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1. Reduction of daily maintenance inhaled corticosteroids in patients with severe eosinophilic asthma treated with benralizumab (SHAMAL): a randomised, multicentre, open-label, phase 4 study

Author

Kroegel, Claus, Caruso, Cristiano, Baglivo, Ilaria, Colantuono, Stefania, Jackson, David, Skowasch, Dirk, Di Marco, Fabiano, Couturaud, Francis, Käßner, Frank, Cwiek, Iwona, Teber, Markus, Knetsch, Kornelia, Preuß, Jasmin, Devouassoux, Gilles, Milger-Kneidinger, Katrin, Heaney, Liam, Jerrentrup, Lukas, Humbert, Marc, Jandl, Margret, Timmermann, Hartmut, Probst, Beatrice, D'Amato, Maria, Hoffmann, Martin, Bonniaud, Philippe, Beltramo, Guillaume, Girodet, Pierre-Olivier, Berger, Patrick, Nasser, Shuaib, Fry, Stéphanie, Korn, Stephanie, Aries, Sven Philip, Koehler, Thomas, Harrison, Timothy, Jackson, David J, Heaney, Liam G, Kent, Brian D, Shavit, Anat, Hiljemark, Lina, Olinger, Lynda, Cohen, David, and Menzies-Gow, Andrew

Published
2024
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5. Severe asthma: One disease and multiple definitions

Author

Guarnieri, Gabriella, Patella, Vincenzo, Maria Pia, Foschino Barbaro, Carpagnano, Giovanna Elisiana, Colle, Anna del, Scioscia, Giulia, Gerolamo, Pelaia, Puggioni, Francesca, Racca, Francesca, Favero, Elisabetta, Iannacone, Sandra, Savi, Eleonora, Montagni, Marcello, Camiciottoli, Gianna, Allegrini, Chiara, Lombardi, Carlo, Spadaro, Giuseppe, Detoraki, Caterina, Menzella, Francesco, Galeone, Carla, Ruggiero, Patrizia, Yacoub, Monna Rita, Berti, Alvise, Scichilone, Nicola, Durante, Carmen, Costantino, Maria Teresa, Roncallo, Chiara, Braschi, Mariachiara, D’Adda, Alice, Ridolo, Erminia, Triggiani, Massimo, Parente, Roberta, Maria, D’Amato, Verrillo, Maria Vittoria, Rolla, Giovanni, Brussino, Luisa, Frazzetto, Agata Valentina, Cristina, Zappa Maria, Lilli, Marianna, Crimi, Nunzio, Bonavia, Marco, Corsico, Angelo Guido, Grosso, Amelia, Del Giacco, Stefano, Deidda, Margherita, Ricciardi, Luisa, Isola, Stefania, Cicero, Francesca, Amato, Giuliana, Vita, Federica, Spanevello, Antonio, Pignatti, Patrizia, Cherubino, Francesca, Visca, Dina, Massimo Ricciardolo, Fabio Luigi, Anna Carriero, Vitina Maria, Bertolini, Francesca, Santus, Pierachille, Barlassina, Roberta, Airoldi, Andrea, Guida, Giuseppe, Eleonora, Nucera, Aruanno, Arianna, Rizzi, Angela, Caruso, Cristiano, Colantuono, Stefania, Senna, Gianenrico, Caminati, Marco, Arcolaci, Alessandra, Vianello, Andrea, Bianchi, Fulvia Chieco, Marchi, Maria Rita, Centanni, Stefano, Luraschi, Simone, Ruggeri, Silvia, Rinaldo, Rocco, Parazzini, Elena, Calabrese, Cecilia, Flora, Martina, Cosmi, Lorenzo, Di Pietro, Linda, Maggi, Enrico, Pini, Laura, Macchia, Luigi, Di Bona, Danilo, Richeldi, Luca, Condoluci, Carola, Fuso, Leonello, Bonini, Matteo, Farsi, Alessandro, Carli, Giulia, Montuschi, Paolo, Santini, Giuseppe, Conte, Maria Elisabetta, Turchet, Elisa, Barbetta, Carlo, Mazza, Francesco, D’Alo, Simona, Pucci, Stefano, Caiaffa, Maria Filomena, Minenna, Elena, D'Elia, Luciana, Pasculli, Carlo, Viviano, Vittorio, Tarsia, Paolo, Rolo, Joyce, Di Proietto, Mariacarmela, Lo Cicero, Salvatore, Bagnasco, Diego, Paggiaro, Pierluigi, Latorre, Manuela, Folli, Chiara, Testino, Elisa, Bassi, Arianna, Milanese, Manlio, Heffler, Enrico, Manfredi, Andrea, Riccio, Anna Maria, De Ferrari, Laura, Blasi, Francesco, Canevari, Rikki Frank, Canonica, Giorgio Walter, and Passalacqua, Giovanni

Published
2021
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6. Reduction of daily maintenance inhaled corticosteroids in patients with severe eosinophilic asthma treated with benralizumab (SHAMAL): a randomised, multicentre, open-label, phase 4 study

