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2. Bipolar Disorder: Identity, Social Support, Religiosity and Spirituality. Can Religiosity/Spirituality be a Mood Balancing Factor? An Italian Case Report

Author

Santambrogio, Jacopo, Maissen, Jessica, Calini, Cosima, Filippo, Maria Cristina, Frigerio, Roberto, Rampin, Roberto, Locorotondo, Giovanna, Pontiggia, Adriana, Riboldi, Stefania, Chiorazzo, Rossella, Amatulli, Antonio, De Berardis, Domenico, Clerici, Massimo, Milani, Simona, and Cavalleri, Pietro Riccardo

Published
2024
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3. The rapid antidepressant effectiveness of repeated dose of intravenous ketamine and intranasal esketamine: A post-hoc analysis of pooled real-world data

Author

d'Andrea, Giacomo, Pettorruso, Mauro, Di Lorenzo, Giorgio, Rhee, Taeho Greg, Chiappini, Stefania, Carullo, Rosalba, Barlati, Stefano, Zanardi, Raffaella, Rosso, Gianluca, Di Nicola, Marco, Andriola, Ileana, Marcatili, Matteo, Clerici, Massimo, Dell'Osso, Bernardo Maria, Sensi, Stefano L., Mansur, Rodrigo B., Rosenblat, Joshua D., Martinotti, Giovanni, and McIntyre, Roger S.

Published
2024
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7. Investigating the Effectiveness and Tolerability of Intranasal Esketamine Among Older Adults With Treatment-Resistant Depression (TRD): A Post-hoc Analysis from the REAL-ESK Study Group

Author

d'Andrea, Giacomo, Chiappini, Stefania, McIntyre, Roger S., Stefanelli, Giulia, Carullo, Rosalba, Andriola, Ileana, Zanardi, Raffaella, Martiadis, Vassilis, Sensi, Stefano L., Sani, Gabriele, Clerici, Massimo, Di Lorenzo, Giorgio, Vita, Antonio, Pettorruso, Mauro, and Martinotti, Giovanni

Published
2023
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8. Predicting outcome with Intranasal Esketamine treatment: A machine-learning, three-month study in Treatment-Resistant Depression (ESK-LEARNING)

Author

Pettorruso, Mauro, Guidotti, Roberto, d'Andrea, Giacomo, De Risio, Luisa, D'Andrea, Antea, Chiappini, Stefania, Carullo, Rosalba, Barlati, Stefano, Zanardi, Raffaella, Rosso, Gianluca, De Filippis, Sergio, Di Nicola, Marco, Andriola, Ileana, Marcatili, Matteo, Nicolò, Giuseppe, Martiadis, Vassilis, Bassetti, Roberta, Nucifora, Domenica, De Fazio, Pasquale, Rosenblat, Joshua D., Clerici, Massimo, Maria Dell'Osso, Bernardo, Vita, Antonio, Marzetti, Laura, Sensi, Stefano L., Di Lorenzo, Giorgio, McIntyre, Roger S., and Martinotti, Giovanni

Published
2023
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9. Virtual Reality to Support Healthcare Workers in Managing Stress and Anxiety During the COVID-19 Pandemic: An Online Survey

Author

Pallavicini, Federica, Orena, Eleonora, Achille, Federica, Stefanini, Stefano, Caragnano, Chiara, Vuolato, Costanza, Pepe, Alessandro, Ranieri, Paolo, di Santo, Simona, Greci, Luca, Fascendini, Sara, Defanti, Alberto, Clerici, Massimo, Mantovani, Fabrizia, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Chen, Jessie Y. C., editor, Fragomeni, Gino, editor, Degen, Helmut, editor, and Ntoa, Stavroula, editor

Published
2022
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10. Real-world experience of esketamine use to manage treatment-resistant depression: A multicentric study on safety and effectiveness (REAL-ESK study)

