1,336 results on '"Coleman, Anne L"'
Search Results
2. A New Era of Ophthalmology Leadership? A Descriptive and Comparative Analysis of Ophthalmology Department Chairs in 2024
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Cohen, Samuel A., Tseng, Victoria L., Sridhar, Jayanth, and Coleman, Anne L.
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- 2025
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3. Comparison of Retinal Nerve Fiber Layer and Ganglion Cell Complex Rates of Change in Patients With Moderate to Advanced Glaucoma
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MOHAMMADI, MASSOOD, SU, ERICA, MOHAMMADZADEH, VAHID, BESHARATI, SAJAD, MARTINYAN, ARTHUR, COLEMAN, ANNE L., LAW, SIMON K., CAPRIOLI, JOSEPH, WEISS, ROBERT E., and NOURI-MAHDAVI, KOUROS
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- 2024
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4. Association of Open-Angle Glaucoma With Dementia in California Medicare Beneficiaries
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Topouzis, Nikolaos, Kitayama, Ken, Puran, Allan, Yu, Fei, Tseng, Victoria L., and Coleman, Anne L.
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- 2024
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5. Multivariate Longitudinal Modeling of Macular Ganglion Cell Complex: Spatiotemporal Correlations and Patterns of Longitudinal Change
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Mohammadzadeh, Vahid, Su, Erica, Shi, Lynn, Coleman, Anne L, Law, Simon K, Caprioli, Joseph, Weiss, Robert E, and Nouri-Mahdavi, Kouros
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Mathematical Sciences ,Biomedical and Clinical Sciences ,Statistics ,Ophthalmology and Optometry ,Eye Disease and Disorders of Vision ,Neurodegenerative ,Aging ,Clinical Research ,Bayesian Ganglion cell complex Hierarchical Longitudinal Macular OCT ,Bayesian ,GCC ,ganglion cell complex ,Ganglion cell complex ,Hierarchical ,Longitudinal ,Macular OCT ,PC ,principal component ,RNFL ,retinal nerve fiber layer ,SD ,standard deviation ,VF ,visual field - Abstract
PurposeTo investigate spatiotemporal correlations among ganglion cell complex (GCC) superpixel thickness measurements and explore underlying patterns of longitudinal change across the macular region.DesignLongitudinal cohort study.SubjectsOne hundred eleven eyes from 111 subjects from the Advanced Glaucoma Progression Study with ≥ 4 visits and ≥ 2 years of follow-up.MethodsWe further developed our proposed Bayesian hierarchical model for studying longitudinal GCC thickness changes across macular superpixels in a cohort of glaucoma patients. Global priors were introduced for macular superpixel parameters to combine data across superpixels and better estimate population slopes and intercepts.Main outcome measuresBayesian residual analysis to inspect cross-superpixel correlations for subject random effects and residuals. Principal component analysis (PCA) to explore underlying patterns of longitudinal macular change.ResultsAverage (standard deviation [SD]) follow-up and baseline 10-2 visual field mean deviation were 3.6 (0.4) years and -8.9 (5.9) dB, respectively. Superpixel-level random effects and residuals had the greatest correlations with nearest neighbors; correlations were higher in the superior than in the inferior region and strongest among random intercepts, followed by random slopes, residuals, and residual SDs. PCA of random intercepts showed a first large principal component (PC) across superpixels that approximated a global intercept, a second PC that contrasted the superior and inferior macula, and a third PC, contrasting inner and nasal superpixels with temporal and peripheral superpixels. PCs for slopes, residual SDs, and residuals were remarkably similar to those of random intercepts.ConclusionsIntroduction of cross-superpixel random intercepts and slopes is expected to improve estimation of population and subject parameters. Further model enhancement may be possible by including cross-superpixel random effects and correlations to address spatiotemporal relationships in longitudinal data sets.
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- 2022
6. Associations between Statin Use and Glaucoma in the All of Us Research Program
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Lee, Samuel Y., Paul, Megan E., Coleman, Anne L., Kitayama, Ken, Yu, Fei, Pan, Deyu, and Tseng, Victoria L.
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- 2024
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7. Racial and Ethnic Differences in the Prevalence and Treatment Patterns for Neovascular Glaucoma in the American Academy of Ophthalmology IRIS® Registry
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Tseng, Victoria L., Pan, Deyu, Kitayama, Ken, Yu, Fei, and Coleman, Anne L.
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- 2024
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8. Association Between Dietary Salt Intake and Open Angle Glaucoma in the Thessaloniki Eye Study
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Tseng, Victoria L, Topouzis, Fotis, Yu, Fei, Keskini, Christina, Pappas, Theofanis, Founti, Panayiota, Anastasopoulos, Eleftherios, Harris, Alon, Wilson, M Roy, and Coleman, Anne L
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Neurodegenerative ,Clinical Research ,Aging ,Cardiovascular ,Neurosciences ,Eye Disease and Disorders of Vision ,Nutrition ,Eye ,Aged ,Aged ,80 and over ,Antihypertensive Agents ,Cross-Sectional Studies ,Exfoliation Syndrome ,Female ,Glaucoma ,Open-Angle ,Humans ,Intraocular Pressure ,Male ,Risk Factors ,Sodium Chloride ,Dietary ,salt intake ,glaucoma ,antihypertensive ,thessaloniki ,population-based study ,Clinical Sciences ,Ophthalmology & Optometry - Abstract
PrcisIn the Thessaloniki Eye Study (TES) incidence phase population, frequent dietary salt intake was potentially associated with increased risk of open angle glaucoma in antihypertensive users.PurposeThe aim was to examine the association between dietary salt intake and glaucoma by antihypertensive use in the TES population.Materials and methodsThe study population included TES incidence phase participants. Dietary salt intake frequency was assessed by self-report. Outcomes included prevalence of any open angle glaucoma (OAG), primary open angle glaucoma (POAG), and pseudoexfoliation (PEX). Covariates included demographics, cardiovascular disease, migraines, diabetes, steroid use, smoking, history of cataract surgery, central corneal thickness, intraocular pressure, blood pressure, and antihypertensive use. Logistic regression was used to examine associations between frequency of salt intake and glaucoma, controlling for covariates and stratified by antihypertensive use.ResultsThe study included 1076 participants 80.5±4.4 years old, of whom 518 were female. There were 89/1076 (8.3%) participants with any OAG, 46/789 (5.8%) with POAG, and 287/1030 (27.9%) with PEX. In participants with antihypertensive use, frequent versus never salt intake was associated with increased risk of any OAG [adjusted odds ratio (aOR)=2.65, 95% confidence interval (CI)=1.12, 6.28; n=784] and POAG (aOR=3.59, 95% CI=1.16, 11.11; n=578) overall, and additionally in participants with diastolic blood pressure
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- 2022
9. Ganglion Cell Complex: The Optimal Measure for Detection of Structural Progression in the Macula.
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Mohammadzadeh, Vahid, Su, Erica, Rabiolo, Alessandro, Shi, Lynn, Zadeh, Sepideh Heydar, Law, Simon K, Coleman, Anne L, Caprioli, Joseph, Weiss, Robert E, and Nouri-Mahdavi, Kouros
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Retinal Ganglion Cells ,Macula Lutea ,Humans ,Glaucoma ,Tomography ,Optical Coherence ,Bayes Theorem ,Prospective Studies ,Intraocular Pressure ,Eye Disease and Disorders of Vision ,Clinical Research ,Neurodegenerative ,Eye ,Clinical Sciences ,Opthalmology and Optometry ,Public Health and Health Services ,Ophthalmology & Optometry - Abstract
PurposeTo test the hypothesis that macular ganglion cell complex (GCC) thickness from optical coherence tomography (OCT) provides a stronger change signal regardless of glaucoma severity compared with other macular measures.DesignProspective cohort study.MethodsEyes were from 112 patients with moderate to severe glaucoma at baseline from a tertiary glaucoma center. In each 3° × 3° macular superpixel, a hierarchical Bayesian random intercept and slope model with random residual variance was fit to longitudinal full macular thickness (FMT), outer retina layers, GCC, ganglion cell-inner plexiform layer (GCIPL), and ganglion cell layer (GCL) measurements. We estimated population- and individual-level slopes and intercepts. Proportions of substantial worsening and improving superpixel slopes were compared between layers and in superpixels with mild to moderate vs severe damage (total deviation of corresponding visual field location ≥ -8 vs < -8 dB).ResultsMean (SD) follow-up time and baseline 10-2 visual field mean deviation were 3.6 (0.4) years and -8.9 (5.9) dB, respectively. FMT displayed the highest proportion of significant negative slopes (1932/3519 [54.9%]), followed by GCC (1286/3519 [36.5%]), outer retina layers (1254/3519 [35.6%]), (GCIPL) (1075/3518 [30.6%]), and (GCL) (698/3518 [19.8%]). Inner macular measures detected less worsening in the severe glaucoma group; yet GCC (223/985 [22.6%]) identified the highest proportion (GCIPL: 183/985 [18.6%]; GCL: 106/985 [10.8%]). Proportions of positive rates were small and comparable among all measures.ConclusionsGCC is the optimal macular measure for detection of structural change in eyes with moderate to severe glaucoma. Although a higher proportion of worsening superpixels was observed for FMT, a large portion of FMT change could be attributed to changes in outer retina layers.
