Search

Your search keyword '"Coker, Elizabeth A."' showing total 216 results
Start Over Author "Coker, Elizabeth A."
216 results on '"Coker, Elizabeth A."'

3. AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors

Author

Dunn, Shanade, Eberlein, Cath, Yu, Jason, Gris-Oliver, Albert, Ong, Swee Hoe, Yelland, Urs, Cureton, Natalie, Staniszewska, Anna, McEwen, Robert, Fox, Millie, Pilling, James, Hopcroft, Philip, Coker, Elizabeth A., Jaaks, Patricia, Garnett, Mathew J., Isherwood, Beverley, Serra, Violeta, Davies, Barry R., Barry, Simon T., Lynch, James T., and Yusa, Kosuke

Published
2022
Full Text
View/download PDF

4. Table S4 from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

Author

Bashi, Azadeh C., primary, Coker, Elizabeth A., primary, Bulusu, Krishna C., primary, Jaaks, Patricia, primary, Crafter, Claire, primary, Lightfoot, Howard, primary, Milo, Marta, primary, McCarten, Katrina, primary, Jenkins, David F., primary, van der Meer, Dieudonne, primary, Lynch, James T., primary, Barthorpe, Syd, primary, Andersen, Courtney L., primary, Barry, Simon T., primary, Beck, Alexandra, primary, Cidado, Justin, primary, Gordon, Jacob A., primary, Hall, Caitlin, primary, Hall, James, primary, Mali, Iman, primary, Mironenko, Tatiana, primary, Mongeon, Kevin, primary, Morris, James, primary, Richardson, Laura, primary, Smith, Paul D., primary, Tavana, Omid, primary, Tolley, Charlotte, primary, Thomas, Frances, primary, Willis, Brandon S., primary, Yang, Wanjuan, primary, O'Connor, Mark J., primary, McDermott, Ultan, primary, Critchlow, Susan E., primary, Drew, Lisa, primary, Fawell, Stephen E., primary, Mettetal, Jerome T., primary, and Garnett, Mathew J., primary

Published
2024
Full Text
View/download PDF

5. Figure 6 from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

Author

Bashi, Azadeh C., primary, Coker, Elizabeth A., primary, Bulusu, Krishna C., primary, Jaaks, Patricia, primary, Crafter, Claire, primary, Lightfoot, Howard, primary, Milo, Marta, primary, McCarten, Katrina, primary, Jenkins, David F., primary, van der Meer, Dieudonne, primary, Lynch, James T., primary, Barthorpe, Syd, primary, Andersen, Courtney L., primary, Barry, Simon T., primary, Beck, Alexandra, primary, Cidado, Justin, primary, Gordon, Jacob A., primary, Hall, Caitlin, primary, Hall, James, primary, Mali, Iman, primary, Mironenko, Tatiana, primary, Mongeon, Kevin, primary, Morris, James, primary, Richardson, Laura, primary, Smith, Paul D., primary, Tavana, Omid, primary, Tolley, Charlotte, primary, Thomas, Frances, primary, Willis, Brandon S., primary, Yang, Wanjuan, primary, O'Connor, Mark J., primary, McDermott, Ultan, primary, Critchlow, Susan E., primary, Drew, Lisa, primary, Fawell, Stephen E., primary, Mettetal, Jerome T., primary, and Garnett, Mathew J., primary

Published
2024
Full Text
View/download PDF

6. Supplementary Figures S1-S16 from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

Author

Bashi, Azadeh C., primary, Coker, Elizabeth A., primary, Bulusu, Krishna C., primary, Jaaks, Patricia, primary, Crafter, Claire, primary, Lightfoot, Howard, primary, Milo, Marta, primary, McCarten, Katrina, primary, Jenkins, David F., primary, van der Meer, Dieudonne, primary, Lynch, James T., primary, Barthorpe, Syd, primary, Andersen, Courtney L., primary, Barry, Simon T., primary, Beck, Alexandra, primary, Cidado, Justin, primary, Gordon, Jacob A., primary, Hall, Caitlin, primary, Hall, James, primary, Mali, Iman, primary, Mironenko, Tatiana, primary, Mongeon, Kevin, primary, Morris, James, primary, Richardson, Laura, primary, Smith, Paul D., primary, Tavana, Omid, primary, Tolley, Charlotte, primary, Thomas, Frances, primary, Willis, Brandon S., primary, Yang, Wanjuan, primary, O'Connor, Mark J., primary, McDermott, Ultan, primary, Critchlow, Susan E., primary, Drew, Lisa, primary, Fawell, Stephen E., primary, Mettetal, Jerome T., primary, and Garnett, Mathew J., primary

