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1. Reduction of daily maintenance inhaled corticosteroids in patients with severe eosinophilic asthma treated with benralizumab (SHAMAL): a randomised, multicentre, open-label, phase 4 study

Author

Kroegel, Claus, Caruso, Cristiano, Baglivo, Ilaria, Colantuono, Stefania, Jackson, David, Skowasch, Dirk, Di Marco, Fabiano, Couturaud, Francis, Käßner, Frank, Cwiek, Iwona, Teber, Markus, Knetsch, Kornelia, Preuß, Jasmin, Devouassoux, Gilles, Milger-Kneidinger, Katrin, Heaney, Liam, Jerrentrup, Lukas, Humbert, Marc, Jandl, Margret, Timmermann, Hartmut, Probst, Beatrice, D'Amato, Maria, Hoffmann, Martin, Bonniaud, Philippe, Beltramo, Guillaume, Girodet, Pierre-Olivier, Berger, Patrick, Nasser, Shuaib, Fry, Stéphanie, Korn, Stephanie, Aries, Sven Philip, Koehler, Thomas, Harrison, Timothy, Jackson, David J, Heaney, Liam G, Kent, Brian D, Shavit, Anat, Hiljemark, Lina, Olinger, Lynda, Cohen, David, and Menzies-Gow, Andrew

Published
2024
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4. Severe asthma: One disease and multiple definitions

Author

Guarnieri, Gabriella, Patella, Vincenzo, Maria Pia, Foschino Barbaro, Carpagnano, Giovanna Elisiana, Colle, Anna del, Scioscia, Giulia, Gerolamo, Pelaia, Puggioni, Francesca, Racca, Francesca, Favero, Elisabetta, Iannacone, Sandra, Savi, Eleonora, Montagni, Marcello, Camiciottoli, Gianna, Allegrini, Chiara, Lombardi, Carlo, Spadaro, Giuseppe, Detoraki, Caterina, Menzella, Francesco, Galeone, Carla, Ruggiero, Patrizia, Yacoub, Monna Rita, Berti, Alvise, Scichilone, Nicola, Durante, Carmen, Costantino, Maria Teresa, Roncallo, Chiara, Braschi, Mariachiara, D’Adda, Alice, Ridolo, Erminia, Triggiani, Massimo, Parente, Roberta, Maria, D’Amato, Verrillo, Maria Vittoria, Rolla, Giovanni, Brussino, Luisa, Frazzetto, Agata Valentina, Cristina, Zappa Maria, Lilli, Marianna, Crimi, Nunzio, Bonavia, Marco, Corsico, Angelo Guido, Grosso, Amelia, Del Giacco, Stefano, Deidda, Margherita, Ricciardi, Luisa, Isola, Stefania, Cicero, Francesca, Amato, Giuliana, Vita, Federica, Spanevello, Antonio, Pignatti, Patrizia, Cherubino, Francesca, Visca, Dina, Massimo Ricciardolo, Fabio Luigi, Anna Carriero, Vitina Maria, Bertolini, Francesca, Santus, Pierachille, Barlassina, Roberta, Airoldi, Andrea, Guida, Giuseppe, Eleonora, Nucera, Aruanno, Arianna, Rizzi, Angela, Caruso, Cristiano, Colantuono, Stefania, Senna, Gianenrico, Caminati, Marco, Arcolaci, Alessandra, Vianello, Andrea, Bianchi, Fulvia Chieco, Marchi, Maria Rita, Centanni, Stefano, Luraschi, Simone, Ruggeri, Silvia, Rinaldo, Rocco, Parazzini, Elena, Calabrese, Cecilia, Flora, Martina, Cosmi, Lorenzo, Di Pietro, Linda, Maggi, Enrico, Pini, Laura, Macchia, Luigi, Di Bona, Danilo, Richeldi, Luca, Condoluci, Carola, Fuso, Leonello, Bonini, Matteo, Farsi, Alessandro, Carli, Giulia, Montuschi, Paolo, Santini, Giuseppe, Conte, Maria Elisabetta, Turchet, Elisa, Barbetta, Carlo, Mazza, Francesco, D’Alo, Simona, Pucci, Stefano, Caiaffa, Maria Filomena, Minenna, Elena, D'Elia, Luciana, Pasculli, Carlo, Viviano, Vittorio, Tarsia, Paolo, Rolo, Joyce, Di Proietto, Mariacarmela, Lo Cicero, Salvatore, Bagnasco, Diego, Paggiaro, Pierluigi, Latorre, Manuela, Folli, Chiara, Testino, Elisa, Bassi, Arianna, Milanese, Manlio, Heffler, Enrico, Manfredi, Andrea, Riccio, Anna Maria, De Ferrari, Laura, Blasi, Francesco, Canevari, Rikki Frank, Canonica, Giorgio Walter, and Passalacqua, Giovanni

Published
2021
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5. Economic impact of mepolizumab in uncontrolled severe eosinophilic asthma, in real life

Author

Guarnieri, Gabriella, Patella, Vincenzo, Maria Pia, Foschino Barbaro, Carpagnano, Elisiana, Colle, Anna del, Scioscia, Giulia, Gerolamo, Pelaia, Paggiaro, Pierluigi, Latorre, Manuela, Puggioni, Francesca, Racca, Francesca, Favero, Elisabetta, Iannacone, Sandra, Savi, Eleonora, Montagni, Marcello, Camiciottoli, Gianna, Allegrini, Chiara, Spadaro, Giuseppe, Detoraki, Caterina, Galeone, Carla, Ruggiero, Patrizia, Yacoub, Monna Rita, Berti, Alvise, Colombo, Gisella, Scichilone, Nicola, Durante, Carmen, Costantino, Maria Teresa, Roncallo, Chiara, Braschi, Mariachiara, Blasi, Francesco, D'Adda, Alice, Ridolo, Erminia, Triggiani, Massimo, Parente, Roberta, Maria, D'Amato, Verrillo, Maria Vittoria, Cristina, Zappa Maria, Lilli, Marianna, Crimi, Nunzio, Bonavia, Marco, Corsico, Angelo Guido, Grosso, Amelia, Del Giacco, Stefano, Deidda, Margherita, Ricciardi, Luisa, Isola, Stefania, Cicero, Francesca, Amato, Giuliana, Vita, Federica, Spanevello, Antonio, Pignatti, Patrizia, Cherubino, Francesca, Visca, Dina, Aletti, Eleonora, Massimo Ricciardolo, Fabio Luigi, Anna Carriero, Vitina Maria, Bertolini, Francesca, Santus, Pierachille, Barlassina, Roberta, Airoldi, Andrea, Guida, Giuseppe, Eleonora, Nucera, Aruanno, Arianna, Rizzi, Angela, Caruso, Cristiano, Colantuono, Stefania, Arcolaci, Alessandra, Vianello, Andrea, Bianchi, Fulvia Chieco, Marchi, Maria Rita, Centanni, Stefano, Luraschi, Simone, Ruggeri, Silvia, Rinaldo, Rocco, Parazzini, Elena, Calabrese, Cecilia, Flora, Martina, Cosmi, Lorenzo, Di Pietro, Linda, Maggi, Enrico, Pini, Laura, Macchia, Luigi, Di Bona, Danilo, Richeldi, Luca, Condoluci, Carola, Fuso, Leonello, Bonini, Matteo, Farsi, Alessandro, Carli, Giulia, Montuschi, Paolo, Santini, Giuseppe, Conte, Maria Elisabetta, Turchet, Elisa, Barbetta, Carlo, Mazza, Francesco, D'Alo, Simona, Pucci, Stefano, Caiaffa, Maria Filomena, Minenna, Elena, D'Elia, Luciana, Pasculli, Carlo, Viviano, Vittorio, Tarsia, Paolo, Rolo, Joyce, Di Proietto, Mariacarmela, Lo Cicero, Salvatore, Bagnasco, Diego, Povero, Massimiliano, Pradelli, Lorenzo, Brussino, Luisa, Rolla, Giovanni, Caminati, Marco, Menzella, Francesco, Heffler, Enrico, Canonica, Giorgio Walter, Senna, Gianenrico, Milanese, Manlio, Lombardi, Carlo, Bucca, Caterina, Manfredi, Andrea, Canevari, Rikki Frank, and Passalacqua, Giovanni

