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2. Development and Valuation of a Preference-Weighted Measure in Age-Related Macular Degeneration From the Vision Impairment in Low Luminance Questionnaire: A MACUSTAR Report

Author

Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P.G., Behning, C., Belmouhand, M., Berger, M., Binns, A., Boon, C.J.F., Böttger, M., Bouchet, C., Brazier, J.E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D.P., Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Finger, R.P., Fletcher, E., Floyd, H., Francisco, C., Gutfleisch, M., Hogg, R., Holz, F.G., Hoyng, C.B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Leal, S., Lechanteur, Y.T.E., Luhmann, U.F.O., Lüning, A., Marques, I., Martinho, C., Montesano, G., Mulyukov, Z., Paques, M., Parodi, B., Parravano, M., Penas, S., Peters, T., Peto, T., Pfau, M., Poor, S., Priglinger, S., Rowen, D., Rubin, G.S., Sahel, J., Sanches Fernandes, D., Sánchez, C., Sander, O., Saßmannshausen, M., Schmid, M., Schmitz-Valckenberg, S., Schrinner-Fenske, H., Siedlecki, J., Silva, R., Skelly, A., Souied, E., Staurenghi, G., Stöhr, L., Tavares, D., Tavares, J., Taylor, D.J., Terheyden, J.H., Thiele, S., Tufail, A., Varano, M., Vieweg, L., Werner, J., Wintergerst, L., Wolf, A., Zakaria, N., Rowen, Donna, Carlton, Jill, Terheyden, Jan H., Finger, Robert P., Wickramasekera, Nyantara, and Brazier, John

Published
2024
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4. Dimension six FCNC operators and top production at the LHC

Author

Coimbra, R. A., Ferreira, P. M., Guedes, R. B., Oliveira, O., Onofre, A., Santos, R., and Won, Miguel

Subjects
High Energy Physics - Phenomenology
Abstract

In this work we calculate the effects of the electroweak flavour changing neutral currents dimension six effective operators on single top production at the LHC. These results are then combined with previous ones we have obtained for the strong sector. This allow us, for the first time, to perform a combined analysis of flavour changing neutral currents in top production with all contributing dimension six operators. Finally, we study the feasibility of their observation and characterization both at the Tevatron and at the LHC., Comment: 16 pages, 13 figures

Published
2008
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5. Charmonium and Bottomonium from Classical SU(3) Gauge Configurations

Author

Coimbra, R. A. and Oliveira, O.

Subjects
High Energy Physics - Phenomenology
Abstract

The charmonium and bottomonium spectra computed from a potential defined from a single gauge configuration, obtained from solving the classical field equations, is discussed. The theoretical spectra shows good agreement with the measured states. A discussion of possible interpretations, within the same non-relativistic potential model, for the new charmonia states X(3872), $\chi_{c1} (2P)$ and Y(4260) is performed. In particular, we give predictions for electromagnetic E1 transitions for various scenarios., Comment: Talk given at "Quark Confinement and the Hadron Spectrum VII", Ponta Delgada, Sao Miguel, Azores, Portugal, Sept. 2-7, 2006

Published
2006
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6. Heavy Quarkonia from Classical SU(3) Yang-Mills Configurations

Author

Coimbra, R. A. and Oliveira, O.

Subjects
High Energy Physics - Phenomenology
Abstract

A generalized Cho-Faddeev-Niemi ansatz for SU(3) Yang-Mills is investigated. The corresponding classical field equations are solved for its simplest parametrization. From these solutions it is possible to define a confining central non-relativistic potential used to study heavy quarkonia. The associated spectra reproduces the experimental spectra with an error of less than 3% for charmonium and 1% for bottomonium. Moreover, the recently discovered new charmonium states can be accomodate in the spectra, keeping the same level of precision. The leptonic width show good agreement with the recent measurements. The charmonium and bottomonium E1 electromagnetic transitions widths are computed and compared with the experimental values., Comment: 3 pages. Talk at QNP06, 5th-10th June, Madrid, Spain

Published
2006
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7. Charmonium from Classical Pure SU(3) Yang-Mills Configurations

Author

Oliveira, O. and Coimbra, R. A.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

A generalized Faddeev-Niemi ansatz for the gluon field is discussed. In its simplest parametrization, the ansatz allows a solution of the classical SU(3) Yang-Mills equations. From these solutions a confining potential for heavy quarkonia is defined. The investigation of charmonium spectra proves that the potential is able to reproduce the experimental spectra at the level of 3%. Moreover, charmonium leptonic and strong decays are investigated. The results are in fair agreement with experimental figures and are in line with other quark model calculations., Comment: Substantial rewriting

Published
2006

9. Classical Solutions of SU(2) and SU(3) Pure Yang-Mills Theories and Heavy Quark Spectrum

Author

Oliveira, O. and Coimbra, R. A.

Subjects
High Energy Physics - Phenomenology
Abstract

In this paper we compute classical Minkowsky spacetime solutions of pure SU(2) and SU(3) gauge theories, in Landau gauge. The solutions are regular everywhere except at the origin and/or infinity, are characterized by a four momentum $k$ such that $k^2 = 0$ and resemble QED configurations. The classical solutions suggest a particle-independent description of hadrons, similarly to the Atomic and Nuclear energy levels, which is able to reproduce the heavy quarkonium spectrum with a precision below 10%. Typical errors in the theoretical mass prediction relative to the measured mass being of the order of 2-4%., Comment: New version includes acknowledges

Published
2003

10. Classical Solutions of SU(3) Pure Yang-Mills Theory

Author

Oliveira, O. and Coimbra, R. A.

Subjects
High Energy Physics - Theory
Abstract

Regular classical solutions of pure SU(3) gauge theories, in Minkowsky spacetime, are computed in the Landau gauge. The classical fields have an intrinsic energy scale and produce quark confinement if interpreted in the sense of a nonrelativistic potential. Moreover, the quark propagator in the background of these fields vanishes at large positive and negative time and space separations., Comment: 10 pages, 1figure

Published
2002

11. A phage-targeting strategy for the design of spatiotemporal drug delivery from grafted matrices

Author

Sawada, R, Peterson, CY, Gonzalez, AM, Potenza, BM, Mueller, B, Coimbra, R, Eliceiri, BP, and Baird, A

Abstract

Background: The natural response to injury is dynamic and normally consists of complex temporal and spatial cellular changes in gene expression, which, when acting in synchrony, result in patent tissue repair and, in some instances, regeneration. However, current therapeutic regiments are static and most rely on matrices, gels and engineered skin tissue. Accordingly, there is a need to design next-generation grafting materials to enable biotherapeutic spatiotemporal targeting from clinically approved matrices. To this end, rather then focus on developing completely new grafting materials, we investigated whether phage display could be deployed onto clinically approved synthetic grafts to identify peptide motifs capable of linking pharmaceutical drugs with differential affinities and eventually, control drug delivery from matrices over both space and time.Methods: To test this hypothesis, we biopanned combinatorial peptide libraries onto different formulations of a wound-healing matrix (Integra®) and eluted the bound peptides with 1) high salt, 2) collagen and glycosaminoglycan or 3) low pH. After three to six rounds of biopanning, phage recovery and phage amplification of the bound particles, any phage that had acquired a capacity to bind the matrix was sequenced.Results: In this first report, we identify distinct classes of matrix-binding peptides which elute differently from the screened matrix and demonstrate that they can be applied in a spatially relevant manner.Conclusions: We suggest that further applications of these combinatorial techniques to wound-healing matrices may offer a new way to improve the performance of clinically approved matrices so as to introduce temporal and spatial control over drug delivery. © 2011 Sawada et al; licensee BioMed Central Ltd.

Published
2011

12. Ecrg4 expression and its product augurin in the choroid plexus: Impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury

Author

Gonzalez, AM, Podvin, S, Lin, SY, Miller, MC, Botfield, H, Leadbeater, WE, Roberton, A, Dang, X, Knowling, SE, Cardenas-Galindo, E, Donahue, JE, Stopa, EG, Johanson, CE, Coimbra, R, Eliceiri, BP, and Baird, A

Abstract

Background: The content and composition of cerebrospinal fluid (CSF) is determined in large part by the choroid plexus (CP) and specifically, a specialized epithelial cell (CPe) layer that responds to, synthesizes, and transports peptide hormones into and out of CSF. Together with ventricular ependymal cells, these CPe relay homeostatic signals throughout the central nervous system (CNS) and regulate CSF hydrodynamics. One new candidate signal is augurin, a newly recognized 14 kDa protein that is encoded by esophageal cancer related gene-4 (Ecrg4), a putative tumor suppressor gene whose presence and function in normal tissues remains unexplored and enigmatic. The aim of this study was to explore whether Ecrg4 and its product augurin, can be implicated in CNS development and the response to CNS injury.Methods: Ecrg4 gene expression in CNS and peripheral tissues was studied by in situ hybridization and quantitative RT-PCR. Augurin, the protein encoded by Ecrg4, was detected by immunoblotting, immunohistochemistry and ELISA. The biological consequence of augurin over-expression was studied in a cortical stab model of rat CNS injury by intra-cerebro-ventricular injection of an adenovirus vector containing the Ecrg4 cDNA. The biological consequences of reduced augurin expression were evaluated by characterizing the CNS phenotype caused by Ecrg4 gene knockdown in developing zebrafish embryos.Results: Gene expression and immunohistochemical analyses revealed that, the CP is a major source of Ecrg4 in the CNS and that Ecrg4 mRNA is predominantly localized to choroid plexus epithelial (CPe), ventricular and central canal cells of the spinal cord. After a stab injury into the brain however, both augurin staining and Ecrg4 gene expression decreased precipitously. If the loss of augurin was circumvented by over-expressing Ecrg4 in vivo, BrdU incorporation by cells in the subependymal zone decreased. Inversely, gene knockdown of Ecrg4 in developing zebrafish embryos caused increased proliferation of GFAP-positive cells and induced a dose-dependent hydrocephalus-like phenotype that could be rescued by co-injection of antisense morpholinos with Ecrg4 mRNA.Conclusion: An unusually elevated expression of the Ecrg4 gene in the CP implies that its product, augurin, plays a role in CP-CSF-CNS function. The results are all consistent with a model whereby an injury-induced decrease in augurin dysinhibits target cells at the ependymal-subependymal interface. We speculate that the ability of CP and ependymal epithelium to alter the progenitor cell response to CNS injury may be mediated, in part by Ecrg4. If so, the canonic control of its promoter by DNA methylation may implicate epigenetic mechanisms in neuroprogenitor fate and function in the CNS. © 2011 Gonzalez et al; licensee BioMed Central Ltd.