Author

Jackson, David J, primary, Heaney, Liam G, additional, Humbert, Marc, additional, Kent, Brian D, additional, Shavit, Anat, additional, Hiljemark, Lina, additional, Olinger, Lynda, additional, Cohen, David, additional, Menzies-Gow, Andrew, additional, Korn, Stephanie, additional, Kroegel, Claus, additional, Caruso, Cristiano, additional, Baglivo, Ilaria, additional, Colantuono, Stefania, additional, Jackson, David, additional, Skowasch, Dirk, additional, Di Marco, Fabiano, additional, Couturaud, Francis, additional, Käßner, Frank, additional, Cwiek, Iwona, additional, Teber, Markus, additional, Knetsch, Kornelia, additional, Preuß, Jasmin, additional, Devouassoux, Gilles, additional, Milger-Kneidinger, Katrin, additional, Heaney, Liam, additional, Jerrentrup, Lukas, additional, Jandl, Margret, additional, Timmermann, Hartmut, additional, Probst, Beatrice, additional, D'Amato, Maria, additional, Hoffmann, Martin, additional, Bonniaud, Philippe, additional, Beltramo, Guillaume, additional, Girodet, Pierre-Olivier, additional, Berger, Patrick, additional, Nasser, Shuaib, additional, Fry, Stéphanie, additional, Aries, Sven Philip, additional, Koehler, Thomas, additional, and Harrison, Timothy, additional

Published
2024
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7. Economic impact of mepolizumab in uncontrolled severe eosinophilic asthma, in real life

Author

Guarnieri, Gabriella, Patella, Vincenzo, Maria Pia, Foschino Barbaro, Carpagnano, Elisiana, Colle, Anna del, Scioscia, Giulia, Gerolamo, Pelaia, Paggiaro, Pierluigi, Latorre, Manuela, Puggioni, Francesca, Racca, Francesca, Favero, Elisabetta, Iannacone, Sandra, Savi, Eleonora, Montagni, Marcello, Camiciottoli, Gianna, Allegrini, Chiara, Spadaro, Giuseppe, Detoraki, Caterina, Galeone, Carla, Ruggiero, Patrizia, Yacoub, Monna Rita, Berti, Alvise, Colombo, Gisella, Scichilone, Nicola, Durante, Carmen, Costantino, Maria Teresa, Roncallo, Chiara, Braschi, Mariachiara, Blasi, Francesco, D'Adda, Alice, Ridolo, Erminia, Triggiani, Massimo, Parente, Roberta, Maria, D'Amato, Verrillo, Maria Vittoria, Cristina, Zappa Maria, Lilli, Marianna, Crimi, Nunzio, Bonavia, Marco, Corsico, Angelo Guido, Grosso, Amelia, Del Giacco, Stefano, Deidda, Margherita, Ricciardi, Luisa, Isola, Stefania, Cicero, Francesca, Amato, Giuliana, Vita, Federica, Spanevello, Antonio, Pignatti, Patrizia, Cherubino, Francesca, Visca, Dina, Aletti, Eleonora, Massimo Ricciardolo, Fabio Luigi, Anna Carriero, Vitina Maria, Bertolini, Francesca, Santus, Pierachille, Barlassina, Roberta, Airoldi, Andrea, Guida, Giuseppe, Eleonora, Nucera, Aruanno, Arianna, Rizzi, Angela, Caruso, Cristiano, Colantuono, Stefania, Arcolaci, Alessandra, Vianello, Andrea, Bianchi, Fulvia Chieco, Marchi, Maria Rita, Centanni, Stefano, Luraschi, Simone, Ruggeri, Silvia, Rinaldo, Rocco, Parazzini, Elena, Calabrese, Cecilia, Flora, Martina, Cosmi, Lorenzo, Di Pietro, Linda, Maggi, Enrico, Pini, Laura, Macchia, Luigi, Di Bona, Danilo, Richeldi, Luca, Condoluci, Carola, Fuso, Leonello, Bonini, Matteo, Farsi, Alessandro, Carli, Giulia, Montuschi, Paolo, Santini, Giuseppe, Conte, Maria Elisabetta, Turchet, Elisa, Barbetta, Carlo, Mazza, Francesco, D'Alo, Simona, Pucci, Stefano, Caiaffa, Maria Filomena, Minenna, Elena, D'Elia, Luciana, Pasculli, Carlo, Viviano, Vittorio, Tarsia, Paolo, Rolo, Joyce, Di Proietto, Mariacarmela, Lo Cicero, Salvatore, Bagnasco, Diego, Povero, Massimiliano, Pradelli, Lorenzo, Brussino, Luisa, Rolla, Giovanni, Caminati, Marco, Menzella, Francesco, Heffler, Enrico, Canonica, Giorgio Walter, Senna, Gianenrico, Milanese, Manlio, Lombardi, Carlo, Bucca, Caterina, Manfredi, Andrea, Canevari, Rikki Frank, and Passalacqua, Giovanni

Published
2021
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8. Safety and effectiveness of biosimilar of Rituximab CT-P10 in the treatment of cryoglobulinemic vasculitis: the MARBLe study (Mixed cryoglobulinemiA Rituximab BiosimiLar)

Author

Vacchi, Caterina, Visentini, Marcella, Gragnani, Laura, Fraticelli, Paolo, Tavoni, Antonio, Filippini, Davide, Saccardo, Francesco, Lauletta, Gianfranco, Colantuono, Stefania, Atzeni, Fabiola, Pioltelli, Pietro, Manfredi, Andreina, Casato, Milvia, Zignego, Anna Linda, Monti, Giuseppe, Pietrogrande, Maurizio, Galli, Massimo, and Sebastiani, Marco

Published
2021
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11. Dual stimulation by autoantigen and CpG fosters the proliferation of exhausted rheumatoid factor-specific CD21low B cells in hepatitis C virus-cured mixed cryoglobulinemia.