Published
2021
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6. Immunoglobulin free light chains in severe asthma patient: Could they be a new biomarker?

Author

Caruso, Cristiano, Ciasca, Gabriele, Baglivo, I, Di&nbsp, Santo, R, Gasbarrini, Antonio, Firinu, D, Bagnasco, D., Passalacqua, G., Schiappoli, M., Caminati, M., Canonica, Gw, Heffler, E, Crimi, C, Intravaia, R, Basile, V, Marino, Mariapaola, Colantuono, Stefania, Del&nbsp, Giacco, S, Caruso, C, Ciasca, G (ORCID:0000-0002-3694-8229), Gasbarrini, A (ORCID:0000-0002-7278-4823), Marino, M (ORCID:0000-0001-9155-6378), Colantuono, S, Caruso, Cristiano, Ciasca, Gabriele, Baglivo, I, Di&nbsp, Santo, R, Gasbarrini, Antonio, Firinu, D, Bagnasco, D., Passalacqua, G., Schiappoli, M., Caminati, M., Canonica, Gw, Heffler, E, Crimi, C, Intravaia, R, Basile, V, Marino, Mariapaola, Colantuono, Stefania, Del&nbsp, Giacco, S, Caruso, C, Ciasca, G (ORCID:0000-0002-3694-8229), Gasbarrini, A (ORCID:0000-0002-7278-4823), Marino, M (ORCID:0000-0001-9155-6378), and Colantuono, S

Abstract

BackgroundIncreasing evidence is available about the presence of increased serum concentration of immunoglobulin (Ig) free light chains (FLCs) in both atopic and non-atopic inflammatory diseases, including severe asthma, providing a possible new biomarker of disease.MethodsWe analyzed clinical and laboratory data, including FLCs, obtained from a cohort of 79 asthmatic subjects, clinically classified into different GINA steps. A control group of 40 age-matched healthy donors (HD) was considered. Particularly, HD have been selected according to the absence of monoclonal components (in order to exclude paraproteinemias), were tested for total IgE (that were in the normal ranges) and were negative for aeroallergens specific IgE. Moreover, no abnormality of common inflammatory markers (i.e., erythrocyte sedimentation rate and C-reactive protein) was detectable.ResultsFLC-k levels were significantly increased in the asthmatic population, compared to the control group. Despite the absence of statistically significant differences in FLC-lambda levels, the FLC-k/FLC-lambda ratio displayed remarkable differences between the two groups. A positive correlation between FLC-kappa and FLC-lambda levels was found. FLC- lambda level displayed a significant negative correlation with the FEV1 value. Moreover, the FLC-kappa /FLC- lambda ratio was negatively correlated with the SNOT-22 score and a positive correlation was observed between FLCs and Staphylococcus Aureus IgE enterotoxins sensitization.ConclusionsOur findings confirmed the role of FLCs in asthma as a potential biomarker in an inflammatory disease characterized by different endotypes and phenotypes. In particular, FLC-kappa and FLC-k/FLC-lambda ratio could be a qualitative indicator for asthma, while FLC-lambda levels could be a quantitative indicator for clinical severity parameters.This study aimed to describe clinical and laboratory.characteristics of a population of patients with asthma and to investigate the potential

Published
2024

7. RIAIT (Italian Registry of Allergen Immunotherapy): Protocol for a New Tool in a New Vision of Disease-Modifying Therapy for Allergists.

Author

Costanzo, Giovanni, Caruso, Cristiano, Paoletti, Giovanni, Baglivo, Ilaria, Colantuono, Stefania, Bagnasco, Diego, Caminati, Marco, Giovannini, Mattia, Castagnoli, Riccardo, Senna, Gianenrico, Sirena, Concetta, Tosca, Maria Angela, Passalacqua, Giovanni, Marseglia, Gian Luigi, Miraglia del Giudice, Michele, Ciprandi, Giorgio, Indolfi, Cristiana, Barberi, Salvatore, Landi, Massimo, and Di Gioacchino, Mario

Subjects
ALLERGY desensitization, VISUAL training, RANDOMIZED controlled trials, QUALITY of life, ALLERGIES
Abstract

Randomized controlled trials have demonstrated responses to clinical parameters, but a significant proportion of allergy patients in real-life settings would have been excluded from such studies. Therefore, real-world research is needed, and there is a growing body of information on allergen immunotherapy's long-term effectiveness and safety. Real-world evidence can be a valuable instrument to better understand the patient's journey and the effectiveness and safety of therapies. For this purpose, a registry will be used for the first time in Italy to evaluate the impact of allergen immunotherapy on several outcomes, including quality of life and disease-related effects in the pediatric and adult allergic population with a socio-economic assessment and respect to real-world health. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Reduction of daily maintenance inhaled corticosteroids in patients with severe eosinophilic asthma treated with benralizumab (SHAMAL): a randomised, multicentre, open-label, phase 4 study

