowski, and da Silva, M. D.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We analysed the nuclear region of all 56 early-type galaxies from the DIVING$^\mathrm{3D}$ Project, which is a statistically complete sample of objects that contains all 170 galaxies of the Southern Hemisphere with B < 12.0 mag and galactic latitude |b| < 15$^{\circ}$. Observations were performed with the Integral Field Unit of the Gemini Multi-Object Spectrograph. Emission lines were detected in the nucleus of 86$\pm$5% of the objects. Diagnostic diagrams were used to classify 52$\pm$7% of the objects as LINERs or Seyferts, while the other 34$\pm$6% galaxies without H$\beta$ or [O III] lines in their spectra were classified as weak emission line objects. Transition Objects are not seen in the sample, possibly because the seeing-limited data cubes of the objects allow one to isolate the nuclei of the galaxies from their circumnuclear regions, avoiding contamination from H II regions. A broad line region is seen in 29$\pm$6% of the galaxies. Of the 48 galaxies with emission-line nuclei, 41 have signs of AGNs. Some objects have also indications of shocks in their nuclei. Lenticular galaxies are more likely to have emission lines than ellipticals. Also, more luminous objects have higher [N II]/H$\alpha$ ratios, which may be associated with the mass-metalicity relation of galaxies. A direct comparison of our results with the Palomar Survey indicates that the detection rates of emission lines and also of type 1 AGNs are higher in the DIVING$^\mathrm{3D}$ objects. This is a consequence of using a more modern instrument with a better spatial resolution than the Palomar Survey observations., Comment: 16 pages (plus appendices), 6 figures, 9 tables, accepted for publication in MNRAS

Published
2023
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41. Predicted Expenditure for Prescription Drugs for Multiple Sclerosis in the Italian Market Between 2023 and 2028: Results of the Oracle Project

Author

Damiano Paolicelli, Giovanna Borriello, Raffaella Clerici, Elena Colombo, Davide Croce, Emanuele D’Amico, Nicola De Rossi, Alessia Di Sapio, Giuseppe Fenu, Davide Maimone, Girolama A. Marfia, Marcello Moccia, Paola Perini, Maria G. Piscaglia, Lorenzo Razzolini, Massimo Riccaboni, Elisabetta Signoriello, Gianluca Agostoni, Alberto Farina, Margaret Mondino, Francesco Berruto, Alessia Tettamanti, Francesca Donnaloja, and Carla Tortorella

Subjects
Multiple sclerosis, Costs, Forecast, Italian National Healthcare Service expenditure, BTKi, Treatment pattern, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Introduction Multiple sclerosis (MS) is a chronic neurodegenerative disease that leads to impaired cognitive function and accumulation of disability, with significant socioeconomic burden. Serious unmet need in the context of managing MS has given rise to ongoing research efforts, leading to the launch of new drugs planned for the near future, and subsequent concerns about the sustainability of healthcare systems. This study assessed the changes in the Italian MS market and their impact on the expenditures of the Italian National Healthcare Service between 2023 and 2028. Methods A horizon-scanning model was developed to estimate annual expenditure from 2023 to 2028. Annual expenditure for MS was calculated by combining the number of patients treated with each product (clinical inputs) and the yearly costs of therapy (economic inputs). Baseline inputs (2020–2022) were collected from IQVIA® real-world data, while input estimation for the 5-year forecast was integrated with analog analyses and the insights of clinicians and former payers. Results The number of equivalent patients treated in 2028 in Italy was estimated at around 67,000, with an increase of 10% versus 2022. In terms of treatment pattern evolution, first-line treatments are expected to reduce their shares from 47% in 2022 to 27% in 2028, and Bruton tyrosine kinase inhibitors are expected to reach 23% of patient shares. Overall, expenditure for MS is estimated to decrease from €721 million in 2022 to €551 million in 2028, mainly due to losses of exclusivity and renegotiation of drug prices. Conclusion Despite the increase in the number of patients treated for MS and the launch of new molecules that will reach high market penetration, the model confirmed sustainability for the Italian National Healthcare Service.

