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6. Critical assessment of variant prioritization methods for rare disease diagnosis within the rare genomes project

Author

Stenton, Sarah L., O’Leary, Melanie C., Lemire, Gabrielle, VanNoy, Grace E., DiTroia, Stephanie, Ganesh, Vijay S., Groopman, Emily, O’Heir, Emily, Mangilog, Brian, Osei-Owusu, Ikeoluwa, Pais, Lynn S., Serrano, Jillian, Singer-Berk, Moriel, Weisburd, Ben, Wilson, Michael W., Austin-Tse, Christina, Abdelhakim, Marwa, Althagafi, Azza, Babbi, Giulia, Bellazzi, Riccardo, Bovo, Samuele, Carta, Maria Giulia, Casadio, Rita, Coenen, Pieter-Jan, De Paoli, Federica, Floris, Matteo, Gajapathy, Manavalan, Hoehndorf, Robert, Jacobsen, Julius O. B., Joseph, Thomas, Kamandula, Akash, Katsonis, Panagiotis, Kint, Cyrielle, Lichtarge, Olivier, Limongelli, Ivan, Lu, Yulan, Magni, Paolo, Mamidi, Tarun Karthik Kumar, Martelli, Pier Luigi, Mulargia, Marta, Nicora, Giovanna, Nykamp, Keith, Pejaver, Vikas, Peng, Yisu, Pham, Thi Hong Cam, Podda, Maurizio S., Rao, Aditya, Rizzo, Ettore, Saipradeep, Vangala G., Savojardo, Castrense, Schols, Peter, Shen, Yang, Sivadasan, Naveen, Smedley, Damian, Soru, Dorian, Srinivasan, Rajgopal, Sun, Yuanfei, Sunderam, Uma, Tan, Wuwei, Tiwari, Naina, Wang, Xiao, Wang, Yaqiong, Williams, Amanda, Worthey, Elizabeth A., Yin, Rujie, You, Yuning, Zeiberg, Daniel, Zucca, Susanna, Bakolitsa, Constantina, Brenner, Steven E., Fullerton, Stephanie M., Radivojac, Predrag, Rehm, Heidi L., and O’Donnell-Luria, Anne

Published
2024
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10. Mapping Contextual Factors Influencing Physical Activity Behavior of People with a Physical Demanding Job

Author

Beckmann, Julia, Coenen, Pieter, Speklé, Erwin, Kraal, Jos J., Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Melles, Marijke, editor, Albayrak, Armaĝan, editor, and Goossens, Richard H.M., editor

Published
2024
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13. (Cost-)effectiveness of a personalized multidisciplinary eHealth intervention for knee arthroplasty patients to enhance return to activities of daily life, work and sports – rationale and protocol of the multicentre ACTIVE randomized controlled trial

Author

Straat, A. Carlien, Maarleveld, Jantine M., Smit, Denise J. M., Visch, Lara, Hulsegge, Gerben, Huirne, Judith A. F., van Dongen, J. M., van Geenen, Rutger C., Kerkhoffs, Gino M. M. J., Anema, Johannes R., Coenen, Pieter, and Kuijer, P. Paul F. M.

Published
2023
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17. Associations of occupational and leisure-time physical activity with all-cause mortality: an individual participant data meta-analysis.

Author

Coenen, Pieter, Huysmans, Maaike A., Holtermann, Andreas, Troiano, Richard P., Mork, Paul Jarle, Krokstad, Steinar, Clays, Els, Cillekens, Bart, De Bacquer, Dirk, Aadahl, Mette, Kårhus, Line Lund, Sjøl, Anette, Andersen, Lars Bo, Kauhanen, Jussi, Voutilainen, Ari, Pulsford, Richard M., Stamatakis, Emmanuel, Goldbourt, Uri, Peters, Annette, and Thorand, Barbara

Subjects
LONG-distance running, PERSONAL identification numbers, MEDICAL care use, HEART disease related mortality, SPORTS participation, HEALTH behavior, OLDER men, HANDBALL players
Published
2024
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18. Device-measured stationary behaviour and cardiovascular and orthostatic circulatory disease incidence.