Published
2024
Full Text
View/download PDF

7. Figure 5 from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

Author

Bashi, Azadeh C., primary, Coker, Elizabeth A., primary, Bulusu, Krishna C., primary, Jaaks, Patricia, primary, Crafter, Claire, primary, Lightfoot, Howard, primary, Milo, Marta, primary, McCarten, Katrina, primary, Jenkins, David F., primary, van der Meer, Dieudonne, primary, Lynch, James T., primary, Barthorpe, Syd, primary, Andersen, Courtney L., primary, Barry, Simon T., primary, Beck, Alexandra, primary, Cidado, Justin, primary, Gordon, Jacob A., primary, Hall, Caitlin, primary, Hall, James, primary, Mali, Iman, primary, Mironenko, Tatiana, primary, Mongeon, Kevin, primary, Morris, James, primary, Richardson, Laura, primary, Smith, Paul D., primary, Tavana, Omid, primary, Tolley, Charlotte, primary, Thomas, Frances, primary, Willis, Brandon S., primary, Yang, Wanjuan, primary, O'Connor, Mark J., primary, McDermott, Ultan, primary, Critchlow, Susan E., primary, Drew, Lisa, primary, Fawell, Stephen E., primary, Mettetal, Jerome T., primary, and Garnett, Mathew J., primary

Published
2024
Full Text
View/download PDF

8. Figure 3 from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

Author

Bashi, Azadeh C., primary, Coker, Elizabeth A., primary, Bulusu, Krishna C., primary, Jaaks, Patricia, primary, Crafter, Claire, primary, Lightfoot, Howard, primary, Milo, Marta, primary, McCarten, Katrina, primary, Jenkins, David F., primary, van der Meer, Dieudonne, primary, Lynch, James T., primary, Barthorpe, Syd, primary, Andersen, Courtney L., primary, Barry, Simon T., primary, Beck, Alexandra, primary, Cidado, Justin, primary, Gordon, Jacob A., primary, Hall, Caitlin, primary, Hall, James, primary, Mali, Iman, primary, Mironenko, Tatiana, primary, Mongeon, Kevin, primary, Morris, James, primary, Richardson, Laura, primary, Smith, Paul D., primary, Tavana, Omid, primary, Tolley, Charlotte, primary, Thomas, Frances, primary, Willis, Brandon S., primary, Yang, Wanjuan, primary, O'Connor, Mark J., primary, McDermott, Ultan, primary, Critchlow, Susan E., primary, Drew, Lisa, primary, Fawell, Stephen E., primary, Mettetal, Jerome T., primary, and Garnett, Mathew J., primary

Published
2024
Full Text
View/download PDF

9. Figure 1 from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

Author

Bashi, Azadeh C., primary, Coker, Elizabeth A., primary, Bulusu, Krishna C., primary, Jaaks, Patricia, primary, Crafter, Claire, primary, Lightfoot, Howard, primary, Milo, Marta, primary, McCarten, Katrina, primary, Jenkins, David F., primary, van der Meer, Dieudonne, primary, Lynch, James T., primary, Barthorpe, Syd, primary, Andersen, Courtney L., primary, Barry, Simon T., primary, Beck, Alexandra, primary, Cidado, Justin, primary, Gordon, Jacob A., primary, Hall, Caitlin, primary, Hall, James, primary, Mali, Iman, primary, Mironenko, Tatiana, primary, Mongeon, Kevin, primary, Morris, James, primary, Richardson, Laura, primary, Smith, Paul D., primary, Tavana, Omid, primary, Tolley, Charlotte, primary, Thomas, Frances, primary, Willis, Brandon S., primary, Yang, Wanjuan, primary, O'Connor, Mark J., primary, McDermott, Ultan, primary, Critchlow, Susan E., primary, Drew, Lisa, primary, Fawell, Stephen E., primary, Mettetal, Jerome T., primary, and Garnett, Mathew J., primary

Published
2024
Full Text
View/download PDF

10. Supplementary Tables from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

Author

Bashi, Azadeh C., primary, Coker, Elizabeth A., primary, Bulusu, Krishna C., primary, Jaaks, Patricia, primary, Crafter, Claire, primary, Lightfoot, Howard, primary, Milo, Marta, primary, McCarten, Katrina, primary, Jenkins, David F., primary, van der Meer, Dieudonne, primary, Lynch, James T., primary, Barthorpe, Syd, primary, Andersen, Courtney L., primary, Barry, Simon T., primary, Beck, Alexandra, primary, Cidado, Justin, primary, Gordon, Jacob A., primary, Hall, Caitlin, primary, Hall, James, primary, Mali, Iman, primary, Mironenko, Tatiana, primary, Mongeon, Kevin, primary, Morris, James, primary, Richardson, Laura, primary, Smith, Paul D., primary, Tavana, Omid, primary, Tolley, Charlotte, primary, Thomas, Frances, primary, Willis, Brandon S., primary, Yang, Wanjuan, primary, O'Connor, Mark J., primary, McDermott, Ultan, primary, Critchlow, Susan E., primary, Drew, Lisa, primary, Fawell, Stephen E., primary, Mettetal, Jerome T., primary, and Garnett, Mathew J., primary

Published
2024
Full Text
View/download PDF

11. Figure 4 from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

Author

Bashi, Azadeh C., primary, Coker, Elizabeth A., primary, Bulusu, Krishna C., primary, Jaaks, Patricia, primary, Crafter, Claire, primary, Lightfoot, Howard, primary, Milo, Marta, primary, McCarten, Katrina, primary, Jenkins, David F., primary, van der Meer, Dieudonne, primary, Lynch, James T., primary, Barthorpe, Syd, primary, Andersen, Courtney L., primary, Barry, Simon T., primary, Beck, Alexandra, primary, Cidado, Justin, primary, Gordon, Jacob A., primary, Hall, Caitlin, primary, Hall, James, primary, Mali, Iman, primary, Mironenko, Tatiana, primary, Mongeon, Kevin, primary, Morris, James, primary, Richardson, Laura, primary, Smith, Paul D., primary, Tavana, Omid, primary, Tolley, Charlotte, primary, Thomas, Frances, primary, Willis, Brandon S., primary, Yang, Wanjuan, primary, O'Connor, Mark J., primary, McDermott, Ultan, primary, Critchlow, Susan E., primary, Drew, Lisa, primary, Fawell, Stephen E., primary, Mettetal, Jerome T., primary, and Garnett, Mathew J., primary