Author

Del Padre, Martina, Marrapodi, Ramona, Minafò, Ylenia A., Mortari, Eva Piano, Radicchio, Giovanna, Bocci, Chiara, Gragnani, Laura, Camponeschi, Alessandro, Colantuono, Stefania, Stefanini, Lucia, Basili, Stefania, Carsetti, Rita, Fiorilli, Massimo, Casato, Milvia, and Visentini, Marcella

Subjects
B cells, B cell receptors, CRYOGLOBULINEMIA, HEPATITIS B, IMMUNE complexes, RHEUMATOID factor
Abstract

Introduction: Hepatitis C virus (HCV) causes mixed cryoglobulinemia (MC) by driving clonal expansion of B cells expressing B cell receptors (BCRs), often encoded by the VH1-69 variable gene, endowed with both rheumatoid factor (RF) and anti-HCV specificity. These cells display an atypical CD21low phenotype and functional exhaustion evidenced by unresponsiveness to BCR and Toll-like receptor 9 (TLR9) stimuli. Although antiviral therapy is effective on MC vasculitis, pathogenic B cell clones persist long thereafter and can cause virus-independent disease relapses. Methods: Clonal B cells from patients with HCV-associated type 2 MC or healthy donors were stimulated with CpG or heath-aggregated IgG (as surrogate immune complexes) alone or in combination; proliferation and differentiation were then evaluated by flow cytometry. Phosphorylation of AKT and of the p65 NF-kB subunit were measured by flow cytometry. TLR9 was quantified by qPCR and by intracellular flow cytometry, and MyD88 isoforms were analyzed using RT-PCR. Discussion: We found that dual triggering with autoantigen and CpG restored the capacity of exhausted VH1-69pos B cells to proliferate. The signaling mechanism for this BCR/TLR9 crosstalk remains elusive, since TLR9 mRNA and protein as well as MyD88 mRNA were normally expressed and CpG-induced phosphorylation of p65 NF-kB was intact in MC clonal B cells, whereas BCR-induced p65 NF-kB phosphorylation was impaired and PI3K/Akt signaling was intact. Our findings indicate that autoantigen and CpG of microbial or cellular origin may unite to foster persistence of pathogenic RF B cells in HCV-cured MC patients. BCR/TLR9 crosstalk might represent a more general mechanism enhancing systemic autoimmunity by the rescue of exhausted autoreactive CD21low B cells. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Immunoglobulin Free Light Chains in Severe Asthma Patient: could they be a new biomarker?

Author

Caruso, Cristiano, primary, Ciasca, Gabriele, additional, Baglivo, *, additional, Santo, Riccardo Di, additional, Gasbarrini, Antonio, additional, Firinu, Davide, additional, Bagnasco, Diego, additional, Passalacqua, Giovanni, additional, Schiappoli, Michele, additional, Caminati, Marco, additional, Canonica, Giorgio Walter, additional, Heffler, Enrico, additional, Crimi, Claudia, additional, Intravaia, Rossella, additional, V., Basile, additional, Marino, Mariapaola, additional, colantuono, stefania, additional, and Giacco, Stefano R. Del, additional

Published
2023
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13. Clinical research coordinators: Key components of an efficient clinical trial unit

Author

Mora, Vincenzina, primary, Colantuono, Stefania, additional, Fanali, Caterina, additional, Leonetti, Alessia, additional, Wlderk, Giulia, additional, Pirro, Maria Antonia, additional, Calà Palmarino, Francesca Maria, additional, Savini, Roberta, additional, Ianiro, Gianluca, additional, Gasbarrini, Antonio, additional, Celeste, Pirozzoli Maria, additional, Luciana, Giannone, additional, Cristina, Spataro, additional, Cristina, Graziani, additional, Anna, Capodrossi, additional, Anna, Teberino Maria, additional, Barbara, Tolusso, additional, Marica, Di Ciurcio, additional, Diana, Verdirosi, additional, Serena, Rotunno, additional, Ludovica, Finotti, additional, Laura, Turchini, additional, Valeria, Amatucci, additional, Elisa, Schiavoni, additional, Daniele, Napolitano, additional, Eleonora, Durini, additional, Martina, Strazzeri, additional, Teresa, Lombardi Maria, additional, and Elisabetta, Schifano, additional

Published
2023
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14. Dual stimulation by autoantigen and CpG fosters the proliferation of exhausted rheumatoid factor-specific CD21low B cells in hepatitis C virus-cured mixed cryoglobulinemia

Author

Del Padre, Martina, primary, Marrapodi, Ramona, additional, Minafò, Ylenia A., additional, Piano Mortari, Eva, additional, Radicchio, Giovanna, additional, Bocci, Chiara, additional, Gragnani, Laura, additional, Camponeschi, Alessandro, additional, Colantuono, Stefania, additional, Stefanini, Lucia, additional, Basili, Stefania, additional, Carsetti, Rita, additional, Fiorilli, Massimo, additional, Casato, Milvia, additional, and Visentini, Marcella, additional

Published
2023
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17. Clinical research coordinators: Key components of an efficient clinical trial unit

Author

Celeste, Pirozzoli Maria, Luciana, Giannone, Cristina, Spataro, Cristina, Graziani, Anna, Capodrossi, Anna, Teberino Maria, Barbara, Tolusso, Marica, Di Ciurcio, Diana, Verdirosi, Serena, Rotunno, Ludovica, Finotti, Laura, Turchini, Valeria, Amatucci, Elisa, Schiavoni, Daniele, Napolitano, Eleonora, Durini, Martina, Strazzeri, Teresa, Lombardi Maria, Elisabetta, Schifano, Mora, Vincenzina, Colantuono, Stefania, Fanali, Caterina, Leonetti, Alessia, Wlderk, Giulia, Pirro, Maria Antonia, Calà Palmarino, Francesca Maria, Savini, Roberta, Ianiro, Gianluca, and Gasbarrini, Antonio

