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1. Cause-specific death in hospitalized individuals infected with SARS-CoV-2: more than just acute respiratory failure or thromboembolic events

Author

Cobos-Siles, Marta, Cubero-Morais, Pablo, Arroyo-Jiménez, Irene, Rey-Hernández, María, Hernández-Gómez, Laura, Vargas-Parra, Derly Judith, González-Fernández, María, Cazorla-González, Marina, Gabella-Martín, Miriam, Ruíz-Albi, Tomás, Berezo-García, José Angel, García-Cruces-Méndez, Jesús Fernando, Miramontes-González, José Pablo, and Corral-Gudino, Luis

Published
2020
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2. Cuidados en los últimos días de vida en los pacientes hospitalizados en medicina interna

Author

Díez-Manglano, Jesús, Isasi de Isasmendi Pérez, Soledad, Rubio Gómez, Marta, Martín Pérez, Magdalena, Díez García, Luis Felipe, Vallejo Maroto, Ignacio, Ocaña Losada, Cristina, Giner Escobar, Pilar, Díaz Pérez, Catalina, Caballero Granado, Javier, García Font, Resfa María, Jódar Lorente, Francisco J., Pérez Vázquez, Gloria, Ferro Expósito, Ana Belén, Amaya González, María Luisa, Gamboa Antiñolo, Fernando, González Molina, Álvaro, Gómez Hernández, Mercedes, Guzmán García, Marcos, Benítez León, Lola, Montero Rivas, Lorena, Ruiz Mariscal, María, Gómez Aguirre, Noelia, González García, María Pilar, Martín Algora, Isabel, Bueno Castel, María Carmen, Ruiz Laiglesia, Fernando, Bejarano Tello, Esperanza, Cabrerizo García, José Luis, Guiral Fernández, Nuria, Camera, Luis, Gauna, Carla, Abad Requejo, Pedro, Martínez Gutiérrez, Rocío, Fernández Regueiro, Rebeca, Sánchez Vidal, María Teresa, Alfonso Mejido, Joaquín, García Carús, Enrique, Calvo Rodríguez, Carmen Elena, Martínez García, Paula, Ruiz Olivares, Sixto, Fullana Barcelo, María Isabel, González Arencibia, Carmen, Ros Vilamajó, Rosa, Monedero Prieto, María José, González Becerra, Concepción, Pérez, Sofía, Martín Plata, Andrea, Portilla Chocarro, Raquel, Dueñas Gutiérrez, Carlos, Estrada Álvarez, Francisco, Peña Balbuena, Sonia, Rodríguez Galindo, Raúl, Cobos Siles, Marta María, Sánchez Muñoz, Luis Ángel, Castañón López, Ana, Sanz Lobo, Celia, Chimeno Viñas, María Montserrat, Contreras Uriel, María Ángeles, Gil Domínguez, Judit, Medrano González, Francisco, Machín Lázaro, José Manuel, Magallanes Gamboa, Jeffrey, Rodríguez Galdeano, Mónica, Castro Giménez, Joaquín, Barberá Farré, José Ramón, Núñez Aragón, Raquel, Masanés Torán, Ferrán, Barbé, José, Güell Farré, Elena, Torres Bonafonte, Olga, Lozano Miñana, Ana, Moras Sarabia, Desirée, Pérez, Rosa, Arnau i Fernández, Dolors, Formiga, Francesc, Fernández Fernández, Javier, Castro Salomó, Antoni, Qanneta, Rami, Pardo Ortega, María Victoria, Estrada Díaz, Cristina, Monterroso Pintado, Yasmina, García Cors, Montserrat, Almendros Rivas, María Cruz, Domingo Albin, Dolors, Roig Morera, Jaume, Galofré Álvaro, Nuria, Toro Parodi, Aythami, Loureiro Sánchez, Mario, de la Guerra Acebal, Carla, Zubizarreta García, Javier, Benavente Claveras, Iasone, Martí Cabanes, Juan, Sanz Lázaro, Ignacio, Barquero Romero, José, Nevado López-Alegría, Leticia, Arévalo Lorido, José Carlos, Casariego Vales, Emilio, Lorenzo Vizcaya, Ana María, Macía Rodríguez, Cristina, Pérez Fernández, Silvia, Sesma Sánchez, Pascual, Jiménez-Beatty, María Dolores, González Vázquez, Laura, Brea Hernando, Ángel, Castiella Herrero, Jesús, González Anglada, María Isabel, Gracia Lorenzo, Virginia M., Pérez Martín, Alejandro, García Melcón, Gerardo, Gómez Antúnez, María, Quesada Simón, María Angustias, Gil Gil, Fuensanta, Asenjo Martínez, María, Mancebo Aragoneses, Lourdes, Calderón Parra, Jorge, Romero Pérez, María del Carmen, Curbelo García, José, Laguna Cuesta, Fernando, Segovia Abad, María Eugenia, Fontecha Ortega, María, Lara Martínez, Guillermina, Pinos Blanco, Ana, Rodil Fraile, Raquel, Martínez Litago, Elisabel, Echeverría Echeverría, Aitziber, Priego Valladares, Manuel, Trescoli Serrano, Carlos, Vicente Mas, Josep, Torregrosa Suau, Óscar, Gil Tomás, Eva, Castillo Rubio, Rafael, Murcia Zaragoza, José Manuel, Román Sánchez, Pilar, García Herola, Ana, Tenllado Doblas, Pedro Pablo, Blázquez Encinar, Julio César, Castellano Vela, Enrique, Carrizo, Néstor, Giner Galvañ, Vicente, Roca Villanueva, Bernardino Manuel, Pasquau Liaño, Francisco, Pascual Izuel, José María, Díez-Manglano, J., Isasi de Isasmendi Pérez, S., Rubio Gómez, M., Formiga, F., Sánchez Muñoz, L.Á., Castiella Herrero, J., Casariego Vales, E., and Torres Bonafonte, O.H.

