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4. miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer

Author

Barisciano, Giovannina, Colangelo, Tommaso, Rosato, Valeria, Muccillo, Livio, Taddei, Maria Letizia, Ippolito, Luigi, Chiarugi, Paola, Galgani, Mario, Bruzzaniti, Sara, Matarese, Giuseppe, Fassan, Matteo, Agostini, Marco, Bergamo, Francesca, Pucciarelli, Salvatore, Carbone, Annalucia, Mazzoccoli, Gianluigi, Colantuoni, Vittorio, Bianchi, Fabrizio, and Sabatino, Lina

Published
2020
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5. Supplementary Figures 1-9 from Centrosome Linker–induced Tetraploid Segregation Errors Link Rhabdoid Phenotypes and Lethal Colorectal Cancers

Author

Remo, Andrea, primary, Manfrin, Erminia, primary, Parcesepe, Pietro, primary, Ferrarini, Alberto, primary, Han, Hye Seung, primary, Mickys, Ugnius, primary, Laudanna, Carmelo, primary, Simbolo, Michele, primary, Malanga, Donatella, primary, Oliveira, Duarte Mendes, primary, Baritono, Elisabetta, primary, Colangelo, Tommaso, primary, Sabatino, Lina, primary, Giuliani, Jacopo, primary, Molinari, Enrico, primary, Garonzi, Marianna, primary, Xumerle, Luciano, primary, Delledonne, Massimo, primary, Giordano, Guido, primary, Ghimenton, Claudio, primary, Lonardo, Fortunato, primary, D'angelo, Fulvio, primary, Grillo, Federica, primary, Mastracci, Luca, primary, Viglietto, Giuseppe, primary, Ceccarelli, Michele, primary, Colantuoni, Vittorio, primary, Scarpa, Aldo, primary, and Pancione, Massimo, primary

Published
2023
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6. Supplementary Tables 1-9 from Centrosome Linker–induced Tetraploid Segregation Errors Link Rhabdoid Phenotypes and Lethal Colorectal Cancers

Author

Remo, Andrea, primary, Manfrin, Erminia, primary, Parcesepe, Pietro, primary, Ferrarini, Alberto, primary, Han, Hye Seung, primary, Mickys, Ugnius, primary, Laudanna, Carmelo, primary, Simbolo, Michele, primary, Malanga, Donatella, primary, Oliveira, Duarte Mendes, primary, Baritono, Elisabetta, primary, Colangelo, Tommaso, primary, Sabatino, Lina, primary, Giuliani, Jacopo, primary, Molinari, Enrico, primary, Garonzi, Marianna, primary, Xumerle, Luciano, primary, Delledonne, Massimo, primary, Giordano, Guido, primary, Ghimenton, Claudio, primary, Lonardo, Fortunato, primary, D'angelo, Fulvio, primary, Grillo, Federica, primary, Mastracci, Luca, primary, Viglietto, Giuseppe, primary, Ceccarelli, Michele, primary, Colantuoni, Vittorio, primary, Scarpa, Aldo, primary, and Pancione, Massimo, primary

Published
2023
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7. Supplementary Materials and Methods from Centrosome Linker–induced Tetraploid Segregation Errors Link Rhabdoid Phenotypes and Lethal Colorectal Cancers

Author

Remo, Andrea, primary, Manfrin, Erminia, primary, Parcesepe, Pietro, primary, Ferrarini, Alberto, primary, Han, Hye Seung, primary, Mickys, Ugnius, primary, Laudanna, Carmelo, primary, Simbolo, Michele, primary, Malanga, Donatella, primary, Oliveira, Duarte Mendes, primary, Baritono, Elisabetta, primary, Colangelo, Tommaso, primary, Sabatino, Lina, primary, Giuliani, Jacopo, primary, Molinari, Enrico, primary, Garonzi, Marianna, primary, Xumerle, Luciano, primary, Delledonne, Massimo, primary, Giordano, Guido, primary, Ghimenton, Claudio, primary, Lonardo, Fortunato, primary, D'angelo, Fulvio, primary, Grillo, Federica, primary, Mastracci, Luca, primary, Viglietto, Giuseppe, primary, Ceccarelli, Michele, primary, Colantuoni, Vittorio, primary, Scarpa, Aldo, primary, and Pancione, Massimo, primary