Published
2023
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19. Different aspects of severe asthma in real life: Role of Staphylococcus aureus enterotoxins and correlation to comorbidities and disease severity

Author

Caruso, Cristiano, primary, Colantuono, Stefania, additional, Ciasca, Gabriele, additional, Basile, Umberto, additional, Di Santo, Riccardo, additional, Bagnasco, Diego, additional, Passalacqua, Giovanni, additional, Caminati, Marco, additional, Michele, Schiappoli, additional, Senna, Gianenrico, additional, Heffler, Enrico, additional, Canonica, G. Walter, additional, Crimi, Nunzio, additional, Intravaia, Rossella, additional, De Corso, Eugenio, additional, Firinu, Davide, additional, Gasbarrini, Antonio, additional, and Del Giacco, Stefano R., additional

Published
2022
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20. Different aspects of severe asthma in real life: Role of Staphylococcus aureus enterotoxins and correlation to comorbidities and disease severity.

Author

Caruso, Cristiano, Colantuono, Stefania, Ciasca, Gabriele, Basile, Umberto, Di Santo, Riccardo, Bagnasco, Diego, Passalacqua, Giovanni, Caminati, Marco, Michele, Schiappoli, Senna, Gianenrico, Heffler, Enrico, Canonica, G. Walter, Crimi, Nunzio, Intravaia, Rossella, De Corso, Eugenio, Firinu, Davide, Gasbarrini, Antonio, and Del Giacco, Stefano R.

Subjects
*STAPHYLOCOCCUS aureus, *ENTEROTOXINS, *ASTHMA, *FOOD poisoning, *NASAL polyps, *COMORBIDITY, *ATOPY
Abstract

Background: Asthma, with several phenotypes and endotypes, is considered particularly suited for precision medicine. The identification of different non‐invasive biomarkers may facilitate diagnosis and treatment. Recently, Staphylococcus aureus and its enterotoxins (SE) have been found to have a role in inducing persistent type 2 airway inflammation in severe asthma, but also in such comorbidities as chronic rhinosinusitis with nasal polyposis (CRSwNP). Methods: The aim of this retrospective study was to evaluate the prevalence of SE‐IgE sensitization in a multicentric Italian cohort of severe asthmatic patients and correlate it with demographic and clinical characteristics. Results: A total of 249 patients were included in the analysis, out of which 25.3% were staphylococcal enterotoxin B (SEB)‐IgE positive. We found a meaningful association between SEB‐IgE and female gender, a positive association was also measured between CRS and CRSwNP. No significant association was found between SEB‐IgE sensitization and atopy, the occurrence of exacerbations and corticosteroid dosages. In the SEB‐IgE‐positive patient, blood eosinophil count does not appear to be correlated with the severity of the disease. Patients with SEB‐IgE sensitization are, on average, younger and with an earlier disease onset, thus confirming the possibility to consider SEB‐IgE sensitization as an independent risk factor for developing asthma. Conclusions: Our data confirm that the search for SE in the initial screening phase of these patients is helpful to better phenotype them, may predict the evolution of comorbidities and lead to a targeted therapeutic choice; in this point of view this represents a goal of precision medicine. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Autoimmune hepatitis with eosinophilic infiltration responsive to anti-interleukin-5 receptor treatment: a case report and literature review.

Author

Ponziani, Francesca Romana, Caruso, Cristiano, Baglivo, Ilaria, Macagno, Francesco, Gasbarrini, Antonio, Santopaolo, Francesco, Giustiniani, Maria Cristina, Colantuono, Stefania, and Pompili, Maurizio

Abstract

Inflammatory tissue damage plays a role in the onset, progression, and exacerbation of various chronic autoimmune and metabolic diseases such as autoimmune hepatitis. Here we present a case of autoimmune hepatitis with liver eosinophilic infiltrate in a severe eosinophilic asthma patient who failed conventional immunosuppressive treatment and showed improvement in gastrointestinal symptoms after anti-interleukin-5 receptor treatment. Our case highlights the potential role of eosinophils in initiating or worsening liver inflammation in autoimmune liver disease. The link between eosinophilic inflammation, barrier damage, and chronic autoimmune diseases should be considered in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Severe asthma: One disease and multiple definitions

