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8 results on '"Collinet, Marc"'

1. Development and validation of an OECD reproductive toxicity test guideline with the pond snail Lymnaea stagnalis (Mollusca, Gastropoda)

Author

Ducrot, Virginie, Askem, Clare, Azam, Didier, Brettschneider, Denise, Brown, Rebecca, Charles, Sandrine, Coke, Maïra, Collinet, Marc, Delignette-Muller, Marie-Laure, Forfait-Dubuc, Carole, Holbech, Henrik, Hutchinson, Thomas, Jach, Arne, Kinnberg, Karin L., Lacoste, Cédric, Le Page, Gareth, Matthiessen, Peter, Oehlmann, Jörg, Rice, Lynsey, Roberts, Edward, Ruppert, Katharina, Davis, Jessica Elphinstone, Veauvy, Clemence, Weltje, Lennart, Wortham, Ruth, and Lagadic, Laurent

Published
2014
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3. Considerations for test design to accommodate energy-budget models in ecotoxicology: a case study for acetone in the pond snail[i] Lymnaea stagnalis[/i]

Author

Barsi, Alpar, Jager, Tjalling, Collinet, Marc, Lagadic, Laurent, Ducrot, Virginie, Écologie et santé des écosystèmes (ESE), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Department of Theoretical Biology, University of Amsterdam [Amsterdam] (UvA), European Union under the Seventh Framework Program project [PITN-GA-2009-238148], Multiagency Cancer Institute [MODENDO, EST/2011/1/153], Agency for Food, Environmental, and Occupational Health Safety under the Environmental and Occupational Health Plan, European Project: 238148, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)

Subjects
Toxicodynamics, Reproduction, [SDV]Life Sciences [q-bio], Aquatic invertebrates, DEB-kiss, Ecotoxicology, Models, Biological, Toxicokinetics, Acetone, Narcotic, Animals, Toxicity mechanisms, Computer Simulation, Ponds, Mechanistic effect models, Water Pollutants, Chemical, Lymnaea, Ovum
Abstract

Toxicokinetic-toxicodynamic (TKTD) modeling offers many advantages in the analysis of ecotoxicity test data. Calibration of TKTD models, however, places different demands on test design compared with classical concentration-response approaches. In the present study, useful complementary information is provided regarding test design for TKTD modeling. A case study is presented for the pond snail Lymnaea stagnalis exposed to the narcotic compound acetone, in which the data on all endpoints were analyzed together using a relatively simple TKTD model called DEBkiss. Furthermore, the influence of the data used for calibration on accuracy and precision of model parameters is discussed. The DEBkiss model described toxic effects on survival, growth, and reproduction over time well, within a single integrated analysis. Regarding the parameter estimates (e. g., no-effect concentration), precision rather than accuracy was affected depending on which data set was used for model calibration. In addition, the present study shows that the intrinsic sensitivity of snails to acetone stays the same across different life stages, including the embryonic stage. In fact, the data on egg development allowed for selection of a unique metabolic mode of action for the toxicant. Practical and theoretical considerations for test design to accommodate TKTD modeling are discussed in the hope that this information will aid other researchers to make the best possible use of their test animals.

Published
2014

8. Considerations for test design to accommodate energy-budget models in ecotoxicology: a case study for acetone in the pond snail Lymnaea stagnalis.

Author

Barsi A, Jager T, Collinet M, Lagadic L, and Ducrot V

Subjects
Acetone analysis, Animals, Computer Simulation, Ecotoxicology, Lymnaea physiology, Models, Biological, Ovum drug effects, Ovum physiology, Ponds analysis, Reproduction drug effects, Water Pollutants, Chemical analysis, Acetone toxicity, Lymnaea drug effects, Water Pollutants, Chemical toxicity
Abstract

Toxicokinetic-toxicodynamic (TKTD) modeling offers many advantages in the analysis of ecotoxicity test data. Calibration of TKTD models, however, places different demands on test design compared with classical concentration-response approaches. In the present study, useful complementary information is provided regarding test design for TKTD modeling. A case study is presented for the pond snail Lymnaea stagnalis exposed to the narcotic compound acetone, in which the data on all endpoints were analyzed together using a relatively simple TKTD model called DEBkiss. Furthermore, the influence of the data used for calibration on accuracy and precision of model parameters is discussed. The DEBkiss model described toxic effects on survival, growth, and reproduction over time well, within a single integrated analysis. Regarding the parameter estimates (e.g., no-effect concentration), precision rather than accuracy was affected depending on which data set was used for model calibration. In addition, the present study shows that the intrinsic sensitivity of snails to acetone stays the same across different life stages, including the embryonic stage. In fact, the data on egg development allowed for selection of a unique metabolic mode of action for the toxicant. Practical and theoretical considerations for test design to accommodate TKTD modeling are discussed in the hope that this information will aid other researchers to make the best possible use of their test animals., (© 2014 SETAC.)

Published
2014
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