Published
2023
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8. Genetics of medullary thyroid cancer: An overview

Author

Accardo, Giacomo, Conzo, Giovanni, Esposito, Daniela, Gambardella, Claudio, Mazzella, Marco, Castaldo, Filomena, Di Donna, Carlo, Polistena, Andrea, Avenia, Nicola, Colantuoni, Vittorio, Giugliano, Dario, and Pasquali, Daniela

Published
2017
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15. Everolimus as first line therapy for pancreatic neuroendocrine tumours: current knowledge and future perspectives

Author

Gallo, Marco, Malandrino, Pasqualino, Fanciulli, Giuseppe, Rota, Francesca, Faggiano, Antongiulio, Colao, Annamaria, Colao, Annamaria, Albertelli, Manuela, Amoroso, Vito, Arvat, Emanuela, Badalamenti, Giuseppe, Bajetta, Emilio, Baldelli, Roberto, Bianchi, Antonio, Botti, Gerardo, Buzzoni, Roberto, Campana, Davide, Carnaghi, Carlo, Cartenì, Giacomo, Cingarlini, Sara, Circelli, Luisa, Colantuoni, Vittorio, Coppa, Jorgelina, Corcione, Francesco, Davı´, Maria Vittoria, De Rosa, Gaetano, Degli Uberti, Ettore, Del Basso De Caro, Marialaura, Di Sarno, Antonella, Falconi, Massimo, Ferolla, Piero, Ferone, Diego, Fiore, Francesco, Gaudenzi, Germano, Giordano, Carla, Giuffrida, Dario, Grossrubatscher, Erika Maria, Guadagno, Elia, Guarnotta, Valentina, Izzo, Francesco, Lania, Andrea, Lastoria, Secondo, Leo, Silvana, Lo Calzo, Fabio, Logoluso, Francesco, Manzoni, Marco, Marchetti, Massimo, Martini, Chiara, Messina, Erika, Milione, Massimo, Modica, Roberta, Montesarchio, Vincenzo, Muto, Pietro, Nappi, Oscar, Nazzari, Elena, Panzuto, Francesco, Pia, Anna, Piovesan, Alessandro, Pizza, Genoveffa, Pontecorvi, Alfredo, Pusceddu, Sara, Razzore, Paola, Riccardi, Ferdinando, Rindi, Guido, Sciammarella, Concetta, Spada, Francesca, Tafuto, Salvatore, Versari, Annibale, Vitale, Giovanni, Zatelli, Maria Chiara, and On behalf of NIKE Group

Published
2017
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17. An Approach to Identify miRNA Associated with Cancer Altered Pathways

Author

Ventola, Giovanna Maria, Colaprico, Antonio, D’Angelo, Fulvio, Colantuoni, Vittorio, Viglietto, Giuseppe, Cerulo, Luigi, Ceccarelli, Michele, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Petrosino, Alfredo, editor, Maddalena, Lucia, editor, and Pala, Pietro, editor

Published
2013
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18. Correction: miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer

Author

Barisciano, Giovannina, Colangelo, Tommaso, Rosato, Valeria, Muccillo, Livio, Taddei, Maria Letizia, Ippolito, Luigi, Chiarugi, Paola, Galgani, Mario, Bruzzaniti, Sara, Matarese, Giuseppe, Fassan, Matteo, Agostini, Marco, Bergamo, Francesca, Pucciarelli, Salvatore, Carbone, Annalucia, Mazzoccoli, Gianluigi, Colantuoni, Vittorio, Bianchi, Fabrizio, and Sabatino, Lina