Published
2019
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3. Gender-Based Differences by Age Range in Patients Hospitalized with COVID-19: A Spanish Observational Cohort Study

Author

Josa Laorden, Claudia, Crestelo Vieitez, Anxela, García Andreu, María, Rubio-Rivas, Manuel, Sánchez, Marcos, Toledo Samaniego, Neera, Arnalich Fernández, Francisco, Iguaran Bermudez, Rosario, Fonseca Aizpuru, Eva, Vargas Núñez, Juan Antonio, Pesqueira Fontan, Paula Maria, Serrano Ballesteros, Jorge, Freire Castro, Santiago, Pestaña Fernández, Melani, Viana García, Alba, Nuñez Rodriguez, Victoria, Giner Galvañ, Vicente, Carrasco Sánchez, Francisco, Hernández Milián, Almudena, Cobos Siles, Marta, Napal Lecumberri, Jose, Herrero García, Virginia, Pascual Pérez, Maria, Millán Núñez-Cortés, Jesús, Casas Rojo, José, SEMI-COVID-19 Network, UAM. Departamento de Medicina, and Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)

Subjects
medicine.medical_specialty, Multivariate analysis, Medicina, medicine.medical_treatment, coronavirus, lcsh:Medicine, 030204 cardiovascular system & hematology, Lower risk, Article, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Internal medicine, medicine, Factors sexuals en les malalties, 030212 general & internal medicine, Espanya, Mechanical ventilation, business.industry, SARS-CoV-2, Mortality rate, lcsh:R, COVID-19, General Medicine, Intensive care unit, gender differences, Spain, Sex factors in disease, Observational study, Complication, business, Cohort study
Abstract