Published
2011

13. WSES consensus guidelines on sigmoid volvulus management

Author

Tian, B.W.C.A., Vigutto, G., Tan, E.C.T.H., Goor, H. van, Bendinelli, C., Abu-Zidan, F., Ivatury, R., Sakakushev, B., Carlo, I. Di, Sganga, G., Maier, R.V., Coimbra, R., Leppäniemi, A., Litvin, A., Damaskos, D., Broek, R.P.G ten, Biffl, W., Saverio, S. Di, Simone, B. De, Ceresoli, M., Picetti, E., Galante, J., Tebala, G.D., Beka, S.G., Bonavina, L., Cui, Y., Khan, J., Cicuttin, E., Amico, F., Kenji, I., Hecker, A., Ansaloni, L., Sartelli, M., Moore, E.E., Kluger, Y., Testini, M., Weber, D., Agnoletti, V., Angelis, N.D., Coccolini, F., Sall, I., Catena, F., Tian, B, Vigutto, G, Tan, E, van Goor, H, Bendinelli, C, Abu-Zidan, F, Ivatury, R, Sakakushev, B, Di Carlo, I, Sganga, G, Maier, R, Coimbra, R, Leppaniemi, A, Litvin, A, Damaskos, D, Broek, R, Biffl, W, Di Saverio, S, De Simone, B, Ceresoli, M, Picetti, E, Galante, J, Tebala, G, Beka, S, Bonavina, L, Cui, Y, Khan, J, Cicuttin, E, Amico, F, Kenji, I, Hecker, A, Ansaloni, L, Sartelli, M, Moore, E, Kluger, Y, Testini, M, Weber, D, Agnoletti, V, Angelis, N, Coccolini, F, Sall, I, and Catena, F

Subjects
Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], All institutes and research themes of the Radboud University Medical Center, Emergency Medicine, sigmoid volvolus, Surgery
Abstract

Contains fulltext : 293045.pdf (Publisher’s version ) (Open Access) Sigmoid volvulus is a common surgical emergency, especially in elderly patients. Patients can present with a wide range of clinical states: from asymptomatic, to frank peritonitis secondary to colonic perforation. These patients generally need urgent treatment, be it endoscopic decompression of the colon or an upfront colectomy. The World Society of Emergency Surgery united a worldwide group of international experts to review the current evidence and propose a consensus guidelines on the management of sigmoid volvulus.

Published
2023

14. The new timing in acute care surgery (new TACS) classification: a WSES Delphi consensus study

Author

De Simone B., Kluger Y., Moore E. E., Sartelli M., Abu-Zidan F. M., Coccolini F., Ansaloni L., Tebala G. D., Di Saverio S., Di Carlo I., Sakakushev B. E., Bonavina L., Sugrue M., Galante J. M., Ivatury R., Picetti E., Chirica M., Wani I., Bala M., Sall I., Kirkpatrick A. W., Shelat V. G., Pikoulis E., Leppäniemi A., Tan E., Broek R. P. G. t., Gurmu Beka S., Litvin A., Chouillard E., Coimbra R., Cui Y., De’ Angelis N., Sganga G., Stahel P. F., Agnoletti V., Rampini A., Shelat V., Damaskos D., Carcoforo P., Biffl W. L., Hecker A., Kirkpatrick A., Di Salomone S., Balogh Z., Beka S. G., Broek R. T., Velmahos G., Sakakushev B., Ceresoli M., Chiara O., Stahel P., Leppaniemi A., Marzi I., Inaba K., Khokha V., Reva V., Khan M., Toro A., de’ Angelis N., Malangoni M., Scozzafava E., Civil I., Maier R., Weber D., Chiarugi M., Soreide K., Testini M., Bravi F., Maier R. V., Catena F., De Simone, B, Kluger, Y, Moore, E, Sartelli, M, Abu-Zidan, F, Coccolini, F, Ansaloni, L, Tebala, G, Di Saverio, S, Di Carlo, I, Sakakushev, B, Bonavina, L, Sugrue, M, Galante, J, Ivatury, R, Picetti, E, Chirica, M, Wani, I, Bala, M, Sall, I, Kirkpatrick, A, Shelat, V, Pikoulis, E, Leppäniemi, A, Tan, E, Broek, R, Gurmu Beka, S, Litvin, A, Chouillard, E, Coimbra, R, Cui, Y, De’ Angelis, N, Sganga, G, Stahel, P, Agnoletti, V, Rampini, A, Damaskos, D, Carcoforo, P, Biffl, W, Hecker, A, Di Salomone, S, Balogh, Z, Beka, S, Velmahos, G, Ceresoli, M, Chiara, O, Leppaniemi, A, Marzi, I, Inaba, K, Khokha, V, Reva, V, Khan, M, Toro, A, de’ Angelis, N, Malangoni, M, Scozzafava, E, Civil, I, Maier, R, Weber, D, Chiarugi, M, Soreide, K, Testini, M, Bravi, F, and Catena, F

Subjects
Healthcare system, Delay in surgery, Operating room management, Delphi method, Emergency surgery, Priority, Time to surgery, Timing in acute care surgery (TACS), Triage, Classification
Abstract

Background: Timely access to the operating room for emergency general surgery (EGS) indications remains a challenge across the globe, largely driven by operating room availability and staffing constraints. The “timing in acute care surgery” (TACS) classification was previously published to introduce a new tool to triage the timely and appropriate access of EGS patients to the operating room. However, the clinical and operational effectiveness of the TACS classification has not been investigated in subsequent validation studies. This study aimed to improve the TACS classification and provide further consensus around the appropriate use of the new TACS classification through a standardized Delphi approach with international experts. Methods: This is a validation study of the new TACS by a selected international panel of experts using the Delphi method. The TACS questionnaire was designed as a web-based survey. The consensus agreement level was established to be ≥ 75%. The collective consensus agreement was defined as the sum of the percentage of the highest Likert scale levels (4–5) out of all participants. Surgical emergency diseases and correlated clinical scenarios were defined for each of the proposed classes. Subsequent rounds were carried out until a definitive level of consensus was reached. Frequencies and percentages were calculated to determine the degree of agreement for each surgical disease. Results: Four polling rounds were carried out. The new TACS classification provides 6 colour-code classes correlated to a precise timing to surgery, defined scenarios and surgical condition. The WHITE colour-code class was introduced to rapidly (within a week) reschedule cancelled or postponed surgical procedures. Haemodynamic stability is the main tool to stratify patients for immediate surgery or not in the presence of sepsis/septic shock. Fifty-one surgical diseases were included in the different colour-code classes of priority. Conclusion: The new TACS classification is a comprehensive, simple, clear and reproducible triage system which can be used to assess the severity of the patient and the surgical disease, to reduce the time to access to the operating room, and to manage the emergency surgical patients within a “safe” timeframe. By including well-defined surgical diseases in the different colour-code classes of priority, validated through a Delphi consensus, the new TACS improves communication among surgeons, between surgeons and anaesthesiologists and decreases conflicts and waste and waiting time in accessing the operating room for emergency surgical patients.

Published
2023

15. Genetic markers associated with divergent selection against the parasite Marteilia cochillia in common cockle (Cerastoderma edule) using transcriptomics and population genomics data

Author

Pampín, M., primary, Casanova, A., additional, Fernández, C., additional, Blanco, A., additional, Hermida, M., additional, Vera, M., additional, Pardo, B. G., additional, Coimbra, R. M., additional, Cao, A., additional, Iglesias, D., additional, Carballal, M.J., additional, Villalba, A., additional, and Martínez, P., additional

Published
2023
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16. Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report

Author

Garzone, Davide, Terheyden, Jan Henrik, Morelle, Olivier, Wintergerst, Maximilian W.M., Saßmannshausen, Marlene, Schmitz-Valckenberg, Steffen, Pfau, Maximilian, Thiele, Sarah, Poor, Stephen, Leal, Sergio, Holz, Frank G., Finger, Robert P., Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P. G., Behning, C., Belmouhand, M., Berger, M., Binns, A., Boon, C. J.F., Böttger, M., Bouchet, C., Brazier, J. E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D. P., Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Fletcher, E., Francisco, C., Gutfleisch, M., Hogg, R., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Lechanteur, Y. T.E., Luhmann, U. F.O., Lüning, A., Schmid, M., Ophthalmology, Amsterdam Neuroscience - Complex Trait Genetics, Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P. G., Behning, C., Belmouhand, M., Berger, M., Binns, A., Boon, C. J. F., Böttger, M., Bouchet, C., Brazier, J. E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D. P., Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Fletcher, E., Francisco, C., Gutfleisch, M., Hogg, R., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Lechanteur, Y. T. E., Luhmann, U. F. O., Lüning, A., Marques, I., Martinho, C., Montesano, G., Mulyukov, Z., Paques, M., Parodi, B., Parravano, M., Penas, S., Peters, T., Peto, T., Priglinger, S., Rowen, D., Rubin, G. S., Sahel, J., Sánchez, C., Sander, O., Schmid, M., Schrinner-Fenske, H., Siedlecki, J., Silva, R., Skelly, A., Souied, E., Staurenghi, G., Stöhr, L., Taylor, D. J., Tufail, A., Varano, M., Vieweg, L., Wintergerst, L., Wolf, A., and Zakaria, N.

