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2. Validation of the Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) questionnaire for adults

Author

Solmi, Marco, Thompson, Trevor, Estradé, Andrés, Agorastos, Agorastos, Radua, Joaquim, Cortese, Samuele, Dragioti, Elena, Leisch, Friedrich, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schlögelhofer, Monika, Aschauer, Elena, Schneeberger, Andres, Huber, Christian G, Hasler, Gregor, Conus, Philippe, Do Cuénod, Kim Q, von Känel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre-Michel, Krebs, Marie-Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Żydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kamiński, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan-Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Manková, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Saccon, Diego, Righi, Elena, Monaco, Francesco, Croatto, Giovanni, Cereda, Guido, Demurtas, Jacopo, Brondino, Natascia, Veronese, Nicola, Enrico, Paolo, Politi, Pierluigi, Ciappolino, Valentina, Pfennig, Andrea, Bechdolf, Andreas, Meyer-Lindenberg, Andreas, Kahl, Kai G, Domschke, Katharina, Bauer, Michael, Koutsouleris, Nikolaos, Winter, Sibylle, Borgwardt, Stefan, Bitter, Istvan, Balazs, Judit, Czobor, Pál, Unoka, Zsolt, Mavridis, Dimitris, Tsamakis, Konstantinos, Bozikas, Vasilios P, Tunvirachaisakul, Chavit, Maes, Michael, Rungnirundorn, Teerayuth, Supasitthumrong, Thitiporn, Haque, Ariful, Brunoni, Andre R, Costardi, Carlos Gustavo, Schuch, Felipe Barreto, Polanczyk, Guilherme, Luiz, Jhoanne Merlyn, Fonseca, Lais, Aparicio, Luana V, Valvassori, Samira S, Nordentoft, Merete, Vendsborg, Per, Hoffmann, Sofie Have, Sehli, Jihed, Sartorius, Norman, Heuss, Sabina, Guinart, Daniel, Hamilton, Jane, Kane, John, Rubio, Jose, and Sand, Michael

Subjects
Clinical and Health Psychology, Health Sciences, Psychology, Mental Health, Behavioral and Social Science, Brain Disorders, Depression, Mental health, Good Health and Well Being, Humans, Adult, Reproducibility of Results, Pandemics, COVID-19, Surveys and Questionnaires, Outcome Assessment, Health Care, Factor Analysis, Statistical, Psychometrics, Covid-19, Pandemic, COH-FIT, Survey: P-factor: well-being: mental health: psychiatry: psychometric, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundThe Collaborative Outcome study on Health and Functioning during Infection Times (COH-FIT; www.coh-fit.com) is an anonymous and global online survey measuring health and functioning during the COVID-19 pandemic. The aim of this study was to test concurrently the validity of COH-FIT items and the internal validity of the co-primary outcome, a composite psychopathology "P-score".MethodsThe COH-FIT survey has been translated into 30 languages (two blind forward-translations, consensus, one independent English back-translation, final harmonization). To measure mental health, 1-4 items ("COH-FIT items") were extracted from validated questionnaires (e.g. Patient Health Questionnaire 9). COH-FIT items measured anxiety, depressive, post-traumatic, obsessive-compulsive, bipolar and psychotic symptoms, as well as stress, sleep and concentration. COH-FIT Items which correlated r ≥ 0.5 with validated companion questionnaires, were initially retained. A P-score factor structure was then identified from these items using exploratory factor analysis (EFA) and confirmatory factor analyses (CFA) on data split into training and validation sets. Consistency of results across languages, gender and age was assessed.ResultsFrom >150,000 adult responses by May 6th, 2022, a subset of 22,456 completed both COH-FIT items and validated questionnaires. Concurrent validity was consistently demonstrated across different languages for COH-FIT items. CFA confirmed EFA results of five first-order factors (anxiety, depression, post-traumatic, psychotic, psychophysiologic symptoms) and revealed a single second-order factor P-score, with high internal reliability (ω = 0.95). Factor structure was consistent across age and sex.ConclusionsCOH-FIT is a valid instrument to globally measure mental health during infection times. The P-score is a valid measure of multidimensional mental health.

Published
2023

3. Collaborative outcomes study on health and functioning during infection times (COH-FIT): Insights on modifiable and non-modifiable risk and protective factors for wellbeing and mental health during the COVID-19 pandemic from multivariable and network analyses