There is some evidence that male gender could have a negative impact on the prognosis and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aim of the present study was to compare the characteristics of coronavirus disease 2019 (COVID-19) between hospitalized men and women with confirmed SARS-CoV-2 infection. This multicenter, retrospective, observational study is based on the SEMI-COVID-19 Registry. We analyzed the differences between men and women for a wide variety of demographic, clinical, and treatment variables, and the sex distribution of the reported COVID-19 deaths, as well as intensive care unit (ICU) admission by age subgroups. This work analyzed 12,063 patients (56.8% men). The women in our study were older than the men, on average (67.9 vs. 65.7 years; p < 001). Bilateral condensation was more frequent among men than women (31.8% vs. 29.9%; p = 0.007). The men needed non-invasive and invasive mechanical ventilation more frequently (5.6% vs. 3.6%, p < 0.001, and 7.9% vs. 4.8%, p < 0.001, respectively). The most prevalent complication was acute respiratory distress syndrome, with severe cases in 19.9% of men (p < 0.001). In men, intensive care unit admission was more frequent (10% vs. 6.1%; p < 0.001) and the mortality rate was higher (23.1% vs. 18.9%; p < 0.001). Regarding mortality, the differences by gender were statistically significant in the age groups from 55 years to 89 years of age. A multivariate analysis showed that female sex was significantly and independently associated with a lower risk of mortality in our study. Male sex appears to be related to worse progress in COVID-19 patients and is an independent prognostic factor for mortality. In order to fully understand its prognostic impact, other factors associated with sex must be considered.

Published
2021
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4. Palliative Sedation in Patients Hospitalized in Internal Medicine Departments

