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2. Learning for Air Traffic Management: guidelines for future AI systems

Author

Cocchioni, M., Bonelli, S., Westin, Carl, Borst, C., Bång, Magnus, Hilburn, B., Cocchioni, M., Bonelli, S., Westin, Carl, Borst, C., Bång, Magnus, and Hilburn, B.

Abstract

The SESAR-funded Modern ATM via Human / Automation Learning Optimisation (MAHALO) project recently completed two years of technical work exploring the human performance impacts of AI and Machine Learning (ML), as applied to enroute ATC conflict detection and resolution (CD&R). It first developed a hybrid ML CD&R capability, along with a realtime simulation platform and experimental User Interface. After a series of development trials, the project culminated in a pair of field studies (i.e., human-in-the-loop trials) across two EU countries, with a total of 35 operational air traffic controllers. In each of these two field studies, controller behaviour was first captured in a pre-test phase, and used to train the ML system. Subsequent main experiment trials then experimentally manipulated within controllers both Conformance (as either a personalised-, group average-, or optimized model) and Transparency (as ether a baseline vector depiction, an enhanced graphical diagram, or a diagramplus-text presentation). The proposed paper presents guidelines on the design and implementation of ML systems in Air Traffic Control, derived from the results and lesson learned from the Simulations, as well as the qualitative feedback received from the controllers themselves.

Published
2023
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3. [SENTIERI - Epidemiological study of residents in national priority contaminated sites: incidence of mesothelioma]

Author

Binazzi, A, Bruno, C, Comba, P, Conti, S, Corfiati, M, Fazzo, L, Manno, V, Marinaccio, A, Menegozzo, S, Minelli, G, Pasetto, R, Pirastu, R, Zona, A, ANGELILLO, Italo Francesco, Canessa, Pa, Cauzillo, G, Cavone, D, Chellini, E, Cocchioni, M, De Michieli, P, Forastiere, F, Davoli, M, Di Giammarco, A, Gennaro, V, Giaimo, M, Gioffrè, F, Mangone, L, Mazzoleni, G, Mensi, C, Merler, E, Merletti, F, Merseburger, A, Miligi, L, Mirabelli, D, Musti, M, Negro, C, Nicita, C, Pascucci, C, Riboldi, L, Romanelli, A, Schallemberg, G, Stracci, F, Trafficante, L, Tumino, R., Binazzi, A, Bruno, C, Comba, P, Conti, S, Corfiati, M, Fazzo, L, Manno, V, Marinaccio, A, Menegozzo, S, Minelli, G, Pasetto, R, Pirastu, R, Zona, A, Angelillo, Italo Francesco, Canessa, Pa, Cauzillo, G, Cavone, D, Chellini, E, Cocchioni, M, De Michieli, P, Forastiere, F, Davoli, M, Di Giammarco, A, Gennaro, V, Giaimo, M, Gioffrè, F, Mangone, L, Mazzoleni, G, Mensi, C, Merler, E, Merletti, F, Merseburger, A, Miligi, L, Mirabelli, D, Musti, M, Negro, C, Nicita, C, Pascucci, C, Riboldi, L, Romanelli, A, Schallemberg, G, Stracci, F, Trafficante, L, and Tumino, R.

Abstract

The purpose of SENTIERI-ReNaM Project is to describe mesothelioma incidence in the Italian National Priority Contaminated Sites (NPCSs). The present report deals with 39 NPCSs (20 in Northern Italy, 8 in Central Italy and 11 in Southern Italy). Asbestos is specifically mentioned in the regulatory acts of recognition for 10 NPCSs and it is the only agent that has determined environmental contamination in 3 of them (Casale Monferrato, Broni, and Bari). The timeframe of the study is 2000-2011 for 34 out of 39 sites. The corresponding reference periods for the sites of Latium, Campania, Umbria, and Bolzano Province are, respectively, 2001-2011, 2005-2011, and 2006-2011. Standardized Incidence Ratios (SIRs) for mesothelioma, with their corresponding 90% Confidence Intervals, have been estimated for all sites. The interpretation of the study findings has been based on anamnestic information made available by the Italian National Mesothelioma Registry (ReNaM), and completed thanks to knowledge derived from the international scientific literature. In men, mesothelioma incidence has shown excesses in 27/39 sites and defects in the remaining 12; in women, excesses have been reported in 20 sites, defects in 15, and no cases have been detected in the remaining 4 sites. The highest annual incidence rates have been observed in the sites characterized only by the presence of asbestos- cement factories (Broni and Casale Monferrato): respectively, 98.0 and 68.6 per 100,000 per year in men, 72.1 and 45.8 in women. Besides these two sites, the highest rates have been observed in the sites with naval shipyards: 13.2 in men and 2.5 in women. Excesses of mesothelioma incidence have been confirmed (with respect to previous observations) in the sites of Broni, Casale Monferrato, Balangero, and in the coastal areas of Trieste, La Spezia, Venice, and Leghorn. Balangero has been the major European chrysotile quarry, while the other sites are characterized by the presence of naval shipyards with demonstrated use of asbestos before it was banned in 1992. An excess of mesothelioma incidence has also been confirmed in the site of Biancavilla, characterized by the presence of the fluoro-edenite fibrous amphibole, classified as carcinogenic to humans by the International Agency for Research on Cancer (IARC). An increased incidence of mesothelioma was also observed in the areas where no direct use of asbestos had previously been documented, like Cengio and Saliceto (chemical industry), Falconara on Sea (oil refinery), and Litorale Domizio Flegreo and Agro Aversano (a large area including multiple hazardous waste dumping sites). These findings show that a relevant proportion of Italian mesothelioma cases is concentrated in NPCSs. About 1,500 extra cases of mesothelioma have been estimated in the overall series of 39 sites (2000-2011), corresponding to 125 extra cases per year. The excess has concerned the sites with manufacture of asbestos-cement products, but also the areas with asbestos quarries, naval shipyards, illegal hazardous waste dumping sites with asbestos-containing materials, petrochemical industries, refineries and steel plants. In some sites, particularly Casale Monferrato and Broni, analytical epidemiological studies have shown the causal role of not only occupational, but also environmental exposures, with special reference to paving of gardens and courtyards with asbestos-cement industry by-products. The main novelty generated by the collaborative SENTIERI-ReNaM Project concerns the detection of significant mesothelioma excesses not only in sites where asbestos is explicitly reported as a source of contamination, but also in a number of areas defined "of national interest" for environmental cleanup due to other sources of pollution. This confirms that the range of economic activities and working and living environments affected by asbestos exposure is very wide and it is not restricted to the industrial sectors characterized by the direct use of this material.

Published
2016

5. SENTIERI-ReNaM: Valutazione globale del carico di mesotelioma

Author

Binazzi A, GdL SENTIERI-ReNaM., Bruno, C, Comba, PAOLO GIOVANNI, Conti, S, Corfiati, M, Fazzo, L, Manno, V, Marinaccio, A, Menegozzo, S, Minelli, Giuditta, Pasetto, R, Pirastu, R, Zona, A, Angelillo, I, Canessa, Pa, Cauzillo, G, Cavone, D, Chellini, E, Cocchioni, M, De Michieli, P, Forastiere, F, Davoli, M, Di Giammarco, A, Gennaro, V, Giaimo, M, Gioffrè, F, Mangone, L, Mazzoleni, G, Mensi, C, Merler, E, Merletti, F, Merseburger, A, Miligi, L, Mirabelli, D, Musti, M, Negro, C, Nicita, C, Pascucci, C, Riboldi, Lorenzo, Romanelli, A, Schallemberg, G, Stracci, F, Trafficante, Luigi Alberto, and Tumino, R.

Subjects
Mesothelioma, Male, Risk, Epidemiology, Incidence, Asbestos, Burden of illness, Italy, National Priority Contaminated Sites - NPCSs, Carcinogens, Environmental, Confidence Intervals, Female, Health Surveys, Humans, Industry, Occupational Exposure, Registries, Environmental Exposure, Environmental Pollution, Hazardous Waste Sites, Public Health, Environmental and Occupational Health, Environmental and Occupational Health, Environmental, Carcinogens, Public Health
Published
2017

7. La sopravvivenza dei pazienti oncologici in Italia

Author

Coviello, Vincenzo, Buzzoni, Carlotta, Fusco, Mario, Barchielli, Alessandro, Cuccaro, Francesco, De Angelis, Roberta, Giacomin, Adriano, Luminari, Stefano, Randi, Giorgia, Mangone, Lucia, Autelitano M, AIRTUM Working Group., Bizzoco, S, Vercelli, M, Borciani, E, Buzzoni, C, Candela, G, Cocchioni, M, Cremone, L, Crocetti, E, Crosignani, P, Cusimano, R, Dei Tos, A, Falcini, F, Federico, M, Ferretti, S, Fusco, M, Gennaro, V, Giacomin, A, Gola, G, La Rosa, F, Madeddu, A, Magoni, M, Mangone, L, Maspero, S, Mazzoleni, G, Melcarne, A, Merletti, F, Michiara, M, Minerba, S, Pannozzo, F, Piffer, S, Ponz de Leon, M, Quarta, F, Ricci, P, Russo, A, Sampietro, G, Sciacca, S, Sechi, O, Serraino, D, Sutera Sardo, A, Tisano, F, Traina, A, Tumino, R, Usala, M, Vitale, F, Vitarelli, S, and Zanetti, R.

Subjects
Male, Epidemiology, Incidence, Environmental and Occupational Health, Medical Oncology, Survival Rate, Italy, Neoplasms, Female, Humans, Prevalence, Registries, Retrospective Studies, Public Health, Environmental and Occupational Health, Public Health
Published
2017

8. [The contribution of the Italian association of cancer registries (AIRTUM)]

Author

Crocetti, Emanuele, Buzzoni, Carlotta, Autelitano M, AIRTUM Working Group., Bizzoco, S, Bonelli, L, Borciani, E, Buzzoni, C, Candela, G, Cavalieri D'Oro, L, Cocchioni, M, Coviello, V, Cremone, L, Crocetti, E, Dei Tos AP, Falcini, F, Ferretti, S, Fusco, M, Gennaro, V, Giacomin, A, Gola, G, La Rosa, F, Madeddu, A, Magoni, M, Mangone, L, Marchesi, C, Maspero, S, Mazzoleni, G, Melcarne, A, Merletti, F, Michiara, M, Minerba, S, Pannozzo, F, Piffer, S, Ponz de Leon, M, Ricci, P, Russo, A, Sampietro, G, Sciacca, S, Sechi, O, Serraino, D, Sutera Sardo, A, Tagliabue, G, Traina, A, Tumino, R, Usala, M, Vitale, F, Vitarelli, S, and Zanetti, R.

Abstract

The study of cluster requires the ability to identify, with accuracy and completeness, the health events of interest and their geographical location and time of occurrence. For rare and complex diseases, such as childhood cancers, it is possible to observe a significant health migration from the place of residence, which makes the detection even more complex. The best tool to identify these rare diseases is represented by cancer registries (CRs). In fact, CRs collect, through many sources, information related to tumours that arise in the population resident in their areas of activity. The number of the sources of information has increased thanks to the computerization of health services. The availability of multiple sources of information increases the completeness of data collection overcoming the limits of a single source, and makes it possible to describe the diagnostic-therapeutic course and the outcome of the cases. Among all data sources, for childhood cancers the model 1.01, which summarize the clinical information of the cases treated in one of the Italian Association of paediatric haematology and oncology (AIEOP) centres, is relevant. Moreover, CRs produce reliable and comparable data due to the use of international rules and classifications for the definition of the topography and morphology of cancer, for the date of diagnosis, and for quality checks. In Italy, the Italian association of cancer registries (AIRTUM) coordinates the activities of 45 population CRs, both general and specialized (by age or tumour type). AIRTUM involves a population of over 6.7 million citizens under the age of 20 years, approximately 60% of the total resident population. AIRTUM plays a role of coordination, support, and harmonization for Italian CRs through training, accreditation, and a shared database, it promotes and participates in national and international collaboration involving scientific societies (AIEOP, Italian Association of medical oncology - AIOM, Italian Federation of volunteer-based cancer organisations - FAVO) and institutions (Italian national Institute of health, Italian national cancer institute of Milan) and performs analysis on key epidemiological indicators (incidence, mortality, survival, and prevalence). The AIRTUM database contains 19,650 cancer cases in child/ adolescent patients diagnosed from 1967 to 2011. The epidemiology of childhood cancers has been the subject of two AIRTUM monographs published in 2008 and in 2013 in collaboration with AIEOP; the latter includes specific contributions on polluted sites, on the psychological side, and on the experience of the parents of young cancer patients. The collaboration between different professionals, needs, and knowledge is the policy followed by AIRTUM to build up a complete picture of cancer epidemiology, even of childhood cancer, in Italy.