Subjects
diagnosis [Macular Degeneration], methods [Tomography, Optical Coherence], Fovea Centralis, Multidisciplinary, Humans, ddc:600, Retina, Software
Abstract

Drusen are hallmarks of early and intermediate age-related macular degeneration (AMD) but their quantification remains a challenge. We compared automated drusen volume measurements between different OCT devices. We included 380 eyes from 200 individuals with bilateral intermediate (iAMD, n = 126), early (eAMD, n = 25) or no AMD (n = 49) from the MACUSTAR study. We assessed OCT scans from Cirrus (200 × 200 macular cube, 6 × 6 mm; Zeiss Meditec, CA) and Spectralis (20° × 20°, 25 B-scans; 30° × 25°, 241 B-scans; Heidelberg Engineering, Germany) devices. Sensitivity and specificity for drusen detection and differences between modalities were assessed with intra-class correlation coefficients (ICCs) and mean difference in a 5 mm diameter fovea-centered circle. Specificity was > 90% in the three modalities. In eAMD, we observed highest sensitivity in the denser Spectralis scan (68.1). The two different Spectralis modalities showed a significantly higher agreement in quantifying drusen volume in iAMD (ICC 0.993 [0.991–0.994]) than the dense Spectralis with Cirrus scan (ICC 0.807 [0.757–0.847]). Formulae for drusen volume conversion in iAMD between the two devices are provided. Automated drusen volume measures are not interchangeable between devices and softwares and need to be interpreted with the used imaging devices and software in mind. Accounting for systematic difference between methods increases comparability and conversion formulae are provided. Less dense scans did not affect drusen volume measurements in iAMD but decreased sensitivity for medium drusen in eAMD.Trial registration: ClinicalTrials.gov NCT03349801. Registered on 22 November 2017.

Published
2022

19. The new timing in acute care surgery (new TACS) classification: a WSES Delphi consensus study

Author

Simone, B. De, Kluger, Y., Moore, E.E., Sartelli, M., Abu-Zidan, F.M., Coccolini, F., Ansaloni, L., Tebala, G.D., Saverio, S. Di, Carlo, I. Di, Sakakushev, B.E., Bonavina, L., Sugrue, M., Galante, J.M., Ivatury, R., Picetti, E., Chirica, M., Wani, I., Bala, M., Sall, I., Kirkpatrick, A.W., Shelat, V.G., Pikoulis, E., Leppäniemi, A., Tan, E., Broek, R.P.G ten, Gurmu Beka, S., Litvin, A., Chouillard, E., Coimbra, R., Cui, Y., De' Angelis, N., Sganga, G., Stahel, P.F., Agnoletti, V., Rampini, A., Testini, M., Bravi, F., Maier, R.V., Biffl, W.L., and Catena, F.

Subjects
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], All institutes and research themes of the Radboud University Medical Center
Abstract

Contains fulltext : 292357.pdf (Publisher’s version ) (Open Access) BACKGROUND: Timely access to the operating room for emergency general surgery (EGS) indications remains a challenge across the globe, largely driven by operating room availability and staffing constraints. The "timing in acute care surgery" (TACS) classification was previously published to introduce a new tool to triage the timely and appropriate access of EGS patients to the operating room. However, the clinical and operational effectiveness of the TACS classification has not been investigated in subsequent validation studies. This study aimed to improve the TACS classification and provide further consensus around the appropriate use of the new TACS classification through a standardized Delphi approach with international experts. METHODS: This is a validation study of the new TACS by a selected international panel of experts using the Delphi method. The TACS questionnaire was designed as a web-based survey. The consensus agreement level was established to be ≥ 75%. The collective consensus agreement was defined as the sum of the percentage of the highest Likert scale levels (4-5) out of all participants. Surgical emergency diseases and correlated clinical scenarios were defined for each of the proposed classes. Subsequent rounds were carried out until a definitive level of consensus was reached. Frequencies and percentages were calculated to determine the degree of agreement for each surgical disease. RESULTS: Four polling rounds were carried out. The new TACS classification provides 6 colour-code classes correlated to a precise timing to surgery, defined scenarios and surgical condition. The WHITE colour-code class was introduced to rapidly (within a week) reschedule cancelled or postponed surgical procedures. Haemodynamic stability is the main tool to stratify patients for immediate surgery or not in the presence of sepsis/septic shock. Fifty-one surgical diseases were included in the different colour-code classes of priority. CONCLUSION: The new TACS classification is a comprehensive, simple, clear and reproducible triage system which can be used to assess the severity of the patient and the surgical disease, to reduce the time to access to the operating room, and to manage the emergency surgical patients within a "safe" timeframe. By including well-defined surgical diseases in the different colour-code classes of priority, validated through a Delphi consensus, the new TACS improves communication among surgeons, between surgeons and anaesthesiologists and decreases conflicts and waste and waiting time in accessing the operating room for emergency surgical patients.

Published
2023

20. Characteristics and Spatial Distribution of Structural Features in Age-Related Macular Degeneration

Author

Saßmannshausen, Marlene, primary, Behning, Charlotte, additional, Weinz, Jonas, additional, Goerdt, Lukas, additional, Terheyden, Jan H., additional, Chang, Petrus, additional, Schmid, Matthias, additional, Poor, Stephen H., additional, Zakaria, Nadia, additional, Finger, Robert P., additional, Holz, Frank G., additional, Pfau, Maximilian, additional, Schmitz-Valckenberg, Steffen, additional, Thiele, Sarah, additional, Agostini, H., additional, Altay, L., additional, Atia, R., additional, Bandello, F., additional, Basile, P.G., additional, Behning, C., additional, Belmouhand, M., additional, Berger, M., additional, Binns, A., additional, Boon, C.J.F., additional, Böttger, M., additional, Bouchet, C., additional, Brazier, J.E., additional, Butt, T., additional, Carapezzi, C., additional, Carlton, J., additional, Carneiro, A., additional, Charil, A., additional, Coimbra, R., additional, Cozzi, M., additional, Crabb, D.P., additional, Cunha-Vaz, J., additional, Dahlke, C., additional, de Sisternes, L., additional, Dunbar, H., additional, Finger, R.P., additional, Fletcher, E., additional, Floyd, H., additional, Francisco, C., additional, Gutfleisch, M., additional, Hogg, R., additional, Holz, F.G., additional, Hoyng, C.B., additional, Kilani, A., additional, Krätzschmar, J., additional, Kühlewein, L., additional, Larsen, M., additional, Leal, S., additional, Lechanteur, Y.T.E., additional, Luhmann, U.F.O., additional, Lüning, A., additional, Marques, I., additional, Martinho, C., additional, Montesano, G., additional, Mulyukov, Z., additional, Paques, M., additional, Parodi, B., additional, Parravano, M., additional, Penas, S., additional, Peters, T., additional, Peto, T., additional, Pfau, M., additional, Poor, S., additional, Priglinger, S., additional, Rowen, D., additional, Rubin, G.S., additional, Sahel, J., additional, Sánchez, C., additional, Sander, O., additional, Saßmannshausen, M., additional, Schmid, M., additional, Schmitz-Valckenberg, S., additional, Schrinner-Fenske, H., additional, Siedlecki, J., additional, Silva, R., additional, Skelly, A., additional, Souied, E., additional, Staurenghi, G., additional, Stöhr, L., additional, Taylor, D.J., additional, Terheyden, J.H., additional, Thiele, S., additional, Tufail, A., additional, Varano, M., additional, Vieweg, L., additional, Wintergerst, L., additional, Wolf, A., additional, and Zakaria, N., additional

Published
2022
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22. Correction: Operative management of acute abdomen after bariatric surgery in the emergency setting: the OBA guidelines (World Journal of Emergency Surgery, (2022), 17, 1, (51), 10.1186/s13017-022-00452-w)

Author

De Simone B., Chouillard E., Ramos A. C., Donatelli G., Pintar T., Gupta R., Renzi F., Mahawar K., Madhok B., Maccatrozzo S., Abu-Zidan F. M., Moore E. E., Weber D. G., Coccolini F., Di Saverio S., Kirkpatrick A., Shelat V. G., Amico F., Pikoulis E., Ceresoli M., Galante J. M., Wani I., De'Angelis N., Hecker A., Sganga G., Tan E., Balogh Z. J., Bala M., Coimbra R., Damaskos D., Ansaloni L., Sartelli M., Pararas N., Kluger Y., Chahine E., Agnoletti V., Fraga G., Biffl W. L., Catena F., De Simone B., Chouillard E., Ramos A.C., Donatelli G., Pintar T., Gupta R., Renzi F., Mahawar K., Madhok B., Maccatrozzo S., Abu-Zidan F.M., Moore E.E., Weber D.G., Coccolini F., Di Saverio S., Kirkpatrick A., Shelat V.G., Amico F., Pikoulis E., Ceresoli M., Galante J.M., Wani I., De'Angelis N., Hecker A., Sganga G., Tan E., Balogh Z.J., Bala M., Coimbra R., Damaskos D., Ansaloni L., Sartelli M., Pararas N., Kluger Y., Chahine E., Agnoletti V., Fraga G., Biffl W.L., and Catena F.