Author

Bagnasco, Diego, primary, Paggiaro, Pierluigi, additional, Latorre, Manuela, additional, Folli, Chiara, additional, Testino, Elisa, additional, Bassi, Arianna, additional, Milanese, Manlio, additional, Heffler, Enrico, additional, Manfredi, Andrea, additional, Riccio, Anna Maria, additional, De Ferrari, Laura, additional, Blasi, Francesco, additional, Canevari, Rikki Frank, additional, Canonica, Giorgio Walter, additional, Passalacqua, Giovanni, additional, Guarnieri, Gabriella, additional, Patella, Vincenzo, additional, Maria Pia, Foschino Barbaro, additional, Carpagnano, Giovanna Elisiana, additional, Colle, Anna del, additional, Scioscia, Giulia, additional, Gerolamo, Pelaia, additional, Puggioni, Francesca, additional, Racca, Francesca, additional, Favero, Elisabetta, additional, Iannacone, Sandra, additional, Savi, Eleonora, additional, Montagni, Marcello, additional, Camiciottoli, Gianna, additional, Allegrini, Chiara, additional, Lombardi, Carlo, additional, Spadaro, Giuseppe, additional, Detoraki, Caterina, additional, Menzella, Francesco, additional, Galeone, Carla, additional, Ruggiero, Patrizia, additional, Yacoub, Monna Rita, additional, Berti, Alvise, additional, Scichilone, Nicola, additional, Durante, Carmen, additional, Costantino, Maria Teresa, additional, Roncallo, Chiara, additional, Braschi, Mariachiara, additional, D’Adda, Alice, additional, Ridolo, Erminia, additional, Triggiani, Massimo, additional, Parente, Roberta, additional, Maria, D’Amato, additional, Verrillo, Maria Vittoria, additional, Rolla, Giovanni, additional, Brussino, Luisa, additional, Frazzetto, Agata Valentina, additional, Cristina, Zappa Maria, additional, Lilli, Marianna, additional, Crimi, Nunzio, additional, Bonavia, Marco, additional, Corsico, Angelo Guido, additional, Grosso, Amelia, additional, Del Giacco, Stefano, additional, Deidda, Margherita, additional, Ricciardi, Luisa, additional, Isola, Stefania, additional, Cicero, Francesca, additional, Amato, Giuliana, additional, Vita, Federica, additional, Spanevello, Antonio, additional, Pignatti, Patrizia, additional, Cherubino, Francesca, additional, Visca, Dina, additional, Massimo Ricciardolo, Fabio Luigi, additional, Anna Carriero, Vitina Maria, additional, Bertolini, Francesca, additional, Santus, Pierachille, additional, Barlassina, Roberta, additional, Airoldi, Andrea, additional, Guida, Giuseppe, additional, Eleonora, Nucera, additional, Aruanno, Arianna, additional, Rizzi, Angela, additional, Caruso, Cristiano, additional, Colantuono, Stefania, additional, Senna, Gianenrico, additional, Caminati, Marco, additional, Arcolaci, Alessandra, additional, Vianello, Andrea, additional, Bianchi, Fulvia Chieco, additional, Marchi, Maria Rita, additional, Centanni, Stefano, additional, Luraschi, Simone, additional, Ruggeri, Silvia, additional, Rinaldo, Rocco, additional, Parazzini, Elena, additional, Calabrese, Cecilia, additional, Flora, Martina, additional, Cosmi, Lorenzo, additional, Di Pietro, Linda, additional, Maggi, Enrico, additional, Pini, Laura, additional, Macchia, Luigi, additional, Di Bona, Danilo, additional, Richeldi, Luca, additional, Condoluci, Carola, additional, Fuso, Leonello, additional, Bonini, Matteo, additional, Farsi, Alessandro, additional, Carli, Giulia, additional, Montuschi, Paolo, additional, Santini, Giuseppe, additional, Conte, Maria Elisabetta, additional, Turchet, Elisa, additional, Barbetta, Carlo, additional, Mazza, Francesco, additional, D’Alo, Simona, additional, Pucci, Stefano, additional, Caiaffa, Maria Filomena, additional, Minenna, Elena, additional, D'Elia, Luciana, additional, Pasculli, Carlo, additional, Viviano, Vittorio, additional, Tarsia, Paolo, additional, Rolo, Joyce, additional, Di Proietto, Mariacarmela, additional, and Lo Cicero, Salvatore, additional

Published
2021
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26. β-Lactam Allergy and Cross-Reactivity: A Clinician’s Guide to Selecting an Alternative Antibiotic

Author

Caruso,Cristiano, Valluzzi,Rocco Luigi, Colantuono,Stefania, Gaeta,Francesco, and Romano,Antonino

Subjects
polycyclic compounds, Journal of Asthma and Allergy, biochemical phenomena, metabolism, and nutrition
Abstract

Cristiano Caruso,1 Rocco Luigi Valluzzi,2 Stefania Colantuono,1 Francesco Gaeta,1 Antonino Romano3,4 1Allergy Unit, Columbus Hospital, Fondazione Policlinico A. Gemelli, IRCCS, Rome, Italy; 2Department of Pediatrics, Division of Allergy, Pediatric Hospital Bambino Gesù, Rome, Vatican City, Italy; 3Oasi Research Institute-IRCCS, Troina, Italy; 4Fondazione Mediterranea G.B. Morgagni, Catania, ItalyCorrespondence: Cristiano Caruso Tel +393348079133Email cristiano.caruso@policlinicogemelli.itAbstract: β-Lactams which include penicillins, cephalosporins, carbapenems, and monobactams are the most common antibiotic classes reported to cause allergic reactions to drugs. This review is mainly about published studies assessing the cross-reactivity among β-lactams in penicillin- or cephalosporin-allergic subjects by carrying out diagnostic tests with alternative β-lactams and, if appropriate, graded challenges. Several studies demonstrated that cross-reactivity connected with the β-lactam ring, causing positive responses to allergy tests with all β-lactams, is infrequent in subjects with an IgE-mediated allergy and anecdotal in those with a T-cell-mediated allergy. Identities or similarities of β-lactam side-chain structures are mainly responsible for cross-reactivity among these antibiotics. For example, in aminopenicillin-allergic subjects, cross-reactivity with aminocephalosporins could possibly be over 30%. On the other hand, in a few prospective studies of penicillin-allergic individuals, less than 1% of cases show a cross-reactivity between penicillins and both aztreonam and carbapenems. Particular patterns of allergy-test positivity observed in some studies that assessed cross-reactivity among β-lactams seem to indicate that prior exposures may be responsible for coexisting sensitivities. Therefore, pre-treatment skin tests with the related β-lactams are suggested before administering them via graded challenges to β-lactam-allergic patients who need alternative β-lactams.Keywords: aztreonam, β-lactams, carbapenems, cephalosporins, cross-reactivity, hypersensitivity, penicillins, skin tests