Author

Solmi, Marco, Thompson, Trevor, Cortese, Samuele, Estradé, Andrés, Agorastos, Agorastos, Radua, Joaquim, Dragioti, Elena, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schlögelhofer, Monika, Aschauer, Elena, Schneeberger, Andres, Huber, Christian G., Hasler, Gregor, Conus, Philippe, Cuénod, Kim Q. Do, von Känel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre-Michel, Krebs, Marie-Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Żydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kamiński, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan-Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Manková, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Saccon, Diego, Righi, Elena, Monaco, Francesco, Croatto, Giovanni, Cereda, Guido, Demurtas, Jacopo, Brondino, Natascia, Veronese, Nicola, Enrico, Paolo, Politi, Pierluigi, Ciappolino, Valentina, Pfennig, Andrea, Bechdolf, Andreas, Meyer-Lindenberg, Andreas, Kahl, Kai G., Domschke, Katharina, Bauer, Michael, Koutsouleris, Nikolaos, Winter, Sibylle, Borgwardt, Stefan, Bitter, Istvan, Balazs, Judit, Czobor, Pál, Unoka, Zsolt, Mavridis, Dimitris, Tsamakis, Konstantinos, Bozikas, Vasilios P., Tunvirachaisakul, Chavit, Maes, Michael, Rungnirundorn, Teerayuth, Supasitthumrong, Thitiporn, Haque, Ariful, Brunoni, Andre R., Costardi, Carlos Gustavo, Schuch, Felipe Barreto, Polanczyk, Guilherme, Luiz, Jhoanne Merlyn, Fonseca, Lais, Aparicio, Luana V., Valvassori, Samira S., Nordentoft, Merete, Vendsborg, Per, Hoffmann, Sofie Have, Sehli, Jihed, Sartorius, Norman, Heuss, Sabina, Guinart, Daniel, Hamilton, Jane, Kane, John, Rubio, Jose, Sand, Michael, Koyanagi, Ai, Solanes, Aleix, Andreu-Bernabeu, Alvaro, Cáceres, Antonia San José, Arango, Celso, Díaz-Caneja, Covadonga M., Hidalgo-Mazzei, Diego, Vieta, Eduard, Gonzalez-Peñas, Javier, Fortea, Lydia, Parellada, Mara, Fullana, Miquel A., Verdolini, Norma, Andrlíková, Eva, Janků, Karolina, Millan, Mark J., Honciuc, Mihaela, Moniuszko-Malinowska, Anna, Łoniewski, Igor, Samochowiec, Jerzy, Kiszkiel, Łukasz, Marlicz, Maria, Sowa, Paweł, Marlicz, Wojciech, Spies, Georgina, Stubbs, Brendon, Firth, Joseph, Sullivan, Sarah, Darcin, Asli Enez, Aksu, Hatice, Dilbaz, Nesrin, Noyan, Onur, Kitazawa, Momoko, Kurokawa, Shunya, Tazawa, Yuki, Anselmi, Alejandro, Cracco, Cecilia, Machado, Ana Inés, Estrade, Natalia, De Leo, Diego, Curtis, Jackie, Berk, Michael, Carvalho, Andre F., Ward, Philip, Teasdale, Scott, Rosenbaum, Simon, Marx, Wolfgang, Horodnic, Adrian Vasile, Oprea, Liviu, Alexinschi, Ovidiu, Ifteni, Petru, Turliuc, Serban, Ciuhodaru, Tudor, Bolos, Alexandra, Matei, Valentin, Nieman, Dorien H., Sommer, Iris, van Os, Jim, van Amelsvoort, Therese, Sun, Ching-Fang, Guu, Ta-wei, Jiao, Can, Zhang, Jieting, Fan, Jialin, Zou, Liye, Yu, Xin, Chi, Xinli, de Timary, Philippe, van Winkel, Ruud, Ng, Bernardo, Peña de León, Edilberto, Arellano, Ramon, Roman, Raquel, Sanchez, Thelma, Movina, Larisa, Morgado, Pedro, Brissos, Sofia, Aizberg, Oleg, Mosina, Anna, Krinitski, Damir, Mugisha, James, Sadeghi-Bahmani, Dena, Sheybani, Farshad, Sadeghi, Masoud, Hadi, Samira, Brand, Serge, Errazuriz, Antonia, Crossley, Nicolas, Ristic, Dragana Ignjatovic, López-Jaramillo, Carlos, Efthymiou, Dimitris, Kuttichira, Praveenlal, Kallivayalil, Roy Abraham, Javed, Afzal, Afridi, Muhammad Iqbal, James, Bawo, Seb-Akahomen, Omonefe Joy, Fiedorowicz, Jess, Daskalakis, Jeff, Yatham, Lakshmi N., Yang, Lin, Okasha, Tarek, Dahdouh, Aïcha, Tiihonen, Jari, Shin, Jae Il, Lee, Jinhee, Mhalla, Ahmed, Gaha, Lotfi, Brahim, Takoua, Altynbekov, Kuanysh, Negay, Nikolay, Nurmagambetova, Saltanat, Jamei, Yasser Abu, Weiser, Mark, and Correll, Christoph U

Published
2025
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5. Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: Results from the international COH-FIT Study

Author

Solmi, Marco, Thompson, Trevor, Estradé, Andrés, Agorastos, Agorastos, Radua, Joaquim, Cortese, Samuele, Dragioti, Elena, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schlögelhofer, Monika, Aschauer, Elena, Schneeberger, Andres, Huber, Christian G., Hasler, Gregor, Conus, Philippe, Cuénod, Kim Q. Do, von Känel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre-Michel, Krebs, Marie-Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Żydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kamiński, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan-Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Manková, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Saccon, Diego, Righi, Elena, Monaco, Francesco, Croatto, Giovanni, Cereda, Guido, Demurtas, Jacopo, Brondino, Natascia, Veronese, Nicola, Enrico, Paolo, Politi, Pierluigi, Ciappolino, Valentina, Pfennig, Andrea, Bechdolf, Andreas, Meyer-Lindenberg, Andreas, Kahl, Kai G., Domschke, Katharina, Bauer, Michael, Koutsouleris, Nikolaos, Winter, Sibylle, Borgwardt, Stefan, Bitter, Istvan, Balazs, Judit, Czobor, Pál, Unoka, Zsolt, Mavridis, Dimitris, Tsamakis, Konstantinos, Bozikas, Vasilios P., Tunvirachaisakul, Chavit, Maes, Michael, Rungnirundorn, Teerayuth, Supasitthumrong, Thitiporn, Haque, Ariful, Brunoni, Andre R., Costardi, Carlos Gustavo, Schuch, Felipe Barreto, Polanczyk, Guilherme, Luiz, Jhoanne Merlyn, Fonseca, Lais, Aparicio, Luana V., Valvassori, Samira S., Nordentoft, Merete, Vendsborg, Per, Hoffmann, Sofie Have, Sehli, Jihed, Sartorius, Norman, Heuss, Sabina, Guinart, Daniel, Hamilton, Jane, Kane, John, Rubio, Jose, Sand, Michael, Koyanagi, Ai, Solanes, Aleix, Andreu-Bernabeu, Alvaro, Cáceres, Antonia San José, Arango, Celso, Díaz-Caneja, Covadonga M., Hidalgo-Mazzei, Diego, Vieta, Eduard, Gonzalez-Peñas, Javier, Fortea, Lydia, Parellada, Mara, Fullana, Miquel A., Verdolini, Norma, Andrlíková, Eva, Janků, Karolina, Millan, Mark J., Honciuc, Mihaela, Moniuszko-Malinowska, Anna, Łoniewski, Igor, Samochowiec, Jerzy, Kiszkiel, Łukasz, Marlicz, Maria, Sowa, Paweł, Marlicz, Wojciech, Spies, Georgina, Stubbs, Brendon, Firth, Joseph, Sullivan, Sarah, Darcin, Asli Enez, Aksu, Hatice, Dilbaz, Nesrin, Noyan, Onur, Kitazawa, Momoko, Kurokawa, Shunya, Tazawa, Yuki, Anselmi, Alejandro, Cracco, Cecilia, Machado, Ana Inés, Estrade, Natalia, De Leo, Diego, Curtis, Jackie, Berk, Michael, Carvalho, Andre F., Ward, Philip, Teasdale, Scott, Rosenbaum, Simon, Marx, Wolfgang, Horodnic, Adrian Vasile, Oprea, Liviu, Alexinschi, Ovidiu, Ifteni, Petru, Turliuc, Serban, Ciuhodaru, Tudor, Bolos, Alexandra, Matei, Valentin, Nieman, Dorien H., Sommer, Iris, van Os, Jim, van Amelsvoort, Therese, Sun, Ching-Fang, Guu, Ta-wei, Jiao, Can, Zhang, Jieting, Fan, Jialin, Zou, Liye, Yu, Xin, Chi, Xinli, de Timary, Philippe, van Winkel, Ruud, Ng, Bernardo, Peña de León, Edilberto, Arellano, Ramon, Roman, Raquel, Sanchez, Thelma, Movina, Larisa, Morgado, Pedro, Brissos, Sofia, Aizberg, Oleg, Mosina, Anna, Krinitski, Damir, Mugisha, James, Sadeghi-Bahmani, Dena, Sheybani, Farshad, Sadeghi, Masoud, Hadi, Samira, Brand, Serge, Errazuriz, Antonia, Crossley, Nicolas, Ristic, Dragana Ignjatovic, López-Jaramillo, Carlos, Efthymiou, Dimitris, Kuttichira, Praveenlal, Kallivayalil, Roy Abraham, Javed, Afzal, Afridi, Muhammad Iqbal, James, Bawo, Seb-Akahomen, Omonefe Joy, Fiedorowicz, Jess, Daskalakis, Jeff, Yatham, Lakshmi N., Yang, Lin, Okasha, Tarek, Dahdouh, Aïcha, Tiihonen, Jari, Shin, Jae Il, Lee, Jinhee, Mhalla, Ahmed, Gaha, Lotfi, Brahim, Takoua, Altynbekov, Kuanysh, Negay, Nikolay, Nurmagambetova, Saltanat, Jamei, Yasser Abu, Weiser, Mark, and Correll, Christoph U.