Subjects
acute abdomen, bariatric surgery, emergency, guidelines
Abstract

Following publication of the original article [1], the co-author “Nikolaos Pararas” has misspelled wrongly as “Nikolaos Parasas”. The original article has been corrected.

Published
2022

23. Trauma quality indicators: internationally approved core factors for trauma management quality evaluation

Author

Coccolini, F., Kluger, Y., Moore, E. E., Maier, R. V., Coimbra, R., Ordonez, C., Ivatury, R., Kirkpatrick, A. W., Biffl, W., Sartelli, M., Hecker, A., Ansaloni, L., Leppaniemi, A., Reva, V., Civil, I., Vega, F., Chiarugi, M., Chichom-Mefire, A., Sakakushev, B., Peitzman, A., Chiara, O., Abu-Zidan, F., Maegele, M., Miccoli, M., Chirica, M., Khokha, V., Sugrue, M., Fraga, G. P., Otomo, Y., Baiocchi, G. L., Catena, F., Kuliesius, Z., Conti, L., Dogjani, A., Lee, J. G., Consani, H., Russello, D., Bortul, M., Maurel, T. G., Kaf, H. S., Adamou, H., Alin, V., Robustelli, U., Sato, N., Seretis, C., Quiodettis, M., Gomes, C. A., Kong, V., Zakaria, A. D., Guner, A., Gachabayov, M., Chowdhury, S., Pata, F., Garcia, A., Rems, M., Das, K., Riedel, J. G., Lasithiotakis, K., Sydorchuk, R., Sydorchuk, L., Lostoridis, E., Buia, A., Mcfarlane, M., Ciani, R., Munoz-Cruzado, V. M. D., Tartaglia, D., Ioannidis, O., Muhrbeck, M., Reicher, M., Roscio, F., Ceresoli, M., Tsiftsis, D., Kavalakat, A., Pintar, T., Georgiou, G., Ricci, G., Mohan, R., Saar, S., Di Carlo, I., Isik, A., Ahmed, A. Y. Y. M., Gonsaga, R. A. T., Sammartano, F., Tallon-Aguilar, L., Shoko, T., Hsu, J., Kobe, Y., Romeo, C. G. L., Podda, M., Mingoli, A., Delgado, R. C., Ekwen, G., Aude, V., Olona, C., Boati, P., Magnone, S., Capaldi, M., Bala, M., Picetti, E., Negoi, I., Kok, K. Y. Y., Jusoh, A. C., Amato, B., Nita, G. E., de Beaux, A., Demetrashvili, Z., Davies, R. J., Kim, J. I., Pereira, A., Fattori, L., Paolillo, C., Ghannam, W., Rodriguez, F. M., Berardi, L., Florio, M. G., Hecker, M., Dubuisson, V., O'Connor, D. B., De'Angelis, N., Dobric, I., Massalou, D., Ortenwall, P., Pikoulis, E., Ugarte-Sierra, B., Zuidema, W. P., Kechagias, A., Marwah, S., Litvin, A., Nikolopoulos, I., Pesce, A., Uranues, S., Luppi, D., Flohe, S., Martinez-Perez, A., Lorenzo, M., Vergano, L. B., Manca, M., Malacarne, P., Kurihara, H., Widder, S., Pucciarelli, M., Monzani, F., Brambillasca, P., Corbella, D., Agresta, F., Moore, L., Buonomo, L. A., Adeleye, A. O., Kim, D., Veroux, M., Hardcastle, T. C., Di Saverio, S., Recordare, A., Rubio-Perez, I., Shlyapnikov, S., Rahim, R., Vega, G. M. M., Boris, K., Sawyer, R., Baraket, O., Soreide, K., Weber, C., Seak, C. -J., Herman, S., Gamberini, E., Costa, S., Mazzocconi, G., Lozada, E., Manatakis, D., Lohsiriwat, V., Ahmed, A., Elbery, B., Tiberio, G. A. M., Santini, M., Mellace, L., Enoksen, C. H., Major, P., Parini, D., Improta, M., Fugazzola, P., Pini, S., Liberti, G., Martino, C., Cobianchi, L., Canzi, G., Cicuttin, E., Kenig, J., Zago, M., Giannessi, S., Scaglione, M., Orsitto, E., Cioni, R., Ghiadoni, L., Menichetti, F., Agnoletti, V., Sganga, G., Prosperi, P., Roviello, F., De Paolis, P., Gordini, G., Forfori, F., Ruscelli, P., Gabrielli, F., Puglisi, A., Bertolucci, A., Marchi, S., Bellini, M., Casagli, S., De Simone, B., Carmassi, F., Marchetti, S., Accorsini, M., Cremonini, C., Morelli, F., Romeo, L., Coccolini F., Kluger Y., Moore E.E., Maier R.V., Coimbra R., Ordonez C., Ivatury R., Kirkpatrick A.W., Biffl W., Sartelli M., Hecker A., Ansaloni L., Leppaniemi A., Reva V., Civil I., Vega F., Chiarugi M., Chichom-Mefire A., Sakakushev B., Peitzman A., Chiara O., Abu-Zidan F., Maegele M., Miccoli M., Chirica M., Khokha V., Sugrue M., Fraga G.P., Otomo Y., Baiocchi G.L., Catena F., Kuliesius Z., Conti L., Dogjani A., Lee J.G., Consani H., Russello D., Bortul M., Maurel T.G., Kaf H.S., Adamou H., Alin V., Robustelli U., Sato N., Seretis C., Quiodettis M., Gomes C.A., Kong V., Zakaria A.D., Guner A., Gachabayov M., Chowdhury S., Pata F., Garcia A., Rems M., Das K., Riedel J.G., Lasithiotakis K., Sydorchuk R., Sydorchuk L., Lostoridis E., Buia A., McFarlane M., Ciani R., Munoz-Cruzado V.M.D., Tartaglia D., Ioannidis O., Muhrbeck M., Reicher M., Roscio F., Ceresoli M., Tsiftsis D., Kavalakat A., Pintar T., Georgiou G., Ricci G., Mohan R., Saar S., Di Carlo I., Isik A., Ahmed A.Y.Y.M., Gonsaga R.A.T., Sammartano F., Tallon-Aguilar L., Shoko T., Hsu J., Kobe Y., Romeo C.G.L., Podda M., Mingoli A., Delgado R.C., Ekwen G., Aude V., Olona C., Boati P., Magnone S., Capaldi M., Bala M., Picetti E., Negoi I., Kok K.Y.Y., Jusoh A.C., Amato B., Nita G.E., de Beaux A., Demetrashvili Z., Davies R.J., Kim J.I., Pereira A., Fattori L., Paolillo C., Ghannam W., Rodriguez F.M., Berardi L., Florio M.G., Hecker M., Dubuisson V., O'Connor D.B., De'Angelis N., Dobric I., Massalou D., Ortenwall P., Pikoulis E., Ugarte-Sierra B., Zuidema W.P., Kechagias A., Marwah S., Litvin A., Nikolopoulos I., Pesce A., Uranues S., Luppi D., Flohe S., Martinez-Perez A., Lorenzo M., Vergano L.B., Manca M., Malacarne P., Kurihara H., Widder S., Pucciarelli M., Monzani F., Brambillasca P., Corbella D., Agresta F., Moore L., Buonomo L.A., Adeleye A.O., Kim D., Veroux M., Hardcastle T.C., Di Saverio S., Recordare A., Rubio-Perez I., Shlyapnikov S., Rahim R., Vega G.M.M., Boris K., Sawyer R., Baraket O., Soreide K., Weber C., Seak C.-J., Herman S., Gamberini E., Costa S., Mazzocconi G., Lozada E., Manatakis D., Lohsiriwat V., Ahmed A., Elbery B., Tiberio G.A.M., Santini M., Mellace L., Enoksen C.H., Major P., Parini D., Improta M., Fugazzola P., Pini S., Liberti G., Martino C., Cobianchi L., Canzi G., Cicuttin E., Kenig J., Zago M., Giannessi S., Scaglione M., Orsitto E., Cioni R., Ghiadoni L., Menichetti F., Agnoletti V., Sganga G., Prosperi P., Roviello F., De Paolis P., Gordini G., Forfori F., Ruscelli P., Gabrielli F., Puglisi A., Bertolucci A., Marchi S., Bellini M., Casagli S., De Simone B., Carmassi F., Marchetti S., Accorsini M., Cremonini C., Morelli F., Romeo L., Coccolini, F, Kluger, Y, Moore, E, Maier, R, Coimbra, R, Ordonez, C, Ivatury, R, Kirkpatrick, A, Biffl, W, Sartelli, M, Hecker, A, Ansaloni, L, Leppaniemi, A, Reva, V, Civil, I, Vega, F, Chiarugi, M, Chichom-Mefire, A, Sakakushev, B, Peitzman, A, Chiara, O, Abu-Zidan, F, Maegele, M, Miccoli, M, Chirica, M, Khokha, V, Sugrue, M, Fraga, G, Otomo, Y, Baiocchi, G, Catena, F, Kuliesius, Z, Conti, L, Dogjani, A, Lee, J, Consani, H, Russello, D, Bortul, M, Maurel, T, Kaf, H, Adamou, H, Alin, V, Robustelli, U, Sato, N, Seretis, C, Quiodettis, M, Gomes, C, Kong, V, Zakaria, A, Guner, A, Gachabayov, M, Chowdhury, S, Pata, F, Garcia, A, Rems, M, Das, K, Riedel, J, Lasithiotakis, K, Sydorchuk, R, Sydorchuk, L, Lostoridis, E, Buia, A, Mcfarlane, M, Ciani, R, Munoz-Cruzado, V, Tartaglia, D, Ioannidis, O, Muhrbeck, M, Reicher, M, Roscio, F, Ceresoli, M, Tsiftsis, D, Kavalakat, A, Pintar, T, Georgiou, G, Ricci, G, Mohan, R, Saar, S, Di Carlo, I, Isik, A, Ahmed, A, Gonsaga, R, Sammartano, F, Tallon-Aguilar, L, Shoko, T, Hsu, J, Kobe, Y, Romeo, C, Podda, M, Mingoli, A, Delgado, R, Ekwen, G, Aude, V, Olona, C, Boati, P, Magnone, S, Capaldi, M, Bala, M, Picetti, E, Negoi, I, Kok, K, Jusoh, A, Amato, B, Nita, G, de Beaux, A, Demetrashvili, Z, Davies, R, Kim, J, Pereira, A, Fattori, L, Paolillo, C, Ghannam, W, Rodriguez, F, Berardi, L, Florio, M, Hecker, M, Dubuisson, V, O'Connor, D, De'Angelis, N, Dobric, I, Massalou, D, Ortenwall, P, Pikoulis, E, Ugarte-Sierra, B, Zuidema, W, Kechagias, A, Marwah, S, Litvin, A, Nikolopoulos, I, Pesce, A, Uranues, S, Luppi, D, Flohe, S, Martinez-Perez, A, Lorenzo, M, Vergano, L, Manca, M, Malacarne, P, Kurihara, H, Widder, S, Pucciarelli, M, Monzani, F, Brambillasca, P, Corbella, D, Agresta, F, Moore, L, Buonomo, L, Adeleye, A, Kim, D, Veroux, M, Hardcastle, T, Di Saverio, S, Recordare, A, Rubio-Perez, I, Shlyapnikov, S, Rahim, R, Vega, G, Boris, K, Sawyer, R, Baraket, O, Soreide, K, Weber, C, Seak, C, Herman, S, Gamberini, E, Costa, S, Mazzocconi, G, Lozada, E, Manatakis, D, Lohsiriwat, V, Elbery, B, Tiberio, G, Santini, M, Mellace, L, Enoksen, C, Major, P, Parini, D, Improta, M, Fugazzola, P, Pini, S, Liberti, G, Martino, C, Cobianchi, L, Canzi, G, Cicuttin, E, Kenig, J, Zago, M, Giannessi, S, Scaglione, M, Orsitto, E, Cioni, R, Ghiadoni, L, Menichetti, F, Agnoletti, V, Sganga, G, Prosperi, P, Roviello, F, De Paolis, P, Gordini, G, Forfori, F, Ruscelli, P, Gabrielli, F, Puglisi, A, Bertolucci, A, Marchi, S, Bellini, M, Casagli, S, De Simone, B, Carmassi, F, Marchetti, S, Accorsini, M, Cremonini, C, Morelli, F, Romeo, L, and HUS Abdominal Center