Published
2021

28. Cryoglobulins: putative effectors of adaptive immune response

Author

Basile, Umberto, primary, Napodano, Cecilia, additional, Marino, Mariapaola, additional, Gulli, Francesca, additional, Colantuono, Stefania, additional, Casato, Milvia, additional, Pocino, Krizia, additional, Basile, Valerio, additional, Todi, Laura, additional, Rapaccini, Gian Ludovico, additional, and Visentini, Marcella, additional

Published
2021
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29. Real-life survey on severe asthma patients during COVID-19 lockdown in Italy

Author

Caruso, Cristiano, primary, Colantuono, Stefania, additional, Urbani, Sara, additional, Heffler, Enrico, additional, Canonica, Giorgio Walter, additional, Andriollo, Gloria, additional, Di Michele, Loreta, additional, Scarlata, Simone, additional, Zennaro, Danila, additional, Rigon, Amelia, additional, Vadacca, Marta, additional, Moroni, Rossana, additional, Nucera, Eleonora, additional, and Gasbarrini, Antonio, additional

Published
2021
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30. Mutational and immunogenetic landscape of HCV ‐associated B‐cell lymphoproliferative disorders

Author

Defrancesco, Irene, primary, Visentini, Marcella, additional, Zibellini, Silvia, additional, Minafò, Ylenia Aura, additional, Rattotti, Sara, additional, Ferretti, Virginia Valeria, additional, Rizzo, Ettore, additional, Varettoni, Marzia, additional, Frigeni, Marco, additional, Pulsoni, Alessandro, additional, Casato, Milvia, additional, Colantuono, Stefania, additional, Rossi, Marianna, additional, Candido, Chiara, additional, Zerbi, Caterina, additional, Bergamini, Fabio, additional, Cristinelli, Caterina, additional, Fabbri, Nicole, additional, Merli, Michele, additional, Zuccaro, Valentina, additional, Bruno, Raffaele, additional, Paulli, Marco, additional, and Arcaini, Luca, additional

Published
2021
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31. Solving the mystery of HBV-related mixed cryoglobulinemia: potential biomarkers of disease progression

Author

Pocino, Krizia, primary, Napodano, Cecilia, additional, Gragnani, Laura, additional, Ciasca, Gabriele, additional, Colantuono, Stefania , additional, Marri, Silvia, additional, Vantaggio, Lorenzo, additional, Gulli, Francesca, additional, Lorini, Serena, additional, Barini, Antonella, additional, Stefanile, Annunziata, additional, Miele, Luca, additional, Casato, Milvia, additional, Zignego, Anna Linda, additional, Rapaccini, Gian Ludovico, additional, Marino, Mariapaola, additional, Visentini, Marcella, additional, and Basile, Umberto, additional

Published
2021
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32. Economic impact of mepolizumab in uncontrolled severe eosinophilic asthma, in real life

Author

Bagnasco, Diego, primary, Povero, Massimiliano, additional, Pradelli, Lorenzo, additional, Brussino, Luisa, additional, Rolla, Giovanni, additional, Caminati, Marco, additional, Menzella, Francesco, additional, Heffler, Enrico, additional, Canonica, Giorgio Walter, additional, Paggiaro, Pierluigi, additional, Senna, Gianenrico, additional, Milanese, Manlio, additional, Lombardi, Carlo, additional, Bucca, Caterina, additional, Manfredi, Andrea, additional, Canevari, Rikki Frank, additional, Passalacqua, Giovanni, additional, Guarnieri, Gabriella, additional, Patella, Vincenzo, additional, Maria Pia, Foschino Barbaro, additional, Carpagnano, Elisiana, additional, Colle, Anna del, additional, Scioscia, Giulia, additional, Gerolamo, Pelaia, additional, Latorre, Manuela, additional, Puggioni, Francesca, additional, Racca, Francesca, additional, Favero, Elisabetta, additional, Iannacone, Sandra, additional, Savi, Eleonora, additional, Montagni, Marcello, additional, Camiciottoli, Gianna, additional, Allegrini, Chiara, additional, Spadaro, Giuseppe, additional, Detoraki, Caterina, additional, Galeone, Carla, additional, Ruggiero, Patrizia, additional, Yacoub, Monna Rita, additional, Berti, Alvise, additional, Colombo, Gisella, additional, Scichilone, Nicola, additional, Durante, Carmen, additional, Costantino, Maria Teresa, additional, Roncallo, Chiara, additional, Braschi, Mariachiara, additional, Blasi, Francesco, additional, D'Adda, Alice, additional, Ridolo, Erminia, additional, Triggiani, Massimo, additional, Parente, Roberta, additional, Maria, D'Amato, additional, Verrillo, Maria Vittoria, additional, Cristina, Zappa Maria, additional, Lilli, Marianna, additional, Crimi, Nunzio, additional, Bonavia, Marco, additional, Corsico, Angelo Guido, additional, Grosso, Amelia, additional, Del Giacco, Stefano, additional, Deidda, Margherita, additional, Ricciardi, Luisa, additional, Isola, Stefania, additional, Cicero, Francesca, additional, Amato, Giuliana, additional, Vita, Federica, additional, Spanevello, Antonio, additional, Pignatti, Patrizia, additional, Cherubino, Francesca, additional, Visca, Dina, additional, Aletti, Eleonora, additional, Massimo Ricciardolo, Fabio Luigi, additional, Anna Carriero, Vitina Maria, additional, Bertolini, Francesca, additional, Santus, Pierachille, additional, Barlassina, Roberta, additional, Airoldi, Andrea, additional, Guida, Giuseppe, additional, Eleonora, Nucera, additional, Aruanno, Arianna, additional, Rizzi, Angela, additional, Caruso, Cristiano, additional, Colantuono, Stefania, additional, Arcolaci, Alessandra, additional, Vianello, Andrea, additional, Bianchi, Fulvia Chieco, additional, Marchi, Maria Rita, additional, Centanni, Stefano, additional, Luraschi, Simone, additional, Ruggeri, Silvia, additional, Rinaldo, Rocco, additional, Parazzini, Elena, additional, Calabrese, Cecilia, additional, Flora, Martina, additional, Cosmi, Lorenzo, additional, Di Pietro, Linda, additional, Maggi, Enrico, additional, Pini, Laura, additional, Macchia, Luigi, additional, Di Bona, Danilo, additional, Richeldi, Luca, additional, Condoluci, Carola, additional, Fuso, Leonello, additional, Bonini, Matteo, additional, Farsi, Alessandro, additional, Carli, Giulia, additional, Montuschi, Paolo, additional, Santini, Giuseppe, additional, Conte, Maria Elisabetta, additional, Turchet, Elisa, additional, Barbetta, Carlo, additional, Mazza, Francesco, additional, D'Alo, Simona, additional, Pucci, Stefano, additional, Caiaffa, Maria Filomena, additional, Minenna, Elena, additional, D'Elia, Luciana, additional, Pasculli, Carlo, additional, Viviano, Vittorio, additional, Tarsia, Paolo, additional, Rolo, Joyce, additional, Di Proietto, Mariacarmela, additional, and Lo Cicero, Salvatore, additional

