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15 results on '"Clifford, Alison H."'

5. Does 18F-Fluodordeoxyglucose Positron Emission Tomography (PET) Correlate with Disease Activity in Patients who are Receiving Treatment for Giant Cell Arteritis (GCA): a Systematic Review and Meta-Analysis

Author

Clifford, Alison H.

Abstract

Introduction: The utility of obtaining follow up 18-F fluorodeoxyglucose positron emission tomography (FDG PET) imaging in patients with giant cell arteritis (GCA) is unclear. We performed a systematic review and meta-analysis to determine how often vascular FDG PET uptake improves or normalizes in GCA patients after starting immunosuppressive treatment. Methods: An electronic literature search of MEDLINE (Ovid), EMBASE, CINAHL, Scopus, and Cochrane Library from inception through November 4 2020 was performed. Longitudinal studies assessing the correlation of follow-up 18F-FDG PET and clinical or biochemical disease activity in GCA patients receiving treatment were included. Screening, full text review and data extraction was performed by 2 independent reviewers. Meta-analysis of the pooled sensitivity of improved PET for those with clinical or biochemical improvement, and normalized PET for those in clinical remission was performed. Subgroup analyses were performed to examine the tocilizumab-treated patients (TCZ subgroup), studies using international consensus criteria for PET interpretation (CC subgroup), as well as use of hybrid PET/CT (PET/CT subgroup) imaging, and effects of size (Pt Number subgroup). Results: Of 18 included studies, most described improvement of FDG uptake in GCA patients after starting immunosuppressive treatment, but normalization of PET occurred less commonly among patients in remission. The pooled sensitivity of improved PET uptake for those with clinical improvement was 0.85 (95% CI 0.76-0.93, I2=0), the pooled sensitivity of improved PET uptake for those with biochemical improvement was 0.84, (95% CI 0.74-0.93, I2=0), and the iii pooled sensitivity for normalized PET in those in clinical remission was 0.43 (95% CI 0.34-0.53, I2=9.2). Results were similar in the CC , PET/CT and Pt Number subgroups (pooled sensitivity for PET normalization was 0. 41, 95% CI 0.28, 0.55; 0.43, 95% CI 0.32, 0.55; and 0.41, 95% CI 0.33, 0.51), however more heterogeneity was observed (I2=50.3%, 92.5%, and 95.3% respectively.) The pooled sensitivity for PET normalization improved to 0.80 (95% CI 0.65-0.93, I2=0) in the TCZ subgroup. Conclusion: Vascular FDG uptake improved in the majority (85%) of GCA patients who experienced clinical improvement on treatment and normalized in 43%. Limited data suggested follow up PET scans normalized more often in TCZ-treated patients. Additional prospective longitudinal studies of FDG PET are needed.

Published
2023
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6. CanVasc Consensus Recommendations for the Management of Antineutrophil Cytoplasm Antibody-associated Vasculitis: 2020 Update

Author

Mendel, Arielle, primary, Ennis, Daniel, additional, Go, Ellen, additional, Bakowsky, Volodko, additional, Baldwin, Corisande, additional, Benseler, Susanne M., additional, Cabral, David A., additional, Carette, Simon, additional, Clements-Baker, Marie, additional, Clifford, Alison H., additional, Cohen Tervaert, Jan Willem, additional, Cox, Gerard, additional, Dehghan, Natasha, additional, Dipchand, Christine, additional, Dhindsa, Navjot, additional, Famorca, Leilani, additional, Fifi-Mah, Aurore, additional, Garner, Stephanie, additional, Girard, Louis-Philippe, additional, Lessard, Clode, additional, Liang, Patrick, additional, Noone, Damien, additional, Makhzoum, Jean-Paul, additional, Milman, Nataliya, additional, Pineau, Christian A., additional, Reich, Heather N., additional, Rhéaume, Maxime, additional, Robinson, David B., additional, Rumsey, Dax G., additional, Towheed, Tanveer E., additional, Trudeau, Judith, additional, Twilt, Marinka, additional, Yacyshyn, Elaine, additional, Yeung, Rae S.M., additional, Barra, Lillian B., additional, Khalidi, Nader, additional, and Pagnoux, Christian, additional

Published
2020
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7. Outcomes Among 196 Patients With Noninfectious Proximal Aortitis

Author

Clifford, Alison H., primary, Arafat, Amr, additional, Idrees, Jay J., additional, Roselli, Eric E., additional, Tan, Carmela D., additional, Rodriguez, E. Rene, additional, Svensson, Lars G., additional, Blackstone, Eugene, additional, Johnston, Douglas, additional, Pettersson, Gosta, additional, Soltesz, Edward, additional, and Hoffman, Gary S., additional