Author

Ahmadi, Matthew N, Coenen, Pieter, Straker, Leon, and Stamatakis, Emmanuel

Subjects
*VARICOSE veins, *VENOUS insufficiency, *CORONARY disease, *SEDENTARY behavior, *ORTHOSTATIC hypotension
Abstract

Background Previous studies have indicated that standing may be beneficially associated with surrogate metabolic markers, whereas more time spent sitting has an adverse association. Studies assessing the dose-response associations of standing, sitting and composite stationary behaviour time with cardiovascular disease (CVD) and orthostatic circulatory disease are scarce and show an unclear picture. Objective To examine associations of daily sitting, standing and stationary time with CVD and orthostatic circulatory disease incidence Methods We used accelerometer data from 83 013 adults (mean age ± standard deviation = 61.3 ± 7.8; female = 55.6%) from the UK Biobank to assess daily time spent sitting and standing. Major CVD was defined as coronary heart disease, heart failure and stroke. Orthostatic circulatory disease was defined as orthostatic hypotension, varicose vein, chronic venous insufficiency and venous ulcers. To estimate the dose-response hazard ratios (HR) we used Cox proportional hazards regression models and restricted cubic splines. The Fine–Gray subdistribution method was used to account for competing risks. Results During 6.9 (±0.9) years of follow-up, 6829 CVD and 2042 orthostatic circulatory disease events occurred. When stationary time exceeded 12 h/day, orthostatic circulatory disease risk was higher by an average HR (95% confidence interval) of 0.22 (0.16, 0.29) per hour. Every additional hour above 10 h/day of sitting was associated with a 0.26 (0.18, 0.36) higher risk. Standing more than 2 h/day was associated with an 0.11 (0.05, 0.18) higher risk for every additional 30 min/day. For major CVD, when stationary time exceeded 12 h/day, risk was higher by an average of 0.13 (0.10, 0.16) per hour. Sitting time was associated with a 0.15 (0.11, 0.19) higher risk per extra hour. Time spent standing was not associated with major CVD risk. Conclusions Time spent standing was not associated with CVD risk but was associated with higher orthostatic circulatory disease risk. Time spent sitting above 10 h/day was associated with both higher orthostatic circulatory disease and major CVD risk. The deleterious associations of overall stationary time were primarily driven by sitting. Collectively, our findings indicate increasing standing time as a prescription may not lower major CVD risk and may lead to higher orthostatic circulatory disease risk. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Prospective Association of Occupational and Leisure-Time Physical Activity With Cardiovascular Risk Factors in Early Adulthood: Findings From Pelotas (Brazil) 1982 Birth Cohort.

Author

de Lucena Alves, Charles Phillipe, Crochemore-Silva, Inácio, Lima, Natália P., Coenen, Pieter, and Horta, Bernardo Lessa

Subjects
CARDIOVASCULAR diseases risk factors, PHYSICAL activity, DIASTOLIC blood pressure, COHORT analysis, ADULTS, DYSLIPIDEMIA
Abstract

Background: The benefits of physical activity in health outcomes are well established. However, recent evidence suggests that benefits may differ by domain and population. Thus, we aimed to investigate the prospective association of occupational (OPA) and leisure-time physical activity (LTPA) with cardiovascular risk factors. Methods: In 1982, the maternity hospitals of Pelotas were visited daily; those live births whose families lived in urban areas were evaluated, and their mothers were later interviewed (n = 5914). In the 2004/5 follow-up (23 y old), both OPA and LTPA were measured in 4295 participants using their respective sections of the International Physical Activity Questionnaire. In the 2012 follow-up (30 y old), the following cardiovascular risk factors were collected: high-density lipoprotein (in milligrams per deciliter), low-density lipoprotein (in milligrams per deciliter), triglycerides (in milligrams per deciliter), glucose (in milligrams per deciliter), and blood pressure (in millimeters of mercury). Multivariable linear regressions were performed to evaluate associations between OPA and LTPA with these specific cardiovascular risk factors. Results: In total, 3241 participants were analyzed. Our main findings suggest that there was no association between OPA and LTPA with high- and low-density lipoprotein. There were inverse associations between OPA and lower levels of triglycerides among males (β = −0.002; 95% confidence interval, −0.003 to −0.000) and positive associations between LTPA and higher levels of diastolic blood pressure among females (β = 0.111; 95% confidence interval, 0.005–0.216). Conclusion: In conclusion, our findings suggest that there was no association, or association with limited clinical relevance, of OPA and LTPA with cardiovascular risk factors in early adulthood. [ABSTRACT FROM AUTHOR]

Published
2023
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26. (Cost‐)effectiveness of personalised multimodal physiotherapy compared to surgery in patients with cervical radiculopathy: A systematic review.

