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Manuel Cobo,1 Vanesa Gutiérrez,1 Rosa Villatoro,2 Jose Manuel Trigo,1 Inmaculada Ramos,1 Omar López,1 María Ruiz,1 Ana Godoy,1 Irene López,1 Macarena Arroyo3 1Medical Oncology Department, Hospital Universitario Málaga Regional y Virgen de la Victoria, IBIMA, 2Medical Oncology Department, Hospital Costa del Sol, Marbella, IBIMA, 3Pneumology Department, Hospital Universitario Málaga Regional, IBIMA, Málaga, Spain Abstract: The vascular endothelial growth factor (VEGF) and receptor is a therapeutic target because of the importance of this pathway in carcinogenesis. This pathway regulates and promotes angiogenesis as well as increases endothelial cell proliferation, permeability, and cancer survival. Ramucirumab is a new fully human monoclonal antibody that targets the VEGF receptor-2, an important key receptor implicated in angiogenesis. Ramucirumab has been approved for the treatment of second-line advanced or metastatic non-small cell lung cancer (NSCLC) in combination with the chemotherapy agent docetaxel. This was based on the result of the randomized trial REVEL of 1,253 patients with metastatic NSCLC previously treated with a platinum-based combination therapy. The authors observed a significant improvement in overall survival (OS) with an acceptable toxicities profile. In this study, patients were randomized to receive ramucirumab plus docetaxel or placebo with docetaxel. The combination of docetaxel and ramucirumab showed an improved OS (hazard ratio [HR]: 0.86; 95% CI: 0.75, 0.98). Median OS was 10.5 months in the ramucirumab arm versus 9.1 months in the placebo arm. Regarding side effects, the toxicity described on the ramucirumab arm were principally diarrhea, fatigue, and neutropenia. The most common (5%) adverse reactions of grade 3 and 4 in the ramucirumab arm were fatigue, neutropenia, febrile neutropenia, leukopenia, and hypertension. Adding ramucirumab to docetaxel improves QoL of patients, and does not impair symptoms or functioning. There are currently several trials in progress evaluating the effects of ramucirumab in combination with other drugs in patients with advanced NSCLC. Keywords: ramucirumab, NSCLC, antiangiogenesis, VEGF-targeted therapy, pretreated

Introduction: Presents the first bibliometric study on the evolution of the fuzzy sets theory field. It is specially focused on the research carried out by the Spanish community. Method. The CoPalRed software, for network analysis, and the co-word analysis technique are used. Analysis: Bibliometric maps showing the main associations among the main concepts in the field are provided for the periods 1965-1993, 1994-1998, 1999-2003 and 2004-2008. Results: The bibliometric maps obtained provide insight into the structure of the fuzzy sets theory research in the Spanish community, visualize the research subfields, and show the existing relationships between those subfields. Furthermore, we compare the Spanish community with other countries (the USA and Canada; the UK and Germany; and Japan and Peoples Republic of China). Conclusions: As a result of the analysis, a complete study of the evolution of the Spanish fuzzy sets community and an analysis of its international importance are presented. (Contains 12 tables and 21 figures.)

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Resumen: Objetivo: Determinar los factores asociados al ataque cerebrovascular isquémico en el servicio de urgencias de la Clínica Especializada Los Andes, de la ciudad de Tunja, entre los años 2013 a 2016. Pacientes y métodos: Estudio de casos y controles; los casos correspondieron a 97 pacientes con ataque cerebrovascular isquémico (infarto cerebral isquémico y accidente isquémico transitorio) y los controles a 291 pacientes sin ataque cerebrovascular isquémico que ingresaron a urgencias entre los años 2013 a 2016. Resultados: El sexo femenino correspondió al 56,7% (55) de los casos y al 54,6% de los controles (154) (p = 0,069). La media de edad en el grupo caso fue de 73,7 años [DE: 10,5 años] y en los controles de 64,5 años [DE: 11,3 años]. Los factores asociados al ataque cerebrovascular isquémico fueron: antecedente de ataque cerebrovascular isquémico [OR 7,7 IC 95% 3,2; 18 p= 0,000], tabaquismo [OR 4,4 IC 95% 1,1; 18 p= 0,022], dislipidemia [OR 3 IC 95% 1,2; 7,5 p= 0,017], edad igual o mayor a 70 años [OR 2,3 IC 95% 1,3; 4,1 p= 0,002] e hipertensión arterial [OR 1,8 IC 95% 1,06; 3,3 p= 0,029]. Conclusiones: Los factores asociados al ataque cerebrovascular isquémico fueron, en orden de importancia, antecedente de ataque cerebrovascular isquémico, tabaquismo, dislipidemia, edad igual o mayor a 70 años e hipertensión arterial. Abstract: Objective: To determine the factors associated with ischaemic cerebrovascular accidents (ICVA) in the Emergency Department of the Andes Specialist Clinic of the city of Tunja, between the years 2013 and 2016. Patients and methods: A case-control study was conducted in which the cases consisted of 97 patients with ICVA (ischaemic cerebral infarction and transient ischaemic accident), and the controls were 291 patients with no ICVA, who were admitted to the Emergency Department between the years 2013 and 2016. Results: There were 56.7% (55) females in the cases, and 54.6% (154) in the controls (P=.069). The mean age of the cases was 73.7 years [SD: 10.5 years], and 64.5 years [SD: 11.3 years] in the controls. The factors associated with ICVA were: a history of ICVA [OR; 7.7, 95% CI; 3.2â18, P=.000], smoking [OR; 4.4, 95% CI; 1.1â18, P=.022], dyslipidaemia [OR; 3, 95% CI; 1.2â7.5, P=.017], age equal to or greater than 70 years [OR; 2.3, 95% CI; 1.3â4.1, P=.002], and arterial hypertension [OR; 1.8, 95% CI; 1.06â3.3, P=.029]. Conclusions: The factors associated with ischaemic cerebrovascular accident were, in order of importance, a history of ischaemic cerebrovascular accident, smoking, dyslipidaemia, age equal to or greater than 70 years, and arterial hypertension. Palabras clave: Circulación cerebrovascular, Cerebro, Factores de riesgo, Keywords: Cerebrovascular circulation, Brain, Risk factors

The paradigm shift in media and social communications is forcing us to rethinking the role and responsibility of the user. Studies on consumer ethics are relatively recent and have shown little interest in the ethical decision-making processes of media users and consumers. In the side of media ethics, the attention paid to consumers and users of the media has also been scarce. The aim of this article is to identify principles and criteria that may serve as guidelines for a media users’ ethics adapted to the current times and technologies. The reflection starts with a review of the academic literature and the principles, values and norms that can be traced in the documents of the Catholic Social Teaching (CST) on media ethics.

This article examines how the research into Lean Supply Chain Management (LSCM) has evolved over the period 1996–2018 with the identification of the main issues explored and future trends. A performance bibliometric analysis has been conducted through a study of published documents, citations, journal impact factor, h-index, most cited papers and authors, and data on the geographic distribution of publications. More relevantly, a science mapping analysis has been performed with SciMAT bibliometric analysis software using co-word networks in a longitudinal overview. The large number of studies of LSCM published has enabled a conceptual evolution map to be constructed of the way that this research has developed. The results have enabled us to identify four thematic areas in the LSCM field: Methods, Key factors, Internal efficiency, and Performance. [ABSTRACT FROM AUTHOR]