Author

Jackson, David J, primary, Heaney, Liam G, additional, Humbert, Marc, additional, Kent, Brian D, additional, Shavit, Anat, additional, Hiljemark, Lina, additional, Olinger, Lynda, additional, Cohen, David, additional, Menzies-Gow, Andrew, additional, Korn, Stephanie, additional, Kroegel, Claus, additional, Caruso, Cristiano, additional, Baglivo, Ilaria, additional, Colantuono, Stefania, additional, Jackson, David, additional, Skowasch, Dirk, additional, Di Marco, Fabiano, additional, Couturaud, Francis, additional, Käßner, Frank, additional, Cwiek, Iwona, additional, Teber, Markus, additional, Knetsch, Kornelia, additional, Preuß, Jasmin, additional, Devouassoux, Gilles, additional, Milger-Kneidinger, Katrin, additional, Heaney, Liam, additional, Jerrentrup, Lukas, additional, Jandl, Margret, additional, Timmermann, Hartmut, additional, Probst, Beatrice, additional, D'Amato, Maria, additional, Hoffmann, Martin, additional, Bonniaud, Philippe, additional, Beltramo, Guillaume, additional, Girodet, Pierre-Olivier, additional, Berger, Patrick, additional, Nasser, Shuaib, additional, Fry, Stéphanie, additional, Aries, Sven Philip, additional, Koehler, Thomas, additional, and Harrison, Timothy, additional

Published
2024
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11. Safety and effectiveness of biosimilar of Rituximab CT-P10 in the treatment of cryoglobulinemic vasculitis: the MARBLe study (Mixed cryoglobulinemiA Rituximab BiosimiLar)

Author

Vacchi, Caterina, Visentini, Marcella, Gragnani, Laura, Fraticelli, Paolo, Tavoni, Antonio, Filippini, Davide, Saccardo, Francesco, Lauletta, Gianfranco, Colantuono, Stefania, Atzeni, Fabiola, Pioltelli, Pietro, Manfredi, Andreina, Casato, Milvia, Zignego, Anna Linda, Monti, Giuseppe, Pietrogrande, Maurizio, Galli, Massimo, and Sebastiani, Marco

Published
2021
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13. Immunoglobulin Free Light Chains in Severe Asthma Patient: could they be a new biomarker?

Author

Caruso, Cristiano, primary, Ciasca, Gabriele, additional, Baglivo, *, additional, Santo, Riccardo Di, additional, Gasbarrini, Antonio, additional, Firinu, Davide, additional, Bagnasco, Diego, additional, Passalacqua, Giovanni, additional, Schiappoli, Michele, additional, Caminati, Marco, additional, Canonica, Giorgio Walter, additional, Heffler, Enrico, additional, Crimi, Claudia, additional, Intravaia, Rossella, additional, V., Basile, additional, Marino, Mariapaola, additional, colantuono, stefania, additional, and Giacco, Stefano R. Del, additional

Published
2023
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14. Dual stimulation by autoantigen and CpG fosters the proliferation of exhausted rheumatoid factor-specific CD21low B cells in hepatitis C virus-cured mixed cryoglobulinemia.

Author

Del Padre, Martina, Marrapodi, Ramona, Minafò, Ylenia A., Mortari, Eva Piano, Radicchio, Giovanna, Bocci, Chiara, Gragnani, Laura, Camponeschi, Alessandro, Colantuono, Stefania, Stefanini, Lucia, Basili, Stefania, Carsetti, Rita, Fiorilli, Massimo, Casato, Milvia, and Visentini, Marcella

Subjects
B cells, B cell receptors, CRYOGLOBULINEMIA, HEPATITIS B, IMMUNE complexes, RHEUMATOID factor
Abstract

Introduction: Hepatitis C virus (HCV) causes mixed cryoglobulinemia (MC) by driving clonal expansion of B cells expressing B cell receptors (BCRs), often encoded by the VH1-69 variable gene, endowed with both rheumatoid factor (RF) and anti-HCV specificity. These cells display an atypical CD21low phenotype and functional exhaustion evidenced by unresponsiveness to BCR and Toll-like receptor 9 (TLR9) stimuli. Although antiviral therapy is effective on MC vasculitis, pathogenic B cell clones persist long thereafter and can cause virus-independent disease relapses. Methods: Clonal B cells from patients with HCV-associated type 2 MC or healthy donors were stimulated with CpG or heath-aggregated IgG (as surrogate immune complexes) alone or in combination; proliferation and differentiation were then evaluated by flow cytometry. Phosphorylation of AKT and of the p65 NF-kB subunit were measured by flow cytometry. TLR9 was quantified by qPCR and by intracellular flow cytometry, and MyD88 isoforms were analyzed using RT-PCR. Discussion: We found that dual triggering with autoantigen and CpG restored the capacity of exhausted VH1-69pos B cells to proliferate. The signaling mechanism for this BCR/TLR9 crosstalk remains elusive, since TLR9 mRNA and protein as well as MyD88 mRNA were normally expressed and CpG-induced phosphorylation of p65 NF-kB was intact in MC clonal B cells, whereas BCR-induced p65 NF-kB phosphorylation was impaired and PI3K/Akt signaling was intact. Our findings indicate that autoantigen and CpG of microbial or cellular origin may unite to foster persistence of pathogenic RF B cells in HCV-cured MC patients. BCR/TLR9 crosstalk might represent a more general mechanism enhancing systemic autoimmunity by the rescue of exhausted autoreactive CD21low B cells. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Clinical research coordinators: Key components of an efficient clinical trial unit

Author

Mora, Vincenzina, primary, Colantuono, Stefania, additional, Fanali, Caterina, additional, Leonetti, Alessia, additional, Wlderk, Giulia, additional, Pirro, Maria Antonia, additional, Calà Palmarino, Francesca Maria, additional, Savini, Roberta, additional, Ianiro, Gianluca, additional, Gasbarrini, Antonio, additional, Celeste, Pirozzoli Maria, additional, Luciana, Giannone, additional, Cristina, Spataro, additional, Cristina, Graziani, additional, Anna, Capodrossi, additional, Anna, Teberino Maria, additional, Barbara, Tolusso, additional, Marica, Di Ciurcio, additional, Diana, Verdirosi, additional, Serena, Rotunno, additional, Ludovica, Finotti, additional, Laura, Turchini, additional, Valeria, Amatucci, additional, Elisa, Schiavoni, additional, Daniele, Napolitano, additional, Eleonora, Durini, additional, Martina, Strazzeri, additional, Teresa, Lombardi Maria, additional, and Elisabetta, Schifano, additional

Published
2023
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16. Clinical research coordinators: Key components of an efficient clinical trial unit

Author

Mora, Vincenzina, Colantuono, Stefania, Fanali, Caterina, Leonetti, Alessia, Wlderk, Giulia, Pirro, Maria Antonia, Calà Palmarino, Francesca Maria, Savini, Roberta, Ianiro, Gianluca, Gasbarrini, Antonio, Ianiro, Gianluca (ORCID:0000-0002-8318-0515), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Mora, Vincenzina, Colantuono, Stefania, Fanali, Caterina, Leonetti, Alessia, Wlderk, Giulia, Pirro, Maria Antonia, Calà Palmarino, Francesca Maria, Savini, Roberta, Ianiro, Gianluca, Gasbarrini, Antonio, Ianiro, Gianluca (ORCID:0000-0002-8318-0515), and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)