Subjects
System, Consensus, Internationality, Delphi Technique, Accrual, Process (engineering), media_common.quotation_subject, Performance, education, lcsh:Surgery, 030230 surgery, Analysis, Data, Morbidity, Mortality, Outcome, Planning, Product, World, 03 medical and health sciences, 0302 clinical medicine, Trauma management, Health care, Medicine, Humans, Operations management, Quality (business), Product (category theory), media_common, Quality Indicators, Health Care, Core set, business.industry, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Analysi, lcsh:RD1-811, lcsh:RC86-88.9, CARE, 3126 Surgery, anesthesiology, intensive care, radiology, Core (game theory), Traumatology, Emergency Medicine, Surgery, business, Research Article
Abstract

Introduction Quality in medical care must be measured in order to be improved. Trauma management is part of health care, and by definition, it must be checked constantly. The only way to measure quality and outcomes is to systematically accrue data and analyze them. Material and methods A systematic revision of the literature about quality indicators in trauma associated to an international consensus conference Results An internationally approved base core set of 82 trauma quality indicators was obtained: Indicators were divided into 6 fields: prevention, structure, process, outcome, post-traumatic management, and society integrational effects. Conclusion Present trauma quality indicator core set represents the result of an international effort aiming to provide a useful tool in quality evaluation and improvement. Further improvement may only be possible through international trauma registry development. This will allow for huge international data accrual permitting to evaluate results and compare outcomes.

Published
2021

26. Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration:a MACUSTAR study report

Author

Saßmannshausen, Marlene, Behning, Charlotte, Isselmann, Ben, Schmid, Matthias, Finger, Robert P., Holz, F. G., Schmitz-Valckenberg, Steffen, Pfau, Maximilian, Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P. G., Behning, C., Belmouhand, M., Berger, M., Binns, A., Boon, C. J.F., Böttger, M., Bouchet, C., Brazier, J. E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D. P., Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Finger, R. P., Fletcher, E., Floyd, H., Francisco, C., Gutfleisch, M., Hogg, R., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Leal, S., Lechanteur, Y. T.E., Luhmann, U. F.O., Lüning, A., and Marques, I.

Abstract

Quantification of the relative ellipsoid zone reflectivity (rEZR) might be a structural surrogate parameter for an early disease progression in the context of age-related macular degeneration (AMD). Within the European multicenter, cross-sectional MACUSTAR study, we have devised an automatic approach to determine the mean rEZR [arbitrary units, AU] at two independent visits in SD-OCT volume scans in study participants. Linear mixed-effects models were applied to analyze the association of AMD stage and AMD associated high-risk features including presence of pigmentary abnormalities, reticular pseudodrusen (RPD), volume of the retinal-pigment-epithelial–drusenoid-complex (RPEDC) with the rEZR. Intra-class correlation coefficients (ICC) were determined for rEZR reliability analysis. Within the overall study cohort (301 participants), we could observe decreased rEZR values (coefficient estimate ± standard error) of − 8.05 ± 2.44 AU (p = 0.0011) in the intermediate and of − 22.35 ± 3.28 AU (p < 0.0001) in the late AMD group. RPD presence was significantly associated with the rEZR in iAMD eyes (− 6.49 ± 3.14 AU; p = 0.0403), while there was a good ICC of 0.846 (95% confidence interval: 0.809; 0.876) in the overall study cohort. This study showed an association of rEZR with increasing disease severity and the presence of iAMD high-risk features. Further studies are necessary to evaluate the rEZR’s value as a novel biomarker for AMD and disease progression.

Published
2022

30. Liver trauma: WSES 2020 guidelines

Author

Coccolini F., Coimbra R., Ordonez C., Kluger Y., Vega F., Moore E. E., Biffl W., Peitzman A., Horer T., Abu-Zidan F. M., Sartelli M., Fraga G. P., Cicuttin E., Ansaloni L., Parra M. W., Millan M., Deangelis N., Inaba K., Velmahos G., Maier R., Khokha V., Sakakushev B., Augustin G., Di Saverio S., Pikoulis E., Chirica M., Reva V., Leppaniemi A., Manchev V., Chiarugi M., Damaskos D., Weber D., Parry N., Demetrashvili Z., Civil I., Napolitano L., Corbella D., Catena F., Bahouth H., Tolonen M., Fugazzola P., Serna J. J., Rodriguez F., Garcia A. F., Gonzalez A., Pino L. F., Guzman-Rodriguez M., Pereira B. M., Kirkpatrick A., Mefire A. C., Tarasconi A., Chiara O., Gomes C. A., Galante J., Bala M., Perfetti P., MacHado F., Romeo O., Salvetti F., Ghiadoni L., Forfori F., Malacarne P., Pini S., Pucciarelli M., Ceresoli M., Arvieux C., Khokha D., Spain D. A., Isik A., Coccolini, F, Coimbra, R, Ordonez, C, Kluger, Y, Vega, F, Moore, E, Biffl, W, Peitzman, A, Horer, T, Abu-Zidan, F, Sartelli, M, Fraga, G, Cicuttin, E, Ansaloni, L, Parra, M, Millan, M, Deangelis, N, Inaba, K, Velmahos, G, Maier, R, Khokha, V, Sakakushev, B, Augustin, G, Di Saverio, S, Pikoulis, E, Chirica, M, Reva, V, Leppaniemi, A, Manchev, V, Chiarugi, M, Damaskos, D, Weber, D, Parry, N, Demetrashvili, Z, Civil, I, Napolitano, L, Corbella, D, Catena, F, Bahouth, H, Tolonen, M, Fugazzola, P, Serna, J, Rodriguez, F, Garcia, A, Gonzalez, A, Pino, L, Guzman-Rodriguez, M, Pereira, B, Kirkpatrick, A, Mefire, A, Tarasconi, A, Chiara, O, Gomes, C, Galante, J, Bala, M, Perfetti, P, Machado, F, Romeo, O, Salvetti, F, Ghiadoni, L, Forfori, F, Malacarne, P, Pini, S, Pucciarelli, M, Ceresoli, M, Arvieux, C, Khokha, D, Spain, D, Isik, A, and Apollo - University of Cambridge Repository

Subjects
Non-operative management, Abdominal Injuries, Review, 030230 surgery, Guideline, Liver disease, 0302 clinical medicine, Injury Severity Score, Trauma management, Abdominal Injuries / surgery, Medicine, Pediatric, Evidence-Based Medicine, Interventional, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Classification, Optimal management, 3. Good health, Liver, Emergency Medicine, Patient Care Management / methods, Radiology, Adult, medicine.medical_specialty, Guidelines, Hemorrhage, Intensive care, Liver trauma, Minor, Moderate, Operative management, Severe, Surgery, Hemodynamics / physiology, lcsh:Surgery, 03 medical and health sciences, Patient safety, Emergency surgery, Humans, Intensive care medicine, business.industry, Hemodynamics, 030208 emergency & critical care medicine, Evidence-based medicine, lcsh:RD1-811, lcsh:RC86-88.9, medicine.disease, Patient Care Management, Liver / injuries, business
Abstract

Liver injuries represent one of the most frequent life-threatening injuries in trauma patients. In determining the optimal management strategy, the anatomic injury, the hemodynamic status, and the associated injuries should be taken into consideration. Liver trauma approach may require non-operative or operative management with the intent to restore the homeostasis and the normal physiology. The management of liver trauma should be multidisciplinary including trauma surgeons, interventional radiologists, and emergency and ICU physicians. The aim of this paper is to present the World Society of Emergency Surgery (WSES) liver trauma management guidelines.