Published
2024
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42. Electrospun nanofibers incorporating lactobionic acid as novel active packaging materials: biological activities and toxicological evaluation

Author

Aline Aniele Vencato, Naiara Jacinta Clerici, André Luiz Mendes Juchem, Flavio Fonseca Veras, Helena Campos Rolla, and Adriano Brandelli

Subjects
Nanofibers, Lactobionic acid, Antibacterial activity, Antioxidant activity, Toxicological evaluation, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

Abstract In this study, lactobionic acid (LBA) was incorporated into poly(vinyl alcohol) (PVA) and poly(ε-caprolactone) (PCL) by electrospinning. The antimicrobial effects of the nanofibers were tested using the agar diffusion method. Only the PVA formulations showed antimicrobial activity against Staphylococcus aureus. The PVA and PCL nanofibers containing LBA showed antioxidant activity ranging from 690.33 to 798.67 µM TEAC when tested by the ABTS method. The characterization of nanofibers was performed by scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry, and mechanical analysis. The nanofibers showed a uniform morphology and their average diameters ranged from 295.5 to 2778.2 nm. The LBA addition induced a decrease in the enthalpy of fusion (ΔHm) of PVA and PCL nanofibers, while the Young’s modulus was reduced from 20 to 10 MPa in PCL and PCL-LBA nanofibers, respectively. No relevant differences were observed between the FTIR spectra of the control nanofibers and the nanofibers containing LBA. All nanofibers presented hemolysis rate below 2%, thus can be considered as non-hemolytic materials. Further toxicological assessment was performed with the selected formulation PVA10 + LBA. The evaluations by mutagenicity assay, cell survival measurement, cell viability analysis and agar diffusion cytotoxicity test indicated that there are no significant toxic effects. Electrospun nanofibers PVA-LBA and PCL-LBA were successfully produced, showing good thermal and mechanical properties and non-toxic effects. Furthermore, the nanofibers showed antimicrobial activity and antioxidant activity. The findings of this study indicate that PVA and PCL electrospun nanofibers incorporating LBA are promising for use in packaging applications.

Published
2024
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43. Product classes characterization at micro-scale level applied to granular wastes fractions

Author

Daniela Rizzo, Anna Somigliana, Stefania Marmai, Debora Cusumano, Laura Clerici, and Marco Volante

Subjects
Wastes, Product class characterization, Optical Microscopy, Scanning Electron Microscopy, Microanalysis, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

Abstract A product class characterization was requested on some plastic granular waste samples, already reduced in fine form with particles

Published
2024
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44. Linear Bandits with Memory: from Rotting to Rising

Author

Clerici, Giulia, Laforgue, Pierre, and Cesa-Bianchi, Nicolò

Subjects
Computer Science - Machine Learning
Abstract

Nonstationary phenomena, such as satiation effects in recommendations, have mostly been modeled using bandits with finitely many arms. However, the richer action space provided by linear bandits is often preferred in practice. In this work, we introduce a novel nonstationary linear bandit model, where current rewards are influenced by the learner's past actions in a fixed-size window. Our model, which recovers stationary linear bandits as a special case, leverages two parameters: the window size $m \ge 0$, and an exponent $\gamma$ that captures the rotting ($\gamma < 0)$ or rising ($\gamma > 0$) nature of the phenomenon. When both $m$ and $\gamma$ are known, we propose and analyze a variant of OFUL which minimizes regret against cycling policies. By choosing the cycle length so as to trade-off approximation and estimation errors, we then prove a bound of order $\sqrt{d}\,(m+1)^{\frac{1}{2}+\max\{\gamma,0\}}\,T^{3/4}$ (ignoring log factors) on the regret against the optimal sequence of actions, where $T$ is the horizon and $d$ is the dimension of the linear action space. Through a bandit model selection approach, our results are extended to the case where $m$ and $\gamma$ are unknown. Finally, we complement our theoretical results with experiments against natural baselines.

Published
2023

45. Serum miR-34a-5p, miR-103a-3p, and miR-376a-3p as possible biomarkers of conversion from relapsing-remitting to secondary progressive multiple sclerosis

Author

Simone Agostini, Roberta Mancuso, Lorenzo Agostino Citterio, Domenico Caputo, Letizia Oreni, Riccardo Nuzzi, Maria Barbara Pasanisi, Marco Rovaris, and Mario Clerici

Subjects
Multiple sclerosis, Relapsing remitting, Secondary progressive, miRNAs, Rehabilitation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Relapsing-remitting (RR) Multiple Sclerosis (MS) is the most common form of the disease; RRMS patients can maintain their clinical phenotype throughout life or can develop a secondary progressive (SP) course over time. We investigated whether circulating miRNAs can predict RR-to-SPMS conversion. A serum miRNAs profile was initially analyzed in a cross-sectional study by qPCR in 16 patients (8 RRMS and 8 SPMS) (Discovery cohort). Three miRNAs, i.e. miR-34a-5p, miR-103a-3p and miR-376a-3p, were significantly up-regulated in SPMS compared to RRMS patients (p

Published
2024
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46. Landscape connectivity loss after the de-escalation of armed conflict in the Colombian Amazon (2011–2021)

