Search

Your search keyword '"Colantonio, Lisandro"' showing total 648 results
Start Over Author "Colantonio, Lisandro"
648 results on '"Colantonio, Lisandro"'

1. Recurrent Atherosclerotic Cardiovascular Disease Events Potentially Prevented with Guideline-Recommended Cholesterol-Lowering Therapy following Myocardial Infarction

Author

Sakhuja, Swati, Bittner, Vera A., Brown, Todd M., Farkouh, Michael E., Levitan, Emily B., Safford, Monika M., Woodward, Mark, Chen, Ligong, Sun, Ruoyan, Dhalwani, Nafeesa, Jones, Jenna, Kalich, Bethany, Exter, Jason, Muntner, Paul, Rosenson, Robert S., and Colantonio, Lisandro D.

Published
2024
Full Text
View/download PDF

15. Risk-enhancing factors and social determinants of health in risk assessment for atherosclerotic cardiovascular disease.

Author

Zhang, Yiyi, An, Jaejin, Xia, Mengying, Zhou, Hui, Sun, Yifei, Chung, Joanie, Zhou, Mengnan, Choi, Soon Kyu, Morrissette, Kerresa L., Muntner, Paul, Safford, Monika M., Isasi, Carmen R., Kanaya, Alka M., Bellows, Brandon K., Colantonio, Lisandro D., Reynolds, Kristi, and Moran, Andrew E.

Abstract

Background: The Pooled Cohort Equations (PCEs) do not accurately estimate atherosclerotic cardiovascular disease (ASCVD) risk in certain populations. The 2018 AHA/ACC cholesterol guideline identified risk-enhancing factors as a supplement to PCEs-based risk assessment. However, the role of each risk-enhancing factor in ASCVD risk assessment has not been well quantified. Further, social determinants of health (SDOH) are not included in the PCEs nor considered as risk-enhancing factors in the US cholesterol guideline. We sought to evaluate ASCVD risk associated with each risk-enhancing factor and commonly collected SDOH including education, income, and employment status, and to assess if adding risk-enhancing factors and SDOH to the PCEs improve ASCVD risk prediction. Methods: We included individuals aged 40 to 75 years, without ASCVD or diabetes at baseline, and with low-density lipoprotein cholesterol 70–189 mg/dL from two contemporary prospective cohort studies (MESA and REGARDS) and from Kaiser Permanente Southern California (KPSC). The primary endpoint was incident ASCVD defined as nonfatal myocardial infarction, fatal coronary heart disease, or fatal or nonfatal stroke over a 10-year period (median follow-up 10 years). We used Cox proportional hazards models to estimate associations between risk-enhancing factors and SDOH with ASCVD. We also assessed changes in model performance after adding risk-enhancing factors and SDOH to the PCEs. Results: We included 13,863 adults (mean age 60.7 years) from the prospective cohorts and 307,931 adults (mean age 54.8 years) from KPSC. Risk-enhancing factors including hypercholesterolemia, hypertriglyceridemia, metabolic syndrome, and chronic kidney disease were associated with a higher ASCVD risk, independent of 10-year risk estimated by the PCEs. Low education, low income, and unemployment were also associated with higher ASCVD risk. While adding individual risk-enhancing factors or SDOH to the PCEs had limited impact on model performance, adding multiple risk-enhancing factors and SDOH simultaneously led to modest improvements in discrimination (C-index increased by up to 0.07), calibration (integrated Brier score reduced by up to 2.3%), and net reclassification improvement up to 41.4%. Conclusions: These findings suggest including SDOH and risk-enhancing factors may improve ASCVD risk assessment. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

16. Association of Integrase Strand Transfer Inhibitor-Based Antiretroviral Therapy With Blood Pressure and Sustained Hypertension in People With Human Immunodeficiency Virus.

Author

Siddiqui, Mohammed, Burkholder, Greer A, Judd, Eric, Wang, Zhixin, Colantonio, Lisandro D, Ghazi, Lama, Shimbo, Daichi, Willig, Amanda L, Overton, Edgar T, Oparil, Suzanne, Levitan, Emily B, Heath, Sonya L, and Muntner, Paul

Subjects
DIASTOLIC blood pressure, SYSTOLIC blood pressure, HIV, BLOOD pressure, WEIGHT gain
Abstract

BACKGROUND Integrase strand transfer inhibitors (INSTIs) are a commonly used antiretroviral therapy (ART) class in people with human immunodeficiency virus (HIV) and associated with weight gain. We studied the association of INSTI-based ART with systolic and diastolic blood pressure (SBP and DBP). METHODS We recruited 50 people taking INSTI-based ART and 40 people taking non-INSTI-based ART with HIV and hypertension from the University of Alabama at Birmingham HIV clinic. Office BP was measured unattended using an automated (AOBP) device. Awake, asleep, and 24-hour BP were measured through ambulatory BP monitoring. Among participants with SBP ≥130 mm Hg or DBP ≥80 mm Hg on AOBP, sustained hypertension was defined as awake SBP ≥130 mm Hg or DBP ≥80 mm Hg. RESULTS Mean SBP and DBP were higher among participants taking INSTI- vs. non-INSTI-based ART (AOBP-SBP/DBP: 144.7/83.8 vs. 135.3/79.3 mm Hg; awake-SBP/DBP: 143.2/80.9 vs. 133.4/76.3 mm Hg; asleep-SBP/DBP: 133.3/72.9 vs. 120.3/65.4 mm Hg; 24-hour-SBP/DBP: 140.4/78.7 vs. 130.0/73.7 mm Hg). After multivariable adjustment, AOBP, awake, asleep, and 24-hour SBP were 12.5 (95% confidence interval [CI] 5.0–20.1), 9.8 (95% CI 3.6–16.0), 10.4 (95% CI 2.0–18.9), and 9.8 (95% CI 4.2–15.4) mm Hg higher among those taking INSTI- vs. non-INSTI-based ART, respectively. AOBP, awake, asleep, and 24-hour DBP were 7.5 (95% CI 0.3–14.6), 6.1 (95% CI 0.3–11.8), 7.5 (95% CI 1.4–13.6), and 6.1 (95% CI 0.9–11.3) mm Hg higher among those taking INSTI- vs. non-INSTI-based ART after multivariable adjustment. All participants had SBP ≥130 mm Hg or DBP ≥80 mm Hg on AOBP and 97.9% and 65.7% of participants taking INSTI- and non-INSTI-based ART had sustained hypertension, respectively. CONCLUSIONS INSTI-based ART was associated with higher SBP and DBP than non-INSTI-based ART. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