Published
2020

33. WSES-AAST guidelines: management of inflammatory bowel disease in the emergency setting

Author

De Simone, B. Davies, J. Chouillard, E. Di Saverio, S. Hoentjen, F. Tarasconi, A. Sartelli, M. Biffl, W.L. Ansaloni, L. Coccolini, F. Chiarugi, M. De’Angelis, N. Moore, E.E. Kluger, Y. Abu-Zidan, F. Sakakushev, B. Coimbra, R. Celentano, V. Wani, I. Pintar, T. Sganga, G. Di Carlo, I. Tartaglia, D. Pikoulis, M. Cardi, M. De Moya, M.A. Leppaniemi, A. Kirkpatrick, A. Agnoletti, V. Poggioli, G. Carcoforo, P. Baiocchi, G.L. Catena, F.

Abstract

Background: Despite the current therapeutic options for the treatment of inflammatory bowel disease, surgery is still frequently required in the emergency setting, although the number of cases performed seems to have decreased in recent years. The World Society of Emergency Surgery decided to debate in a consensus conference of experts, the main pertinent issues around the management of inflammatory bowel disease in the emergent situation, with the need to provide focused guidelines for acute care and emergency surgeons. Method: A group of experienced surgeons and gastroenterologists were nominated to develop the topics assigned and answer the questions addressed by the Steering Committee of the project. Each expert followed a precise analysis and grading of the studies selected for review. Statements and recommendations were discussed and voted at the Consensus Conference of the 6th World Society of Emergency Surgery held in Nijmegen (The Netherlands) in June 2019. Conclusions: Complicated inflammatory bowel disease requires a multidisciplinary approach because of the complexity of this patient group and disease spectrum in the emergency setting, with the aim of obtaining safe surgery with good functional outcomes and a decreasing stoma rate where appropriate. © 2021, The Author(s).

Published
2021

37. American Association for the Surgery of Trauma-World Society of Emergency Surgery guidelines on diagnosis and management of peripheral vascular injuries

Author

Kobayashi, L. Coimbra, R. Goes, A.M.O. Reva, V. Santorelli, J. Moore, E.E. Galante, J. Abu-Zidan, F. Peitzman, A.B. Ordonez, C. Maier, R.V. Di Saverio, S. Ivatury, R. De Angelis, N. Scalea, T. Catena, F. Kirkpatrick, A. Khokha, V. Parry, N. Civil, I. Leppaniemi, A. Chirica, M. Pikoulis, E. Fraga, G.P. Chiarugi, M. Damaskos, D. Cicuttin, E. Ceresoli, M. De Simone, B. Vega-Rivera, F. Sartelli, M. Biffl, W. Ansaloni, L. Weber, D.G. Coccolini, F.

Abstract

The peripheral arteries and veins of the extremities are among the most commonly injured vessels in both civilian and military vascular trauma. Blunt causes are more frequent than penetrating except during military conflicts and in certain geographic areas. Physical examination and simple bedside investigations of pulse pressures are key in early identification of these injuries. In stable patients with equivocal physical examinations, computed tomography angiograms have become the mainstay of screening and diagnosis. Immediate open surgical repair remains the first-line therapy in most patients. However, advances in endovascular therapies and more widespread availability of this technology have resulted in an increase in the range of injuries and frequency of utilization of minimally invasive treatments for vascular injuries in stable patients. Prevention of and early detection and treatment of compartment syndrome remain essential in the recovery of patients with significant peripheral vascular injuries. The decision to perform amputation in patients with mangled extremities remains difficult with few clear indicators. The American Association for the Surgery of Trauma in conjunction with the World Society of Emergency Surgery seeks to summarize the literature to date and provide guidelines on the presentation, diagnosis, and treatment of peripheral vascular injuries. LEVEL OF EVIDENCE Review study, level IV. © Wolters Kluwer Health, Inc. All rights reserved.

Published
2020

38. American Association for the Surgery of Trauma-World Society of Emergency Surgery guidelines on diagnosis and management of abdominal vascular injuries

Author

Kobayashi, L. Coimbra, R. Goes, A.M.O. Reva, V. Santorelli, J. Moore, E.E. Galante, J.M. Abu-Zidan, F. Peitzman, A.B. Ordonez, C.A. Maier, R.V. Di Saverio, S. Ivatury, R. De Angelis, N. Scalea, T. Catena, F. Kirkpatrick, A. Khokha, V. Parry, N. Civil, I. Leppaniemi, A. Chirica, M. Pikoulis, E. Fraga, G.P. Chiarugi, M. Damaskos, D. Cicuttin, E. Ceresoli, M. De Simone, B. Vega-Rivera, F. Sartelli, M. Biffl, W. Ansaloni, L. Weber, D.G. Coccolini, F.

Abstract

Abdominal vascular trauma accounts for a small percentage of military and a moderate percentage of civilian trauma, affecting all age ranges and impacting young adult men most frequently. Penetrating causes are more frequent than blunt in adults, while blunt mechanisms are more common among pediatric populations. High rates of associated injuries, bleeding, and hemorrhagic shock ensure that, despite advances in both diagnostic and therapeutic technologies, immediate open surgical repair remains the mainstay of treatment for traumatic abdominal vascular injuries. Because of their devastating nature, abdominal vascular injuries remain a significant source of morbidity and mortality among trauma patients. The American Association for the Surgery of Trauma in conjunction with the World Society of Emergency Surgery seek to summarize the literature to date and provide guidelines on the presentation, diagnosis, and treatment of abdominal vascular injuries. LEVEL OF EVIDENCE Review study, level IV. © Wolters Kluwer Health, Inc. All rights reserved.

Published
2020

39. 2020 update of the WSES guidelines for the management of acute colonic diverticulitis in the emergency setting

Author

Sartelli, M. Weber, D.G. Kluger, Y. Ansaloni, L. Coccolini, F. Abu-Zidan, F. Augustin, G. Ben-Ishay, O. Biffl, W.L. Bouliaris, K. Catena, R. Ceresoli, M. Chiara, O. Chiarugi, M. Coimbra, R. Cortese, F. Cui, Y. Damaskos, D. De' Angelis, G.L. Delibegovic, S. Demetrashvili, Z. De Simone, B. Di Marzo, F. Di Saverio, S. Duane, T.M. Faro, M.P. Fraga, G.P. Gkiokas, G. Gomes, C.A. Hardcastle, T.C. Hecker, A. Karamarkovic, A. Kashuk, J. Khokha, V. Kirkpatrick, A.W. Kok, K.Y.Y. Inaba, K. Isik, A. Labricciosa, F.M. Latifi, R. Leppäniemi, A. Litvin, A. Mazuski, J.E. Maier, R.V. Marwah, S. McFarlane, M. Moore, E.E. Moore, F.A. Negoi, I. Pagani, L. Rasa, K. Rubio-Perez, I. Sakakushev, B. Sato, N. Sganga, G. Siquini, W. Tarasconi, A. Tolonen, M. Ulrych, J. Zachariah, S.K. Catena, F.

Abstract

Acute colonic diverticulitis is one of the most common clinical conditions encountered by surgeons in the acute setting. An international multidisciplinary panel of experts from the World Society of Emergency Surgery (WSES) updated its guidelines for management of acute left-sided colonic diverticulitis (ALCD) according to the most recent available literature. The update includes recent changes introduced in the management of ALCD. The new update has been further integrated with advances in acute right-sided colonic diverticulitis (ARCD) that is more common than ALCD in select regions of the world. © 2020 The Author(s).

Published
2020

40. COVID-19 the showdown for mass casualty preparedness and management: The Cassandra Syndrome

Author

Coccolini, F. Sartelli, M. Kluger, Y. Pikoulis, E. Karamagioli, E. Moore, E.E. Biffl, W.L. Peitzman, A. Hecker, A. Chirica, M. Damaskos, D. Ordonez, C. Vega, F. Fraga, G.P. Chiarugi, M. Di Saverio, S. Kirkpatrick, A.W. Abu-Zidan, F. Mefire, A.C. Leppaniemi, A. Khokha, V. Sakakushev, B. Catena, R. Coimbra, R. Ansaloni, L. Corbella, D. Catena, F.

Abstract

Since December 2019, the world is potentially facing one of the most difficult infectious situations of the last decades. COVID-19 epidemic warrants consideration as a mass casualty incident (MCI) of the highest nature. An optimal MCI/disaster management should consider all four phases of the so-called disaster cycle: mitigation, planning, response, and recovery. COVID-19 outbreak has demonstrated the worldwide unpreparedness to face a global MCI. This present paper thus represents a call for action to solicitate governments and the Global Community to actively start effective plans to promote and improve MCI management preparedness in general, and with an obvious current focus on COVID-19. © 2020 The Author(s).