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- 2022
10. Disc Hemorrhages Are Associated With Localized Three-Dimensional Neuroretinal Rim Thickness Progression in Open-Angle Glaucoma
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Margeta, Milica A, Ratanawongphaibul, Kitiya, Tsikata, Edem, Zemplenyi, Michele, Ondeck, Courtney L, Kim, Janice, Coleman, Anne L, Yu, Fei, de Boer, Johannes F, and Chen, Teresa C
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Neurodegenerative ,Eye Disease and Disorders of Vision ,Neurosciences ,Aging ,Eye ,Glaucoma ,Open-Angle ,Hemorrhage ,Humans ,Intraocular Pressure ,Longitudinal Studies ,Nerve Fibers ,Optic Disk ,Prospective Studies ,Retinal Ganglion Cells ,Tomography ,Optical Coherence ,Clinical Sciences ,Opthalmology and Optometry ,Public Health and Health Services ,Ophthalmology & Optometry ,Ophthalmology and optometry - Abstract
PurposeTo evaluate the relationship between the occurrence of optic disc hemorrhages (DH) and glaucoma progression as determined by multiple glaucoma testing modalities.DesignProspective cohort study.MethodsA longitudinal study was undertaken of 124 open-angle glaucoma patients who had yearly disc photography, visual fields (VFs), spectral-domain optical coherence tomography (SD-OCT), retinal nerve fiber layer (RNFL) thickness scans, and optic nerve volume scans (Spectralis), all performed on the same day over a 5-year period. The minimum distance band (MDB) thickness, a 3-dimensional (3D) neuroretinal rim parameter, was calculated from optic nerve volume scans. Patients were classified as glaucoma progressors or glaucoma nonprogressors using event-based analysis.ResultsOf 124 open-angle glaucoma patients, 19 (15.3%) had 1 or more DHs on yearly disc photographs. Presence of a DH was associated with localized 3D neuroretinal rim thickness progression (superior MDB progression; odds ratio: 3.96; P = .04) but not with global or inferior MDB progression (P = .14 and .81, respectively), DP progression (P = .08), VF progression (P = .45), or RNFL global, inferior, or superior progression (P = .17, .26, and .76, respectively). In the majority of patients with MDB progression (14/17 or 82%), the progression was noted before or concurrently with the first instance of DH.ConclusionsGlaucoma progression detected by high-density 3D SD-OCT neuroretinal rim measurements preceded DH occurrence in the majority of patients. These findings support the hypothesis that DHs are indicators of ongoing glaucoma progression rather than discrete events that cause subsequent progression.
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- 2022
11. Adjunctive steroid therapy versus antibiotics alone for acute endophthalmitis after intraocular procedure
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Emami, Sara, Kitayama, Ken, and Coleman, Anne L
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Eye Disease and Disorders of Vision ,Clinical Research ,Clinical Trials and Supportive Activities ,Neurosciences ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Eye ,Anti-Bacterial Agents ,Dexamethasone ,Endophthalmitis ,Eye Diseases ,Humans ,Retinal Detachment ,Steroids ,Acute Disease ,Anti-Bacterial Agents [administration & dosage] [*therapeutic use] ,Cataract Extraction [*adverse eGects] ,Chemotherapy ,Adjuvant ,Dexamethasone [administration & dosage] [*therapeutic use] ,Endophthalmitis [*drug therapy] [etiology] ,Glucocorticoids [administration & dosage] [*therapeutic use] Intravitreal Injections [adverse eGects] ,Keratoplasty ,Penetrating [*adverse eGects] ,Postoperative Complications [*drug therapy] ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundEndophthalmitis refers to severe infection within the eye that involves the aqueous humor or vitreous humor, or both, and that threatens vision. Most cases of endophthalmitis are exogenous (i.e. due to inoculation of organisms from an outside source), and most exogenous endophthalmitis is acute and occurs after an intraocular procedure. The mainstay of treatment is emergent administration of broad-spectrum intravitreous antibiotics. Due to their anti-inflammatory effects, steroids in conjunction with antibiotics have been proposed as being beneficial in endophthalmitis management.ObjectivesTo assess the effects of antibiotics combined with steroids versus antibiotics alone for the treatment of acute endophthalmitis following intraocular surgery or intravitreous injection.Search methodsWe searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2021, Issue 8), MEDLINE Ovid (1946 to August 2021), Embase Ovid (1980 to August 2021), LILACS (Latin American and Caribbean Health Sciences Literature database) (1982 to August 2021), the ISRCTN registry; searched August 2021, ClinicalTrials.gov; searched August 2021, and the WHO International Clinical Trials Registry Platform; searched August 2021. We did not use any date or language restrictions in the electronic searches for trials.Selection criteriaWe included randomized controlled trials (RCTs) comparing the effectiveness of adjunctive steroids with antibiotics alone in the management of acute, clinically diagnosed endophthalmitis following intraocular surgery or intravitreous injection. We excluded trials with participants with endogenous endophthalmitis unless outcomes were reported by source of infection. We imposed no restrictions on the method or order of administration, dose, frequency, or duration of antibiotics and steroids.Data collection and analysisWe used standard Cochrane methodology, and graded the certainty of the body of evidence for six outcomes using the GRADE classification.Main resultsWe included four RCTs with a total of 264 eyes of 264 participants in this review update. The studies were conducted in South Africa, India, and the Netherlands. All studies used intravitreous dexamethasone for adjunctive steroid therapy and a combination of two intravitreous antibiotics that provided gram-positive and gram-negative coverage for the antibiotic therapy. We judged two trials to be at overall low risk of bias, and the other two studies to be at overall unclear risk of bias due to lack of reporting of study methods. Only one study was registered in a clinical trial register. While none of the included studies reported the primary outcome of complete resolution of endophthalmitis as defined in our protocol, one study reported combined anatomical and functional success (i.e. proportion of participants with intraocular pressure of at least 5 mmHg and visual acuity of at least 6/120). Very low certainty evidence suggested no difference in combined success when comparing adjunctive steroid to antibiotics alone (risk ratio (RR) 1.08, 95% confidence interval (CI) 0.80 to 1.45; 32 participants). Low certainty evidence from two studies suggested that adjunctive dexamethasone may result in having a good visual outcome (Snellen visual acuity 6/6 to 6/18) at 3 months compared with antibiotics alone (RR 1.95, 95% CI 1.05 to 3.60; 60 participants); however, the evidence was less conclusive at 12 months (RR 1.12, 95% CI 0.92 to 1.37; 2 studies; 195 participants; low certainty evidence). Investigators of one study reported improvement in visual acuity, but we could not estimate the effect of adjunctive steroid therapy because the study investigators did not provide any estimates of precision. Only one study examined intraocular pressure (IOP). The evidence suggests that adjunctive dexamethasone may reduce IOP slightly after 12 months of interventions (mean difference -1.90, 95% CI -3.78 to 0.07; 1 study; 167 participants; low certainty evidence). Three studies reported adverse events (retinal detachment, hypotony, proliferative vitreoretinopathy, seclusion of pupil, floaters, and pucker). The total numbers of adverse events were 14 out of 111 (12.6%) for those who received dexamethasone versus 12 out of 116 (10.3%) for those who did not. We could only perform a pooled analysis for the occurrence of retinal detachment: any difference between the two treatment groups was uncertain (RR 1.41, 95% CI 0.53 to 3.74; 227 participants; low certainty evidence). No study reported cost-related outcomes.Authors' conclusionsThe currently available evidence on the effectiveness of adjunctive steroid therapy versus antibiotics alone in the management of acute endophthalmitis after intraocular surgery is inadequate. We found no studies that had enrolled cases of acute endophthalmitis following intravitreous injection. A combined analysis of two studies suggests that use of adjunctive steroids may provide a higher chance of having a good visual outcome at three months than not using adjunctive steroids. However, considering that most of the confidence intervals crossed the null, and that this review was limited in scope and applicability to clinical practice, it is not possible to conclude whether the use of adjunctive steroids is effective at this time. Any future trials should examine whether adjunctive steroids may be useful in certain clinical settings such as type of causative organism or etiology. These studies should include outcomes that take patients' symptoms and clinical examination into account; report outcomes in a uniform and consistent manner; and follow up at short- and long-term intervals.