Published
2016

9. Italian cancer figures, report 2014: Prevalence and cure of cancer in Italy

Author

Adamo, M., Alessi, D., Aletta, P., Amodio, R., Andreone, S., Angelin, T., Anghinoni, E., Annulli, M., Arciprete, C., Artioli, M., Autelitano, M., Baili, P., Balducci, C., Baracco, M., Baracco, S., Battisti, W., Bella, F., Bellatalla, C., Bellini, A., Belluardo, C., Benatti, P., Benedetto, G., Benfatto, L., Bernazza, E., Bianconi, F., Biavati, P., Bidoli, E., Birri, S., Bizzoco, S., Bonelli, L., Bonini, A., Borciani, E., Bordini, M., Bovo, E., Bozzani, F., Braghiroli, B., Brucculeri, M., Brunori, V., Bucalo, G., Bucchi, L., Bugliarello, E., Bulatko, A., Busco, S., Busso, P., Buzzoni, C., Calabrese, A., Calabretta, L., Caldarella, A., Candela, G., Cannone, G., Canu, L., Caparelli, M., Capocaccia, R., Cappelletti, M., Caprara, L., Carboni, D., Carletti, N., Caroli, S., Cascio, M., Cascone, G., Casella, C., Castaing, M., Cavalieri, D., L, Cecconami, L., Celesia, M., Cena, T., Cercato, M., Cesaraccio, R., Chiesa, R., Cirilli, C., Cocchioni, M., Codazzi, T., Cogno, R., Colamartini, A., Colanino, Z., A, Cometti, I., Contiero, P., Contrino, M., Corbinelli, A., Cordaro, C., Corti, M., Costa, A., Costarelli, D., Coviello, V., Crapanzano, G., Cremone, L., Crocetti, E., Cuccaro, F., Curatella, S., Cusimano, R., D Alò, D., Dal, C., Dal, T., Cin, A., Dal, M., Davini, C., Dottori, D., De, M., Angelis, R., Santis, D., De, E., Valiere, E., Dei, T., Demurtas, G., Devigili, E., Felice, D., Di, E., Grazia, L., Gregorio, D., Di, C., Norcia, R., Prima, D., Dinaro, Y., Distefano, R., Doa, N., Domati, F., Fabiano, S., Facchinelli, G., Falcini, F., Falk, M., Fanetti, A., Fattoruso, S., Federico, M., Ferrari, F., Ferrari, L., Ferretti, S., Fidelbo, M., Filipazzi, L., Fiore, A., Fiori, G., Foca, F., Forgiarini, O., Foschi, R., Francisci, S., Frasca, G., Frassoldi, E., Fusco, M., Gada, D., Garrone, E., Gasparotti, C., Gatta, G., Gatti, L., Gaudiano, C., Gennaro, V., Gentilini, M., Gerevini, C., Ghilardi, S., Ghisleni, S., Giacomin, A., Giavazzi, L., Gigli, A., Gilardi, F., Giorgetti, S., Giorgi, R., P, Giubelli, C., Giuliani, O., Giurdanella, M., Gola, G., Goldoni, C., Golizia, M., Greco, A., Guarda, L., Guttadauro, A., Guzzinati, S., Iachetta, F., Iannelli, A., Ieni, A., Intrieri, T., Kaleci, S., Rosa, L., F, Lando, C., Lavecchia, A., Lazzarato, F., Rose, L., Leone, A., Leone, R., Lonati, F., Lucchi, S., Luminari, S., Macci, L., Macerata, V., Madeddu, A., Maffei, S., Maghini, A., Magnani, C., Magnani, G., Magoni, M., Mallone, S., Mameli, G., Mancini, S., Mancuso, P., Mangone, L., Manneschi, G., Mannino, R., Mannino, S., Marani, E., Marchesi, C., Mariani, F., Martorana, C., Marzola, L., Maspero, S., Maule, M., Mazzei, A., Mazzoleni, G., Mazzucco, G., Melcarne, A., Merletti, F., Merlo, E., Michiara, M., Migliari, E., Minerba, S., Minicuzzi, A., Mizzi, M., Monetti, D., Morana, G., Moroni, E., Mosso, M., Muni, A., Mura, F., Natali, M., Negrino, L., Nemcova, L., Nicita, C., Ocello, C., Pala, F., Palumbo, M., Panciroli, E., Panico, M., Pannozzo, F., Pascucci, C., Pasolini, A., Pastore, G., Patriarca, S., Pedroni, M., Perrotta, C., Pesce, P., Petrinelli, A., Petrucci, C., Pezzarossi, A., Pezzuto, L., Piffer, S., Pinon, M., Antonio Pinto, Pintori, N., Pirani, M., Pirino, D., Pironi, V., Ponz, D., Leon, M., Prandi, R., Prazzoli, R., Puleio, M., Puppo, A., Quarta, F., Quattrocchi, M., Ramazzotti, V., Rashid, I., Ravaioli, A., Ravazzolo, B., Ravegnani, M., Reggiani Bonetti, L., Ricci, P., Rinaldi, E., Rizzello, R., Rognoni, M., Rollo, P., Roncaglia, F., Roncucci, L., Rosano, A., Rossi, F., Rossi, G., Rossi, M., Rossi, S., Rossini, S., Rosso, S., Rudisi, G., Ruggeri, M., Russo, A., Russo, M., Sacchettini, C., Sacchetto, L., Sacco, G., Sacerdote, C., Salvatore, S., Salvi, O., Sampietro, G., Santucci, C., Scheibel, M., Sciacca, S., Sciacchitano, C., Sciacchitano, S., Scuderi, T., Sechi, O., Seghini, P., Senatore, G., Serafini, G., Serraino, D., Sgargi, P., Sini, G., Sobrato, I., Soddu, M., Solimene, C., Spano, F., Spata, E., Sperduti, I., Spinosa, S., Staiti, R., Stocco, C., Stracci, F., Sunseri, R., Sutera, S., Tagliabue, G., Tamburo, L., Tamburrino, S., Taranto, V., Terracini, B., Tisano, F., Tittarelli, A., Tognazzo, S., Torrisi, A., Traina, A., Trama, A., Trapani, C., Tschugguel, B., Tumino, R., Usala, M., Vacirca, S., Valerio, O., Valla, K., Varvarà, M., Vasquez, E., Vassante, B., Vattiato, R., Vercelli, M., Vercellino, P., Vicentini, M., Villa, M., Virdone, S., Francesco Vitale, Vitale, M., Vitali, B., Vitali, M., Vitarelli, S., Zanchi, A., Zanetti, R., Zani, G., Zanier, L., Zappa, M., Zarcone, M., Zevola, A., Zorzi, M., Zucchetto, A., Zucchi, A., Adamo, MS, Alessi, D, Aletta, P, Amodio, R, Andreone, S, Angelin, T, Anghinoni, E, Annulli, ML, Arciprete, C, Artioli, ME, Autelitano, M, Baili, P, Balducci, C, Baracco, M, Baracco, S, Battisti, W, Bella, F, Bellatalla, C, Bellini, A, Belluardo, C, Benatti, P, Benedetto, G, Benfatto, L, Bernazza, E, Bianconi, F, Biavati, P, Bidoli, E, Birri, S, Bizzoco, S, Bonelli, L, Bonini, A, Borciani, E, Bordini, M, Bovo, E, Bozzani, F, Braghiroli, B, Brucculeri, MA, Brunori, V, Bucalo, G, Bucchi, L, Bugliarello, E, Bulatko, A, Busco, S, Busso, P, Buzzoni, C, Calabrese, A, Calabretta, L, Caldarella, A, Candela, G, Cannone, G, Canu, L, Caparelli, M, Capocaccia, R, Cappelletti, M, Caprara, L, Carboni, D, Carletti, N, Caroli, S, Cascio, MA, Cascone, G, Casella, C, Castaing, M, Cavalieri, d'Oro, L, Cecconami, L, Celesia, MV, Cena, T, Cercato, MC, Cesaraccio, R, Chiesa, R, Cirilli, C, Cocchioni, M, Codazzi, T, Cogno, R, Colamartini, A, Colanino, Ziino, A, Cometti, I, Contiero, P, Contrino, ML, Corbinelli, A, Cordaro, C, Corti, M, Costa, A, Costarelli, D, Coviello, V, Crapanzano, G, Cremone, L, Crocetti, E, Cuccaro, F, Curatella, S, Cusimano, R, D'Alò, D, Dal, Cappello, T, Dal, Cin, A, Dal, Maso, L, Davini, C, De, Dottori, M, De, Angelis, R, De, Santis, E, De, Valiere, E, Dei, Tos, AP, Demurtas, G, Devigili, E, Di, Felice, E, di, Grazia, L, Di, Gregorio, C, di, Norcia, R, Di, Prima, A, Dinaro, Y, Distefano, R, Doa, N, Domati, F, Fabiano, S, Facchinelli, G, Falcini, F, Falk, M, Fanetti, AC, Fattoruso, S, Federico, M, Ferrari, F, Ferrari, L, Ferretti, S, Fidelbo, M, Filipazzi, L, Fiore, AR, Fiori, G, Foca, F, Forgiarini, O, Foschi, R, Francisci, S, Frasca, G, Frassoldi, E, Fusco, M, Gada, D, Garrone, E, Gasparotti, C, Gatta, G, Gatti, L, Gaudiano, C, Gennaro, V, Gentilini, MA, Gerevini, C, Ghilardi, S, Ghisleni, S, Giacomin, A, Giavazzi, L, Gigli, A, Gilardi, F, Giorgetti, S, Giorgi, Rossi, P, Giubelli, C, Giuliani, O, Giurdanella, MC, Gola, G, Goldoni, CA, Golizia, MG, Greco, A, Guarda, L, Guttadauro, A, Guzzinati, S, Iachetta, F, Iannelli, A, Ieni, A, Intrieri, T, Kaleci, S, La, Rosa, F, Lando, C, Lavecchia, AM, Lazzarato, F, Le, Rose, L, Leone, A, Leone, R, Lonati, F, Lucchi, S, Luminari, S, Macci, L, Macerata, V, Madeddu, A, Maffei, S, Maghini, A, Magnani, C, Magnani, G, Magoni, M, Mallone, S, Mameli, G, Mancini, S, Mancuso, P, Mangone, L, Manneschi, G, Mannino, R, Mannino, S, Marani, E, Marchesi, C, Mariani, F, Martorana, C, Marzola, L, Maspero, S, Maule, M, Mazzei, A, Mazzoleni, G, Mazzucco, G, Melcarne, A, Merletti, F, Merlo, E, Michiara, M, Migliari, E, Minerba, S, Minicuzzi, A, Mizzi, M, Monetti, D, Morana, G, Moroni, E, Mosso, ML, Muni, A, Mura, F, Natali, M, Negrino, L, Nemcova, L, Nicita, C, Ocello, C, Pala, F, Palumbo, M, Panciroli, E, Panico, M, Pannozzo, F, Pascucci, C, Pasolini, A, Pastore, G, Patriarca, S, Pedroni, M, Perrotta, C, Pesce, P, Petrinelli, AM, Petrucci, C, Pezzarossi, A, Pezzuto, L, Piffer, S, Pinon, M, Pinto, A, Pintori, N, Pirani, M, Pirino, D, Pironi, V, Ponz, de, Leon, M, Prandi, R, Prazzoli, R, Puleio, M, Puppo, A, Quarta, F, Quattrocchi, M, Ramazzotti, V, Rashid, I, Ravaioli, A, Ravazzolo, B, Ravegnani, M, Reggiani-Bonetti, L, Ricci, P, Rinaldi, E, Rizzello, R, Rognoni, M, Rollo, PC, Roncaglia, F, Roncucci, L, Rosano, A, Rossi, F, Rossi, G, Rossi, M, Rossi, S, Rossini, S, Rosso, S, Rudisi, G, Ruggeri, MG, Russo, AG, Russo, M, Sacchettini, C, Sacchetto, L, Sacco, G, Sacerdote, C, Salvatore, S, Salvi, O, Sampietro, G, Santucci, C, Scheibel, M, Sciacca, S, Sciacchitano, C, Sciacchitano, S, Scuderi, T, Sechi, O, Seghini, P, Senatore, G, Serafini, G, Serraino, D, Sgargi, P, Sini, GM, Sobrato, I, Soddu, M, Solimene, C, Spano, F, Spata, E, Sperduti, I, Spinosa, S, Staiti, R, Stocco, C, Stracci, F, Sunseri, R, Sutera, Sardo, A, Tagliabue, G, Tamburo, L, Tamburrino, S, Taranto, V, Terracini, B, Tisano, F, Tittarelli, A, Tognazzo, S, Torrisi, A, Traina, A, Trama, A, Trapani, C, Tschugguel, B, Tumino, R, Usala, M, Vacirca, S, Valerio, O, Valla, K, Varvarà, M, Vasquez, E, Vassante, B, Vattiato, R, Vercelli, M, Vercellino, PC, Vicentini, M, Villa, M, Virdone, S, Vitale, F, Vitale, MF, Vitali, B, Vitali, ME, Vitarelli, S, Zanchi, A, Zanetti, R, Zani, G, Zanier, L, Zappa, M, Zarcone, M, Zevola, A, Zorzi, M, Zucchetto, A, and Zucchi, A

Subjects
Aged, 80 and over, Male, Medicine (all), Aged, Female, Humans, Italy, Middle Aged, Neoplasms, Prevalence, Registries, Survival Rate, Socio-culturale, Settore MED/42 - Igiene Generale E Applicata, 80 and over, cancer prevalence, cancer incidence, cancer in Italy
Abstract

This Report intends to estimate the total number of people still alive in 2010 after cancer diagnosis in Italy, regardless of the time since diagnosis, and to project these estimates to 2015. This study is also aimed to estimate the number of already cured cancer patients, whose mortality rates have become undistinguishable from that of the general population of the same age and sex.The study took advantage of the information from the AIRTUM database, which included 29 Cancer Registries (covering 21 million people, 35% of the Italian population). A total of 1,624,533 cancer cases diagnosed between 1976 and 2009 contributed to the study. For each registry, the observed prevalence was calculated. Prevalence for lengths of time exceeding the maximum duration of the registration and of the complete prevalence were derived by applying an estimated correction factor, the completeness index. This index was estimated by means of statistical regression models using cancer incidence and survival data available in registries with 18 years of observation or more. For 50 types or combinations of neoplasms, complete prevalence was estimated at 1.1.2010 as an absolute number and as a proportion per 100,000 inhabitants by sex, age group, area of residence, and years since diagnosis. Projections of complete prevalence for 1.1.2015 were computed under the assumption of a linear trend of the complete prevalence observed until 2010. Validated mixture cure models were used to estimate: the cure fraction, that is the proportion of patients who, starting from the time of diagnosis, are expected to reach the same mortality rate of the general population; the conditional relative survival (CRS), that is the cumulative probability of surviving some additional years, given that patients already survived a certain number of years; the time to cure, that is the number of years necessary so that conditional survival in the following five years (5-year CRS) exceeds the conventional threshold of 95% (i.e., mortality rates in cancer patients become undistinguishable compared to those of the general population); the proportion of patients already cured, i.e., people alive since a number of years exceeding time to cure.As of 1.1.2010, it was estimated that 2,587,347 people were alive after a cancer diagnosis, corresponding to 4.4% of the Italian population. A relevant geographical heterogeneity emerged, with a prevalence above 5% in northern registries and below 4% in southern areas. Men were 45% of the total (1,154,289) and women 55% (1,433,058). In the population aged 75 years or more, the proportions of prevalent cases were 20% in males and 13% in females, 11% between 60 and 74 years of age in both sexes. Nearly 600,000 Italian women were alive after a breast cancer diagnosis (41% of all women with this neoplasm), followed by women with cancers of the colon rectum (12%), corpus uteri (7%), and thyroid (6%). In men, 26% of prevalent cases (295,624) were patients with prostate cancer, 16% with either bladder or colon rectum cancer. The projections for 1.1.2015 are of three million (3,036,741) people alive after a cancer diagnosis, 4.9% of the Italian population; with a 20% increase for males and 15% for females, compared to 2010. The cure fractions were heterogeneous according to cancer type and age. Estimates obtained as the sum of cure fractions for all cancer types showed that more than 60% of patients diagnosed below the age of 45 years will reach the same mortality rate of the general population. This proportion decreased with increasing age and it was30% for cancer diagnosed after the age of 74 years. It was observed that 60% of all prevalent cases (1,543,531 people or 2.6% of overall Italian population) had been diagnosed5 years earlier (long-term survivors). Time to cure (5-year CRS95%) was reached in10 years by patients with cancers of the stomach, colon rectum, pancreas, corpus and cervix uteri, brain, and Hodgkin lymphoma. Mortality rates similar to the ones reported by the general population were reached after approximately 20 years for breast and prostate cancer patients. Five-year CRS remained95% for25 years after cancer diagnosis in patients with liver and larynx cancers, non-Hodgkin lymphoma, myeloma, and leukaemia. Time to cure was reached by 27% (20% in men and 33% in women) of all people living after a cancer diagnosis, defined as already cured.The study showed a steady increase over time (nearly +3% per year) of prevalent cases in Italy. A quarter of Italian cancer patients alive in 2010 can be considered as already cured. The AIRTUM Report 2014 describes characteristics of cancer patients and former-patients for 50 cancer types or combinations by sex and age. This detailed information promotes the conduction of studies aimed at expanding the current knowledge on the quality of life of these patients during and after the active phase of treatments (prevalence according to health status), on the long-term effects of treatments (in particular for paediatric patients), on the cost profile of cancer patients, and on rare tumours. All these observations have a high potential impact on health planning, clinical practice, and, most of all, patients' perspective.

Published
2014

10. In 2014 cancer registration covers more than half of the Italian population [Nel 2014 la registrazione dei tumori in Italia è estesa a oltre la metà del Paese]

Author

Crocetti, E, Madeddu, A, Mangone, L, AIRTUM Working Group: : Autelitano, M, Bizzoco, S, Bonelli, L, Borciani, E, Buzzoni, C, Candela, G, Cavalieri D'Oro, L, Cocchioni, M, Coviello, V, Cremone, L, Cusimano, R, Dei Tos, A, Falcini, F, Ferretti, S: Fusco, M, Gennaro, V, Giacomin, A, Gola, G, La Rosa, F, Magoni, M, Marchesi, C, Maspero, S, Mazzoleni, G, Melcarne, A, Merletti, F, Michiara, M, Minerba, S, Pannozzo, F, Piffer, S, Ponz de Leon, M, Quarta, F, Ricci, P, Russo, A, Sampietro, G, Sciacca, S, Sechi, O, Serraino, D, Sutera Sardo, A, Tagliabue, G: Tisano, F, Traina, A, Tumino, R, Usala, M, VITALE, Francesco, Vitarelli, S, Zanetti, R., Crocetti, E, Madeddu, A, Mangone, L, AIRTUM Working Group: : Autelitano, M, Bizzoco, S, Bonelli, L, Borciani, E, Buzzoni, C, Candela, G, Cavalieri D'Oro, L, Cocchioni, M, Coviello, V, Cremone, L, Cusimano, R, Dei Tos, A, Falcini, F, Ferretti, S: Fusco, M, Gennaro, V, Giacomin, A, Gola, G, La Rosa, F, Magoni, M, Marchesi, C:, Maspero, S, Mazzoleni, G, Melcarne, A, Merletti, F, Michiara, M, Minerba, S, Pannozzo, F, Piffer, S, Ponz de Leon, M, Quarta, F, Ricci, P, Russo, A, Sampietro, G, Sciacca, S, Sechi, O, Serraino, D, Sutera Sardo, A, Tagliabue, G: Tisano, F, Traina, A, Tumino, R, Usala, M, Vitale, F, Vitarelli, S, and Zanetti, R.

