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2. Local primordial non-Gaussianity from the large-scale clustering of photometric DESI luminous red galaxies

Author

Rezaie, Mehdi, Ross, Ashley J., Seo, Hee-Jong, Kong, Hui, Porredon, Anna, Samushia, Lado, Chaussidon, Edmond, Krolewski, Alex, de Mattia, Arnaud, Beutler, Florian, Aguilar, Jessica Nicole, Ahlen, Steven, Alam, Shadab, Avila, Santiago, Bahr-Kalus, Benedict, Bermejo-Climent, Jose, Brooks, David, Claybaugh, Todd, Cole, Shaun, Dawson, Kyle, de la Macorra, Axel, Doel, Peter, Font-Ribera, Andreu, Forero-Romero, Jaime E., Gontcho, Satya Gontcho A, Guy, Julien, Honscheid, Klaus, Huterer, Dragan, Kisner, Theodore, Landriau, Martin, Levi, Michael, Manera, Marc, Meisner, Aaron, Miquel, Ramon, Mueller, Eva-Maria, Myers, Adam, Newman, Jeffrey A., Nie, Jundan, Palanque-Delabrouille, Nathalie, Percival, Will, Poppett, Claire, Rossi, Graziano, Sanchez, Eusebio, Schubnell, Michael, Tarlé, Gregory, Weaver, Benjamin Alan, Yèche, Christophe, Zhou, Zhimin, and Zou, Hu

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Computer Science - Machine Learning, Physics - Computational Physics, Physics - Data Analysis, Statistics and Probability
Abstract

We use angular clustering of luminous red galaxies from the Dark Energy Spectroscopic Instrument (DESI) imaging surveys to constrain the local primordial non-Gaussianity parameter $\fnl$. Our sample comprises over 12 million targets, covering 14,000 square degrees of the sky, with redshifts in the range $0.2< z < 1.35$. We identify Galactic extinction, survey depth, and astronomical seeing as the primary sources of systematic error, and employ linear regression and artificial neural networks to alleviate non-cosmological excess clustering on large scales. Our methods are tested against simulations with and without $\fnl$ and systematics, showing superior performance of the neural network treatment. The neural network with a set of nine imaging property maps passes our systematic null test criteria, and is chosen as the fiducial treatment. Assuming the universality relation, we find $\fnl = 34^{+24(+50)}_{-44(-73)}$ at 68\%(95\%) confidence. We apply a series of robustness tests (e.g., cuts on imaging, declination, or scales used) that show consistency in the obtained constraints. We study how the regression method biases the measured angular power-spectrum and degrades the $\fnl$ constraining power. The use of the nine maps more than doubles the uncertainty compared to using only the three primary maps in the regression. Our results thus motivate the development of more efficient methods that avoid over-correction, protect large-scale clustering information, and preserve constraining power. Additionally, our results encourage further studies of $\fnl$ with DESI spectroscopic samples, where the inclusion of 3D clustering modes should help separate imaging systematics and lessen the degradation in the $\fnl$ uncertainty., Comment: 21 pages, 17 figures, 7 tables (Appendix excluded). Published in MNRAS

Published
2023
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3. Cosmological parameter forecasts by a joint 2D tomographic approach to CMB and galaxy clustering

Author

Bermejo-Climent, José R., Ballardini, Mario, Finelli, Fabio, Paoletti, Daniela, Maartens, Roy, Rubiño-Martin, José A., and Valenziano, Luca

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The cross-correlation between the cosmic microwave background (CMB) fields and matter tracers carries important cosmological information. In this paper, we forecast by a signal-to-noise ratio analysis the information contained in the cross-correlation of the CMB anisotropy fields with source counts for future cosmological observations and its impact on cosmological parameters uncertainties, using a joint tomographic analysis. We include temperature, polarization and lensing for the CMB fields and galaxy number counts for the matter tracers. By restricting ourselves to quasi-linear scales, we forecast by a Fisher matrix formalism the relative importance of the cross-correlation of source counts with the CMB in the constraints on the parameters for several cosmological models. We obtain that the CMB-number counts cross-correlation can improve the dark energy Figure of Merit (FoM) at most up to a factor $\sim 2$ for LiteBIRD+CMB-S4 $\times$ SKA1 compared to the uncorrelated combination of both probes and will enable the Euclid-like photometric survey to reach the highest FoM among those considered here. We also forecast how CMB-galaxy clustering cross-correlation could increase the FoM of the neutrino sector, also enabling a statistically significant ($\gtrsim$ 3$\sigma$ for LiteBIRD+CMB-S4 $\times$ SPHEREx) detection of the minimal neutrino mass allowed in a normal hierarchy by using quasi-linear scales only. Analogously, we find that the uncertainty in the local primordial non-Gaussianity could be as low as $\sigma (f_{\rm NL}) \sim 1.5-2$ by using two-point statistics only with the combination of CMB and radio surveys such as EMU and SKA1. Our results highlight the additional constraining power of the cross-correlation between CMB and galaxy clustering from future surveys which is mainly based on quasi-linear scales and therefore sufficiently robust to non-linear effects., Comment: 30 pages, 13 figures, 10 tables

Published
2021
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5. Microwave spectro-polarimetry of matter and radiation across space and time

