INTRODUCTION: The immune response combines a series of signals and complex mechanisms to occur, which can be modulated and enhanced. This one according the popular knowledge is possible using plant extracts, being one of them the plant extract JV-001. This showed, in previous studies, the ability to activate and enhance the cellular immune response of murine origin, but its effect on human leukocyte level is unknown, so the objective of this work was to study the effect of JV-001 in human leukocytes. MATERIAL AND METHOD: In this paper was used heparinized blood of healthy males, at first instance, this was treated with NH4Cl 64% to obtain total leukocytes, and in another, separate the mononuclear fraction by Histopaque® gradient. The cells obtained were adjusted to 8x106; aliquots of 100 µL of JV-001 or PBS. The plate was incubated at 37°C for 30 minutes and then washed, the peroxidase remaining in each recipient was revealed and determined with Orthophenylenediamine and H2O2, expressing the proceeds as absorbance read at 450 nm. RESULTS: The results showed an increase in total leukocyte adhesion between 44.35% and 63.3%, expressed by obtaining a positive delta absorbance with respect to controls. DISCUSSION: The mechanism that increases the adhesion is unknown, but probably due to increased expression of integrins. It is important to note that this increase does not occur upon incubation of mononuclear or polymorphonuclear cells separately, suggesting that the active principle of JV-001 not only does not act directly on adherent cells. [ABSTRACT FROM AUTHOR]