Subjects
cancer incidence, Italian population, cancer registration, Settore MED/42 - Igiene Generale E Applicata
Published
2014

11. After the increasing trend in the Nineties, in Italy incidence of tumours in children (0-14 years) is decreasing [Dopo l'aumento registrato negli anni Novanta, in Italia l'incidenza dei tumori infantili (0-14 anni) è in diminuzione]

Author

Buzzoni, C, Ferretti, S, Dal Maso, L, AIRTUM Working Group: Autelitano, M, Bizzoco, S, Vercelli, M, Borciani, E, Candela, G, Cocchioni, M, Cremone, L, Crocetti, E, Crosignani, P, Cusimano, R, Dei Tos, A, Falcini, F, Federico, M, Fusco, M, Gennaro, V, Giacomin, A, Gola, G, La Rosa, F, Madeddu, A, Magoni, M, Mangone, L, Maspero, S, Mazzoleni, G, Melcarne, A, Merletti, F, Michiara, M, Minerba, S, Pannozzo, F, Piffer, S, Ponz de Leon, M, Quarta, F, Ricci, P, Russo, A, Sampietro, G, Sciacca, S, Sechi, O, Serraino, D, Sutera Sardo, A, Tisano, F, Traina, A, Tumino, R, Usala, M, VITALE, Francesco, Vitarelli, S, Zanetti, R., Buzzoni, C, Ferretti, S, Dal Maso, L, AIRTUM Working Group: Autelitano, M, Bizzoco, S, Vercelli, M, Borciani, E, Candela, G, Cocchioni, M, Cremone, L, Crocetti, E, Crosignani, P, Cusimano, R, Dei Tos, A, Falcini, F, Federico, M, Fusco, M, Gennaro, V, Giacomin, A, Gola, G, La Rosa, F, Madeddu, A, Magoni, M, Mangone, L, Maspero, S, Mazzoleni, G, Melcarne, A, Merletti, F, Michiara, M, Minerba, S, Pannozzo, F, Piffer, S, Ponz de Leon, M, Quarta, F, Ricci, P, Russo, A, Sampietro, G, Sciacca, S, Sechi, O, Serraino, D, Sutera Sardo, A, Tisano, F, Traina, A, Tumino, R, Usala, M, Vitale, F, Vitarelli, S, and Zanetti, R

Subjects
cancer incidence, Tumours in children, tumours in children in italy, Settore MED/42 - Igiene Generale E Applicata
Published
2014

12. In the last 15 years, survival in Italian children (0-14 years) is increased to 12%. [Negli ultimi 15 anni la sopravvivenza per tumore nei bambini italiani di età 0-14 anni è aumentata del 12%]

Author

Fusco, M, Trama, A, Buzzoni, C, AIRTUM Working G.r.o.u.p. Collaborators: Autelitano, M, Bizzoco, S, Vercelli, M, Borciani, E, Candela, G, Cocchioni, M, Cremone, L, Crocetti, E, Crosignani, P, Cusimano, R, Dei Tos, A, Falcini, F, Federico, M, Ferretti, S, Gennaro, V, Giacomin, A, Gola, G, La Rosa, F, Madeddu, A, Magoni, M, Mangone, L, Maspero, S, Mazzoleni, G, Melcarne, A, Merletti, F, Michiara, M, Minerba, S, Pannozzo, F, Piffer, S, Ponz de Leon, M, Quarta, F, Ricci, P, Russo, A, Sampietro, G, Sciacca, S, Sechi, O, Serraino, D, Sutera Sardo, A, Tisano, F, Traina, A, Tumino, R, Usala, M, VITALE, Francesco, Vitarelli, S, Zanetti, R., Fusco, M, Trama, A, Buzzoni, C, AIRTUM Working Group. Collaborators: Autelitano, M, Bizzoco, S, Vercelli, M, Borciani, E, Candela, G, Cocchioni, M, Cremone, L, Crocetti, E, Crosignani, P, Cusimano, R, Dei Tos, A, Falcini, F, Federico, M, Ferretti, S, Gennaro, V, Giacomin, A, Gola, G, La Rosa, F, Madeddu, A, Magoni, M, Mangone, L, Maspero, S, Mazzoleni, G, Melcarne, A, Merletti, F, Michiara, M, Minerba, S, Pannozzo, F, Piffer, S, Ponz de Leon, M, Quarta, F, Ricci, P, Russo, A, Sampietro, G, Sciacca, S, Sechi, O, Serraino, D, Sutera Sardo, A, Tisano, F, Traina, A, Tumino, R, Usala, M, Vitale, F, Vitarelli, S, and Zanetti, R.

Subjects
descriptive study, children survival, Settore MED/42 - Igiene Generale E Applicata, survival
Published
2014

14. [SENTIERI-ReNaM: Discussion and concluding remarks]

Author

Zona, Amerigo, Fazzo, Lucia, Binazzi, Alessandra, Bruno, Caterina, Corfiati, Marisa, Comba, Pietro, Conti, Susanna, Menegozzo, Simona, Nicita, Carmela, Pasetto, Roberto, Pirastu, Roberta, Marinaccio, Alessandro, Binazzi A, GdL SENTIERI-ReNaM., Bruno, C, Comba, P, Conti, S, Corfiati, M, Fazzo, L, Manno, V, Marinaccio, A, Menegozzo, S, Minelli, G, Pasetto, R, Pirastu, R, Zona, A, Angelillo, I, Canessa, Pa, Cauzillo, G, Cavone, D, Chellini, E, Cocchioni, M, De Michieli, P, Forastiere, F, Davoli, M, Di Giammarco, A, Gennaro, V, Giaimo, M, Gioffrè, F, Mangone, L, Mazzoleni, G, Mensi, C, Merler, E, Merletti, F, Merseburger, A, Miligi, L, Mirabelli, D, Musti, M, Negro, C, Nicita, C, Pascucci, C, Riboldi, L, Romanelli, A, Schallemberg, G, Stracci, F, Trafficante, L, and Tumino, R.

Subjects
Male, Mesothelioma, Risk, Incidence, Asbestos, Environmental Exposure, Health Surveys, Carcinogens, Environmental, Environmental, Italy, Occupational Exposure, Hazardous Waste Sites, Carcinogens, Confidence Intervals, Humans, Industry, Female, Registries, Environmental Pollution
Abstract

SENTIERI-ReNaM Project analysed the incidence of malignant mesothelioma (MM) for the period 2000-2011 in 39 National Priority Contaminated Sites (NPCSs), and assessed the overall impact of mesothelioma in different types of NPCSs. In the study period, 2,683 incident cases of malignant mesothelioma were recorded: 1,998 males (74.5%), 685 females (25.5%). Excluding cases with non attributable exposure and those non interviewed, exposure was identified in 1,926 cases (70% of all cases): 1,541 males (occupational exposure: 1,414; environmental exposure: 82), 385 females (occupational exposure: 103; environmental exposure: 141). Women experienced mainly environmental and domestic exposures to asbestos. Standard Incidence Ratio (SIR) excesses were observed in men in 27 out of 39 NPCSs and defects in the remaining 12; in women, 20 NPCSs showed SIR excesses, defects in 15; in 4 NPCSs no MM cases occurred among female population. The highest rates were found in NPCSs with asbestos-cement plants (Broni and Casale Monferrato), respectively, 98 per 100,000 per year and 68.6 in men, 72.1 and 45.8 in women. Excluding these two sites, the highest incidence rates were found in the group with harbours and shipyards, where the rates were, respectively, 13.2 among men and 2.5 among women. The results of this report will be communicated to national and local institutions, as well as to NPCSs resident populations.

Published
2016

15. [Hodgkin lymphoma in Italian children and adolescents]

Author

Dal Maso, Luigino, Terracini, Benedetto, Mosso, MARIA LUISA, Buzzoni, Carlotta, Autelitano M, AIRTUM Working Group., Bizzoco, S, Bonelli, L, Borciani, E, Buzzoni, C, Candela, G, Cavalieri D'Oro, L, Cocchioni, M, Coviello, V, Cremone, L, Crocetti, E, Dei Tos AP, Falcini, F, Ferretti, S, Fusco, M, Gennaro, V, Giacomin, A, Gola, G, La Rosa, F, Madeddu, A, Magoni, M, Mangone, L, Marchesi, C, Maspero, S, Mazzoleni, G, Melcarne, A, Merletti, F, Michiara, M, Minerba, S, Pannozzo, F, Piffer, S, Ponz de Leon, M, Ricci, P, Russo, A, Sampietro, G, Sciacca, S, Sechi, O, Serraino, D, Sutera Sardo, A, Tagliabue, G, Traina, A, Tumino, R, Usala, M, Vitale, F, Vitarelli, S, and Zanetti, R.

Subjects
Aged, 80 and over, Adult, Male, Adolescent, Incidence, Infant, Newborn, Infant, Middle Aged, Newborn, Prognosis, Hodgkin Disease, Survival Rate, Age Distribution, Italy, Risk Factors, Child, Preschool, 80 and over, Humans, Female, Aged, Child, Retrospective Studies, Sex Distribution, Preschool
Published
2016

16. AIRTUM - Italia 2015: 3 milioni di italiani vivono dopo una diagnosi di tumore, ma incidenza e mortalità sono in calo

Author

Dal Maso, Luigino, Buzzoni, Carlotta, Guzzinati, Stefano, Crocetti, Emanuele, Autelitano M, AIRTUM Working Group., Bizzoco, S, Bonelli, L, Borciani, E, Buzzoni, C, Candela, G, Cavalieri D'Oro, L, Cocchioni, M, Coviello, V, Cremone, L, Crocetti, E, Dei Tos, A, Falcini, F, Ferretti, Silvia, Fusco, Marco, Gennaro, V, Giacomin, A, Gola, GIAN LUIGI, La Rosa, F, Madeddu, A, Magoni, M, Mangone, L, Marchesi, C, Maspero, S, Mazzoleni, G, Melcarne, Alessandro, Merletti, F, Michiara, M, Minerba, S, Pannozzo, F, Piffer, S, Ponz de Leon, M, Ricci, Paola, Russo, A, Sampietro, G, Sciacca, S, Sechi, O, Serraino, D, Sutera Sardo, A, Tagliabue, G, Traina, A, Tumino, R, Usala, M, Vitale, F, Vitarelli, S, and Zanetti, R.

Subjects
Adult, Male, Epidemiology, Incidence, Environmental and Occupational Health, Middle Aged, Aged, Disease-Free Survival, Female, Humans, Italy, Neoplasms, Registries, Risk Factors, Sex Distribution, Survival Rate, Public Health, Environmental and Occupational Health, Public Health
Published
2016

17. ITALIAN CANCER FIGURES - REPORT 2015: The burden of rare cancers in Italy = I TUMORI IN ITALIA - RAPPORTO 2015: I tumori rari in Italia

Author

Busco, Susanna, Buzzoni, Carlotta, Mallone, Sandra, Trama, Annalisa, Castaing, Marine, Bella, Francesca, Amodio, Rosalba, Bizzoco, Sabrina, Cassetti, Tiziana, Cirilli, Claudia, Cusimano, Rosanna, De Angelis, Roberta, Fusco, Mario, Gatta, Gemma, Gennaro, Valerio, Giacomin, Adriano, Giorgi Rossi, Paolo, Mangone, Lucia, Mannino, Salvatore, Rossi, Silvia, Pierannunzio, Daniela, Tavilla, Andrea, Tognazzo, Sandro, Tumino, Rosario, Vicentini, Massimo, Vitale, Maria Francesca, Crocetti, Emanuele, Dal Maso, Luigino, Mazzoleni, G, Bulatko, A, Devigili, E, Tschugguel, B, De Valiere, E, Facchinelli, G, Falk, M, Vittadello, F, Coviello, V, Cuccaro, F, Calabrese, A, Pinto, A, Cannone, G, Vitali, Me, Sampietro, G, Ghisleni, S, Giavazzi, L, Zanchi, A, Zucchi, A, Giacomin, A, Vercellino, Pc, Andreone, S, Fedele, M, Barale, A, Germinetti, F, Magoni, M, Zani, G, Salvi, O, Puleio, M, Gerevini, C, Adorni, A, Chiesa, R, Lonati, F, Tumino, R, Cascone, G, Frasca, G, Giurdanella, Mc, Martorana, C, Morana, G, Nicita, C, Rollo, Pc, Ruggeri, Mg, Spata, E, Vacirca, S, Sciacca, S, Sciacchitano, C, Fidelbo, M, Paderni, F, Benedetto, G, Vasquez, E, Bella, F, Calabretta, L, Castaing, M, Di Prima, A, Ieni, A, Leone, A, Pesce, P, Sciacchitano, S, Torrisi, A, Varvarà, M, Sutera Sardo, A, Mazzei, A, Lavecchia, Am, Mancuso, P, Nocera, V, Gola, G, Corti, M, Grandi, L, Caparelli, M, Mannino, S, Belluardo, C, Bizzoco, S, Davini, C, Lucchi, S, Villa, M, Anghinoni, E, Di Norcia, R, Ferretti, S, Biavati, P, Marzola, L, Migliari, E, Carletti, N, Petrucci, C, Brosio, F, Piccinni, L, Valente, N, Barchielli, A, Buzzoni, C, Caldarella, A, Corbinelli, A, Di Dia PP, Intrieri, T, Manneschi, G, Nemcova, L, Susini, N, Visoli, C, Zappa, M, Serraino, D, Angelin, T, Bidoli, E, Birri, S, Dal Maso, L, De Dottori, M, De Santis, E, Forgiarini, O, Zucchetto, A, Zanier, L, Filiberti, Ra, Casella, C, Marani, E, Puppo, A, Celesia, Mv, Cogno, R, Garrone, E, Pannozzo, F, Busco, S, Rashid, I, Ramazzotti, V, Cercato, Mc, Natali, M, Battisti, W, Sperduti, I, Macci, L, Bugliarello, E, Bernazza, E, Tamburo, L, Rossi, M, Curatella, S, Tamburrino, S, Fattoruso, S, Valerio, O, Melcarne, A, Quarta, F, Golizia, Mg, Raho, Am, De Maria, V, Vitarelli, S, Ricci, P, Guarda, L, Gatti, L, Pironi, V, Pasolini, A, Bordini, M, Autelitano, M, Ghilardi, S, Leone, R, Filipazzi, L, Bonini, A, Giubelli, C, Russo, Ag, Quattrocchi, M, Distefano, R, Panciroli, E, Bellini, A, Pinon, M, Spinosa, S, Spagnoli, G, Goldoni, Ca, Valla, K, Braghiroli, B, Cirilli, C, Donini, M, Amendola, V, Cavalieri d'Oro, L, Rognoni, M, Le Rose, L, Merlo, E, Negrino, L, Pezzuto, L, Fusco, M, Bellatalla, C, Panico, M, Perrotta, C, Vassante, B, Vitale, Mf, Usala, M, Pala, F, Sini, Gm, Pintori, N, Canu, L, Demurtas, G, Doa, N, Vitale, F, Cusimano, R, Traina, A, Guttadauro, A, Cascio, Ma, Mannino, R, Ravazzolo, B, Brucculeri, Ma, Rudisi, G, Adamo, Ms, Amodio, R, Costa, A, Zarcone, M, Sunseri, R, Bucalo, G, Trapani, C, Staiti, R, Michiara, M, Bozzani, F, Sgargi, P, Borciani, E, Seghini, P, Faccini, F, Prazzoli, R, Mangone, L, Di Felice, E, Pezzarossi, A, Caroli, S, Sacchettini, C, Ferrari, F, Roncaglia, F, Vicentini, M, Falcini, F, Colamartini, A, Bucchi, L, Balducci, C, Ravegnani, M, Vitali, B, Cordaro, C, Caprara, L, Giuliani, O, Giorgetti, S, Palumbo, M, Vattiato, R, Ravaioli, A, Mancini, S, Caiazzo, Al, Cavallo, R, Colavolpe, Af, D'Alessandro, A, Iannelli, A, Lombardo, C, Senatore, G, Sensi, F, Cesaraccio, R, Sechi, O, Pirino, D, Mura, F, Contrino, Ml, Madeddu, A, Tisano, F, Muni, A, Dinaro, Y, Mizzi, M, Sacco, G, Aletta, P, Ziino, Ac, Maspero, S, Fanetti, Ac, Moroni, E, Cometti, I, Annulli, Ml, Cecconami, L, Minerba, S, Minicuzzi, A, Zanetti, R, Rosso, S, Patriarca, S, Prandi, R, Sobrato, I, Gilardi, F, Busso, P, Sacchetto, L, Candela, G, Scuderi, T, Crapanzano, G, Taranto, V, Piffer, S, Gentilini, Ma, Rizzello, R, Cappelletti, M, Stracci, F, D'Alò, D, Scheibel, M, Costarelli, D, Spano, F, Rossini, S, Santucci, C, Petrinelli, Am, Solimene, C, Bianconi, F, Brunori, V, Tagliabue, G, Contiero, P, Tittarelli, A, Fabiano, S, Maghini, A, Codazzi, T, Frassoldi, E, Gada, D, di Grazia, L, Ruzza, Mr, Dei Tos AP, Baracco, M, Baracco, S, Bovo, E, Dal Cin, A, Fiore, Ar, Greco, A, Guzzinati, S, Monetti, D, Rosano, A, Stocco, C, Tognazzo, S, Zorzi, M, Merletti, F, Magnani, C, Pastore, G, Terracini, B, Alessi, D, Cena, T, Lazzarato, F, Macerata, V, Maule, M, Mosso, Ml, Sacerdote, C, Cocchioni, M, Pascucci, C, Ponz de Leon, M, Domati, F, Rossi, G, Kaleci, S, Rossi, F, Benatti, P, Roncucci, L, Di Gregorio, C, Magnani, G, Pedroni, M, Maffei, S, Mariani, F, Reggiani-Bonetti, L, Gennaro, V, Benfatto, L, Lando, C, Mazzucco, G, Romanelli, A, Storchi, C, Sala, O, Gabbi, C, and Buzzoni, C.