Author

Delabrouille, Jacques, Abitbol, Maximilian H, Aghanim, Nabila, Ali-Haïmoud, Yacine, Alonso, David, Alvarez, Marcelo, Banday, Anthony J, Bartlett, James G, Baselmans, Jochem, Basu, Kaustuv, Battaglia, Nicholas, Climent, José Ramón Bermejo, Bernal, José L, Béthermin, Matthieu, Bolliet, Boris, Bonato, Matteo, Bouchet, François R, Breysse, Patrick C, Burigana, Carlo, Cai, Zhen-Yi, Chluba, Jens, Churazov, Eugene, Dannerbauer, Helmut, De Bernardis, Paolo, De Zotti, Gianfranco, Di Valentino, Eleonora, Dimastrogiovanni, Emanuela, Endo, Akira, Erler, Jens, Ferraro, Simone, Finelli, Fabio, Fixsen, Dale, Hanany, Shaul, Hart, Luke, Hernández-Monteagudo, Carlos, Hill, J Colin, Hotinli, Selim C, Karatsu, Kenichi, Karkare, Kirit, Keating, Garrett K, Khabibullin, Ildar, Kogut, Alan, Kohri, Kazunori, Kovetz, Ely D, Lagache, Guilaine, Lesgourgues, Julien, Madhavacheril, Mathew, Maffei, Bruno, Mandolesi, Nazzareno, Martins, Carlos, Masi, Silvia, Mather, John, Melin, Jean-Baptiste, Dizgah, Azadeh Moradinezhad, Mroczkowski, Tony, Mukherjee, Suvodip, Nagai, Daisuke, Negrello, Mattia, Palanque-Delabrouille, Nathalie, Paoletti, Daniela, Patil, Subodh P, Piacentini, Francesco, Raghunathan, Srinivasan, Ravenni, Andrea, Remazeilles, Mathieu, Revéret, Vincent, Rodriguez, Louis, Rotti, Aditya, Martin, Jose-Alberto Rubiño, Sayers, Jack, Scott, Douglas, Silk, Joseph, Silva, Marta, Souradeep, Tarun, Sugiyama, Naonori, Sunyaev, Rashid, Switzer, Eric R, Tartari, Andrea, Trombetti, Tiziana, and Zubeldia, Íñigo

Subjects
Cosmology, Early Universe, Galaxies, Galaxy clusters, Astronomical and Space Sciences, Astronomy & Astrophysics
Abstract

This paper discusses the science case for a sensitive spectro-polarimetric survey of the microwave sky. Such a survey would provide a tomographic and dynamic census of the three-dimensional distribution of hot gas, velocity flows, early metals, dust, and mass distribution in the entire Hubble volume, exploit CMB temperature and polarisation anisotropies down to fundamental limits, and track energy injection and absorption into the radiation background across cosmic times by measuring spectral distortions of the CMB blackbody emission. In addition to its exceptional capability for cosmology and fundamental physics, such a survey would provide an unprecedented view of microwave emissions at sub-arcminute to few-arcminute angular resolution in hundreds of frequency channels, a data set that would be of immense legacy value for many branches of astrophysics. We propose that this survey be carried out with a large space mission featuring a broad-band polarised imager and a moderate resolution spectro-imager at the focus of a 3.5 m aperture telescope actively cooled to about 8K, complemented with absolutely-calibrated Fourier Transform Spectrometer modules observing at degree-scale angular resolution in the 10–2000 GHz frequency range. We propose two observing modes: a survey mode to map the entire sky as well as a few selected wide fields, and an observatory mode for deeper observations of regions of specific interest.

Published
2021

6. Measuring lensing ratios with future cosmological surveys

Author

Bermejo-Climent, José Ramón, Ballardini, Mario, Finelli, Fabio, and Cardone, Vincenzo Fabrizio

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The ratio between the CMB lensing/galaxy counts and the galaxy shear/galaxy counts cross-correlations combines the information from different cosmological probes to infer cosmographic measurements that are less dependent on astrophysical uncertainties and can constrain the geometry of the Universe. We discuss the future perspectives for the measurement of this lensing ratio as previously introduced, i.e. with the use of the Limber and flat-sky approximations and neglecting all the effects on the galaxy survey from observing on the past lightcone. We then show how the cosmological information in this estimator is affected by the Limber approximation and by the inclusion of the redshift space distorsions (RSD) and magnification lensing contributions to the galaxy number counts. We find that the magnification lensing contribution induces a multipole dependence of the lensing ratio that we show to be detectable at a statistical significant level combining post-$Planck$ CMB surveys and a Euclid-like experiment. We propose an improved estimator which takes into account this angular scale dependence. Using this extended formalism, we present forecasts for upcoming and future cosmological surveys and we show at which extent the lensing ratio information can improve the CMB constraints on cosmological parameters. We get that for extended cosmological models where the neutrino mass, the spatial curvature and the dark energy equation of state are allowed to vary, the constraints from $Planck$ on these parameters and on $H_0$ can be reduced by $\sim 40\%$ with the inclusion of a single lensing ratio and by $\sim 60-70\%$ adding the joint measurement of 9 lensing ratios with a Euclid-like survey. We also find that neglegcting the contribution from magnification lensing can induce a bias on the derived cosmological parameters in a combined analysis., Comment: 15 pages, 12 figures, 1 table, accepted for publication in PRD

Published
2019
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7. Microwave Spectro-Polarimetry of Matter and Radiation across Space and Time

Author

Delabrouille, Jacques, Abitbol, Maximilian H., Aghanim, Nabila, Ali-Haimoud, Yacine, Alonso, David, Alvarez, Marcelo, Banday, Anthony J., Bartlett, James G., Baselmans, Jochem, Basu, Kaustuv, Battaglia, Nicholas, Climent, Jose Ramon Bermejo, Bernal, Jose L., Béthermin, Matthieu, Bolliet, Boris, Bonato, Matteo, Bouchet, François R., Breysse, Patrick C., Burigana, Carlo, Cai, Zhen-Yi, Chluba, Jens, Churazov, Eugene, Dannerbauer, Helmut, De Bernardis, Paolo, De Zotti, Gianfranco, Di Valentino, Eleonora, Dimastrogiovanni, Emanuela, Endo, Akira, Erler, Jens, Ferraro, Simone, Finelli, Fabio, Fixsen, Dale, Hanany, Shaul, Hart, Luke, Hernandez-Monteagudo, Carlos, Hill, J. Colin, Hotinli, Selim C., Karatsu, Kenichi, Karkare, Kirit, Keating, Garrett K., Khabibullin, Ildar, Kogut, Alan, Kohri, Kazunori, Kovetz, Ely D., Lagache, Guilaine, Lesgourgues, Julien, Madhavacheril, Mathew, Maffei, Bruno, Mandolesi, Nazzareno, Martins, Carlos, Masi, Silvia, Mather, John, Melin, Jean-Baptiste, Dizgah, Azadeh Moradinezhad, Mroczkowski, Tony, Mukherjee, Suvodip, Nagai, Daisuke, Negrello, Mattia, Palanque-Delabrouille, Nathalie, Paoletti, Daniela, Patil, Subodh P., Piacentini, Francesco, Raghunathan, Srinivasan, Ravenni, Andrea, Remazeilles, Mathieu, Revéret, Vincent, Rodriguez, Louis, Rotti, Aditya, Martin, Jose-Alberto Rubino, Sayers, Jack, Scott, Douglas, Silk, Joseph, Silva, Marta, Souradeep, Tarun, Sugiyama, Naonori, Sunyaev, Rashid, Switzer, Eric R., Tartari, Andrea, Trombetti, Tiziana, and Zubeldia, Inigo