Author

Martinotti, Giovanni, Vita, Antonio, Fagiolini, Andrea, Maina, Giuseppe, Bertolino, Alessandro, Dell'Osso, Bernardo, Siracusano, Alberto, Clerici, Massimo, Bellomo, Antonello, Sani, Gabriele, d'Andrea, Giacomo, Chiaie, Roberto Delle, Conca, Andreas, Barlati, Stefano, Di Lorenzo, Giorgio, De Fazio, Pasquale, De Filippis, Sergio, Nicolò, Giuseppe, Rosso, Gianluca, Valchera, Alessandro, Nucifora, Domenica, Di Mauro, Stefania, Bassetti, Roberta, Martiadis, Vassilis, Olivola, Miriam, Belletti, Sandro, Andriola, Ileana, Di Nicola, Marco, Pettorruso, Mauro, McIntyre, Roger S., and di Giannantonio, Massimo

Published
2022
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12. Is there an association between inflammatory/anti-oxidant markers and the presence of psychotic symptoms or severity of illness in mood and psychotic disorders? A multi-centric study on a drug-free sample

Author

Caldiroli, Alice, Capuzzi, Enrico, Barkin, Jennifer L., Grassi, Silvia, Esposito, Cecilia Maria, Auxilia, Anna Maria, Russo, Stefania, Tagliabue, Ilaria, Carnevali, Greta Silvia, Mucci, Francesco, Invernizzi, Elena, Clerici, Massimo, and Buoli, Massimiliano

Published
2022
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18. Treatment persistence with aripiprazole once monthly: a 4-year follow-up

Author

Fagiolini, Andrea, Aguglia, Eugenio, Ballerini, Andrea, Callista, Gaetano, Carpiniello, Bernardo, Clerici, Massimo, Corrivetti, Giulio, Cuomo, Alessandro, De Fazio, Pasquale, De Filippis, Sergio, De Giorgi, Serafino, Goracci, Arianna, La Barbera, Daniele, Mencacci, Claudio, Montagnani, Gino, Pigato, Giorgio, Vannucchi, Jarno, and Vita, Antonio

Published
2022
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19. A virtual reality home-based training for the management of stress and anxiety among healthcare workers during the COVID-19 pandemic: study protocol for a randomized controlled trial

Author

Pallavicini, Federica, Orena, Eleonora, di Santo, Simona, Greci, Luca, Caragnano, Chiara, Ranieri, Paolo, Vuolato, Costanza, Pepe, Alessandro, Veronese, Guido, Stefanini, Stefano, Achille, Federica, Dakanalis, Antonios, Bernardelli, Luca, Sforza, Francesca, Rossini, Angelo, Caltagirone, Carlo, Fascendini, Sara, Clerici, Massimo, Riva, Giuseppe, and Mantovani, Fabrizia

Published
2022
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20. Consequences of the COVID-19 pandemic on admissions to general hospital psychiatric wards in Italy: Reduced psychiatric hospitalizations and increased suicidality

Author

Boldrini, Tommaso, Girardi, Paolo, Clerici, Massimo, Conca, Andreas, Creati, Chiara, Di Cicilia, Giuseppe, Ducci, Giuseppe, Durbano, Federico, Maci, Carlo, Maone, Antonio, Nicolò, Giuseppe, Oasi, Osmano, Percudani, Mauro, Polselli, Gian Marco, Pompili, Maurizio, Rossi, Alessandro, Salcuni, Silvia, Tarallo, Federica, Vita, Antonio, and Lingiardi, Vittorio

Published
2021
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22. Two-Injection Start Regimen of Long-Acting Aripiprazole in 133 Patients With Schizophrenia

Author

Cuomo, Alessandro, Aguglia, Eugenio, Biagini, Stefano, Carano, Alessandro, Clerici, Massimo, DʼAgostino, Armando, De Filippis, Sergio, De Giorgi, Serafino, Goracci, Arianna, Libri, Claudia, Lombardi, Francesco, Lupi, Matteo, Maina, Giuseppe, Martinotti, Giovanni, Nigro, Pietro, Pettorruso, Mauro, Ricci, Valerio, Rossi, Eros, Russo, Felicia, Fagiolini, Andrea, Caldiroli, Alice, Capuzzi, Enrico, Carlesi, Dorotry, Cavallotti, Simone, Ceci, Franca, Chiappini, Stefania, Marcatili, Matteo, Ossola, Chiara, Ciminello, Noemi, and Casati, Giulia