Published
2021
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34. Clinico‐immunological outcomes of HCV‐cured cryoglobulinemia: Lower relapse rate with interferon‐based than interferon‐free therapy

Author

Colantuono, Stefania, primary, Marrapodi, Ramona, additional, Del Padre, Martina, additional, Collalti, Giulia, additional, Garzi, Giulia, additional, De Santis, Adriano, additional, Fiorilli, Massimo, additional, Basili, Stefania, additional, Visentini, Marcella, additional, and Casato, Milvia, additional

Published
2020
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37. Safety and effectiveness of biosimilar of Rituximab CT-P10 in the treatment of cryoglobulinemic vasculitis: the MARBLe study (Mixed cryoglobulinemiA Rituximab BiosimiLar)

Author

Vacchi, Caterina, primary, Visentini, Marcella, additional, Gragnani, Laura, additional, Fraticelli, Paolo, additional, Tavoni, Antonio, additional, Filippini, Davide, additional, Saccardo, Francesco, additional, Lauletta, Gianfranco, additional, Colantuono, Stefania, additional, Atzeni, Fabiola, additional, Pioltelli, Pietro, additional, Manfredi, Andreina, additional, Casato, Milvia, additional, Zignego, Anna Linda, additional, Monti, Giuseppe, additional, Pietrogrande, Maurizio, additional, Galli, Massimo, additional, and Sebastiani, Marco, additional

Published
2020
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40. Prospective Italian real‐world study of mepolizumab in severe eosinophilic asthma validates retrospective outcome reports.

Author

Pini, Laura, Caruso, Cristiano, Colantuono, Stefania, Bagnasco, Diego, Maxwell, Aoife, Price, Robert G., Howarth, Peter, and Canonica, Giorgio Walter

Subjects
ASTHMA, MEDICAL personnel, PHYSICIANS, EOSINOPHILIA, EOSINOPHILIC granuloma, NEGATIVE binomial distribution
Abstract

Prospective Italian real-world study of mepolizumab in severe eosinophilic asthma validates retrospective outcome reports Current asthma guidelines inform about evidence-based approaches to optimize patient outcomes. Notably, the severity of asthma experienced by patients in both studies was very similar, and additionally patients had similar annual exacerbation rates (3.48 vs. 4.09 exacerbations/year) and similar hospitalization rates (0.44/year vs. 0.39/year). [Extracted from the article]

Published
2021
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41. Immunobiology of essential mixed cryoglobulinemia

Author

Colantuono, Stefania

Subjects
B cells, Essential mixed cryoglobulinemia, CD21low B cells, Essential mixed cryoglobulinemia, B cells, CD21low B cells, rheumatoid factor, rheumatoid factor
Published
2019

42. CD21low B cells are predictive markers of new digital ulcers in systemic sclerosis.

Author

Visentini, Marcella, Pellicano, Chiara, Leodori, Giorgia, Marrapodi, Ramona, Colantuono, Stefania, Gigante, Antonietta, Casato, Milvia, and Rosato, Edoardo

Subjects
B cells, SYSTEMIC scleroderma, ULCERS, BLOOD cells, RAYNAUD'S disease
Abstract

Summary: The objective of this study was to evaluate the predictive role of CD21low B cells as markers of new digital ulcers in systemic sclerosis patients. Peripheral blood B cell subpopulations and clinical assessments have been evaluated in 74 systemic sclerosis patients at baseline and after a 12‐month follow‐up. After a 12‐month follow‐up, 23 (31.1%) systemic sclerosis patients developed new digital ulcers. The median percentage of CD21low B cells was significantly higher in patients with than without new digital ulcers [10.1 (4.3–13.6) versus 4.8 (3.5–7.4); p < 0.01]. The 10% cut‐off shows good diagnostic accuracy [area under the curve (AUC) = 0.732, confidence interval (CI) = 0.587–0.878; P = 0.01]. Kaplan–Meier curves show a significantly reduced free survival from new digital ulcers in systemic sclerosis patients with CD21low B cells ≥ 10% (p < 0.0001). In multivariate analysis, CD21low B cells ≥ 10%, modified Rodnan skin score (mRSS) and systolic pulmonary arterial pressure (sPAP) are associated with the development of new digital ulcers. We hypothesize that CD21low B cells are a predictive marker of new digital ulcers in systemic sclerosis patients. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Biomarkers of minimal residual disease in rituximab-treated patients with mixed cryoglobulinemia.