Published
2016

18. [SENTIERI-ReNaM: Results]

Author

Binazzi, Alessandra, Zona, Amerigo, Marinaccio, Alessandro, Bruno, Caterina, Corfiati, Marisa, Fazzo, Lucia, Menegozzo, Simona, Nicita, Carmela, Pasetto, Roberto, Pirastu, Roberta, De Santisi, Marco, Comba, Pietro, Binazzi A, GdL SENTIERI-ReNaM., Bruno, C, Comba, PAOLO GIOVANNI, Conti, S, Corfiati, M, Fazzo, L, Manno, V, Marinaccio, A, Menegozzo, S, Minelli, G, Pasetto, R, Pirastu, R, Zona, A, Angelillo, I, Canessa, Pa, Cauzillo, G, Cavone, D, Chellini, E, Cocchioni, M, De Michieli, P, Forastiere, F, Davoli, M, Di Giammarco, A, Gennaro, V, Giaimo, M, Gioffrè, F, Mangone, L, Mazzoleni, G, Mensi, C, Merler, E, Merletti, F, Merseburger, A, Miligi, L, Mirabelli, D, Musti, M16, 17 Negro, C, Nicita, C, Pascucci, C, Riboldi, L, Romanelli, A, Schallemberg, G, Stracci, F, Trafficante, L, and Tumino, R.

Subjects
Male, Mesothelioma, Risk, Incidence, Asbestos, Environmental Exposure, Health Surveys, Carcinogens, Environmental, Environmental, Italy, Occupational Exposure, Hazardous Waste Sites, Carcinogens, Confidence Intervals, Humans, Industry, Female, Registries, Environmental Pollution
Abstract

Mesothelioma incidence has been analyzed in National Priority Contaminated Sites (NPCSs) to estimate the health impact of asbestos exposure on resident people. The burden of professional and environmental exposures has been identified through data of the Regional Operational Centres (CORs), made available by the Italian National Mesothelioma Registry (ReNaM). An excess of mesothelioma incidence is confirmed in sites with a known past history of direct use of asbestos, such as Balangero, Casale Monferrato, Broni, Bari-Fibronit, and in coastal areas, where shipyards, harbours and other industries that involved a wide use of asbestos are represented (e.g., Trieste, La Spezia, Venice, and Leghorn). An excess of mesothelioma has been observed in settings where the asbestos is not mentioned as contaminant in the decree that included these sites among NPCSs, such as Cengio and Saliceto in Northern Italy; Falconara Marittima and the Bacino Idrografico Fiume Sacco in the Central Italy; the Litorale Domizio Flegreo and Agro Aversano, Milazzo, and Gela in the Southern Italy. Observed excess in the various NPCSs confirms the large-scale occurrence in contaminated Italian sites of a significant amount of total mesothelioma cases observed at national level. The analysis of occupational risk in epidemiological studies with an ecological design helps in defining the contribution of different factors to the overall risk.

Published
2016

20. About 1,400 new cancer diagnosis in Italian children (0-14 years) are attended every year (7,000 in 5 years) [Ogni anno sono previste circa 1.400 nuove diagnosi di tumori maligni nei bambini italiani di età 0-14 anni (7.000 nel quinquennio)]

Author

Crocetti, E, Rondelli, R, Dal Maso, L, AIRTUM Working G.r.o.u.p. Collaborators: Autelitano, M, Bizzoco, S, Vercelli, M, Borciani, E, Buzzoni, C, Candela, G, Cocchioni, M, Cremone, L, Crosignani, P, Cusimano, R, Dei Tos, A, Falcini, F, Federico, M, Ferretti, S, Fusco, M, Gennaro, V, Giacomin, A, Gola, G, La Rosa, F, Madeddu, A, Magoni, M, Mangone, L, Maspero, S, Mazzoleni, G, Melcarne, A, Merletti, F, Michiara, M, Minerba, S, Pannozzo, F, Piffer, S, Ponz de Leon, M, Quarta, F, Ricci, P, Russo, A, Sampietro, G, Sciacca, S, Sechi, O, Serraino, D, Sutera Sardo, A, Tisano, Traina, A, Tumino, R, Usala, M, VITALE, Francesco, Vitarelli, S, Zanetti, R., Crocetti, E, Rondelli, R, Dal Maso, L, AIRTUM Working Group. Collaborators: Autelitano, M, Bizzoco, S, Vercelli, M, Borciani, E, Buzzoni, C, Candela, G, Cocchioni, M, Cremone, L, Crosignani, P, Cusimano, R, Dei Tos, A, Falcini, F, Federico, M, Ferretti, S, Fusco, M, Gennaro, V, Giacomin, A, Gola, G, La Rosa, F, Madeddu, A, Magoni, M, Mangone, L, Maspero, S, Mazzoleni, G, Melcarne, A, Merletti, F, Michiara, M, Minerba, S, Pannozzo, F, Piffer, S, Ponz de Leon, M, Quarta, F, Ricci, P, Russo, A, Sampietro, G, Sciacca, S, Sechi, O, Serraino, D, Sutera Sardo, A, Tisano, Traina, A, Tumino, R, Usala, M, Vitale, F, Vitarelli, S, and Zanetti, R.

Subjects
cancer incidence, cancer in italian children, Settore MED/42 - Igiene Generale E Applicata, cancer in children
Published
2013

22. [Cancer survival in Italy in 2000-2007 is better than in Europe]

Author

Buzzoni, Carlotta, Crocetti, Emanuele, De Angelis, Roberta, Dal Maso, Luigino, Autelitano M, AIRTUM Working Group., Bizzoco, S, Bonelli, L, Borciani, E, Buzzoni, C, Candela, G, Cavalieri D'Oro, L, Cocchioni, M, Coviello, V, Cremone, L, Crocetti, E, Dei Tos, A, Falcini, F, Ferretti, S, Fusco, M, Gennaro, V, Giacomin, A, Gola, G, La Rosa, F, Madeddu, A, Magoni, M, Mangone, L, Marchesi, C, Maspero, S, Mazzoleni, G, Melcarne, A, Merletti, F, Michiara, M, Minerba, S, Pannozzo, F, Piffer, S, Ponz de Leon, M, Ricci, P, Russo, A, Sampietro, G, Sciacca, S, Sechi, O, Serraino, D, Sutera Sardo, A, Tagliabue, G, Traina, A, Tumino, R, Usala, M, Vitale, F, Vitarelli, S, and Zanetti, R.

Subjects
Adult, Europe, Male, Survival Rate, Italy, Neoplasms, Female, Humans, Registries, Retrospective Studies
Published
2015

23. [AIRTUM and SIE for a shared definition of haemolymphopoietic cancers]

Author

Torrisi, Antonina, Castaing, Marine, Giacomin, Adriano, Luminari, Stefano, Mangone, Lucia, Autelitano, M, Bizzoco, S, Bonelli, L, Borciani, E, Buzzoni, C, Candela, G, Cavalieri D'Oro, L, Cocchioni, M, Coviello, V, Cremone, L, Crocetti, E, Dei Tos, A, Falcini, F, Ferretti, S, Fusco, M, Gennaro, V, Giacomin, A, Gola, G, La Rosa, F, Madeddu, A, Magoni, M, Mangone, L, AIRTUM Working Group, Marchesi, C, Maspero, S, Mazzoleni, G, Melcarne, A, Merletti, F, Michiara, M, Minerba, S, Pannozzo, F, Piffer, S, Ponz de Leon, M, Ricci, P, Russo, A, Sampietro, G, Sciacca, S, Sechi, O, Serraino, D, Sutera Sardo, A, Tagliabue, G, Traina, A, Tumino, R, Usala, M, Vitale, F, Vitarelli, S, and Zanetti, R.

Subjects
Societies, Scientific, Italy, Risk Factors, Humans, Population Surveillance, Public Health, Registries, Risk Assessment, Sicily, Hematologic Neoplasms, Scientific, Societies
Published
2015

24. Low prevalence of Corynebacterium Diphtheriae carriers in Italian schoolchildren

Author

Bergamini M., Bonanni P., Cocchioni M., Gabutti G., Giammanco G., Gregorio P., Marin V., Zotti C., Crovari P., The Collaborative Study Group, Bartolozzi C., Pesavento G., Grappasonni I., De Grandi F., Di Tommaso M., Gabutti P., Raso R., DE DONNO, Maria Antonella, GUIDO, Marcello, Bergamini, M., Bonanni, P., Cocchioni, M., DE DONNO, Maria Antonella, Gabutti, G., Giammanco, G., Gregorio, P., Marin, V., Zotti, C., Crovari, P., The Collaborative Study, Group, Bartolozzi, C., Pesavento, G., Grappasonni, I., Guido, Marcello, De Grandi, F., Di Tommaso, M., Gabutti, P., and Raso, R.

Subjects
C. diphtheriae carrier, Diphtheria immunity
Abstract

In Italy, the prevalence of Corynebacterium diphtheriae carriage is unknown. Throat swabs from 1970 healthy chil- dren, 6 to 14 years of age, were investigated. Three non-toxi- genic strains of Corynebacterium diphtheriae biotype mitis, were isolated from as many healthy children. Molecular char- acterization of the these strains indicates that they have been persisting for at least 25 years and are endemic rather than having been imported from countries with current endemic or epidemic diphtheria. Although non-toxigenic strains of C. diphtheriae occurring in the community are usually thought to be of little or no epidemiological importance, it may be possible to convert a non-toxigenic diphtheria strain into a toxigenic one by lysogenization with a specific temperate bacteriophage. Despite the virtual elimination of diphtheria in Italy, this long-standing circulation of non-toxigenic C. diphtheriae poses a potentially significant risk to public health and could result in the re-emergence of diphtheria in our country, even though the high proportion of younger population with protective levels of immunity is probably significant in preventing diphtheria spread. Therefore, it is important to maintain mandatory vaccination in childhood and to offer periodical re-vaccination of adults.

Published
2005

25. Cancer incidence in Italian contaminated sites

Author

Comba, Pietro, Ricci, Paolo, Iavarone, Ivano, Pirastu, Roberta, Buzzoni, Carlotta, Fusco, Mario, Ferretti, Stefano, Fazzo, Lucia, Pasetto, Roberto, Zona, Amerigo, Crocetti, Emanuele, Autelitano, M., Beccaloni, E., Benedetti, M., Benfatto, L., Biggeri, A., Binazzi, Alice, Bianconi, F., Bidoli, E., Bruno, C., Candela, G., Carere, M., Catelan, D., Cocchioni, M., Conti, S., Corfiati, M., Coviello, E., Cremone, L., Dei Tos, A. P., De Santis, M., Falcini, F., Falleni, F., Federico, M., Giacomin, A., Gola, G., Grisotto, L., Guzzinati, S., La Rosa, F., Lillini, L., Madeddu, A., Magoni, M., Mangone, L., Manno, V., Marcello, I., Marinaccio, A., Marsili, G., Maspero, S., Maule, M., Mazzoleni, G., Merletti, F., Minelli, GIAN MARIA, Minerba, A., Michiara, M., Nicita, C., Pannozzo, Francesca, Piccardi, Andrea, Piffer, Stefano, Pisani, P., Santoro, M., Scaini, F., Sciacca, S., Sechi, O., Serraino, D., Soggiu, M. E., Stracci, F., SUTERA SARDO, Alessandro, Tagliabue, G., Tisano, F., Usala, M., Vercelli, M., Vitale, F., Vitarelli, S., and Zambon, P.

Subjects
Contaminated sites, Cancer incidence, Environmental pollution, Public Health, Environmental and Occupational Health
Published
2014

27. [Survival for all cancers is increasing, especially in men, but only thanks to PSA]

Author

Coviello, E, Rashid, I, Buzzoni, C, Fusco, M, Bisanti, L, Sechi, O, Candela, G, Crosignani, P, De Lisi, V, Donato, A, Mangoni, M, Falcini, F, Federico, Massimo, Gennaro, V, Giacomin, A, La Rosa, F, Madeddu, A, Contrino, Ml, Mangone, L, Mazzoleni, G, Pannozzo, F, Zanetti, R, Cocchioni, M, Piffer, S, Pisani, P, PONZ DE LEON, Maurizio, Ricci, P, Serraino, D, Sutera, A, Tessandori, R, Traina, A, Tumino, R, Usala, M, Vercelli, M, Vitarelli, S, Zambon, P, Crocetti, E, Ferretti, S, Gola, G, and Sciacca, S.

Subjects
Male, Survival Rate, PSA, Sex Factors, Italy, Neoplasms, prostate cancer survival, Humans, Prostatic Neoplasms, Female, Prostate-Specific Antigen, survival
Published
2013

28. [About 1,400 new cancer diagnosis in Italian children (0-14 years) are attended every year (7,000 in 5 years)]

Author

Crocetti, E, Rondelli, R, Dal Maso, L, AIRTUM Working Group, Autelitano, M, Bizzoco, S, Vercelli, M, Borciani, E, Buzzoni, C, Candela, G, Cocchioni, M, Cremone, L, Crosignani, P, Cusimano, R, Dei Tos, A, Falcini, F, Federico, M, Ferretti, S, Fusco, M, Gennaro, V, Giacomin, A, Gola, G, La Rosa, F, Madeddu, A, Magoni, M, Mangone, L, Maspero, S, Mazzoleni, G, Melcarne, A, Merletti, Franco, Michiara, M, Minerba, S, Pannozzo, F, Piffer, S, Ponz de Leon, M, Quarta, F, Ricci, P, Russo, A, Sampietro, G, Sciacca, S, Sechi, O, Serraino, D, Sutera Sardo, A, Tisano, F, Traina, A, Tumino, R, Usala, M, Vitale, F, Vitarelli, S, and Zanetti, R.