Author

Klein Heerenbrink, Sebastiaan, Coenen, Pieter, Coppieters, Michel W., van Dongen, Johanna M., Vleggeert‐Lankamp, Carmen L. A., Rooker, Servan, ter Meulen, Bastiaan C., Bosboom, Johannes L. W., Bouma, Gerrit J., Lutke Schipholt, Ivo J., Sleijser‐Koehorst, Marije L. S., de Vries, Ralph, Ostelo, Raymond W. J. G., and Scholten‐Peeters, Gwendolyne G. M.

Subjects
*PHYSICAL therapy, *MEDICAL information storage & retrieval systems, *PAIN measurement, *COST effectiveness, *CINAHL database, *NECK pain, *RADICULOPATHY, *SYSTEMATIC reviews, *MEDLINE, *QUALITY of life, *REOPERATION, *ONLINE information services, *ADVERSE health care events, *MEDICAL care costs, *PSYCHOLOGY information storage & retrieval systems, *RANGE of motion of joints, *EMPLOYMENT reentry
Abstract

Rationale: Cervical radiculopathy is initially typically managed conservatively. Surgery is indicated when conservative management fails or with severe/progressive neurological signs. Personalised multimodal physiotherapy could be a promising conservative strategy. However, aggregated evidence on the (cost‐)effectiveness of personalised multimodal physiotherapy compared to surgery with/without post‐operative physiotherapy is lacking. Aim/Objectives: To systematically summarise the literature on the (cost‐)effectiveness of personalised multimodal physiotherapy compared to surgery with or without post‐operative physiotherapy in patients with cervical radiculopathy. Methods: PubMed, Embase, CINAHL, PsycINFO and Web of Science were searched from inception to 1st of March 2023. Primary outcomes were effectiveness regarding costs, arm pain intensity and disability. Neck pain intensity, perceived recovery, quality of life, neurological symptoms, range‐of‐motion, return‐to‐work, medication use, (re)surgeries and adverse events were considered secondary outcomes. Randomised clinical trials comparing personalised multimodal physiotherapy versus surgical approaches with/without post‐operative physiotherapy were included. Two independent reviewers performed study selection, data‐extraction, and risk of bias assessment using the Cochrane RoB 2 and Consolidated Health Economic Evaluation Reporting Standards statement. Certainty of the evidence was determined using Grading of Recommendations, Assessment, Development and Evaluations. Results: From 2109 records, eight papers from two original trials, with 117 participants in total were included. Low certainty evidence showed there were no significant differences on arm pain intensity and disability, except for the subscale 'heavy work' related disability (12 months) and disability at 5–8 years. Cost‐effectiveness was not assessed. There was low certainty evidence that physiotherapy improved significantly less on neck pain intensity, sensory loss and perceived recovery compared to surgery with/without physiotherapy. Low certainty evidence showed there were no significant differences on numbness, range of motion, medication use, and quality of life. No adverse events were reported. Conclusion: Considering the clinical importance of accurate management recommendations and the current low level of certainty, high‐quality cost‐effectiveness studies are needed. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Should workers be physically active after work? Associations of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels—An individual participant data meta-analysis

Author

Cillekens, Bart, Coenen, Pieter, Huysmans, Maaike A., Holtermann, Andreas, Troiano, Richard P., Mork, Paul Jarle, Krokstad, Steinar, Clays, Els, De Bacquer, Dirk, Aadahl, Mette, Kårhus, Line Lund, Sjøl, Anette, Bo Andersen, Lars, Kauhanen, Jussi, Voutilainen, Ari, Pulsford, Richard, Stamatakis, Emmanuel, Goldbourt, Uri, Peters, Annette, Thorand, Barbara, Rosengren, Annika, Björck, Lena, Sprow, Kyle, Franzon, Kristin, Rodriguez-Barranco, Miguel, Luján-Barroso, Leila, Alfredsson, Lars, Bahls, Martin, Ittermann, Till, Wanner, Miriam, Bopp, Matthias, Marott, Jacob Louis, Schnohr, Peter, Nordestgaarda, Børge G., Dalene, Knut Eirik, Ekelund, Ulf, Clausen, Johan, Jensen, Magnus T., Petersen, Christina Bjørk, Krause, Niklas, Twisk, Jos, van Mechelen, Willem, and van der Beek, Allard J.