Author

Díez-Manglano, Jesús, de Isasmendi Pérez, Soledad Isasi, Gómez, Marta Rubio, Pérez, Magdalena Martín, Díez García, Luis Felipe, Maroto, Ignacio Vallejo, Losada, Cristina Ocaña, Roldán, Susana Moya, Pérez, Catalina Díaz, Granado, Javier Caballero, García Font, Resfa María, Jódar Lorente, Francisco J., Vázquez, Gloria Pérez, Expósito, Ana belén Ferro, Amaya González, María Luisa, Antiñolo, Fernando Gamboa, Molina, Álvaro González, Hernández, Mercedes Gómez, García, Marcos Guzmán, León, Lola Benítez, Rivas, Lorena Montero, Mariscal, María Ruiz, Aguirre, Noelia Gómez, González García, María Pilar, Algora, Isabel Martín, Bueno Castel, María Carmen, Laiglesia, Fernando Ruiz, Tello, Esperanza Bejarano, Cabrerizo García, José Luis, Fernández, Nuria Guiral, Camera, Luis, Gauna, Carla, Requejo, Pedro Abad, Gutiérrez, Rocío Martínez, Regueiro, Rebeca Fernández, Sánchez Vidal, María Teresa, Mejido, Joaquín Alfonso, Carús, Enrique García, Calvo Rodríguez, Carmen Elena, García, Paula Martínez, Olivares, Sixto Ruiz, Fullana Barcelo, María Isabel, Arencibia, Carmen González, Vilamajó, Rosa Ros, José Monedero Prieto, María, Becerra, Concepción González, Pérez, Sofía, Plata, Andrea Martín, Chocarro, Raquel Portilla, Gutiérrez, Carlos Dueñas, Álvarez, Francisco Estrada, Balbuena, Sonia Peña, Galindo, Raúl Rodríguez, Cobos Siles, Marta María, Sánchez Muñoz, Luis Ángel, López, Ana Castañón, Lobo, Celia Sanz, Chimeno Viñas, María Montserrat, Contreras Uriel, María Ángeles, Domínguez, Judit Gil, González, Francisco Medrano, Machín Lázaro, José Manuel, Gamboa, Jeffrey Magallanes, Galdeano, Mónica Rodríguez, Giménez, Joaquín Castro, Barberá Farré, José Ramón, Aragón, Raquel Núñez, Torán, Ferrán Masanés, Barbé, José, Farré, Elena Güell, Bonafonte, Olga Torres, Miñana, Ana lozano, Sarabia, Desirée Moras, Pérez, Rosa, Arnau i Fernández, Dolors, Formiga, Francesc, Fernández, Javier Fernández, Salomó, Antoni Castro, Qanneta, Rami, Pardo Ortega, María Victoria, Díaz, Cristina Estrada, Pintado, Yasmina Monterroso, Cors, Montserrat García, Almendros Rivas, María Cruz, Albin, Dolors Domingo, Morera, Jaume Roig, Álvaro, Nuria Galofré, Parodi, Aythami Toro, Sánchez, Mario Loureiro, Acebal, Carla de la Guerra, García, Javier Zubizarreta, Claveras, Iasone Benavente, Cabanes, Juan Martí, Lázaro, Ignacio Sanz, Romero, José Barquero, López-Alegría, Leticia Nevado, Arévalo Lorido, José Carlos, Vales, Emilio Casariego, Lorenzo Vizcaya, Ana María, Rodríguez, Cristina Macía, Fernández, Silvia Pérez, Sánchez, Pascual Sesma, Jiménez-Beatty, María Dolores, Vázquez, Laura González, Hernando, Ángel Brea, Herrero, Jesús Castiella, González Anglada, María Isabel, Gracia Lorenzo, Virginia M., Martín, Alejandro Pérez, Melcón, Gerardo García, Antúnez, María Gómez, Quesada Simón, María Angustias, Gil, Fuensanta Gil, Martínez, María Asenjo, Aragoneses, Lourdes Mancebo, Parra, Jorge Calderón, Pérez, María del Carmen Romero, García, José Curbelo, Cuesta, Fernando Laguna, Segovia Abad, María Eugenia, Ortega, María Fontecha, Martínez, Guillermina Lara, Blanco, Ana Pinos, Fraile, Raquel Rodil, Litago, Elisabel Martínez, Echeverría, Aitziber Echeverría, Valladares, Manuel Priego, Serrano, Carlos Trescoli, Mas, Josep Vicente, Suau, Óscar Torregrosa, Tomás, Eva Gil, Rubio, Rafael Castillo, Murcia Zaragoza, José Manuel, Sánchez, Pilar Román, Herola, Ana García, Tenllado Doblas, Pedro Pablo, Blázquez Encinar, Julio César, Vela, Enrique Castellano, Carrizo, Néstor, Galvañ, Vicente Giner, Roca Villanueva, Bernardino Manuel, Liaño, Francisco Pasquau, Pascual Izuel, José María, Isasi de Isasmendi Pérez, Soledad, García Fenoll, Rosa, Sánchez, Luis Ángel, Formiga, Françesc, Giner Galvañ, Vicente, Dueñas, Carlos, Roca, Bernardino, Estrada Díaz, Cristina, and Casariego Vales, Emilio

Published
2020
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7. GLUCOCOVID: A controlled trial of methylprednisolone in adults hospitalized with COVID-19 pneumonia