Author

Basile, Umberto, Gulli, Francesca, Napodano, Cecilia, Pocino, Krizia, Basile, Valerio, Marrapodi, Ramona, Colantuono, Stefania, Todi, Laura, Marino, Mariapaola, Rapaccini, Gian Ludovico, and Visentini, Marcella

Subjects
RITUXIMAB, IMMUNOGLOBULIN M, VASCULAR endothelial growth factors, CRYOGLOBULINEMIA, NON-Hodgkin's lymphoma, BIOMARKERS, ENZYME-linked immunosorbent assay
Abstract

Hepatitis C virus (HCV) represents the major risk factor for mixed cryoglobulinemia (MC), a small-vessel vasculitis that may evolve into an overt B-cell non-Hodgkin's lymphoma. Here, we aimed to identify a biomarker signature for the early diagnosis of minimal residual disease (MRD). We assessed free light chains (FLCs), IgM k,and IgM λ heavy/light chain (HLC) pairs, and vascular endothelial growth factor (VEGF) in sera from 34 patients with MC vasculitis (32 HCV- and 2 HBV-related), treated with low-dose rituximab (RTX). FLCs and IgM HLCs were measured by turbidimetric assay; VEGF by an enzyme-linked immunosorbent assay. After RTX, the positive (complete + partial) clinical and laboratory responses were of 85.29% and 50%, respectively; in contrast, the mean levels of FLCs, IgM HLCs, and VEGF were substantially unaffected in most patients and still above the normal range. In those achieving a reduction of FLCs and IgM k and λ chains values within the range of normality, we found that post-treatment free λ chains and IgM k values correlated with clinical and laboratory response. Our results suggest that high levels of FLCs, IgM HLCs, and VEGF could represent the signature of "dormant" B cell clones' activity that could be very useful to identify MRD indicative of possible relapse or worsening outcome. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Long‐lasting persistence of large B‐cell clones in hepatitis C virus‐cured patients with complete response of mixed cryoglobulinaemia vasculitis

Author

Visentini, Marcella, primary, Del Padre, Martina, additional, Colantuono, Stefania, additional, Yang, Baoran, additional, Minafò, Ylenia Aura, additional, Antonini, Silvia, additional, Carnovale, Myriam, additional, De Santis, Adriano, additional, Pulsoni, Alessandro, additional, De Sanctis, Giuseppe Maria, additional, Gragnani, Laura, additional, Zignego, Anna Linda, additional, Fiorilli, Massimo, additional, and Casato, Milvia, additional

Published
2019
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46. Clinico‐immunological outcomes of HCV‐cured cryoglobulinemia: Lower relapse rate with interferon‐based than interferon‐free therapy.

Author

Colantuono, Stefania, Marrapodi, Ramona, Del Padre, Martina, Collalti, Giulia, Garzi, Giulia, De Santis, Adriano, Fiorilli, Massimo, Basili, Stefania, Visentini, Marcella, and Casato, Milvia

Subjects
*CRYOGLOBULINEMIA, *ANTIVIRAL agents, *HEPATITIS C virus, *INTERFERONS
Abstract

Sustained virological response (SVR) obtained with interferon (IFN) or with direct‐acting antivirals (DAAs) is commonly followed by response of hepatitis C virus (HCV)‐associated mixed cryoglobulinemia vasculitis (MCV), but relapse of MCV despite SVR has been reported in several patients after DAAs and rarely after IFN. Since relapses could have been overlooked in studies with IFN, we retrospectively compared the outcomes of MCV in SVR patients treated with DAAs (n = 70) or IFN (n = 39) followed‐up, respectively, for 30.5 (range 11‐51) or 48 months. Groups were comparable for demographics and clinics and response rates of MCV were similar (92% and 86%); however, DAA‐treated patients less efficiently reduced cryoglobulins (P =.006) and circulating B‐cell clones (P =.004), and had more frequently relapses of MCV (18% vs 3%, P =.028) and need for rituximab therapy (P =.01). Although largely inferior on an intention‐to‐treat basis, IFN may be superior to DAAs on clinico‐immunological outcomes possibly owing to its antiproliferative activity. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Prospective study of guideline-tailored therapy with direct-acting antivirals for hepatitis C virus-associated mixed cryoglobulinemia

Author

Gragnani, Laura, Visentini, Marcella, Fognani, Elisa, Urraro, Teresa, DE SANTIS, Adriano, Petraccia, Luisa, Perez, Marie, Ceccotti, Giorgia, Colantuono, Stefania, Mitrevski, Milica, Stasi, Cristina, Del Padre, Martina, Monti, Monica, Gianni, Elena, Pulsoni, Alessandro, Fiorilli, Massimo, Casato, Milvia, and Zignego, Anna Linda

Subjects
hepacivirus, hepatology, cryoglobulinemic vasculitis, cryoglobulinemia
Published
2016

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