Published
2025
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30. Prognostic factors for return to work following knee arthroplasty

Author

Strijbos, Daniel O, additional, Straat, A Carlien, additional, van der Sluis, Geert, additional, Boymans, Tim, additional, Hoving, Jan L, additional, Pahlplatz, Thijs M.J., additional, Hoorntje, Alexander, additional, van Zaanen, Yvonne, additional, Coenen, Pieter, additional, Berenji, Manijeh, additional, Reneman, Michiel F, additional, and Kuijer, P Paul F M, additional

Published
2024
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35. Prognostic factors for return to work following knee arthroplasty

Author

Strijbos, Daniel O., Straat, A. Carlien, van der Sluis, Geert, Boymans, Tim, Hoving, Jan L., Pahlplatz, Thijs M.J., Hoorntje, Alexander, van Zaanen, Yvonne, Coenen, Pieter, Berenji, Manijeh, Reneman, Michiel F., Kuijer, P. Paul F.M., Strijbos, Daniel O., Straat, A. Carlien, van der Sluis, Geert, Boymans, Tim, Hoving, Jan L., Pahlplatz, Thijs M.J., Hoorntje, Alexander, van Zaanen, Yvonne, Coenen, Pieter, Berenji, Manijeh, Reneman, Michiel F., and Kuijer, P. Paul F.M.

Abstract

Objectives: This is a protocol for a Cochrane Review (prognosis). The objectives are as follows:. We will examine four prognostic factors for return to work that can be used to manage patient expectations, enhance shared decision-making, and improve timely, multidisciplinary, work-directed care. The research question Which of the following four prognostic factors, categorised according to the International Classification of Functioning, Disability and Health (ICF) framework, are associated with return to work after primary knee arthroplasty in patients with a paid job: type of arthroplasty (health condition), sick leave before surgery (participation), physically demanding work (environmental factors), and patient expectations regarding return to work (personal factors)?. PICOTS We define our PICOTS as (Riley 2019): Patients (P): individuals engaged in paid employment who actively choose primary total knee arthroplasty or unicondylar knee arthroplasty as a treatment option for knee osteoarthritis. Index prognostic factors (I): we will consider these prognostic factors. Type of arthroplasty Duration of sick leave prior to surgery Engagement in physically demanding work Person's expectations regarding recovery Comparator (C): Type of arthroplasty: unicondylar knee arthroplasty versus total knee arthroplasty Duration of sick leave prior to surgery: short-term versus long-term Engagement in physically demanding work: light versus medium and heavy knee-demanding work Patient expectations regarding recovery: positive versus negative Outcomes (O): the primary outcome is the return to work, which is further classified by: Nature of return to work: initial, full, or undefined; Method of measurement: Dichotomous (yes/no): short- and long-term return to work; Scale: duration of return to work. Time (T): prognostic factors will be assessed preoperatively. The outcome, i.e. return to work, is measured as dichotomous data (short- and long-term) and on a scale. Short-term (≤ 6 m

Published
2024

36. Mapping Contextual Factors Influencing Physical Activity Behavior of People with a Physical Demanding Job

Author

Beckmann, Julia (author), Coenen, Pieter (author), Speklé, Erwin (author), Kraal, J.J. (author), Beckmann, Julia (author), Coenen, Pieter (author), Speklé, Erwin (author), and Kraal, J.J. (author)

Abstract

People with a physically demanding job have an unhealthy disbalance in occupational and leisure-time physical activity (PA). We aimed to understand which contextual factors influence this disbalance, and explore opportunities for lifestyle interventions that could restore this disbalance. We applied a contextmapping study with six production workers from a Dutch coating department. Participants filled in a sensitizing booklet with PA-related activities, and were interviewed afterwards. Participants reported reasons for (not) being active in leisure-time using an experience sampling method. Our results indicate that main reasons for being inactive during leisure time were their believes that occupational PA is enough for a healthy lifestyle, and the need to rest after work. Results show that lifestyle interventions should tackle workers inadequate risk perception and over-exhaustion to empower them to shift their PA behavior in a healthier direction. This indicates the need for a holistic approach targeting both home and working environments., Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public., Applied Ergonomics and Design

Published
2024
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46. Re: Cillekens B, Huysmans MA, Holtermann A, van Mechelen W, Straker L, Krause N, van der Beek AJ, Coenen P. Physical activity at work may not be health enhancing. A systematic review with meta-analysis on the association between occupational physical activity and cardiovascular disease mortality covering 23 studies with 655 892 participants. Scand J Work Environ Health. 2022;48(2):86–98. doi:10.5271/sjweh.3993

Author

Cillekens, Bart, Huysmans, Maaike A., Holtermann, Andreas, van Mechelen, Willem, Straker, Leon, Krause, Niklas, van der Beek, Allard J., Coenen, Pieter, Public and occupational health, APH - Societal Participation & Health, APH - Health Behaviors & Chronic Diseases, and AMS - Musculoskeletal Health

Subjects
Public Health, Environmental and Occupational Health
Published
2023
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