Published
2024
Full Text
View/download PDF

12. Data from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

Author

Bashi, Azadeh C., primary, Coker, Elizabeth A., primary, Bulusu, Krishna C., primary, Jaaks, Patricia, primary, Crafter, Claire, primary, Lightfoot, Howard, primary, Milo, Marta, primary, McCarten, Katrina, primary, Jenkins, David F., primary, van der Meer, Dieudonne, primary, Lynch, James T., primary, Barthorpe, Syd, primary, Andersen, Courtney L., primary, Barry, Simon T., primary, Beck, Alexandra, primary, Cidado, Justin, primary, Gordon, Jacob A., primary, Hall, Caitlin, primary, Hall, James, primary, Mali, Iman, primary, Mironenko, Tatiana, primary, Mongeon, Kevin, primary, Morris, James, primary, Richardson, Laura, primary, Smith, Paul D., primary, Tavana, Omid, primary, Tolley, Charlotte, primary, Thomas, Frances, primary, Willis, Brandon S., primary, Yang, Wanjuan, primary, O'Connor, Mark J., primary, McDermott, Ultan, primary, Critchlow, Susan E., primary, Drew, Lisa, primary, Fawell, Stephen E., primary, Mettetal, Jerome T., primary, and Garnett, Mathew J., primary

Published
2024
Full Text
View/download PDF

13. Figure 2 from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

Author

Bashi, Azadeh C., primary, Coker, Elizabeth A., primary, Bulusu, Krishna C., primary, Jaaks, Patricia, primary, Crafter, Claire, primary, Lightfoot, Howard, primary, Milo, Marta, primary, McCarten, Katrina, primary, Jenkins, David F., primary, van der Meer, Dieudonne, primary, Lynch, James T., primary, Barthorpe, Syd, primary, Andersen, Courtney L., primary, Barry, Simon T., primary, Beck, Alexandra, primary, Cidado, Justin, primary, Gordon, Jacob A., primary, Hall, Caitlin, primary, Hall, James, primary, Mali, Iman, primary, Mironenko, Tatiana, primary, Mongeon, Kevin, primary, Morris, James, primary, Richardson, Laura, primary, Smith, Paul D., primary, Tavana, Omid, primary, Tolley, Charlotte, primary, Thomas, Frances, primary, Willis, Brandon S., primary, Yang, Wanjuan, primary, O'Connor, Mark J., primary, McDermott, Ultan, primary, Critchlow, Susan E., primary, Drew, Lisa, primary, Fawell, Stephen E., primary, Mettetal, Jerome T., primary, and Garnett, Mathew J., primary

Published
2024
Full Text
View/download PDF

14. Effective drug combinations in breast, colon and pancreatic cancer cells

Author

Jaaks, Patricia, Coker, Elizabeth A., Vis, Daniel J., Edwards, Olivia, Carpenter, Emma F., Leto, Simonetta M., Dwane, Lisa, Sassi, Francesco, Lightfoot, Howard, Barthorpe, Syd, van der Meer, Dieudonne, Yang, Wanjuan, Beck, Alexandra, Mironenko, Tatiana, Hall, Caitlin, Hall, James, Mali, Iman, Richardson, Laura, Tolley, Charlotte, Morris, James, Thomas, Frances, Lleshi, Ermira, Aben, Nanne, Benes, Cyril H., Bertotti, Andrea, Trusolino, Livio, Wessels, Lodewyk, and Garnett, Mathew J.

Published
2022
Full Text
View/download PDF

15. Simulated Ablation for Detection of Cells Impacting Paracrine Signalling in Histology Analysis

Author

Taylor-King, Jake P., Baratchart, Etienne, Dhawan, Andrew, Coker, Elizabeth A., Rye, Inga Hansine, Russnes, Hege, Chapman, S. Jon, Basanta, David, and Marusyk, Andriy

Subjects
Quantitative Biology - Cell Behavior, Quantitative Biology - Quantitative Methods, Quantitative Biology - Tissues and Organs
Abstract