Published
2019
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8. Microbiomes of Inflammatory Thoracic Aortic Aneurysms Due to Giant Cell Arteritis and Clinically Isolated Aortitis Differ From Those of Non-Inflammatory Aneurysms

Author

Getz, Ted M., primary, Hoffman, Gary Stuart, additional, Padmanabhan, Roshan, additional, Villa-Forte, Alexandra, additional, Roselli, Eric E., additional, Blackstone, Eugene, additional, Johnston, Douglas, additional, Pettersson, Gosta, additional, Soltesz, Edward, additional, Svensson, Lars G., additional, Calabrese, Leonard H., additional, Clifford, Alison H., additional, and Eng, Charis, additional

Published
2019
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9. 184. THE MICROBIOME OF TEMPORAL ARTERIES

Author

Hoffman, Gary S, primary, Getz, Ted M, additional, Padmanabhan, Roshan, additional, Villa-Forte, Alexandra, additional, Calabrese, Leonard H, additional, Clifford, Alison H, additional, Funchain, Pauline, additional, Sankhunny, Madhav, additional, Perry, Julian D, additional, Blandford, Alexander, additional, Kosmorsky, Gregory, additional, Lystad, Lisa, additional, and Eng, Charis, additional

Published
2019
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10. 183. MICROBIOME IN AORTITIS

Author

Getz, Ted M, primary, Hoffman, Gary S, additional, Padmanabhan, Roshan, additional, Villa-Forte, Alexandra, additional, Roselli, Eric E, additional, Blackstone, Eugene, additional, Johnston, Douglas, additional, Pettersson, Gosta, additional, Soltesz, Edward, additional, Svensson, Lars G, additional, Calabrese, Leonard H, additional, Clifford, Alison H, additional, and Eng, Charis, additional

Published
2019
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11. The Microbiome of Temporal Arteries

Author

Hoffman, Gary Stuart, primary, Getz, Ted M., additional, Padmanabhan, Roshan, additional, Villa-Forte, Alexandra, additional, Clifford, Alison H., additional, Funchain, Pauline, additional, Sankunny, Madhav, additional, Perry, Julian D., additional, Blandford, Alexander, additional, Kosmorsky, Gregory, additional, Lystad, Lisa, additional, Calabrese, Leonard H., additional, and Eng, Charis, additional

Published
2019
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12. CanVasc Consensus Recommendations for the Management of Antineutrophil Cytoplasm Antibody-associated Vasculitis: 2020 Update.

Author

Mendel, Arielle, Ennis, Daniel, Go, Ellen, Bakowsky, Volodko, Baldwin, Corisande, Benseler, Susanne M., Cabral, David A., Carette, Simon, Clements-Baker, Marie, Clifford, Alison H., Tervaert, Jan Willem Cohen, Cox, Gerard, Dehghan, Natasha, Dipchand, Christine, Dhindsa, Navjot, Famorca, Leilani, Fifi-Mah, Aurore, Garner, Stephanie, Girard, Louis-Philippe, and Lessard, Clode

Published
2021
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14. Positron Emission Tomography/Computerized Tomography in Newly Diagnosed Patients with Giant Cell Arteritis Who Are Taking Glucocorticoids

Author

Clifford, Alison H., primary, Murphy, Elana M., additional, Burrell, Steven C., additional, Bligh, Mathew P., additional, MacDougall, Ryan F., additional, Heathcote, J. Godfrey, additional, Castonguay, Mathieu C., additional, Lee, Min S., additional, Matheson, Kara, additional, and Hanly, John G., additional

Published
2017
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15. Incidentally detected noninfectious thoracic aortitis: A clinical approach.

Author

Clifford AH

Subjects
Humans, Aortitis diagnosis, Incidental Findings, Aorta, Thoracic diagnostic imaging
Abstract

Noninfectious aortitis is occasionally detected incidentally, either on imaging or on histopathologic review after open thoracic aortic surgery. It can present as a clinically asymptomatic, seemingly focal lesion, as diffuse inflammation throughout several aortic segments but sparing the branch vessels, or as a manifestation of a widespread systemic condition. Treatment differs based on etiology, so once identified, all patients with aortitis need a thorough evaluation, laboratory tests, complete large-vessel imaging, and a referral to a vasculitis expert. All patients with aortitis are at high risk of future vascular complications and should be followed with serial clinical evaluations and imaging., (Copyright © 2024 The Cleveland Clinic Foundation. All Rights Reserved.)

Published
2024
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