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, Astrophysics - Instrumentation and Methods for Astrophysics, General Relativity and Quantum Cosmology
Abstract

This paper discusses the science case for a sensitive spectro-polarimetric survey of the microwave sky. Such a survey would provide a tomographic and dynamic census of the three-dimensional distribution of hot gas, velocity flows, early metals, dust, and mass distribution in the entire Hubble volume, exploit CMB temperature and polarisation anisotropies down to fundamental limits, and track energy injection and absorption into the radiation background across cosmic times by measuring spectral distortions of the CMB blackbody emission. In addition to its exceptional capability for cosmology and fundamental physics, such a survey would provide an unprecedented view of microwave emissions at sub-arcminute to few-arcminute angular resolution in hundreds of frequency channels, a data set that would be of immense legacy value for many branches of astrophysics. We propose that this survey be carried-out with a large space mission featuring a broad-band polarised imager and a moderate resolution spectro-imager at the focus of a 3.5m aperture telescope actively cooled to about 8K, complemented with absolutely-calibrated Fourier Transform Spectrometer modules observing at degree-scale angular resolution in the 10-2000 GHz frequency range. We propose two observing modes: a survey mode to map the entire sky as well as a few selected wide fields, and an observatory mode for deeper observations of regions of specific interest., Comment: 20 pages, white paper submitted in answer to the "Voyage 2050" call to prepare the long term plan in the ESA science programme

Published
2019

8. Targeting the immune microenvironment in Waldenström macroglobulinemia via halting the CD40/CD40-ligand axis

Author

Sacco, Antonio, Desantis, Vanessa, Celay, Jon, Giustini, Viviana, Rigali, Fabio, Savino, Francesco D., Cea, Michele, Soncini, Debora, Cagnetta, Antonia, Solimando, Antonio G., D’Aliberti, Deborah, Spinelli, Silvia, Ramazzotti, Daniele, Almici, Camillo, Todoerti, Katia, Neri, Antonino, Anastasia, Antonella, Tucci, Alessandra, Motta, Marina, Chiarini, Marco, Kawano, Yawara, Martinez-Climent, Jose A., Piazza, Rocco, and Roccaro, Aldo M.

Published
2023
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9. Activation of the PP2A-B56α heterocomplex synergizes with venetoclax therapies in AML through BCL2 and MCL1 modulation

Author

Peris, Irene, Romero-Murillo, Silvia, Martínez-Balsalobre, Elena, Farrington, Caroline C., Arriazu, Elena, Marcotegui, Nerea, Jiménez-Muñoz, Marta, Alburquerque-Prieto, Cristina, Torres-López, Andrea, Fresquet, Vicente, Martínez-Climent, Jose A., Mateos, Maria C., Cayuela, Maria L., Narla, Goutham, Odero, Maria D., and Vicente, Carmen

Published
2023
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11. On the early evolution of Local Group dwarf galaxy types: star formation and supernova feedback

Author

Bermejo-Climent, Jose R., Battaglia, Giuseppina, Gallart, Carme, Di Cintio, Arianna, Brook, Chris B., Cicuendez, Luis, Monelli, Matteo, Leaman, Ryan, Mayer, Lucio, Penarrubia, Jorge, and Read, Justin I.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

According to star formation histories (SFHs), Local Group dwarf galaxies can be broadly classified in two types: those forming most of their stars before $z=2$ (${\it fast}$) and those with more extended SFHs (${\it slow}$). The most precise SFHs are usually derived from deep but not very spatially extended photometric data; this might alter the ratio of old to young stars when age gradients are present. Here we correct for this effect and derive the mass formed in stars by $z=2$ for a sample of 16 Local Group dwarf galaxies. We explore early differences between ${\it fast}$ and ${\it slow}$ dwarfs, and evaluate the impact of internal feedback by supernovae (SN) on the baryonic and dark matter (DM) component of the dwarfs. ${\it Fast}$ dwarfs assembled more stellar mass at early times and have larger amounts of DM within the half-light radius than ${\it slow}$ dwarfs. By imposing that ${\it slow}$ dwarfs cannot have lost their gas by $z=2$, we constrain the maximum coupling efficiency of SN feedback to the gas and to the DM to be $\sim$10%. We find that internal feedback alone appears insufficient to quench the SFH of ${\it fast}$ dwarfs by gas deprivation, in particular for the fainter systems. Nonetheless, SN feedback can core the DM halo density profiles relatively easily, producing cores of the sizes of the half-light radius in ${\it fast}$ dwarfs by $z=2$ with very low efficiencies. Amongst the "classical" Milky Way satellites, we predict that the smallest cores should be found in Draco and Ursa Minor, while Sculptor and Fornax should host the largest ones., Comment: 15 pages, 3 figures, 2 tables. Accepted for publication in MNRAS

Published
2018
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12. Early Science with the Large Millimeter Telescope: Detection of dust emission in multiple images of a normal galaxy at $z>4$ lensed by a Frontier Fields cluster