Published
2024
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6. Collaborative Outcomes Study on Health and Functioning During Infection Times (COH-FIT): Global and Risk-Group Stratified Course of Well-Being and Mental Health During the COVID-19 Pandemic in Adolescents

Author

Solmi, Marco, Thompson, Trevor, Cortese, Samuele, Estradé, Andrés, Agorastos, Agorastos, Radua, Joaquim, Dragioti, Elena, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schlögelhofer, Monika, Aschauer, Elena, Schneeberger, Andres Andres, Huber, Christian G., Hasler, Gregor, Conus, Philippe, Do Cuénod, Kim Q., von Känel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre-Michel, Krebs, Marie-Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Żydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kamiński, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan-Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Manková, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Saccon, Diego, Righi, Elena, Monaco, Francesco, Croatto, Giovanni, Cereda, Guido, Demurtas, Jacopo, Brondino, Natascia, Veronese, Nicola, Enrico, Paolo, Politi, Pierluigi, Ciappolino, Valentina, Pfennig, Andrea, Bechdolf, Andreas, Meyer-Lindenberg, Andreas, Kahl, Kai G., Domschke, Katharina, Bauer, Michael, Koutsouleris, Nikolaos, Winter, Sibylle, Borgwardt, Stefan, Bitter, Istvan, Balazs, Judit, Czobor, Pál, Unoka, Zsolt, Mavridis, Dimitris, Tsamakis, Konstantinos, Bozikas, Vasilios P., Tunvirachaisakul, Chavit, Maes, Michael, Rungnirundorn, Teerayuth, Supasitthumrong, Thitiporn, Haque, Ariful, Brunoni, Andre R., Costardi, Carlos Gustavo, Schuch, Felipe Barreto, Polanczyk, Guilherme, Luiz, Jhoanne Merlyn, Fonseca, Lais, Aparicio, Luana V., Valvassori, Samira S., Nordentoft, Merete, Vendsborg, Per, Hoffmann, Sofie Have, Sehli, Jihed, Sartorius, Norman, Heuss, Sabina, Guinart, Daniel, Hamilton, Jane, Kane, John, Rubio, Jose, Sand, Michael, Koyanagi, Ai, Solanes, Aleix, Andreu-Bernabeu, Alvaro, San José Cáceres, Antonia, Arango, Celso, Díaz-Caneja, Covadonga M., Hidalgo-Mazzei, Diego, Vieta, Eduard, Gonzalez-Peñas, Javier, Fortea, Lydia, Parellada, Mara, Fullana, Miquel A., Verdolini, Norma, Andrlíková, Eva, Janků, Karolina, Millan, Mark J., Honciuc, Mihaela, Moniuszko-Malinowska, Anna, Łoniewski, Igor, Samochowiec, Jerzy, Kiszkiel, Łukasz, Marlicz, Maria, Sowa, Paweł, Marlicz, Wojciech, Spies, Georgina, Stubbs, Brendon, Firth, Joseph, Sullivan, Sarah, Darcin, Asli Enez, Aksu, Hatice, Dilbaz, Nesrin, Noyan, Onur, Kitazawa, Momoko, Kurokawa, Shunya, Tazawa, Yuki, Anselmi, Alejandro, Cracco, Cecilia, Machado, Ana Inés, Estrade, Natalia, De Leo, Diego, Curtis, Jackie, Berk, Michael, Carvalho, Andre F., Ward, Philip, Teasdale, Scott, Rosenbaum, Simon, Marx, Wolfgang, Horodnic, Adrian Vasile, Oprea, Liviu, Alexinschi, Ovidiu, Ifteni, Petru, Turliuc, Serban, Ciuhodaru, Tudor, Bolos, Alexandra, Matei, Valentin, Nieman, Dorien H., Sommer, Iris, van Os, Jim, van Amelsvoort, Therese, Sun, Ching-Fang, Guu, Ta-wei, Jiao, Can, Zhang, Jieting, Fan, Jialin, Zou, Liye, Yu, Xin, Chi, Xinli, de Timary, Philippe, van Winkel, Ruud, Ng, Bernardo, Pena, Edilberto, Arellano, Ramon, Roman, Raquel, Sanchez, Thelma, Movina, Larisa, Morgado, Pedro, Brissos, Sofia, Aizberg, Oleg, Mosina, Anna, Krinitski, Damir, Mugisha, James, Sadeghi-Bahmani, Dena, Sheybani, Farshad, Sadeghi, Masoud, Hadi, Samira, Brand, Serge, Errazuriz, Antonia, Crossley, Nicolas, Ristic, Dragana Ignjatovic, López-Jaramillo, Carlos, Efthymiou, Dimitris, Kuttichira, Praveenlal, Kallivayalil, Roy Abraham, Javed, Afzal, Afridi, Muhammad Iqbal, James, Bawo, Seb-Akahomen, Omonefe Joy, Fiedorowicz, Jess, Daskalakis, Jeff, Yatham, Lakshmi N., Yang, Lin, Okasha, Tarek, Dahdouh, Aïcha, Tiihonen, Jari, Shin, Jae Il, Lee, Jinhee, Mhalla, Ahmed, Gaha, Lotfi, Brahim, Takoua, Altynbekov, Kuanysh, Negay, Nikolay, Nurmagambetova, Saltanat, Jamei, Yasser Abu, Weiser, Mark, and Correll, Christoph U.