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- 2022
12. Netarsudil-Induced Corneal Flattening in a Child with Secondary Open-Angle Glaucoma
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Ganesh, Durga, Coleman, Anne L, Shibayama, Vivian P, and Tseng, Victoria L
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Neurosciences ,Eye Disease and Disorders of Vision ,Aging ,5.1 Pharmaceuticals ,Development of treatments and therapeutic interventions ,Eye ,Netarsudil ,Secondary open-angle glaucoma ,Corneal flattening ,Ophthalmology and optometry - Abstract
We report a case of a child with secondary open-angle glaucoma who developed 6.5 diopters (D) of corneal flattening upon the addition of Rhopressa (0.02% netarsudil dimesylate solution) eye drops to a preexisting treatment regimen of timolol and latanoprost. This change in corneal power reversed after netarsudil, a rho-kinase inhibitor, was discontinued and replaced with Vyzulta (0.024% latanoprostene bunod ophthalmic solution). The 4-year-old female patient presented with bilateral secondary open-angle glaucoma from Paired Box 6 (PAX6)-related aniridia, aphakia, and persistent fetal vasculature. She was started on netarsudil to treat elevated intraocular pressure (IOP) in her right eye, which was not adequately controlled by latanoprost and timolol. Over 4 months, she developed 6.5D of corneal flattening in her right eye. Netarsudil was stopped and the corneal flattening reversed. There is evidence to support the ability of rho kinase inhibitors to increase the healing of the corneal endothelium in addition to their intended IOP-lowering effects. Rho kinase inhibitors may increase cell proliferation and adhesion within the corneal endothelium, hence decreasing apoptosis and promoting cell preservation. If there was an excess of cell proliferation; however, this might induce stromal cells to abnormally secrete enzymes or proteins, such as TGFβ-induced proteins. This could result in corneal fibrosis, thereby flattening the cornea. Further investigation is required to explore this phenomenon and elucidate its mechanism of action. Corneal flattening may be considered as a potential side effect of the use of netarsudil, particularly in young pediatric patients.
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- 2022
13. Predictors of Glaucomatous Progression in Individuals with Small and Large Optic Discs
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Ho, Connie, Tseng, Victoria L., Grassi, Lourdes, Morales, Esteban, Yu, Fei, Coleman, Anne L., and Caprioli, Joseph
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- 2024
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14. Prevalence and Severity of Glaucoma in the California Medicare Population
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Tseng, Victoria L., Kitayama, Ken, Yu, Fei, and Coleman, Anne L.
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- 2024
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15. Earlier Detection of Glaucoma Progression Using High-Density 3-Dimensional Spectral-Domain OCT Optic Nerve Volume Scans
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Ratanawongphaibul, Kitiya, Tsikata, Edem, Zemplenyi, Michele, Lee, Hang, Margeta, Milica A, Ondeck, Courtney L, Kim, Janice, Pan, Billy X, Petrakos, Paul, Coleman, Anne L, Yu, Fei, de Boer, Johannes F, and Chen, Teresa C
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Aging ,Clinical Research ,Bioengineering ,Neurodegenerative ,Eye Disease and Disorders of Vision ,Neurosciences ,Eye ,Glaucoma ,Open-Angle ,Humans ,Longitudinal Studies ,Optic Nerve ,Prospective Studies ,Tomography ,Optical Coherence ,Glaucoma progression ,Neuroretinal rim ,Optic nerve ,Spectral-domain OCT ,Volume scans ,Ophthalmology and optometry - Abstract
PurposeTo compare onset times of glaucoma progression among different glaucoma tests: disc photography (DP), visual field (VF) testing, 2-dimensional (2D) retinal nerve fiber layer (RNFL) thickness, and 3-dimensional (3D) spectral-domain (SD) OCT neuroretinal rim measurements.DesignProspective, longitudinal cohort study.ParticipantsOne hundred twenty-four eyes of 124 patients with open-angle glaucoma.MethodsOver a 5-year period, 124 patients with open-angle glaucoma underwent yearly DP, VF testing, SD OCT RNFL thickness scans, and optic nerve volume scans (Spectralis; Heidelberg Engineering), all performed on the same day. From high-density optic nerve volume scans, custom-built software calculated the minimum distance band (MDB) thickness, a 3D neuroretinal rim parameter. Patients were classified as glaucoma progressors or nonglaucoma progressors using event-based analysis. Progression by DP and VF testing occurred when 3 masked glaucoma specialists unanimously concurred. Progression by RNFL and MDB thickness occurred if change of more than test-retest variability was observed. Kaplan-Meier curves were constructed to analyze time-to-progression data. Kappa Coefficients were used to measure agreement of progressing eyes among methods.Main outcome measuresTime to glaucoma progression among all 4 methods.ResultsGlobal MDB thickness detected glaucoma progression in the highest percentage of eyes (52.4%) compared with DP (16.1%; P < 0.001) and global RNFL thickness (15.3%; P < 0.001). Global MDB thickness detected glaucoma progression earlier than either DP (23 months vs. 44 months; P < 0.001) or global RNFL thickness (23 months vs. 33 months; P < 0.001). Among MDB progressing eyes, 46.2% were confirmed simultaneously or later by other conventional methods. Agreement of glaucoma-progressing eyes for all 4 methods in paired fashion were slight to fair (κ = 0.095-0.300).ConclusionsHigh-density 3D SD OCT neuroretinal rim measurements detected glaucoma progression approximately 1 to 2 years earlier compared with current clinically available structural tests (i.e., DP and 2D RNFL thickness measurements).
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- 2021
16. Detection of Longitudinal Ganglion Cell/Inner Plexiform Layer Change: Comparison of Two Spectral-Domain Optical Coherence Tomography Devices
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Mahmoudinezhad, Golnoush, Mohammadzadeh, Vahid, Amini, Navid, Delao, Kevin, Zhou, Bingnan, Hong, Tae, Zadeh, Sepideh Heydar, Morales, Esteban, Martinyan, Jack, Law, Simon K, Coleman, Anne L, Caprioli, Joseph, and Nouri-Mahdavi, Kouros
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Eye Disease and Disorders of Vision ,Neurodegenerative ,Aging ,Biomedical Imaging ,Eye ,Humans ,Intraocular Pressure ,Longitudinal Studies ,Nerve Fibers ,Retinal Ganglion Cells ,Tomography ,Optical Coherence ,Clinical Sciences ,Opthalmology and Optometry ,Public Health and Health Services ,Ophthalmology & Optometry ,Ophthalmology and optometry - Abstract
PurposeWe compared rates of change of macular ganglion cell/inner plexiform (GCIPL) thickness and proportion of worsening and improving rates from 2 optical coherence tomography (OCT) devices in a cohort of eyes with glaucoma.DesignLongitudinal cohort study.MethodsIn a tertiary glaucoma clinic we evaluated 68 glaucoma eyes with ≥2 years of follow-up and ≥4 OCT images. Macular volume scans from 2 OCT devices were exported, coregistered, and segmented. Global and sectoral GCIPL data from the central 4.8 × 4.0-mm region were extracted. GCIPL rates of change were estimated with linear regression. Permutation analyses were used to control specificity with the 2.5 percentile cutoff point used to define "true" worsening. Main outcome measures included differences in global/sectoral GCIPL rates of change between 2 OCT devices and the proportion of negative vs positive rates of change (P < .05).ResultsAverage (standard deviation) 24-2 visual field mean deviation, median (interquartile range) follow-up time, and number of OCT images were -9.4 (6.1) dB, 3.8 (3.3-4.2) years, and 6 (5-8), respectively. GCIPL rates of thinning from Spectralis OCT were faster (more negative) compared with Cirrus OCT; differences were significant in superonasal (P = .03) and superotemporal (P = .04) sectors. A higher proportion of significant negative rates was observed with Spectralis OCT both globally and in inferotemporal/superotemporal sectors (P < .04). Permutation analyses confirmed the higher proportion of global and sectoral negative rates of change with Spectralis OCT (P < .001).ConclusionsChanges in macular GCIPL were detected more frequently on Spectralis' longitudinal volume scans than those of Cirrus OCT. OCT devices are not interchangeable with regard to detection of macular structural progression.
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- 2021
17. Age at Glaucoma Diagnosis in Germline Myocilin Mutation Patients: Associations with Polymorphisms in Protein Stabilities.
