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GO terms for interacting partners of neurexins. A) Biological processes. B) Cellular components. C) Molecular functions. All: total number of proteins analyzed. The number above each bar indicates the number of proteins assigned to that category. Figure generated by WebGestalt (http://www.webgestalt.org) [18];GeneMANIA Report;Physiological and pathway data for interacting partners of neurexins

Africa is not unique in its need for basic bioinformatics training for individuals from a diverse range of academic backgrounds. However, particular logistical challenges in Africa, most notably access to bioinformatics expertise and internet stability, must be addressed in order to meet this need on the continent. H3ABioNet (www.h3abionet.org), the Pan African Bioinformatics Network for H3Africa, has therefore developed an innovative, free-of-charge “Introduction to Bioinformatics” course, taking these challenges into account as part of its educational efforts to provide on-site training and develop local expertise inside its network. A multiple-delivery–mode learning model was selected for this 3-month course in order to increase access to (mostly) African, expert bioinformatics trainers. The content of the course was developed to include a range of fundamental bioinformatics topics at the introductory level. For the first iteration of the course (2016), classrooms with a total of 364 enrolled participants were hosted at 20 institutions across 10 African countries. To ensure that classroom success did not depend on stable internet, trainers pre-recorded their lectures, and classrooms downloaded and watched these locally during biweekly contact sessions. The trainers were available via video conferencing to take questions during contact sessions, as well as via online “question and discussion” forums outside of contact session time. This learning model, developed for a resource-limited setting, could easily be adapted to other settings.

RMSD of the backbone atoms of model Rv1712 (green) and substrate C5P (red) during the 30000Â ps simulation. Generated using Gnuplotv4.2 [41]. (PDF 198 kb)

KEGG pathways for genes known to be associated with 1st and 2nd line drug resistance. The 10 mutations (eight genes) indicated in bold were verified by the BROAD institute, while the remainder were identified from literature. Abbreviations used: A-Adenine, Ala-Alanine, Arg-Arginine, Asn-Glutamine, Asp-Aspartate, Gly-Glycine, His-Histidine, indel-insertion deletion, Ileu-Isoleucine, Leu-Leucine, Met-Methionine, N.A-Not available, Pro-Proline, Ser-Serine, T-Thymidine, Thr-Threonine, Tyr-Tyrosine, Val-Valine. (PDF 143 kb)

KEGG metabolic pathway map for Nucleotide metabolism (pyrimidine metabolism) in M. tuberculosis H37rV strain. Rv1712 or cmk selected for investigation is shown in red highlighted boxes and involved in step 2.7.4.14 of this specific pathway. Known drug resistance gene Rv0667 or rpoB is shown in blue highlighted box and involved in step 2.7.7.6 of this pathway. M. tuberculosis specific genes are coloured in green. (PDF 111 kb)

KEGG metabolic pathway map for Oxidative phosphorylation in M. tuberculosis H37rV strain. Rv2984 or ppk selected for investigation is shown in blue highlighted box and involved in step 2.7.4.1 of this specific pathway. Rv2194 or qcrC selected for investigation is shown in the red highlighted box. Both Rv1305 (atpE) and Rv1311 (atpC) selected for investigation are shown in brown highlighted box and involved in step 3.6.3.14 of this specific pathway. Rv2195 or qcrA selected for investigation is shown in the yellow highlighted box involved in cytochrome C reductase. Rv1456c or COX15 selected for investigation is shown in the magenta highlighted box involved in cytochrome C oxidase. Rv1622c or CydB selected for investigation is shown in the light blue highlighted box involved in cytochrome C oxidase. Known drug resistance gene Rv1854c or ndh is shown in orange highlighted box and involved in step 1.6.99.3 of this pathway. M. tuberculosis specific genes are coloured in green. (PDF 157 kb)

KEGG metabolic pathway map for Nicotinate and Nicotinamide metabolism in M. tuberculosis H37rV strain. Rv2421c or nadD selected for investigation is shown in red highlighted box and involved in step 2.7.7.18 of this specific pathway. Known drug resistance gene Rv2043c or pncA is shown in blue highlighted box and involved in step 3.5.1.19 of this pathway. M. tuberculosis specific genes are coloured in green. (PDF 106 kb)

DOPE score energy profiles graph of the structural model for Rv1712 (red) and templates 1Q3T (green), 1CKE (dark blue), 1KDO (light blue) and 2H92 (purple). Generated using Gnuplotv4.2 [41]. (PDF 68 kb)