Author

Jesica López, Yuyang Qian, Paulo José Murillo-Sandoval, Nicola Clerici, and Lars Eklundh

Subjects
Landscape connectivity, CCDC, MSPA, Change detection, Land use, Cattle ranching, Ecology, QH540-549.5
Abstract

Rapid deforestation has been well-documented in Colombia after the 2016 peace agreement with FARC. While many analysis using remote sensing identify land cover change, structural connectivity variables are less studied for understanding landscape transformation. In this work, we used data from the Landsat archive from 2011 to 2021, the Continuous Change Detection and Classification algorithm (CCDC), and Morphological Spatial Pattern Analysis (MSPA) to analyze deforestation, land cover change, and landscape connectivity in northwestern Colombia’s Amazon. We examined the spatial patterns in three specific subsets in the Colombian arc of deforestation, with a special focus on the surroundings of the National Natural Park Serranía de Chiribiquete. Our results confirm changes in structural connectivity linked to pasture expansion from the conversion forest to pasture during the analyzed period showing changes in the borders of Serranía de Chiribiquete National Park along rivers and roads, where cattle is transported. Before 2016, the average annual deforested area in the three study areas was 27.93 km²; after 2016, this number increased to 73.36 km². The outcomes of our study contribute to an improved understanding of pasture dynamics. They can aid decision-making in areas that play a key role in ecological networks necessary for long-term conservation efforts. Our quantitative assessments have revealed a temporal shrinking of the core area, indicative of a decline in forest cover. Concurrently, we observed an expansion of the edge and background areas, which is consistent with the proliferation of pastures. This study presents methodology and data in support of policy-making for sustainable land use and ecological connectivity to mitigate further environmental degradation in the area.

Published
2024
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47. Coadministration of isavuconazole and sirolimus in allogeneic hematopoietic stem cell transplant recipients

Author

Francesca Farina, Andrea Acerbis, Chiara Oltolini, Matteo Chiurlo, Elisabetta Xue, Daniela Clerici, Sarah Marktel, Sara Mastaglio, Alessandro Bruno, Simona Piemontese, Elisa Diral, Giorgio Orofino, Edoardo Campodonico, Consuelo Corti, Maria Teresa Lupo Stanghellini, Paolo Scarpellini, Raffaele Dell’Acqua, Antonella Castagna, Iacopo Peccatori, Fabio Ciceri, and Raffaella Greco

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Background: Invasive fungal infections (IFIs) represent a major cause of morbidity among allogeneic hematopoietic stem cell transplantation (allo-HSCT). Isavuconazole (ISA) is a broad-spectrum triazole with favorable safety profile. Objectives and design: Herein, we evaluate the real life coadministration of ISA and sirolimus in allo-HSCT recipients in a single-center retrospective analysis, describing clinical efficacy, safety, and therapeutic drug monitoring (TDM) of both drugs. Methods: All consecutive allo-HSCT recipients who received the coadministration of ISA and sirolimus for at least 2 weeks between July 2017 and December 2022 were included in this retrospective analysis. TDM was longitudinally performed during treatment. IFIs were classified according to the revised European Organization for Research and Treatment of Cancer/Mycoses Study Group consensus criteria. Results: A total of 51 recipients were included in the analysis. A total of 17 patients received ISA as continuous antifungal treatment for IFI diagnosed before transplant: one patient experienced a probable invasive pulmonary aspergillosis, and one patient switched from ISA to liposomal amphotericin B for a possible IFI. A total of 34 patients started ISA as antifungal therapy for IFI diagnosed after transplant. Sixteen of 34 were treated for a proven/probable breakthrough IFI during mold-active prophylaxis: 6/16 patients died for IFI after a median of 51 days of ISA. Eighteen of 34 started ISA as empirical therapy for a possible IFI: 15/18 patients were alive with resolution of infection after 6 weeks, 1 died for disease progression, and 2 had empirically changed antifungal therapy due to pneumonia progression. Clinical and radiological response rate was 68% after 90 days from IFI diagnosis. No toxicities related to drug–drug interaction have been registered in patients reaching concomitant therapeutic levels of ISA and sirolimus. Conclusion: The coadministration of ISA and sirolimus was safe and feasible in this cohort, confirming favorable clinical efficacy in patients with multiple-drug coadministration.