Intra-tumour phenotypic heterogeneity limits accuracy of clinical diagnostics and hampers the efficiency of anti-cancer therapies. Dealing with this cellular heterogeneity requires adequate understanding of its sources, which is extremely difficult, as phenotypes of tumour cells integrate hardwired (epi)mutational differences with the dynamic responses to microenvironmental cues. The later come in form of both direct physical interactions, as well as inputs from gradients of secreted signalling molecules. Furthermore, tumour cells can not only receive microenvironmental cues, but also produce them. Despite high biological and clinical importance of understanding spatial aspects of paracrine signaling, adequate research tools are largely lacking. Here, a partial differential equation (PDE) based mathematical model is developed that mimics the process of cell ablation. This model suggests how each cell might contribute to the microenvironment by either absorbing or secreting diffusible factors, and quantifies the extent to which observed intensities can be explained via diffusion mediated signalling. The model allows for the separation of phenotypic responses to signalling gradients within tumour microenvironments from the combined influence of responses mediated by direct physical contact and hardwired (epi)genetic differences. The differential equation is solved around cell membrane outlines using a finite element method (FEM). The method is applied to a multi-channel immunofluorescence in situ hybridization (iFISH) stained breast cancer histological specimen and correlations are investigated between: HER2 gene amplification; HER2 protein expression; and cell interaction with the diffusible microenvironment. This approach allows partial deconvolution of the complex inputs..., Comment: 17 pages, 5 figures

Published
2017

16. Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

Author

Bashi, Azadeh C., primary, Coker, Elizabeth A., additional, Bulusu, Krishna C., additional, Jaaks, Patricia, additional, Crafter, Claire, additional, Lightfoot, Howard, additional, Milo, Marta, additional, McCarten, Katrina, additional, Jenkins, David F., additional, van der Meer, Dieudonne, additional, Lynch, James T., additional, Barthorpe, Syd, additional, Andersen, Courtney L., additional, Barry, Simon T., additional, Beck, Alexandra, additional, Cidado, Justin, additional, Gordon, Jacob A., additional, Hall, Caitlin, additional, Hall, James, additional, Mali, Iman, additional, Mironenko, Tatiana, additional, Mongeon, Kevin, additional, Morris, James, additional, Richardson, Laura, additional, Smith, Paul D., additional, Tavana, Omid, additional, Tolley, Charlotte, additional, Thomas, Frances, additional, Willis, Brandon S., additional, Yang, Wanjuan, additional, O'Connor, Mark J., additional, McDermott, Ultan, additional, Critchlow, Susan E., additional, Drew, Lisa, additional, Fawell, Stephen E., additional, Mettetal, Jerome T., additional, and Garnett, Mathew J., additional

Published
2024
Full Text
View/download PDF

17. iPhone Accelerometry Provides a Sensitive In-Home Assessment of Age-Related Changes in Standing Balance.

Author

Coker, Elizabeth and Lubetzky, Anat V.

Subjects
COGNITIVE flexibility, HOME care services, AGE, STANDING position, POSTURAL balance, SMARTPHONES, MEDICAL care, VIDEOCONFERENCING, QUANTITATIVE research, ACCELEROMETRY, COMPARATIVE studies, DESCRIPTIVE statistics, FOOT, BIOMECHANICS
Abstract

Remote health monitoring has become increasingly important, especially in aging populations. We aimed to identify tasks that are sensitive to age-related changes in balance during fully remote, at-home balance assessment. Participants were 12 healthy young adults (mean age = 26.08 years, range: 18–33) and 12 healthy older adults (mean age = 67.33 years, range: 60–75). Participants performed standing tasks monitored via video conference while their balance was quantified using a custom iPhone application measuring mediolateral center of mass acceleration. We included three stances (feet together, tandem, and single leg) with eyes open or closed, with or without a concurrent cognitive task. Older adults demonstrated significantly more variable center of mass accelerations in tandem (p =.04, η p 2 =.25) and significantly higher (p <.01, η p 2 =.45) and more variable (p <.01, η p 2 =.44) center of mass accelerations in single leg compared with young adults. We also observed that as task challenge increased, balance dual-task cost diminished for older, but not young, adults. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

20. Abstract 5321: Large scale pan cancer drug combination screening to identify effective and actionable combinations and biomarker hypothesis

Author

Bashi, Azadeh, primary, Coker, Elizabeth A., additional, Bulusu, Krishna, additional, Milo, Marta, additional, Crafter, Claire, additional, Lynch, James, additional, Jenkins, David, additional, Lightfoot, Howard, additional, Willis, Brandon, additional, Andersen, Courtney, additional, Tavana, Omid, additional, Mongeon, Kevin, additional, Gordon, Jacob, additional, Smith, Paul, additional, Barry, Simon, additional, McDermott, Ultan, additional, Drew, Lisa, additional, Critchlow, Susan, additional, Garnett, Mathew J., additional, and Mettetal, Jerome, additional

Published
2023
Full Text
View/download PDF

21. Supplementary Figure from Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes

Author

Coker, Elizabeth A., primary, Stewart, Adam, primary, Ozer, Bugra, primary, Minchom, Anna, primary, Pickard, Lisa, primary, Ruddle, Ruth, primary, Carreira, Suzanne, primary, Popat, Sanjay, primary, O'Brien, Mary, primary, Raynaud, Florence, primary, de Bono, Johann, primary, Al-Lazikani, Bissan, primary, and Banerji, Udai, primary