Published
2020

41. Duodeno-pancreatic and extrahepatic biliary tree trauma: WSES-AAST guidelines

Author

Coccolini, F., Kobayashi, L., Kluger, Y., Moore, E. E., Ansaloni, L., Biffl, W., Leppaniemi, A., Augustin, G., Reva, V., Wani, I., Kirkpatrick, A., Abu-Zidan, F., Cicuttin, E., Fraga, G. P., Ordonez, C., Pikoulis, E., Sibilla, M. G., Maier, R., Matsumura, Y., Masiakos, P. T., Khokha, V., Mefire, A. C., Ivatury, R., Favi, F., Manchev, V., Sartelli, M., Machado, F., Matsumoto, J., Chiarugi, M., Arvieux, C., Catena, F., Coimbra, R., Ben-Ishay, O., Tolonen, M., Bertelli, R., Horer, T., Ferrada, P., Di Carlo, I., Pereira, B. M., Parini, D., Montori, G., De Simone, B., Chiara, O., Hecker, A., Deangelis, N., Gomes, C. A., Galante, J., Bala, M., Mylonas, K. S., Pikoulis, A., Perfetti, P., Chirica, M., Bado, J., Inaba, K., Parry, N., Romeo, O., Stommel, M., Rajashekar, M., Tan, E., Salvetti, F., and Sakakushev, B.

Subjects
Percutaneous, Biliary tree, Injury, Review, Abdominal Injuries, 0302 clinical medicine, Trauma Centers, Bile Ducts, Extrahepatic, Conservative, Ultrasonography, Pediatric, medicine.diagnostic_test, Bile duct, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Interventional radiology, Classification, Operative, 3. Good health, Ampulla, medicine.anatomical_structure, Emergency Medicine, 030211 gastroenterology & hepatology, Pancreatic injury, Pancreas, Pediatric trauma, Focused Assessment with Sonography for Trauma, Adult, medicine.medical_specialty, Duodenum, lcsh:Surgery, Peritonitis, Guidelines as Topic, Guidelines, Trauma, 03 medical and health sciences, Endoscopic retrograde cholangiopancreatography (ERCP), medicine, Non-operative, Humans, Endoscopy, Surgery, business.industry, General surgery, 030208 emergency & critical care medicine, lcsh:RD1-811, lcsh:RC86-88.9, medicine.disease, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], General Surgery, Triage, business, Tomography, X-Ray Computed
Abstract

Contains fulltext : 215782.pdf (Publisher’s version ) (Open Access) Duodeno-pancreatic and extrahepatic biliary tree injuries are rare in both adult and pediatric trauma patients, and due to their anatomical location, associated injuries are very common. Mortality is primarily related to associated injuries, but morbidity remains high even in isolated injuries. Optimal management of duodeno-bilio-pancreatic injuries is dictated primarily by hemodynamic stability, clinical presentation, and grade of injury. Endoscopic and percutaneous interventions have increased the ability to non-operatively manage these injuries. Late diagnosis and treatment are both associated to increased morbidity and mortality. Sequelae of late presentations of pancreatic injury and complications of severe pancreatic trauma are also increasingly addressed endoscopically and with interventional radiology procedures. However, for moderate and severe extrahepatic biliary and severe duodeno-pancreatic injuries, immediate operative intervention is preferred as associated injuries are frequent and commonly present with hemodynamic instability or peritonitis. The aim of this paper is to present the World Society of Emergency Surgery (WSES) and American Association for the Surgery of Trauma (AAST) duodenal, pancreatic, and extrahepatic biliary tree trauma management guidelines.

Published
2019

45. Ethical considerations in conducting surgical research in severe complicated intra-abdominal sepsis

Author

Doig, C. J., Page, S. A., Mckee, J. L., Moore, E. E., Abu-Zidan, F. M., Carroll, R., Marshall, J. C., Faris, P. D., Tolonen, M., Catena, F., Cocolini, F., Sartelli, M., Ansaloni, L., Minor, S. F., Peirera, B. M., Diaz, J. J., Kirkpatrick, A. W., Roberts, D. J., Leppaniemi, A., Jenne, C. N., Odobez, Chiara, Kubes, P., Manns, B., Kluger, Y., Fraga, G. P., Pereira, B. M., Sugrue, M., Holm, T., Ren, J., Ball, C. G., Coimbra, R., Balogh, Z. J., Dixon, E., Biffl, W., Maclean, A., Ball, I., Drover, J. W., Mcbeth, P. B., Posadas-Calleja, J. G., Parry, N. G., Di Saverio, S., Ordonez, C. A., Bendinelli, C., Macdonald, B., Dunham, M., Reso, A., Vogt, K. N., Blaser, A. R., Malbrain, M., Tartaglia, D., De Waele, J., Dubuisson, V., Lampela, H., Bodnar, Z., Isik, A., Picetti, E., Hameed, M., Garraway, N. R., Julien, L., Widder, S., Bradley, N. L., Engels, P. T., Leeper, W. R., Beckett, A., Supporting clinical sciences, and Intensive Care

Subjects
medicine.medical_specialty, Open-abdomen, lcsh:Surgery, Intra-peritoneal sepsis, multiple organ dysfunction, Review, 030230 surgery, 03 medical and health sciences, 0302 clinical medicine, Sepsis, Humans, Medicine, Prospective Studies, Digestive System Surgical Procedures, Medicine(all), Surgical research, Informed Consent, business.industry, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Correction, lcsh:RD1-811, lcsh:RC86-88.9, WAIVER, 3. Good health, Intra abdominal sepsis, Surgery, Research Design, Randomized Controlled Trial, Emergency Medicine, Consent, Multiple organ dysfunction, Randomized controlled trial, Waiver, consent, business
Abstract

Background Severe complicated intra-abdominal sepsis (SCIAS) has high mortality, thought due in part to progressive bio-mediator generation, systemic inflammation, and multiple organ failure. Treatment includes early antibiotics and operative source control. At surgery, open abdomen management with negative-peritoneal-pressure therapy (NPPT) has been hypothesized to mitigate MOF and death, although clinical equipoise for this operative approach exists. The Closed or Open after Laparotomy (COOL) study (https://clinicaltrials.gov/ct2/show/NCT03163095) will prospectively randomize eligible patients intra-operatively to formal abdominal closure or OA with NPTT. We review the ethical basis for conducting research in SCIAS. Main body Research in critically ill incapacitated patients is important to advance care. Conducting research among SCIAS is complicated due to the severity of illness including delirium, need for emergent interventions, diagnostic criteria confirmed only at laparotomy, and obtundation from anaesthesia. In other circumstances involving critically ill patients, clinical experts have worked closely with ethicists to apply principles that balance the rights of patients whilst simultaneously permitting inclusion in research. In Canada, the Tri-Council Policy Statement-2 (TCPS-2) describes six criteria that permit study enrollment and randomization in such situations: (a) serious threat to the prospective participant requires immediate intervention; (b) either no standard efficacious care exists or the research offers realistic possibility of direct benefit; (c) risks are not greater than that involved in standard care or are clearly justified by prospect for direct benefits; (d) prospective participant is unconscious or lacks capacity to understand the complexities of the research; (e) third-party authorization cannot be secured in sufficient time; and (f) no relevant prior directives are known to exist that preclude participation. TCPS-2 criteria are in principle not dissimilar to other (inter)national criteria. The COOL study will use waiver of consent to initiate enrollment and randomization, followed by surrogate or proxy consent, and finally delayed informed consent in subjects that survive and regain capacity. Conclusions A delayed consent mechanism is a practical and ethical solution to challenges in research in SCIAS. The ultimate goal of consent is to balance respect for patient participants and to permit participation in new trials with a reasonable opportunity for improved outcome and minimal risk of harm.

Published
2019

46. 2019 update of the WSES guidelines for management of Clostridioides (Clostridium) difficile infection in surgical patients 11 Medical and Health Sciences 1103 Clinical Sciences

Author

Sartelli, M., Di Bella, Astrid, Mcfarland, L. V., Khanna, S., Furuya-Kanamori, L., Abuzeid, N., Abu-Zidan, F. M., Ansaloni, L., Augustin, G., Zimbalatti, Maria Antonietta, Ben-Ishay, O., Biffl, W. L., Brecher, S. M., Camacho-Ortiz, A., Cainzos, M. A., Chan, S., Cherry-Bukowiec, J. R., Clanton, J., Coccolini, F., Cocuz, M. E., Coimbra, R., Cortese, Francesco, Cui, Y., Czepiel, J., Demetrashvili, Z., Di Carlo, I., Di Saverio, S., Dumitru, I. M., Eckmann, C., Eiland, E. H., Forrester, J. D., Fraga, G. P., Frossard, J. L., Fry, D. E., Galeiras, R., Ghnnam, W., Gomes, C. A., Griffiths, E. A., Guirao, X., Ahmed, M. H., Herzog, T., Kim, J. I., Iqbal, T., Isik, A., Itani, K. M. F., Labricciosa, F. M., Lee, Y. Y., Juang, P., Karamarkovic, A., Kim, P. K., Kluger, Y., Leppaniemi, A., Lohsiriwat, V., Machain, G. M., Marwah, S., Mazuski, J. E., Metan, G., Moore, E. E., Moore, F. A., Ordonez, C. A., Pagani, L., Petrosillo, Nicola, Portela, F., Rasa, K., Rems, M., Sakakushev, B. E., Segovia-Lohse, H., Sganga, Gabriele, Shelat, V. G., Spigaglia, P., Tattevin, P., Trana, C., Urbanek, L., Ulrych, J., Viale, P., Baiocchi, G. L., and Catena, F.