Published
2025
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12. Prenatal insomnia disorder may predict concurrent and postpartum psychopathology: A longitudinal study.

Author

Palagini, Laura, Miniati, Mario, Driul, Lorenza, Colizzi, Marco, Comacchio, Carla, Gemignani, Angelo, and Balestrieri, Matteo

Subjects
EDINBURGH Postnatal Depression Scale, PSYCHOSOCIAL functioning, SOCIAL adjustment, ODDS ratio, PATHOLOGICAL psychology
Abstract

Summary: While insomnia symptoms may be a risk factor for mental disturbances, few studies evaluated "Insomnia Disorder" and its relationship with perinatal psychopathology. Pregnant women were recruited during their last routine assessment before being hospitalized for delivery during the 3rd trimester at the Gynaecological Unit of the University Hospital of Ferrara and Udine, Italy, from January 2022 to January 2023. Our assessment included baseline evaluation (T0), and evaluations at 1 month (T1) and 3 months (T2) in the postpartum period, with specific questionnaires for insomnia disorder, such as Sleep Condition Indicator, mood and anxiety symptoms and psychosocial functioning, such as Edinburgh Postnatal Depression Scale, Mood Disorder Questionnaire, State–Trait Anxiety Inventory, Work and Social Adjustment Scale. At T0, 181 pregnant women were included. Insomnia disorder affected 22.3% at T0, 23.5% at T1 and 16.2% at T2. Women with insomnia disorder at baseline were significantly more affected by concurrent anxiety and depressive symptoms, had higher bipolar diathesis and poorer psychosocial functioning in the perinatal period. Prenatal insomnia disorder predicted anxiety (T0: odds ratio 4.44, p << 0.001; T1: odds ratio 4.009, p = 0.042) and depressive symptoms (T0: odds ratio 2.66, p = 0.015; T1: odds ratio 11.20, p = 0.001; T2: odds ratio 12.50 p = 0.049) in both the prenatal and postnatal period. It also predicted poor psychosocial function during the prenatal (odds ratio 3.55, p = 0.003) and postpartum periods (T1: odds ratio 2.33, p = 0.004). Insomnia disorder is emerging as an important prenatal factor that may contribute to concurrent and postpartum psychopathology. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Is a No-Restraint Policy Associated with Increased Aggression Towards Healthcare Professionals Among Inpatient Psychiatric Units? A 16-Year Retrospective Observational Study Conducted in Italy.

Author

Colizzi, Marco, Comacchio, Carla, Garzitto, Marco, Napoli, Giovanni, Battiston, Chiara, Tam, Tatiana, Bertoli, Marco, Anzallo, Calogero, Palese, Alvisa, and Balestrieri, Matteo

Subjects
PSYCHOTHERAPY patients, ACADEMIC medical centers, T-test (Statistics), VIOLENCE against medical personnel, SCIENTIFIC observation, KRUSKAL-Wallis Test, RESTRAINT of patients, RETROSPECTIVE studies, MANN Whitney U Test, AGGRESSION (Psychology), WORK-related injuries, PATIENT-professional relations, STATISTICS, PSYCHIATRIC hospitals, DATA analysis software, PSYCHOSOCIAL factors, SHIFT systems
Abstract

The aim of this study was to investigate aggression-related work accidents in an inpatient psychiatric unit before and after implementing a no-restraint policy in Italy. Results revealed that, over the study period (2007–2022), 113 accidents occurred, mostly related to physical aggression (81.4%), with healthcare assistants and psychiatric nurses being the most affected and more accidents occurring during the morning shift (49.6%). A transitory peak of accidents occurred during the policy transition (χ22 = 16.0, p < 0.001; V = 1.000), falling rapidly in the subsequent years. In conclusion, adopting a no-restraint policy is not associated with increased aggression toward staff in psychiatric healthcare in the longer term, although greater support is needed during the transition phase to minimize risks. [ABSTRACT FROM AUTHOR]

Published
2024
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15. The Endocannabinoid Activity Remodulation for Psychosis Liability in Youth (EARLY) Study: An Open-Label Feasibility Trial of Ultramicronized-Palmitoylethanolamide Oral Supplementation in Clinical High-Risk State for Psychosis.