Published
2023
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23. Prevalence of Co-Occurring Psychiatric Disorders in Adults and Adolescents with Intellectual Disability: A Systematic Review and Meta-Analysis

Author

Mazza, Mario G., Rossetti, Aurora, Crespi, Giovanna, and Clerici, Massimo

Abstract

Background: Subjects with intellectual disability (ID) are vulnerable to experience psychiatric disorders. The present authors performed a systematic review and meta-analysis to estimate the prevalence of co-occurring psychiatric disorders, excluding co-occurring autism spectrum disorders, in subjects with intellectual disability. Method: The present authors performed a random-effects meta-analysis of the prevalence of psychiatric disorders in adults and adolescents with intellectual disability. Results: Twenty-two studies were included. The pooled prevalence of any co-occurring psychiatric disorders in intellectual disability was 33.6% (95% CI: 25.2%-43.1%) with high heterogeneity but no publication bias. Prevalence was lower in population-based studies, in studies that used ICD criteria for the psychopathology and in studies with low risk of bias. The prevalence was higher in mild, moderate and severe intellectual disability than in profound intellectual disability. Conclusions: Psychiatric disorders are common in subjects with intellectual disability, and the present authors found that clinical and methodological moderators affect the pooled prevalence.

Published
2020
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24. The use of esketamine in comorbid treatment resistant depression and obsessive compulsive disorder following extensive pharmacogenomic testing: a case report

Author

Marcatili Matteo, Pellicioli Cristian, Maggioni Laura, Motta Federico, Redaelli Chiara, Ghelfi Lorenzo, Krivosova Michaela, Matteo Sibilla, Nava Roberto, Colmegna Fabrizia, Dakanalis Antonios, Caldiroli Alice, Capuzzi Enrico, Benatti Beatrice, Bertola Francesca, Villa Nicoletta, Piperno Alberto, Ippolito Silvia, and Clerici Massimo

Subjects
Treatment resistant depression, TRD, Obsessive–compulsive disorder, OCD, Esketamine, Ketamine, Psychiatry, RC435-571
Abstract

Abstract Background Major depressive disorder (MDD) patients not responding to two or more different antidepressant treatments are currently considered to suffer from treatment resistant depression (TRD). Recently, intranasal esketamine has been approved by both the American Food and Drug Administration and European Medicines Agency for TRD and, more recently, in moderate to severe episode of MDD, as acute short-term treatment for the rapid reduction of depressive symptoms, which, according to clinical judgement, constitute a psychiatric emergency. There is currently no indication for obsessive–compulsive disorder (OCD) although recently published studies have already shown a rapid and significant reduction of OCD-like symptoms following ketamine administration. The etiology of OCD has not yet been fully elucidated but there is a growing evidence that glutamate signaling dysfunction in the cortico-striatal–thalamo-cortical circuitry plays an essential role. This case report exemplifies possible clinical effects of esketamine on both depressive and OCD symptoms. Case presentation We present the case of a 39-year-old man suffering from TRD. During the first evaluation at our clinic, he also reported the presence of OCD spectrum symptoms, causing him to perform time-consuming mental rituals due to pathological doubts regarding the relationship with his wife as well as intrusive thoughts regarding his mental conditions. He underwent psychometric evaluations, therapeutic drug monitoring analysis, and pharmacogenomic tests. The overall results helped to explain patient’s treatment-resistance. Moreover, we observed a significant reduction in both depressive and OCD symptoms after administration of esketamine. Conclusion This case underlines the importance of pharmacogenomic tests in profiling TRD patients and confirms the possible use of esketamine in the treatment of comorbid OCD.

Published
2021
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27. ASSESSING THE FEAR OF COVID-19 IN PSYCHIATRIC PATIENTS: RESULTS FROM AN ITALIAN MULTICENTRIC STUDY.