Subjects
Time Factors, Adolescent, Italy, children, Child, Preschool, Neoplasms, Infant, Newborn, Humans, Infant, Cancer diagnosis, children, Cancer diagnosis, Child
Published
2013

29. Lung cancer incidence in young women (20-49 years) reached incidence in young men

Author

Maso, Dal, Luigino, Autelitano, M, Bizzoco, S, Vercelli, M, Borciani, E, Buzzoni, C, Candela, G, Cocchioni, M, Cremone, L, Crocetti, E, Crosignani, P, Cusimano, R, Dei Tos, A, Falcini, F, Federico, Massimo, Ferretti, S, Fusco, M, Gennaro, V, Giacomin, A, Gola, G, La Rosa, F, Madeddu, A, Magoni, M, Mangone, L, Maspero, S, Mazzoleni, G, Melcarne, A, Merletti, F, Michiara, M, Minerba, S, Pannozzo, F, Piffer, S, PONZ DE LEON, Maurizio, Quarta, F, Ricci, P, Russo, A, Sampietro, G, Sciacca, S, Sechi, O, Serraino, D, Sutera Sardo, A, Tisano, F, Traina, A, Tumino, R, Usala, M, Vitale, F, Vitarelli, S, Zanetti, R., Dal Maso, L, and AIRTUM Working Group Collaborators, including Vitale, F.

Subjects
Male, Lung Neoplasms, cancro nelle giovani donne, young, Incidence, Adenocarcinoma, Lung cancer, incidence, young, cancro nei giovani uomini, Settore MED/42 - Igiene Generale E Applicata, incidenza del ca polmonare, Italy, incidence, Humans, Female, Lung cancer
Abstract

Il grafico, basato sui dati AIRTUM 1992- 2007,mostra l’andamento dell’incidenza di tumore del polmone nei giovani adulti di età 20-49 anni in entrambi i sessi. I

Published
2013

30. Alti tassi di vaccinazione antidifterica e bassa prevalenza di portatori di C. diphtheriae. Risultati di uno studio policentrico effettuato su campioni significativi di alunni della scuola dell'obbligo

Author

Bergamini, Mauro, Bonanni, P., Castagnari, L., Cocchioni, M., De Donno, A., Di Tommaso, S., Gabutti, Giovanni, Gabutti, P., Grappasonni, I., Lonostro, A., Raso, R., Marin, V., Zotti, C., Giammanco, G., Crovari, P., Bergamini, M, Bonanni, P, Castagnari, L, Cocchioni, M, DE DONNO, Maria Antonella, DI TOMMASO, S, Gabutti, G, Gabutti, P, Grappasonni, I, Lonostro, A, Raso, R, Marin, V, Zotti, C, Giammanco, G, and Crovari, P.

Published
2000

31. [Population ageing effect on number of cancer cases: Italian cancer registries data]

Author

Buzzoni, C, Bisanti, L, Budroni, M, Candela, G, Crosignani, P, De Lisi, V, Donato, A, Donato, F, Falcini, F, Federico, Massimo, Fusco, M, Gennaro, V, Giacomin, A, La Rosa, F, Madeddu, A, Contrino, Ml, Mangone, L, Mazzoleni, G, Pannozzo, F, Pascucci, C, Cocchioni, M, Piffer, S, Pisani, P, PONZ DE LEON, Maurizio, Ricci, P, Serraino, D, Sutera, A, Tessandori, R, Traina, A, Tumino, R, Usala, M, Vercelli, M, Vitarelli, S, Zambon, P, Zanetti, R, Crocetti, E, Paci, E, and Ferretti, S.

Subjects
Adult, Aged, 80 and over, Male, Adolescent, Incidence, Population Dynamics, Infant, Newborn, Infant, registries, Middle Aged, Young Adult, Age Distribution, Italy, age, Child, Preschool, Neoplasms, age, cancer, registries, Humans, cancer, Female, Disease Susceptibility, Registries, Child, Aged
Abstract

To describe causes of cancer incidence increase. We identified and quantified a population ageing factor, a factor due to incidence trend of cancer sites with early-diagnosis interventions and a remainder factor (concerning all other cancer sites).We calculated incidence rates for two calendar period (1993-95 and 2003-05).We used data from Cancer Registries with at least one incidence year available for each period (jointly for males and female). We compared crude and age-adjusted rates by the direct method for prostate cancer, breast cancer, colorectal cancer, melanoma of the skin cancer, thyroid cancer, group of other cancer sites and for all cancer sites (but non-melanoma skin cancer).Since 1993-95 to 2003-05 all cancer crude incidence rates have been increasing 17.9% (from 555.4 cases for 100,000 inhabitants/years to 654.8). If population age structure had remained the same, rates would have increased only 6.6% (from 555.4 to 592.0): almost 2/3 of observed increasing are due to population ageing. The remainder part of the increasing is due to incidence trend of cancer sites with early-diagnosis interventions (that anticipates the diagnosis).This study helps to quantify the incidence increase due to population ageing and the raise due to trend of cancer sites with early-diagnosis interventions.

Published
2011

32. Italian cancer figures, report 2011: Survival of cancer patients in Italy

Author

Fusco, M, Buzzoni, C, Coviello, E, Rashid, I, Bianconi, F, Cuccaro, F, Castaing, M, De Angelis, R, Giacomin, A, Guzzinati, S, Mosso, Ml, Pisani, P, Quaglia, A, Randi, G, Ramazzotti, V, Russo, A, Senatore, G, Stracci, F, Traina, A, Vercelli, M, Zarcone, M, Ferretti, S, Mazzoleni, G, Bellú, F, Tschugguel, B, De Valiere, E, Facchinelli, G, Falk, M, Dal Cappello, T, Vercellino, Pc, Andreone, S, Busato, A, Marzola, L, Migliari, E, Carletti, N, Nenci, I, Crocetti, E, Caldarella, A, Corbinelli, A, Giusti, F, Intrieri, T, Manneschi, G, Nemcova, L, Romeo, G, Sacchettini, C, Zappa, M, Paci, E, Serraino, D, Angelin, T, Bidoli, E, Dal Maso, L, de Dottori, M, De Paoli, A, De Santis, E, Forgiarini, O, Lise, M, Zucchetto, A, Zanier, L, Orengo, Ma, Casella, C, Marani, E, Puppo, A, Celesia, Mv, Cogno, R, Manenti, S, Garrone, E, Pannozzo, F, Busco, S, Cercato, Mc, Battisti, W, Sperduti, I, Macci, L, Bugliarello, E, Bernazza, E, Tamburo, L, Rossi, M, Curatella, S, De Francesco, C, Tamburrino, S, Bisanti, L, Autelitano, M, Ghilardi, S, Leone, R, Filipazzi, L, Bonini, A, Giubelli, C, Federico, M, Artioli, Me, Valla, K, Braghiroli, B, Cirilli, C, Luminari, S, Pirani, M, Ferrari, L, Bellatalla, C, Panico, M, Perrotta, C, Vassante, B, Vitale, Mf, Michiara, M, Bozzani, F, Sgargi, P, Tumino, R, La Rosa MG, Cascone, G, Frasca, G, Giurdanella, Mc, Martorana, C, Morana, G, Nicita, C, Rollo, Pc, Ruggeri, Mg, Sigona, A, Spata, E, Vacirca, S, Mangone, L, Di Felice, E, Pezzarossi, A, Caroli, S, Pellegri, C, Vicentini, M, Storchi, C, Cavuto, S, Costa, J, Falcini, F, Colamartini, A, Bucchi, L, Balducci, C, Ravegnani, M, Vitali, B, Cordaro, C, Caprara, L, Giuliani, O, Giorgetti, S, Salvatore, S, Palumbo, M, Vattiato, R, Ravaioli, A, Foca, F, Rinaldi, E, Mancini, S, Tonelli, C, Amadori, M, Cremone, L, Iannelli, A, Zevola, A, Budroni, M, Cesaraccio, R, Pirino, D, Carboni, D, Fiori, G, Soddu, M, Mameli, G, Mura, F, Contrino, Ml, Madeddu, A, Tisano, F, Sciacca, S, Muni, A, Mizzi, M, Russo, M, Sacco, G, Aletta, P, Colanino Ziino, A, Tessandori, R, Fanetti, Ac, Maspero, S, Annulli, Ml, Moroni, E, Sanoja Gonzalez ME, Zanetti, R, Rosso, S, Patriarca, S, Prandi, R, Sobrato, I, Gilardi, F, Busso, P, Piffer, S, Gentilini, Ma, Battisti, L, Rizzello, R, Cappelletti, M, Moser, M, La Rosa, F, D'Alò, D, Scheibel, M, Costarelli, D, Spano, F, Rossini, S, Santucci, C, Petrinelli, Am, Solimene, C, Brunori, V, Crosignani, P, Tagliabue, G, Contiero, P, Preto, L, Tittarelli, A, Maghini, A, Codazzi, T, Frassoldi, E, Gada, D, Costa, E, di Grazia, L, Zambon, P, Baracco, M, Bovo, E, Dal Cin, A, Fiore, Ar, Greco, A, Monetti, D, Rosano, A, Stocco, C, Tognazzo, S, Donato, Francesco, Limina, Rosa Maria, Adorni, A, Andreis, P, Zani, G, Piovani, F, Salvi, O, Puleio, M, Vitarelli, S, Antonini, S, Candela, G, Pappalardo, G, Scuderi, T, Lottero, B, Ribaudo, M, Ricci, P, Guarda, L, Gatti, L, Bozzeda, A, Dall'Acqua, M, Pironi, V, Sutera Sardo, A, Mazzei, A, Sirianni, N, Lavecchia, Am, Mancuso, P, Usala, M, Pala, F, Sini, Gm, Pintori, N, Canu, L, Demurtas, G, Doa, N, Ponz de Leon, M, Domati, F, Rossi, G, Goldoni, Ca, Rossi, F, De Gaetani, C, Benatti, P, Roncucci, L, Di Gregorio, C, Pedroni, M, Pezzi, A, Maffei, S, Mariani, F, Borsi, E, Carruba, G, Cusimano, R, Amodio, R, Dolcemascolo, C, Staiti, R, Pastore, G, Magnani, C, Terracini, B, Cena, T, Alessi, D, Baussano, I, Merletti, F, Maule, M, Macerata, V, Cocchioni, M, Pascucci, C, Gennaro, V, Lazzarotto, A, Benfatto, L, Mazzucco, G, and Montanaro, F.

Subjects
Survival, Italy, cancer patients
Published
2011

33. Utilizzo di un questionario come strumento di confrontabilità tra un registro tumori di popolazione (RT) e il registro regionale specializzato dei Mesoteliomi (COR)

Author

Nicita, C., Chellini, E, Buzzoni, C, Caldarella, A, Giovannetti, L, Intrieri, T, Martini, A, Mensi, C., Tisano, F., Auteliano, M, Bisanti, L, Candela, G, Cappelletti, M, Cirilli, C, Contrino, Ml, F, Donato, Francesco, Falcini, F, Ferretti, S, Fusco, M, Giacomin, A, La Rosa, F, Limina, Rosa Maria, Madeddu, A, Mangone, L, Michiara, Am, Pannozzo, F, Piffer, S, Ricci, P, Serraino, D, Tessandori, R, Tumino, R, Vercelli, M, Vitarelli, S, Zambon, P, Zanetti, R, Cavone, D, Cocchioni, M, Consonni, D, De Zotti, R, Forastiere, F, Gennaro, V, Marinaccio, A, Menegozzo, M, Merletti, F, Mirabelli, D, Musti, M, Pascucci, C, Romanelli, A, Schallenberg, G, and Tumino, R.

Subjects
registro tumori di popolazione, Questionario, registro regionale specializzato dei Mesoteliomi
Published
2011

34. Italian cancer figures: North and South are getting closer

Author

Buzzoni, C, Bisanti, L, Budroni, M, Candela, G, Crosignani, P, De Lisi, V, Donato, A, Donato, F, Falcini, F, Federico, Massimo, Fusco, M, Gennaro, V, Giacomin, A, La Rosa, F, Madeddu, A, Contrino, Ml, Mangone, L, Mazzoleni, G, Pannozzo, F, Pascucci, C, Cocchioni, M, Piffer, S, Pisani, P, PONZ DE LEON, Maurizio, Ricci, P, Serraino, D, Sutera, A, Tessandori, R, Traina, A, Tumino, R, Usala, M, Vercelli, M, Vitarelli, S, Zambon, P, Zanetti, R, Crocetti, E, and Ferretti, S.

Subjects
Male, Italy, Socioeconomic Factors, Neoplasms, Humans, Female, Cancer
Published
2011