Author

Pope, Alexandra, Montana, Alfredo, Battisti, Andrew, Limousin, Marceau, Marchesini, Danilo, Wilson, Grant W., Alberts, Stacey, Aretxaga, Itziar, Avila-Reese, Vladimir, Bermejo-Climent, Jose Ramon, Brammer, Gabriel, Bravo-Alfaro, Hector, Calzetti, Daniela, Chary, Ranga-Ram, Cybulski, Ryan, Giavalisco, Mauro, Hughes, David, Kado-Fong, Erin, Keller, Erica, Kirkpatrick, Allison, Labbe, Ivo, Lange-Vagle, Daniel, Lowenthal, James, Murphy, Eric, Oesch, Pascal, Gonzalez, Daniel Rosa, Sanchez-Arguelles, David, Shipley, Heath, Stefanon, Mauro, Vega, Olga, Whitaker, Katherine, Williams, Christina C., Yun, Min, Zavala, Jorge A., and Zeballos, Milagros

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We directly detect dust emission in an optically-detected, multiply-imaged galaxy lensed by the Frontier Fields cluster MACSJ0717.5+3745. We detect two images of the same galaxy at 1.1mm with the AzTEC camera on the Large Millimeter Telescope leaving no ambiguity in the counterpart identification. This galaxy, MACS071_Az9, is at z>4 and the strong lensing model (mu=7.5) allows us to calculate an intrinsic IR luminosity of 9.7e10 Lsun and an obscured star formation rate of 14.6 +/- 4.5 Msun/yr. The unobscured star formation rate from the UV is only 4.1 +/- 0.3 Msun/yr which means the total star formation rate (18.7 +/- 4.5 Msun/yr) is dominated (75-80%) by the obscured component. With an intrinsic stellar mass of only 6.9e9Msun, MACS0717_Az9 is one of only a handful of z>4 galaxies at these lower masses that is detected in dust emission. This galaxy lies close to the estimated star formation sequence at this epoch. However, it does not lie on the dust obscuration relation (IRX-beta) for local starburst galaxies and is instead consistent with the Small Magellanic Cloud (SMC) attenuation law. This remarkable lower mass galaxy showing signs of both low metallicity and high dust content may challenge our picture of dust production in the early Universe., Comment: 12 pages, 6 figures, accepted for publication in ApJ

Published
2017
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13. Conservation and Breeding of Mediterranean Pines

Author

Climent, José, Alizoti, Paraskevi, Rodriguez-Quilón, Isabel, Kurt, Yusuf, Ducci, Fulvio, Fady, Bruno, Alía, Ricardo, Tomé, Margarida, Series Editor, Seifert, Thomas, Series Editor, Kurttila, Mikko, Series Editor, Ne'eman, Gidi, editor, and Osem, Yagil, editor

Published
2021
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14. The alternative RelB NF-κB subunit is a novel critical player in diffuse large B-cell lymphoma

Author

Eluard, Baptiste, Nuan-Aliman, Stéphanie, Faumont, Nathalie, Collares, Davi, Bordereaux, Didier, Montagne, Aurélie, Martins, Isabelle, Cagnard, Nicolas, Caly, Martial, Taoui, Oussama, Lordello, Leonardo, Lehmann-Che, Jacqueline, Tesson, Bruno, Martinez-Climent, Jose-Angel, Copie-Bergman, Christiane, Haioun, Corinne, Tilly, Hervé, Bonsang, Benjamin, Vincent-Salomon, Anne, Jais, Jean-Philippe, Jardin, Fabrice, Leroy, Karen, Maiuri, Maria Chiara, Kroemer, Guido, Molina, Thierry Jo, Feuillard, Jean, and Baud, Véronique

Published
2022
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17. Deep MRD profiling defines outcome and unveils different modes of treatment resistance in standard- and high-risk myeloma

Author

Goicoechea, Ibai, Puig, Noemi, Cedena, Maria-Teresa, Burgos, Leire, Cordón, Lourdes, Vidriales, María-Belén, Flores-Montero, Juan, Gutierrez, Norma C., Calasanz, Maria-Jose, Ramos, Maria-Luisa Martin, Lara-Astiaso, David, Vilas-Zornoza, Amaia, Alignani, Diego, Rodriguez, Idoia, Sarvide, Sarai, Alameda, Daniel, Garcés, Juan José, Rodriguez, Sara, Fresquet, Vicente, Celay, Jon, Garcia-Sanz, Ramón, Martinez-Lopez, Joaquin, Oriol, Albert, Rios, Rafael, Martin-Sanchez, Jesus, Martinez-Martinez, Rafael, Sarra, Josep, Hernandez, Miguel-Teodoro, de la Rubia, Javier, Krsnik, Isabel, Moraleda, Jose-Maria, Palomera, Luis, Bargay, Joan, Martinez-Climent, Jose-Angel, Orfao, Alberto, Rosiñol, Laura, Mateos, Maria-Victoria, Lahuerta, Juan-José, Blade, Joan, San Miguel, Jesús, and Paiva, Bruno

Published
2021
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21. PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomas

Author

Pascual, Marién, Mena-Varas, María, Robles, Eloy Francisco, Garcia-Barchino, Maria-Jose, Panizo, Carlos, Hervas-Stubbs, Sandra, Alignani, Diego, Sagardoy, Ainara, Martinez-Ferrandis, Jose Ignacio, Bunting, Karen L., Meier, Stephen, Sagaert, Xavier, Bagnara, Davide, Guruceaga, Elizabeth, Blanco, Oscar, Celay, Jon, Martínez-Baztan, Alvaro, Casares, Noelia, Lasarte, Juan José, MacCarthy, Thomas, Melnick, Ari, Martinez-Climent, Jose Angel, and Roa, Sergio

Published
2019
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22. Chloroplast microsatellites reveal colonization and metapopulation dynamics in the Canary Island pine

Author

Navascués, Miguel, Vaxevanidou, Zafeiro, González-Martínez, Santiago C, Climent, José, Gil, Luis, and Emerson, Brent C

Subjects
Quantitative Biology - Populations and Evolution
Abstract

Chloroplast microsatellites are becoming increasingly popular markers for population genetic studies in plants, but there has been little focus on their potential for demographic inference. In this work the utility of chloroplast microsatellites for the study of population expansions was explored. First, we investigated the power of mismatch distribution analysis and the F(S) test with coalescent simulations of different demographic scenarios. We then applied these methods to empirical data obtained for the Canary Island pine (Pinus canariensis). The results of the simulations showed that chloroplast microsatellites are sensitive to sudden population growth. The power of the F(S) test and accuracy of demographic parameter estimates, such as the time of expansion, were reduced proportionally to the level of homoplasy within the data. The analysis of Canary Island pine chloroplast microsatellite data indicated population expansions for almost all sample localities. Demographic expansions at the island level can be explained by the colonization of the archipelago by the pine, while population expansions of different ages in different localities within an island could be the result of local extinctions and recolonization dynamics. Comparable mitochondrial DNA sequence data from a parasite of P. canariensis, the weevil Brachyderes rugatus, supports this scenario, suggesting a key role for volcanism in the evolution of pine forest communities in the Canary Islands.