Author

Bortoletto, Riccardo, Garzitto, Marco, Piscitelli, Fabiana, Fornasaro, Stefano, Scipioni, Claudia, Sepulcri, Orietta, Fabris, Martina, Curcio, Francesco, Balestrieri, Matteo, and Colizzi, Marco

Subjects
YOUNG adults, DIETARY supplements, PSYCHOSES, MODULATION (Music theory), PSYCHIATRIC drugs
Abstract

To date, no psychotropic medication has shown to effectively halt progression to psychosis among individuals at Clinical High-Risk for psychosis (CHR), fueling the search for novel therapeutic agents. Recent evidence supports Palmitoylethanolamide (PEA) signaling as a potential psychosis biomarker, also indicating a therapeutic role for its supplementation in the treatment of psychotic disorders. Nonetheless, the effect of sustained PEA intake in CHR subjects has never been explored so far. We will assess the feasibility of enrolling 20 CHR young adults presenting with attenuated psychotic symptoms (APS) in a 12-week, open-label, investigator-initiated, proof-of-concept, single-arm trial of ultramicronized-PEA (um-PEA) 600 mg/day. Once completed the 12-week phase, participants will be proposed to enter a 24-week extension phase of the study. We will examine um-PEA ability to reduce APS and psychic distress, um-PEA safety and tolerability, and the biological basis of um-PEA effect in terms of modulation of inflammatory response, endocannabinoid (eCB) signaling, and microbiome composition. Our trial aims to address an unmet clinical need in CHR subjects, providing an initial solid basis for the development of future studies evaluating the efficacy and tolerability of PEA supplementation in this group of patients. [ABSTRACT FROM AUTHOR]

Published
2024
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16. The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic

Author

Solmi, Marco, Estradé, Andrés, Thompson, Trevor, Agorastos, Agorastos, Radua, Joaquim, Cortese, Samuele, Dragioti, Elena, Leisch, Friedrich, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schloegelhofer, Monika, Akimova, Elena, Schneeberger, Andres, Huber, Christian G., Hasler, Gregor, Conus, Philippe, Cuénod, Kim Q. Do, von Känel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre-Michel, Krebs, Marie-Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Żydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kamiński, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan-Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Manková, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Saccon, Diego, Righi, Elena, Monaco, Francesco, Croatto, Giovanni, Cereda, Guido, Demurtas, Jacopo, Brondino, Natascia, Veronese, Nicola, Enrico, Paolo, Politi, Pierluigi, Ciappolino, Valentina, Pfennig, Andrea, Bechdolf, Andreas, Meyer-Lindenberg, Andreas, Kahl, Kai G., Domschke, Katharina, Bauer, Michael, Koutsouleris, Nikolaos, Winter, Sibylle, Borgwardt, Stefan, Bitter, Istvan, Balazs, Judit, Czobor, Pal, Unoka, Zsolt, Mavridis, Dimitris, Tsamakis, Konstantinos, Bozikas, Vasilios P., Tunvirachaisakul, Chavit, Maes, Michael, Rungnirundorn, Teerayuth, Supasitthumrong, Thitiporn, Haque, Ariful, Brunoni, Andre R., Costardi, Carlos Gustavo, Schuch, Felipe Barreto, Polanczyk, Guilherme, Luiz, Jhoanne Merlyn, Fonseca, Lais, Aparicio, Luana V., Valvassori, Samira S., Nordentoft, Merete, Vendsborg, Per, Hoffmann, Sofie Have, Sehli, Jihed, Sartorius, Norman, Heuss, Sabina, Guinart, Daniel, Hamilton, Jane, Kane, John, Rubio, Jose, Sand, Michael, Koyanagi, Ai, Solanes, Aleix, Andreu-Bernabeu, Alvaro, Cáceres, Antonia San José, Arango, Celso, Díaz-Caneja, Covadonga M., Hidalgo-Mazzei, Diego, Vieta, Eduard, Gonzalez-Peñas, Javier, Fortea, Lydia, Parellada, Mara, Fullana, Miquel A., Verdolini, Norma, Fárková, Eva, Janků, Karolina, Millan, Mark, Honciuc, Mihaela, Moniuszko-Malinowska, Anna, Łoniewski, Igor, Samochowiec, Jerzy, Kiszkiel, Łukasz, Marlicz, Maria, Sowa, Paweł, Marlicz, Wojciech, Spies, Georgina, Stubbs, Brendon, Firth, Joseph, Sullivan, Sarah, Darcin, Asli Enez, Aksu, Hatice, Dilbaz, Nesrin, Noyan, Onur, Kitazawa, Momoko, Kurokawa, Shunya, Tazawa, Yuki, Anselmi, Alejandro, Cracco, Cecilia, Machado, Ana Inés, Estrade, Natalia, De Leo, Diego, Curtis, Jackie, Berk, Michael, Ward, Philip, Teasdale, Scott, Rosenbaum, Simon, Marx, Wolfgang, Horodnic, Adrian Vasile, Oprea, Liviu, Alexinschi, Ovidiu, Ifteni, Petru, Turliuc, Serban, Ciuhodaru, Tudor, Bolos, Alexandra, Matei, Valentin, Nieman, Dorien H., Sommer, Iris, van Os, Jim, van Amelsvoort, Therese, Sun, Ching-Fang, Guu, Ta-wei, Jiao, Can, Zhang, Jieting, Fan, Jialin, Zou, Liye, Yu, Xin, Chi, Xinli, de Timary, Philippe, van Winke, Ruud, Ng, Bernardo, Pena, Edilberto, Arellano, Ramon, Roman, Raquel, Sanchez, Thelma, Movina, Larisa, Morgado, Pedro, Brissos, Sofia, Aizberg, Oleg, Mosina, Anna, Krinitski, Damir, Mugisha, James, Sadeghi-Bahmani, Dena, Sadeghi, Masoud, Hadi, Samira, Brand, Serge, Errazuriz, Antonia, Crossley, Nicolas, Ristic, Dragana Ignjatovic, López-Jaramillo, Carlos, Efthymiou, Dimitris, Kuttichira, Praveenlal, Kallivayalil, Roy Abraham, Javed, Afzal, Afridi, Muhammad Iqbal, James, Bawo, Seb-Akahomen, Omonefe Joy, Fiedorowicz, Jess, Carvalho, Andre F., Daskalakis, Jeff, Yatham, Lakshmi N., Yang, Lin, Okasha, Tarek, Dahdouh, Aïcha, Gerdle, Björn, Tiihonen, Jari, Shin, Jae Il, Lee, Jinhee, Mhalla, Ahmed, Gaha, Lotfi, Brahim, Takoua, Altynbekov, Kuanysh, Negay, Nikolay, Nurmagambetova, Saltanat, Jamei, Yasser Abu, Weiser, Mark, and Correll, Christoph U.