Author

Nava, Roberto, Benatti, Beatrice, Girone, Nicolaja, Macellaro, Monica, Pellicioli, Cristian, Maggioni, Laura, Marcatili, Matteo, Dell'Osso, Bernardo, and Clerici, Massimo

Subjects
POST-acute COVID-19 syndrome, COVID-19 pandemic, PEOPLE with mental illness, MENTAL illness, COVID-19
Abstract

Objective: Even though the COVID-19 emergency has concluded, its consequences are still relevant. Recent evidence suggests that a significant proportion of individuals experience persistent symptoms long after the initial infection has resolved, classified as "Long COVID" condition. Fear of COVID-19 increases anxiety and stress levels in healthy individuals and exacerbates the symptoms of those with pre-existing psychiatric disorders; therefore understanding the impact of the pandemic on psychiatric disorders remains of utmost importance. The present study aimed at assessing the prevalence and predictive factors of fear of COVID-19 in a sample of patients with different psychiatric conditions. Method: A sample of 269 psychiatric patients were recruited from two different tertiary clinics in Italy and assessed with the Fear of COVID-19 Scale (FCV-19S). In order to compare patients with a significant fear of COVID-19 or without (Fear+ vs. Fear-) and to identify the main features in terms of clinical dimension, exploratory and predictive analysis were performed. Results. Female gender, age at illness onset, and insight levels emerged as positive predictors of FCV-19S. Conversely, current substance abuse emerged as a negative predictor of fear levels. Moreover, significantly lower FCV-19S scores were observed in patients with a diagnosis of schizophrenia spectrum disorders. Conclusions. Specific sociodemographic and clinical factors predicted higher levels of fear of COVID-19 in psychiatric patients. Further studies are warranted to determine the potential long-term consequences of the COVID-19 impact on mental health. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Perspective on the role of pharmacogenetic testing in mental health care in Slovakia.

Author

KRIVOSOVA, Michaela, HUTKA, Peter, KUSNIEROVA, Sara, MACEKOVA, Zuzana, MAGGIONI, Laura, MARCATILI, Matteo, CLERICI, Massimo, and MOKRY, Juraj

Subjects
MENTAL health services, DRUG side effects, DRUG therapy, MEDICAL personnel, MENTAL illness
Abstract

BACKGROUND: The pathophysiology of mental illnesses is not fully understood, leading to insufficient remission, frequent adverse drug reactions, and treatment resistance. Pharmacogenetic (PGx) testing, a personalized approach recently adopted also in psychiatry, can guide effective drug therapy and minimize side effects. The objective of this study was to determine the perspective of Slovak clinicians regarding the integration of PGx testing in psychiatric clinical practice. METHODS: Questionnaires covering various aspects such as prior experience with PGx testing, self-perceived competence, perceived utility, potential risks and challenges were distributed directly to attendees at two psychiatric conferences held in Slovakia in 2023 and their responses were statistically analysed. RESULTS: Out of 54 respondents, only 7.4% had previous experience with PGx in clinical practice. The most clinicians felt that they should possess the skills to apply PGx testing in psychiatric clinical practice and were enthusiastic about increasing their expertise. They found PGx useful in medication selection, adverse effect management, and treatment-resistant depression. The primary concerns centered around the lack of welldefined guidelines and the financial considerations linked to the testing. CONCLUSIONS: Considering the participants' interest in PGx and its integration into clinical practice, educational programmes based on recommendations, guidelines, and convincing evidence could be organized. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Influence of post-migration living difficulties on mental health among refugees and asylum seekers: A scoping-review on clinical tools.

Author

Santambrogio, Jacopo, Cimminiello, Noemi, Wisidagamage Don, Prasad, Leon, Elisabetta, Miragliotta, Elena, Capuzzi, Enrico, Colmegna, Fabrizia, and Clerici, Massimo

Subjects
MENTAL illness risk factors, EMIGRATION & immigration & psychology, RISK assessment, MEDICAL information storage & retrieval systems, POST-traumatic stress disorder, SOMATOFORM disorders, HEALTH services accessibility, PSYCHOLOGICAL distress, WORRY, FAMILY conflict, LEGAL procedure, PSYCHOLOGY of refugees, QUESTIONNAIRES, UNEMPLOYMENT, ANXIETY, WAR, VIOLENCE in the workplace, SYSTEMATIC reviews, MEDLINE, MIGRANT labor, SOCIAL adjustment, SOCIAL support, ONLINE information services, DISCRIMINATION (Sociology), PSYCHOSOCIAL factors, MENTAL depression, SLEEP disorders, POVERTY, CULTURAL pluralism
Abstract