Published
2008
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24. P1225: CYLD, A NOVEL REGULATOR OF SPLENIC MARGINAL ZONE LYMPHOMA PATHOGENESIS

Author

Pseftogkas, Athanasios, primary, Bordini, Jessica, additional, Frenquelli, Michela, additional, Bonfiglio, Ferdinando, additional, Daibata, Masanori, additional, Ángel Martínez-Climent, José, additional, Mosialos, George, additional, Rossi, Davide, additional, Campanella, Alessandro, additional, Xanthopoulos, Konstantinos, additional, and Ghia, Paolo, additional

Published
2023
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25. The GenTree Dendroecological Collection, tree-ring and wood density data from seven tree species across Europe

Author

Martínez-Sancho, Elisabet, Slámová, Lenka, Morganti, Sandro, Grefen, Claudio, Carvalho, Barbara, Dauphin, Benjamin, Rellstab, Christian, Gugerli, Felix, Opgenoorth, Lars, Heer, Katrin, Knutzen, Florian, von Arx, Georg, Valladares, Fernando, Cavers, Stephen, Fady, Bruno, Alía, Ricardo, Aravanopoulos, Filippos, Avanzi, Camilla, Bagnoli, Francesca, Barbas, Evangelos, Bastien, Catherine, Benavides, Raquel, Bernier, Frédéric, Bodineau, Guillaume, Bastias, Cristina C., Charpentier, Jean-Paul, Climent, José M., Corréard, Marianne, Courdier, Florence, Danusevicius, Darius, Farsakoglou, Anna-Maria, del Barrio, José M. García, Gilg, Olivier, González-Martínez, Santiago C., Gray, Alan, Hartleitner, Christoph, Hurel, Agathe, Jouineau, Arnaud, Kärkkäinen, Katri, Kujala, Sonja T., Labriola, Mariaceleste, Lascoux, Martin, Lefebvre, Marlène, Lejeune, Vincent, Le-Provost, Grégoire, Liesebach, Mirko, Malliarou, Ermioni, Mariotte, Nicolas, Matesanz, Silvia, Michotey, Célia, Milesi, Pascal, Myking, Tor, Notivol, Eduardo, Pakull, Birte, Piotti, Andrea, Plomion, Christophe, Pringarbe, Mehdi, Pyhäjärvi, Tanja, Raffin, Annie, Ramírez-Valiente, José A., Ramskogler, Kurt, Robledo-Arnuncio, Juan J., Savolainen, Outi, Schueler, Silvio, Semerikov, Vladimir, Spanu, Ilaria, Thévenet, Jean, Mette Tollefsrud, Mari, Turion, Norbert, Veisse, Dominique, Vendramin, Giovanni Giuseppe, Villar, Marc, Westin, Johan, and Fonti, Patrick

Published
2020
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26. Author Correction: The GenTree Dendroecological Collection, tree-ring and wood density data from seven tree species across Europe

Author

Martínez-Sancho, Elisabet, Slámová, Lenka, Morganti, Sandro, Grefen, Claudio, Carvalho, Barbara, Dauphin, Benjamin, Rellstab, Christian, Gugerli, Felix, Opgenoorth, Lars, Heer, Katrin, Knutzen, Florian, von Arx, Georg, Valladares, Fernando, Cavers, Stephen, Fady, Bruno, Alía, Ricardo, Aravanopoulos, Filippos, Avanzi, Camilla, Bagnoli, Francesca, Barbas, Evangelos, Bastien, Catherine, Benavides, Raquel, Bernier, Frédéric, Bodineau, Guillaume, Bastias, Cristina C., Charpentier, Jean-Paul, Climent, José M., Corréard, Marianne, Courdier, Florence, Danusevicius, Darius, Farsakoglou, Anna-Maria, García del Barrio, José M., Gilg, Olivier, González-Martínez, Santiago C., Gray, Alan, Hartleitner, Christoph, Hurel, Agathe, Jouineau, Arnaud, Kärkkäinen, Katri, Kujala, Sonja T., Labriola, Mariaceleste, Lascoux, Martin, Lefebvre, Marlène, Lejeune, Vincent, Le-Provost, Grégoire, Liesebach, Mirko, Malliarou, Ermioni, Mariotte, Nicolas, Matesanz, Silvia, Michotey, Célia, Milesi, Pascal, Myking, Tor, Notivol, Eduardo, Pakull, Birte, Piotti, Andrea, Plomion, Christophe, Pringarbe, Mehdi, Pyhäjärvi, Tanja, Raffin, Annie, Ramírez-Valiente, José A., Ramskogler, Kurt, Robledo-Arnuncio, Juan J., Savolainen, Outi, Schueler, Silvio, Semerikov, Vladimir, Spanu, Ilaria, Thévenet, Jean, Tollefsrud, Mari Mette, Turion, Norbert, Veisse, Dominique, Vendramin, Giovanni Giuseppe, Villar, Marc, Westin, Johan, and Fonti, Patrick

Published
2020
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28. Between but not within species variation in the distribution of fitness effects