Abstract

N/A

Published
2023

17. Delayed hypersensitivity to dimethyl fumarate: Report of 1 case and literature review

Author

Baglivo, Ilaria, Colantuono, Stefania, Caruso, Cristiano, De Fino, Chiara, Gasbarrini, Antonio, Capone, Manuela, D'Amore, Alessandra, Peris, Ketty, Romano, Antonino, Parronchi, Paola, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Peris, Ketty (ORCID:0000-0002-5237-0463), Romano, Antonino (ORCID:0000-0003-3762-2084), Baglivo, Ilaria, Colantuono, Stefania, Caruso, Cristiano, De Fino, Chiara, Gasbarrini, Antonio, Capone, Manuela, D'Amore, Alessandra, Peris, Ketty, Romano, Antonino, Parronchi, Paola, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Peris, Ketty (ORCID:0000-0002-5237-0463), and Romano, Antonino (ORCID:0000-0003-3762-2084)

Abstract

N/A

Published
2023

18. Different aspects of severe asthma in real life: Role of Staphylococcus aureus enterotoxins and correlation to comorbidities and disease severity

Author

Caruso, Cristiano, Colantuono, Stefania, Ciasca, Gabriele, Basile, Umberto, Di Santo, Riccardo, Bagnasco, Diego, Passalacqua, Giovanni, Caminati, Marco, Michele, Schiappoli, Senna, Gianenrico, Heffler, Enrico, Canonica, G Walter, Crimi, Nunzio, Intravaia, Rossella, De Corso, Eugenio, Firinu, Davide, Gasbarrini, Antonio, Del Giacco, Stefano R, Ciasca, Gabriele (ORCID:0000-0002-3694-8229), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Caruso, Cristiano, Colantuono, Stefania, Ciasca, Gabriele, Basile, Umberto, Di Santo, Riccardo, Bagnasco, Diego, Passalacqua, Giovanni, Caminati, Marco, Michele, Schiappoli, Senna, Gianenrico, Heffler, Enrico, Canonica, G Walter, Crimi, Nunzio, Intravaia, Rossella, De Corso, Eugenio, Firinu, Davide, Gasbarrini, Antonio, Del Giacco, Stefano R, Ciasca, Gabriele (ORCID:0000-0002-3694-8229), and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)

Abstract

Background: Asthma, with several phenotypes and endotypes, is considered particularly suited for precision medicine. The identification of different non-invasive biomarkers may facilitate diagnosis and treatment. Recently, Staphylococcus aureus and its enterotoxins (SE) have been found to have a role in inducing persistent type 2 airway inflammation in severe asthma, but also in such comorbidities as chronic rhinosinusitis with nasal polyposis (CRSwNP). Methods: The aim of this retrospective study was to evaluate the prevalence of SE-IgE sensitization in a multicentric Italian cohort of severe asthmatic patients and correlate it with demographic and clinical characteristics. Results: A total of 249 patients were included in the analysis, out of which 25.3% were staphylococcal enterotoxin B (SEB)-IgE positive. We found a meaningful association between SEB-IgE and female gender, a positive association was also measured between CRS and CRSwNP. No significant association was found between SEB-IgE sensitization and atopy, the occurrence of exacerbations and corticosteroid dosages. In the SEB-IgE-positive patient, blood eosinophil count does not appear to be correlated with the severity of the disease. Patients with SEB-IgE sensitization are, on average, younger and with an earlier disease onset, thus confirming the possibility to consider SEB-IgE sensitization as an independent risk factor for developing asthma. Conclusions: Our data confirm that the search for SE in the initial screening phase of these patients is helpful to better phenotype them, may predict the evolution of comorbidities and lead to a targeted therapeutic choice; in this point of view this represents a goal of precision medicine.

Published
2023

19. Dual stimulation by autoantigen and CpG fosters the proliferation of exhausted rheumatoid factor-specific CD21low B cells in hepatitis C virus-cured mixed cryoglobulinemia

Author

Del Padre, Martina, primary, Marrapodi, Ramona, additional, Minafò, Ylenia A., additional, Piano Mortari, Eva, additional, Radicchio, Giovanna, additional, Bocci, Chiara, additional, Gragnani, Laura, additional, Camponeschi, Alessandro, additional, Colantuono, Stefania, additional, Stefanini, Lucia, additional, Basili, Stefania, additional, Carsetti, Rita, additional, Fiorilli, Massimo, additional, Casato, Milvia, additional, and Visentini, Marcella, additional

Published
2023
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21. Efficacy of low-dose rituximab for the treatment of mixed cryoglobulinemia vasculitis: Phase II clinical trial and systematic review

Author

Visentini, Marcella, Tinelli, Carmine, Colantuono, Stefania, Monti, Monica, Ludovisi, Serena, Gragnani, Laura, Mitrevski, Milica, Ranieri, Jessica, Fognani, Elisa, Piluso, Alessia, Granata, Massimo, De Silvestri, Annalisa, Scotti, Valeria, Mondelli, Mario U., Zignego, Anna Linda, Fiorilli, Massimo, and Casato, Milvia

Published
2015
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24. Clinical research coordinators: Key components of an efficient clinical trial unit

Author

Celeste, Pirozzoli Maria, Luciana, Giannone, Cristina, Spataro, Cristina, Graziani, Anna, Capodrossi, Anna, Teberino Maria, Barbara, Tolusso, Marica, Di Ciurcio, Diana, Verdirosi, Serena, Rotunno, Ludovica, Finotti, Laura, Turchini, Valeria, Amatucci, Elisa, Schiavoni, Daniele, Napolitano, Eleonora, Durini, Martina, Strazzeri, Teresa, Lombardi Maria, Elisabetta, Schifano, Mora, Vincenzina, Colantuono, Stefania, Fanali, Caterina, Leonetti, Alessia, Wlderk, Giulia, Pirro, Maria Antonia, Calà Palmarino, Francesca Maria, Savini, Roberta, Ianiro, Gianluca, and Gasbarrini, Antonio

Published
2023
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25. Different aspects of severe asthma in real life: Role of Staphylococcus aureus enterotoxins and correlation to comorbidities and disease severity

Author

Caruso, Cristiano, primary, Colantuono, Stefania, additional, Ciasca, Gabriele, additional, Basile, Umberto, additional, Di Santo, Riccardo, additional, Bagnasco, Diego, additional, Passalacqua, Giovanni, additional, Caminati, Marco, additional, Michele, Schiappoli, additional, Senna, Gianenrico, additional, Heffler, Enrico, additional, Canonica, G. Walter, additional, Crimi, Nunzio, additional, Intravaia, Rossella, additional, De Corso, Eugenio, additional, Firinu, Davide, additional, Gasbarrini, Antonio, additional, and Del Giacco, Stefano R., additional

Published
2022
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26. Heterogeneous Condition of Asthmatic Children Patients: A Narrative Review