Background: The literature indicates an increasing interest in the mental health of refugees (R) and asylum seekers (AS) – particularly how it could be affected by previous exposure to trauma and violence – but less has been written about the issues they are forced to face during the post-migration period and how these also can affect mental health. Research shows that the mental health of R/AS is highly influenced by their post-migration conditions and may deteriorate due to post-migration social health-related determinants; in addition, a lack of language skills, discrimination, separation from family, poverty, and other stressors can contribute to social isolation. The difficulty in asking for help in case of psychological distress and, consequently, in accessing care, contributes to the worsening of their clinical condition. Aims: The primary purpose of this study is to identify and provide a review of the clinical tools used to screen migrants (R/AS) at risk of developing psychological distress, identifying post-migration difficulties. Methods: We searched studies in PubMed, Embase, Scopus, Cochrane (Central), and Cinahl (ultimate) with the last search on 14 April 2023, using a combination of keywords and Medical Subject Headings (MeSH). Results: Our systematic search identified 1,878 records. After removing duplicates, we screened 1,238 records by title and abstract, retaining 97 for full text review. Of these, 68 met full eligibility criteria (1995–2023). A total of 30 social scales have been identified, as well as structured or semi-structured questionnaires and interviews. Translated into multiple languages, the tools can be self-administered or administered by trained professionals. PMLD is known for its effectiveness in evaluating the post-migration period and predicting mental health issues. Conclusions: Considering the limited number of studies and, consequently, the limited number of tools found, it can be inferred that not enough attention is given to post-migration in the broader sense. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Clinical Factors Associated with Binge-Eating Episodes or Purging Behaviors in Patients Affected by Eating Disorders: A Cross-Sectional Study

Author

Caldiroli, Alice, primary, Affaticati, Letizia Maria, additional, Coloccini, Sara, additional, Manzo, Francesca, additional, Scalia, Alberto, additional, Capuzzi, Enrico, additional, La Tegola, Davide, additional, Colmegna, Fabrizia, additional, Dakanalis, Antonios, additional, Signorelli, Maria Salvina, additional, Buoli, Massimiliano, additional, and Clerici, Massimo, additional

Published
2024
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37. Multilingualism and international mental health research–The barriers for non-native speakers of English

Author

de Girolamo, Giovanni, primary, Calza, Stefano, additional, Clerici, Massimo, additional, D’Agostino, Armando, additional, De Ronchi, Diana, additional, Fagiolini, Andrea, additional, Nicolò, Giuseppe, additional, Nobile, Maria, additional, Raballo, Andrea, additional, Rucci, Paola, additional, Serretti, Alessandro, additional, Starace, Fabrizio, additional, Tiraboschi, Pietro, additional, and Brambilla, Paolo, additional

Published
2024
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38. Which Factors Are Associated With Comorbid Psychiatric Conditions in Patients Affected by Substance Use Disorders? The Impact of COVID-19 Pandemic on Dual-Diagnosis Subjects

Author

Tagliabue, Ilaria, primary, Caldiroli, Alice, additional, Capuzzi, Enrico, additional, Borgonovo, Riccardo, additional, Scalia, Alberto, additional, Ferrè, Alessandro, additional, Sibilla, Matteo, additional, Turco, Marco, additional, Affaticati, Letizia M., additional, Crespi, Giovanna, additional, Galimberti, Giovanni, additional, Dakanalis, Antonios, additional, Colmegna, Fabrizia, additional, Buoli, Massimiliano, additional, and Clerici, Massimo, additional

Published
2024
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49. Which sociodemographic and clinical characteristics are associated with recurrent incarcerations in adult male people who are incarcerated? A cross-sectional study

Author

Capuzzi, Enrico, primary, Caldiroli, Alice, additional, Auxilia, Anna Maria, additional, Capellazzi, Martina, additional, Tagliabue, Ilaria, additional, Manzoni, Arianna, additional, Cova, Francesca, additional, Di Brita, Carmen, additional, Surace, Teresa, additional, Bilardo, Stefania, additional, Rubelli, Paola, additional, Truisi, Emanuele, additional, Di Valentin, Matteo, additional, Buoli, Massimiliano, additional, and Clerici, Massimo, additional

Published
2024
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