1. The expression of sICAM-1 influenced by Clonorchis sinensis co-infection in CHB patients.
- Author
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Qiu J, Shang M, Li W, Zhang H, Liao Y, and Dong H
- Subjects
- Humans, Animals, Male, Adult, Female, Middle Aged, Liver parasitology, Biomarkers blood, Aspartate Aminotransferases blood, Young Adult, Intercellular Adhesion Molecule-1 blood, Coinfection parasitology, Clonorchiasis blood, Clonorchis sinensis, Hepatitis B, Chronic complications
- Abstract
Soluble Intercellular Adhesion Molecule-1 (sICAM-1) has emerged as an inflammatory biomarker of many essential functions. We investigated the level of sICAM-1 influenced by Clonorchis sinensis ( C. sinensis ) co-infection in chronic hepatitis B (CHB) patients to explore the degree of liver tissue inflammation and liver function damage after co-infection. The study included data from patients with C. sinensis mono-infection (n=27), hepatitis B virus (HBV) mono-infection (n=32), C. sinensis and HBV co-infection (n=24), post-hepatitis B liver cirrhosis (n=18), post-hepatitis B liver cirrhosis co-infected with C. sinensis (n=16), and healthy controls (n=39). The level of sICAM-1 was measured with specific enzyme-linked immunosorbent assay method. Compared to the healthy control group, all the experimental groups had significantly higher serum sICAM-1 levels. The levels of sICAM-1 in co-infected groups were significantly higher compared to the mono-infection groups and were positively correlated with the levels of glutamate aminotransferase (ALT) and aspartate aminotransferase (AST). Our research findings confirmed that co-infection could exacerbate liver tissue inflammation and liver function damage in patients, could raise the sICAM-1 level, and may lead to the chronicity of HBV infection. These results provide clues for pathological mechanism study and formulating treatment plans.
- Published
- 2024
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