Author

James, Jennifer, Kastally, Chedly, Budde, Katharina B., González-Martínez, Santiago C., Milesi, Pascal, Pyhäjärvi, Tanja, Alizoti, Paraskevi, Alía, Ricardo, Ambrosio, Olivier, Aravanopoulos, Filippos A., von Arx, Georg, Audrey, Albet, Auñón, Francisco, Avanzi, Camilla, Avramidou, Evangelia, Bagnoli, Francesca, Bajc, Marko, Ballesteros, Eduardo, Barbas, Evangelos, del Barrio, José M. García, Bastias, Cristina C., Bastien, Catherine, Beffa, Giorgia, Benavides, Raquel, Benoit, Vanina, Bernier, Frédéric, Bignalet, Henri, Bodineau, Guillaume, Bouic, Damien, Brodbeck, Sabine, Brunetto, William, Buchovska, Jurata, Buret, Corinne, Buy, Melanie, Cabanillas-Saldaña, Ana M., Carvalho, Bárbara, Cavers, Stephen, Del Caño, Fernando, Cervantes, Sandra, Cheval, Nicolas, Climent, José M., Correard, Marianne, Cremer, Eva, Danusevičius, Darius, Dauphin, Benjamin, Denou, Jean-Luc, Dokhelar, Bernard, Ducousso, Alexis, Fady, Bruno, Faivre-Rampant, Patricia, Farsakoglou, Anna-Maria, Fonti, Patrick, Ganopoulos, Ioannis, Gilg, Olivier, De Girardi, Nicolas, Graf, René, Gray, Alan, Grivet, Delphine, Gugerli, Felix, Hartleitner, Christoph, Heer, Katrin, Hollenbach, Enja, Hurel, Agathe, Issenhuth, Bernard, Jean, Florence, Jorge, Véronique, Jouineau, Arnaud, Kappner, Jan-Philipp, Kesälahti, Robert, Knutzen, Florian, Kujala, Sonja T., Kumpula, Timo A., Kärkkäinen, Katri, Labriola, Mariaceleste, Lalanne, Celine, Lambertz, Johannes, Le-Provost, Gregoire, Lejeune, Vincent, Lesur-Kupin, Isabelle, Levillain, Joseph, Liesebach, Mirko, López-Quiroga, David, Malliarou, Ermioni, Marchon, Jérémy, Mariotte, Nicolas, Mas, Antonio, Matesanz, Silvia, Meier, Benjamin, Meischner, Helge, Michotey, Célia, Morganti, Sandro, Myking, Tor, Nievergelt, Daniel, Eskild Nilsen, Anne, Notivol, Eduardo, Ojeda, Dario I., Olsson, Sanna, Opgenoorth, Lars, Ostreng, Geir, Pakull, Birte, Perry, Annika, Pinosio, Sara, Piotti, Andrea, Plomion, Christophe, Poinot, Nicolas, Pringarbe, Mehdi, Puzos, Luc, Raffin, Annie, Ramírez-Valiente, José A., Rellstab, Christian, Remi, Dourthe, Reutimann, Oliver, Richter, Sebastian, Robledo-Arnuncio, Juan J., Rogier, Odile, Sancho, Elisabet Martínez, Savolainen, Outi, Scalabrin, Simone, Schneck, Volker, Schueler, Silvio, Scotti, Ivan, Segundo, Sergio San, Semerikov, Vladimir, Slámová, Lenka, Spanu, Ilaria, Sønstebø, Jørn Henrik, Thevenet, Jean, Tollefsrud, Mari Mette, Turion, Norbert, Valladares, Fernando, Vendramin, Giovanni G., Villar, Marc, Westergren, Marjana, Westin, Johan, Lascoux, Martin, James, Jennifer, Kastally, Chedly, Budde, Katharina B., González-Martínez, Santiago C., Milesi, Pascal, Pyhäjärvi, Tanja, Alizoti, Paraskevi, Alía, Ricardo, Ambrosio, Olivier, Aravanopoulos, Filippos A., von Arx, Georg, Audrey, Albet, Auñón, Francisco, Avanzi, Camilla, Avramidou, Evangelia, Bagnoli, Francesca, Bajc, Marko, Ballesteros, Eduardo, Barbas, Evangelos, del Barrio, José M. García, Bastias, Cristina C., Bastien, Catherine, Beffa, Giorgia, Benavides, Raquel, Benoit, Vanina, Bernier, Frédéric, Bignalet, Henri, Bodineau, Guillaume, Bouic, Damien, Brodbeck, Sabine, Brunetto, William, Buchovska, Jurata, Buret, Corinne, Buy, Melanie, Cabanillas-Saldaña, Ana M., Carvalho, Bárbara, Cavers, Stephen, Del Caño, Fernando, Cervantes, Sandra, Cheval, Nicolas, Climent, José M., Correard, Marianne, Cremer, Eva, Danusevičius, Darius, Dauphin, Benjamin, Denou, Jean-Luc, Dokhelar, Bernard, Ducousso, Alexis, Fady, Bruno, Faivre-Rampant, Patricia, Farsakoglou, Anna-Maria, Fonti, Patrick, Ganopoulos, Ioannis, Gilg, Olivier, De Girardi, Nicolas, Graf, René, Gray, Alan, Grivet, Delphine, Gugerli, Felix, Hartleitner, Christoph, Heer, Katrin, Hollenbach, Enja, Hurel, Agathe, Issenhuth, Bernard, Jean, Florence, Jorge, Véronique, Jouineau, Arnaud, Kappner, Jan-Philipp, Kesälahti, Robert, Knutzen, Florian, Kujala, Sonja T., Kumpula, Timo A., Kärkkäinen, Katri, Labriola, Mariaceleste, Lalanne, Celine, Lambertz, Johannes, Le-Provost, Gregoire, Lejeune, Vincent, Lesur-Kupin, Isabelle, Levillain, Joseph, Liesebach, Mirko, López-Quiroga, David, Malliarou, Ermioni, Marchon, Jérémy, Mariotte, Nicolas, Mas, Antonio, Matesanz, Silvia, Meier, Benjamin, Meischner, Helge, Michotey, Célia, Morganti, Sandro, Myking, Tor, Nievergelt, Daniel, Eskild Nilsen, Anne, Notivol, Eduardo, Ojeda, Dario I., Olsson, Sanna, Opgenoorth, Lars, Ostreng, Geir, Pakull, Birte, Perry, Annika, Pinosio, Sara, Piotti, Andrea, Plomion, Christophe, Poinot, Nicolas, Pringarbe, Mehdi, Puzos, Luc, Raffin, Annie, Ramírez-Valiente, José A., Rellstab, Christian, Remi, Dourthe, Reutimann, Oliver, Richter, Sebastian, Robledo-Arnuncio, Juan J., Rogier, Odile, Sancho, Elisabet Martínez, Savolainen, Outi, Scalabrin, Simone, Schneck, Volker, Schueler, Silvio, Scotti, Ivan, Segundo, Sergio San, Semerikov, Vladimir, Slámová, Lenka, Spanu, Ilaria, Sønstebø, Jørn Henrik, Thevenet, Jean, Tollefsrud, Mari Mette, Turion, Norbert, Valladares, Fernando, Vendramin, Giovanni G., Villar, Marc, Westergren, Marjana, Westin, Johan, and Lascoux, Martin