Published
2020
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19. SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis

Author

Pranzini, Erica, primary, Pardella, Elisa, additional, Muccillo, Livio, additional, Leo, Angela, additional, Nesi, Ilaria, additional, Santi, Alice, additional, Parri, Matteo, additional, Zhang, Tong, additional, Uribe, Alejandro Huerta, additional, Lottini, Tiziano, additional, Sabatino, Lina, additional, Caselli, Anna, additional, Arcangeli, Annarosa, additional, Raugei, Giovanni, additional, Colantuoni, Vittorio, additional, Cirri, Paolo, additional, Chiarugi, Paola, additional, Maddocks, Oliver D.K., additional, Paoli, Paolo, additional, and Taddei, Maria Letizia, additional

Published
2022
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20. Current concepts of pheochromocytoma

Author

Conzo, Giovanni, Pasquali, Daniela, Colantuoni, Vittorio, Circelli, Luisa, Tartaglia, Ernesto, Gambardella, Claudio, Napolitano, Salvatore, Mauriello, Claudio, Avenia, Nicola, Santini, Luigi, and Sinisi, Antonio Agostino

Published
2014
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33. CXCR4 engagement triggers CD47 internalization and antitumor immunization in a mouse model of mesothelioma

Author

Mezzapelle, Rosanna, primary, De Marchis, Francesco, additional, Passera, Chiara, additional, Leo, Manuela, additional, Brambilla, Francesca, additional, Colombo, Federica, additional, Casalgrandi, Maura, additional, Preti, Alessandro, additional, Zambrano, Samuel, additional, Castellani, Patrizia, additional, Ertassi, Riccardo, additional, Silingardi, Marco, additional, Caprioglio, Francesca, additional, Basso, Veronica, additional, Boldorini, Renzo, additional, Carretta, Angelo, additional, Sanvito, Francesca, additional, Rena, Ottavio, additional, Rubartelli, Anna, additional, Sabatino, Lina, additional, Mondino, Anna, additional, Crippa, Massimo P, additional, Colantuoni, Vittorio, additional, and Bianchi, Marco E, additional

Published
2021
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35. Transplacental delivery of retinoid: the role of retinol-binding protein and lipoprotein retinyl ester

Author

Quadro, Loredana, Hamberger, Leora, Gottesman, Max E., Colantuoni, Vittorio, Ramakrishnan, Rajasekhar, and Blaner, William S.

Subjects
Retinoids -- Research, Biological sciences
Abstract

Retinoids are required for normal embryonic development. Both embryonic retinoid deficiency and excess result in congenital malformations. There is little understanding of the physiology underlying retinoid transfer from the maternal circulation to the embryo. We now report studies that explore this process using retinol-binding protein-deficient (RB[P.sup.-/-]) mice and mice that express human RBP on the RBP.sup.-/-] background. Our studies establish that dietary retinoid, bound to lipoproteins, can serve as an important source for meeting tissue retinoid requirements during embryogenesis. Indeed, retinyl ester concentrations in the circulations of pregnant RB[P.sup.-/-] mice are significantly elevated over those observed in wild-type mice, suggesting that lipoprotein retinyl esters may compensate for the absence of retinol-RBP during pregnancy. We also demonstrate, contrary to earlier proposals, that maternal RBP does not cross the placenta and cannot enter the fetal circulation. Overall, our data indicate that both retinol-RBP and retinyl esters bound to lipoproteins are able to provide sufficient retinoid to the embryo to allow for normal embryonic development. retinol; chylomicron; vitamin A; embryogenesis; placenta