35. I tumori in Italia. Rapporto 2011: La sopravvivenza dei pazienti oncologici in Italia

Author

Fusco M, Airtum Working G. R. O. U. P., Buzzoni, C., Coviello, E., Rashid, I., Bianconi, F., Cuccaro, F., Castaing, M., Angelis, R., Giacomin, A., Guzzinati, S., Mosso, Ml, Pisani, P., Quaglia, A., Randi, G., Ramazzotti, V., Russo, A., Senatore, G., Stracci, F., Traina, A., Vercelli, M., Zarcone, M., Ferretti, S., Mazzoleni, G., Bellú, F., Tschugguel, B., Valiere, E., Facchinelli, G., Falk, M., Dal Cappello, T., Vercellino, Pc, Andreone, S., Busato, A., Marzola, L., Migliari, E., Carletti, N., Nenci, I., Crocetti, E., Caldarella, A., Corbinelli, A., Giusti, F., Intrieri, T., Manneschi, G., Nemcova, L., Romeo, G., Sacchettini, C., Zappa, M., Paci, E., Serraino, D., Angelin, T., Bidoli, E., Dal Maso, L., Dottori, M., Paoli, A., Santis, E., Forgiarini, O., Lise, M., Zucchetto, A., Zanier, L., Orengo, Ma, Casella, C., Marani, E., Puppo, A., Celesia, Mv, Cogno, R., Manenti, S., Garrone, E., Pannozzo, F., Busco, S., Cercato, Mc, Battisti, W., Sperduti, I., Macci, L., Bugliarello, E., Bernazza, E., Tamburo, L., Rossi, M., Curatella, S., Francesco, C., Tamburrino, S., Bisanti, L., Autelitano, M., Ghilardi, S., Leone, R., Filipazzi, L., Bonini, A., Giubelli, C., Federico, Massimo, Artioli, Me, Valla, K., Braghiroli, B., Cirilli, C., stefano luminari, Pirani, M., Ferrari, L., Bellatalla, C., Fusco, M., Panico, M., Perrotta, C., Vassante, B., Vitale, Mf, Michiara, M., Bozzani, F., Sgargi, P., Tumino, R., La Rosa MG, Cascone, G., Frasca, G., Giurdanella, Mc, Martorana, C., Morana, G., Nicita, C., Rollo, Pc, Ruggeri, Mg, Sigona, A., Spata, E., Vacirca, S., Mangone, L., Di Felice, E., Pezzarossi, A., Caroli, S., Pellegri, C., Vicentini, M., Storchi, C., Cavuto, S., Costa, J., Falcini, F., Colamartini, A., Bucchi, L., Balducci, C., Ravegnani, M., Vitali, B., Cordaro, C., Caprara, L., Giuliani, O., Giorgetti, S., Salvatore, S., Palumbo, M., Vattiato, R., Ravaioli, A., Foca, F., Rinaldi, E., Mancini, S., Tonelli, C., Amadori, M., Cremone, L., Iannelli, A., Zevola, A., Budroni, M., Cesaraccio, R., Pirino, D., Carboni, D., Fiori, G., Soddu, M., Mameli, G., Mura, F., Contrino, Ml, Madeddu, A., Tisano, F., Sciacca, S., Muni, A., Mizzi, M., Russo, M., Sacco, G., Aletta, P., Colanino Ziino, A., Tessandori, R., Fanetti, Ac, Maspero, S., Annulli, Ml, Moroni, E., Sanoja Gonzalez ME, Zanetti, R., Rosso, S., Patriarca, S., Prandi, R., Sobrato, I., Gilardi, F., Busso, P., Piffer, S., Gentilini, Ma, Battisti, L., Rizzello, R., Cappelletti, M., Moser, M., La Rosa, F., D Alò, D., Scheibel, M., Costarelli, D., Spano, F., Rossini, S., Santucci, C., Petrinelli, Am, Solimene, C., Brunori, V., Crosignani, P., Tagliabue, G., Contiero, P., Preto, L., Tittarelli, A., Maghini, A., Codazzi, T., Frassoldi, E., Gada, D., Costa, E., Di Grazia, L., Zambon, P., Baracco, M., Bovo, E., Dal Cin, A., Fiore, Ar, Greco, A., Monetti, D., Rosano, A., Stocco, C., Tognazzo, S., Donato, F., Limina, Rm, Adorni, A., Andreis, P., Zani, G., Piovani, F., Salvi, O., Puleio, M., Vitarelli, S., Antonini, S., Candela, G., Pappalardo, G., Scuderi, T., Lottero, B., Ribaudo, M., Ricci, P., Guarda, L., Gatti, L., Bozzeda, A., Dall Acqua, M., Pironi, V., Sutera Sardo, A., Mazzei, A., Sirianni, N., Lavecchia, Am, Mancuso, P., Usala, M., Pala, F., Sini, Gm, Pintori, N., Canu, L., Demurtas, G., Doa, N., Maurizio Ponz de Leon, Domati, Federica, Rossi, Giuseppina, Goldoni, Ca, Rossi, F., Gaetani, C., Piero Benatti, Luca Roncucci, Di Gregorio, C., Pedroni, Monica, Pezzi, A., Maffei, Stefania, Mariani, Francesco, Borsi, E., Carruba, G., Cusimano, R., Amodio, R., Dolcemascolo, C., Staiti, R., Pastore, G., Magnani, C., Terracini, B., Cena, T., Alessi, D., Baussano, I., Merletti, F., Maule, M., Macerata, V., Cocchioni, M., Pascucci, C., Gennaro, V., Lazzarotto, A., Benfatto, L., Mazzucco, G., and Montanaro, F.

Subjects
Survival, cancer
Published
2011

39. Italian cancer figures, report 2012: Cancer in children and adolescents

Author

Pisani, P, Buzzoni, C, Crocetti, E, Maso, L, Rondelli, R, Alessi, D, Aricò, M, Bidoli, E, Ferrari, A, Fusco, M, Gatta, G, Guzzinati, S, Jankovic, M, Locatelli, F, Maule, M, Mosso, M, Pastore, G, Pession, A, Rashid, I, Sacerdote, C, Terracini, B, Tognazzo, S, Trama, A, Ferretti, S, Porta, F, Mazzoleni, G, Tschugguel, B, De Valiere, E, Facchinelli, G, Falk, M, Cappello, T, Giacomin, A, Vercellino, P, Andreone, S, Marzola, L, Migliari, E, Carletti, N, Nenci, I, Caldarella, A, Corbinelli, A, Intrieri, T, Manneschi, G, Nemcova, L, Ocello, C, Sacchettini, C, Zappa, M, Paci, E, Serraino, D, Angelin, T, Birri, S, De Dottori, M, De Santis, E, Forgiarini, O, Zucchetto, A, Zanier, L, Vercelli, M, Orengo, M, Casella, C, Marani, E, Puppo, A, Celesia, M, Cogno, R, Levrieri, I, Manenti, S, Garrone, E, Quaglia, A, Pannozzo, F, Busco, S, Ramazzotti, V, Cercato, M, Battisti, W, Sperduti, I, Macci, L, Bugliarello, E, Valerio, O, Bernazza, E, Tamburo, L, Rossi, M, Curatella, S, Tamburrino, S, Fattoruso, S, Bisanti, L, Autelitano, M, Cuccaro, F, Randi, G, Ghilardi, S, Leone, R, Filipazzi, L, Bonini, A, Giubelli, C, Federico, M, Artioli, M, Valla, K, Braghiroli, B, Cirilli, C, Luminari, S, Pirani, M, Ferrari, L, Bellatalla, C, Panico, M, Perrotta, C, Vassante, B, Vitale, M, Michiara, M, Bozzani, F, Sgargi, P, Tumino, R, Rosa, M, Cascone, G, Frasca, G, Giurdanella, M, Martorana, C, Morana, G, Nicita, C, Rollo, P, Ruggeri, M, Sigona, A, Spata, E, Vacirca, S, Mangone, L, Di Felice, E, Pezzarossi, A, Caroli, S, Pellegri, C, Vicentini, M, D'Angelo, S, Balottari, P, Romagna, R, Falcini, F, Colamartini, A, Bucchi, L, Balducci, C, Ravegnani, M, Vitali, B, Cordaro, C, Caprara, L, Giuliani, O, Giorgetti, S, Palumbo, M, Vattiato, R, Ravaioli, A, Mancini, S, Tonelli, C, Amadori, M, Cremone, L, Iannelli, A, Senatore, G, Zevola, A, Sechi, O, Budroni, M, Cesaraccio, R, Pirino, D, Carboni, D, Fiori, G, Soddu, M, Mameli, G, Mura, F, Contrino, M, Madeddu, A, Tisano, F, Sciacca, S, Muni, A, Mizzi, M, Russo, M, Sacco, G, Aletta, P, Ziino, A, Tessandori, R, Fanetti, A, Maspero, S, Cecconami, L, Annulli, M, Moroni, E, Gonzalez, M, Zanetti, R, Rosso, S, Patriarca, S, Prandi, R, Sobrato, I, Gilardi, F, Busso, P, Piffer, S, Rizzello, R, Gentilini, M, Cappelletti, M, Rosa, F, Stracci, F, D'Alò, D, Scheibel, M, Costarelli, D, Spano, F, Rossini, S, Santucci, C, Petrinelli, A, Solimene, C, Bianconi, F, Brunori, V, Crosignani, P, Tagliabue, G, Contiero, P, Preto, L, Tittarelli, A, Maghini, A, Codazzi, T, Frassoldi, E, Gada, D, Costa, E, Grazia, L, Zambon, P, Baracco, M, Bovo, E, Cin, A, Fiore, A, Greco, A, Monetti, D, Rosano, A, Stocco, C, Donato, F, Limina, R, Adorni, A, Andreis, P, Zani, G, Piovani, F, Salvi, O, Puleio, M, Vitarelli, S, Candela, G, Pappalardo, G, Scuderi, T, Lottero, B, Ribaudo, M, Ricci, P, Guarda, L, Gatti, L, Bozzeda, A, Dall'Acqua, M, Pironi, V, Sardo, A, Mazzei, A, Sirianni, N, Lavecchia, A, Mancuso, P, Vitale, F, Cusimano, R, Amodio, R, Guttadauro, A, Ravazzolo, B, Bucalo, G, Trapani, C, Sunseri, R, Cascio, M, Brucculeri, M, Adamo, M, Mannino, R, Mistretta, A, Costa, A, Rudisi, G, Gola, G, Corti, M, Prosperini, E, Grandi, L, Sciacchitano, S, Fidelbo, M, Benedetto, G, Vasquez, E, Torrisi, A, Pesce, P, Calabretta, L, Bella, F, Leone, A, Ieni, A, Varvarà, M, Castaing, M, Di Prima, A, Benedetto, A, Paderni, F, Usala, M, Pala, F, Sini, G, Pintori, N, Canu, L, Demurtas, G, Doa, N, Lazzarato, F, Magnani, C, Merletti, F, Sarcerdote, C, Macerata, V, de Leon, M, Domati, F, Rossi, G, Goldoni, C, Rossi, F, De Gaetani, C, Benatti, P, Roncucci, L, Di Gregorio, C, Pedroni, M, Pezzi, A, Maffei, S, Mariani, F, Borsi, E, Cocchioni, M, Pascucci, C, Gennaro, V, Lazzarotto, A, Benfatto, L, Mazzucco, G, Montanaro, F, Traina, A, Carruba, G, Dolcemascolo, C, Staiti, R, Zarcone, M, Bisogno, G, Cuttini, M, De Rosa, M, Haupt, R, Soresina, A, Valsecchi, M, Fagioli, F, Bona, G, Dini, G, Conter, V, Biondi, A, Zecca, M, Fedeli, F, Massimino, M, Nespoli, L, Roncarolo, M, Basso, G, Cesaro, S, Memo, L, Bellettato, M, Tamaro, P, Mascarin, M, Rosolen, A, Izzi, G, Paolucci, P, Borgna Pignatti, C, Vecchi, V, Abate, M, D'Ambrosio, A, Favre, C, Caniglia, M, Pierani, P, Felici, L, Visani, G, Fioritoni, G, Foà, R, Riccardi, R, Frega, G, Clerico, A, Casale, F, Poggi, V, Amendola, G, Filosa, A, Ladogana, S, Presta, G, Tornesello, A, De Mattia, D, Consarino, C, Nobile, F, Sperlì, D, D'Angelo, P, Marino, S, Cosmi, C, Mura, R, Battisti, L, Maso, LD, Mosso, ML, Cappello, TD, Vercellino, PC, Orengo, MA, Celesia, MV, Cercato, MC, Artioli, ME, Vitale, MF, Rosa, MG, Giurdanella, MC, Rollo, PC, Ruggeri, MG, Romagna, Rt, Contrino, ML, Ziino, AC, Fanetti, AC, Annulli, ML, Gonzalez, ME, Gentilini, MA, Rosa, FL, Petrinelli, AM, Grazia, Ld, Cin, AD, Fiore, AR, Limina, RM, Sardo, AS, Lavecchia, AM, Cascio, MA, Brucculeri, MA, Adamo, MS, Sini, GM, de Leon, MP, Goldoni, CA, VALSECCHI, MARIA GRAZIA, BIONDI, ANDREA, Roncarolo, MG, Abate, ME, Mura, RM, Battisti, L., Pisani, P, Buzzoni, C, Crocetti, E, Maso, L, Rondelli, R, Alessi, D, Aricò, M, Bidoli, E, Ferrari, A, Fusco, M, Gatta, G, Guzzinati, S, Jankovic, M, Locatelli, F, Maule, M, Mosso, M, Pastore, G, Pession, A, Rashid, I, Sacerdote, C, Terracini, B, Tognazzo, S, Trama, A, Ferretti, S, Porta, F, Mazzoleni, G, Tschugguel, B, De Valiere, E, Facchinelli, G, Falk, M, Cappello, T, Giacomin, A, Vercellino, P, Andreone, S, Marzola, L, Migliari, E, Carletti, N, Nenci, I, Caldarella, A, Corbinelli, A, Intrieri, T, Manneschi, G, Nemcova, L, Ocello, C, Sacchettini, C, Zappa, M, Paci, E, Serraino, D, Angelin, T, Birri, S, De Dottori, M, De Santis, E, Forgiarini, O, Zucchetto, A, Zanier, L, Vercelli, M, Orengo, M, Casella, C, Marani, E, Puppo, A, Celesia, M, Cogno, R, Levrieri, I, Manenti, S, Garrone, E, Quaglia, A, Pannozzo, F, Busco, S, Ramazzotti, V, Cercato, M, Battisti, W, Sperduti, I, Macci, L, Bugliarello, E, Valerio, O, Bernazza, E, Tamburo, L, Rossi, M, Curatella, S, Tamburrino, S, Fattoruso, S, Bisanti, L, Autelitano, M, Cuccaro, F, Randi, G, Ghilardi, S, Leone, R, Filipazzi, L, Bonini, A, Giubelli, C, Federico, M, Artioli, M, Valla, K, Braghiroli, B, Cirilli, C, Luminari, S, Pirani, M, Ferrari, L, Bellatalla, C, Panico, M, Perrotta, C, Vassante, B, Vitale, M, Michiara, M, Bozzani, F, Sgargi, P, Tumino, R, Rosa, M, Cascone, G, Frasca, G, Giurdanella, M, Martorana, C, Morana, G, Nicita, C, Rollo, P, Ruggeri, M, Sigona, A, Spata, E, Vacirca, S, Mangone, L, Di Felice, E, Pezzarossi, A, Caroli, S, Pellegri, C, Vicentini, M, D'Angelo, S, Balottari, P, Romagna, R, Falcini, F, Colamartini, A, Bucchi, L, Balducci, C, Ravegnani, M, Vitali, B, Cordaro, C, Caprara, L, Giuliani, O, Giorgetti, S, Palumbo, M, Vattiato, R, Ravaioli, A, Mancini, S, Tonelli, C, Amadori, M, Cremone, L, Iannelli, A, Senatore, G, Zevola, A, Sechi, O, Budroni, M, Cesaraccio, R, Pirino, D, Carboni, D, Fiori, G, Soddu, M, Mameli, G, Mura, F, Contrino, M, Madeddu, A, Tisano, F, Sciacca, S, Muni, A, Mizzi, M, Russo, M, Sacco, G, Aletta, P, Ziino, A, Tessandori, R, Fanetti, A, Maspero, S, Cecconami, L, Annulli, M, Moroni, E, Gonzalez, M, Zanetti, R, Rosso, S, Patriarca, S, Prandi, R, Sobrato, I, Gilardi, F, Busso, P, Piffer, S, Rizzello, R, Gentilini, M, Cappelletti, M, Rosa, F, Stracci, F, D'Alò, D, Scheibel, M, Costarelli, D, Spano, F, Rossini, S, Santucci, C, Petrinelli, A, Solimene, C, Bianconi, F, Brunori, V, Crosignani, P, Tagliabue, G, Contiero, P, Preto, L, Tittarelli, A, Maghini, A, Codazzi, T, Frassoldi, E, Gada, D, Costa, E, Grazia, L, Zambon, P, Baracco, M, Bovo, E, Cin, A, Fiore, A, Greco, A, Monetti, D, Rosano, A, Stocco, C, Donato, F, Limina, R, Adorni, A, Andreis, P, Zani, G, Piovani, F, Salvi, O, Puleio, M, Vitarelli, S, Candela, G, Pappalardo, G, Scuderi, T, Lottero, B, Ribaudo, M, Ricci, P, Guarda, L, Gatti, L, Bozzeda, A, Dall'Acqua, M, Pironi, V, Sardo, A, Mazzei, A, Sirianni, N, Lavecchia, A, Mancuso, P, Vitale, F, Cusimano, R, Amodio, R, Guttadauro, A, Ravazzolo, B, Bucalo, G, Trapani, C, Sunseri, R, Cascio, M, Brucculeri, M, Adamo, M, Mannino, R, Mistretta, A, Costa, A, Rudisi, G, Gola, G, Corti, M, Prosperini, E, Grandi, L, Sciacchitano, S, Fidelbo, M, Benedetto, G, Vasquez, E, Torrisi, A, Pesce, P, Calabretta, L, Bella, F, Leone, A, Ieni, A, Varvarà, M, Castaing, M, Di Prima, A, Benedetto, A, Paderni, F, Usala, M, Pala, F, Sini, G, Pintori, N, Canu, L, Demurtas, G, Doa, N, Lazzarato, F, Magnani, C, Merletti, F, Sarcerdote, C, Macerata, V, de Leon, M, Domati, F, Rossi, G, Goldoni, C, Rossi, F, De Gaetani, C, Benatti, P, Roncucci, L, Di Gregorio, C, Pedroni, M, Pezzi, A, Maffei, S, Mariani, F, Borsi, E, Cocchioni, M, Pascucci, C, Gennaro, V, Lazzarotto, A, Benfatto, L, Mazzucco, G, Montanaro, F, Traina, A, Carruba, G, Dolcemascolo, C, Staiti, R, Zarcone, M, Bisogno, G, Cuttini, M, De Rosa, M, Haupt, R, Soresina, A, Valsecchi, M, Fagioli, F, Bona, G, Dini, G, Conter, V, Biondi, A, Zecca, M, Fedeli, F, Massimino, M, Nespoli, L, Roncarolo, M, Basso, G, Cesaro, S, Memo, L, Bellettato, M, Tamaro, P, Mascarin, M, Rosolen, A, Izzi, G, Paolucci, P, Borgna Pignatti, C, Vecchi, V, Abate, M, D'Ambrosio, A, Favre, C, Caniglia, M, Pierani, P, Felici, L, Visani, G, Fioritoni, G, Foà, R, Riccardi, R, Frega, G, Clerico, A, Casale, F, Poggi, V, Amendola, G, Filosa, A, Ladogana, S, Presta, G, Tornesello, A, De Mattia, D, Consarino, C, Nobile, F, Sperlì, D, D'Angelo, P, Marino, S, Cosmi, C, Mura, R, Battisti, L, Maso, LD, Mosso, ML, Cappello, TD, Vercellino, PC, Orengo, MA, Celesia, MV, Cercato, MC, Artioli, ME, Vitale, MF, Rosa, MG, Giurdanella, MC, Rollo, PC, Ruggeri, MG, Romagna, Rt, Contrino, ML, Ziino, AC, Fanetti, AC, Annulli, ML, Gonzalez, ME, Gentilini, MA, Rosa, FL, Petrinelli, AM, Grazia, Ld, Cin, AD, Fiore, AR, Limina, RM, Sardo, AS, Lavecchia, AM, Cascio, MA, Brucculeri, MA, Adamo, MS, Sini, GM, de Leon, MP, Goldoni, CA, VALSECCHI, MARIA GRAZIA, BIONDI, ANDREA, Roncarolo, MG, Abate, ME, Mura, RM, and Battisti, L.