Published
2023
Full Text
View/download PDF

22. Supplementary Figure 2 from AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib

Author

Flemington, Vikki, primary, Davies, Emma J., primary, Robinson, David, primary, Sandin, Linda C., primary, Delpuech, Oona, primary, Zhang, Pei, primary, Hanson, Lyndsey, primary, Farrington, Paul, primary, Bell, Sigourney, primary, Falenta, Katarzyna, primary, Gibbons, Francis D., primary, Lindsay, Nicola, primary, Smith, Aaron, primary, Wilson, Joanne, primary, Roberts, Karen, primary, Tonge, Michael, primary, Hopcroft, Philip, primary, Willis, Sophie E., primary, Roudier, Martine P., primary, Rooney, Claire, primary, Coker, Elizabeth A., primary, Jaaks, Patricia, primary, Garnett, Mathew J., primary, Fawell, Stephen E., primary, Jones, Clifford D., primary, Ward, Richard A., primary, Simpson, Iain, primary, Cosulich, Sabina C., primary, Pease, J. Elizabeth, primary, and Smith, Paul D., primary

Published
2023
Full Text
View/download PDF

23. Data from Differences in Signaling Patterns on PI3K Inhibition Reveal Context Specificity in KRAS-Mutant Cancers

Author

Stewart, Adam, primary, Coker, Elizabeth A., primary, Pölsterl, Sebastian, primary, Georgiou, Alexandros, primary, Minchom, Anna R., primary, Carreira, Suzanne, primary, Cunningham, David, primary, O'Brien, Mary ER., primary, Raynaud, Florence I., primary, de Bono, Johann S., primary, Al-Lazikani, Bissan, primary, and Banerji, Udai, primary

Published
2023
Full Text
View/download PDF

24. Supplementary Figure 1 from AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib

Author

Flemington, Vikki, primary, Davies, Emma J., primary, Robinson, David, primary, Sandin, Linda C., primary, Delpuech, Oona, primary, Zhang, Pei, primary, Hanson, Lyndsey, primary, Farrington, Paul, primary, Bell, Sigourney, primary, Falenta, Katarzyna, primary, Gibbons, Francis D., primary, Lindsay, Nicola, primary, Smith, Aaron, primary, Wilson, Joanne, primary, Roberts, Karen, primary, Tonge, Michael, primary, Hopcroft, Philip, primary, Willis, Sophie E., primary, Roudier, Martine P., primary, Rooney, Claire, primary, Coker, Elizabeth A., primary, Jaaks, Patricia, primary, Garnett, Mathew J., primary, Fawell, Stephen E., primary, Jones, Clifford D., primary, Ward, Richard A., primary, Simpson, Iain, primary, Cosulich, Sabina C., primary, Pease, J. Elizabeth, primary, and Smith, Paul D., primary

Published
2023
Full Text
View/download PDF

25. Supplementary Table 2 from AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib

Author

Flemington, Vikki, primary, Davies, Emma J., primary, Robinson, David, primary, Sandin, Linda C., primary, Delpuech, Oona, primary, Zhang, Pei, primary, Hanson, Lyndsey, primary, Farrington, Paul, primary, Bell, Sigourney, primary, Falenta, Katarzyna, primary, Gibbons, Francis D., primary, Lindsay, Nicola, primary, Smith, Aaron, primary, Wilson, Joanne, primary, Roberts, Karen, primary, Tonge, Michael, primary, Hopcroft, Philip, primary, Willis, Sophie E., primary, Roudier, Martine P., primary, Rooney, Claire, primary, Coker, Elizabeth A., primary, Jaaks, Patricia, primary, Garnett, Mathew J., primary, Fawell, Stephen E., primary, Jones, Clifford D., primary, Ward, Richard A., primary, Simpson, Iain, primary, Cosulich, Sabina C., primary, Pease, J. Elizabeth, primary, and Smith, Paul D., primary

Published
2023
Full Text
View/download PDF

26. Supplementary Figure 5 from AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib

Author

Flemington, Vikki, primary, Davies, Emma J., primary, Robinson, David, primary, Sandin, Linda C., primary, Delpuech, Oona, primary, Zhang, Pei, primary, Hanson, Lyndsey, primary, Farrington, Paul, primary, Bell, Sigourney, primary, Falenta, Katarzyna, primary, Gibbons, Francis D., primary, Lindsay, Nicola, primary, Smith, Aaron, primary, Wilson, Joanne, primary, Roberts, Karen, primary, Tonge, Michael, primary, Hopcroft, Philip, primary, Willis, Sophie E., primary, Roudier, Martine P., primary, Rooney, Claire, primary, Coker, Elizabeth A., primary, Jaaks, Patricia, primary, Garnett, Mathew J., primary, Fawell, Stephen E., primary, Jones, Clifford D., primary, Ward, Richard A., primary, Simpson, Iain, primary, Cosulich, Sabina C., primary, Pease, J. Elizabeth, primary, and Smith, Paul D., primary

Published
2023
Full Text
View/download PDF

27. Supplementary Table from Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes

Author

Coker, Elizabeth A., primary, Stewart, Adam, primary, Ozer, Bugra, primary, Minchom, Anna, primary, Pickard, Lisa, primary, Ruddle, Ruth, primary, Carreira, Suzanne, primary, Popat, Sanjay, primary, O'Brien, Mary, primary, Raynaud, Florence, primary, de Bono, Johann, primary, Al-Lazikani, Bissan, primary, and Banerji, Udai, primary