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Tanji, Tarin, Cohen, Emily, Shen, Darrick, Zhang, Chi, Yu, Fei, Coleman, Anne L, and Zheng, Jie J
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Trabecular Meshwork ,Humans ,Glaucoma ,Glycoproteins ,Cytoskeletal Proteins ,Eye Proteins ,Age of Onset ,Germ-Line Mutation ,Polymorphism ,Single Nucleotide ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Middle Aged ,Female ,Male ,Protein Stability ,Endoplasmic Reticulum Stress ,endoplasmic reticulum stress ,intraocular pressure ,myocilin ,trabecular meshwork ,Neurodegenerative ,Genetics ,Aging ,Neurosciences ,Clinical Research ,Eye Disease and Disorders of Vision ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Eye - Abstract
Glaucoma is the leading cause of irreversible blindness worldwide, with elevated intraocular pressure (IOP) as the only known modifiable risk factor. Trabecular meshwork (TM)-inducible myocilin (the MYOC gene) was the first to be identified and linked to juvenile and primary open-angle glaucoma. It has been suggested that mutations in the MYOC gene and the aggregation of mutant myocilin in the endoplasmic reticulum (ER) of TM may cause ER stress, resulting in a reduced outflow of aqueous humor and an increase in IOP. We selected 20 MYOC mutations with experimentally determined melting temperatures of mutated myocilin proteins. We included 40 published studies with at least one glaucoma patient with one of these 20 MYOC mutations and information on age at glaucoma diagnosis. Based on data from 458 patients, we found that a statistically significant but weak correlation was present between age and melting temperature based on various assumptions for age. We therefore conclude that genetic analysis of MYOC mutations alone cannot be used to accurately predict age at glaucoma diagnosis. However, it might be an important prognostic factor combined with other clinical factors for critical and early detection of glaucoma.
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- 2021
18. Association between Food Insecurity and Chronic Eye Disease in the National Institutes of Health's All of Us Research Program
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Talebi, Ramin, Yu, Fei, Tseng, Victoria L., and Coleman, Anne L.
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- 2024
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19. The Association between Glaucoma Severity and Hip Fractures in California Medicare Beneficiaries
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Chatterjee, Sayan K., Talebi, Ramin, Kitayama, Ken, Young, Andrew G., Yu, Fei, Tseng, Victoria L., and Coleman, Anne L.
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- 2024
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20. Non-steroidal Anti-inflammatory Drug Use and Risk of Age-Related Macular Degeneration in the California Teachers Study
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Xu, Xiaoqing, Ritz, Beate, Coleman, Anne L, Liew, Zeyan, Deapen, Dennis, Lee, Eunjung, Bernstein, Leslie, Pinder, Rich, Marshall, Sarah F, and Heck, Julia E
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- 2021
21. The use of atropine for treatment of amblyopia using the OptumLabs Data Warehouse
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Pineles, Stacy L, Repka, Michael X, Yu, Fei, Velez, Federico G, Perez, Claudia, Sim, Danielle, and Coleman, Anne L
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Pediatric ,Brain Disorders ,Clinical Research ,Amblyopia ,Atropine ,Child ,Data Warehousing ,Follow-Up Studies ,Humans ,Mydriatics ,Sensory Deprivation ,Treatment Outcome ,Visual Acuity ,Clinical Sciences ,Ophthalmology & Optometry ,Clinical sciences ,Ophthalmology and optometry - Abstract
Atropine and patching are standard treatments for amblyopia, but the prevalence of atropine therapy in the United States is unknown. This study used the OptumLabs Data Warehouse to evaluate pharmacy claims for topical atropine to evaluate the frequency of its treatment for amblyopia and to compare demographic factors in cohorts of amblyopic children who were and were not prescribed atropine. Overall, 55.2% of amblyopic children were prescribed atropine more than once. The children who were prescribed atropine had a higher likelihood of living in geographic regions in the South or Midwest.
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- 2021
22. Adduction-Induced Strain on the Optic Nerve in Primary Open Angle Glaucoma at Normal Intraocular Pressure.
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Clark, Robert A, Suh, Soh Youn, Caprioli, Joseph, Giaconi, JoAnn A, Nouri-Mahdavi, Kouros, Law, Simon K, Bonelli, Laura, Coleman, Anne L, and Demer, Joseph L
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Orbit ,Optic Nerve ,Humans ,Glaucoma ,Open-Angle ,Magnetic Resonance Imaging ,Eye Movements ,Tonometry ,Ocular ,Prospective Studies ,Intraocular Pressure ,Adult ,Aged ,Middle Aged ,Female ,Male ,Biomechanical Phenomena ,Biomechanics ,normal tension glaucoma ,optic nerve ,optic nerve strain ,Neurosciences ,Biomedical Imaging ,Eye Disease and Disorders of Vision ,Neurodegenerative ,Ophthalmology & Optometry - Abstract
Purpose/aimThe optic nerve (ON) becomes taut during adduction beyond ~26° in healthy people and patients with primary open angle glaucoma (POAG), but only retracts the globe in POAG. We used magnetic resonance imaging (MRI) to investigate this difference.Materials and methodsMRI was obtained in 2-mm quasi-coronal planes in central gaze, and smaller (~23-25°) and larger (~30-31°) adduction and abduction in 21 controls and 12 POAG subjects whose intraocular pressure never exceeded 21 mmHg. ON cross-sections were analyzed from the globe to 10 mm posteriorly. Area centroids were used to calculate ON path lengths and changes in cross-sections to calculate elongation assuming volume conservation.ResultsFor both groups, ON path was nearly straight (
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- 2021
23. Estimating Ganglion Cell Complex Rates of Change With Bayesian Hierarchical Models.
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Mohammadzadeh, Vahid, Su, Erica, Heydar Zadeh, Sepideh, Law, Simon K, Coleman, Anne L, Caprioli, Joseph, Weiss, Robert E, and Nouri-Mahdavi, Kouros
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Retinal Ganglion Cells ,Humans ,Glaucoma ,Tomography ,Optical Coherence ,Bayes Theorem ,Intraocular Pressure ,Visual Fields ,Eye Disease and Disorders of Vision ,Aging ,Neurodegenerative ,optical coherence tomography ,OCT ,macula ,progression ,ganglion cell complex ,GCC ,longitudinal ,bayesian ,superpixels ,Biomedical Engineering ,Opthalmology and Optometry - Abstract
PurposeDevelop a hierarchical longitudinal regression model for estimating local rates of change of macular ganglion cell complex (GCC) measurements with optical coherence tomography (OCT).MethodsWe enrolled 112 eyes with four or more macular OCT images and ≥2 years of follow-up. GCC thickness measurements within central 6 × 6 superpixels were extracted from macular volume scans. We fit data from each superpixel separately with several hierarchical Bayesian random-effects models. Models were compared with the Watanabe-Akaike information criterion. For our preferred model, we estimated population and individual slopes and intercepts (baseline thickness) and their correlation.ResultsMean (SD) follow-up time and median (interquartile range) baseline 24-2 visual field mean deviation were 3.6 (0.4) years and -6.8 (-12.2 to -4.3) dB, respectively. The random intercepts and slopes model with random residual variance was the preferred model. While more individual and population negative slopes were observed in the paracentral and papillomacular superpixels, superpixels in the superotemporal and inferior regions displayed the highest correlation between baseline thickness and rates of change (r = -0.43 to -0.50 for the top five correlations).ConclusionsA Bayesian linear hierarchical model with random intercepts/slopes and random variances is an optimal initial model for estimating GCC slopes at population and individual levels. This novel model is an efficient method for estimating macular rates of change and probability of glaucoma progression locally.Translational relevanceThe proposed Bayesian hierarchical model can be applied to various macular outcomes from different OCT devices and to superpixels of variable sizes to estimate local rates of change and progression probability.
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- 2021
24. Parental Occupation and Risk of Childhood Retinoblastoma in Denmark
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Omidakhsh, Negar, Hansen, Johnni, Ritz, Beate, Coleman, Anne L, McKean-Cowdin, Roberta, Olsen, Jorn, and Heck, Julia E
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- 2021
25. Social Vulnerability, Prevalence of Glaucoma, and Incidence of Glaucoma Surgery in the California Medicare Population
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Tseng, Victoria L., Kitayama, Ken, Yu, Fei, Pan, Deyu, and Coleman, Anne L.
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- 2023
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26. Evaluating Discrepancies in Self-Reported Glaucoma and Electronic Health Records in the National Institutes of Health All of Us Database
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Paul, Megan E., Tseng, Victoria L., Kitayama, Ken, Yu, Fei, and Coleman, Anne L.