Abstract

This study describes up-to-date cancer incidence and survival in Italian paediatric and adolescent patients, based on data collected by the network of Italian cancer registries (AIRTUM). It updates the monograph published on the same topic in 2008. The main objective of this monograph is to present the statistics according to standard rigorous epidemiological methods and disseminate them to a wide range of readers, including the lay public. Given the deep impact of the 2008 monograph on the general public, in this update we complement descriptive statistics with additional data and commentaries on issues of importance for public health, in order to provide unambiguous criteria on how to interpret the statistics. The study is the result of the collaboration between AIRTUM and AIEOP (Italian Association of Paediatric Haematology and Oncology) with contributions from interested parties, including representatives of parent associations. The monograph is divided into three parts. The first part presents incidence rates, survival probabilities, and time trends, by sex, age, geographical area, and cancer site or type, by means of tables and graphs as in the previous monograph, to facilitate direct comparisons. Four articles summarize and comment the results. The second part uses data from AIRTUM and AIEOP to outline patient management and health care issues; it includes estimates of the number of new cases in the next decade and of young adults living after a paediatric cancer diagnosis. Health organizational aspects of treatment services for paediatric patients, based on the AIEOP database, are also discussed, along with long-term complications in cured patients. The third section describes the changes in mortality trends due to improving therapies and healthcare services, and discusses risk factors and prevention of childhood cancer, late adverse events in cured patients, and other related issues.

Published
2013

42. Italian cancer figures, report 2012: Cancer in children and adolescents

Author

Pisani, P, Buzzoni, C, Crocetti, E, Maso, Ld, Rondelli, R, Alessi, D, Aricò, M, Bidoli, E, Ferrari, A, Fusco, M, Gatta, G, Guzzinati, S, Jankovic, M, Locatelli, F, Maule, M, Mosso, Ml, Pastore, G, Pession, A, Rashid, I, Sacerdote, C, Terracini, B, Tognazzo, S, Trama, A, Ferretti, S, Porta, F, Mazzoleni, G, Tschugguel, B, De Valiere, E, Facchinelli, G, Falk, M, Cappello, Td, Giacomin, A, Vercellino, Pc, Andreone, S, Marzola, L, Migliari, E, Carletti, N, Nenci, I, Caldarella, A, Corbinelli, A, Intrieri, T, Manneschi, G, Nemcova, L, Ocello, C, Sacchettini, C, Zappa, M, Paci, E, Serraino, D, Angelin, T, Birri, S, De Dottori, M, De Santis, E, Forgiarini, O, Zucchetto, A, Zanier, L, Vercelli, M, Orengo, Ma, Casella, C, Marani, E, Puppo, A, Celesia, Mv, Cogno, R, Levrieri, I, Manenti, S, Garrone, E, Quaglia, A, Pannozzo, F, Busco, S, Ramazzotti, V, Cercato, Mc, Battisti, W, Sperduti, I, Macci, L, Bugliarello, E, Valerio, O, Bernazza, E, Tamburo, L, Rossi, M, Curatella, S, Tamburrino, S, Fattoruso, S, Bisanti, L, Autelitano, M, Cuccaro, F, Randi, G, Ghilardi, S, Leone, R, Filipazzi, L, Bonini, A, Giubelli, C, Federico, M, Artioli, Me, Valla, K, Braghiroli, B, Cirilli, C, Luminari, S, Pirani, M, Ferrari, L, Bellatalla, C, Panico, M, Perrotta, C, Vassante, B, Vitale, Mf, Michiara, M, Bozzani, F, Sgargi, P, Tumino, R, Rosa, Mg, Cascone, G, Frasca, G, Giurdanella, Mc, Martorana, C, Morana, G, Nicita, C, Rollo, Pc, Ruggeri, Mg, Sigona, A, Spata, E, Vacirca, S, Mangone, L, Di Felice, E, Pezzarossi, A, Caroli, S, Pellegri, C, Vicentini, M, D'Angelo, S, Balottari, P, Romagna, Rt, Falcini, F, Colamartini, A, Bucchi, L, Balducci, C, Ravegnani, M, Vitali, B, Cordaro, C, Caprara, L, Giuliani, O, Giorgetti, S, Palumbo, M, Vattiato, R, Ravaioli, A, Mancini, S, Tonelli, C, Amadori, M, Cremone, L, Iannelli, A, Senatore, G, Zevola, A, Sechi, O, Budroni, M, Cesaraccio, R, Pirino, D, Carboni, D, Fiori, G, Soddu, M, Mameli, G, Mura, F, Contrino, Ml, Madeddu, A, Tisano, F, Sciacca, S, Muni, A, Mizzi, M, Russo, M, Sacco, G, Aletta, P, Ziino, Ac, Tessandori, R, Fanetti, Ac, Maspero, S, Cecconami, L, Annulli, Ml, Moroni, E, Gonzalez, Me, Zanetti, R, Rosso, S, Patriarca, S, Prandi, R, Sobrato, I, Gilardi, F, Busso, P, Piffer, S, Rizzello, R, Gentilini, Ma, Cappelletti, M, Rosa, Fl, Stracci, F, D'Alò, D, Scheibel, M, Costarelli, D, Spano, F, Rossini, S, Santucci, C, Petrinelli, Am, Solimene, C, Bianconi, F, Brunori, V, Crosignani, P, Tagliabue, G, Contiero, P, Preto, L, Tittarelli, A, Maghini, A, Codazzi, T, Frassoldi, E, Gada, D, Costa, E, Grazia, Ld, Zambon, P, Baracco, M, Bovo, E, Cin, Ad, Fiore, Ar, Greco, A, Monetti, D, Rosano, A, Stocco, C, Donato, F, Limina, Rm, Adorni, A, Andreis, P, Zani, G, Piovani, F, Salvi, O, Puleio, M, Vitarelli, S, Candela, G, Pappalardo, G, Scuderi, T, Lottero, B, Ribaudo, M, Ricci, P, Guarda, L, Gatti, L, Bozzeda, A, Dall'Acqua, M, Pironi, V, Sardo, As, Mazzei, A, Sirianni, N, Lavecchia, Am, Mancuso, P, Vitale, F, Cusimano, R, Amodio, R, Guttadauro, A, Ravazzolo, B, Bucalo, G, Trapani, C, Sunseri, R, Cascio, Ma, Brucculeri, Ma, Adamo, Ms, Mannino, R, Mistretta, A, Costa, A, Rudisi, G, Gola, G, Corti, M, Prosperini, E, Grandi, L, Sciacchitano, S, Fidelbo, M, Benedetto, G, Vasquez, E, Torrisi, A, Pesce, P, Calabretta, L, Bella, F, Leone, A, Ieni, A, Varvarà, M, Castaing, M, Di Prima, A, Benedetto, A, Paderni, F, Usala, M, Pala, F, Sini, Gm, Pintori, N, Canu, L, Demurtas, G, Doa, N, Lazzarato, F, Magnani, C, Merletti, F, Sarcerdote, C, Macerata, V, de Leon MP, Domati, F, Rossi, G, Goldoni, Ca, Rossi, F, De Gaetani, C, Benatti, P, Roncucci, L, Di Gregorio, C, Pedroni, M, Pezzi, A, Maffei, S, Mariani, F, Borsi, E, Cocchioni, M, Pascucci, C, Gennaro, V, Lazzarotto, A, Benfatto, L, Mazzucco, G, Montanaro, F, Traina, A, Carruba, G, Dolcemascolo, C, Staiti, R, Zarcone, M, Bisogno, G, Cuttini, M, De Rosa, M, Haupt, R, Soresina, A, Valsecchi, Mg, Fagioli, F, Bona, G, Dini, G, Conter, V, Biondi, A, Zecca, M, Fedeli, F, Massimino, M, Nespoli, L, Roncarolo, Mg, Basso, G, Cesaro, S, Memo, L, Bellettato, M, Tamaro, Paolo, Mascarin, M, Rosolen, A, Izzi, G, Paolucci, P, Borgna Pignatti, C, Vecchi, V, Abate, Me, D'Ambrosio, A, Favre, C, Caniglia, M, Pierani, P, Felici, L, Visani, G, Fioritoni, G, Foà, R, Riccardi, R, Frega, G, Clerico, A, Casale, F, Poggi, V, Amendola, G, Filosa, A, Ladogana, S, Presta, G, Tornesello, A, De Mattia, D, Consarino, C, Nobile, F, Sperlì, D, D'Angelo, P, Marino, S, Cosmi, C, Mura, Rm, Battisti, L., Pisani, P, Buzzoni, C, Crocetti, E, Maso, Ld, Rondelli, R, Alessi, D, Aricò, M, Bidoli, E, Ferrari, A, Fusco, M, Gatta, G, Guzzinati, S, Jankovic, M, Locatelli, F, Maule, M, Mosso, Ml, Pastore, G, Pession, A, Rashid, I, Sacerdote, C, Terracini, B, Tognazzo, S, Trama, A, Ferretti, S, Porta, F, Mazzoleni, G, Tschugguel, B, De Valiere, E, Facchinelli, G, Falk, M, Cappello, Td, Giacomin, A, Vercellino, Pc, Andreone, S, Marzola, L, Migliari, E, Carletti, N, Nenci, I, Caldarella, A, Corbinelli, A, Intrieri, T, Manneschi, G, Nemcova, L, Ocello, C, Sacchettini, C, Zappa, M, Paci, E, Serraino, D, Angelin, T, Birri, S, De Dottori, M, De Santis, E, Forgiarini, O, Zucchetto, A, Zanier, L, Vercelli, M, Orengo, Ma, Casella, C, Marani, E, Puppo, A, Celesia, Mv, Cogno, R, Levrieri, I, Manenti, S, Garrone, E, Quaglia, A, Pannozzo, F, Busco, S, Ramazzotti, V, Cercato, Mc, Battisti, W, Sperduti, I, Macci, L, Bugliarello, E, Valerio, O, Bernazza, E, Tamburo, L, Rossi, M, Curatella, S, Tamburrino, S, Fattoruso, S, Bisanti, L, Autelitano, M, Cuccaro, F, Randi, G, Ghilardi, S, Leone, R, Filipazzi, L, Bonini, A, Giubelli, C, Federico, M, Artioli, Me, Valla, K, Braghiroli, B, Cirilli, C, Luminari, S, Pirani, M, Ferrari, L, Bellatalla, C, Panico, M, Perrotta, C, Vassante, B, Vitale, Mf, Michiara, M, Bozzani, F, Sgargi, P, Tumino, R, Rosa, Mg, Cascone, G, Frasca, G, Giurdanella, Mc, Martorana, C, Morana, G, Nicita, C, Rollo, Pc, Ruggeri, Mg, Sigona, A, Spata, E, Vacirca, S, Mangone, L, Di Felice, E, Pezzarossi, A, Caroli, S, Pellegri, C, Vicentini, M, D'Angelo, S, Balottari, P, Romagna, Rt, Falcini, F, Colamartini, A, Bucchi, L, Balducci, C, Ravegnani, M, Vitali, B, Cordaro, C, Caprara, L, Giuliani, O, Giorgetti, S, Palumbo, M, Vattiato, R, Ravaioli, A, Mancini, S, Tonelli, C, Amadori, M, Cremone, L, Iannelli, A, Senatore, G, Zevola, A, Sechi, O, Budroni, M, Cesaraccio, R, Pirino, D, Carboni, D, Fiori, G, Soddu, M, Mameli, G, Mura, F, Contrino, Ml, Madeddu, A, Tisano, F, Sciacca, S, Muni, A, Mizzi, M, Russo, M, Sacco, G, Aletta, P, Ziino, Ac, Tessandori, R, Fanetti, Ac, Maspero, S, Cecconami, L, Annulli, Ml, Moroni, E, Gonzalez, Me, Zanetti, R, Rosso, S, Patriarca, S, Prandi, R, Sobrato, I, Gilardi, F, Busso, P, Piffer, S, Rizzello, R, Gentilini, Ma, Cappelletti, M, Rosa, Fl, Stracci, F, D'Alò, D, Scheibel, M, Costarelli, D, Spano, F, Rossini, S, Santucci, C, Petrinelli, Am, Solimene, C, Bianconi, F, Brunori, V, Crosignani, P, Tagliabue, G, Contiero, P, Preto, L, Tittarelli, A, Maghini, A, Codazzi, T, Frassoldi, E, Gada, D, Costa, E, Grazia, Ld, Zambon, P, Baracco, M, Bovo, E, Cin, Ad, Fiore, Ar, Greco, A, Monetti, D, Rosano, A, Stocco, C, Donato, F, Limina, Rm, Adorni, A, Andreis, P, Zani, G, Piovani, F, Salvi, O, Puleio, M, Vitarelli, S, Candela, G, Pappalardo, G, Scuderi, T, Lottero, B, Ribaudo, M, Ricci, P, Guarda, L, Gatti, L, Bozzeda, A, Dall'Acqua, M, Pironi, V, Sardo, A, Mazzei, A, Sirianni, N, Lavecchia, Am, Mancuso, P, Vitale, F, Cusimano, R, Amodio, R, Guttadauro, A, Ravazzolo, B, Bucalo, G, Trapani, C, Sunseri, R, Cascio, Ma, Brucculeri, Ma, Adamo, M, Mannino, R, Mistretta, A, Costa, A, Rudisi, G, Gola, G, Corti, M, Prosperini, E, Grandi, L, Sciacchitano, S, Fidelbo, M, Benedetto, G, Vasquez, E, Torrisi, A, Pesce, P, Calabretta, L, Bella, F, Leone, A, Ieni, A, Varvarà, M, Castaing, M, Di Prima, A, Benedetto, A, Paderni, F, Usala, M, Pala, F, Sini, Gm, Pintori, N, Canu, L, Demurtas, G, Doa, N, Lazzarato, F, Magnani, C, Merletti, F, Sarcerdote, C, Macerata, V, de Leon, Mp, Domati, F, Rossi, G, Goldoni, Ca, Rossi, F, De Gaetani, C, Benatti, P, Roncucci, L, Di Gregorio, C, Pedroni, M, Pezzi, A, Maffei, S, Mariani, F, Borsi, E, Cocchioni, M, Pascucci, C, Gennaro, V, Lazzarotto, A, Benfatto, L, Mazzucco, G, Montanaro, F, Traina, A, Carruba, G, Dolcemascolo, C, Staiti, R, Zarcone, M, Bisogno, G, Cuttini, M, De Rosa, M, Haupt, R, Soresina, A, Valsecchi, Mg, Fagioli, F, Bona, G, Dini, G, Conter, V, Biondi, A, Zecca, M, Fedeli, F, Massimino, M, Nespoli, L, Roncarolo, Mg, Basso, G, Cesaro, S, Memo, L, Bellettato, M, Tamaro, Paolo, Mascarin, M, Rosolen, A, Izzi, G, Paolucci, P, Borgna Pignatti, C, Vecchi, V, Abate, Me, D'Ambrosio, A, Favre, C, Caniglia, M, Pierani, P, Felici, L, Visani, G, Fioritoni, G, Foà, R, Riccardi, R, Frega, G, Clerico, A, Casale, F, Poggi, V, Amendola, G, Filosa, A, Ladogana, S, Presta, G, Tornesello, A, De Mattia, D, Consarino, C, Nobile, F, Sperlì, D, D'Angelo, P, Marino, S, Cosmi, C, Mura, Rm, Battisti, L., Maso, L, Mosso, M, Cappello, T, Vercellino, P, Orengo, M, Celesia, M, Cercato, M, Artioli, M, Vitale, M, Rosa, M, Giurdanella, M, Rollo, P, Ruggeri, M, Romagna, R, Contrino, M, Ziino, A, Fanetti, A, Annulli, M, Gonzalez, M, Gentilini, M, Rosa, F, Petrinelli, A, Grazia, L, Cin, A, Fiore, A, Limina, R, Lavecchia, A, Cascio, M, Brucculeri, M, Sini, G, de Leon, M, Goldoni, C, Valsecchi, M, Roncarolo, M, Tamaro, P, Abate, M, Mura, R, Battisti, L, AIRTUM Working Group[.., Enrica Borsi, ], CCM, and AIEOP Working Group