Published
2023
Full Text
View/download PDF

28. Supplementary Figure Legends from AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib

Author

Flemington, Vikki, primary, Davies, Emma J., primary, Robinson, David, primary, Sandin, Linda C., primary, Delpuech, Oona, primary, Zhang, Pei, primary, Hanson, Lyndsey, primary, Farrington, Paul, primary, Bell, Sigourney, primary, Falenta, Katarzyna, primary, Gibbons, Francis D., primary, Lindsay, Nicola, primary, Smith, Aaron, primary, Wilson, Joanne, primary, Roberts, Karen, primary, Tonge, Michael, primary, Hopcroft, Philip, primary, Willis, Sophie E., primary, Roudier, Martine P., primary, Rooney, Claire, primary, Coker, Elizabeth A., primary, Jaaks, Patricia, primary, Garnett, Mathew J., primary, Fawell, Stephen E., primary, Jones, Clifford D., primary, Ward, Richard A., primary, Simpson, Iain, primary, Cosulich, Sabina C., primary, Pease, J. Elizabeth, primary, and Smith, Paul D., primary

Published
2023
Full Text
View/download PDF

29. Supplementary Tables S1-S4 from Differences in Signaling Patterns on PI3K Inhibition Reveal Context Specificity in KRAS-Mutant Cancers

Author

Stewart, Adam, primary, Coker, Elizabeth A., primary, Pölsterl, Sebastian, primary, Georgiou, Alexandros, primary, Minchom, Anna R., primary, Carreira, Suzanne, primary, Cunningham, David, primary, O'Brien, Mary ER., primary, Raynaud, Florence I., primary, de Bono, Johann S., primary, Al-Lazikani, Bissan, primary, and Banerji, Udai, primary

Published
2023
Full Text
View/download PDF

30. Data from AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib

Author

Flemington, Vikki, primary, Davies, Emma J., primary, Robinson, David, primary, Sandin, Linda C., primary, Delpuech, Oona, primary, Zhang, Pei, primary, Hanson, Lyndsey, primary, Farrington, Paul, primary, Bell, Sigourney, primary, Falenta, Katarzyna, primary, Gibbons, Francis D., primary, Lindsay, Nicola, primary, Smith, Aaron, primary, Wilson, Joanne, primary, Roberts, Karen, primary, Tonge, Michael, primary, Hopcroft, Philip, primary, Willis, Sophie E., primary, Roudier, Martine P., primary, Rooney, Claire, primary, Coker, Elizabeth A., primary, Jaaks, Patricia, primary, Garnett, Mathew J., primary, Fawell, Stephen E., primary, Jones, Clifford D., primary, Ward, Richard A., primary, Simpson, Iain, primary, Cosulich, Sabina C., primary, Pease, J. Elizabeth, primary, and Smith, Paul D., primary

Published
2023
Full Text
View/download PDF

31. Supplementary Note from Differences in Signaling Patterns on PI3K Inhibition Reveal Context Specificity in KRAS-Mutant Cancers

Author

Stewart, Adam, primary, Coker, Elizabeth A., primary, Pölsterl, Sebastian, primary, Georgiou, Alexandros, primary, Minchom, Anna R., primary, Carreira, Suzanne, primary, Cunningham, David, primary, O'Brien, Mary ER., primary, Raynaud, Florence I., primary, de Bono, Johann S., primary, Al-Lazikani, Bissan, primary, and Banerji, Udai, primary

Published
2023
Full Text
View/download PDF

32. Supplementary Figure 4 from AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib

Author

Flemington, Vikki, primary, Davies, Emma J., primary, Robinson, David, primary, Sandin, Linda C., primary, Delpuech, Oona, primary, Zhang, Pei, primary, Hanson, Lyndsey, primary, Farrington, Paul, primary, Bell, Sigourney, primary, Falenta, Katarzyna, primary, Gibbons, Francis D., primary, Lindsay, Nicola, primary, Smith, Aaron, primary, Wilson, Joanne, primary, Roberts, Karen, primary, Tonge, Michael, primary, Hopcroft, Philip, primary, Willis, Sophie E., primary, Roudier, Martine P., primary, Rooney, Claire, primary, Coker, Elizabeth A., primary, Jaaks, Patricia, primary, Garnett, Mathew J., primary, Fawell, Stephen E., primary, Jones, Clifford D., primary, Ward, Richard A., primary, Simpson, Iain, primary, Cosulich, Sabina C., primary, Pease, J. Elizabeth, primary, and Smith, Paul D., primary

Published
2023
Full Text
View/download PDF

33. Supplementary Figure 3 from AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib

Author

Flemington, Vikki, primary, Davies, Emma J., primary, Robinson, David, primary, Sandin, Linda C., primary, Delpuech, Oona, primary, Zhang, Pei, primary, Hanson, Lyndsey, primary, Farrington, Paul, primary, Bell, Sigourney, primary, Falenta, Katarzyna, primary, Gibbons, Francis D., primary, Lindsay, Nicola, primary, Smith, Aaron, primary, Wilson, Joanne, primary, Roberts, Karen, primary, Tonge, Michael, primary, Hopcroft, Philip, primary, Willis, Sophie E., primary, Roudier, Martine P., primary, Rooney, Claire, primary, Coker, Elizabeth A., primary, Jaaks, Patricia, primary, Garnett, Mathew J., primary, Fawell, Stephen E., primary, Jones, Clifford D., primary, Ward, Richard A., primary, Simpson, Iain, primary, Cosulich, Sabina C., primary, Pease, J. Elizabeth, primary, and Smith, Paul D., primary