Subjects
Enterocolitis, Pseudomembranous, Incidence, Settore MED/18 - CHIRURGIA GENERALE, Antimicrobial treatment, Guidelines as Topic, Infection control, Clostridium difficile, Antimicrobial stewardship, Clostridioides difficile infection, Clostridium difficile infection, Fecal microbiota transplantation, Pseudomembranous colitis, Surgery, Emergency Medicine, Anti-Bacterial Agents, Postoperative Complications, Risk Factors, Antimicrobial Stewardship, Clostridium Infections, Enterocolitis, Pseudomembranous, Fecal Microbiota Transplantation, Humans, Infection Control
Published
2019

47. Duodeno-pancreatic and extrahepatic biliary tree trauma: WSES-AAST guidelines

Author

Coccolini, F. Kobayashi, L. Kluger, Y. Moore, E.E. Ansaloni, L. Biffl, W. Leppaniemi, A. Augustin, G. Reva, V. Wani, I. Kirkpatrick, A. Abu-Zidan, F. Cicuttin, E. Fraga, G.P. Ordonez, C. Pikoulis, E. Sibilla, M.G. Maier, R. Matsumura, Y. Masiakos, P.T. Khokha, V. Mefire, A.C. Ivatury, R. Favi, F. Manchev, V. Sartelli, M. Machado, F. Matsumoto, J. Chiarugi, M. Arvieux, C. Catena, F. Coimbra, R. Ben-Ishay, O. Tolonen, M. Bertelli, R. Horer, T. Ferrada, P. Di Carlo, I. Pereira, B.M. Parini, D. Montori, G. De Simone, B. Chiara, O. Hecker, A. Deangelis, N. Gomes, C.A. Galante, J. Bala, M. Mylonas, K.S. Pikoulis, A. Perfetti, P. Chirica, M. Bado, J. Inaba, K. Parry, N. Romeo, O. Stommel, M. Rajashekar, M. Tan, E. Salvetti, F. Sakakushev, B.

Abstract

Duodeno-pancreatic and extrahepatic biliary tree injuries are rare in both adult and pediatric trauma patients, and due to their anatomical location, associated injuries are very common. Mortality is primarily related to associated injuries, but morbidity remains high even in isolated injuries. Optimal management of duodeno-bilio-pancreatic injuries is dictated primarily by hemodynamic stability, clinical presentation, and grade of injury. Endoscopic and percutaneous interventions have increased the ability to non-operatively manage these injuries. Late diagnosis and treatment are both associated to increased morbidity and mortality. Sequelae of late presentations of pancreatic injury and complications of severe pancreatic trauma are also increasingly addressed endoscopically and with interventional radiology procedures. However, for moderate and severe extrahepatic biliary and severe duodeno-pancreatic injuries, immediate operative intervention is preferred as associated injuries are frequent and commonly present with hemodynamic instability or peritonitis. The aim of this paper is to present the World Society of Emergency Surgery (WSES) and American Association for the Surgery of Trauma (AAST) duodenal, pancreatic, and extrahepatic biliary tree trauma management guidelines. © 2019 The Author(s).

Published
2019

50. Erratum: Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA). [World J Emerg Surg. 11, (2016) (33)] DOI: 10.1186/s13017-016-0089-y

Author

Sartelli, M., Weber, D. G., Ruppé, E., Bassetti, M., Wright, B. J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F. M., Coimbra, R., Moore, E. E., Moore, F. A., Maier, R. V., De Waele, J. J., Kirkpatrick, A. W., Griffiths, E. A., Eckmann, C., Brink, A. J., Mazuski, J. E., May, A. K., Sawyer, R. G., Mertz, D., Montravers, P., Kumar, A., Roberts, J. A., Vincent, J. L., Watkins, R. R., Lowman, W., Spellberg, B., Abbott, I. J., Adesunkanmi, A. K., Al-Dahir, S., Al-Hasan, M. N., Agresta, F., Althani, A. A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z. J., Baraket, O., Bhangu, A., Beltrán, M. A., Bernhard, M., Biffl, W. L., Boermeester, M. A., Brecher, S. M., Cherry-Bukowiec, J. R., Buyne, O. R., Cainzos, M. A., Cairns, K. A., Camacho-Ortiz, A., Chandy, S. J., Che Jusoh, A., Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., De Simone, B., Dhingra, S., Diaz, J. J., Di Carlo, I., Dillip, A., Di Saverio, S., Doyle, M. P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S. R., Enani, M. A., Egiev, V. N., Elmangory, M. M., Ferrada, P., Fitchett, J. R., Fraga, G. P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S. R., Gomes, C. A., Gomi, H., Guzmán-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W. R., Herzog, T., Hodonou, A. M., Hong, S. K., Kafka-Ritsch, R., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kees, M. G., Kenig, J., Kiguba, R., Kim, P. K., Kluger, Y., Khokha, V., Koike, K., Kok, K. Y., Kong, V., Knox, M. C., Inaba, K., Isik, A., Iskandar, K., Ivatury, R. R., Labbate, M., Labricciosa, F. M., Laterre, P. F., Latifi, R., Lee, J. G., Lee, Y. R., Leone, M., Leppaniemi, A., Li, Y., Liang, S. Y., Loho, T., Maegele, M., Malama, S., Marei, H. E., Martin-Loeches, I., Marwah, S., Massele, A., Mcfarlane, M., Melo, R. B., Negoi, I., Nicolau, D. P., Nord, C. E., Ofori-Asenso, R., Omari, A. H., Ordonez, C. A., Ouadii, M., Pereira Júnior, G. A., Piazza, D., Pupelis, G., Rawson, T. M., Rems, M., Rizoli, S., Rocha, C., Sakakushev, B., Sanchez-Garcia, M., Sato, N., Segovia Lohse, H. A., Sganga, G., Siribumrungwong, B., Shelat, V. G., Soreide, K., Soto, R., Talving, P., Tilsed, J. V., Timsit, J. F., Trueba, G., Trung, N. T., Ulrych, J., van Goor, H., Vereczkei, A., Vohra, R. S., Wani, I., Uhl, W., Xiao, Y., Yuan, K. C., Zachariah, S. K., Zahar, J. R., Zakrison, T. L., Corcione, A., Melotti, R. M., Viscoli, C., Viale, P., Sartelli, M., Weber, D. G., Ruppé, E., Bassetti, M., Wright, B. J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F. M., Coimbra, R., Moore, E. E., Moore, F. A., Maier, R. V., De Waele, J. J., Kirkpatrick, A. W., Griffiths, E. A., Eckmann, C., Brink, A. J., Mazuski, J. E., May, A. K., Sawyer, R. G., Mertz, D., Montravers, P., Kumar, A., Roberts, J. A., Vincent, J. L., Watkins, R. R., Lowman, W., Spellberg, B., Abbott, I. J., Adesunkanmi, A. K., Al-Dahir, S., Al-Hasan, M. N., Agresta, F., Althani, A. A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z. J., Baraket, O., Bhangu, A., Beltrán, M. A., Bernhard, M., Biffl, W. L., Boermeester, M. A., Brecher, S. M., Cherry-Bukowiec, J. R., Buyne, O. R., Cainzos, M. A., Cairns, K. A., Camacho-Ortiz, A., Chandy, S. J., Che Jusoh, A., Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., De Simone, B., Dhingra, S., Diaz, J. J., Di Carlo, I., Dillip, A., Di Saverio, S., Doyle, M. P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S. R., Enani, M. A., Egiev, V. N., Elmangory, M. M., Ferrada, P., Fitchett, J. R., Fraga, G. P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S. R., Gomes, C. A., Gomi, H., Guzmán-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W. R., Herzog, T., Hodonou, A. M., Hong, S. K., Kafka-Ritsch, R., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kees, M. G., Kenig, J., Kiguba, R., Kim, P. K., Kluger, Y., Khokha, V., Koike, K., Kok, K. Y., Kong, V., Knox, M. C., Inaba, K., Isik, A., Iskandar, K., Ivatury, R. R., Labbate, M., Labricciosa, F. M., Laterre, P. F., Latifi, R., Lee, J. G., Lee, Y. R., Leone, M., Leppaniemi, A., Li, Y., Liang, S. Y., Loho, T., Maegele, M., Malama, S., Marei, H. E., Martin-Loeches, I., Marwah, S., Massele, A., Mcfarlane, M., Melo, R. B., Negoi, I., Nicolau, D. P., Nord, C. E., Ofori-Asenso, R., Omari, A. H., Ordonez, C. A., Ouadii, M., Pereira Júnior, G. A., Piazza, D., Pupelis, G., Rawson, T. M., Rems, M., Rizoli, S., Rocha, C., Sakakushev, B., Sanchez-Garcia, M., Sato, N., Segovia Lohse, H. A., Sganga, G., Siribumrungwong, B., Shelat, V. G., Soreide, K., Soto, R., Talving, P., Tilsed, J. V., Timsit, J. F., Trueba, G., Trung, N. T., Ulrych, J., van Goor, H., Vereczkei, A., Vohra, R. S., Wani, I., Uhl, W., Xiao, Y., Yuan, K. C., Zachariah, S. K., Zahar, J. R., Zakrison, T. L., Corcione, A., Melotti, R. M., Viscoli, C., and Viale, P.

Subjects
Settore MED/18 - CHIRURGIA GENERALE, Surgery, Emergency Medicine
Published
2017

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