Published
2022
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17. Imaging the neurocognitive and neurochemical effects of cannabinoids on the human brain

Author

Colizzi, Marco, Bhattacharyya, Sagnik, and McGuire, Philip

Subjects
615.7
Abstract

There is longstanding evidence that cannabis use represents an environmental risk factor for psychosis and may impair cognitive functioning. The detrimental effects of cannabis use appear to be mainly driven by its key psychoactive ingredient delta-9-tetrahydrocannabinol (Δ9-THC). Also, individuals may respond differently to Δ9-THC as a function of their previous exposure to cannabis, possibly due to the development of tolerance. The use of Δ9-THC as a drug model for psychosis is well documented in the literature and experimental investigations employing Δ9-THC challenge have proven to be effective in investigating the neural underpinnings of emerging psychotomimetic and anxiety symptoms. In this thesis I aimed to contribute to a better understanding of the neurobiological mechanisms underlying the association between cannabis use and psychosis, by employing pharmacological magnetic resonance imaging (phMRI) with oral or intravenous Δ9-THC challenge to assess changes in neurophysiology (functional MRI, fMRI) and neurochemistry (proton magnetic resonance spectroscopy, 1H-MRS). Two independent samples of healthy individuals differing in the extent of their previous cannabis exposure and abstinent from cannabis for at least 3 months underwent 2 testing sessions with at least 2-week inter-scan interval employing a double-blind, placebo-controlled, within-subjects design. In the first study sample (N=36), I investigated the effects of previous cannabis exposure, acute Δ9-THC administration, and their interaction on brain activity and related behavior while performing different cognitive tasks, including verbal memory, response inhibition, attentional salience, and emotional processing. In the second study sample (N=16), I investigated the effect of acute Δ9-THC administration on psychotomimetic symptom manifestation as well as glutamate levels in the striatum, hippocampus, and anterior cingulate, and their association. Acute administration of Δ9-THC induced anxiety and psychotomimetic symptoms, the latter being more pronounced in individuals who had never used cannabis. Similarly, Δ9-THC challenge induced neurophysiological dysfunction and associated poorer cognitive functioning that were more marked in non-users. Indeed, among the non-users those experiencing the most severe psychotomimetic symptoms and cognitive impairments had the greatest neurophysiological dysfunction under the effect of Δ9-THC. Also, Δ9-THC challenge appeared to transiently reverse some of the neurocognitive impairments observed in cannabis users. Results from this thesis support an effect of acute Δ9-THC administration on glutamate signaling, specifically an increase in the total glutamatergic pool available for synaptic/ metabolic activity in the form of glutamate or glutamine in the striatum. As exploratory analyses revealed no effect of Δ9-THC on glutamate signaling neither in the anterior cingulate nor in the hippocampus, this disruptive effect of Δ9-THC on striatal glutamate levels appeared to be region-specific. Also, the Δ9-THC-induced increase in striatal glutamate seemed to modulate the manifestation of psychotomimetic symptoms, such that the Δ9-THC-induced Glutamate + Glutamine increase was more marked in those experiencing psychotomimetic symptoms following the acute challenge. Moreover, those exposed to cannabis the most often had the highest increase in glutamate-derived metabolites under the effect of Δ9-THC. These findings suggest that cannabis use may induce psychosis-like symptoms by disrupting glutamate signaling in the striatum. Also, they indicate that cannabis use may affect brain function in order to induce acute neurocognitive effects. Further studies are needed to track longitudinally the long-term changes in striatal glutamate and brain function in the context of cannabis use as pathophysiological mechanisms that may underlie the development of psychosis and cognitive impairments.

Published
2018

18. Assessing the biobehavioral effects of ultramicronized-palmitoylethanolamide monotherapy in autistic adults with different severity levels: a report of two cases.

Author

Bortoletto, Riccardo, Piscitelli, Fabiana, Basaldella, Marta, Scipioni, Claudia, Comacchio, Carla, Fiorino, Roberta, Fornasaro, Stefano, Barbieri, Pierluigi, Pagliaro, Daniele, Sepulcri, Orietta, Fabris, Martina, Curcio, Francesco, Balestrieri, Matteo, and Colizzi, Marco

Subjects
PSYCHOSOCIAL functioning, AUTISM spectrum disorders, PSYCHOLOGICAL distress, MENTAL depression, TREATMENT effectiveness
Abstract

Despite promise of its supplementation as both monotherapy and add-on treatment in autism spectrum disorder (ASD), the biobehavioral effects of Palmitoylethanolamide (PEA) in autistic adults have never been explored so far. We discussed the cases of two autistic adults with different degrees of severity (level 1 and level 2) presenting with symptoms of psychic distress, who were treated with ultramicronized-PEA (um-PEA) 600 mg/day monotherapy for a sustained period of 4 months. The level 1 autistic patient showed improved depressive symptoms and social engagement at a 12-week follow-up, in parallel to a tendency toward reduced inflammatory response and enhanced endocannabinoid (eCB) signaling, partially relapsing after um-PEA discontinuation at four months. Opposedly, the level 2 autistic patient exhibited a generally stable psychosocial functioning for the initial 12 weeks, consistent with basically unchanged immune and eCBs levels, abruptly deteriorating and leading to antipsychotic initiation afterwards. No significant side effects were reported in both cases during the observation period. The two cases suggest that um-PEA could be an effective option for the treatment of psychic distress in level 1 autistic adults, warranting further investigation of its age- and level-specificity and of the biological underpinnings of its therapeutic effect in ASD. [ABSTRACT FROM AUTHOR]

Published
2024
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22. The Endocannabinoid Activity Remodulation for psychosis Liability in Youth (EARLY) Study: An Open-Label Feasibility Trial of Palmitoylethanolamide Oral Supplementation in Clinical High-Risk State for Psychosis