Subjects
Male, Parents, cancer incidence, Adolescent, Epidemiology, Aftercare, cancer in adolescents, Young Adult, children, Neoplasms, cancer in children, Italian population, cancer, Cluster Analysis, Humans, Registries, Survivors, Age of Onset, Mortality, Child, cancer survival, Incidence, Environmental and Occupational Health, Infant, Newborn, Disease Management, Infant, pediatric, Survival Rate, Italy, Child, Preschool, Public Health, Environmental and Occupational Health, Female, Public Health, Morbidity, Forecasting
Abstract

OBJECTIVES: This study describes up-to-date cancer incidence and survival in Italian paediatric and adolescent patients, based on data collected by the network of Italian cancer registries (AIRTUM). It updates the monograph published on the same topic in 2008. The main objective of this monograph is to present the statistics according to standard rigorous epidemiological methods and disseminate them to a wide range of readers, including the lay public. Given the deep impact of the 2008 monograph on the general public, in this update we complement descriptive statistics with additional data and commentaries on issues of importance for public health, in order to provide unambiguous criteria on how to interpret the statistics. The study is the result of the collaboration between AIRTUM and AIEOP (Italian Association of Paediatric Haematology and Oncology) with contributions from interested parties, including representatives of parent associations. The monograph is divided into three parts. The first part presents incidence rates, survival probabilities, and time trends, by sex, age, geographical area, and cancer site or type, by means of tables and graphs as in the previous monograph, to facilitate direct comparisons. Four articles summarize and comment the results. The second part uses data from AIRTUM and AIEOP to outline patient management and health care issues; it includes estimates of the number of new cases in the next decade and of young adults living after a paediatric cancer diagnosis. Health organizational aspects of treatment services for paediatric patients, based on the AIEOP database, are also discussed, along with long-term complications in cured patients. The third section describes the changes in mortality trends due to improving therapies and healthcare services, and discusses risk factors and prevention of childhood cancer, late adverse events in cured patients, and other related issues. MATERIAL AND METHODS: Data herein presented were provided by AIRTUM population-based cancer registries, covering 47%of the Italian population below age 20 years, in the period 2003-2008. Quality of cancer registration in Italy is elevated, with high proportions of microscopically verified diagnoses (91%in the 0-14 years age group and 96% between 15 and 19 years of age) and a very small proportion of cases collected through death certificate only (0.1%).The proportion of cases in diagnostic groups XI (other malignant epithelial neoplasms) and XII (other and unspecified neoplasms) of the International Classification for Childhood Cancer (ICCC), based on the third revision of the International Classification of Diseases for Oncology (ICD-O-3), were 7.0% in the 0-14 years age group and 26.0%in the 15-19 years age group.The ratio between mortality and incidence was 17.7% in both children and adolescents. Detailed results are presented in 24 fact sheets for the 12 major ICCC-3 diagnostic groups and 10 sub-groups of special interest; the series is completed by a sheet on all malignant tumours and one on all tumours including non-malignant neoplasms of the central nervous system. All sheets include results for three age groups (0-14, 15-19, and 0-19 years) and are followed by two commentaries on incidence in the recent period, one on trends and the other on survival. Incidence rates were age-standardized on the European population and presented per million children. Incidence rates are also presented by age group, sex, and geographical area. Incidence trends were evaluated for two periods, 1988-2008 and 1998-2008, using estimated annual percent changes, and survival estimates were calculated by age and period. Indicators and corresponding 95% confidence intervals are shown in forms of graphics and tables at the end of the monograph and online at http://www.registri-tumori.it. Geographical analyses were conducted rearranging cancer registries into four macroareas (North-West, North-East, Centre, and South and Islands). Age groups were the same used in descriptive studies on children worldwide (0, 1-4, 5-9, 10- 14 years for paediatric tumours and 15-19 years for adolescents). Incidence trend analyses included cancer registries with three or more years of registration in the 5-year period, using Poisson regression models. Observed survival was computed according to the Kaplan-Meier method. The estimate of expected cases in the next decade was based on observed incidence rates in the most recent period, extended to the Italian estimated population of children and adolescents in the periods 2011-2015 and 2016-2020. The AIEOP database (Modello 1.01) allowed us to compare the number of patients treated and followed-up in specialized centres with expected cases based on AIRTUM estimates. The AIEOP database also provided information regarding health care migration throughout Italian regions and the number of foreign (immigrated) children treated in Italian AIEOP centres. RESULTS: In the period 2003-2008, 31 cancer registries reported 4,473 incident malignant neoplasms, 2,855 in children and 1,618 in adolescents. Cancer incidence rates were 164 cases per million in children aged 14 years or below and 269 cases per million in patients aged 15-19 years. Limited geographical variations emerged. In children (0-14 years) a significant increase in malignant cancer incidence was observed until 1997 (APC: +3.2%), followed by a plateau (APC: -1.1%not statistically significant).Until the late Nineties, a statistically significant increase was also observed in the incidence of all leukaemias in males (APC: +5.7%), lymphoid leukaemias (APC: +5.6%), representing 80% of all leukaemias, Hodgkin and non- Hodgkin lymphomas (APC: +6.3%). A significant decrease emerged for lymphoid leukaemia starting in 1995 (APC: -1.9%), while no substantial change in cancer incidence rates was observed in the last decade of observation for all malignant neoplasms and lymphomas. In addition, no variation emerged for malignant (according to the most recent classification) central nervous system (CNS) neoplasms, while an annual increase of 1.8% (significant) was observed in the period 1988-2008, when non-malignant tumours were included. Increases in cancer incidence were observed throughout the study period for neuroblastoma (APC: +1.9%) and epithelial tumours or melanoma (APC: +4.1%). In the period 1998-2008, in addition to lymphoid leukaemias, a significant decrease was observed for all malignant neoplasms, lymphomas in girls, CNS tumours (males and females), and renal tumours in girls, while no increases were observed in this age group. In adolescents (15-19 years) between 1988 and 2008, a significant increase in incidence rates was observed (APC: +2.0%) for all malignant neoplasms, all lymphomas (APC: +2.9%; in particular Hodgkin lymphoma, APC: +3.6%), thyroid cancer (APC: +6.1%), and melanoma (APC: +8.1%). Conversely, lymphoid leukaemia is the only neoplasm showing a long-term decrease in adolescents. Recent trends (1998-2008) confirm the long-term increases only for all malignant neoplasms in girls and thyroid cancer (APC: +7.9%, boys and girls), while a decrease in bone tumour incidence emerged in girls, albeit based only on 46 cases. Cancer mortality in children showed a persistent decrease for all neoplasms and even for more frequent cancer sites or types, and mortality rates for cancer were three-fold higher in the early Seventies than in 2008. In addition, five-year survival after cancer diagnosis increased in the last three decades and was still increasing in the period 2003- 2008, reaching 82% in children and 86% in adolescents. In the period 2008-2010, 4,488 children (0-14 years) were treated in one of the AIEOP clinical centres and we estimate, based on the above-presented incidence rates, that they represented 92% of all cancer cases in Italy. However, in adolescents, the proportion of patients treated in AIEOP centres was only 25%. A migration of patients living in the South of Italy to Central and Northern Italy emerged from AIEOP information. The expected number of cancer cases in children aged between 0 and 14 years of age is approximately 7,000 in the period 2016- 2020, while the corresponding figure for adolescents between 15 and 19 years of age is 4,000, with no relevant variation in comparison with the previous five-year period. COMMENTS: The present findings update descriptive cancer epidemiology in children and adolescents in Italy based on data provided by an extensive network of general and specialized population-based cancer registries. Data obtained from cancer registries are supplemented by additional information collected by specialized clinical AIEOP centres and mortality reports collected by the National Institute of Statistics (ISTAT). Incidence rates reported in Italy were slightly higher in comparison to other developed Countries, but relatively consistent between different Italian areas. Our results also showed that the significant increase in cancer incidence observed until the end of Nineties has halted, with the exception solely of thyroid cancer in adolescents. Efficacy of therapeutic protocols has improved constantly since the Seventies, and recent findings confirm this trend in all age groups and, in particular, for rarer tumours and cancer types that have very poor prognosis. Findings derived from cross-analysis with AIEOP data suggest that it is possible to further improve the efficiency of our healthcare system, in particular for adolescents; migration can be reduced with a more rational use of hospitals throughout Italy.

45. Italian cancer figures: North and South are getting closer,I tumori in Italia: Nord e Sud si avvicinano

Author

Ferretti, S., Crocetti, E., Buzzoni, C., Bisanti, L., Budroni, M., Candela, G., Crosignani, P., Lisi, V., Donato, A., Donato, F., Falcini, F., Federico, M., Fusco, M., Gennaro, V., Giacomin, A., La Rosa, F., Madeddu, A., Contrino, M. P., Lucia Mangone, Mazzoleni, G., Pannozzo, F., Pascucci, C., Cocchioni, M., Piffer, S., Pisani, P., Leon, M. P., Ricci, P., Serraino, D., Sutera, A., Tessandori, R., Traina, A., Tumino, R., Usala, M., Vercelli, M., Vitarelli, S., Zambon, P., and Zanetti, R.

46. Sentieri-epidemiological study of residents in national priority contaminated sites: Mortality, cancer incidence and hospital discharges,Sentieri-studio epidemiologico nazionale dei territori e degli insediamenti esposti a rischio da inquinamento: Mortalità, incidenza oncologica e ricoveri ospedalieri

Author

Ancona, C., Ascoli, V., Bastone, A., Beccaloni, E., Benedetti, M., Bianchi, F., Biggeri, A., Binazzi, A., Bruno, C., Cadum, E., Caranci, N., Carboni, C., Carere, M., Catelan, D., Cernigliaro, A., Comba, P., Conti, S., Corfiati, M., Demaria, M., Santis, M. D., Falleni, F., Fazzo, L., Forastiere, F., Goldoni, C. A., Grisotto, L., Iavarone, I., Leonardi, M., Manno, V., Marcello, I., Marinaccio, A., Marsili, G., Martuzzi, M., Minelli, G., Minichilli, F., Mitis, F., Musmeci, L., Pasetto, R., Piccardi, A., Pirastu, R., Santoro, M., Scaini, F., Soggiu, M. E., Zona, A., Autelitano, M., Benfatto, L., Bonelli, L., Bianconi, F., Bidoli, E., Buzzoni, C., Candela, G., Cocchioni, M., Coviello, E., Cremone, L., Crocetti, E., Tos, A. P. D., Falcini, F., Federico, M., Ferretti, S., Fusco, M., Giacomin, A., Gola, G., Guzzinati, S., Rosa, F. L., Lillini, R., Madeddu, A., Magoni, M., Mangone, L., Maspero, S., Maule, M., Mazzoleni, G., Merletti, F., Michiara, M., Minerba, S., Nicita, C., Pannozzo, F., Piffer, S., Ricci, P., Carlotta Sacerdote, Sciacca, S., Sechi, O., Serraino, D., Stracci, F., Sardo, A. S., Tagliabue, G., Tisano, F., Usala, M., Vercelli, M., Vitale, F., Vitarelli, S., and Zambon, P.

47. [Incidence of stomach cancer is decreasing faster in the Centre-North of Italy]

Author

Castaing, M, Bella, F, Buzzoni, C, Bisanti, L, Sechi, O, Candela, G, Crosignani, P, De Lisi, V, Donato, A, Mangoni, M, Falcini, F, Federico, Massimo, Fusco, M, Gennaro, V, Giacomin, A, La Rosa, F, Madeddu, A, Contrino, Ml, Mangone, L, Mazzoleni, G, Pannozzo, F, Zanetti, R, Cocchioni, M, Piffer, S, Pisani, P, PONZ DE LEON, Maurizio, Ricci, P, Serraino, D, Sutera, A, Tessandori, R, Traina, A, Tumino, R, Usala, M, Vercelli, M, Vitarelli, S, Zambon, P, Crocetti, E, Ferretti, S, Gola, G, and Sciacca, S.

Subjects
Male, Italy, Stomach Neoplasms, Incidence, Humans, Female, stomach, CANCER, Morbidity

49. Cold exposure increases exercise-induced oxidative stress

Author

Martarelli, D., Cocchioni, M., Scuri, S., Antonio Spataro, and Pompei, P.

Subjects
Adult, Cold Temperature, Male, Oxidative Stress, Humans, Reactive Oxygen Species, Antioxidants, Bicycling
Abstract

We determined the combined effects of cold and exercise on oxidative stress during submaximal exercise.Sixteen amateur male cyclists pedaled at a constant speed corresponding to 85% of maximal HR as determined in normal conditions. Eight athletes pedaled indoors at 23 °C while 8 athletes pedaled outdoors at a temperature of 4-6 °C. We then evaluated the levels of reactive oxygen metabolites and plasma levels of antioxidants after exercise.Performing a physical task in cold conditions increased the free radical production, as demonstrated by the augmented levels of reactive oxygen metabolites and the concomitant decrease of plasma levels of antioxidants in outdoors cyclists as compared to indoors cyclists. The overall ANOVA and the post-hoc comparisons revealed a significant exercise and temperature effect. The mean level of reactive oxygen metabolites in athletes who exercised indoors was significantly lower than that of the outdoor athletes. Moreover, the outdoors group presented plasma levels of antioxidants significantly lower than those of the indoors group.Since several sports are performed outdoors during the winter season, the increased risk of oxidative stress in cold conditions must be considered in these disciplines. Cyclists, football and rugby players, and runners are all affected by the elevation in oxygen radicals induced by cold and should take appropriate precautions, such as specific antioxidant integration.

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