Author

Caruso, Cristiano, Colantuono, Stefania, Arasi, Stefania, Nicoletti, Alberto, Gasbarrini, Antonio, Coppola, Angelo, Di Michele, Loreta, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Caruso, Cristiano, Colantuono, Stefania, Arasi, Stefania, Nicoletti, Alberto, Gasbarrini, Antonio, Coppola, Angelo, Di Michele, Loreta, and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)

Abstract

Currently, asthma represents the most common chronic disorder in children, showing an increasingly consistent burden worldwide. Childhood asthma, similar to what happens in adults, is a diversified disease with a great variability of phenotypes, according to genetic predisposition of patients, age, severity of symptoms, grading of risk, and comorbidities, and cannot be considered a singular well-defined disorder, but rather a uniquely assorted disorder with variable presentations throughout childhood. Despite several developments occurring in recent years in pediatric asthma, above all, in the management of the disease, some essential areas, such as the improvement of pediatric asthma outcomes, remain a hot topic. Most treatments of the type 2 (T2) target phenotype of asthma, in which IL-4, IL-5, and IL-13 modulate the central signals of inflammatory reactions. Although, there may be an unresolved need to identify new biomarkers used as predictors to improve patient stratification using disease systems and to aid in the selection of treatments. Moreover, we are globally facing many dramatic challenges, including climate change and the SARS-CoV2 pandemic, which have a considerable impact on children and adolescent asthma. Preventive strategies, including allergen immunotherapy and microbiome evaluation, and targeted therapeutic strategies are strongly needed in this population. Finally, the impact of asthma on sleep disorders has been reviewed.

Published
2022

29. Severe asthma: One disease and multiple definitions

Author

Bagnasco, Diego, primary, Paggiaro, Pierluigi, additional, Latorre, Manuela, additional, Folli, Chiara, additional, Testino, Elisa, additional, Bassi, Arianna, additional, Milanese, Manlio, additional, Heffler, Enrico, additional, Manfredi, Andrea, additional, Riccio, Anna Maria, additional, De Ferrari, Laura, additional, Blasi, Francesco, additional, Canevari, Rikki Frank, additional, Canonica, Giorgio Walter, additional, Passalacqua, Giovanni, additional, Guarnieri, Gabriella, additional, Patella, Vincenzo, additional, Maria Pia, Foschino Barbaro, additional, Carpagnano, Giovanna Elisiana, additional, Colle, Anna del, additional, Scioscia, Giulia, additional, Gerolamo, Pelaia, additional, Puggioni, Francesca, additional, Racca, Francesca, additional, Favero, Elisabetta, additional, Iannacone, Sandra, additional, Savi, Eleonora, additional, Montagni, Marcello, additional, Camiciottoli, Gianna, additional, Allegrini, Chiara, additional, Lombardi, Carlo, additional, Spadaro, Giuseppe, additional, Detoraki, Caterina, additional, Menzella, Francesco, additional, Galeone, Carla, additional, Ruggiero, Patrizia, additional, Yacoub, Monna Rita, additional, Berti, Alvise, additional, Scichilone, Nicola, additional, Durante, Carmen, additional, Costantino, Maria Teresa, additional, Roncallo, Chiara, additional, Braschi, Mariachiara, additional, D’Adda, Alice, additional, Ridolo, Erminia, additional, Triggiani, Massimo, additional, Parente, Roberta, additional, Maria, D’Amato, additional, Verrillo, Maria Vittoria, additional, Rolla, Giovanni, additional, Brussino, Luisa, additional, Frazzetto, Agata Valentina, additional, Cristina, Zappa Maria, additional, Lilli, Marianna, additional, Crimi, Nunzio, additional, Bonavia, Marco, additional, Corsico, Angelo Guido, additional, Grosso, Amelia, additional, Del Giacco, Stefano, additional, Deidda, Margherita, additional, Ricciardi, Luisa, additional, Isola, Stefania, additional, Cicero, Francesca, additional, Amato, Giuliana, additional, Vita, Federica, additional, Spanevello, Antonio, additional, Pignatti, Patrizia, additional, Cherubino, Francesca, additional, Visca, Dina, additional, Massimo Ricciardolo, Fabio Luigi, additional, Anna Carriero, Vitina Maria, additional, Bertolini, Francesca, additional, Santus, Pierachille, additional, Barlassina, Roberta, additional, Airoldi, Andrea, additional, Guida, Giuseppe, additional, Eleonora, Nucera, additional, Aruanno, Arianna, additional, Rizzi, Angela, additional, Caruso, Cristiano, additional, Colantuono, Stefania, additional, Senna, Gianenrico, additional, Caminati, Marco, additional, Arcolaci, Alessandra, additional, Vianello, Andrea, additional, Bianchi, Fulvia Chieco, additional, Marchi, Maria Rita, additional, Centanni, Stefano, additional, Luraschi, Simone, additional, Ruggeri, Silvia, additional, Rinaldo, Rocco, additional, Parazzini, Elena, additional, Calabrese, Cecilia, additional, Flora, Martina, additional, Cosmi, Lorenzo, additional, Di Pietro, Linda, additional, Maggi, Enrico, additional, Pini, Laura, additional, Macchia, Luigi, additional, Di Bona, Danilo, additional, Richeldi, Luca, additional, Condoluci, Carola, additional, Fuso, Leonello, additional, Bonini, Matteo, additional, Farsi, Alessandro, additional, Carli, Giulia, additional, Montuschi, Paolo, additional, Santini, Giuseppe, additional, Conte, Maria Elisabetta, additional, Turchet, Elisa, additional, Barbetta, Carlo, additional, Mazza, Francesco, additional, D’Alo, Simona, additional, Pucci, Stefano, additional, Caiaffa, Maria Filomena, additional, Minenna, Elena, additional, D'Elia, Luciana, additional, Pasculli, Carlo, additional, Viviano, Vittorio, additional, Tarsia, Paolo, additional, Rolo, Joyce, additional, Di Proietto, Mariacarmela, additional, and Lo Cicero, Salvatore, additional

Published
2021
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31. Autoimmune hepatitis with eosinophilic infiltration responsive to anti-interleukin-5 receptor treatment: a case report and literature review.

