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30 results on '"Cohen, Rachel E."'

9. All Hands on Deck: Local Public Health Agencies Leveraging the Incident Command System During Crises

Author

Baskin, Carole R., primary, Barry, Mark, additional, Cohen, Rachel E., additional, Condren, Colleen, additional, Crosley, Sarah, additional, Dickhans, Carrie D., additional, Donaldson, Kate, additional, Gardner, Sharon, additional, Griffin, Ken J. A., additional, Place, Arletta, additional, Doucette, Emily D., additional, and Schmidt, Spring, additional

Published
2021
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14. Contributors

Author

Blanvillain, Gaëlle, Carter, Amanda W., Cohen, Rachel E., DeNardo, Dale F., Gist, Daniel H., Johnson, Michele A., Jones, Susan M., Kohno, Satomi, Korzan, Wayne J., Kuchling, Gerald, Lind, Craig M., López, Pilar, Lovern, Matthew, Martín, José, Miles, Donald B., Milnes, Matthew R., Moore, Brandon C., Owens, David W., Paitz, Ryan T., Rosati, Luigi, Sinervo, Barry, Summers, Cliff H., Taylor, Emily N., and Wade, Juli

Published
2024
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18. Expression of aromatase and two isozymes of 5α-reductase in the developing green anole forebrain

Author

Cohen, Rachel E. and Wade, Juli

Subjects
Male, Cholestenone 5 alpha-Reductase, Sex Characteristics, Brain, Cell Count, Lizards, Amygdala, Preoptic Area, Article, Isoenzymes, Aromatase, Ventromedial Hypothalamic Nucleus, Animals, Female
Abstract

Neural steroids, as well as the enzymes that produce these hormones, are important for sexual differentiation of the brain during development. Aromatase converts testosterone into oestradiol. 5α-reductase converts testosterone to 5α-dihydrotestosterone and occurs in two isozymes: type 1 (5αR1) and type 2 (5αR2). Each of these enzymes is present in the developing brain in many species, although no work has been carried out examining the expression of all three enzymes in non-avian reptiles with genetic sex determination. In the present study, we evaluated mRNA expression of neural aromatase, 5αR1 and 5αR2, on the day of hatching and at day 50 in one such lizard, the green anole. We describe the distribution of these enzymes throughout the brain and the quantification of mRNA expression in three regions that control adult sexual behaviours: the preoptic area (POA) and ventromedial amygdala (AMY), which are involved in male displays, as well as the ventromedial hypothalamus, which regulates female receptivity. Younger animals had a greater number (POA) and density (AMY) of 5αR1 mRNA expressing cells. We detected no effects of sex or age on aromatase or 5αR2. In comparison with data from adults, the present results support the idea that the green anole forebrain has not completely differentiated by 50 days after hatching and that 5αR1 may play a role in the early development of regions important for masculine function.

Published
2012

21. Continuous Improvement in an NSF S-STEM Program.

Author

Kinzel, Rob Henry, Nykanen, Deborah K., Bates, Rebecca A., Sealy, Winston, Cohen, Rachel E., and Veltsos, Jennifer

Subjects
STEM education, ENGINEERING education, PROFESSIONAL education, SCHOLARSHIPS
Abstract

The article discusses the continuous improvement in STEM education system scholarship program of National Science Foundation (U.S.). This program is designed for STEM students and addresses key professional education area. The student scholars receive financial support and opportunity to develop academic, professional and life skills through a weekly scholars seminar.

Published
2015

30. Distribution of Two Isozymes of 5α-Reductase in the Brains of Adult Male and Female Green Anole Lizards.

Author

Cohen, Rachel E. and Wade, Juli

Subjects
*ISOENZYMES, *LIZARDS, *BRAIN, *MALES, *FEMALES, *TESTOSTERONE, *ANIMAL sexual behavior
Abstract

The 5α-reductase (5αR) enzyme converts testosterone to 5α-dihydrotestosterone. This local metabolism within the brain is important for the full expression of male sexual behavior in many species, including green anole lizards. Two isozymes of 5αR exist and little is known about their specific distributions. We conducted in situ hybridization for both isozymes in intact male and female green anole brains during the breeding (BS) and non-breeding (NBS) seasons. 5αR1 mRNA was only detected in the brainstem, while 5αR2 was expressed in specific areas throughout the brain. As our primary interest was evaluating the potential role of 5αR in forebrain regulation of reproductive behavior, we quantified 5αR2 expression in the preoptic area, amygdala (AMY), and ventromedial hypothalamus (VMH). More 5αR2 cells were detected during the NBS than BS in the AMY, and the density of these cells was greater in females than males. In the VMH, the right side contained more 5αR2 cells than the left, an effect driven by a lateralized increase in the NBS. These data expand understanding of the distribution and potential roles of both isozymes in the adult brain, and differences in expression patterns between mammals and birds suggest that they may have been co-opted for different functions later in evolution. Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2011
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