Published
2023
Full Text
View/download PDF

34. Supplementary Figures S1-S3 from Differences in Signaling Patterns on PI3K Inhibition Reveal Context Specificity in KRAS-Mutant Cancers

Author

Stewart, Adam, primary, Coker, Elizabeth A., primary, Pölsterl, Sebastian, primary, Georgiou, Alexandros, primary, Minchom, Anna R., primary, Carreira, Suzanne, primary, Cunningham, David, primary, O'Brien, Mary ER., primary, Raynaud, Florence I., primary, de Bono, Johann S., primary, Al-Lazikani, Bissan, primary, and Banerji, Udai, primary

Published
2023
Full Text
View/download PDF

35. Supplementary Data from Differences in Signaling Patterns on PI3K Inhibition Reveal Context Specificity in KRAS-Mutant Cancers

Author

Stewart, Adam, primary, Coker, Elizabeth A., primary, Pölsterl, Sebastian, primary, Georgiou, Alexandros, primary, Minchom, Anna R., primary, Carreira, Suzanne, primary, Cunningham, David, primary, O'Brien, Mary ER., primary, Raynaud, Florence I., primary, de Bono, Johann S., primary, Al-Lazikani, Bissan, primary, and Banerji, Udai, primary

Published
2023
Full Text
View/download PDF

36. Supplementary Table 3 from AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib

Author

Flemington, Vikki, primary, Davies, Emma J., primary, Robinson, David, primary, Sandin, Linda C., primary, Delpuech, Oona, primary, Zhang, Pei, primary, Hanson, Lyndsey, primary, Farrington, Paul, primary, Bell, Sigourney, primary, Falenta, Katarzyna, primary, Gibbons, Francis D., primary, Lindsay, Nicola, primary, Smith, Aaron, primary, Wilson, Joanne, primary, Roberts, Karen, primary, Tonge, Michael, primary, Hopcroft, Philip, primary, Willis, Sophie E., primary, Roudier, Martine P., primary, Rooney, Claire, primary, Coker, Elizabeth A., primary, Jaaks, Patricia, primary, Garnett, Mathew J., primary, Fawell, Stephen E., primary, Jones, Clifford D., primary, Ward, Richard A., primary, Simpson, Iain, primary, Cosulich, Sabina C., primary, Pease, J. Elizabeth, primary, and Smith, Paul D., primary

Published
2023
Full Text
View/download PDF

37. Supplementary Figure 6 from AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib

Author

Flemington, Vikki, primary, Davies, Emma J., primary, Robinson, David, primary, Sandin, Linda C., primary, Delpuech, Oona, primary, Zhang, Pei, primary, Hanson, Lyndsey, primary, Farrington, Paul, primary, Bell, Sigourney, primary, Falenta, Katarzyna, primary, Gibbons, Francis D., primary, Lindsay, Nicola, primary, Smith, Aaron, primary, Wilson, Joanne, primary, Roberts, Karen, primary, Tonge, Michael, primary, Hopcroft, Philip, primary, Willis, Sophie E., primary, Roudier, Martine P., primary, Rooney, Claire, primary, Coker, Elizabeth A., primary, Jaaks, Patricia, primary, Garnett, Mathew J., primary, Fawell, Stephen E., primary, Jones, Clifford D., primary, Ward, Richard A., primary, Simpson, Iain, primary, Cosulich, Sabina C., primary, Pease, J. Elizabeth, primary, and Smith, Paul D., primary

Published
2023
Full Text
View/download PDF

38. Figure S3 from AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia

Author

Balachander, Srividya B., primary, Criscione, Steven W., primary, Byth, Kate F., primary, Cidado, Justin, primary, Adam, Ammar, primary, Lewis, Paula, primary, Macintyre, Terry, primary, Wen, Shenghua, primary, Lawson, Deborah, primary, Burke, Kathleen, primary, Lubinski, Tristan, primary, Tyner, Jeffrey W., primary, Kurtz, Stephen E., primary, McWeeney, Shannon K., primary, Varnes, Jeffrey, primary, Diebold, R. Bruce, primary, Gero, Thomas, primary, Ioannidis, Stephanos, primary, Hennessy, Edward J., primary, McCoull, William, primary, Saeh, Jamal C., primary, Tabatabai, Areya, primary, Tavana, Omid, primary, Su, Nancy, primary, Schuller, Alwin, primary, Garnett, Mathew J., primary, Jaaks, Patricia, primary, Coker, Elizabeth A., primary, Gregory, Gareth P., primary, Newbold, Andrea, primary, Johnstone, Ricky W., primary, Gangl, Eric, primary, Wild, Martin, primary, Zinda, Michael, primary, Secrist, J. Paul, primary, Davies, Barry R., primary, Fawell, Stephen E., primary, and Gibbons, Francis D., primary

Published
2023
Full Text
View/download PDF

39. Effect of Visual Condition on Performance of Balance-Related Tasks in Elite Dance Students.

Author

Coker, Elizabeth and Kaminski, Terry

Subjects
DANCE students, BALLET dancing, TASK performance, ANKLE, MOTION analysis, MOTOR learning, POSTURAL balance, BODY movement, STUDENTS, DANCE
Abstract