Author

Bortoletto, Riccardo, primary, Garzitto, Marco, additional, Piscitelli, Fabiana, additional, Comacchio, Carla, additional, Curcio, Francesco, additional, Fabris, Martina, additional, Sepulcri, Orietta, additional, Balestrieri, Matteo, additional, and Colizzi, Marco, additional

Published
2024
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24. The 2019 Schizophrenia International Research Society Conference, 10–14 April, Orlando, Florida: A summary of topics and trends

Author

Alameda, Luis, Ashok, Abhishekh, Avery, Suzanne, Bani-Fatemi, Ali, Berkhout, Susan, Best, Mike, Bonfils, Kelsey, Colizzi, Marco, Dauvermann, Maria, Plessis, Stefan Du, Dwyer, Dominic, Eisner, Emily, Ganesh, Suhas, Hernaus, Dennis, Ithal, Dhruva, Kowalchuk, Chantel, Kristensen, Tina, Lavigne, Katie, Lee, Ellen, Lemmers-Jansen, Imke, O'Donoghue, Brian, Oliver, Lindsay, Oluwoye, Oladunni, Park, Min Tae, Di Carlo, Pasquale, Joaquim, Helena Passarelli Giroud, Pinheiro, Ana, Ramsay, Ian, Rodriguez, Victoria, Sami, Musa, Soni, Sunaina, Sonnenschein, Susan, Taylor, Jerome, Thomas, Michael, Waterreus, Anna, Wojtalik, Jessica, Yang, Zhuoya, Emsley, Robin, and Kilian, Sanja

Published
2020
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25. Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: Results from the international COH-FIT Study

Author

Hersenen-Medisch 1, Brain, Solmi, Marco, Thompson, Trevor, Estradé, Andrés, Agorastos, Agorastos, Radua, Joaquim, Cortese, Samuele, Dragioti, Elena, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schlögelhofer, Monika, Aschauer, Elena, Schneeberger, Andres, Huber, Christian G., Hasler, Gregor, Conus, Philippe, Cuénod, Kim Q.Do, von Känel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre Michel, Krebs, Marie Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Żydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kamiński, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Manková, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Sommer, Iris, van Os, Jim, Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands (GJB, GJER), Hersenen-Medisch 1, Brain, Solmi, Marco, Thompson, Trevor, Estradé, Andrés, Agorastos, Agorastos, Radua, Joaquim, Cortese, Samuele, Dragioti, Elena, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schlögelhofer, Monika, Aschauer, Elena, Schneeberger, Andres, Huber, Christian G., Hasler, Gregor, Conus, Philippe, Cuénod, Kim Q.Do, von Känel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre Michel, Krebs, Marie Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Żydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kamiński, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Manková, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Sommer, Iris, van Os, Jim, and Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands (GJB, GJER)

Published
2024

30. Lessons Learnt From Running a Transition‐Age Youth Mental Health Outpatient Clinic in Italy: The PRecocity of Intervention in Adolescent Medicine (PRIMA) Experience.

Author

Colizzi, Marco, Basaldella, Marta, Candolo, Anna, Garzitto, Marco, Palermo, Andrea, Scipioni, Claudia, Tavian, Giovanna, Balestrieri, Matteo, Bortoletto, Riccardo, and Comacchio, Carla

Subjects
*MENTAL health services, *YOUNG adults, *HEALTH facilities, *ATTENTION-deficit hyperactivity disorder, *AUTISM spectrum disorders
Abstract

ABSTRACT Aim Methods Results and Discussion Conclusion This study assessed whether transition age between adolescence and young adulthood poses a challenge for both patients and mental health services.We retrospectively examined the baseline characteristics, diagnoses and treatments of 99 individuals aged 16–35 presenting to the PRecocity of Intervention in Adolescent Medicine (PRIMA) transition‐age mental health outpatient clinic, Italy, over a 24‐month period.Most patients were female, aged 20 or younger, employed and did not experience impairment in daily autonomies. About half patients were referred by general practitioners or self‐referred, often as initial contact with any adult mental health services, complaining with multiple symptoms (88%), mainly including anxiety, affective disturbances and insomnia. Most of them received a single diagnosis (68%), one out of three being diagnosed with a neurodevelopmental disorder. Patients presenting with anxiety (63% vs. 32%; OR = 3.55, p = 0.01) and affective symptoms (56% vs .23%; OR = 4.26, p = 0.01) and receiving multiple diagnoses (30% vs. 9%; χ2(2) = 19.7, p < 0.01) were more likely to be prescribed with psychopharmacological medication at the first visit. At a 6‐month follow‐up, one in two patients remained in PRIMA, while the others required different services tailored to their specific conditions, especially neurodevelopmental disorders.Findings from this study warrant the need for specialised mental healthcare facilities ensuring timely and high‐quality interventions for adolescents transitioning into young adulthood. [ABSTRACT FROM AUTHOR]

Published
2024
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31. The Supplementation Therapy in Autism and Response to Treatment (START) Study: An Open-Label Feasibility Trial of Ultramicronized Palmitoylethanolamide Potential to Alleviate Psychic Distress among Autistic Adults.

Author

Bortoletto, Riccardo, Basaldella, Marta, Candolo, Anna, Garzitto, Marco, Comacchio, Carla, Curcio, Francesco, Fabris, Martina, Fornasaro, Stefano, Piscitelli, Fabiana, Sepulcri, Orietta, Balestrieri, Matteo, and Colizzi, Marco

Subjects
AUTISM spectrum disorders, AMIDES, PSYCHOLOGICAL distress, COMMUNICATIVE disorders, MEDICATION safety
Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by impaired social communication and restricted or repetitive behavior and interests. Psychic distress is common among individuals with ASD, especially in its milder form (level 1), with anxiety and depression being the most common types. Recent research has identified neuroinflammation and gut dysbiosis as potential neurobiological mechanisms underlying ASD. Palmitoylethanolamide (PEA), an endocannabinoid (eCB)-like compound, has shown promise in modulating such mechanisms and may thus have therapeutic implications for ASD. To date, no clinical trial has evaluated the efficacy of PEA in adults with ASD. This 12-week open-label study will assess the feasibility, tolerability, safety, and efficacy of ultramicronized PEA (um-PEA) in treating symptoms of psychic distress, such as anxiety and depression, in adults with level 1 ASD. Secondary research endpoints will include um-PEA's effects on levels of personal autonomy and neurocognitive and interpersonal function. From a biological point of view, this study will assess um-PEA's effects on inflammatory markers, the metabolic profile, eCB system modulation, and microbial composition as potential mechanisms of action for its therapeutic effect. In conclusion, this study will investigate a novel approach to the treatment of adults presenting with psychic distress in the context of level 1 ASD. The results may provide valuable insight into the use of um-PEA as a treatment option for ASD adults, addressing a significant unmet clinical need. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Risk of psychosis in autism spectrum disorder individuals exposed to psychosocial stressors: A 9‐year chart review study