Abstract

New mutations provide the raw material for evolution and adaptation. The distribution of fitness effects (DFE) describes the spectrum of effects of new mutations that can occur along a genome, and is therefore of vital interest in evolutionary biology. Recent work has uncovered striking similarities in the DFE between closely related species, prompting us to ask whether there is variation in the DFE among populations of the same species, or among species with different degrees of divergence, i.e., whether there is variation in the DFE at different levels of evolution. Using exome capture data from six tree species sampled across Europe we characterised the DFE for multiple species, and for each species, multiple populations, and investigated the factors potentially influencing the DFE, such as demography, population divergence and genetic background. We find statistical support for there being variation in the DFE at the species level, even among relatively closely related species. However, we find very little difference at the population level, suggesting that differences in the DFE are primarily driven by deep features of species biology, and that evolutionarily recent events, such as demographic changes and local adaptation, have little impact.

Published
2023

29. Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance

Author

Instituto de Salud Carlos III, European Commission, Fundación Científica Asociación Española Contra el Cáncer, Cancer Research UK, Fondazione Italiana per la Ricerca sul Cancro, Multiple Myeloma Research Foundation, European Hematology Association, European Research Council, Leukemia & Lymphoma Society (US), Bristol-Myers Squibb, Fondazione Regionale per la Ricerca Biomedica, Botta, Cirino, Pérez, Cristina, Larrayoz, Marta, Puig, Noemi, Cedena, Maria-Teresa, Termini, Rosalinda, Goicoechea, Ibai, Rodriguez, Sara, Zabaleta, Aintzane, López, Aitziber, Sarvide, Sarai, Blanco, Laura, Papetti, Daniele M., Nobile, Marco S., Besozzi, Daniela, Gentile, Massimo, Correale, Pierpaolo, Siragusa, Sergio, Oriol, Albert, González García, María-Esther, Sureda, Anna, Arriba, Felipe de, Ríos Tamayo, Rafael, Moraleda, José María, Gironella, Mercedes, Hernández, Miguel T., Bargay, Joan, Palomera, Luis, Pérez-Montaña, Albert, Goldschmidt, Hartmut, Avet-Loiseau, Hervé, Roccaro, Aldo, Orfao, Alberto, Martínez-López, Joaquín, Rosiñol, Laura, Lahuerta, Juan José, Bladé, Joan, Mateos, Maria Victoria, San-Miguel, Jesús, Martínez-Climent, José Ángel, Paiva, Bruno, Instituto de Salud Carlos III, European Commission, Fundación Científica Asociación Española Contra el Cáncer, Cancer Research UK, Fondazione Italiana per la Ricerca sul Cancro, Multiple Myeloma Research Foundation, European Hematology Association, European Research Council, Leukemia & Lymphoma Society (US), Bristol-Myers Squibb, Fondazione Regionale per la Ricerca Biomedica, Botta, Cirino, Pérez, Cristina, Larrayoz, Marta, Puig, Noemi, Cedena, Maria-Teresa, Termini, Rosalinda, Goicoechea, Ibai, Rodriguez, Sara, Zabaleta, Aintzane, López, Aitziber, Sarvide, Sarai, Blanco, Laura, Papetti, Daniele M., Nobile, Marco S., Besozzi, Daniela, Gentile, Massimo, Correale, Pierpaolo, Siragusa, Sergio, Oriol, Albert, González García, María-Esther, Sureda, Anna, Arriba, Felipe de, Ríos Tamayo, Rafael, Moraleda, José María, Gironella, Mercedes, Hernández, Miguel T., Bargay, Joan, Palomera, Luis, Pérez-Montaña, Albert, Goldschmidt, Hartmut, Avet-Loiseau, Hervé, Roccaro, Aldo, Orfao, Alberto, Martínez-López, Joaquín, Rosiñol, Laura, Lahuerta, Juan José, Bladé, Joan, Mateos, Maria Victoria, San-Miguel, Jesús, Martínez-Climent, José Ángel, and Paiva, Bruno

Abstract

Tumor recognition by T cells is essential for antitumor immunity. A comprehensive characterization of T cell diversity may be key to understanding the success of immunomodulatory drugs and failure of PD-1 blockade in tumors such as multiple myeloma (MM). Here, we use single-cell RNA and T cell receptor sequencing to characterize bone marrow T cells from healthy adults (n = 4) and patients with precursor (n = 8) and full-blown MM (n = 10). Large T cell clones from patients with MM expressed multiple immune checkpoints, suggesting a potentially dysfunctional phenotype. Dual targeting of PD-1 + LAG3 or PD-1 + TIGIT partially restored their function in mice with MM. We identify phenotypic hallmarks of large intratumoral T cell clones, and demonstrate that the CD27− and CD27+ T cell ratio, measured by flow cytometry, may serve as a surrogate of clonal T cell expansions and an independent prognostic factor in 543 patients with MM treated with lenalidomide-based treatment combinations.