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- 2023
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27. Longitudinal Macular Structure–Function Relationships in Glaucoma
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Mohammadzadeh, Vahid, Rabiolo, Alessandro, Fu, Qiang, Morales, Esteban, Coleman, Anne L, Law, Simon K, Caprioli, Joseph, and Nouri-Mahdavi, Kouros
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Eye Disease and Disorders of Vision ,Aging ,Neurodegenerative ,Eye ,Adult ,Aged ,Aged ,80 and over ,Cross-Sectional Studies ,Female ,Follow-Up Studies ,Glaucoma ,Humans ,Intraocular Pressure ,Macula Lutea ,Male ,Middle Aged ,Nerve Fibers ,Optic Disk ,Prospective Studies ,Retinal Ganglion Cells ,Tomography ,Optical Coherence ,Visual Acuity ,Visual Fields ,Clinical Sciences ,Opthalmology and Optometry ,Public Health and Health Services ,Ophthalmology & Optometry ,Ophthalmology and optometry - Abstract
PurposeTo investigate the relationship between longitudinal changes in macular thickness measurements from OCT and changes in central visual field (VF) in patients with glaucoma with central or advanced damage at baseline.DesignLongitudinal cohort study.ParticipantsA total of 116 eyes with ≥3 years of follow-up and ≥5 macular OCT images and central 10° VF tests were selected.MethodsOCT superpixels and VF locations were matched correcting for retinal ganglion cell (RGC) displacement. Superpixel thickness and VF total deviation (TD) values, in both logarithmic and linear scales, were averaged within 3 eccentricities (3.4°, 5.6°, and 6.8°) and superior and inferior hemiretinas and hemifields. We estimated pointwise TD rates of change and rates of change at superpixels for full macular thickness (FMT), ganglion cell complex (GCC), ganglion cell inner plexiform layer (GCIPL), and ganglion cell layer (GCL). Correlation of structure-function (SF) rates of change was investigated with parametric tests. We compared the proportion of worsening and positive slopes for superpixels and VF test locations (negative vs. positive rates of change with P < 0.05) throughout the follow-up period. Permutation analyses were used to control specificity.Main outcome measuresMagnitude of correlation between structural and functional rates of change and proportion of worsening and positive slopes as a function of follow-up time.ResultsThe median (interquartile range) follow-up and number of exams were 4.2 (3.7-4.6) years and 8 (7-9), respectively. The highest correlation of change rates was observed at 3.4° and 5.6° eccentricities (r = 0.24, 0.41, 0.40, and 0.40 for FMT, GCC, GCIPL, and GCL for 3.4° eccentricity and r = 0.28, 0.32, 0.31, and 0.32 for FMT, GCC, GCIPL, and GCL for 5.6° eccentricity, respectively). Although GCC measures demonstrated the highest overall longitudinal SF correlations, the differences were not statistically significant. Significant structural worsening was more frequently detected than functional deterioration at 3- and 5-year time points (P < 0.025). Permutation analyses also confirmed this finding.ConclusionsCorrelations between central structural and functional rates of change were weak to fair in this cohort. Structural changes were detected more frequently than functional changes. Measurements of both structure and function are required for optimal detection of central progression.
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- 2020
28. Orbital Fat Volume After Treatment with Topical Prostaglandin Agonists
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Chen, Jessica Y, Le, Alan, Caprioli, Joseph, Giaconi, JoAnn A, Nouri-Mahdavi, Kouros, Law, Simon K, Bonelli, Laura, Coleman, Anne L, and Demer, Joseph L
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Neurosciences ,Eye Disease and Disorders of Vision ,Clinical Research ,Neurodegenerative ,Aging ,Adipose Tissue ,Administration ,Topical ,Aged ,Aged ,80 and over ,Female ,Glaucoma ,Open-Angle ,Humans ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Orbit ,Organ Size ,Prostaglandins ,Synthetic ,orbit ,prostaglandins ,magnetic resonance imaging ,Biological Sciences ,Medical and Health Sciences ,Ophthalmology & Optometry - Abstract
PurposeTopical prostaglandin analogs (PGAs) are common treatment for primary open-angle glaucoma (POAG) but reportedly may cause adnexal fat atrophy. We asked if patients with POAG treated with PGAs have abnormalities in orbital fat volume (OFV).MethodsWe studied 23 subjects with POAG who had never experienced intraocular pressure (IOP) exceeding 21 mm Hg and were treated long term with PGAs, in comparison with 21 age-matched controls. Orbital volume, non-fat orbital tissue volume, and OFV were measured using high-resolution magnetic resonance imaging.ResultsSubjects with POAG had been treated with PGAs for 39 ± 19 months (SD) and were all treated within the 4 months preceding study. In the region from trochlea to orbital apex, OFV in POAG was significantly less at 9.8 ± 1.9 mL than in the control subjects at 11.1 ± 1.3 mL (P = 0.019). However, between the globe-optic nerve junction (GONJ) and trochlea, OFV was similar in both groups. Width and cross sectional area of the bony orbit were significantly smaller in POAG than in controls (P < 0.0001). Posterior to the GONJ, the average orbital cross-sectional area was 68.2 mm2 smaller, and the orbital width averaged 1.5 mm smaller throughout the orbit, in patients with POAG than in controls.ConclusionsPatients with POAG who have been treated with PGAs have lower overall OFV than controls, but OFV in the anterior orbit is similar in both groups. Lower overall OFV in POAG may be a primary association of this disorder with a horizontally narrower bony orbit, which may be a risk factor for POAG at nonelevated IOPs.
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- 2020
29. Optic Nerve Traction During Adduction in Open Angle Glaucoma with Normal versus Elevated Intraocular Pressure
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Demer, Joseph L, Clark, Robert A, Suh, Soh Youn, Giaconi, Joann A, Nouri-Mahdavi, Kouros, Law, Simon K, Bonelli, Laura, Coleman, Anne L, and Caprioli, Joseph
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Eye Disease and Disorders of Vision ,Neurodegenerative ,Neurosciences ,Aging ,Adult ,Aged ,Eye Movements ,Female ,Glaucoma ,Open-Angle ,Humans ,Intraocular Pressure ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Oculomotor Muscles ,Optic Nerve ,Optic Nerve Diseases ,Prospective Studies ,Tomography ,Optical Coherence ,Tonometry ,Ocular ,Visual Fields ,Young Adult ,eye movement ,glaucoma ,optic nerve ,Ophthalmology & Optometry - Abstract
Purpose/Aim: We used magnetic resonance imaging (MRI) to investigate effects of intraocular pressure (IOP), race, and other factors on optic nerve (ON) traction in adduction, a phenomenon proposed as neuropathic in open angle glaucoma (OAG).Materials and Methods: Thirty-five patients with OAG (26 with maximal untreated IOP ≤21 mmHg, 9 with IOP >21mmHg) and 48 controls underwent axial and quasi-coronal MRI in central gaze and large (27-33°) abduction and adduction. Some underwent MRI at smaller ductions (21-28°). Effects of presence vs. absence of OAG; within OAG whether maximum IOP level was ≤21 mmHg vs. >21 mmHg; adduction angle; race; age; and gender on ON path length and globe translation were analyzed using generalized estimating equations to account for possible intereye correlations of individual subjects.Results: Average visual field mean deviation (±standard error of mean, SEM) was -8.2 ± 1.2 dB in OAG with normal IOP, and -6.1 ± 1.4 in high IOP. In central gaze, ON path in OAG was significantly more redundant than in controls but in both groups the ON became significantly and almost equally straighter in small (~21°) or large (~27°) adduction than in central gaze. With progressive adduction only, globes retracted in OAG (P
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- 2020
30. Comparison of Methods to Detect and Measure Glaucomatous Visual Field Progression.
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Rabiolo, Alessandro, Morales, Esteban, Mohamed, Lilian, Capistrano, Vicente, Kim, Ji Hyun, Afifi, Abdelmonem, Yu, Fei, Coleman, Anne L, Nouri-Mahdavi, Kouros, and Caprioli, Joseph
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Advanced Glaucoma Intervention Study ,Collaborative Initial Glaucoma Treatment Study ,glaucoma rate index ,guided progression analysis ,mean deviation ,perimetry ,permutation of pointwise linear regression ,visual field rate ,visual field simulation ,Biomedical Engineering ,Opthalmology and Optometry - Abstract
Purpose:To compare methods to assess visual field (VF) progression in glaucoma. Methods:4,950 VFs of 253 primary open angle-glaucoma patients were evaluated for progression with the following methods: clinical evaluation, guided progression analysis (GPA), mean deviation (MD), and visual field index (VFI) rates, Advanced Glaucoma Intervention Study (AGIS) and Collaborative Initial Glaucoma Treatment Study (CIGTS) scores, pointwise linear regression (PLR), permutation of PLR (PoPLR), and glaucoma rate index (GRI). A separate simulated series of longitudinal VFs was assessed with all methods except for GPA and clinical evaluation. Results:The average (±SD) age of the patients at baseline was 65.4 (±11.5) years. The average (±SD) follow-up was 11.8 (±4.6) years, and the mean (±SD) number of VFs was 16.8 (±7.0). Proportion of series detected as progressing was 65% for PoPLR, 58% for GRI, 41% for GPA, 40% for PLR, 36% for CIGTS, 35% for clinicians, 31% for MD rate, 29% for AGIS, and 22% for VFI rate. Median times to detection of progression were 7.3 years for PoPLR, 7.5 years for GRI, 11 years for clinicians, 14 years for GPA, 16 years for PLR, 17 years for CIGTS, 19 years for AGIS, and more than 20 years for MD and VFI rates. In simulated VF series, GRI had the highest partial area under the receiver operator characteristic curve (0.040) to distinguish between glaucoma progression and aging/cataract decay, followed by VFI rate (0.028), MD rate (0.024), and PoPLR (0.006). Conclusions:GRI and PoPLR showed the highest proportion of series detected as progressing and shortest times to progression detection. GRI exhibited the best ability to detect progression in the simulated VF series. Translational Relevance:Knowledge of the properties of every method would allow tailoring application in both clinical and research settings.