Author

Bortoletto, Riccardo, primary, Bassani, Lorenzo, additional, Garzitto, Marco, additional, Lamberti, Marco, additional, Simonati, Alessandro, additional, Darra, Francesca, additional, Bhattacharyya, Sagnik, additional, Comacchio, Carla, additional, Balestrieri, Matteo, additional, Arcangeli, Donatella, additional, and Colizzi, Marco, additional

Published
2023
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38. Psychological factors associated with vaccination hesitancy: an observational study of patients hospitalized for COVID-19 in a later phase of the pandemic in Italy

Author

Comacchio, Carla, primary, Cesco, Maddalena, additional, Martinelli, Rosita, additional, Garzitto, Marco, additional, Bianchi, Rita, additional, Innocente, Nicola, additional, Sozio, Emanuela, additional, Tascini, Carlo, additional, Balestrieri, Matteo, additional, and Colizzi, Marco, additional

Published
2023
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40. Association of cannabis with glutamatergic levels in patients with early psychosis: Evidence for altered volume striatal glutamate relationships in patients with a history of cannabis use in early psychosis

Author

Sami, Musa, Worker, Amanda, Colizzi, Marco, Annibale, Luciano, Das, Debasis, Kelbrick, Marlene, Eranti, Savitha, Collier, Tracy, Onyejiaka, Chidimma, O’Neill, Aisling, Lythgoe, David, McGuire, Philip, Williams, Steve C. R., Kempton, Matthew J., and Bhattacharyya, Sagnik

Published
2020
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43. Contributors

Author

Addington, Jean, primary, Al-Diwani, Adam, additional, Albert, Nikolai, additional, Allott, Kelly, additional, Armando, Marco, additional, Barrantes-Vidal, Neus, additional, Bechdolf, A., additional, Bhattacharyya, Sagnik, additional, Burkhardt, E., additional, Cannon, Mary, additional, Chan, Stella W.Y., additional, Chan, Sherry K.W., additional, Chang, W.C., additional, Chen, Eric Y.H., additional, Colizzi, Marco, additional, Corsico, Paolo, additional, Devoe, Daniel J., additional, Donoghue, Brian O., additional, Eliez, Stephan, additional, Flückiger, Rahel, additional, Gifford, George, additional, Glenthøj, Louise Birkedal, additional, Hartmann, Jessica A., additional, Healy, Colm, additional, Hui, Christy L.M., additional, Jones, Hannah J., additional, Jones, Peter B., additional, Kwapil, Thomas R., additional, Lawrie, Stephen M., additional, Lee, Edwin H.M., additional, Leopold, K., additional, Lin, Ashleigh, additional, Macdonald, Alix, additional, McCutcheon, Robert, additional, McGorry, Patrick D., additional, McGuire, Philip, additional, McIntosh, Andrew M., additional, Mei, Cristina, additional, Michel, Chantal, additional, Modinos, Gemma, additional, Morgan, Craig, additional, Nelson, Barnaby, additional, Nordentoft, Merete, additional, Oliver, Dominic, additional, Perez, Jesus, additional, Piskulic, Danijela, additional, Pollak, Thomas A., additional, Racioppi, Anna, additional, Ratheesh, Aswin, additional, Roberts, Tessa, additional, Romaniuk, Liana, additional, Sandini, Corrado, additional, Santesteban-Echarri, Olga, additional, Schneider, Maude, additional, Schultze-Lutter, Frauke, additional, Singh, Ilina, additional, Soneson, Emma, additional, Spooner, Rachael, additional, Stowkowy, Jacqueline, additional, Suen, Y.N., additional, Sussmann, Jessika E., additional, Theodoridou, Anastasia, additional, Thompson, Andrew D., additional, Walters, James T.R., additional, Whalley, Heather C., additional, Yung, Alison R., additional, and Zammit, Stanley, additional

Published
2020
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44. Tic-Related Obsessive–Compulsive and Eating Disorders in Dandy–Walker Variant: A Case Report and Systematic Reappraisal of Psychiatric Profiles.

Author

Bortoletto, Riccardo, Candolo, Anna, Nicotra, Alessandra, Saetti, Luana, Perini, Laura, Balestrieri, Matteo, Colizzi, Marco, and Comacchio, Carla

Subjects
EATING disorders, OBSESSIVE-compulsive disorder, PSYCHOLOGICAL manifestations of general diseases, YOUNG adults, MENTAL health facilities, INFRATENTORIAL brain tumors
Abstract

Dandy–Walker complex (DWC) consists of a continuum of brain malformations involving the posterior fossa, often leading to psychiatric manifestations during adulthood. We discussed the case of a young woman with Dandy–Walker variant (DWV) and a comorbid complex neuropsychiatric presentation, who was diagnosed with an eating disorder, obsessive–compulsive disorder, and a tic disorder. Afterwards, we conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020-compliant systematic review reappraising all evidence of psychiatric outcomes in adults with DWC. Overall, 34 studies were eligible for data extraction, comprising 36 patients. Psychiatric profiles were more common among young adult males, with DWC lesions, especially DWV subtype, being often discovered incidentally after admission to mental health inpatient facilities. Most patients were diagnosed with psychosis and bipolar disorder, often comorbid with cognitive impairment. Psychotropic polypharmacy was frequently prescribed, generally leading to complete recovery. Evidence from our case report and systematic review indicates the importance of monitoring long-term psychiatric sequelae among adult patients with DWC malformations. [ABSTRACT FROM AUTHOR]

Published
2024
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