Published
2023

32. DNA methylation profiling identifies two splenic marginal zone lymphoma subgroups with different clinical and genetic features

Author

Arribas, Alberto J., Rinaldi, Andrea, Mensah, Afua A., Kwee, Ivo, Cascione, Luciano, Robles, Eloy F., Martinez-Climent, Jose A., Oscier, David, Arcaini, Luca, Baldini, Luca, Marasca, Roberto, Thieblemont, Catherine, Briere, Josette, Forconi, Francesco, Zamò, Alberto, Bonifacio, Massimiliano, Mollejo, Manuela, Facchetti, Fabio, Dirnhofer, Stephan, Ponzoni, Maurilio, Bhagat, Govind, Piris, Miguel A., Gaidano, Gianluca, Zucca, Emanuele, Rossi, Davide, and Bertoni, Francesco

Published
2015
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35. Local seed sourcing for sustainable forestry

Author

Alía, Ricardo, primary, Notivol, Eduardo, additional, Climent, José, additional, Pérez, Felipe, additional, Barba, Diana, additional, Majada, Juan, additional, and García del Barrio, José Manuel, additional

Published
2022
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41. Immune Biomarkers of Survival and Severe Infection in Newly Diagnosed Multiple Myeloma (NDMM) Patients (pts) Treated with the Backbone Regimen Lenalidomide and Dexamethasone (Rd)

Author

Maia, Catarina, Puig, Noemi, Pérez Ruiz, Cristina, Cedena Romero, Maria Teresa, Guerrero, Camila, Larrayoz, Marta, Botta, Cirino, Gutierrez, Norma C., Calasanz, María José, Martin-Ramos, Maria Luisa, Hernández, Miguel, Rosinol Dachs, Laura, Garcia, Esther González, De Arriba, Felipe, Oriol, Albert, Gonzalez-Calle, Veronica, Escalante, Fernando, de la Rubia, Javier, Gironella Mesa, Mercedes, Rios, Rafael, Garcia Sanchez, Ricarda Belen, Arguiñano PEREZ, Jose Maria, Alegre, Adrian, Martin, Jesus, Couto Caro, María del Carmen, Casanova, Maria, Herraiz, Mario Arnao, Pérez, Ernesto, Garzón López, Sebastián, Gonzalez Perez, Marta Sonia, Martín-Nuñez, Guillermo, Rossi, Adriana, Coleman, Morton, Encinas, Cristina, Vale, Ana M., Teruel, Ana Isabel, Cortés Rodríguez, María, Martinez-Climent, Jose A., Lahuerta, Juan-José, Bladé Creixenti, Joan, Niesvizky, Ruben, San-Miguel, Jesús, Mateos, Maria-Victoria, and Paiva, Bruno

Published
2022
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46. Straightening the crooked: Intraspecific divergence of stem posture control and associated trade-offs in a model conifer

Author

Ministerio de Economía, Industria y Competitividad (España), European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia e Innovación (España), Sierra-De-Grado, Rosario, Pando, Valentín, Voltas, Jordi, Zas Arregui, Rafael, Majada, Juan, Climent, José, Ministerio de Economía, Industria y Competitividad (España), European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia e Innovación (España), Sierra-De-Grado, Rosario, Pando, Valentín, Voltas, Jordi, Zas Arregui, Rafael, Majada, Juan, and Climent, José

Abstract

Although the straightening capacity of the stem is key for light capture and mechanical stability in forest trees, little is known about its adaptive implications. Assuming that stem straightening is costly, trade-offs are expected with competing processes such as growth, maintenance, and defence. We established a manipulative experiment in a common garden of Pinus pinaster including provenances typically showing either straight-stemmed or crooked-stemmed phenotypes. We imposed a bending up to 35º on plants aged 9 years of both provenance groups and followed the straightening kinetics and shoot elongation after releasing. Eight months later, we destructively assessed biomass partitioning, reaction wood, wood microdensity, xylem reserve carbohydrates, and phloem secondary metabolites. The experimental bending and release caused significant, complex changes with a marked difference between straight- and crooked-type plants. The straight-type recovered verticality faster and to a higher degree and developed more compression wood, while displaying a transitory delay in shoot elongation, reducing resource allocation to defence and maintaining the levels of non-structural carbohydrates compared with the crooked type. This combination of responses indicates the existence of intraspecific divergence in the reaction to mechanical stresses that may be related to different adaptive phenotypic plasticity.

Published
2022

48. Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice

Author

Vicente-Dueñas, Carolina, Fontán, Lorena, Gonzalez-Herrero, Ines, Romero-Camarero, Isabel, Segura, Victor, Aznar, M. Angela, Alonso-Escudero, Esther, Campos-Sanchez, Elena, Ruiz-Roca, Lucía, Barajas-Diego, Marcos, Sagardoy, Ainara, Martinez-Ferrandis, Jose I., Abollo-Jimenez, Fernando, Bertolo, Cristina, Peñuelas, Ivan, Garcia-Criado, Francisco J., García-Cenador, María B., Tousseyn, Thomas, Agirre, Xabier, Prosper, Felipe, Garcia-Bragado, Federico, McPhail, Ellen D., Lossos, Izidore S., Du, Ming-Qing, Flores, Teresa, Hernandez-Rivas, Jesus M., Gonzalez, Marcos, Salar, Antonio, Bellosillo, Beatriz, Conde, Eulogio, Siebert, Reiner, Sagaert, Xavier, Cobaleda, Cesar, Sanchez-Garcia, Isidro, and Martinez-Climent, Jose A.

Published
2012

50. A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma

Author

Beltran, Elena, Fresquet, Vicente, Martinez-Useros, Javier, Richter-Larrea, Jose A., Sagardoy, Ainara, Sesma, Izaskun, Almada, Luciana L., Montes-Moreno, Santiago, Siebert, Reiner, Gesk, Stefan, Calasanz, Maria J., Malumbres, Raquel, Rieger, Melissa, Prosper, Felipe, Lossos, Izidore S., Piris, Miguel Angel, Fernandez-Zapico, Martin E., and Martinez-Climent, Jose A.

Published
2011

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