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- 2019
31. Cyclodestructive procedures for refractory glaucoma
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Chen, Monica F, Kim, Carole H, and Coleman, Anne L
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Neurosciences ,Eye Disease and Disorders of Vision ,Clinical Trials and Supportive Activities ,Clinical Research ,Patient Safety ,6.3 Medical devices ,Evaluation of treatments and therapeutic interventions ,Eye ,Aqueous Humor ,Ciliary Body ,Endoscopy ,Glaucoma ,Glaucoma Drainage Implants ,Humans ,Intraocular Pressure ,Laser Coagulation ,Lasers ,Solid-State ,Randomized Controlled Trials as Topic ,Visual Acuity ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundCyclodestructive procedures are often used in patients with refractory glaucoma who have failed to achieve lower intraocular pressure (IOP) from filtration procedures and maximal medical therapy. Destruction of the ciliary body helps to lower IOP by reducing aqueous humor formation. Of the many types of cyclodestructive procedures, laser cyclophotocoagulation (CPC) has become the most common surgical method for reducing aqueous inflow. Options for CPC are wide-ranging: they can be performed using a neodymium:yttrium-aluminum-garnet (Nd:YAG) or diode laser and laser energy can be delivered by either the contact or non-contact method. Another cyclodestructive procedure is endoscopic cyclophotocoagulation (ECP), which the ophthalmologist can use selectively to target the ciliary epithelium and ablate ciliary body tissue. There is debate regarding which cyclodestructive method is best and how they compare to other glaucoma surgeries.ObjectivesTo assess the relative effectiveness and safety of cyclodestructive procedures compared with other procedures in people with refractory glaucoma of any type and to assess the relative effectiveness and safety of individual cyclodestructive procedures compared with each other.Search methodsWe searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2018, Issue 9); Ovid MEDLINE; Embase.com; PubMed; LILACS BIREME; ClinicalTrials.gov and the WHO ICTRP. The date of the search was 21 September 2018.Selection criteriaWe included randomized controlled trials or quasi-randomized trials in which participants underwent a secondary procedure for refractory glaucoma. We included trials with any laser type, route of administration, and laser settings. The primary comparison was any cyclodestructive procedure versus another glaucoma treatment, and the secondary comparisons were individual cyclodestructive procedures versus another cyclodestructive procedure.Data collection and analysisTwo review authors independently reviewed the titles and abstracts from the database searches, and after retrieving the full-text reports of those that were potentially relevant, classified the full-text articles as included or excluded. Two review authors independently extracted data from the included studies and assessed the risk of bias. Discrepancies were resolved by discussion or by consultation with a third review author when necessary.Main resultsWe included five trials reporting data for 330 eyes (326 participants). One study to had a low risk of bias for most domains and the other studies had an overall unclear risk of bias. This review includes four different comparisons: 1) ECP versus Ahmed implant, 2) micropulse CPC versus continuous-wave CPC; 3) CPC with a diode versus Nd:YAG laser; and 4) CPC with an Nd:YAG laser emitting 8J versus 4J.No study reported data for our primary outcome, change from baseline in pain severity as reported by the participant or change in number of pain medications.For our primary comparison, we included one trial that compared ECP with the Ahmed implant. At 12-month follow-up, the mean difference (MD) in IOPs between groups was -1.14 mmHg (95% confidence interval (CI) -4.21 to 1.93; 58 participants; low-certainty evidence (LCE)). At 24 months postintervention, we found very LCE suggesting that visual acuity may be better among participants in the ECP group than in the Ahmed implant group (MD -0.24 logMAR, 95% CI -0.52 to 0.04; 54 participants), and the difference in the mean number of glaucoma medications used by participants in each group was unclear (MD -0.50, 95% CI -1.17 to 0.17; 54 participants; very LCE). Reported adverse events in the ECP group (34 participants) were one case each of hypotony, phthisis bulbi, retinal detachment, and choroidal detachment; in the Ahmed implant group (34 participants) there was one case of endophthalmitis, two cases of retinal detachment, and six cases of choroidal detachment.Three types of comparisons from four included studies provided data for our secondary comparisons. In the study that compared micropulse with continuous-wave CPC, median IOP was reported to be similar between the two groups at all time points. At 18 months postintervention, the median number of IOP-lowering medications was reduced from two to one in both groups. One participant in the micropulse and two in the continuous group exhibited worsened visual acuity. One case of prolonged inflammation was seen in the micropulse group (23 participants). Seven cases of prolonged inflammation, five cases of hypotony, and one case of phthisis bulbi were seen in the continuous group (23 participants).Two studies compared CPC using a semiconductor diode versus an Nd:YAG laser. At 12 months postintervention, the MD in IOP was 1.02 mmHg (95% CI -1.49 to 3.53) in one study (LCE). The second study did not report mean IOP beyond three months of follow-up. Neither study reported the mean change in best-corrected visual acuity or number of glaucoma medications. Both studies reported hypotony as an adverse event in three participants in each study.One study compared different energy settings of the same Nd:YAG laser. At 12-month follow-up, visual acuity was unchanged or improved in 21 of 33 participants in the 8J group and 20 of 27 participants in the 4J group (risk ratio 0.86, 95% CI 0.61 to 1.21; very LCE). More participants in the 8J group reduced the number of medications taken compared with the 4J group (RR 1.49, 95% CI 0.76 to 2.91; 50 participants; very low-certainty evidence). The presence of fibrin or hyphema were seen in five participants who received 8J and none who received 4J. There was a severe anterior chamber reaction in 11 of 26 (42%) participants who received 8J of energy and 2 of 21 (10%) participants who received 4J of energy.Authors' conclusionsEvidence from five studies included in this review was inconclusive as to whether cyclodestructive procedures for refractory glaucoma result in better outcomes and fewer complications than other glaucoma treatments, and whether one type of cyclodestructive procedure is better than another. The most commonly reported adverse events across all five studies were hypotony and phthisis bulbi. Large, well-designed randomized controlled trials are needed. Patient-reported outcomes such as pain and quality of life should be considered as primary outcomes or important secondary outcomes of future trials.
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- 2019
32. Disparities in Vision Health and Eye Care
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Aguwa, Ugochi, Alabiad, Chrisfouad, Briceno, Cesar, Capo, Hilda, Contreras, Melissa, Edmond, Jane, Ervin, Ann-Margret, Fountain, Tamara, Friedman, David, Gao, James, Gordon, Lynn, Harewood, Joy, Kitayama, Ken, Knight, O’Rese, Lee, Aaron, Lee, Paul, Legault, Gary, Nwanyanwu, Kristen, Olivier, Mildred, Perez-Gonzalez, Cesar, Randolph, Jessica, Ross, Ahmara, Shoge, Ruth, Solomon, Sharon, Williams, Basil, Woreta, Fasika, Wright, Charles, Zebardast, Nazlee, Elam, Angela R., Tseng, Victoria L., Rodriguez, Tannia M., Mike, Elise V., Warren, Alexis K., and Coleman, Anne L.
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- 2022
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33. An IRIS Registry-Based Assessment of Primary Open-Angle Glaucoma Practice Patterns in Academic Versus Nonacademic Settings
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Skuta, Gregory L., Ding, Kai, Lum, Flora, and Coleman, Anne L.
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- 2022
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34. Association of Mood Disorders, Substance Abuse, and Anxiety Disorders in Children and Teens With Serious Structural Eye Diseases
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Meer, Elana A., Lee, Yoon H., Repka, Michael X., Borlik, Marcy F., Velez, Federico G., Perez, Claudia, Yu, Fei, Coleman, Anne L., and Pineles, Stacy L.
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- 2022
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35. Population-Level Associations Between Visual Impairment and Functional Difficulties in California.
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Wang, Karissa M., Coleman, Anne L., Pan, Deyu, Yu, Fei, and Tseng, Victoria L.