Author

Ponziani, Francesca Romana, Caruso, Cristiano, Baglivo, Ilaria, Macagno, Francesco, Gasbarrini, Antonio, Santopaolo, Francesco, Giustiniani, Maria Cristina, Colantuono, Stefania, and Pompili, Maurizio

Abstract

Inflammatory tissue damage plays a role in the onset, progression, and exacerbation of various chronic autoimmune and metabolic diseases such as autoimmune hepatitis. Here we present a case of autoimmune hepatitis with liver eosinophilic infiltrate in a severe eosinophilic asthma patient who failed conventional immunosuppressive treatment and showed improvement in gastrointestinal symptoms after anti-interleukin-5 receptor treatment. Our case highlights the potential role of eosinophils in initiating or worsening liver inflammation in autoimmune liver disease. The link between eosinophilic inflammation, barrier damage, and chronic autoimmune diseases should be considered in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2023
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33. β-Lactam Allergy and Cross-Reactivity: A Clinician’s Guide to Selecting an Alternative Antibiotic

Author

Caruso,Cristiano, Valluzzi,Rocco Luigi, Colantuono,Stefania, Gaeta,Francesco, and Romano,Antonino

Subjects
polycyclic compounds, Journal of Asthma and Allergy, biochemical phenomena, metabolism, and nutrition
Abstract

Cristiano Caruso,1 Rocco Luigi Valluzzi,2 Stefania Colantuono,1 Francesco Gaeta,1 Antonino Romano3,4 1Allergy Unit, Columbus Hospital, Fondazione Policlinico A. Gemelli, IRCCS, Rome, Italy; 2Department of Pediatrics, Division of Allergy, Pediatric Hospital Bambino Gesù, Rome, Vatican City, Italy; 3Oasi Research Institute-IRCCS, Troina, Italy; 4Fondazione Mediterranea G.B. Morgagni, Catania, ItalyCorrespondence: Cristiano Caruso Tel +393348079133Email cristiano.caruso@policlinicogemelli.itAbstract: β-Lactams which include penicillins, cephalosporins, carbapenems, and monobactams are the most common antibiotic classes reported to cause allergic reactions to drugs. This review is mainly about published studies assessing the cross-reactivity among β-lactams in penicillin- or cephalosporin-allergic subjects by carrying out diagnostic tests with alternative β-lactams and, if appropriate, graded challenges. Several studies demonstrated that cross-reactivity connected with the β-lactam ring, causing positive responses to allergy tests with all β-lactams, is infrequent in subjects with an IgE-mediated allergy and anecdotal in those with a T-cell-mediated allergy. Identities or similarities of β-lactam side-chain structures are mainly responsible for cross-reactivity among these antibiotics. For example, in aminopenicillin-allergic subjects, cross-reactivity with aminocephalosporins could possibly be over 30%. On the other hand, in a few prospective studies of penicillin-allergic individuals, less than 1% of cases show a cross-reactivity between penicillins and both aztreonam and carbapenems. Particular patterns of allergy-test positivity observed in some studies that assessed cross-reactivity among β-lactams seem to indicate that prior exposures may be responsible for coexisting sensitivities. Therefore, pre-treatment skin tests with the related β-lactams are suggested before administering them via graded challenges to β-lactam-allergic patients who need alternative β-lactams.Keywords: aztreonam, β-lactams, carbapenems, cephalosporins, cross-reactivity, hypersensitivity, penicillins, skin tests

Published
2021

34. Solving the mystery of HBV-related mixed cryoglobulinemia: potential biomarkers of disease progression

Author

Pocino, Krizia, Napodano, Cecilia, Gragnani, Laura, Ciasca, Gabriele, Colantuono, Stefania, Marri, Silvia, Vantaggio, Lorenzo, Gulli, Francesca, Lorini, Serena, Barini, Antonella, Stefanile, Annunziata, Miele, Luca, Casato, Milvia, Zignego, Anna Linda, Rapaccini, Gian Ludovico, Marino, Mariapaola, Visentini, Marcella, Basile, Umberto, Pocino, Krizia (ORCID:0000-0003-2456-5308), Napodano, Cecilia (ORCID:0000-0002-8720-6284), Ciasca, Gabriele (ORCID:0000-0002-3694-8229), Miele, Luca (ORCID:0000-0003-3464-0068), Rapaccini, Gian Ludovico (ORCID:0000-0002-6467-857X), Marino, Mariapaola (ORCID:0000-0001-9155-6378), Pocino, Krizia, Napodano, Cecilia, Gragnani, Laura, Ciasca, Gabriele, Colantuono, Stefania, Marri, Silvia, Vantaggio, Lorenzo, Gulli, Francesca, Lorini, Serena, Barini, Antonella, Stefanile, Annunziata, Miele, Luca, Casato, Milvia, Zignego, Anna Linda, Rapaccini, Gian Ludovico, Marino, Mariapaola, Visentini, Marcella, Basile, Umberto, Pocino, Krizia (ORCID:0000-0003-2456-5308), Napodano, Cecilia (ORCID:0000-0002-8720-6284), Ciasca, Gabriele (ORCID:0000-0002-3694-8229), Miele, Luca (ORCID:0000-0003-3464-0068), Rapaccini, Gian Ludovico (ORCID:0000-0002-6467-857X), and Marino, Mariapaola (ORCID:0000-0001-9155-6378)

Abstract

OBJECTIVES: The biomarkers of an immunological dysregulation due to a chronic Hepatitis B virus (HBV) infection are indeed understudied. If untreated, this condition may evolve into liver impairment also co-occurred by extrahepatic involvements. Here, we aim to identify a new panel of biomarkers including IgG subclasses, Rheumatoid Factor (RF), and Free Light Chains (FLC) that may result useful and reliable for clinical evaluation of HBV-related cryoglobulinemia.METHODS: We retrospectively analyzed clinical data from 44 HBV positive patients. Patients were stratified on the presence/absence of mixed cryoglobulinemia in two group: 22 with cryoglobulins (CGs) and 22 without CGs. Samples from 20 healthy blood donors (HD) were used as negative controls. Serum samples were tested for IgG subclasses, RF (IgM, IgG, and IgA type), and FLC.RESULTS: We detected a strikingly different serum IgG subclasses distribution between HD and HBV positive patients together with different RF isotypes; FLC were significantly increased in HBV-patients if compared with HD while no significant difference was shown between HBV with/without MC.CONCLUSION: The immune-inflammatory response triggered by HBV may be monitored by a peculiar profile of biomarkers. Our results open new perspective in precision medicine era; in these challenging times, they could be also employed to monitor the clinical course of COVID-19 patients, at high risk of HBV reactivation due to liver impairment and/or immunosuppressive therapies.