Published
2004

37. The Camp-HMGA1-RBP4 System

Author

Chiefari, Eusebio, primary, Paonessa, Francesco, additional, Iiritano, Stefania, additional, Le Pera, Ilaria, additional, Palmieri, Dario, additional, Brunetti, Giuseppe, additional, Lupo, Angelo, additional, Colantuoni, Vittorio, additional, Foti, Daniela, additional, Gulletta, Elio, additional, De Sarro, Giovambattista, additional, Fusco, Alfredo, additional, and Brunetti, Antonio, additional

Published
2011
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45. Centrosome Linker–induced Tetraploid Segregation Errors Link Rhabdoid Phenotypes and Lethal Colorectal Cancers

Author

Remo, Andrea, primary, Manfrin, Erminia, additional, Parcesepe, Pietro, additional, Ferrarini, Alberto, additional, Han, Hye Seung, additional, Mickys, Ugnius, additional, Laudanna, Carmelo, additional, Simbolo, Michele, additional, Malanga, Donatella, additional, Oliveira, Duarte Mendes, additional, Baritono, Elisabetta, additional, Colangelo, Tommaso, additional, Sabatino, Lina, additional, Giuliani, Jacopo, additional, Molinari, Enrico, additional, Garonzi, Marianna, additional, Xumerle, Luciano, additional, Delledonne, Massimo, additional, Giordano, Guido, additional, Ghimenton, Claudio, additional, Lonardo, Fortunato, additional, D'angelo, Fulvio, additional, Grillo, Federica, additional, Mastracci, Luca, additional, Viglietto, Giuseppe, additional, Ceccarelli, Michele, additional, Colantuoni, Vittorio, additional, Scarpa, Aldo, additional, and Pancione, Massimo, additional

Published
2018
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46. The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis

Author

Foti Daniela, Colantuoni Vittorio, Brunetti Giuseppe, Lupo Angelo, Palmieri Dario, Le Pera Ilaria, Iiritano Stefania, Paonessa Francesco, Chiefari Eusebio, Gulletta Elio, De Sarro Giovambattista, Fusco Alfredo, and Brunetti Antonio

Subjects
Biology (General), QH301-705.5
Abstract

Abstract Background We previously showed that mice lacking the high mobility group A1 gene (Hmga1-knockout mice) developed a type 2-like diabetic phenotype, in which cell-surface insulin receptors were dramatically reduced (below 10% of those in the controls) in the major targets of insulin action, and glucose intolerance was associated with increased peripheral insulin sensitivity. This particular phenotype supports the existence of compensatory mechanisms of insulin resistance that promote glucose uptake and disposal in peripheral tissues by either insulin-dependent or insulin-independent mechanisms. We explored the role of these mechanisms in the regulation of glucose homeostasis by studying the Hmga1-knockout mouse model. Also, the hypothesis that increased insulin sensitivity in Hmga1-deficient mice could be related to the deficit of an insulin resistance factor is discussed. Results We first show that HMGA1 is needed for basal and cAMP-induced retinol-binding protein 4 (RBP4) gene and protein expression in living cells of both human and mouse origin. Then, by employing the Hmga1-knockout mouse model, we provide evidence for the identification of a novel biochemical pathway involving HMGA1 and the RBP4, whose activation by the cAMP-signaling pathway may play an essential role for maintaining glucose metabolism homeostasis in vivo, in certain adverse metabolic conditions in which insulin action is precluded. In comparative studies of normal and mutant mice, glucagon administration caused a considerable upregulation of HMGA1 and RBP4 expression both at the mRNA and protein level in wild-type animals. Conversely, in Hmga1-knockout mice, basal and glucagon-mediated expression of RBP4 was severely attenuated and correlated inversely with increased Glut4 mRNA and protein abundance in skeletal muscle and fat, in which the activation state of the protein kinase Akt, an important downstream mediator of the metabolic effects of insulin on Glut4 translocation and carbohydrate metabolism, was simultaneously increased. Conclusion These results indicate that HMGA1 is an important modulator of RBP4 gene expression in vivo. Further, they provide evidence for the identification of a novel biochemical pathway involving the cAMP-HMGA1-RBP4 system, whose activation may play a role in glucose homeostasis in both rodents and humans. Elucidating these mechanisms has importance for both fundamental biology and therapeutic implications.