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VISION disorders , *AMERICAN Community Survey , *LOW vision , *RACE , *HEALTH insurance , *ETHNICITY - Abstract
Purpose: The prevalence of visual impairment is increasing, and there is a need to understand the functional implications. Using the American Community Survey (ACS) data, this study examined the relationship between visual impairment and functional difficulties in California. Methods: Using the 2010–2014 and 2015–2019 ACS 5-year estimates from the U.S. Census, data were obtained for visual impairment and functional difficulties including hearing, cognitive, ambulatory, self-care, and independent living difficulties. The prevalence of vision impairment and each functional difficulty was calculated on the Medical Service Study Area (MSSA) level in California. Unadjusted and adjusted linear regression models were performed to estimate the association between visual impairment and each functional difficulty, adjusting for age, sex, race and ethnicity, education level, English-speaking ability, poverty status, health insurance status, and urbanity of residence location. Results: The prevalence of visual impairment in California was 2.3% (659,502 of 28,794,572) in 2010–2014 and 2.3% (709,353 of 30,231,767) in 2015–2019 among the population ≥ 18 years old. There were statistically significant associations between the prevalence of vision impairment and increased prevalence of all functional difficulties, with the most positive correlation observed with ambulatory difficulty (slope estimate 0.58 ± 0.072 for 2010–2014 and 0.78 ± 0.082 for 2015–2019 for ambulatory difficulty). Conclusions: There may be population-level impacts of functional consequences from vision impairment, suggesting the need for neighborhood-level investigation and policy-based interventions to address the burden of vision impairment on the population level. [ABSTRACT FROM AUTHOR]
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- 2025
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36. Occupational exposures and age-related cataract: A review.
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Iwundu, Chisom N., Yin, Cheng, Coleman, Anne L., Hansen, Johnni, Kwon, Junhyeon, and Heck, Julia E.
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WELDING fumes ,POLYCYCLIC aromatic hydrocarbons ,ULTRAVIOLET radiation ,IONIZING radiation ,VISION disorders - Abstract
Occupational exposures comprise of a broad range of factors in constant and direct contact with the ocular surface. Cataract, a leading cause of visual impairment globally, has been associated with various occupational exposures. This review critically examines existing literature on the relationship between occupational exposures and cataract development. We aim to synthesize findings from studies exploring the impact of occupational factors such as ultraviolet (UV) radiation, ionizing radiation, welding fumes, polyaromatic hydrocarbons, tobacco dust, and other elements on the prevalence and incidence of cataract among exposed populations. In our review, certain exposures, such as UV radiation, demonstrated strong evidence regarding their association with cataract development, while others presented suggestive evidence. Hence, further studies are needed to better understand exposures of greatest concern, which can subsequently inform regulations pertaining to occupational exposures in work environments. [ABSTRACT FROM AUTHOR]
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- 2024
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37. An Eye on Gender Equality: A Review of the Evolving Role and Representation of Women in Ophthalmology
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Gill, Hannah K., Niederer, Rachael L., Shriver, Erin M., Gordon, Lynn K., Coleman, Anne L., and Danesh-Meyer, Helen V.
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- 2022
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38. Strabismus Surgery Decreases the Risk of Injuries in Pediatric Patients in the OptumLabs Data Warehouse
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Pineles, Stacy L., Repka, Michael X., Yu, Fei, Velez, Federico G., Perez, Claudia, Sim, Danielle, and Coleman, Anne L.
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- 2022
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39. Association Between E-Cigarette Use and Visual Impairment in the United States
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Golla, Abhinav, Chen, Angela, Tseng, Victoria L., Lee, Samuel Y., Pan, Deyu, Yu, Fei, and Coleman, Anne L.
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- 2022
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40. A Method to Measure the Rate of Glaucomatous Visual Field Change
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Caprioli, Joseph, Mohamed, Lilian, Morales, Esteban, Rabiolo, Alessandro, Sears, Nathaniel, Pradtana, Hirunpatravong, Alizadeh, Reza, Yu, Fei, Afifi, Abdelmonem A, Coleman, Anne L, and Nouri-Mahdavi, Kouros
- Subjects
Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Eye Disease and Disorders of Vision ,Clinical Research ,Aging ,Detection ,screening and diagnosis ,4.1 Discovery and preclinical testing of markers and technologies ,Glaucoma Rate Index ,pointwise exponential progression ,glaucomatous perimetric progression ,visual field ,Biomedical Engineering ,Opthalmology and Optometry ,Ophthalmology and optometry - Abstract
PurposeTo develop a method to measure the rate of glaucomatous visual field (VF) deterioration and to identify fast progressors.MethodsRetrospective, longitudinal, observational study of 8486 eyes of 4610 glaucomatous patients with ≥6 VFs and ≥3 years of follow-up. A Glaucoma Rate Index (GRI) was calculated. VF locations were partitioned into exponential decay or exponential improvement models. A pointwise rate of change (PRC) was estimated with an exponential fit and expressed as the percent/year change of the age- and location-matched normal perimetric range, presented as a spatially conserved VF map. PRCs were summed and normalized with boundary rates set by simulated decaying and improving VF series on a scale of -100 to +100, respectively.ResultsA total of 89,704 VF examinations with 425,039 test location series was used. Median follow-up and number of VFs/eye were 9.7 years and 9 VFs, respectively. Initial and final mean deviations (±SD) were -4.2 (±5.2) and -5.7 (±6.4) dB. The proportions of test locations designated as decayed, improved, and unchanged were 13%, 4%, and 83%, respectively. Mean PRCs for decay, improvement, and no change were -3.7 (±4.7)%/y, 2.5 (±2.6)%/y, and -0.5 (±2.1)%/y, respectively. The number of eyes with negative and positive GRIs was 5802 (68%) and 2390 eyes (28%), respectively. The proportion of eyes defined as fast progressors was 6.8%.ConclusionsGRI provides a robust measure of glaucomatous VF change, operates without discontinuity over the entire perimetric range, and can be used to identify fast progressors.Translational relevanceThis study describes a novel method that can help the clinician to determine VF progression.
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- 2018
41. The use of bevacizumab and ranibizumab for branch retinal vein occlusion in medicare beneficiaries
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Wu, Annie M, Wu, Connie M, Greenberg, Paul B, Yu, Fei, Lum, Flora, and Coleman, Anne L
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Neurosciences ,Clinical Research ,Health Services ,Anti-VEGF ,BVO ,Branch retinal vein occlusion ,Geographic variation ,Medicare - Abstract
PurposeTo describe the frequency and variation of intravitreal bevacizumab and ranibizumab use for branch retinal vein occlusion (BVO) in the United States (US).MethodsWe obtained a 5% random sample of Medicare beneficiaries from the Medicare Denominator and Physician/Supplier Part B claims files from 2010 to 2013 and identified all beneficiaries with an ICD-9-CM code for branch retinal vein occlusion (BVO, 362.36). Patient age, gender, race, state of residence and Charlson Comorbidity Index (CCI) scores were collected. Healthcare Common Procedure Coding System (HSCPS) codes for bevacizumab (J3590, J9035, and J3490) and for ranibizumab (J2778) were used to identify the mode of treatment for each patient. Patients who met the following criteria were excluded from this study: (1) under 65 years of age; (2) residence outside of the 50 United States or the District of Columbia; (3) no Part-B coverage or with HMO coverage that was not processed by Centers for Medicare & Medicaid Services (CMS); (4) concomitant diagnosis of diabetic edema (ICD-9: 362.07) or central retinal vein occlusion (ICD-9: 362.35); and (5) received both or none of the above two treatments. Geographic variation was examined by comparing injection frequencies across the nine US census divisions using Chi-squared analysis.ResultsDuring 2010-2013, a majority of the 3944 BVO patients who met the inclusion criteria received bevacizumab compared to ranibizumab (76.7% vs 23.3%). Most patients were aged 75-79 (22.0%) or 80-84 (22.0%), female (61.5%), white (88.3%), and had a CCI score of 1-2 (39.8%). The frequencies of bevacizumab and ranibizumab injections for BVO varied significantly between the US census divisions (p
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- 2018
42. Disc Hemorrhages Are Associated With Localized Three-Dimensional Neuroretinal Rim Thickness Progression in Open-Angle Glaucoma
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Margeta, Milica A., Ratanawongphaibul, Kitiya, Tsikata, Edem, Zemplenyi, Michele, Ondeck, Courtney L., Kim, Janice, Coleman, Anne L., Yu, Fei, de Boer, Johannes F., and Chen, Teresa C.
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- 2022
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43. Biomarkers of Maternal Smoking and the Risk of Retinoblastoma in Offspring
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He, Di, Huang, Xiwen, Uppal, Karan, Coleman, Anne L, Walker, Douglas D, Ritz, Beate, Jones, Dean P, and Heck, Julia E
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- 2022
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44. Ophthalmic Immune-Related Adverse Events after Anti-CTLA-4 or PD-1 Therapy Recorded in the American Academy of Ophthalmology Intelligent Research in Sight Registry
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Sun, Michel M., Kelly, Scott P., Mylavarapu, BS, Apoorva L., Holland, Gary N., Coleman, Anne L., Yu, Fei, Hsu, MS, Stephen, Lum, Flora, and Gordon, Lynn K.
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- 2021
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45. Comparison of Outcomes between Endoscopic and Transcleral Cyclophotocoagulation.