Author

Corral-Gudino, Luis, Bahamonde, Alberto, Arnaiz-Revillas, Francisco, Gómez-Barquero, Julia, Abadía-Otero, Jesica, García-Ibarbia, Carmen, Mora, Víctor, Cerezo-Hernández, Ana, Hernández, José L., López-Muñíz, Graciela, Hernández-Blanco, Fernando, Cifrián, Jose M., Olmos, Jose M., Carrascosa, Miguel, Nieto, Luis, Fariñas, María Carmen, Riancho, José A., Buelta-González, Cristina, Marcos-Martínez, Luis A., Martínez-Vidal, Ana I., Dosantos-Gallego, Pilar R.l, Pérez-Sagredo, Jesús, Sandomingo-Freire, Silvia, Muñumer-Blázquez, Rebeca, Paredes-Mogollo, Antonio, Brague-Allegue, Elena, García-Rivero, Juan L., Olmos, José M., Fariñas, Carmen, Cifrian, José M., Hernández, Jose L., Mora, Victor, Nieto, Sara, Ruiz-Cubillán, Juan, Bermúdez, Arancha, Pardo, Javier, Amado, Carlos, Insunza, Andrés, Gil, Aritz, Diaz-Terán, Teresa, Fayos, Marina, Zabaleta, Miguel A., Parra, Juan J., Ruíz-de-Temiño-de-la-Peña, Angela, Arroyo-Domingo, C. Ainhoa, Mena-Martín, Javier, Miramontes-González, Pablo, Jiménez-Masa, Ana E, Pastor-Mancisidor, Luis, Álvaro-de-Castro, Tanía M, Pérez-Panizo, María Cruz, Ruíz-Albi, Tomás, de-la-Colina-Rojo, C Gema, Andrés-Calvo, María, Crespo-Sedano, Andrea, Morejón-Huerta, Begoña, Briongos-Figuero, Laisa S., Frutos-Arriba, Julio F, Pagán-Buzo, Javier, Gabella-Martín, Miriam, Cobos-Siles, Marta, and Gómez-García, Ana

Subjects
ARDS, medicine.medical_specialty, business.industry, medicine.disease, Intensive care unit, law.invention, Pneumonia, Randomized controlled trial, Methylprednisolone, law, Internal medicine, Relative risk, medicine, Breathing, Clinical endpoint, business, medicine.drug
Abstract

BackgroundWe aimed to determine whether a 6-day course of intravenous methylprednisolone (MP) improves outcome in patients with SARS CoV-2 infection at risk of developing Acute Respiratory Distress Syndrome (ARDS).MethodsMulticentric, partially randomized, preference, open-label trial, including adults with COVID-19 pneumonia, impaired gas exchange and biochemical evidence of hyper-inflammation. Patients were assigned to standard of care (SOC), or SOC plus intravenous MP [40mg/12h 3 days, then 20mg/12h 3 days]. The primary endpoint was a composite of death, admission to the intensive care unit (ICU) or requirement of non-invasive ventilation (NIV).ResultsWe analyzed 85 patients (34, randomized to MP; 22, assigned to MP by clinician’s preference; 29, control group). Patients’ age (mean 68±12 yr) was related to outcome. The use of MP was associated with a reduced risk of the composite endpoint in the intention-to-treat, age-stratified analysis (combined risk ratio -RR-0.55 [95% CI 0.33-0.91]; p=0.024). In the per-protocol analysis, RR was 0.11 (0.01-0.83) in patients aged 72 yr or less, 0.61 (0.32-1.17) in those over 72 yr, and 0.37 (0.19-0.74, p=0.0037) in the whole group after age-adjustment by stratification. The decrease in C-reactive protein levels was more pronounced in the MP group (p=0.0003). Hyperglycemia was more frequent in the MP group.ConclusionsA short course of MP had a beneficial effect on the clinical outcome of severe COVID-19 pneumonia, decreasing the risk of the composite end point of admission to ICU, NIV or death.

Published
2020
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10. Respiratory chain polymorphisms and obesity in the Spanish population, a cross-sectional study

Author

de Marco, Griselda, primary, Garcia-Garcia, Ana Barbara, additional, Real, Jose Tomas, additional, Gonzalez-Albert, Veronica, additional, Briongos-Figuero, Laisa-Socorro, additional, Cobos-Siles, Marta, additional, Lago-Sampedro, Ana, additional, Corbaton, Arturo, additional, Teresa Martinez-Larrad, Maria, additional, Carmena, Rafael, additional, Martin-Escudero, Juan Carlos, additional, Rojo-Martínez, Gemma, additional, and Chaves, Felipe Javier, additional

Published
2019
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12. Lo que la diabetes esconde

Author

Gabella-Martín, Miriam, primary, Cobos-Siles, Marta María, additional, Abadía-Otero, Jesica, additional, and Briongos-Figuero, Laisa Socorro, additional

Published
2018
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