18. Association Between Young Adult Characteristics and Blood Pressure Trajectories

Author

An, Jaejin, primary, Fischer, Heidi, additional, Ni, Liang, additional, Xia, Mengying, additional, Choi, Soon Kyu, additional, Morrissette, Kerresa L., additional, Wei, Rong, additional, Reynolds, Kristi, additional, Muntner, Paul, additional, Safford, Monika M., additional, Moran, Andrew E., additional, Bellows, Brandon K., additional, Isasi, Carmen R., additional, Allen, Norrina B., additional, Xanthakis, Vanessa, additional, Colantonio, Lisandro D., additional, and Zhang, Yiyi, additional

Published
2024
Full Text
View/download PDF

21. Atherosclerotic Cardiovascular Disease Events in Adults With CKD Taking a Moderate- or High-Intensity Statin: The Chronic Renal Insufficiency Cohort (CRIC) Study

Author

Poudel, Bharat, Rosenson, Robert S., Bittner, Vera, Gutiérrez, Orlando M., Anderson, Amanda H., Woodward, Mark, Deo, Rajat, Carson, April P., Mues, Katherine E., Dluzniewski, Paul J., Jaar, Bernard G., Lora, Claudia M., Taliercio, Jonathan, Muntner, Paul, and Colantonio, Lisandro D.

Published
2021
Full Text
View/download PDF

26. Trends in the Prevalence of Multiple Chronic Conditions Among US Adults With Hypertension From 1999–2000 Through 2017–2020.

Author

Alanaeme, Chibuike J, Ghazi, Lama, Akinyelure, Oluwasegun P, Wen, Ying, Christenson, Ashley, Poudel, Bharat, Dooley, Erin E, Chen, Ligong, Hardy, Shakia T, Foti, Kathryn, Bowling, C Barrett, Long, Michelle T, Colantonio, Lisandro D, and Muntner, Paul

Subjects
CHRONIC diseases, DYSLIPIDEMIA, HEALTH & Nutrition Examination Survey, HYPERTENSION, HEPATITIS B, CHRONIC kidney failure, ADULTS
Abstract

BACKGROUND The prevalence of many chronic conditions has increased among US adults. Many adults with hypertension have other chronic conditions. METHODS We estimated changes in the age-adjusted prevalence of multiple (≥3) chronic conditions, not including hypertension, using data from the National Health and Nutrition Examination Survey, from 1999–2000 to 2017–2020, among US adults with (n = 24,851) and without (n = 24,337 hypertension. Hypertension included systolic blood pressure (BP) ≥130 mm Hg, diastolic BP ≥80 mm Hg, or antihypertensive medication use. We studied 14 chronic conditions: arthritis, asthma, cancer, coronary heart disease, chronic kidney disease, depression, diabetes, dyslipidemia, hepatitis B, hepatitis C, heart failure, lung disease, obesity, and stroke. RESULTS From 1999–2000 to 2017–2020, the age-adjusted mean number of chronic conditions increased more among US adults with vs. without hypertension (2.2 to 2.8 vs. 1.7 to 2.0; P -interaction <0.001). Also, the age-adjusted prevalence of multiple chronic conditions increased from 39.0% to 52.0% among US adults with hypertension and from 26.0% to 30.0% among US adults without hypertension (P -interaction = 0.022). In 2017–2020, after age, gender, and race/ethnicity adjustment, US adults with hypertension were 1.94 (95% confidence interval: 1.72–2.18) times as likely to have multiple chronic conditions compared to those without hypertension. In 2017–2020, dyslipidemia, obesity, and arthritis were the most common 3 co-occurring chronic conditions among US adults with and without hypertension (age-adjusted prevalence 16.5% and 3.1%, respectively). CONCLUSIONS In 2017–2020, more than half of US adults with hypertension had ≥3 additional chronic conditions, a substantial increase from 20 years ago. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

30. Risk Prediction for Atherosclerotic Cardiovascular Disease With and Without Race Stratification

Author

Ghosh, Arnab K., primary, Venkatraman, Sara, additional, Nanna, Michael G., additional, Safford, Monika M., additional, Colantonio, Lisandro D., additional, Brown, Todd M., additional, Pinheiro, Laura C., additional, Peterson, Eric D., additional, Navar, Ann Marie, additional, Sterling, Madeline R., additional, Soroka, Orysya, additional, Nahid, Musarrat, additional, Banerjee, Samprit, additional, and Goyal, Parag, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results