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Beardsley, Robert, Law, Simon K, Caprioli, Joseph, Coleman, Anne L, Nouri-Mahdavi, Kouros, Hubschman, Jean-Pierre, Schwartz, Steven D, and Giaconi, JoAnn A
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cycloablation ,cyclodestruction ,cyclophotocoagulation ,endoscopic cyclophotocoagulation ,transcleral cyclophotocoagulation - Abstract
Importance: Traditionally cyclophotocoagulation has been reserved as a treatment of last resort for eyes with advanced stage glaucoma, but increasingly it is offered to eyes with less severe disease. Endoscopic approaches in particular are utilized in increasing numbers of patients despite only a small number of publications on its results. Objective: The purpose of this study was to compare the efficacy and safety of endoscopic and transcleral cyclophotocoagulation (ECP and TCP) procedures in eyes with refractory glaucomas. Design, Setting, and Participants: A chart review was performed on consecutive patients who underwent ECP and TCP at a tertiary ophthalmology care center between January 2000 and December 2010. Cases with fewer than 3 months of follow-up or that had concurrent pressure reducing procedures were excluded. The main outcome measures examined were intraocular pressure (IOP), number of glaucoma medications, best corrected visual acuity (BCVA), additional glaucoma procedure required, and complications. Main Outcomes and Measures: Forty-two eyes (42 patients) that underwent ECP and forty-four eyes (44 patients) that underwent TCP were identified. The TCP group had a statistically higher mean age (71.2 ± 16.7 vs. 58.1 ± 22.9 years, respectively), larger proportion of neovascular glaucoma (40.9% vs. 16.7%), worse initial BCVA (logMAR 2.86 vs. 1.81), and higher preoperative IOP (45.3 vs. 26.6 mmHg) than the ECP group. At 12 months follow-up, the mean IOP difference between groups was not statistically significant, although the change in IOP from baseline to 12 months was greater for the TCP group (p = 0.006). The rates of progression to no light perception (NLP) and phthisis bulbi were significantly higher amongst TCP eyes than ECP eyes (27.2% vs. 4.8%, p = 0.017, and 20.5% vs. 0%, p = 0.003, respectively). Of these eyes that progressed, a majority had neovascular glaucoma (NVG). Corneal decompensation was the most frequent complication following ECP (11.9%). Conclusions and Relevance: In patients with preoperative BCVA of 20/400 or better, overall complication rates (cystoid macular edema, exudative retinal detachment, inflammation, cornea decompensation) were higher after ECP than with TCP. In refractory glaucomas in a real world setting (not a trial), TCP was more frequently used in ischemic eyes. TCP was associated with a higher rate of progression to phthisis bulbi and loss of light perception than ECP. However, ECP was associated with a clinically significant rate of corneal decompensation. These outcomes likely were related to the severity of underlying ocular diseases found in these eyes.
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- 2017
46. Magnetic Resonance Imaging of Optic Nerve Traction During Adduction in Primary Open-Angle Glaucoma With Normal Intraocular Pressure
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Demer, Joseph L, Clark, Robert A, Suh, Soh Youn, Giaconi, JoAnn A, Nouri-Mahdavi, Kouros, Law, Simon K, Bonelli, Laura, Coleman, Anne L, and Caprioli, Joseph
- Subjects
Neurodegenerative ,Aging ,Eye Disease and Disorders of Vision ,Neurosciences ,Adult ,Aged ,Case-Control Studies ,Female ,Glaucoma ,Open-Angle ,Humans ,Intraocular Pressure ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Optic Nerve ,Optic Nerve Diseases ,Prospective Studies ,Visual Fields ,Young Adult ,biomechanics ,orbit ,extraocular muscle ,magnetic resonance imaging ,Biological Sciences ,Medical and Health Sciences ,Ophthalmology & Optometry - Abstract
PurposeWe used magnetic resonance imaging (MRI) to ascertain effects of optic nerve (ON) traction in adduction, a phenomenon proposed as neuropathic in primary open-angle glaucoma (POAG).MethodsSeventeen patients with POAG and maximal IOP ≤ 20 mm Hg, and 31 controls underwent MRI in central gaze and 20° to 30° abduction and adduction. Optic nerve and sheath area centroids permitted computation of midorbital lengths versus minimum paths.ResultsAverage mean deviation (±SEM) was -8.2 ± 1.2 dB in the 15 patients with POAG having interpretable perimetry. In central gaze, ON path length in POAG was significantly more redundant (104.5 ± 0.4% of geometric minimum) than in controls (102.9 ± 0.4%, P = 2.96 × 10-4). In both groups the ON became significantly straighter in adduction (28.6 ± 0.8° in POAG, 26.8 ± 1.1° in controls) than central gaze and abduction. In adduction, the ON in POAG straightened to 102.0% ± 0.2% of minimum path length versus 104.5% ± 0.4% in central gaze (P = 5.7 × 10-7), compared with controls who straightened to 101.6% ± 0.1% from 102.9% ± 0.3% in central gaze (P = 8.7 × 10-6); and globes retracted 0.73 ± 0.09 mm in POAG, but only 0.07 ± 0.08 mm in controls (P = 8.8 × 10-7). Both effects were confirmed in age-matched controls, and remained significant after correction for significant effects of age and axial globe length (P = 0.005).ConclusionsAlthough tethering and elongation of ON and sheath are normal in adduction, adduction is associated with abnormally great globe retraction in POAG without elevated IOP. Traction in adduction may cause mechanical overloading of the ON head and peripapillary sclera, thus contributing to or resulting from the optic neuropathy of glaucoma independent of IOP.
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- 2017
47. Association of Structural and Functional Measures With Contrast Sensitivity in Glaucoma.
- Author
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Fatehi, Nima, Nowroozizadeh, Sara, Henry, Sharon, Coleman, Anne L, Caprioli, Joseph, and Nouri-Mahdavi, Kouros
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Retinal Ganglion Cells ,Humans ,Glaucoma ,Disease Progression ,Tomography ,Optical Coherence ,Prospective Studies ,Cross-Sectional Studies ,Contrast Sensitivity ,Intraocular Pressure ,Visual Acuity ,Visual Fields ,Aged ,Female ,Male ,Visual Field Tests ,Neurodegenerative ,Eye Disease and Disorders of Vision ,Clinical Research ,Eye ,Clinical Sciences ,Opthalmology and Optometry ,Public Health and Health Services ,Ophthalmology & Optometry - Abstract
PurposeTo test the hypothesis that structural and functional measures predict contrast sensitivity (CS) outcomes in glaucomatous eyes.DesignCross-sectional prospective study.MethodsOne hundred five eyes of 65 patients who underwent macular spectral-domain optical coherence tomography imaging, 24-2 standard achromatic visual fields (VF), and CS measurement on the same day were enrolled. Association of CS at 4 spatial frequencies (3, 6, 12, and 18 cycles per degree, cpd) with structural and functional outcomes was explored with correlation and regression analyses.ResultsThe median (IQR) 24-2 visual field mean deviation was -7.6 (-11.1 to -3.0). Significant correlations were found between CS at 6 cpd and ganglion cell/inner plexiform layer thickness at inferotemporal and inferonasal macular sectors (ρ = 0.222, P = .023 and ρ = 0.209, P = .032, respectively). CS at 6 cpd demonstrated higher correlations with full macular thickness measurements, the strongest of which was with the central macular thickness in the superior 6 × 3-degree region (ρ = 0.311, P = .001). Contrast sensitivity at 6 cpd also had the strongest correlation with mean deviation of the 4 central VF points (ρ = -0.420; P < .001). There was a significant correlation between logMAR visual acuity and contrast sensitivity at 6, 12, and 18 cpd (ρ = -0.306, ρ = -0.348 and ρ = -0.241, P < .013, respectively).ConclusionsStructural and functional measures showed a fair relationship with contrast sensitivity. This association was most prominent between full-thickness macular measures or central VF parameters and CS at 6 cpd. Contrast sensitivity was not a reliable surrogate for glaucoma severity in this cross-sectional study.
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- 2017
48. Population-Based Frequency of Ophthalmic Adverse Events in Melanoma, Other Cancers, and After Immune Checkpoint Inhibitor Treatment
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Braun, David, Getahun, Darios, Chiu, Vicki Y., Coleman, Anne L., Holland, Gary N., Yu, Fei, Gordon, Lynn K., and Sun, Michel M.
- Published
- 2021
- Full Text
- View/download PDF
49. Strabismus After Ahmed Glaucoma Valve Implantation
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Robbins, Laura, Goseki, Toshiaki, Law, Simon K., Nouri-Mahdavi, Kouros, Caprioli, Joseph, Coleman, Anne L., Giaconi, Joann A., Demer, Joseph L., Velez, Federico G., and Pineles, Stacy L.
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- 2021
- Full Text
- View/download PDF
50. Prevalence of Ophthalmologic Diagnoses in Children With Autism Spectrum Disorder Using the Optum Dataset: APopulation-Based Study
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Chang, Melinda Y., Doppee, Danielle, Yu, Fei, Perez, Claudia, Coleman, Anne L., and Pineles, Stacy L.
- Published
- 2021
- Full Text
- View/download PDF
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