Published
2021

35. Real-life survey on severe asthma patients during COVID-19 lockdown in Italy

Author

Caruso, Cristiano, Colantuono, Stefania, Urbani, Sara, Heffler, Enrico, Canonica, Giorgio Walter, Andriollo, Gloria, Di Michele, Loreta, Scarlata, Simone, Zennaro, Danila, Rigon, Amelia, Vadacca, Marta, Moroni, Rossana, Nucera, Eleonora, Gasbarrini, Antonio, Nucera, Eleonora (ORCID:0000-0002-0565-7680), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Caruso, Cristiano, Colantuono, Stefania, Urbani, Sara, Heffler, Enrico, Canonica, Giorgio Walter, Andriollo, Gloria, Di Michele, Loreta, Scarlata, Simone, Zennaro, Danila, Rigon, Amelia, Vadacca, Marta, Moroni, Rossana, Nucera, Eleonora, Gasbarrini, Antonio, Nucera, Eleonora (ORCID:0000-0002-0565-7680), and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)

Abstract

Introduction: The SARS-CoV-2 pandemic has deeply revolutionized our lives and consequently the management of patients, specifically ones with severe asthma.Objective: A survey was conducted to evaluate the effects on adherence, exacerbations and quality of life in patients with severe asthma during the COVID-19 pandemic period.Methods: 100 severe asthma patients, who accepted to participate to the survey, were asked to respond to different questionnaires in order to assess asthma symptoms (Asthma Control Test - ACT, and Asthma Control Quality - ACQ) and rino-sinusal ones (Sino-nasal outcome test - SNOT-22).Results: 31 out of 100 patients reported worsening of respiratory symptoms requiring a step-up in therapy dosage or frequency during the observational period; however, exacerbation rate was very low. Only 17 (17%) of the 100 participants experienced a severe asthma exacerbation. Moreover, there was no confirmed diagnosis of COVID-19 in this population.Conclusion: Patients with severe asthma did not show higher rates of exacerbations during the pandemic outbreak as well as no increased risk of contracting COVID-19 infection or developing the disease. Self-administration of biological drugs could be useful to maintain high rates of adherence to therapy, and, at the same time, to decrease the risk of exacerbations or Intensive Care Unit (ICU) room access.

Published
2021

37. Cryoglobulins: putative effectors of adaptive immune response

Author

Basile, Umberto, primary, Napodano, Cecilia, additional, Marino, Mariapaola, additional, Gulli, Francesca, additional, Colantuono, Stefania, additional, Casato, Milvia, additional, Pocino, Krizia, additional, Basile, Valerio, additional, Todi, Laura, additional, Rapaccini, Gian Ludovico, additional, and Visentini, Marcella, additional

Published
2021
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38. Real-life survey on severe asthma patients during COVID-19 lockdown in Italy

Author

Caruso, Cristiano, primary, Colantuono, Stefania, additional, Urbani, Sara, additional, Heffler, Enrico, additional, Canonica, Giorgio Walter, additional, Andriollo, Gloria, additional, Di Michele, Loreta, additional, Scarlata, Simone, additional, Zennaro, Danila, additional, Rigon, Amelia, additional, Vadacca, Marta, additional, Moroni, Rossana, additional, Nucera, Eleonora, additional, and Gasbarrini, Antonio, additional

Published
2021
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39. Mutational and immunogenetic landscape of HCV ‐associated B‐cell lymphoproliferative disorders

Author

Defrancesco, Irene, primary, Visentini, Marcella, additional, Zibellini, Silvia, additional, Minafò, Ylenia Aura, additional, Rattotti, Sara, additional, Ferretti, Virginia Valeria, additional, Rizzo, Ettore, additional, Varettoni, Marzia, additional, Frigeni, Marco, additional, Pulsoni, Alessandro, additional, Casato, Milvia, additional, Colantuono, Stefania, additional, Rossi, Marianna, additional, Candido, Chiara, additional, Zerbi, Caterina, additional, Bergamini, Fabio, additional, Cristinelli, Caterina, additional, Fabbri, Nicole, additional, Merli, Michele, additional, Zuccaro, Valentina, additional, Bruno, Raffaele, additional, Paulli, Marco, additional, and Arcaini, Luca, additional

Published
2021
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40. Cryoglobulins: putative effectors of adaptive immune response

Author

Basile, Umberto, Napodano, Cecilia, Marino, Mariapaola, Gulli, Francesca, Colantuono, Stefania, Casato, Milvia, Pocino, Krizia, Basile, Valerio, Todi, Laura, Rapaccini, Gian Ludovico, Visentini, Marcella, Napodano, Cecilia (ORCID:0000-0002-8720-6284), Marino, Mariapaola (ORCID:0000-0001-9155-6378), Pocino, Krizia (ORCID:0000-0003-2456-5308), Rapaccini, Gian Ludovico (ORCID:0000-0002-6467-857X), Basile, Umberto, Napodano, Cecilia, Marino, Mariapaola, Gulli, Francesca, Colantuono, Stefania, Casato, Milvia, Pocino, Krizia, Basile, Valerio, Todi, Laura, Rapaccini, Gian Ludovico, Visentini, Marcella, Napodano, Cecilia (ORCID:0000-0002-8720-6284), Marino, Mariapaola (ORCID:0000-0001-9155-6378), Pocino, Krizia (ORCID:0000-0003-2456-5308), and Rapaccini, Gian Ludovico (ORCID:0000-0002-6467-857X)

Abstract

Cryoglobulinaemia consists of circulating monoclonal and/or polyclonal immunoglobulins with rheumatoid factor (RF) activity that precipitate at temperatures <37 °C. Cryoglobulinaemic syndrome, characterised by clinical signs of systemic vasculitis, is associated with chronic infection of hepatitis C virus (HCV) and might evolve in B-cell malignancies. In about one third of all HCV infection cases, serum autoantibodies are commonly found. This is probably due directly to the transformation of infected B cells but, also, indirectly, to the viral chronic stimulation of a pool of autoreactive B cells. The pattern of IgG subclasses seems to contribute to the worsening progression of HCV infection into lymphoproliferative and/or autoimmune diseases. Many evidences showed that B cells circulating in patients with HCV-associated mixed cryoglobulinaemia (MC) are profoundly abnormal; moreover, in most of cases, normal B cells are replaced by expanded clonal B cells characterized by the low expression of CD21. After viral eradication, these cells persist in circulation and their occurrence does not correlate with serum cryoglobulins nor with vasculitis response or relapse. It is probably due to the persistence of monoclonal B cells producing RF, that in course of MC can be reactivated by circulating immune complexes, highly produced during infections or tumours. Here, we aimed to review current literature focusing the pathogenesis of MC referring to specificity and immunochemical characteristics of the immunoglobulins involved in cryoprecipitation.