The purpose of this study was to investigate the effects of visual condition (low light, full light, and full light with mirror) on balance control and technical form during two technical dance movements in a group of elite collegiate dance students. Dancers demonstrated higher center of pressure velocity indicating lower control while performing a static dance task (parallel relevé retiré) and a dynamic dance task (fondu relevé en croix) under low light conditions than either lighted condition. Measures of Western ballet technique (pelvic obliquity, knee extension, and ankle plantar flexion) showed no decrement under low light conditions. No effect of concurrent mirror feedback was found on either center of pressure velocity or technical requirements of the dance tasks. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

42. Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes

Author

Coker, Elizabeth A., primary, Stewart, Adam, additional, Ozer, Bugra, additional, Minchom, Anna, additional, Pickard, Lisa, additional, Ruddle, Ruth, additional, Carreira, Suzanne, additional, Popat, Sanjay, additional, O'Brien, Mary, additional, Raynaud, Florence, additional, de Bono, Johann, additional, Al-Lazikani, Bissan, additional, and Banerji, Udai, additional

Published
2022
Full Text
View/download PDF

46. canSAR: update to the cancer translational research and drug discovery knowledgebase

Author

Coker, Elizabeth A, Mitsopoulos, Costas, Tym, Joesph E, Komianou, Angeliki, Kannas, Christos, Di Micco, Patrizio, Villasclaras Fernandez, Eloy, Ozer, Bugra, Antolin, Albert A, Workman, Paul, and Al-Lazikani, Bissan

Subjects
Translational Research, Biomedical, User-Computer Interface, Databases, Pharmaceutical, Protein Conformation, Knowledge Bases, Neoplasms, Drug Discovery, Protein Interaction Mapping, Database Issue, Humans, Antineoplastic Agents
Abstract

canSAR (http://cansar.icr.ac.uk) is a public, freely available, integrative translational research and drug discovery knowlegebase. canSAR informs researchers to help solve key bottlenecks in cancer translation and drug discovery. It integrates genomic, protein, pharmacological, drug and chemical data with structural biology, protein networks and unique, comprehensive and orthogonal ‘druggability’ assessments. canSAR is widely used internationally by academia and industry. Here we describe major enhancements to canSAR including new and expanded data. We also describe the first components of canSARblack—an advanced, responsive, multi-device compatible redesign of canSAR with a question-led interface.

Published
2018

47. Postural Control under Cognitive Load: Evidence of Increased Automaticity Revealed by Center-of-Pressure and Head Kinematics.

Author

Lubetzky, Anat V., Coker, Elizabeth, Arie, Liraz, Aharoni, Moshe M. H., and Krasovsky, Tal

Abstract

How postural responses change with sensory perturbations while also performing a cognitive task is still debatable. This study investigated this question via comprehensive assessment of postural sway, head kinematics and their coupling. Twenty-three healthy young adults stood in tandem with eyes open or wearing the HTC Vive Head-Mounted Display (HMD) with a static or dynamic (i.e., movement in the anterior-posterior direction at 5 mm or 32 mm at 0.2 Hz) 3-wall stars display. On half of the trials, participants performed a cognitive serial subtraction task. Medio-lateral center-of-pressure (COP) path significantly increased with the cognitive task, particularly with dynamic visuals whereas medio-lateral variance decreased with the cognitive task. Head path and velocity significantly increased with the cognitive task in both directions while variance decreased. Head-COP cross-correlations ranged between 0.78 and 0.66. These findings, accompanied by frequency analysis, suggest that postural control switched to primarily relying on somatosensory input under challenging cognitive load conditions. Several differences between head and COP suggest that head kinematics contribute an important additional facet of postural control and the relationship between head and COP may depend on task and stance position. The potential of HMDs for clinical assessments of balance needs to be further explored. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

50. Selfhood and social distance: toward a cultural understanding of psychiatric stigma in Egypt

Author

Coker, Elizabeth M.

Subjects
Mental illness -- Psychological aspects, Mental illness -- Social aspects, Health, Social sciences
Abstract

Psychiatric stigma is a concept that is often used uncritically by policy-makers to explain the underutilization of professional psychiatric services in non-Western societies. Stigma, however, is a multi-determined process manifestations and effects of which cannot be viewed separately from the larger social and cultural context. The present paper presents the results of a qualitative study of psychiatric stigma in Egypt from the perspective of lay respondents. A vignette method was used to elicit judgments of social distance and qualitative responses to stories depicting psychosis, depression, alcohol abuse and a 'possession state' from 208 respondents recruited through their places of work. The results indicated that while stigma does exist in Egypt, the form that it takes must be understood with reference to Egyptian notions of selfhood that locate behavioral disturbances in the intersubjective rather than intrapsychic realm. On the one hand, individual blame is diffused as responsibility for the illness and its cure is placed in the social, not personal (or biological) realm. On the other, behavioral disorders that threaten the social fabric of society are particularly stigmatized and often met with social rejection. Keywords: Stigma; Mental illness; Egypt; Psychiatry

Published
2005

Catalog

Books, media, physical & digital resources
See catalog results