Published
2024
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48. Immunopathology of lung transplantation: from infection to rejection and vice versa

Author

Ilaria Righi, Ivan Barone, Lorenzo Rosso, Letizia Corinna Morlacchi, Valeria Rossetti, Giovanni Caffarena, Fiona Limanaqi, Alessandro Palleschi, Mario Clerici, and Daria Trabattoni

Subjects
lung transplantation, infection, rejection, immune tolerance, immunosuppression, Immunologic diseases. Allergy, RC581-607
Abstract

Lung transplantation offers a lifesaving option for patients with end-stage lung disease, but it is marred by a high risk of post-transplant infections, particularly involving multidrug-resistant bacteria, Cytomegalovirus, and fungal pathogens. This elevated infection rate, the highest among solid organ transplants, poses a significant challenge for clinicians, particularly within the first year post-transplantation, where infections are the leading cause of mortality. The direct exposure of lung allografts to the external environment exacerbates this vulnerability leading to constant immune stimulation and consequently to an elevated risk of triggering alloimmune responses to the lung allograft. The necessity of prolonged immunosuppression to prevent allograft rejection further complicates patient management by increasing susceptibility to infections and neoplasms, and complicating the differentiation between rejection and infection, which require diametrically opposed management strategies. This review explores the intricate balance between preventing allograft rejection and managing the heightened infection risk in lung transplant recipients.

Published
2024
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49. Increased concentrations of P2X7R in oligodendrocyte derived extracellular vesicles of Multiple sclerosis patients

Author

Cristina Agliardi, Franca Rosa Guerini, Milena Zanzottera, Elisabetta Bolognesi, Domenico Caputo, Marco Rovaris, and Mario Clerici

Subjects
Multiple sclerosis, P2X7R, Oligodendrocytes derived extracellular vesicles, Exosomes, Biomarker, Primary progressive, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Activation of the purinergic receptor P2X7 (P2X7R) is believed to be deleterious in autoimmune diseases and it was hypothesized to play a role in the pathogenesis of MS. P2X7R is an ATP-gated non-selective cationic channel; its activation can be driven by high concentrations of ATP and leads to the generation of large, cytolytic conductance pores. P2X7R activation can also result in apoptosis as a consequence of the activation of the caspase cascade via P2X7R-dependent stimulation of the NLRP3 inflammasome. We measured P2X7R in oligodendrocyte derived extracellular vesicles (ODEVs) in MS patients and in healthy subjects.Sixty-eight MS patients (50 relapsing-remitting, RR-MS, 18 primary progressive, PP-MS) and 57 healthy controls (HC) were enrolled. ODEVs were enriched from serum by a double step immunoaffinity method using an anti OMGp (oligodendrocyte myelin glycoprotein) antibody. P2X7R concentration was measured in ODEVs lysates by ELISA.One–way Anova test showed that P2X7R in ODEVs is significantly higher in PP-MS (mean: 1742.89 pg/mL) compared both to RR-MS (mean: 1277.33 pg/mL) (p

Published
2024
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50. Disentangling the deforestation-environmental crime nexus in Latin America

Author

Nicola Clerici, Christina Staudhammer, and Francisco J. Escobedo

Subjects
Governance, Social-ecological systems, Environmental defenders, Natural resource extraction, Environmental crime Kuznets curve, Forestry, SD1-669.5, Plant ecology, QK900-989
Abstract

Deforestation and natural resource extraction are well-known threats to biodiversity conservation, environmental justice, livelihoods, ecosystem services and can even result in crimes to, and harassment of, environmental defenders. Such punitive actions against environmental defenders can influence both economic development and forest conservation efforts. Yet, little is known about this nexus and the complex relationships between environmental impacts, such as deforestation, and environmental crimes across space and time in many regions such as Latin America. We explored these complex relationships using a database of environmental crimes, threats, and harassment (ECTH) affecting environmental defenders, as well as forest loss data, and municipal-level socioeconomic indicators for nine Latin American countries over a period of eleven years. We found that as deforestation increased, there was a large increase in ECTH episodes related to agricultural activity, while in highly populated municipalities there were more ECTH episodes related to energy production, transportation, and urbanization activities. Overall, the percentage of annual deforestation had a strong influence, which varied according to municipal wealth, population density (PD), and geographical context. Statistically significant increases in violent crimes were found with increasing deforestation, but only in Honduras, Guatemala, and Mexico, and in municipalities with lower population densities. Conversely, higher income, more populated municipalities were characterized by judicial harassment, as opposed to violent crimes, indicating a type of Environmental Crime Kuznets Curve relationship. A structural equation model where deforestation was driven by the number of ECTHs, as well as percent forest area, PD, latitude, and country showed that the number of ECTH events and country were significant drivers of deforestation. Understanding these complex social-ecological dynamics shows the profound effects that deforestation and unsustainable, and unjust, environmental impacts and conflicts can have across forests and ecosystems of the Global South in terms of social justice and conservation, and thus merits increased protection of environmental defenders in Latin America.

Published
2024
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