Published
2009
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48. A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability

Author

Vasaturo, Michele, primary, Fiengo, Lorenzo, additional, De Tommasi, Nunziatina, additional, Sabatino, Lina, additional, Ziccardi, Pamela, additional, Colantuoni, Vittorio, additional, Bruno, Maurizio, additional, Cerchia, Carmen, additional, Novellino, Ettore, additional, Lupo, Angelo, additional, Lavecchia, Antonio, additional, and Piaz, Fabrizio Dal, additional

Published
2017
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49. Friend or foe?

Author

Colangelo, Tommaso, primary, Polcaro, Giovanna, additional, Muccillo, Livio, additional, D'Agostino, Giovanna, additional, Rosato, Valeria, additional, Ziccardi, Pamela, additional, Lupo, Angelo, additional, Mazzoccoli, Gianluigi, additional, Sabatino, Lina, additional, and Colantuoni, Vittorio, additional

Published
2017
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50. thyroid carcinoma

Author

PASQUALI, Daniela, Circelli, Luisa, Faggiano, Antongiulio, Pancione, Massimo, Renzullo, Andrea, Elisei, Rossella, Romei, Cristina, Accardo, Giacomo, Coppola, Viviana Raffaella, De Palma, Maurizio, Ferolla, Piero, Grimaldi, Franco, Colao, Annamaria, Colantuoni, Vittorio, Pasquali, Daniela, Circelli, Luisa, Faggiano, Antongiulio, Pancione, Massimo, Renzullo, Andrea, Elisei, Rossella, Romei, Cristina, Accardo, Giacomo, Coppola, Viviana Raffaella, De Palma, Maurizio, Ferolla, Piero, Grimaldi, Franco, Colao, Annamaria, and Colantuoni, Vittorio

Subjects
Adult, Calcitonin, Male, Medicine (all), Middle Aged, Polymorphism, Single Nucleotide, Carcinoma, Neuroendocrine, Intracellular Signaling Peptides and Protein, Proportional Hazards Model, Female, Multivariate Analysi, Cyclin-Dependent Kinase Inhibitor p27, Thyroid Neoplasm, Human
Abstract

CDKN1B encodes the cyclin-dependent kinase inhibitor p27Kip1 and is mutated in multiple endocrine neoplasia-like syndromes. CDKN1B also harbors single nucleotide polymorphisms; the T/G transversion at nucleotide 326 (the V109G variant) has been reported to be protective in breast, hereditary prostate, and pancreatic tumors. Association of CDNK1B mutations or polymorphisms with sporadic medullary thyroid carcinoma (MTC) has not been investigated yet. We screened germline DNA from 84 patients affected by sporadic MTC and 90 healthy age- and gender-matched controls for CDKN1B mutations or polymorphisms by PCR amplification and sequencing of the amplicons. We also tested all germline and 50 tumor tissue DNA for RET proto-oncogene mutations. Computed tomography, ultrasound scans, and serum calcitonin were carried out before surgery and during the follow-up and associated with CDKN1B polymorphism and disease remission. The T/G transversion at nucleotide 326 was the only DNA variation detected. The overall frequency of the T/G and G/G alleles in combination was 46.4%. This variant (V109G) was correlated with post-operative calcitonin levels in the normal range and biochemical remission. Conversely, the wild-type (T/T) allele was associated with post-operative calcitonin levels above normal and a higher risk to develop clinical recurrence and distant metastases. Somatic RET mutations were significantly associated with a more aggressive behavior especially in wild-type allele-bearing patients. Collectively, in sporadic MTC, the CDKN1B V109G polymorphism correlates with a more favorable disease progression than the wild-type allele and might be considered a new promising prognostic marker.

Published
2011

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