Published
2020

41. Solving the mystery of HBV-related mixed cryoglobulinemia: potential biomarkers of disease progression

Author

Pocino, Krizia, primary, Napodano, Cecilia, additional, Gragnani, Laura, additional, Ciasca, Gabriele, additional, Colantuono, Stefania , additional, Marri, Silvia, additional, Vantaggio, Lorenzo, additional, Gulli, Francesca, additional, Lorini, Serena, additional, Barini, Antonella, additional, Stefanile, Annunziata, additional, Miele, Luca, additional, Casato, Milvia, additional, Zignego, Anna Linda, additional, Rapaccini, Gian Ludovico, additional, Marino, Mariapaola, additional, Visentini, Marcella, additional, and Basile, Umberto, additional

Published
2021
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42. Economic impact of mepolizumab in uncontrolled severe eosinophilic asthma, in real life

Author

Bagnasco, Diego, primary, Povero, Massimiliano, additional, Pradelli, Lorenzo, additional, Brussino, Luisa, additional, Rolla, Giovanni, additional, Caminati, Marco, additional, Menzella, Francesco, additional, Heffler, Enrico, additional, Canonica, Giorgio Walter, additional, Paggiaro, Pierluigi, additional, Senna, Gianenrico, additional, Milanese, Manlio, additional, Lombardi, Carlo, additional, Bucca, Caterina, additional, Manfredi, Andrea, additional, Canevari, Rikki Frank, additional, Passalacqua, Giovanni, additional, Guarnieri, Gabriella, additional, Patella, Vincenzo, additional, Maria Pia, Foschino Barbaro, additional, Carpagnano, Elisiana, additional, Colle, Anna del, additional, Scioscia, Giulia, additional, Gerolamo, Pelaia, additional, Latorre, Manuela, additional, Puggioni, Francesca, additional, Racca, Francesca, additional, Favero, Elisabetta, additional, Iannacone, Sandra, additional, Savi, Eleonora, additional, Montagni, Marcello, additional, Camiciottoli, Gianna, additional, Allegrini, Chiara, additional, Spadaro, Giuseppe, additional, Detoraki, Caterina, additional, Galeone, Carla, additional, Ruggiero, Patrizia, additional, Yacoub, Monna Rita, additional, Berti, Alvise, additional, Colombo, Gisella, additional, Scichilone, Nicola, additional, Durante, Carmen, additional, Costantino, Maria Teresa, additional, Roncallo, Chiara, additional, Braschi, Mariachiara, additional, Blasi, Francesco, additional, D'Adda, Alice, additional, Ridolo, Erminia, additional, Triggiani, Massimo, additional, Parente, Roberta, additional, Maria, D'Amato, additional, Verrillo, Maria Vittoria, additional, Cristina, Zappa Maria, additional, Lilli, Marianna, additional, Crimi, Nunzio, additional, Bonavia, Marco, additional, Corsico, Angelo Guido, additional, Grosso, Amelia, additional, Del Giacco, Stefano, additional, Deidda, Margherita, additional, Ricciardi, Luisa, additional, Isola, Stefania, additional, Cicero, Francesca, additional, Amato, Giuliana, additional, Vita, Federica, additional, Spanevello, Antonio, additional, Pignatti, Patrizia, additional, Cherubino, Francesca, additional, Visca, Dina, additional, Aletti, Eleonora, additional, Massimo Ricciardolo, Fabio Luigi, additional, Anna Carriero, Vitina Maria, additional, Bertolini, Francesca, additional, Santus, Pierachille, additional, Barlassina, Roberta, additional, Airoldi, Andrea, additional, Guida, Giuseppe, additional, Eleonora, Nucera, additional, Aruanno, Arianna, additional, Rizzi, Angela, additional, Caruso, Cristiano, additional, Colantuono, Stefania, additional, Arcolaci, Alessandra, additional, Vianello, Andrea, additional, Bianchi, Fulvia Chieco, additional, Marchi, Maria Rita, additional, Centanni, Stefano, additional, Luraschi, Simone, additional, Ruggeri, Silvia, additional, Rinaldo, Rocco, additional, Parazzini, Elena, additional, Calabrese, Cecilia, additional, Flora, Martina, additional, Cosmi, Lorenzo, additional, Di Pietro, Linda, additional, Maggi, Enrico, additional, Pini, Laura, additional, Macchia, Luigi, additional, Di Bona, Danilo, additional, Richeldi, Luca, additional, Condoluci, Carola, additional, Fuso, Leonello, additional, Bonini, Matteo, additional, Farsi, Alessandro, additional, Carli, Giulia, additional, Montuschi, Paolo, additional, Santini, Giuseppe, additional, Conte, Maria Elisabetta, additional, Turchet, Elisa, additional, Barbetta, Carlo, additional, Mazza, Francesco, additional, D'Alo, Simona, additional, Pucci, Stefano, additional, Caiaffa, Maria Filomena, additional, Minenna, Elena, additional, D'Elia, Luciana, additional, Pasculli, Carlo, additional, Viviano, Vittorio, additional, Tarsia, Paolo, additional, Rolo, Joyce, additional, Di Proietto, Mariacarmela, additional, and Lo Cicero, Salvatore, additional

Published
2021
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43. Clinico‐immunological outcomes of HCV‐cured cryoglobulinemia: Lower relapse rate with interferon‐based than interferon‐free therapy

Author

Colantuono, Stefania, primary, Marrapodi, Ramona, additional, Del Padre, Martina, additional, Collalti, Giulia, additional, Garzi, Giulia, additional, De Santis, Adriano, additional, Fiorilli, Massimo, additional, Basili, Stefania, additional, Visentini, Marcella, additional, and Casato, Milvia, additional

Published
2020
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46. Safety and effectiveness of biosimilar of Rituximab CT-P10 in the treatment of cryoglobulinemic vasculitis: the MARBLe study (Mixed cryoglobulinemiA Rituximab BiosimiLar)

Author

Vacchi, Caterina, primary, Visentini, Marcella, additional, Gragnani, Laura, additional, Fraticelli, Paolo, additional, Tavoni, Antonio, additional, Filippini, Davide, additional, Saccardo, Francesco, additional, Lauletta, Gianfranco, additional, Colantuono, Stefania, additional, Atzeni, Fabiola, additional, Pioltelli, Pietro, additional, Manfredi, Andreina, additional, Casato, Milvia, additional, Zignego, Anna Linda, additional, Monti, Giuseppe, additional, Pietrogrande, Maurizio, additional, Galli, Massimo, additional, and Sebastiani, Marco, additional

Published
2020
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49. Immunobiology of essential mixed cryoglobulinemia

Author

Colantuono, Stefania

Subjects
B cells, Essential mixed cryoglobulinemia, CD21low B cells, Essential mixed cryoglobulinemia, B cells, CD21low B cells, rheumatoid factor, rheumatoid factor
Published
2019

50. Prospective Italian real‐world study of mepolizumab in severe eosinophilic asthma validates retrospective outcome reports.

Author

Pini, Laura, Caruso, Cristiano, Colantuono, Stefania, Bagnasco, Diego, Maxwell, Aoife, Price, Robert G., Howarth, Peter, and Canonica, Giorgio Walter

Subjects
ASTHMA, MEDICAL personnel, PHYSICIANS, EOSINOPHILIA, EOSINOPHILIC granuloma, NEGATIVE binomial distribution
Abstract

Prospective Italian real-world study of mepolizumab in severe eosinophilic asthma validates retrospective outcome reports Current asthma guidelines inform about evidence-based approaches to optimize patient outcomes. Notably, the severity of asthma experienced by patients in both studies was very similar, and additionally patients had similar annual exacerbation rates (3.48 vs. 4.09 exacerbations/year) and similar hospitalization rates (0.44/year vs. 0.39/year). [Extracted from the article]

Published
2021
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